psnGPCR

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Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p_off Int. Strength	s1p_on Int. Strength	s1p_off Hub1?	s1p_on Hub1?	s1p_off Hub2?	s1p_on Hub2?	ConSurf1	ConSurf2
1	3x21	NT	s1p_off	11	0	No	No	Yes	Yes	7	6
2	E1x50	NT	s1p_off	4.99	0	No	No	Yes	Yes	5	6
3	1x31	NT	s1p_off	6.12	0	No	No	Yes	Yes	2	6
4	1x39	1x42	s1p_off	3.77	0	Yes	Yes	No	No	6	6
5	1x48	1x52	s1p_off	4.87	0	No	No	No	No	4	7
6	1x49	7x47	s1p_off	4.91	0	Yes	No	No	No	8	7
7	1x53	7x53	s1p_off	5.05	0	No	No	Yes	Yes	9	9
8	6x29	I1x49	s1p_off	5.4	0	Yes	No	No	No	6	6
9	8x50	I1x50	s1p_off	3.73	0	No	No	Yes	Yes	8	8
10	2x41	I1x51	s1p_off	5.44	0	No	No	No	No	4	7
11	2x37	2x38	s1p_off	4.32	0	No	No	No	No	7	7
12	2x39	2x43	s1p_off	5.83	0	Yes	No	No	No	8	8
13	2x39	3x50	s1p_off	11.17	0	Yes	No	Yes	No	8	9
14	2x39	6x33	s1p_off	4.24	0	Yes	No	No	No	8	8
15	2x43	7x53	s1p_off	4.84	0	No	No	Yes	Yes	8	9
16	2x45	3x42	s1p_off	7.45	0	Yes	No	No	No	9	8
17	2x48	4x50	s1p_off	5.69	0	No	No	Yes	Yes	5	9
18	2x49	3x39	s1p_off	4.89	0	No	No	No	No	8	9
19	2x57	2x60	s1p_off	6.98	0	Yes	Yes	Yes	No	6	5
20	2x60	3x29	s1p_off	6.57	0	Yes	No	Yes	Yes	5	5
21	2x63	E1x52	s1p_off	6.92	0	No	No	No	No	4	5
22	3x28	E1x52	s1p_off	4.86	0	Yes	Yes	No	No	6	5
23	3x28	Lig	s1p_off	5.8	0	Yes	Yes	Yes	Yes	6	0
24	3x32	Lig	s1p_off	14.45	0	No	No	Yes	Yes	6	0
25	3x36	5x47	s1p_off	4.87	0	No	No	Yes	No	6	7
26	3x37	5x47	s1p_off	5.28	0	No	No	Yes	No	6	7
27	3x40	5x47	s1p_off	7.87	0	No	No	Yes	No	7	7
28	3x43	6x44	s1p_off	8.53	0	No	No	Yes	No	9	9
29	3x46	6x37	s1p_off	4.61	0	No	No	No	No	8	8
30	3x49	3x50	s1p_off	13.96	0	Yes	Yes	Yes	No	9	9
31	3x50	3x53	s1p_off	7.76	0	Yes	No	No	No	9	8
32	3x50	6x34	s1p_off	8.5	0	Yes	No	No	No	9	8
33	4x59	4x60	s1p_off	4.93	0	No	No	No	No	5	5
34	5x42	E2	s1p_off	8.02	0	No	No	Yes	Yes	5	4
35	5x40	E2	s1p_off	7.16	0	No	No	Yes	Yes	6	4
36	5x52	5x56	s1p_off	4.28	0	No	No	No	No	4	4
37	5x54	6x41	s1p_off	8.56	0	No	No	No	No	8	7
38	5x57	5x61	s1p_off	5.71	0	No	No	No	No	7	9
39	5x58	6x38	s1p_off	4.84	0	No	Yes	Yes	No	9	5
40	5x60	5x63	s1p_off	10.54	0	No	No	No	No	5	3
41	5x60	5x64	s1p_off	10.93	0	No	No	No	No	5	6
42	6x29	8x49	s1p_off	12.69	0	Yes	No	No	No	6	7
43	6x33	8x47	s1p_off	6.87	0	No	No	No	No	8	8
44	6x33	8x49	s1p_off	5.3	0	No	No	No	No	8	7
45	6x35	6x39	s1p_off	7.27	0	No	No	No	No	7	6
46	6x36	8x47	s1p_off	8.77	0	No	No	No	No	9	8
47	6x39	7x56	s1p_off	4.56	0	No	No	No	No	6	7
48	6x40	7x49	s1p_off	5.91	0	No	No	Yes	Yes	8	9
49	6x48	6x52	s1p_off	7.02	0	Yes	Yes	Yes	Yes	8	6
50	6x54	7x34	s1p_off	4.73	0	No	No	No	No	4	4
51	7x35	Lig	s1p_off	4.52	0	No	No	Yes	Yes	3	0
52	7x45	7x48	s1p_off	5.85	0	Yes	Yes	No	No	9	5
53	7x49	7x53	s1p_off	4.65	0	Yes	Yes	Yes	Yes	9	9
54	7x53	8x50	s1p_off	7.18	0	Yes	Yes	No	No	9	8
55	7x54	8x51	s1p_off	6.47	0	No	No	No	No	7	8
56	7x54	8x54	s1p_off	5.19	0	No	No	No	No	7	7
57	8x59	CT	s1p_off	5.13	0	No	No	No	No	4	5
58	CT	CT	s1p_off	4.32	0	No	No	No	No	5	5
59	4x58	4x61	s1p_off	3.53	0	No	No	No	No	4	5
60	3x51	5x64	s1p_off	3.52	0	No	Yes	No	No	8	6
61	2x53	7x46	s1p_off	3.42	0	No	No	No	No	8	9
62	3x47	5x54	s1p_off	3.25	0	No	No	No	No	8	8
63	2x45	4x49	s1p_off	3.15	0	Yes	No	No	No	9	6
64	1x56	8x57	s1p_off	3.04	0	No	No	No	No	8	6
65	3x54	5x65	s1p_off	3.04	0	No	No	No	No	8	8
66	6x27	6x30	s1p_off	2.98	0	No	No	No	No	4	7
67	7x39	7x43	s1p_off	2.98	0	No	No	No	No	5	6
68	5x45	5x49	s1p_off	2.95	0	No	No	No	No	4	5
69	1x47	1x51	s1p_off	2.94	0	No	No	No	No	6	4
70	3x48	3x52	s1p_off	2.94	0	No	No	No	No	6	4
71	4x52	4x56	s1p_off	2.85	0	No	No	No	No	4	5
72	3x54	5x64	s1p_off	2.83	0	No	No	No	No	8	6
73	4x38	4x39	s1p_off	2.72	0	No	No	No	No	7	1
74	1x35	1x39	s1p_off	2.59	0	No	No	Yes	Yes	5	6
75	7x30	7x37	s1p_off	2.51	0	No	No	No	No	3	4
76	7x33	NT	s1p_off	2.48	0	No	No	Yes	Yes	4	6
77	7x32	E3	s1p_off	2.48	0	No	No	Yes	Yes	1	2
78	3x34	4x50	s1p_off	2.45	0	No	No	Yes	Yes	5	9
79	1x43	2x54	s1p_off	1.96	0	No	No	No	No	5	7
80	2x44	2x47	s1p_off	1.95	0	No	No	No	No	5	9
81	1x47	2x54	s1p_off	1.76	0	No	No	No	No	6	7
82	6x24	6x27	s1p_off	1.71	0	No	No	No	No	2	4
