Orange: nodes, hubs and links specific of s1p_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner s1p_on_gp Avg Int. Strength s1p_off Avg Int. Strength s1p_on_gp Num Of Links s1p_off Num Of Links ConSurf
1G.HN.11 s1p_on_gp00502
2G.S1.01 s1p_on_gp00406
3G.S1.02 s1p_on_gp95.23810505
4G.S1.06 s1p_on_gp33.33330408
5G.H1.01 s1p_on_gp19.04760409
6G.H1.07 s1p_on_gp55.55560409
7G.S2.05 s1p_on_gp44.44440403
8G.S2.06 s1p_on_gp00409
9G.S2.08 s1p_on_gp85.71430405
10G.S3.03 s1p_on_gp1000407
11G.S3.04 s1p_on_gp68.2540506
12G.S3.05 s1p_on_gp52.3810607
13G.S3.06 s1p_on_gp1000605
14G.S3.07 s1p_on_gp00409
15G.s3h2.03 s1p_on_gp74.60320509
16G.H2.04 s1p_on_gp52.3810409
17G.H2.06 s1p_on_gp85.71430609
18G.H2.07 s1p_on_gp88.88890609
19G.H2.09 s1p_on_gp00408
20G.S4.03 s1p_on_gp33.33330407
21G.S4.06 s1p_on_gp11.11110407
22G.s4h3.04 s1p_on_gp1000608
23G.s4h3.05 s1p_on_gp30.15870409
24G.H3.01 s1p_on_gp4.76190409
25G.H3.09 s1p_on_gp1000609
26G.H3.13 s1p_on_gp44.44440505
27G.H3.17 s1p_on_gp1000505
28G.H3.18 s1p_on_gp57.14290409
29G.S5.03 s1p_on_gp61.90480508
30G.S5.05 s1p_on_gp88.88890609
31G.S5.06 s1p_on_gp11.11110408
32G.S5.07 s1p_on_gp38.09520409
33G.HG.03 s1p_on_gp33.33330406
34G.HG.04 s1p_on_gp66.66670509
35G.hgh4.01 s1p_on_gp74.60320406
36G.hgh4.02 s1p_on_gp1000607
37G.hgh4.05 s1p_on_gp41.26980407
38G.H4.03 s1p_on_gp61.90480404
39G.H4.05 s1p_on_gp4.76190404
40G.H4.10 s1p_on_gp14.28570406
41G.H4.15 s1p_on_gp95.23810408
42G.h4s6.02 s1p_on_gp69.84130408
43G.h4s6.11 s1p_on_gp33.33330407
44G.h4s6.12 s1p_on_gp22.22220404
45G.S6.02 s1p_on_gp1000607
46G.H5.03 s1p_on_gp63.49210508
47G.H5.08 s1p_on_gp61.90480408
48G.H5.13 s1p_on_gp47.6190508
49G.H5.20 s1p_on_gp60.31750409
50G.H5.26 s1p_on_gp00405
51b.1x1 s1p_on_gp33.33330504
52b.1x11 s1p_on_gp00408
53b.lhb1x3 s1p_on_gp11.11110402
54b.b1x4 s1p_on_gp00407
55b.b1x6 s1p_on_gp52.3810409
56b.l1x3 s1p_on_gp1000609
57b.b2x1 s1p_on_gp1000508
58b.b2x5 s1p_on_gp1000607
59b.l3x2 s1p_on_gp14.28570409
60b.b4x2 s1p_on_gp00408
61b.b4x6 s1p_on_gp1000709
62b.b5x3 s1p_on_gp1000709
63b.b5x5 s1p_on_gp00405
64b.b5x7 s1p_on_gp73.01590407
65b.l5x1 s1p_on_gp85.71430408
66b.l5x5 s1p_on_gp1000709
67b.b6x5 s1p_on_gp66.66670406
68b.b7x1 s1p_on_gp1000504
69b.b7x4 s1p_on_gp22.22220408
70b.l7x2 s1p_on_gp31.7460409
71b.l7x4 s1p_on_gp00409
72b.b8x4 s1p_on_gp1000406
73b.l8x5 s1p_on_gp00503
74b.l9x3 s1p_on_gp1000609
75b.l9x6 s1p_on_gp1000908
76b.b10x5 s1p_on_gp1000609
77b.l10x1 s1p_on_gp00403
78b.b11x4 s1p_on_gp1000409
