psnGPCR

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Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p_off Int. Strength	s1p_on Int. Strength	s1p_off Hub1?	s1p_on Hub1?	s1p_off Hub2?	s1p_on Hub2?	ConSurf1	ConSurf2
1	2x57	Lig	s1p_off	100	0	Yes	Yes	Yes	Yes	6	0
2	3x28	Lig	s1p_off	100	0	Yes	Yes	Yes	Yes	6	0
3	7x35	Lig	s1p_off	100	0	No	No	Yes	Yes	3	0
4	7x42	Lig	s1p_off	100	0	No	No	Yes	Yes	7	0
5	3x21	NT	s1p_off	100	0	No	No	Yes	Yes	7	6
6	E1x50	NT	s1p_off	100	0	No	No	Yes	Yes	5	6
7	1x46	7x46	s1p_off	100	0	No	No	No	No	7	9
8	1x50	2x47	s1p_off	100	0	Yes	Yes	Yes	No	9	9
9	1x53	7x53	s1p_off	100	0	No	No	Yes	Yes	9	9
10	1x57	I1x50	s1p_off	100	0	No	Yes	Yes	No	7	8
11	1x60	8x53	s1p_off	100	0	Yes	No	No	No	6	7
12	I1x49	I1x50	s1p_off	100	0	No	No	Yes	No	6	8
13	8x50	I1x50	s1p_off	100	0	No	No	Yes	No	8	8
14	2x37	2x38	s1p_off	100	0	No	No	No	Yes	7	7
15	2x39	2x40	s1p_off	100	0	Yes	No	Yes	Yes	8	9
16	2x39	3x50	s1p_off	100	0	Yes	No	No	No	8	9
17	2x39	6x33	s1p_off	100	0	Yes	No	No	No	8	8
18	2x41	4x43	s1p_off	100	0	No	No	No	No	4	2
19	2x43	7x53	s1p_off	100	0	No	No	Yes	Yes	8	9
20	2x46	7x49	s1p_off	100	0	No	No	Yes	No	9	9
21	2x48	4x50	s1p_off	100	0	No	No	Yes	Yes	5	9
22	2x49	3x39	s1p_off	100	0	No	No	No	No	8	9
23	2x50	7x49	s1p_off	100	0	No	No	Yes	No	9	9
24	2x57	2x60	s1p_off	100	0	Yes	Yes	Yes	No	6	5
25	2x60	2x64	s1p_off	100	0	Yes	No	No	No	5	4
26	2x60	3x29	s1p_off	100	0	Yes	No	Yes	Yes	5	5
27	2x63	E1x52	s1p_off	100	0	No	No	No	No	4	5
28	3x28	E1x52	s1p_off	100	0	Yes	Yes	No	No	6	5
29	3x36	5x47	s1p_off	100	0	No	No	Yes	No	6	7
30	3x37	3x41	s1p_off	100	0	Yes	No	No	No	6	5
31	3x37	4x53	s1p_off	100	0	Yes	No	No	No	6	8
32	3x37	4x56	s1p_off	100	0	Yes	No	No	No	6	5
33	3x37	5x47	s1p_off	100	0	Yes	No	Yes	No	6	7
34	3x40	5x47	s1p_off	100	0	No	No	Yes	No	7	7
35	3x40	6x44	s1p_off	100	0	No	No	Yes	No	7	9
36	3x43	6x41	s1p_off	100	0	No	No	No	No	9	7
37	3x43	6x44	s1p_off	100	0	No	No	Yes	No	9	9
38	3x46	6x37	s1p_off	100	0	No	No	No	No	8	8
39	3x49	3x52	s1p_off	100	0	No	Yes	No	No	9	4
40	3x50	6x34	s1p_off	100	0	No	No	Yes	No	9	8
41	5x42	E2	s1p_off	100	0	No	No	Yes	Yes	5	4
42	5x40	E2	s1p_off	100	0	No	No	Yes	Yes	6	4
43	7x32	E2	s1p_off	100	0	No	No	Yes	Yes	1	4
44	6x55	E2	s1p_off	100	0	Yes	No	Yes	Yes	6	4
45	5x41	5x45	s1p_off	100	0	No	No	No	No	5	4
46	5x44	6x56	s1p_off	100	0	No	No	No	No	5	6
47	5x54	6x41	s1p_off	100	0	No	No	No	No	8	7
48	5x58	6x38	s1p_off	100	0	No	Yes	No	No	9	5
49	5x61	6x34	s1p_off	100	0	No	No	Yes	No	9	8
50	6x29	8x49	s1p_off	100	0	No	No	No	No	6	7
51	6x33	8x47	s1p_off	100	0	No	No	Yes	No	8	8
52	6x36	8x47	s1p_off	100	0	No	No	Yes	No	9	8
53	6x39	7x56	s1p_off	100	0	No	No	No	No	6	7
54	6x40	7x49	s1p_off	100	0	No	No	Yes	No	8	9
55	6x48	6x52	s1p_off	100	0	Yes	Yes	No	Yes	8	6
56	6x51	7x38	s1p_off	100	0	No	No	No	No	6	5
57	7x33	7x35	s1p_off	100	0	No	No	No	No	4	3
58	7x35	7x38	s1p_off	100	0	No	No	No	No	3	5
59	7x36	7x37	s1p_off	100	0	No	No	No	No	3	4
60	7x49	7x53	s1p_off	100	0	Yes	No	Yes	Yes	9	9
61	7x53	8x50	s1p_off	100	0	Yes	Yes	No	No	9	8
62	8x47	8x49	s1p_off	100	0	Yes	No	No	No	8	7
63	E1x51	NT	s1p_off	100	0	No	No	Yes	Yes	1	6
64	E1x48	NT	s1p_off	100	0	No	No	Yes	Yes	4	6
65	1x33	1x35	s1p_off	100	0	No	No	No	No	0	5
66	1x49	7x47	s1p_off	100	0	No	No	No	No	8	7
67	1x59	1x60	s1p_off	100	0	No	No	Yes	No	6	6
68	1x60	8x56	s1p_off	100	0	Yes	No	No	No	6	4
69	3x48	4x45	s1p_off	100	0	No	No	No	No	6	6
70	4x54	4x58	s1p_off	100	0	No	No	No	No	4	4
71	5x58	5x62	s1p_off	100	0	No	Yes	Yes	Yes	9	6
72	5x62	6x30	s1p_off	100	0	Yes	Yes	No	No	6	7
73	6x57	6x61	s1p_off	50	0	No	No	No	No	4	4
74	5x44	6x55	s1p_off	50	0	No	No	Yes	No	5	6
75	E1x47	NT	s1p_off	50	0	No	No	Yes	Yes	4	6
76	1x39	2x61	s1p_off	50	0	No	Yes	Yes	No	6	5
77	5x57	5x61	s1p_off	50	0	No	No	No	No	7	9
78	7x51	7x55	s1p_off	0	0	No	No	No	No	6	6
79	2x44	2x47	s1p_off	50	0	No	No	Yes	No	5	9
80	1x51	1x55	s1p_off	50	0	No	No	No	No	4	4
81	1x56	1x60	s1p_off	50	0	No	No	Yes	No	8	6
82	7x54	8x54	s1p_off	50	0	No	No	No	No	7	7
83	2x53	2x57	s1p_off	50	0	No	No	Yes	Yes	8	6