83	6x24	6x28	s1p_off	1.71	0	No	No	No	No	2	5
84	1x40	1x44	s1p_off	1.64	0	No	No	No	No	3	5
85	1x36	1x37	s1p_off	1.62	0	No	No	No	No	5	5
86	3x47	5x57	s1p_off	1.58	0	No	No	No	No	8	7
87	1x31	1x32	s1p_off	1.55	0	No	No	No	No	2	4
88	6x38	6x42	s1p_off	1.55	0	Yes	No	No	No	5	5
89	1x38	1x42	s1p_off	1.54	0	No	No	No	No	5	6
90	1x56	1x57	s1p_off	1.52	0	No	No	No	No	8	7
91	1x60	8x57	s1p_off	1.52	0	No	No	No	No	6	6
92	3x27	3x31	s1p_off	1.5	0	No	No	No	No	4	4
93	3x30	E2	s1p_off	1.45	0	No	No	Yes	Yes	6	4
94	6x41	6x45	s1p_off	1.43	0	No	No	No	No	7	6
95	6x53	6x57	s1p_off	1.43	0	No	No	No	No	5	4
96	4x59	4x62	s1p_off	1.41	0	No	No	No	No	5	4
97	1x29	1x32	s1p_off	1.37	0	No	No	No	No	3	4
98	6x25	6x26	s1p_off	1.32	0	No	No	No	Yes	4	4
99	4x43	4x46	s1p_off	1.26	0	No	No	No	No	2	7
100	2x41	4x46	s1p_off	1.21	0	No	No	No	No	4	7
101	5x62	6x38	s1p_off	1.21	0	No	Yes	Yes	No	6	5
102	NT	NT	Shared	75.32	32.004	Yes	Yes	Yes	Yes	6	6
103	E2	NT	Shared	108.8	65.4676	Yes	Yes	Yes	Yes	4	6
104	3x22	NT	Shared	5.08	5.01229	No	No	Yes	Yes	3	6
105	E1x501	NT	Shared	24.12	13.4804	No	No	Yes	Yes	5	6
106	3x25	NT	Shared	14.55	5.75344	Yes	Yes	Yes	Yes	9	6
107	Lig	NT	Shared	8.95	4.71771	Yes	Yes	Yes	Yes	0	6
108	E3	NT	Shared	14.85	7.18573	Yes	Yes	Yes	Yes	2	6
109	1x39	7x39	Shared	10.49	5.10094	Yes	Yes	No	No	6	5
110	1x43	2x57	Shared	4.03	3.06302	No	No	Yes	Yes	5	6
111	1x43	2x58	Shared	5.07	3.2525	No	No	No	No	5	6
112	1x45	1x49	Shared	12.83	3.25458	No	No	Yes	No	4	8
113	1x46	7x47	Shared	7.05	5.92135	No	No	No	No	7	7
114	1x49	7x50	Shared	14.15	3.7474	Yes	No	No	No	8	9
115	1x49	7x51	Shared	6.83	1.8849	Yes	No	No	No	8	6
116	1x50	2x50	Shared	5.39	10.3775	No	No	No	Yes	9	9
117	1x50	2x51	Shared	6.87	3.70396	No	No	No	No	9	6
118	1x50	7x50	Shared	4.89	5.71948	No	No	No	No	9	9
119	1x52	8x54	Shared	8.57	2.03208	No	No	No	No	7	7
120	1x56	8x54	Shared	3.89	1.66531	No	No	No	No	8	7
121	1x57	2x40	Shared	4.84	4.47833	No	No	No	Yes	7	9
122	1x60	I1x50	Shared	11.67	3.28281	No	No	Yes	Yes	6	8
123	2x40	I1x50	Shared	28.88	7.47875	No	Yes	Yes	Yes	9	8
124	8x53	I1x50	Shared	4.16	0.779375	No	No	Yes	Yes	7	8
125	2x37	2x40	Shared	4.12	2.76604	No	No	No	Yes	7	9
126	2x39	3x49	Shared	10.83	3.75052	Yes	No	Yes	Yes	8	9
127	2x42	3x45	Shared	8.32	2.4725	No	Yes	No	No	8	7
128	2x42	3x49	Shared	4.66	8.23542	No	Yes	Yes	Yes	8	9
129	2x45	4x46	Shared	12.74	6.53427	Yes	No	No	No	9	7
130	2x45	4x50	Shared	6.78	5.1125	Yes	No	Yes	Yes	9	9
131	2x46	3x42	Shared	6.01	7.05594	No	Yes	No	No	9	8
132	2x46	3x43	Shared	4.15	4.06708	No	Yes	No	No	9	9
133	2x46	7x49	Shared	4.12	3.50552	No	Yes	Yes	Yes	9	9
134	2x50	7x46	Shared	10.31	7.28375	No	Yes	No	No	9	9
135	2x50	7x49	Shared	6.73	3.29625	No	Yes	Yes	Yes	9	9
136	2x57	2x61	Shared	10.55	6.40833	Yes	Yes	Yes	Yes	6	5
137	2x57	3x32	Shared	5.99	3.55406	Yes	Yes	No	No	6	6
138	2x57	7x42	Shared	17.66	4.98479	Yes	Yes	No	No	6	7
139	2x60	3x28	Shared	7.23	5.93969	Yes	No	Yes	Yes	5	6
140	2x60	Lig	Shared	9.36	9.2251	Yes	No	Yes	Yes	5	0
141	2x64	Lig	Shared	4.09	3.54552	No	No	Yes	Yes	4	0
142	3x28	E1x50	Shared	6.47	3.53021	Yes	Yes	No	No	6	5
143	3x24	E1x52	Shared	9.32	9.23854	No	No	No	No	4	5
144	3x21	3x24	Shared	15.59	2.58125	No	No	No	No	7	4
145	3x25	3x28	Shared	12	7.625	Yes	Yes	Yes	Yes	9	6
146	3x25	3x29	Shared	7.63	14.0959	Yes	Yes	Yes	Yes	9	5
147	3x25	E2	Shared	28.02	17.4941	Yes	Yes	Yes	Yes	9	4
148	3x26	E2	Shared	22.01	13.8782	No	No	Yes	Yes	6	4
149	3x28	3x29	Shared	12.79	6.05885	Yes	Yes	Yes	Yes	6	5
150	3x29	E2	Shared	7.35	12.1239	Yes	Yes	Yes	Yes	5	4
151	3x29	Lig	Shared	18.97	7.49458	Yes	Yes	Yes	Yes	5	0
152	3x33	E2	Shared	15.85	3.38417	Yes	Yes	Yes	Yes	5	4
153	3x33	5x39	Shared	4.13	8.70396	Yes	Yes	Yes	Yes	5	7
154	3x33	5x43	Shared	4.19	3.23083	Yes	Yes	No	No	5	6
155	3x33	Lig	Shared	14.94	10.5074	Yes	Yes	Yes	Yes	5	0
156	3x36	6x48	Shared	15.94	5.79917	No	No	Yes	Yes	6	8
157	3x36	Lig	Shared	4.72	6.77688	No	No	Yes	Yes	6	0
158	3x37	4x53	Shared	6.52	2.95875	No	No	No	No	6	8
159	3x38	4x50	Shared	7.78	4.46948	No	No	Yes	Yes	7	9
160	3x40	5x50	Shared	4.47	3.06604	No	No	No	No	7	8