79b.l11x2 s1p_on_gp1000409
80b.b12x6 s1p_on_gp1000708
81b.b13x7 s1p_on_gp1000507
82b.l13x3 s1p_on_gp1000609
83b.b14x3 s1p_on_gp69.84130405
84b.b15x1 s1p_on_gp88.88890609
85b.b15x2 s1p_on_gp42.85710406
86b.l15x2 s1p_on_gp42.85710409
87b.b16x4 s1p_on_gp95.23810406
88b.b16x5 s1p_on_gp80.95240505
89b.b16x6 s1p_on_gp1000608
90b.b17x5 s1p_on_gp47.6190407
91b.b17x7 s1p_on_gp84.1270408
92b.l17x3 s1p_on_gp1000609
93b.l17x6 s1p_on_gp90.47620509
94b.b18x3 s1p_on_gp57.14290408
95b.l18x1 s1p_on_gp1000706
96b.l18x2 s1p_on_gp90.47620407
97b.b19x2 s1p_on_gp1000706
98b.b19x4 s1p_on_gp88.88890508
99b.l19x2 s1p_on_gp84.1270509
100b.b20x4 s1p_on_gp1000608
101b.b20x6 s1p_on_gp1000506
102b.b20x7 s1p_on_gp4.76190409
103b.l20x2 s1p_on_gp53.96830409
104b.b21x1 s1p_on_gp90.47620507
105b.b21x2 s1p_on_gp22.22220406
106b.b21x5 s1p_on_gp14.28570404
107b.b21x7 s1p_on_gp88.88890605
108b.b22x5 s1p_on_gp79.36510507
109b.l22x5 s1p_on_gp90.47620409
110b.b23x6 s1p_on_gp1000607
111b.l23x1 s1p_on_gp20.63490406
112b.b24x4 s1p_on_gp55.55560406
113b.b24x6 s1p_on_gp55.55560408
114b.l24x3 s1p_on_gp69.84130505
115b.b25x3 s1p_on_gp33.33330505
116b.l25x3 s1p_on_gp95.23810509
117b.b26x3 s1p_on_gp00406
118b.l27x1 s1p_on_gp1000609
119b.l27x2 s1p_on_gp61.90480409
120b.b28x3 s1p_on_gp55.55560407
121b.b28x4 s1p_on_gp61.90480406
122b.b28x6 s1p_on_gp1000609
123g.h1x1 s1p_on_gp33.33330502
124g.h1x11 s1p_on_gp00409
125g.l1x2 s1p_on_gp00402
126g.l1x4 s1p_on_gp44.44440408
127g.h2x11 s1p_on_gp46.03170406
128g.ctx3 s1p_on_gp1000609
129g.ctx6 s1p_on_gp9.523810406
130g.ctx16 s1p_on_gp1000508
1311x39 s1p_on_gp28.57140426
1321x57 s1p_on_gp00427
133I1x49 s1p_on_gp00426
1342x38 s1p_on_gp00437
1352x46 s1p_on_gp58.730250429
1362x50 s1p_on_gp50.793750439
1373x32 s1p_on_gp00426
1383x33 s1p_on_gp15.8730535
1393x43 s1p_on_gp44.44440429
1403x44 s1p_on_gp00417
1413x49 s1p_on_gp47.6190439
1423x50 s1p_on_gp10050639
1433x56 s1p_on_gp33.33330416
1444x41 s1p_on_gp00415
1455x58 s1p_on_gp66.666750639
1466x33 s1p_on_gp44.444450428
1476x52 s1p_on_gp65.079450436
1487x31 s1p_on_gp57.142950423
1497x45 s1p_on_gp47.6190439
1506x26 s1p_on_gp33.33330420
151Lig Shared10010016120
152NT Shared10010010166
1531x50 Shared65.079450449
1542x39 Shared41.2698100448
1552x40 Shared44.4444100549
1562x42 Shared66.66670558
1572x57 Shared66.6667100676
1583x25 Shared100100559
1593x28 Shared100100686
1603x29 Shared41.2698100455
1614x50 Shared22.22220459
162E2 Shared10010019214
1635x39 Shared100100657
1645x62 Shared36.507950456