84	7x54	8x51	s1p_off	0	0	No	No	No	No	7	8
85	6x47	7x40	s1p_off	50	0	No	No	No	No	8	7
86	2x52	3x35	s1p_off	50	0	No	No	No	No	6	6
87	3x54	5x65	s1p_off	50	0	No	No	No	No	8	8
88	7x39	7x43	s1p_off	50	0	No	No	No	No	5	6
89	2x41	I1x51	s1p_off	50	0	No	No	No	No	4	7
90	2x54	2x57	s1p_off	50	0	No	No	Yes	Yes	7	6
91	6x54	7x30	s1p_off	0	0	No	No	No	No	4	3
92	5x52	5x56	s1p_off	50	0	No	No	No	No	4	4
93	4x38	4x39	s1p_off	0	0	No	No	No	No	7	1
94	3x50	3x53	s1p_off	50	0	No	No	No	No	9	8
95	6x35	7x56	s1p_off	50	0	No	No	No	No	7	7
96	5x62	5x65	s1p_off	50	0	Yes	Yes	No	No	6	8
97	1x47	2x54	s1p_off	0	0	No	No	No	No	6	7
98	4x58	4x61	s1p_off	50	0	No	No	No	No	4	5
99	6x24	6x27	s1p_off	0	0	No	No	No	No	2	4
100	3x23	NT	s1p_off	0	0	No	No	Yes	Yes	2	6
101	1x43	2x61	s1p_off	0	0	No	No	Yes	No	5	5
102	1x36	NT	s1p_off	50	0	No	No	Yes	Yes	5	6
103	1x33	NT	s1p_off	50	0	No	No	Yes	Yes	0	6
104	1x38	1x42	s1p_off	0	0	No	No	No	No	5	6
105	5x37	6x59	s1p_off	0	0	No	No	No	No	3	4
106	5x45	5x49	s1p_off	0	0	No	No	No	No	4	5
107	1x47	1x51	s1p_off	0	0	No	No	No	No	6	4
108	3x30	E2	s1p_off	0	0	No	No	Yes	Yes	6	4
109	6x31	6x34	s1p_off	0	0	No	No	Yes	No	5	8
110	6x25	6x26	s1p_off	0	0	No	No	No	Yes	4	4
111	3x54	5x68	s1p_off	0	0	No	No	No	No	8	7
112	3x30	3x31	s1p_off	0	0	No	No	No	No	6	4
113	6x45	6x46	s1p_off	0	0	No	No	No	No	6	5
114	2x39	6x32	s1p_off	0	0	Yes	No	No	No	8	7
115	1x37	1x38	s1p_off	0	0	No	No	No	No	5	5
116	6x38	6x42	s1p_off	0	0	No	No	No	No	5	5
117	1x60	I1x48	s1p_off	0	0	Yes	No	No	No	6	6
118	5x63	5x64	s1p_off	0	0	No	No	No	No	3	6
119	4x39	4x40	s1p_off	0	0	No	No	No	No	1	4
120	8x57	8x58	s1p_off	0	0	No	No	No	No	6	0
121	1x48	1x51	s1p_off	0	0	No	No	No	No	4	4
122	6x53	6x57	s1p_off	0	0	No	No	No	No	5	4
123	4x59	4x62	s1p_off	0	0	Yes	No	No	No	5	4
124	4x55	4x59	s1p_off	0	0	No	No	Yes	No	4	5
125	2x37	3x56	s1p_off	0	0	No	No	No	No	7	6
126	Lig	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	6
127	2x60	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
128	3x29	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
129	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
130	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	5	0
131	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
132	7x38	Lig	Shared	100	100	No	No	Yes	Yes	5	0
133	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	6	6
134	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	4	6
135	3x22	NT	Shared	100	100	No	No	Yes	Yes	3	6
136	E1x501	NT	Shared	100	100	No	No	Yes	Yes	5	6
137	3x25	NT	Shared	100	100	Yes	Yes	Yes	Yes	9	6
138	E3	NT	Shared	100	100	Yes	Yes	Yes	Yes	2	6
139	1x40	2x61	Shared	100	100	No	No	Yes	No	3	5
140	1x43	2x58	Shared	100	100	No	No	No	No	5	6
141	1x45	1x49	Shared	100	100	No	No	No	No	4	8
142	1x46	7x47	Shared	100	100	No	No	No	No	7	7
143	1x49	7x50	Shared	100	100	No	No	No	No	8	9
144	1x50	2x50	Shared	100	100	Yes	Yes	No	No	9	9
145	1x50	2x51	Shared	100	100	Yes	Yes	No	No	9	6
146	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
147	1x52	8x54	Shared	100	44.4444	No	No	No	No	7	7
148	1x53	2x47	Shared	100	11.1111	No	No	Yes	No	9	9
149	1x53	7x50	Shared	100	100	No	No	No	No	9	9
150	1x54	2x47	Shared	100	100	No	No	Yes	No	8	9
151	1x57	2x40	Shared	100	100	No	Yes	Yes	Yes	7	9
152	1x60	I1x50	Shared	100	100	Yes	No	Yes	No	6	8
153	2x40	I1x50	Shared	100	100	Yes	Yes	Yes	No	9	8
154	2x38	3x49	Shared	100	100	No	Yes	No	Yes	7	9
155	2x38	4x42	Shared	100	100	No	Yes	No	No	7	7
156	2x42	3x45	Shared	100	47.619	Yes	Yes	No	No	8	7
157	2x42	3x49	Shared	100	100	Yes	Yes	No	Yes	8	9
158	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	7
159	2x45	3x42	Shared	100	100	No	No	No	No	9	8
160	2x45	4x46	Shared	100	100	No	No	No	No	9	7
161	2x45	4x50	Shared	100	100	No	No	Yes	Yes	9	9
162	2x46	3x42	Shared	100	100	No	No	No	No	9	8
163	2x49	4x50	Shared	100	100	No	No	Yes	Yes	8	9
164	2x50	7x46	Shared	100	100	No	No	No	No	9	9
165	2x57	2x61	Shared	100	100	Yes	Yes	Yes	No	6	5
166	2x57	3x32	Shared	100	100	Yes	Yes	No	Yes	6	6
167	2x57	7x42	Shared	100	100	Yes	Yes	No	No	6	7