161	3x41	4x52	Shared	3.77	4.24323	No	No	No	No	5	4
162	3x44	3x48	Shared	7.14	2.83844	No	Yes	No	No	7	6
163	3x44	5x54	Shared	4.28	4.53406	No	Yes	No	No	7	8
164	3x47	5x58	Shared	5.34	4.34979	No	No	No	Yes	8	9
165	3x49	3x53	Shared	4.23	2.54177	Yes	Yes	No	No	9	8
166	3x51	5x61	Shared	6.04	2.49302	No	Yes	No	No	8	9
167	4x38	4x41	Shared	7.23	4.05906	No	No	No	No	7	5
168	4x40	4x44	Shared	7.31	0.723125	No	No	No	No	4	3
169	4x59	5x39	Shared	8.21	5.18813	No	No	Yes	Yes	5	7
170	4x60	E2	Shared	5.56	8.63385	No	No	Yes	Yes	5	4
171	4x60	5x39	Shared	13.91	13.0413	No	No	Yes	Yes	5	7
172	5x36	E2	Shared	19.47	6.29042	No	No	Yes	Yes	4	4
173	5x39	E2	Shared	20.37	9.61417	Yes	Yes	Yes	Yes	7	4
174	E2	E2	Shared	42.98	45.9714	Yes	Yes	Yes	Yes	4	4
175	6x58	E2	Shared	17.5	13.4871	No	No	Yes	Yes	4	4
176	7x31	E2	Shared	4.42	6.63156	Yes	Yes	Yes	Yes	3	4
177	5x36	5x38	Shared	9.55	4.195	No	No	No	No	4	4
178	5x39	5x43	Shared	9.41	3.15042	Yes	Yes	No	No	7	6
179	5x40	6x55	Shared	7.14	2.5324	No	No	No	No	6	6
180	5x41	6x59	Shared	8.94	2.62906	No	No	No	No	5	4
181	5x42	5x46	Shared	3.93	2.63115	No	No	No	No	5	5
182	5x44	6x52	Shared	3.89	4.0251	No	No	Yes	Yes	5	6
183	5x47	6x52	Shared	4.29	12.9503	Yes	No	Yes	Yes	7	6
184	5x51	6x44	Shared	6.09	2.98208	No	No	Yes	No	5	9
185	5x58	6x37	Shared	3.79	3.11677	No	Yes	No	No	9	8
186	6x34	6x38	Shared	4.28	3.10021	No	No	Yes	No	8	5
187	6x36	7x56	Shared	6.28	1.1775	No	No	No	No	9	7
188	6x44	6x48	Shared	15.03	6.36875	Yes	No	Yes	Yes	9	8
189	6x44	7x45	Shared	7.25	4.88417	Yes	No	Yes	Yes	9	9
190	6x47	7x45	Shared	9.45	5.72448	No	No	Yes	Yes	8	9
191	6x48	7x41	Shared	10.37	3.67594	Yes	Yes	No	No	8	7
192	6x48	7x45	Shared	4.52	11.4766	Yes	Yes	Yes	Yes	8	9
193	6x51	6x55	Shared	4.15	4.04865	No	No	No	No	6	6
194	6x54	7x37	Shared	10.96	12.2665	No	No	No	No	4	4
195	6x58	7x31	Shared	12.21	6.85656	No	No	Yes	Yes	4	3
196	6x61	E3	Shared	8.97	10.5888	No	No	Yes	Yes	4	2
197	E3	E3	Shared	9.07	8.47812	Yes	Yes	Yes	Yes	2	2
198	7x31	E3	Shared	6.35	3.8151	Yes	Yes	Yes	Yes	3	2
199	7x33	7x36	Shared	9.26	5.97875	No	No	No	No	4	3
200	7x38	Lig	Shared	19.81	6.66594	No	No	Yes	Yes	5	0
201	8x47	8x50	Shared	15.43	3.26562	No	No	No	No	8	8
202	8x48	8x51	Shared	6.19	1.76594	No	No	No	No	6	8
203	2x49	4x50	Shared	3.71	3.26677	No	No	Yes	Yes	8	9
204	2x64	E1x47	Shared	3.71	0.947292	No	No	No	No	4	4
205	2x42	4x42	Shared	3.65	5.9249	No	Yes	No	Yes	8	7
206	3x41	5x50	Shared	3.65	4.51552	No	No	No	No	5	8
207	2x52	4x50	Shared	3.42	2.22062	No	No	Yes	Yes	6	9
208	1x53	2x47	Shared	3.39	2.44677	No	No	No	No	9	9
209	6x43	7x48	Shared	3.17	2.79083	No	No	No	No	7	5
210	1x54	2x47	Shared	3.15	2.70865	No	No	No	No	8	9
211	6x40	7x52	Shared	3.07	2.69	No	No	No	Yes	8	8
212	1x36	2x61	Shared	3	2.34958	No	No	Yes	Yes	5	5
213	3x34	4x54	Shared	2.98	2.7949	No	No	No	No	5	4
214	1x59	8x57	Shared	2.91	3.41844	No	Yes	No	No	6	6
215	6x50	7x37	Shared	2.89	2.93469	No	No	No	No	9	4
216	1x40	2x61	Shared	2.85	3.25646	No	No	Yes	Yes	3	5
217	6x54	7x31	Shared	2.77	1.42812	No	No	Yes	Yes	4	3
218	5x48	6x52	Shared	2.59	2.33865	No	No	Yes	Yes	4	6
219	3x26	4x61	Shared	2.51	4.81313	No	No	No	No	6	5
220	1x39	2x61	Shared	2.44	3.26229	Yes	Yes	Yes	Yes	6	5
221	6x26	6x29	Shared	2.33	1.80833	No	Yes	Yes	No	4	6
222	4x57	4x58	Shared	2.11	1.055	No	No	No	No	6	4
223	6x49	6x50	Shared	1.87	3.04417	No	No	No	No	6	9
224	2x53	3x35	Shared	1.79	1.7625	No	No	No	No	8	6
225	2x56	3x31	Shared	1.71	0.961875	No	No	No	No	4	4
226	4x63	E2	Shared	1.7	1.60104	No	No	Yes	Yes	5	4
227	3x21	3x23	Shared	1.68	2.15	No	No	No	No	7	2
228	6x50	7x40	Shared	1.64	5.3526	No	No	No	No	9	7
229	2x56	3x32	Shared	1.61	1.23323	No	No	No	No	4	6
230	1x47	2x55	Shared	1.54	2.3224	No	No	No	No	6	5
231	4x51	4x55	Shared	1.54	1.00271	No	No	No	No	4	4
232	5x40	6x59	Shared	1.54	2.05875	No	No	No	No	6	4
233	5x37	E2	Shared	1.53	3.42427	No	No	Yes	Yes	3	4
234	1x33	1x37	Shared	1.52	1.1125	No	No	No	No	4	5
235	5x55	6x41	Shared	1.49	2.36198	No	No	No	No	4	7
236	7x54	7x55	Shared	1.47	1.10594	No	No	No	No	7	6
237	6x28	6x29	Shared	1.44	0.527188	No	No	Yes	No	5	6