1656x44 Shared19.0476100459
1666x48 Shared100100768
167E3 Shared88.8889100752
1687x53 Shared66.6667100449
1691x60 s1p_off050266
170I1x50 s1p_off33.3333100358
1712x47 s1p_off050249
1722x60 s1p_off11.1111100355
1732x61 s1p_off4.76190345
1743x37 s1p_off00246
1754x59 s1p_off00345
1765x47 s1p_off0100347
1776x34 s1p_off050248
1786x55 s1p_off00346
1797x49 s1p_off33.333350349
1808x47 s1p_off050248
   
Orange: nodes, hubs and links specific of s1p_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner s1p_on_gp Recurrence s1p_off Recurrence s1p_on_gp Hub1? s1p_off Hub1? s1p_on_gp Hub2? s1p_off Hub2? ConSurf1 ConSurf2
1b.l2x5 b.l4x2 s1p_on_gp11.62610NoNoNoNo54
2b.l4x2 g.ctx15 s1p_on_gp25.54220NoNoNoNo49
3b.l26x5 g.ctx15 s1p_on_gp26.10360NoNoNoNo59
4b.l26x5 g.ctx4 s1p_on_gp53.79140NoNoNoNo57
5g.ctx3 g.ctx4 s1p_on_gp54.34930YesNoNoNo97
6g.ctx3 g.ctx6 s1p_on_gp57.70350YesNoYesNo96
7b.l22x5 g.ctx6 s1p_on_gp59.99820YesNoYesNo96
8b.l22x5 b.lhb1x3 s1p_on_gp31.22330YesNoYesNo92
9b.h2x5 b.lhb1x3 s1p_on_gp35.11960NoNoYesNo52
10b.h2x1 b.h2x5 s1p_on_gp66.73650NoNoNoNo55
11b.b21x5 b.h2x1 s1p_on_gp67.41120YesNoNoNo45
12b.b21x5 b.b21x7 s1p_on_gp68.220YesNoYesNo45
13b.b21x7 b.b24x6 s1p_on_gp80.03580YesNoYesNo58
14b.b23x6 b.b24x6 s1p_on_gp79.10310YesNoYesNo78
15b.b23x6 b.l23x2 s1p_on_gp81.73930YesNoNoNo78
16b.l21x7 b.l23x2 s1p_on_gp82.69130NoNoNoNo58
17b.l21x7 b.l23x1 s1p_on_gp82.87870NoNoYesNo56
18b.b22x1 b.l23x1 s1p_on_gp1000NoNoYesNo86
19b.b22x1 b.b22x2 s1p_on_gp99.82460NoNoNoNo88
20b.b22x2 b.b26x3 s1p_on_gp99.64860NoNoYesNo86
21b.b26x3 b.b27x3 s1p_on_gp97.46020YesNoNoNo68
22b.b27x3 b.l25x3 s1p_on_gp94.75110NoNoYesNo89
23b.l25x3 b.l27x2 s1p_on_gp94.3760YesNoYesNo99
24b.l25x4 b.l27x2 s1p_on_gp94.07960NoNoYesNo59
25I1x49 b.l25x4 s1p_on_gp93.68140YesNoNoNo65
268x49 I1x49 s1p_on_gp92.44590.489734NoNoYesNo76
272x40 8x49 s1p_on_gp92.25110YesYesNoNo97
282x37 2x39 s1p_on_gp88.60760NoNoYesYes78
292x39 3x49 s1p_on_gp10.83780YesYesYesNo89
30b.l22x5 b.l24x2 s1p_on_gp30.86840YesNoNoNo96
31b.h2x5 b.l24x2 s1p_on_gp31.40430NoNoNoNo56
32G.HN.47 b.b5x3 s1p_on_gp13.48390NoNoYesNo69
33G.HN.47 b.b4x2 s1p_on_gp13.29940NoNoYesNo68
34b.l23x1 b.l25x6 s1p_on_gp83.60590YesNoNoNo68
35b.l25x6 b.l27x1 s1p_on_gp80.99430NoNoYesNo89
36b.b2x1 b.l27x1 s1p_on_gp80.53660YesNoYesNo89
37b.b2x1 b.l3x1 s1p_on_gp83.47440YesNoNoNo89
38b.l3x1 b.l5x5 s1p_on_gp83.53650NoNoYesNo99
39G.S3.06 b.l5x5 s1p_on_gp54.90250YesNoYesNo59
40G.S1.03 G.S3.06 s1p_on_gp51.08590NoNoYesNo95