168	2x60	3x28	Shared	100	100	Yes	No	Yes	Yes	5	6
169	2x63	3x28	Shared	100	100	No	No	Yes	Yes	4	6
170	2x64	3x28	Shared	100	100	No	No	Yes	Yes	4	6
171	E1x49	E1x51	Shared	100	9.52381	No	No	No	No	4	1
172	3x28	E1x50	Shared	100	100	Yes	Yes	No	No	6	5
173	3x24	E1x52	Shared	100	100	No	No	No	No	4	5
174	3x21	3x22	Shared	100	100	No	No	No	No	7	3
175	3x21	3x24	Shared	100	100	No	No	No	No	7	4
176	3x25	3x26	Shared	100	100	Yes	Yes	No	No	9	6
177	3x25	3x28	Shared	100	100	Yes	Yes	Yes	Yes	9	6
178	3x25	3x29	Shared	100	100	Yes	Yes	Yes	Yes	9	5
179	3x25	E2	Shared	100	100	Yes	Yes	Yes	Yes	9	4
180	3x26	4x61	Shared	100	100	No	No	No	No	6	5
181	3x26	E2	Shared	100	100	No	No	Yes	Yes	6	4
182	3x28	3x29	Shared	100	100	Yes	Yes	Yes	Yes	6	5
183	3x29	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	4
184	3x33	E2	Shared	100	100	No	Yes	Yes	Yes	5	4
185	3x33	5x39	Shared	100	100	No	Yes	Yes	Yes	5	7
186	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
187	3x38	4x50	Shared	100	100	No	No	Yes	Yes	7	9
188	3x38	4x53	Shared	100	66.6667	No	No	No	No	7	8
189	3x40	5x50	Shared	100	77.7778	No	No	No	No	7	8
190	3x44	5x54	Shared	100	100	No	Yes	No	No	7	8
191	3x51	5x60	Shared	100	100	No	Yes	No	No	8	5
192	3x51	5x61	Shared	100	44.4444	No	Yes	No	No	8	9
193	4x59	E2	Shared	100	100	Yes	No	Yes	Yes	5	4
194	4x59	5x39	Shared	100	100	Yes	No	Yes	Yes	5	7
195	4x60	E2	Shared	100	100	No	No	Yes	Yes	5	4
196	4x60	5x39	Shared	100	100	No	No	Yes	Yes	5	7
197	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	4
198	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	7	4
199	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
200	6x58	E2	Shared	100	100	No	No	Yes	Yes	4	4
201	7x31	E2	Shared	100	100	No	Yes	Yes	Yes	3	4
202	5x36	5x38	Shared	100	100	No	No	No	No	4	4
203	5x39	5x43	Shared	100	100	Yes	Yes	No	No	7	6
204	5x40	6x55	Shared	100	44.4444	No	No	Yes	No	6	6
205	5x41	6x59	Shared	100	33.3333	No	No	No	No	5	4
206	5x42	5x46	Shared	100	100	No	No	No	No	5	5
207	5x47	6x52	Shared	100	100	Yes	No	No	Yes	7	6
208	5x51	6x44	Shared	100	100	No	No	Yes	No	5	9
209	5x51	6x45	Shared	100	66.6667	No	No	No	No	5	6
210	5x62	5x66	Shared	100	100	Yes	Yes	No	No	6	5
211	6x26	6x29	Shared	100	33.3333	No	Yes	No	No	4	6
212	6x36	7x56	Shared	100	33.3333	No	No	No	No	9	7
213	6x39	7x52	Shared	100	9.52381	No	No	No	No	6	8
214	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
215	6x44	7x45	Shared	100	100	Yes	No	No	Yes	9	9
216	6x47	7x45	Shared	100	100	No	No	No	Yes	8	9
217	6x48	7x41	Shared	100	42.8571	Yes	Yes	No	No	8	7
218	6x48	7x45	Shared	100	100	Yes	Yes	No	Yes	8	9
219	6x50	7x40	Shared	100	100	No	No	No	No	9	7
220	6x51	6x55	Shared	100	100	No	No	Yes	No	6	6
221	6x54	7x37	Shared	100	100	No	No	No	No	4	4
222	6x58	7x31	Shared	100	100	No	No	No	Yes	4	3
223	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	2
224	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
225	7x33	7x36	Shared	100	100	No	No	No	No	4	3
226	8x47	8x50	Shared	100	100	Yes	No	No	No	8	8
227	8x48	8x51	Shared	100	33.3333	No	No	No	No	6	8
228	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	4	0
229	8x49	I1x49	Shared	100	100	No	No	No	No	7	6
230	5x62	6x34	Shared	100	100	Yes	Yes	Yes	No	6	8
231	8x48	8x52	Shared	100	38.0952	No	No	No	No	6	5
232	8x56	8x57	Shared	100	0	No	No	No	No	4	6
233	6x43	7x48	Shared	50	22.2222	No	No	No	No	7	5
234	5x40	6x59	Shared	50	47.619	No	No	No	No	6	4
235	4x38	4x41	Shared	50	100	No	No	No	Yes	7	5
236	3x34	4x54	Shared	50	100	No	No	No	No	5	4
237	6x49	6x50	Shared	50	100	No	No	No	No	6	9
238	2x41	4x42	Shared	50	100	No	No	No	No	4	7
239	1x56	8x54	Shared	50	42.8571	No	No	No	No	8	7
240	2x42	3x46	Shared	50	100	Yes	Yes	No	No	8	8
241	3x41	4x52	Shared	50	33.3333	No	No	No	No	5	4
242	2x56	3x31	Shared	0	11.1111	No	No	No	No	4	4
243	3x47	5x58	Shared	50	100	No	No	No	Yes	8	9
244	7x34	E2	Shared	0	33.3333	No	No	Yes	Yes	4	4
245	2x37	2x40	Shared	0	100	No	No	Yes	Yes	7	9
246	6x43	7x52	Shared	0	100	No	No	No	No	7	8
247	2x52	4x50	Shared	0	11.1111	No	No	Yes	Yes	6	9
248	3x41	4x49	Shared	50	66.6667	No	No	No	No	5	6