238	5x51	6x45	Shared	1.43	2.51281	No	No	No	No	5	6
239	8x51	8x55	Shared	1.25	0.713333	No	No	No	No	8	3
240	1x58	1x59	Shared	1.16	1.39	No	No	No	Yes	3	6
241	1x47	2x51	s1p_on	0	3.18083	No	No	No	No	6	6
242	1x53	7x50	s1p_on	0	3.38719	No	No	No	No	9	9
243	1x57	2x44	s1p_on	0	3.06083	No	No	No	No	7	5
244	1x59	1x60	s1p_on	0	3.94792	No	Yes	No	No	6	6
245	2x38	4x42	s1p_on	0	4.09188	No	No	No	Yes	7	7
246	2x40	8x50	s1p_on	0	2.99292	No	Yes	No	No	9	8
247	2x41	4x42	s1p_on	0	4.81229	No	No	No	Yes	4	7
248	2x42	3x46	s1p_on	0	4.50115	No	Yes	No	No	8	8
249	2x42	4x45	s1p_on	0	4.00531	No	Yes	No	No	8	6
250	2x46	2x50	s1p_on	0	3.91521	No	Yes	No	Yes	9	9
251	2x49	3x38	s1p_on	0	3.21063	No	No	No	No	8	7
252	2x57	7x38	s1p_on	0	6.36479	Yes	Yes	No	No	6	5
253	2x63	3x28	s1p_on	0	6.3525	No	No	Yes	Yes	4	6
254	3x21	3x22	s1p_on	0	3.63938	No	No	No	No	7	3
255	3x25	3x26	s1p_on	0	5.28354	Yes	Yes	No	No	9	6
256	3x37	Lig	s1p_on	0	6.13615	No	No	Yes	Yes	6	0
257	3x40	6x48	s1p_on	0	4.08438	No	No	Yes	Yes	7	8
258	3x41	4x49	s1p_on	0	3.09688	No	No	No	No	5	6
259	3x43	7x49	s1p_on	0	4.3774	No	No	Yes	Yes	9	9
260	3x43	7x53	s1p_on	0	4.41042	No	No	Yes	Yes	9	9
261	3x44	5x50	s1p_on	0	5.95917	No	Yes	No	No	7	8
262	3x46	3x50	s1p_on	0	4.61938	No	No	Yes	No	8	9
263	3x46	7x53	s1p_on	0	4.40938	No	No	Yes	Yes	8	9
264	3x50	7x53	s1p_on	0	6.07656	Yes	No	Yes	Yes	9	9
265	3x51	5x57	s1p_on	0	5.97906	No	Yes	No	No	8	7
266	3x51	5x60	s1p_on	0	7.65292	No	Yes	No	No	8	5
267	3x52	4x41	s1p_on	0	5.49615	No	No	No	No	4	5
268	3x54	5x61	s1p_on	0	3.80813	No	No	No	No	8	9
269	3x56	I2x51	s1p_on	0	5.07167	No	No	No	No	6	7
270	4x59	E2	s1p_on	0	4.20062	No	No	Yes	Yes	5	4
271	E2	Lig	s1p_on	0	3.95656	Yes	Yes	Yes	Yes	4	0
272	5x47	6x48	s1p_on	0	7.54646	Yes	No	Yes	Yes	7	8
273	5x47	Lig	s1p_on	0	4.48365	Yes	No	Yes	Yes	7	0
274	5x58	6x41	s1p_on	0	5.2751	No	Yes	No	No	9	7
275	5x58	7x53	s1p_on	0	3.06969	No	Yes	Yes	Yes	9	9
276	5x62	5x66	s1p_on	0	5.58448	No	Yes	No	Yes	6	5
277	5x62	6x34	s1p_on	0	11.5764	No	Yes	No	No	6	8
278	6x43	7x52	s1p_on	0	3.4575	No	No	No	Yes	7	8
279	6x51	Lig	s1p_on	0	3.39854	No	No	Yes	Yes	6	0
280	7x35	7x36	s1p_on	0	4.46771	No	No	No	No	3	3
281	7x45	7x49	s1p_on	0	7.5351	Yes	Yes	Yes	Yes	9	9
282	7x52	7x53	s1p_on	0	3.26417	No	Yes	Yes	Yes	8	9
283	1x39	2x57	s1p_on	0	3.22865	Yes	Yes	Yes	Yes	6	6
284	2x60	3x32	s1p_on	0	3.74365	Yes	No	No	No	5	6
285	E1x50	E1x501	s1p_on	0	3.00125	No	No	No	No	5	5
286	3x40	Lig	s1p_on	0	3.18271	No	No	Yes	Yes	7	0
287	3x50	5x58	s1p_on	0	5.71062	Yes	No	No	Yes	9	9
288	5x38	E2	s1p_on	0	5.57292	No	No	Yes	Yes	4	4
289	5x43	Lig	s1p_on	0	4.72271	No	No	Yes	Yes	6	0
290	6x48	Lig	s1p_on	0	3.52781	Yes	Yes	Yes	Yes	8	0
291	6x52	6x56	s1p_on	0	4.09729	Yes	Yes	No	No	6	6
292	3x49	4x41	s1p_on	0	4.96812	Yes	Yes	No	No	9	5
293	1x32	7x35	s1p_on	0	4.5125	No	No	No	No	4	3
294	2x40	I1x51	s1p_on	0	5.1825	No	Yes	No	No	9	7
295	5x62	6x35	s1p_on	0	4.18	No	Yes	No	No	6	7
296	7x42	7x46	s1p_on	0	3.21844	No	No	No	No	7	9
297	3x56	I2x54	s1p_on	0	4.3225	No	No	No	No	6	4
298	2x40	8x49	s1p_on	0	2.88802	No	Yes	No	No	9	7
299	3x38	4x53	s1p_on	0	2.8099	No	No	No	No	7	8
300	1x46	7x46	s1p_on	0	2.80687	No	No	No	No	7	9
301	5x62	6x33	s1p_on	0	2.78396	No	Yes	No	No	6	8
302	3x48	5x57	s1p_on	0	2.73729	No	No	No	No	6	7
303	5x64	5x68	s1p_on	0	2.59531	No	No	No	No	6	7
304	4x38	I2x56	s1p_on	0	2.49406	No	No	No	No	7	7
305	2x50	3x39	s1p_on	0	2.48406	No	Yes	No	No	9	9
306	7x54	8x50	s1p_on	0	2.4776	No	No	No	No	7	8
307	3x34	4x53	s1p_on	0	2.4725	No	No	No	No	5	8
308	5x65	6x33	s1p_on	0	2.46781	No	No	No	No	8	8
309	1x57	2x43	s1p_on	0	2.42219	No	No	No	No	7	8
310	1x51	2x51	s1p_on	0	2.34552	No	No	No	No	4	6
311	5x68	I2x50	s1p_on	0	2.2875	No	No	No	No	7	8
312	2x37	2x39	s1p_on	0	2.17167	No	No	Yes	No	7	8
313	4x56	5x39	s1p_on	0	2.17167	No	No	Yes	Yes	5	7
314	7x34	E2	s1p_on	0	2.13698	No	No	Yes	Yes	4	4
315	5x66	6x30	s1p_on	0	2.095	No	Yes	No	No	5	7
316	I1x49	I1x50	s1p_on	0	2.0925	No	No	Yes	Yes	6	8
317	6x47	7x43	s1p_on	0	2.0925	No	No	No	No	8	6
318	3x44	5x53	s1p_on	0	2.04313	No	Yes	No	No	7	6