41G.S1.03 I2x53 s1p_on_gp51.06890NoNoNoNo97
42I2x52 I2x53 s1p_on_gp50.31280NoNoNoNo47
43G.S1.02 I2x52 s1p_on_gp47.64790YesNoNoNo54
44G.S1.02 G.S3.03 s1p_on_gp40.63820YesNoYesNo57
45G.S2.06 G.S3.03 s1p_on_gp40.38460YesNoYesNo97
46G.S2.06 G.S3.05 s1p_on_gp38.77250YesNoYesNo97
47G.S1.04 G.S3.05 s1p_on_gp15.58380NoNoYesNo77
48G.S1.04 G.S4.03 s1p_on_gp15.17120NoNoYesNo77
49G.S1.06 G.S3.05 s1p_on_gp21.52440YesNoYesNo87
50G.S1.06 G.S4.03 s1p_on_gp15.2330YesNoYesNo87
51G.H2.04 G.H2.07 s1p_on_gp72.95580YesNoYesNo99
52G.H2.07 b.l7x2 s1p_on_gp40.01940YesNoYesNo99
53b.l5x5 b.l7x2 s1p_on_gp86.40750YesNoYesNo99
54b.l7x2 b.l9x6 s1p_on_gp45.02520YesNoYesNo98
55b.l17x5 b.l17x6 s1p_on_gp73.70460NoNoYesNo69
56b.l17x5 b.l19x2 s1p_on_gp74.80190NoNoYesNo69
57b.l17x3 b.l19x2 s1p_on_gp64.39550YesNoYesNo99
58b.b19x4 b.l17x3 s1p_on_gp54.10040YesNoYesNo89
59b.b18x3 b.b19x4 s1p_on_gp15.35510YesNoYesNo88
60b.b15x2 b.b18x3 s1p_on_gp15.07930YesNoYesNo68
61b.b15x2 b.b18x5 s1p_on_gp23.7140YesNoNoNo65
62b.b18x5 b.l14x1 s1p_on_gp21.91480NoNoNoNo54
63b.l14x1 b.l14x3 s1p_on_gp20.13140NoNoNoNo45
64b.l14x3 b.l14x5 s1p_on_gp19.5390NoNoNoNo55
65b.l14x5 b.l16x2 s1p_on_gp18.94740NoNoNoNo59
66b.l16x1 b.l16x2 s1p_on_gp18.35940NoNoNoNo49
67b.b15x1 b.l16x1 s1p_on_gp14.66260YesNoNoNo94
68b.b14x3 b.b15x1 s1p_on_gp16.28810YesNoYesNo59
69b.b10x2 b.b14x3 s1p_on_gp15.65150NoNoYesNo65
70b.b10x2 b.b10x4 s1p_on_gp15.28220NoNoNoNo66
71b.b10x4 b.b2x4 s1p_on_gp14.91320NoNoNoNo66
72b.b2x4 b.b6x5 s1p_on_gp14.56210NoNoYesNo66
73b.b3x3 b.b6x5 s1p_on_gp13.47010NoNoYesNo86
74b.b3x3 b.b4x3 s1p_on_gp11.39650NoNoNoNo87
75b.b4x3 b.b5x7 s1p_on_gp10.70220NoNoYesNo77
76b.b5x7 b.b5x8 s1p_on_gp14.32840YesNoNoNo75
77b.b4x2 b.b5x8 s1p_on_gp14.33020YesNoNoNo85
78b.b19x2 b.b19x4 s1p_on_gp29.56960YesNoYesNo68
79b.b15x2 b.b19x2 s1p_on_gp15.58060YesNoYesNo66
80G.H2.04 G.H3.08 s1p_on_gp71.85830YesNoNoNo99
81G.H2.06 b.l9x6 s1p_on_gp74.19540YesNoYesNo98
82G.H2.06 b.l17x6 s1p_on_gp72.6920YesNoYesNo99
83G.S4.03 G.S5.03 s1p_on_gp21.05210YesNoYesNo78
84G.H3.08 G.S4.04 s1p_on_gp71.49810NoNoNoNo99
85G.S4.04 G.S4.06 s1p_on_gp50.60880NoNoYesNo97
86G.H3.09 G.S4.04 s1p_on_gp20.61890YesNoNoNo99
87G.S4.06 G.S5.06 s1p_on_gp20.22160YesNoYesNo78
88G.H4.15 G.S4.06 s1p_on_gp28.40470YesNoYesNo87
89G.S5.06 G.s4h3.01 s1p_on_gp18.92080YesNoNoNo87
90G.HG.04 G.s4h3.01 s1p_on_gp18.53770YesNoNoNo97
91G.HG.04 G.s4h3.04 s1p_on_gp10.29040YesNoYesNo98
92G.HG.07 G.s4h3.04 s1p_on_gp14.21540NoNoYesNo98