249	1x42	1x46	Shared	50	38.0952	No	No	No	No	6	7
250	7x54	7x55	Shared	0	38.0952	No	No	No	No	7	6
251	1x39	7x39	Shared	50	100	No	Yes	No	No	6	5
252	5x48	6x52	Shared	50	47.619	No	No	No	Yes	4	6
253	2x42	4x45	Shared	0	100	Yes	Yes	No	No	8	6
254	3x34	4x57	Shared	0	11.1111	No	No	No	No	5	6
255	5x60	5x64	Shared	50	33.3333	No	No	No	No	5	6
256	1x58	1x59	Shared	0	9.52381	No	No	No	No	3	6
257	4x63	E2	Shared	0	4.7619	No	No	Yes	Yes	5	4
258	1x47	2x55	Shared	0	42.8571	No	No	No	No	6	5
259	1x40	2x62	Shared	0	4.7619	No	No	No	No	3	6
260	4x40	4x44	Shared	0	14.2857	No	No	No	No	4	3
261	3x51	3x55	Shared	0	33.3333	No	Yes	No	No	8	6
262	7x29	E3	Shared	0	0	No	No	Yes	Yes	3	2
263	4x48	4x52	Shared	0	22.2222	No	No	No	No	3	4
264	4x51	4x55	Shared	0	11.1111	No	No	No	No	4	4
265	5x55	6x41	Shared	0	33.3333	No	No	No	No	4	7
266	8x51	8x55	Shared	0	33.3333	No	No	No	No	8	3
267	2x64	Lig	s1p_on	0	100	No	No	Yes	Yes	4	0
268	3x36	Lig	s1p_on	0	100	No	No	Yes	Yes	6	0
269	3x37	Lig	s1p_on	0	100	Yes	No	Yes	Yes	6	0
270	5x47	Lig	s1p_on	0	100	Yes	No	Yes	Yes	7	0
271	6x51	Lig	s1p_on	0	100	No	No	Yes	Yes	6	0
272	6x55	Lig	s1p_on	0	100	Yes	No	Yes	Yes	6	0
273	1x39	2x57	s1p_on	0	100	No	Yes	Yes	Yes	6	6
274	1x43	2x57	s1p_on	0	100	No	No	Yes	Yes	5	6
275	1x46	1x50	s1p_on	0	100	No	No	Yes	Yes	7	9
276	1x47	2x51	s1p_on	0	100	No	No	No	No	6	6
277	1x49	7x51	s1p_on	0	100	No	No	No	No	8	6
278	2x37	2x39	s1p_on	0	100	No	No	Yes	No	7	8
279	2x39	3x49	s1p_on	0	100	Yes	No	No	Yes	8	9
280	2x40	8x49	s1p_on	0	100	Yes	Yes	No	No	9	7
281	2x40	8x50	s1p_on	0	100	Yes	Yes	No	No	9	8
282	2x46	3x43	s1p_on	0	100	No	No	No	No	9	9
283	2x49	3x38	s1p_on	0	100	No	No	No	No	8	7
284	2x57	7x38	s1p_on	0	100	Yes	Yes	No	No	6	5
285	2x60	3x32	s1p_on	0	100	Yes	No	No	Yes	5	6
286	E1x50	E1x501	s1p_on	0	100	No	No	No	No	5	5
287	3x40	6x48	s1p_on	0	100	No	No	Yes	Yes	7	8
288	3x41	5x50	s1p_on	0	100	No	No	No	No	5	8
289	3x43	7x49	s1p_on	0	100	No	No	Yes	No	9	9
290	3x43	7x53	s1p_on	0	100	No	No	Yes	Yes	9	9
291	3x44	5x50	s1p_on	0	100	No	Yes	No	No	7	8
292	3x46	3x50	s1p_on	0	100	No	No	No	No	8	9
293	3x46	7x53	s1p_on	0	100	No	No	Yes	Yes	8	9
294	3x49	3x53	s1p_on	0	100	No	Yes	No	No	9	8
295	3x50	5x58	s1p_on	0	100	No	No	No	Yes	9	9
296	3x50	7x53	s1p_on	0	100	No	No	Yes	Yes	9	9
297	3x51	5x57	s1p_on	0	100	No	Yes	No	No	8	7
298	3x52	4x41	s1p_on	0	100	No	No	No	Yes	4	5
299	3x54	5x61	s1p_on	0	100	No	No	No	No	8	9
300	5x68	I2x50	s1p_on	0	100	No	No	No	No	7	0
301	5x38	E2	s1p_on	0	100	No	No	Yes	Yes	4	4
302	5x37	E2	s1p_on	0	100	No	No	Yes	Yes	3	4
303	5x44	6x52	s1p_on	0	100	No	No	No	Yes	5	6
304	5x47	6x48	s1p_on	0	100	Yes	No	Yes	Yes	7	8
305	5x58	6x37	s1p_on	0	100	No	Yes	No	No	9	8
306	5x58	6x41	s1p_on	0	100	No	Yes	No	No	9	7
307	5x62	6x33	s1p_on	0	100	Yes	Yes	No	No	6	8
308	5x64	5x68	s1p_on	0	100	No	No	No	No	6	7
309	5x65	6x33	s1p_on	0	100	No	No	No	No	8	8
310	6x50	7x37	s1p_on	0	100	No	No	No	No	9	4
311	6x52	6x56	s1p_on	0	100	No	Yes	No	No	6	6
312	7x31	E3	s1p_on	0	100	No	Yes	Yes	Yes	3	2
313	7x45	7x49	s1p_on	0	100	No	Yes	Yes	No	9	9
314	7x52	7x53	s1p_on	0	100	No	No	Yes	Yes	8	9
315	7x54	8x50	s1p_on	0	100	No	No	No	No	7	8
316	3x40	Lig	s1p_on	0	100	No	No	Yes	Yes	7	0
317	3x56	I2x51	s1p_on	0	100	No	No	No	No	6	0
318	7x35	7x36	s1p_on	0	100	No	No	No	No	3	3
319	5x43	Lig	s1p_on	0	100	No	No	Yes	Yes	6	0
320	1x59	8x57	s1p_on	0	100	No	No	No	No	6	6
321	2x38	4x38	s1p_on	0	100	No	Yes	No	No	7	7
322	2x38	4x41	s1p_on	0	100	No	Yes	No	Yes	7	5
323	3x56	I2x54	s1p_on	0	100	No	No	No	No	6	0
324	1x51	2x51	s1p_on	0	47.619	No	No	No	No	4	6
325	7x42	7x46	s1p_on	0	42.8571	No	No	No	No	7	9
326	5x66	6x30	s1p_on	0	47.619	No	No	No	No	5	7
327	3x44	3x48	s1p_on	0	44.4444	No	Yes	No	No	7	6
328	6x34	6x38	s1p_on	0	69.8413	Yes	No	No	No	8	5
329	3x53	3x56	s1p_on	0	33.3333	No	No	No	No	8	6
330	2x39	7x56	s1p_on	0	33.3333	Yes	No	No	No	8	7
331	4x56	5x39	s1p_on	0	38.0952	No	No	Yes	Yes	5	7
332	5x69	6x26	s1p_on	0	33.3333	No	No	No	Yes	0	4
333	1x36	2x61	s1p_on	0	44.4444	No	No	Yes	No	5	5
334	3x48	5x57	s1p_on	0	47.619	No	No	No	No	6	7