319	3x53	I2x53	s1p_on	0	2.0025	No	No	No	No	8	7
320	3x53	3x56	s1p_on	0	1.94	No	No	No	No	8	6
321	6x57	E3	s1p_on	0	1.90958	No	No	Yes	Yes	4	2
322	2x39	7x56	s1p_on	0	1.8825	Yes	No	No	No	8	7
323	5x66	5x70	s1p_on	0	1.87813	No	Yes	No	No	5	0
324	5x69	6x26	s1p_on	0	1.8625	No	No	No	Yes	0	4
325	1x42	1x46	s1p_on	0	1.82938	No	No	No	No	6	7
326	4x39	4x42	s1p_on	0	1.80094	No	No	No	Yes	1	7
327	I2x52	I2x53	s1p_on	0	1.79667	No	No	No	No	4	7
328	6x33	6x37	s1p_on	0	1.77896	No	No	No	No	8	8
329	4x42	4x43	s1p_on	0	1.775	No	Yes	No	No	7	2
330	4x56	5x42	s1p_on	0	1.75635	No	No	No	No	5	5
331	7x32	NT	s1p_on	0	1.74219	No	No	Yes	Yes	1	6
332	1x35	7x33	s1p_on	0	1.6325	No	No	No	No	5	4
333	6x23	6x26	s1p_on	0	1.47583	No	No	No	Yes	0	4
334	2x52	3x35	s1p_on	0	1.44969	No	No	No	No	6	6
335	1x39	7x35	s1p_on	0	1.43802	Yes	Yes	No	No	6	3
336	1x54	2x48	s1p_on	0	1.42812	No	No	No	No	8	5
337	5x48	5x49	s1p_on	0	1.41906	No	No	No	No	4	5
338	7x29	E3	s1p_on	0	1.41	No	No	Yes	Yes	3	2
339	2x53	2x54	s1p_on	0	1.40156	No	No	No	No	8	7
340	5x56	5x60	s1p_on	0	1.3575	No	No	No	No	4	5
341	1x55	1x59	s1p_on	0	1.31083	No	No	No	Yes	4	6
342	3x51	3x55	s1p_on	0	1.28448	No	Yes	No	No	8	6
343	3x30	3x33	s1p_on	0	1.2426	No	No	Yes	Yes	6	5
344	3x33	4x57	s1p_on	0	1.2426	Yes	Yes	No	No	5	6
345	1x38	1x39	s1p_on	0	1.20563	No	No	Yes	Yes	5	6
346	6x27	6x28	s1p_on	0	1.19687	No	No	No	No	4	5
347	6x53	6x56	s1p_on	0	1.10844	No	No	No	No	5	6
348	8x48	8x52	s1p_on	0	1.07042	No	No	No	No	6	5
349	7x30	7x31	s1p_on	0	1.05479	No	No	Yes	Yes	3	3
350	4x61	4x62	s1p_on	0	1.05125	No	No	No	No	5	4
351	5x62	5x63	s1p_on	0	1.0325	No	Yes	No	No	6	3
352	E1x47	E1x48	s1p_on	0	1.015	No	No	No	No	4	4
353	E1x49	E1x51	s1p_on	0	0.911563	No	No	No	No	4	1
354	5x66	6x31	s1p_on	0	0.91	No	Yes	No	No	5	5
355	6x39	7x52	s1p_on	0	0.88875	No	No	No	Yes	6	8
356	6x26	I3	s1p_on	0	0.8625	No	Yes	No	No	4	0
357	3x27	4x61	s1p_on	0	0.836354	No	No	No	No	4	5
358	4x39	4x40	s1p_on	0	0.805	No	No	No	No	1	4
359	5x72	5x74	s1p_on	0	0.799062	No	No	No	No	0	0
360	1x56	1x59	s1p_on	0	0.78625	No	No	No	Yes	8	6
361	5x55	5x59	s1p_on	0	0.774063	No	No	No	No	4	3
362	1x47	1x48	s1p_on	0	0.7725	No	No	No	No	6	4
363	5x41	5x45	s1p_on	0	0.7375	No	No	No	No	5	4
364	8x54	8x55	s1p_on	0	0.710104	No	No	No	No	7	3
365	4x48	4x52	s1p_on	0	0.709583	No	No	No	No	3	4
366	2x58	2x62	s1p_on	0	0.699688	No	No	No	No	6	6
367	1x33	1x34	s1p_on	0	0.6925	No	No	No	No	4	4
368	3x55	5x64	s1p_on	0	0.680729	No	No	No	No	6	6
369	E1x48	E1x49	s1p_on	0	0.649167	No	No	No	No	4	4
370	I1x48	I1x51	s1p_on	0	0.573125	No	No	No	No	6	7
371	6x25	6x28	s1p_on	0	0.546667	No	No	No	No	4	5
372	5x73	I3	s1p_on	0	0.509688	No	No	No	No	0	0
373	1x32	1x34	s1p_on	0	0.5	No	No	No	No	4	4
374	5x49	5x52	s1p_on	0	0.4875	No	No	No	No	5	4
375	5x67	5x71	s1p_on	0	0.485312	No	No	No	No	5	0
376	4x46	4x47	s1p_on	0	0.44	No	No	No	No	7	4
377	2x59	2x63	s1p_on	0	0.429375	No	No	No	No	7	4
378	4x51	4x54	s1p_on	0	0.4275	No	No	No	No	4	4
379	6x24	6x25	s1p_on	0	0.425833	No	No	No	No	2	4
380	I2x55	I2x56	s1p_on	0	0.425625	No	No	No	No	4	7
381	5x65	5x69	s1p_on	0	0.421875	No	No	No	No	8	0
382	1x37	1x41	s1p_on	0	0.406354	No	No	No	No	5	4
383	1x31	1x34	s1p_on	0	0.405	No	No	No	No	2	4
384	1x30	1x31	s1p_on	0	0.4	No	No	No	No	4	2
385	5x68	5x72	s1p_on	0	0.380313	No	No	No	No	7	0
386	1x41	1x44	s1p_on	0	0.368229	No	No	No	No	4	5
387	8x56	8x57	s1p_on	0	0.342396	No	No	No	No	4	6
388	5x71	5x72	s1p_on	0	0.341563	No	No	No	No	0	0
389	6x59	6x60	s1p_on	0	0.2875	No	No	No	No	4	4
390	6x42	6x43	s1p_on	0	0.151875	No	No	No	No	5	7
391	6x32	6x35	s1p_on	0	0.115	No	No	No	No	7	7

Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	s1p_off Avg Int. Strength	s1p_on Avg Int. Strength	s1p_off Num Of Links	s1p_on Num Of Links	ConSurf
1	1x49	s1p_off	9.68	2.96229	4	3	8
2	2x39	s1p_off	8.0175	2.60156	4	3	8
3	2x45	s1p_off	7.53	5.82339	4	2	9
4	2x60	s1p_off	7.535	6.30281	4	3	5
5	3x50	s1p_off	10.3475	5.46885	4	3	9
6	5x47	s1p_off	5.5775	8.32681	4	3	7
7	6x29	s1p_off	5.465	1.16776	4	2	6
8	6x38	s1p_off	2.97	3.10021	4	1	5