93G.HG.07 G.s4h3.06 s1p_on_gp13.35770NoNoNoNo98
94G.H3.02 G.H4.15 s1p_on_gp11.63690NoNoYesNo88
95G.H3.02 G.hgh4.01 s1p_on_gp11.20850NoNoYesNo86
96G.hgh4.01 G.s4h3.04 s1p_on_gp10.22460YesNoYesNo68
97G.H3.01 G.s4h3.06 s1p_on_gp10.68960YesNoNoNo98
98G.H3.06 G.hgh4.02 s1p_on_gp15.85850NoNoYesNo67
99G.H5.10 G.S5.03 s1p_on_gp18.61970NoNoYesNo68
100G.H5.10 G.S6.02 s1p_on_gp17.76870NoNoYesNo67
101G.H4.10 G.hgh4.02 s1p_on_gp10.47550YesNoYesNo67
102b.b16x6 b.b17x3 s1p_on_gp10.84070YesNoNoNo85
103b.b17x3 g.h1x10 s1p_on_gp15.39380NoNoNoNo59
104g.h1x10 g.h1x13 s1p_on_gp16.93030NoNoNoNo91
105b.b17x2 g.h1x13 s1p_on_gp17.42610NoNoNoNo31
106b.b17x2 b.b17x4 s1p_on_gp18.34120NoNoNoNo35
107b.b16x5 b.b17x4 s1p_on_gp19.86810YesNoNoNo55
108b.b16x5 b.b17x5 s1p_on_gp11.61140YesNoYesNo57
109b.1x19 b.b21x1 s1p_on_gp30.89450NoNoYesNo67
110b.1x15 b.1x19 s1p_on_gp28.07180NoNoNoNo76
111b.1x15 g.h1x15 s1p_on_gp26.64970NoNoNoNo78
112b.1x11 g.h1x15 s1p_on_gp25.22530YesNoNoNo88
113b.1x11 g.h1x12 s1p_on_gp13.7460YesNoNoNo86
114g.h1x12 g.h1x9 s1p_on_gp13.02350NoNoNoNo66
115g.h1x5 g.h1x9 s1p_on_gp11.57690NoNoNoNo66
116g.h1x1 g.h1x5 s1p_on_gp10.12790YesNoNoNo26
117b.b20x5 b.b21x7 s1p_on_gp25.16650NoNoYesNo75
118b.b20x5 b.b21x4 s1p_on_gp24.92310NoNoNoNo75
119b.b20x7 b.b21x4 s1p_on_gp24.70850YesNoNoNo95
120b.b20x7 b.l20x2 s1p_on_gp25.80050YesNoYesNo99
121b.l20x2 g.l1x5 s1p_on_gp31.68450YesNoNoNo94
122g.l1x3 g.l1x5 s1p_on_gp32.49130NoNoNoNo14
123g.l1x2 g.l1x3 s1p_on_gp33.30370YesNoNoNo21
124b.b21x1 g.l1x2 s1p_on_gp15.57390YesNoYesNo72
125b.l4x2 g.ctx16 s1p_on_gp13.59130NoNoYesNo48
126b.b4x6 b.b5x3 s1p_on_gp15.00460YesNoYesNo99
127b.b3x2 b.b4x6 s1p_on_gp19.99870NoNoYesNo59
128b.b2x5 b.b3x2 s1p_on_gp20.34660YesNoNoNo75
129b.b2x5 b.l26x1 s1p_on_gp24.37820YesNoNoNo77
130b.l26x1 b.l26x3 s1p_on_gp24.79190NoNoNoNo77
131b.l26x3 b.l26x5 s1p_on_gp27.17770NoNoNoNo75
132b.l11x1 b.l9x6 s1p_on_gp24.20920NoNoYesNo98
133b.b11x6 b.l11x1 s1p_on_gp23.79310NoNoNoNo99
134b.b11x6 b.l9x3 s1p_on_gp20.47460NoNoYesNo99
135b.b12x6 b.l9x3 s1p_on_gp16.26850YesNoYesNo89
136b.b11x2 b.b12x6 s1p_on_gp13.96970NoNoYesNo78
137b.b10x5 b.b11x2 s1p_on_gp13.49620YesNoNoNo97
138b.b10x5 b.b8x3 s1p_on_gp11.11980YesNoNoNo96
139b.b17x7 b.b19x2 s1p_on_gp10.49920YesNoYesNo86
140b.b20x4 b.b20x6 s1p_on_gp20.01130YesNoYesNo86
141b.b20x2 b.b20x4 s1p_on_gp10.78070NoNoYesNo68
1423x50 7x53 s1p_on_gp66.7810YesNoYesYes99
1433x43 7x53 s1p_on_gp66.61520YesNoYesYes99
1443x43 6x44 s1p_on_gp49.73264.09368YesNoYesYes99