335	4x39	4x43	s1p_on	0	25.3968	No	No	No	No	1	2
336	2x50	3x39	s1p_on	0	66.6667	No	No	No	No	9	9
337	I2x52	I2x53	s1p_on	0	38.0952	No	No	No	No	0	0
338	3x44	5x53	s1p_on	0	52.381	No	Yes	No	No	7	6
339	3x21	3x23	s1p_on	0	38.0952	No	No	No	No	7	2
340	5x66	5x70	s1p_on	0	44.4444	No	No	No	No	5	0
341	1x35	7x33	s1p_on	0	33.3333	No	No	No	No	5	4
342	1x57	2x44	s1p_on	0	44.4444	No	Yes	No	No	7	5
343	5x58	6x40	s1p_on	0	42.8571	No	Yes	No	No	9	8
344	7x32	NT	s1p_on	0	25.3968	No	No	Yes	Yes	1	6
345	6x54	7x31	s1p_on	0	66.6667	No	No	No	Yes	4	3
346	I1x49	I1x51	s1p_on	0	33.3333	No	No	No	No	6	7
347	1x57	2x43	s1p_on	0	38.0952	No	Yes	No	No	7	8
348	1x39	7x35	s1p_on	0	38.0952	No	Yes	No	No	6	3
349	1x54	2x48	s1p_on	0	66.6667	No	No	No	No	8	5
350	6x23	6x26	s1p_on	0	33.3333	No	No	No	Yes	0	4
351	6x33	6x37	s1p_on	0	49.2063	No	No	No	No	8	8
352	6x57	E3	s1p_on	0	38.0952	No	No	Yes	Yes	4	2
353	2x53	2x54	s1p_on	0	0	No	No	No	No	8	7
354	I2x51	I2x52	s1p_on	0	33.3333	No	No	No	No	0	0
355	2x53	3x35	s1p_on	0	0	No	No	No	No	8	6
356	3x34	4x53	s1p_on	0	47.619	No	No	No	No	5	8
357	4x56	5x42	s1p_on	0	0	No	No	No	No	5	5
358	6x53	6x56	s1p_on	0	53.9683	No	No	No	No	5	6
359	4x61	4x62	s1p_on	0	20.6349	No	No	No	No	5	4
360	1x38	1x39	s1p_on	0	33.3333	No	No	No	Yes	5	6
361	I1x48	I1x51	s1p_on	0	33.3333	No	No	No	No	6	7
362	6x27	6x28	s1p_on	0	38.0952	No	No	No	Yes	4	5
363	1x33	1x37	s1p_on	0	33.3333	No	No	No	No	0	5
364	2x56	3x32	s1p_on	0	33.3333	No	No	No	Yes	4	6
365	2x53	3x36	s1p_on	0	0	No	No	No	No	8	6
366	5x62	5x63	s1p_on	0	33.3333	Yes	Yes	No	No	6	3
367	1x48	1x52	s1p_on	0	14.2857	No	No	No	No	4	7
368	E1x47	E1x48	s1p_on	0	33.3333	No	No	No	No	4	4
369	4x41	I2x56	s1p_on	0	4.7619	No	Yes	No	No	5	0
370	2x41	4x39	s1p_on	0	33.3333	No	No	No	No	4	1
371	6x47	7x43	s1p_on	0	33.3333	No	No	No	No	8	6
372	1x55	1x59	s1p_on	0	33.3333	No	No	No	No	4	6
373	6x26	I3	s1p_on	0	33.3333	No	Yes	No	No	4	0
374	1x57	1x58	s1p_on	0	33.3333	No	Yes	No	No	7	3
375	3x30	3x33	s1p_on	0	0	No	No	No	Yes	6	5
376	2x64	E1x47	s1p_on	0	20.6349	No	No	No	No	4	4
377	5x48	5x49	s1p_on	0	0	No	No	No	No	4	5
378	7x55	8x54	s1p_on	0	33.3333	No	No	No	No	6	7
379	5x73	I3	s1p_on	0	14.2857	No	No	No	No	0	0
380	8x53	I1x50	s1p_on	0	14.2857	No	No	Yes	No	7	8
381	1x33	1x34	s1p_on	0	33.3333	No	No	No	No	0	4
382	6x57	7x30	s1p_on	0	0	No	No	No	No	4	3
383	E1x48	E1x49	s1p_on	0	0	No	No	No	No	4	4
384	5x71	5x72	s1p_on	0	9.52381	No	No	No	No	0	0
385	7x55	8x51	s1p_on	0	11.1111	No	No	No	No	6	8
386	4x38	4x40	s1p_on	0	9.52381	No	No	No	No	7	4
387	6x31	6x35	s1p_on	0	11.1111	No	No	No	No	5	7
388	6x25	6x28	s1p_on	0	11.1111	No	No	No	Yes	4	5
389	1x32	1x35	s1p_on	0	22.2222	No	No	No	No	0	5
390	6x28	6x29	s1p_on	0	11.1111	No	Yes	No	No	5	6
391	4x57	4x58	s1p_on	0	0	No	No	No	No	6	4
392	5x72	5x74	s1p_on	0	9.52381	No	No	No	No	0	0
393	1x32	1x34	s1p_on	0	22.2222	No	No	No	No	0	4
394	5x49	5x52	s1p_on	0	0	No	No	No	No	5	4
395	5x56	5x60	s1p_on	0	11.1111	No	No	No	No	4	5
396	4x46	4x47	s1p_on	0	0	No	No	No	No	7	4
397	2x59	2x63	s1p_on	0	11.1111	No	No	No	No	7	4
398	5x55	5x59	s1p_on	0	0	No	No	No	No	4	3
399	4x51	4x54	s1p_on	0	0	No	No	No	No	4	4
400	6x24	6x25	s1p_on	0	11.1111	No	No	No	No	2	4
401	I2x54	I2x55	s1p_on	0	4.7619	No	No	No	No	0	0
402	5x68	5x71	s1p_on	0	9.52381	No	No	No	No	7	0
403	5x67	5x71	s1p_on	0	4.7619	No	No	No	No	5	0
404	6x28	6x30	s1p_on	0	9.52381	No	Yes	No	No	5	7
405	6x59	6x60	s1p_on	0	9.52381	No	No	No	No	4	4
406	1x40	1x44	s1p_on	0	0	No	No	No	No	3	5
407	5x45	5x48	s1p_on	0	0	No	No	No	No	4	4
408	3x27	4x61	s1p_on	0	0	No	No	No	No	4	5
409	6x35	6x36	s1p_on	0	0	No	No	No	No	7	9
410	1x37	1x41	s1p_on	0	0	No	No	No	No	5	4
411	6x42	6x43	s1p_on	0	0	No	No	No	No	5	7
412	6x32	6x35	s1p_on	0	0	No	No	No	No	7	7

Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	s1p_off Avg Int. Strength	s1p_on Avg Int. Strength	s1p_off Num Of Links	s1p_on Num Of Links	ConSurf
1	1x60	s1p_off	50	0	6	1	6
2	I1x50	s1p_off	100	0	5	3	8
3	2x39	s1p_off	100	11.1111	4	3	8
4	2x47	s1p_off	50	0	4	2	9
5	2x60	s1p_off	100	11.1111	5	3	5