9	6x44	s1p_off	9.225	4.745	4	3	9
10	NT	Shared	29.2983	18.5964	12	9	6
11	1x39	Shared	4.8225	2.8471	4	5	6
12	I1x50	Shared	12.11	3.40836	4	4	8
13	2x57	Shared	9.042	4.60061	5	6	6
14	2x61	Shared	4.71	3.81917	4	4	5
15	3x25	Shared	15.55	10.0504	4	5	9
16	3x28	Shared	8.19167	5.90125	6	5	6
17	3x29	Shared	10.662	9.94331	5	4	5
18	3x33	Shared	9.7775	4.71859	4	6	5
19	3x49	Shared	8.42	4.87396	4	4	9
20	4x50	Shared	4.97167	3.76734	6	4	9
21	E2	Shared	20.8924	14.9911	17	18	4
22	5x39	Shared	11.206	6.97826	5	6	7
23	6x48	Shared	10.576	6.06844	5	7	8
24	6x52	Shared	4.4475	5.85284	4	4	6
25	E3	Shared	8.465	5.98077	6	7	2
26	7x31	Shared	6.4375	3.95723	4	5	3
27	7x45	Shared	6.7675	7.40508	4	4	9
28	7x49	Shared	5.3525	4.67857	4	4	9
29	7x53	Shared	5.43	4.24604	4	5	9
30	Lig	Shared	10.561	5.5958	10	14	0
31	1x59	s1p_on	2.035	2.17069	2	5	6
32	2x40	s1p_on	12.6133	4.29776	3	6	9
33	2x42	s1p_on	5.54333	5.02785	3	5	8
34	2x46	s1p_on	4.76	4.63594	3	4	9
35	2x50	s1p_on	7.47667	5.47135	3	5	9
36	3x44	s1p_on	5.71	3.8437	2	4	7
37	3x51	s1p_on	4.78	4.35237	2	4	8
38	4x42	s1p_on	3.65	3.681	1	5	7
39	5x58	s1p_on	4.65667	4.3044	3	5	9
40	5x62	s1p_on	1.21	5.03146	1	5	6
41	5x66	s1p_on	0	2.6169	0	4	5
42	6x26	s1p_on	1.825	1.50229	2	4	4
43	7x52	s1p_on	3.07	2.5751	1	4	8

Orange: nodes, hubs and links specific of s1p_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	s1p_off Recurrence	s1p_on Recurrence	s1p_off Hub1?	s1p_on Hub1?	s1p_off Hub2?	s1p_on Hub2?	ConSurf1	ConSurf2
1	2x57	2x61	s1p_off	19.3468	5.25616	Yes	Yes	Yes	Yes	6	5
2	2x57	2x60	s1p_off	17.328	0	Yes	Yes	Yes	No	6	5
3	2x60	Lig	s1p_off	14.6609	7.69506	Yes	No	Yes	Yes	5	0
4	2x57	3x32	s1p_off	14.2916	4.7193	Yes	Yes	No	No	6	6
5	3x32	Lig	s1p_off	18.4112	0	No	No	Yes	Yes	6	0
6	2x46	7x49	s1p_off	74.601	1.3754	No	Yes	Yes	Yes	9	9
7	3x43	6x44	s1p_off	83.3162	0	No	No	Yes	No	9	9
8	6x44	6x48	s1p_off	96.8118	2.35709	Yes	No	Yes	Yes	9	8
9	3x36	6x48	s1p_off	96.5656	0.782289	No	No	Yes	Yes	6	8
10	3x36	Lig	s1p_off	100	0.787402	No	No	Yes	Yes	6	0
11	1x56	8x54	s1p_off	21.0373	8.32907	No	No	No	No	8	7
12	1x56	8x57	s1p_off	11.8666	0	No	No	No	No	8	6
13	1x60	8x57	s1p_off	15.4405	0	No	No	No	No	6	6
14	8x50	I1x50	s1p_off	35.5299	0	No	No	Yes	Yes	8	8
15	7x53	8x50	s1p_off	45.9522	0	Yes	Yes	No	No	9	8
16	7x49	7x53	s1p_off	65.5862	0	Yes	Yes	Yes	Yes	9	9
17	1x56	1x57	s1p_off	11.8666	0	No	No	No	No	8	7
18	1x57	2x40	s1p_off	13.1222	4.88803	No	No	No	Yes	7	9
19	6x29	8x49	s1p_off	17.369	0	Yes	No	No	No	6	7
20	6x33	8x49	s1p_off	19.3878	0	No	No	No	No	8	7
21	2x39	6x33	s1p_off	14.3818	0	Yes	No	No	No	8	8
22	2x39	2x43	s1p_off	22.4939	0	Yes	No	No	No	8	8
23	2x43	7x53	s1p_off	23.4418	0	No	No	Yes	Yes	8	9
24	6x33	8x47	s1p_off	14.6404	0	No	No	No	No	8	8
25	8x47	8x50	s1p_off	19.3139	1.31404	No	No	No	No	8	8
26	2x45	3x42	s1p_off	17.4018	0	Yes	No	No	No	9	8
27	2x46	3x42	s1p_off	18.6082	1.39585	No	Yes	No	No	9	8
28	2x45	4x50	s1p_off	10.3361	4.15175	Yes	No	Yes	Yes	9	9
29	3x29	Lig	s1p_off	18.2143	5.28173	Yes	Yes	Yes	Yes	5	0
30	3x33	Lig	s1p_off	21.7677	8.87105	Yes	Yes	Yes	Yes	5	0
31	E2	NT	s1p_off	18.8216	1.54413	Yes	Yes	Yes	Yes	4	6
32	3x33	E2	s1p_off	17.2828	0.966357	Yes	Yes	Yes	Yes	5	4
33	3x36	5x47	s1p_off	12.002	0	No	No	Yes	No	6	7
34	5x54	6x41	s1p_off	18.9487	0	No	No	No	No	8	7
35	6x41	6x45	s1p_off	20.8116	0	No	No	No	No	7	6
36	5x51	6x45	s1p_off	21.8415	1.39585	No	No	No	No	5	6
37	5x51	6x44	s1p_off	22.9535	2.78658	No	No	Yes	No	5	9
38	3x47	5x58	s1p_off	11.645	1.91737	No	No	No	Yes	8	9
39	3x47	5x54	s1p_off	16.3719	0	No	No	No	No	8	8
40	2x39	3x50	s1p_off	11.1116	0	Yes	No	Yes	No	8	9
41	3x47	5x57	s1p_off	11.3208	0	No	No	No	No	8	7
42	5x40	E2	s1p_off	11.1772	0	No	No	Yes	Yes	6	4
43	5x58	6x38	s1p_off	10.213	0	No	Yes	Yes	No	9	5
44	6x54	7x31	s1p_off	20.3315	6.5702	No	No	Yes	Yes	4	3
45	7x31	E2	s1p_off	17.5906	8.88128	Yes	Yes	Yes	Yes	3	4
46	6x54	7x37	s1p_off	14.5624	5.53738	No	No	No	No	4	4
47	7x54	8x54	s1p_off	13.2083	0	No	No	No	No	7	7
48	3x29	E2	s1p_off	20.2577	0.603334	Yes	Yes	Yes	Yes	5	4
49	Lig	NT	Shared	34.1184	13.8409	Yes	Yes	Yes	Yes	0	6
50	1x50	2x50	Shared	10.533	25.4781	No	No	No	Yes	9	9
51	2x50	7x49	Shared	15.6046	32.4113	No	Yes	Yes	Yes	9	9
52	2x46	3x43	Shared	82.8403	21.3059	No	Yes	No	No	9	9
53	1x60	I1x50	Shared	16.7043	18.9794	No	No	Yes	Yes	6	8
54	2x40	I1x50	Shared	16.7535	23.1363	No	Yes	Yes	Yes	9	8
55	1x39	2x57	s1p_on	0	23.7908	Yes	Yes	Yes	Yes	6	6
56	2x57	7x38	s1p_on	0	16.5508	Yes	Yes	No	No	6	5
57	7x38	Lig	s1p_on	1.28842	17.4711	No	No	Yes	Yes	5	0
58	1x50	7x50	s1p_on	7.94797	14.8021	No	No	No	No	9	9
59	7x45	7x49	s1p_on	0	72.4409	Yes	Yes	Yes	Yes	9	9
60	6x48	7x45	s1p_on	3.13077	71.2598	Yes	Yes	Yes	Yes	8	9
61	6x48	Lig	s1p_on	0	54.0137	Yes	Yes	Yes	Yes	8	0
62	7x42	7x46	s1p_on	0	28.28	No	No	No	No	7	9
63	2x57	7x42	s1p_on	1.6536	27.9783	Yes	Yes	No	No	6	7
64	2x37	2x40	s1p_on	2.73686	38.6287	No	No	No	Yes	7	9
65	2x37	2x39	s1p_on	0	40.1421	No	No	Yes	No	7	8
66	2x39	3x49	s1p_on	6.081	44.1047	Yes	No	Yes	Yes	8	9
67	2x42	3x49	s1p_on	3.94321	60.3589	No	Yes	Yes	Yes	8	9
68	2x42	3x46	s1p_on	0	73.1874	No	Yes	No	No	8	8
69	3x46	7x53	s1p_on	0	67.9568	No	No	Yes	Yes	8	9
70	3x43	7x53	s1p_on	0	100	No	No	Yes	Yes	9	9
71	3x43	7x49	s1p_on	0	79.5173	No	No	Yes	Yes	9	9
72	1x59	1x60	s1p_on	0	17.7523	No	Yes	No	No	6	6
73	2x42	4x42	s1p_on	1.22687	12.307	No	Yes	No	Yes	8	7
74	3x38	4x50	s1p_on	1.31714	10.8344	No	No	Yes	Yes	7	9
75	3x38	4x53	s1p_on	0	13.4932	No	No	No	No	7	8
76	3x37	4x53	s1p_on	1.81773	19.8589	No	No	No	No	6	8
77	3x37	Lig	s1p_on	0	21.1013	No	No	Yes	Yes	6	0
78	3x40	Lig	s1p_on	0	15.6202	No	No	Yes	Yes	7	0
79	3x40	5x50	s1p_on	7.23401	29.819	No	No	No	No	7	8
80	3x44	5x50	s1p_on	0	23.53	No	Yes	No	No	7	8
81	5x58	7x53	s1p_on	0	37.6163	No	Yes	Yes	Yes	9	9
82	3x51	5x57	s1p_on	0	16.9854	No	Yes	No	No	8	7
83	3x48	5x57	s1p_on	0	18.3148	No	No	No	No	6	7
84	3x44	3x48	s1p_on	2.9092	19.6339	No	Yes	No	No	7	6
85	5x47	6x52	s1p_on	6.52004	10.589	Yes	No	Yes	Yes	7	6
86	5x62	6x33	s1p_on	0	18.2432	No	Yes	No	No	6	8
87	6x33	6x37	s1p_on	0	34.7173	No	No	No	No	8	8
88	5x58	6x37	s1p_on	2.85996	36.0262	No	Yes	No	No	9	8
89	1x39	7x35	s1p_on	0	18.8772	Yes	Yes	No	No	6	3
90	4x56	5x39	s1p_on	0	10.0061	No	No	Yes	Yes	5	7
91	3x51	3x55	s1p_on	0	10.1749	No	Yes	No	No	8	6
92	1x56	1x59	s1p_on	0	10.0828	No	No	No	Yes	8	6
93	5x69	6x26	s1p_on	0	13.2989	No	No	No	Yes	0	4
94	5x65	5x69	s1p_on	0	14.7254	No	No	No	No	8	0
95	5x65	6x33	s1p_on	0	16.1622	No	No	No	No	8	8
96	1x32	1x34	s1p_on	0	11.5605	No	No	No	No	4	4
97	1x32	7x35	s1p_on	0	12.7978	No	No	No	No	4	3
98	E2	Lig	s1p_on	0	24.9156	Yes	Yes	Yes	Yes	4	0
99	2x50	7x46	s1p_on	4.00886	30.2025	No	Yes	No	No	9	9
100	2x46	2x50	s1p_on	0	20.8559	No	Yes	No	Yes	9	9
101	3x40	6x48	s1p_on	0	15.4208	No	No	Yes	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	75.32	32.004	1	1	1	1
E2	NT	Shared	108.8	65.4676	1	1	1	1
3x21	NT	s1p_off	11	0	1	0	2	1
3x22	NT	Shared	5.08	5.01229	0	1	2	1
E1x501	NT	Shared	24.12	13.4804	0	1	2	1
3x25	NT	Shared	14.55	5.75344	1	1	2	1
E1x50	NT	s1p_off	4.99	0	1	0	2	1
Lig	NT	Shared	8.95	4.71771	1	1	0	1
E3	NT	Shared	14.85	7.18573	1	1	2	1
1x31	NT	s1p_off	6.12	0	1	0	2	1
2x57	2x60	s1p_off	6.98	0	0	2	2	1
2x57	3x32	Shared	5.99	3.55406	0	2	2	1
2x60	3x28	Shared	7.23	5.93969	1	0	1	1
2x60	3x29	s1p_off	6.57	0	1	0	1	1
2x60	Lig	Shared	9.36	9.2251	1	0	1	0
2x63	E1x52	s1p_off	6.92	0	0	0	2	2
2x64	Lig	Shared	4.09	3.54552	0	0	1	0
3x28	E1x50	Shared	6.47	3.53021	1	1	1	2
3x28	E1x52	s1p_off	4.86	0	1	1	1	2
3x25	3x28	Shared	12	7.625	1	1	2	1
3x25	3x29	Shared	7.63	14.0959	1	1	2	1
3x25	E2	Shared	28.02	17.4941	1	1	2	1
3x26	E2	Shared	22.01	13.8782	1	1	2	1
3x28	3x29	Shared	12.79	6.05885	1	1	1	1
3x28	Lig	s1p_off	5.8	0	1	1	1	0
3x29	E2	Shared	7.35	12.1239	1	1	1	1
3x29	Lig	Shared	18.97	7.49458	1	1	1	0
3x32	Lig	s1p_off	14.45	0	0	0	1	0
3x33	E2	Shared	15.85	3.38417	1	1	1	1
3x33	5x39	Shared	4.13	8.70396	1	1	1	2
3x33	5x43	Shared	4.19	3.23083	1	1	1	1
3x33	Lig	Shared	14.94	10.5074	1	1	1	0
3x36	5x47	s1p_off	4.87	0	0	1	1	1
3x36	6x48	Shared	15.94	5.79917	0	1	1	1
3x36	Lig	Shared	4.72	6.77688	0	1	1	0