6	2x61	s1p_off	0	0	4	3	5
7	3x37	s1p_off	0	0	4	1	6
8	4x59	s1p_off	0	0	4	2	5
9	5x47	s1p_off	100	0	4	3	7
10	6x34	s1p_off	50	0	4	2	8
11	6x44	s1p_off	100	14.2857	5	3	9
12	6x55	s1p_off	0	0	4	3	6
13	7x49	s1p_off	50	33.3333	4	2	9
14	8x47	s1p_off	50	0	4	1	8
15	Lig	Shared	100	100	12	16	0
16	NT	Shared	100	100	16	9	6
17	1x50	Shared	50	55.5556	4	4	9
18	2x40	Shared	100	39.6825	4	5	9
19	2x42	Shared	0	33.3333	5	5	8
20	2x57	Shared	100	55.5556	7	6	6
21	3x25	Shared	100	95.2381	5	5	9
22	3x28	Shared	100	90.4762	8	6	6
23	3x29	Shared	100	41.2698	5	4	5
24	4x50	Shared	0	22.2222	5	4	9
25	E2	Shared	100	100	21	18	4
26	5x39	Shared	100	100	5	6	7
27	5x62	Shared	50	22.2222	5	4	6
28	6x48	Shared	100	66.6667	6	7	8
29	E3	Shared	100	88.8889	5	7	2
30	7x53	Shared	100	55.5556	4	4	9
31	1x39	s1p_on	0	0	2	4	6
32	1x57	s1p_on	0	0	2	4	7
33	2x38	s1p_on	0	0	3	4	7
34	3x32	s1p_on	0	0	2	4	6
35	3x33	s1p_on	0	4.7619	3	4	5
36	3x44	s1p_on	0	0	1	4	7
37	3x49	s1p_on	0	42.8571	3	4	9
38	3x51	s1p_on	0	14.2857	3	4	8
39	4x41	s1p_on	0	0	1	4	5
40	5x58	s1p_on	50	55.5556	3	5	9
41	6x28	s1p_on	0	0	0	4	5
42	6x52	s1p_on	50	55.5556	3	4	6
43	7x31	s1p_on	50	47.619	2	4	3
44	7x45	s1p_on	0	47.619	3	4	9
45	6x26	s1p_on	0	22.2222	2	4	4

Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p_off Recurrence	s1p_on Recurrence	s1p_off Hub1?	s1p_on Hub1?	s1p_off Hub2?	s1p_on Hub2?	ConSurf1	ConSurf2
1	2x57	Lig	s1p_off	19.7369	0	Yes	Yes	Yes	Yes	6	0
2	2x50	7x49	s1p_off	14.3185	0	No	No	Yes	No	9	9
3	2x46	7x49	s1p_off	94.3178	0	No	No	Yes	No	9	9
4	3x38	4x53	s1p_off	98.0662	9.74223	No	No	No	No	7	8
5	3x37	4x53	s1p_off	98.3613	0	Yes	No	No	No	6	8
6	3x37	5x47	s1p_off	100	0	Yes	No	Yes	No	6	7
7	3x36	5x47	s1p_off	46.0507	0	No	No	Yes	No	6	7
8	3x36	6x48	s1p_off	45.9346	2.76272	No	No	Yes	Yes	6	8
9	7x49	7x53	s1p_off	84.4384	0	Yes	No	Yes	Yes	9	9
10	6x48	6x52	s1p_off	46.5624	0	Yes	Yes	No	Yes	8	6
11	1x56	1x60	s1p_off	10.702	0	No	No	Yes	No	8	6
12	1x60	I1x50	s1p_off	18.5565	1.06191	Yes	No	Yes	No	6	8
13	8x50	I1x50	s1p_off	54.282	0	No	No	Yes	No	8	8
14	7x53	8x50	s1p_off	82.0619	0	Yes	Yes	No	No	9	8
15	2x40	I1x50	s1p_off	39.0971	3.18572	Yes	Yes	Yes	No	9	8
16	2x37	2x38	s1p_off	18.8987	0	No	No	No	Yes	7	7
17	2x38	4x42	s1p_off	10.0333	8.79489	No	Yes	No	No	7	7
18	2x39	2x40	s1p_off	21.6676	0	Yes	No	Yes	Yes	8	9
19	2x39	6x33	s1p_off	19.7118	0	Yes	No	No	No	8	8
20	6x33	8x47	s1p_off	20.2832	0	No	No	Yes	No	8	8
21	8x47	8x50	s1p_off	29.4217	1.269	Yes	No	No	No	8	8
22	2x39	3x50	s1p_off	36.9216	0	Yes	No	No	No	8	9
23	3x50	6x34	s1p_off	33.6849	0	No	No	Yes	No	9	8
24	5x61	6x34	s1p_off	13.0847	0	No	No	Yes	No	9	8
25	5x62	6x34	s1p_off	17.5425	2.8156	Yes	Yes	Yes	No	6	8
26	2x57	2x61	Shared	10.3692	10.9011	Yes	Yes	Yes	No	6	5
27	2x46	3x42	Shared	94.682	20.3525	No	No	No	No	9	8
28	2x45	3x42	Shared	95.0399	19.0571	No	No	No	No	9	8
29	2x45	4x50	Shared	95.8247	15.1179	No	No	Yes	Yes	9	9
30	3x38	4x50	Shared	97.7648	11.0641	No	No	Yes	Yes	7	9
31	6x48	Lig	Shared	91.3135	83.1152	Yes	Yes	Yes	Yes	8	0
32	5x47	6x52	Shared	46.7948	12.0864	Yes	No	No	Yes	7	6
33	2x37	2x40	Shared	20.6724	31.4959	No	No	Yes	Yes	7	9
34	Lig	NT	Shared	19.3382	15.5849	Yes	Yes	Yes	Yes	0	6
35	E2	Lig	Shared	37.8226	25.4285	Yes	Yes	Yes	Yes	4	0
36	1x39	2x57	s1p_on	0	23.503	No	Yes	Yes	Yes	6	6
37	2x57	3x32	s1p_on	0.0565078	39.9692	Yes	Yes	No	Yes	6	6
38	3x32	Lig	s1p_on	1.24317	41.3792	No	Yes	Yes	Yes	6	0
39	2x57	7x38	s1p_on	0	38.8279	Yes	Yes	No	No	6	5
40	7x38	Lig	s1p_on	2.40786	39.7048	No	No	Yes	Yes	5	0
41	1x50	7x50	s1p_on	3.07968	17.3386	Yes	Yes	No	No	9	9
42	1x50	2x50	s1p_on	7.00383	34.1176	Yes	Yes	No	No	9	9
43	2x50	7x46	s1p_on	6.42619	38.2243	No	No	No	No	9	9
44	7x42	7x46	s1p_on	0	40.2644	No	No	No	No	7	9
45	2x57	7x42	s1p_on	0.0565078	42.2957	Yes	Yes	No	No	6	7
46	1x57	2x40	s1p_on	0.113016	10.0022	No	Yes	Yes	Yes	7	9
47	2x37	2x39	s1p_on	0	32.6548	No	No	Yes	No	7	8
48	2x39	3x49	s1p_on	0	39.2465	Yes	No	No	Yes	8	9
49	2x42	3x49	s1p_on	5.99611	53.4435	Yes	Yes	No	Yes	8	9
50	2x42	3x46	s1p_on	3.87706	67.7462	Yes	Yes	No	No	8	8
51	3x46	7x53	s1p_on	0	62.1414	No	No	Yes	Yes	8	9
52	3x43	7x53	s1p_on	0	91.2844	No	No	Yes	Yes	9	9
53	3x43	7x49	s1p_on	0	99.5946	No	No	Yes	No	9	9
54	7x45	7x49	s1p_on	0	100	No	Yes	Yes	No	9	9
55	6x48	7x45	s1p_on	6.24411	99.5902	Yes	Yes	No	Yes	8	9
56	2x42	4x42	s1p_on	6.07773	13.2893	Yes	Yes	No	No	8	7
57	2x40	8x50	s1p_on	0	13.677	Yes	Yes	No	No	9	8
58	2x46	3x43	s1p_on	0	21.6391	No	No	No	No	9	9
59	3x40	5x50	s1p_on	0.828781	30.8482	No	No	No	No	7	8
60	3x40	Lig	s1p_on	0	18.0392	No	No	Yes	Yes	7	0
61	3x44	5x50	s1p_on	0	24.349	No	Yes	No	No	7	8
62	3x50	7x53	s1p_on	0	25.3712	No	No	Yes	Yes	9	9
63	3x50	5x58	s1p_on	0	30.7425	No	No	No	Yes	9	9
64	3x51	5x57	s1p_on	0	17.6294	No	Yes	No	No	8	7
65	3x48	5x57	s1p_on	0	18.991	No	No	No	No	6	7
66	3x44	3x48	s1p_on	0	20.3437	No	Yes	No	No	7	6
67	3x51	5x60	s1p_on	5.81717	12.0775	No	Yes	No	No	8	5
68	4x56	5x39	s1p_on	0	10.4516	No	No	Yes	Yes	5	7
69	5x58	6x37	s1p_on	0	24.1022	No	Yes	No	No	9	8
70	5x62	6x33	s1p_on	0	21.15	Yes	Yes	No	No	6	8
71	6x33	6x37	s1p_on	0	23.1196	No	No	No	No	8	8
72	5x62	5x66	s1p_on	1.94324	15.9991	Yes	Yes	No	No	6	5
73	7x33	7x36	s1p_on	5.18302	13.1571	No	No	No	No	4	3
74	7x35	7x36	s1p_on	0	15.3117	No	No	No	No	3	3
75	1x39	7x35	s1p_on	0	17.1712	No	Yes	No	No	6	3
76	7x54	8x50	s1p_on	0	11.443	No	No	No	No	7	8
77	5x66	6x30	s1p_on	0	13.3333	No	No	No	No	5	7
78	6x28	6x30	s1p_on	0	12.0115	No	Yes	No	No	5	7
79	7x54	7x55	s1p_on	2.18811	10.249	No	No	No	No	7	6
80	1x35	7x33	s1p_on	0	11.518	No	No	No	No	5	4
81	3x40	6x48	s1p_on	0	14.078	No	No	Yes	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
Lig	NT	Shared	12.72	6.77889	1	1	0	1
2x57	Lig	s1p_off	6.34	0	1	0	1	0
2x60	Lig	Shared	10.385	9.00381	1	1	1	0
3x28	Lig	s1p_off	3.94	0	1	1	1	0
3x29	Lig	Shared	14.285	7.77905	1	1	1	0
3x32	Lig	Shared	11.445	3.51048	1	1	1	0
3x33	Lig	Shared	7.885	11.7603	1	1	1	0
6x48	Lig	Shared	3.43	3.01302	1	1	1	0
7x35	Lig	s1p_off	6.135	0	1	0	1	0
7x38	Lig	Shared	18.94	6.56619	1	0	1	0
7x42	Lig	s1p_off	4.115	0	1	0	1	0
NT	NT	Shared	59.835	30.6487	1	1	1	1
E2	NT	Shared	83.29	69.3789	1	1	1	1
3x21	NT	s1p_off	6.125	0	1	0	2	1
3x22	NT	Shared	9.495	6.5046	1	1	2	1
E1x50	NT	s1p_off	5.755	0	1	0	2	1
E1x501	NT	Shared	19.445	15.7022	0	1	2	1
3x25	NT	Shared	11.72	4.05571	1	1	2	1
E3	NT	Shared	12.115	6.43032	1	1	2	1
2x57	2x60	s1p_off	4.65	0	1	0	1	1
2x57	2x61	Shared	5.275	7.40206	1	0	1	2
2x57	3x32	Shared	4.89	4.33238	1	0	1	1
2x57	7x42	Shared	13.055	4.98651	1	0	1	1
2x60	2x64	s1p_off	5.215	0	1	1	1	1
2x60	3x28	Shared	6.63	6.85143	1	1	1	1
2x60	3x29	s1p_off	7.89	0	1	1	1	1
2x63	E1x52	s1p_off	4.15	0	1	0	2	2
2x63	3x28	Shared	3.64	7.01619	1	0	2	1
2x64	3x28	Shared	6.585	2.92905	1	0	1	1
3x28	E1x50	Shared	9.7	4.41397	1	1	1	2
3x28	E1x52	s1p_off	5.465	0	1	1	1	2
3x21	3x22	Shared	3.53	3.95619	1	0	2	2
3x25	3x26	Shared	6.515	4.02556	1	1	2	2
3x25	3x28	Shared	9	7.61905	1	1	2	1
3x25	3x29	Shared	7.63	10.7657	1	1	2	1
3x25	E2	Shared	28.31	17.7967	1	1	2	1
3x26	E2	Shared	24.83	15.9027	1	1	2	1
3x28	3x29	Shared	12.79	3.12079	1	1	1	1
3x29	E2	Shared	6.02	12.7822	1	1	1	1
3x33	E2	Shared	14.905	3.57317	1	1	1	1
3x33	5x39	Shared	5.675	7.76016	1	1	1	2
3x36	5x47	s1p_off	7.31	0	0	1	1	1
3x36	6x48	Shared	16.51	5.09651	0	1	1	1
3x37	3x41	s1p_off	4.115	0	0	0	1	2
3x37	4x53	s1p_off	6.46	0	0	0	1	2
3x37	4x56	s1p_off	5.185	0	0	0	1	2
3x37	5x47	s1p_off	5.885	0	0	0	1	1
3x40	5x47	s1p_off	6.55	0	0	1	1	1
3x40	5x50	Shared	3.795	2.83413	0	1	1	2
3x40	6x44	s1p_off	3.275	0	0	1	1	2
4x59	E2	Shared	4.56	4.12095	1	1	2	1
4x59	5x39	Shared	4.1	5.04095	1	1	2	2
4x60	E2	Shared	11.825	8.92984	1	1	2	1
4x60	5x39	Shared	12.52	14.1086	1	1	2	2
5x36	E2	Shared	9.995	6.60603	1	1	2	1
5x39	E2	Shared	20.425	9.91556	1	1	2	1
5x42	E2	s1p_off	6.015	0	1	0	2	1
E2	E2	Shared	51.02	42.0203	1	1	1	1
5x40	E2	s1p_off	8.49	0	1	0	2	1
6x58	E2	Shared	21.885	12.6692	1	1	2	1
7x31	E2	Shared	8.105	6.69333	1	1	2	1
7x32	E2	s1p_off	3.33	0	0	0	2	1
6x55	E2	s1p_off	3.67	0	1	1	1	1
5x36	5x38	Shared	5.97	6.30429	1	1	2	2
5x39	5x43	Shared	9.41	4.35222	1	1	2	1