3x37	4x53	Shared	6.52	2.95875	0	0	1	2
3x37	5x47	s1p_off	5.28	0	0	0	1	1
3x40	5x47	s1p_off	7.87	0	0	1	1	1
3x40	5x50	Shared	4.47	3.06604	0	1	1	2
4x59	4x60	s1p_off	4.93	0	1	1	2	2
4x59	5x39	Shared	8.21	5.18813	1	1	2	2
4x60	E2	Shared	5.56	8.63385	1	1	2	1
4x60	5x39	Shared	13.91	13.0413	1	1	2	2
5x36	E2	Shared	19.47	6.29042	1	1	2	1
5x39	E2	Shared	20.37	9.61417	1	1	2	1
5x42	E2	s1p_off	8.02	0	1	0	2	1
E2	E2	Shared	42.98	45.9714	1	1	1	1
5x40	E2	s1p_off	7.16	0	1	0	2	1
6x58	E2	Shared	17.5	13.4871	1	1	2	1
7x31	E2	Shared	4.42	6.63156	1	1	2	1
5x36	5x38	Shared	9.55	4.195	1	1	2	2
5x39	5x43	Shared	9.41	3.15042	1	1	2	1
5x40	6x55	Shared	7.14	2.5324	1	0	2	2
5x47	6x52	Shared	4.29	12.9503	0	1	1	2
6x44	6x48	Shared	15.03	6.36875	3	1	2	1
6x44	7x45	Shared	7.25	4.88417	3	1	2	2
6x48	6x52	s1p_off	7.02	0	3	1	1	2
6x48	7x41	Shared	10.37	3.67594	3	1	1	2
6x48	7x45	Shared	4.52	11.4766	3	1	1	2
6x51	6x55	Shared	4.15	4.04865	0	0	1	2
6x58	7x31	Shared	12.21	6.85656	1	1	2	2
E3	E3	Shared	9.07	8.47812	1	1	2	2
7x31	E3	Shared	6.35	3.8151	1	1	2	2
7x33	7x36	Shared	9.26	5.97875	1	0	2	2
7x35	Lig	s1p_off	4.52	0	0	0	1	0
7x38	Lig	Shared	19.81	6.66594	0	0	1	0
2x64	E1x47	Shared	3.71	0.947292	0	0	1	2
7x33	NT	s1p_off	2.48	0	1	0	2	1
7x32	E3	s1p_off	2.48	0	0	0	2	2
4x63	E2	Shared	1.7	1.60104	0	0	2	1
2x56	3x32	Shared	1.61	1.23323	0	0	2	1
1x31	1x32	s1p_off	1.55	0	1	0	2	2
5x37	E2	Shared	1.53	3.42427	0	0	2	1
3x30	E2	s1p_off	1.45	0	0	0	2	1
2x57	7x38	s1p_on	0	6.36479	0	2	2	1
2x63	3x28	s1p_on	0	6.3525	0	0	2	1
3x21	3x22	s1p_on	0	3.63938	1	0	2	2
3x25	3x26	s1p_on	0	5.28354	1	1	2	2
3x37	Lig	s1p_on	0	6.13615	0	0	1	0
3x40	6x48	s1p_on	0	4.08438	0	1	1	1
4x59	E2	s1p_on	0	4.20062	1	1	2	1
E2	Lig	s1p_on	0	3.95656	1	1	1	0
5x47	6x48	s1p_on	0	7.54646	0	1	1	1
5x47	Lig	s1p_on	0	4.48365	0	1	1	0
6x51	Lig	s1p_on	0	3.39854	0	0	1	0
7x35	7x36	s1p_on	0	4.46771	0	0	1	2
1x39	2x57	s1p_on	0	3.22865	0	2	2	2
2x60	3x32	s1p_on	0	3.74365	1	0	1	1
E1x50	E1x501	s1p_on	0	3.00125	1	0	2	2
3x40	Lig	s1p_on	0	3.18271	0	1	1	0
5x38	E2	s1p_on	0	5.57292	0	1	2	1
5x43	Lig	s1p_on	0	4.72271	1	1	1	0
6x48	Lig	s1p_on	0	3.52781	3	1	1	0
1x32	7x35	s1p_on	0	4.5125	0	0	2	1
7x34	E2	s1p_on	0	2.13698	0	0	2	1
7x32	NT	s1p_on	0	1.74219	0	0	2	1
1x39	7x35	s1p_on	0	1.43802	0	2	2	1
3x30	3x33	s1p_on	0	1.2426	0	0	2	1
3x33	4x57	s1p_on	0	1.2426	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	s1p_off	s1p1_off
	s1p_on	s1p3_on s1p5_on s1p1_on s1p2_on

Network Difference
Value	s1p_off	s1p_on
I_min	3.73	2.91979
Number of Linked Nodes	220	259
Number of Specific Nodes	3 (1.36%)	42 (16.22%)
Number of Shared Nodes	217 (98.64%)	217 (83.78%)
Number of Links	240	290
Number of Specific Links	101 (42.08%)	151 (52.07%)
Number of Shared Links	139 (57.92%)	139 (47.93%)
Number of Hubs	30	34
Number of Specific Hubs	9 (30.00%)	13 (38.24%)
Number of Shared Hubs	21 (70.00%)	21 (61.76%)
Average % Shared Neighbours (Jaccard)	33.88
Average % Shared Neighbours (Otsuka)	42.86
Average % Shared Neighbours (Overlap Coefficient)	52.09
Average % Shared Cliques (k3-6)	56.45
Graphlets Similarity	0.585993

Paths Difference
Value	s1p_off	s1p_on
Number Of Nodes in MetaPath	50	53
Specific Nodes in MetaPath	29 (58.00%)	32 (60.38%)
Shared Nodes in MetaPath	217 (98.64%)	217 (98.64%)
Number Of Links MetaPath	54	53
Specific Links in MetaPath	48 (88.89%)	47 (88.68%)
Shared Links in MetaPath	139 (57.92%)	139 (57.92%)
Number of Shortest Paths	40265	40122
Length Of Smallest Path	3	3
Average Path Length	12.828	11.9449
Length of Longest Path	24	32
Minimum Path Strength	1.235	0.387292
Average Path Strength	8.59213	4.58143
Maximum Path Strength	64.585	37.5409
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.922702	0.910046
Maximum Path Correlation	0.99	0.987604
Minimum % Of Corr. Nodes	5.88235	3.57143
Average % Of Corr. Nodes	52.6273	44.3526
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	43.6568	44.6616
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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