5x40	6x55	Shared	5.835	2.62111	1	0	2	1
5x47	6x52	Shared	6.965	14.5119	0	1	1	2
6x44	6x48	Shared	13.53	6.90571	1	1	2	1
6x44	7x45	Shared	7.25	5.44651	1	1	2	2
6x48	6x52	s1p_off	10.525	0	1	1	1	2
6x48	7x41	Shared	9.075	1.85238	1	1	1	2
6x48	7x45	Shared	6.215	12.6452	1	1	1	2
6x51	6x55	Shared	3.46	5.14302	0	1	1	1
6x51	7x38	s1p_off	3.46	0	0	1	1	1
6x58	7x31	Shared	9.5	6.93571	1	1	2	2
E3	E3	Shared	13.87	3.84429	1	1	2	2
7x33	7x35	s1p_off	5.235	0	0	0	2	1
7x33	7x36	Shared	3.6	5.3019	0	0	2	2
7x35	7x38	s1p_off	5.33	0	1	0	1	1
E2	Lig	Shared	3.31	3.73825	1	1	1	0
E1x51	NT	s1p_off	3.795	0	1	0	2	1
E1x48	NT	s1p_off	5.565	0	0	0	2	1
5x44	6x55	s1p_off	2.965	0	0	0	2	1
E1x47	NT	s1p_off	2.895	0	0	0	2	1
1x39	2x61	s1p_off	2.855	0	0	0	2	2
2x53	2x57	s1p_off	2.67	0	0	0	2	1
7x34	E2	Shared	2.545	1.64889	0	0	2	1
2x54	2x57	s1p_off	2.175	0	0	0	2	1
4x63	E2	Shared	1.7	1.3746	0	0	2	1
3x23	NT	s1p_off	1.695	0	0	0	2	1
1x43	2x61	s1p_off	1.615	0	0	0	2	2
1x36	NT	s1p_off	1.575	0	0	0	2	1
1x33	NT	s1p_off	1.545	0	1	0	2	1
3x30	E2	s1p_off	1.45	0	1	0	2	1
2x64	Lig	s1p_on	0	4.22397	1	0	1	0
3x36	Lig	s1p_on	0	8.78873	0	1	1	0
3x37	Lig	s1p_on	0	6.00143	0	0	1	0
5x47	Lig	s1p_on	0	4.97524	0	1	1	0
6x51	Lig	s1p_on	0	4.99206	0	1	1	0
6x55	Lig	s1p_on	0	4.04492	1	1	1	0
1x39	2x57	s1p_on	0	4.27444	0	0	2	1
1x43	2x57	s1p_on	0	3.04968	0	0	2	1
2x57	7x38	s1p_on	0	7.85175	1	0	1	1
2x60	3x32	s1p_on	0	3.62825	1	1	1	1
E1x50	E1x501	s1p_on	0	3.5981	1	0	2	2
3x40	6x48	s1p_on	0	3.77571	0	1	1	1
3x41	5x50	s1p_on	0	4.07635	0	0	2	2
5x38	E2	s1p_on	0	6.85032	0	1	2	1
5x37	E2	s1p_on	0	4.62016	0	0	2	1
5x44	6x52	s1p_on	0	3.94079	0	0	2	2
5x47	6x48	s1p_on	0	6.48921	0	1	1	1
7x31	E3	s1p_on	0	4.38698	1	1	2	2
3x40	Lig	s1p_on	0	3.71016	0	1	1	0
7x35	7x36	s1p_on	0	3.91587	1	0	1	2
5x43	Lig	s1p_on	0	5.14159	0	0	1	0
7x42	7x46	s1p_on	0	2.86429	1	0	1	2
4x56	5x39	s1p_on	0	2.49175	0	0	2	2
1x36	2x61	s1p_on	0	2.45016	0	0	2	2
3x21	3x23	s1p_on	0	2.27667	1	0	2	2
7x32	NT	s1p_on	0	2.05619	0	0	2	1
1x39	7x35	s1p_on	0	1.98635	0	0	2	1
2x53	2x54	s1p_on	0	1.85714	0	0	2	2
4x56	5x42	s1p_on	0	1.70365	0	0	2	2
2x56	3x32	s1p_on	0	1.46222	0	0	2	1
2x53	3x36	s1p_on	0	1.42952	0	0	2	1
E1x47	E1x48	s1p_on	0	1.35333	0	0	2	2
3x30	3x33	s1p_on	0	1.12651	1	0	2	1
2x64	E1x47	s1p_on	0	1.11984	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	s1p_off	s1p1_off s1p5_off
	s1p_on	s1p1_on s1p3_on s1p5_on

Network Difference
Value	s1p_off	s1p_on
I_min	3.255	2.89603
Number of Linked Nodes	232	257
Number of Specific Nodes	2 (0.86%)	27 (10.51%)
Number of Shared Nodes	230 (99.14%)	230 (89.49%)
Number of Links	266	287
Number of Specific Links	125 (46.99%)	146 (50.87%)
Number of Shared Links	141 (53.01%)	141 (49.13%)
Number of Hubs	30	31
Number of Specific Hubs	14 (46.67%)	15 (48.39%)
Number of Shared Hubs	16 (53.33%)	16 (51.61%)
Average % Shared Neighbours (Jaccard)	34.22
Average % Shared Neighbours (Otsuka)	42.79
Average % Shared Neighbours (Overlap Coefficient)	50.48
Average % Shared Cliques (k3-6)	58.82
Graphlets Similarity	0.59283

Paths Difference
Value	s1p_off	s1p_on
Number Of Nodes in MetaPath	34	57
Specific Nodes in MetaPath	10 (29.41%)	33 (57.89%)
Shared Nodes in MetaPath	230 (99.14%)	230 (99.14%)
Number Of Links MetaPath	35	56
Specific Links in MetaPath	25 (71.43%)	46 (82.14%)
Shared Links in MetaPath	141 (53.01%)	141 (53.01%)
Number of Shortest Paths	46776	45178
Length Of Smallest Path	3	3
Average Path Length	16.3156	13.1356
Length of Longest Path	31	30
Minimum Path Strength	0.6975	0.291667
Average Path Strength	6.36826	4.88937
Maximum Path Strength	51.8575	39.6472
Minimum Path Correlation	0.7	0.700476
Average Path Correlation	0.904912	0.91632
Maximum Path Correlation	0.99	0.99127
Minimum % Of Corr. Nodes	4	3.7037
Average % Of Corr. Nodes	41.8598	46.6484
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.9458	40.942
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p_off_on.zip<

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