1456x44 6x48 s1p_on_gp47.92823.50035YesYesYesYes98
1462x46 2x50 s1p_on_gp14.20780YesNoYesNo99
1472x46 3x43 s1p_on_gp16.58010YesNoYesNo99
1481x39 2x57 s1p_on_gp12.61820YesNoYesYes66
149b.b17x5 g.l1x2 s1p_on_gp17.58340YesNoYesNo72
150b.b15x2 b.b16x5 s1p_on_gp11.07060YesNoYesNo65
151b.b17x7 b.b21x1 s1p_on_gp31.3390YesNoYesNo87
152b.b19x4 b.b20x6 s1p_on_gp10.0020YesNoYesNo86
153b.b20x4 b.l17x3 s1p_on_gp10.7780YesNoYesNo89
154b.b20x2 b.l19x2 s1p_on_gp10.8650NoNoYesNo69
155G.H2.07 b.l9x6 s1p_on_gp33.61030YesNoYesNo98
156b.b17x7 b.b20x6 s1p_on_gp29.40950YesNoYesNo86
1572x37 2x40 Shared88.820520.6724NoNoYesYes79
1582x39 3x50 Shared77.881736.9216YesYesYesNo89
1596x48 Lig Shared43.158191.3135YesYesYesYes80
160E2 Lig Shared10.628737.8226YesYesYesYes40
1612x57 2x61 s1p_off5.2869510.3692YesYesNoYes65
1622x57 Lig s1p_off019.7369YesYesYesYes60
1632x50 7x49 s1p_off014.3185YesNoNoYes99
1642x46 7x49 s1p_off0.64659394.3178YesNoNoYes99
1652x46 3x42 s1p_off2.8566794.682YesNoNoNo98
1662x45 3x42 s1p_off2.4528495.0399NoNoNoNo98
1672x45 4x50 s1p_off1.4811995.8247NoNoYesYes99
1683x38 4x50 s1p_off0.57074797.7648NoNoYesYes79
1693x38 4x53 s1p_off0.33793998.0662NoNoNoNo78
1703x37 4x53 s1p_off2.896298.3613NoYesNoNo68
1713x37 5x47 s1p_off0100NoYesNoYes67
1723x36 5x47 s1p_off046.0507NoNoNoYes67
1733x36 6x48 s1p_off1.3965645.9346NoNoYesYes68
1747x49 7x53 s1p_off084.4384NoYesYesYes99
1755x47 6x52 s1p_off3.1858246.7948NoYesYesNo76
1766x48 6x52 s1p_off046.5624YesYesYesNo86
1771x56 1x60 s1p_off010.702NoNoNoYes86
1781x60 I1x50 s1p_off0.650418.5565NoYesNoYes68
1798x50 I1x50 s1p_off054.282NoNoNoYes88
1807x53 8x50 s1p_off082.0619YesYesNoNo98
1812x40 I1x50 s1p_off0.26092239.0971YesYesNoYes98
1822x37 2x38 s1p_off018.8987NoNoYesNo77
1832x38 4x42 s1p_off1.6782710.0333YesNoNoNo77
1842x39 2x40 s1p_off021.6676YesYesYesYes89
1852x39 6x33 s1p_off019.7118YesYesYesNo88
1866x33 8x47 s1p_off020.2832YesNoNoYes88
1878x47 8x50 s1p_off0.77105129.4217NoYesNoNo88
188Lig NT s1p_off5.7054319.3382YesYesYesYes06
1893x50 6x34 s1p_off033.6849YesNoNoYes98
1905x61 6x34 s1p_off013.0847NoNoNoYes98
1915x62 6x34 s1p_off0.77866517.5425YesYesNoYes68

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
LigNTShared12.726.778891201
2x57Ligs1p_off6.3401010
2x60LigShared10.3859.003811210
3x28Ligs1p_off3.9401210
3x29LigShared14.2857.779051210
3x32LigShared11.4453.510481210
3x33LigShared7.88511.76031210
6x48LigShared3.433.013021210
7x35Ligs1p_off6.13501010
7x38LigShared18.946.566191010
7x42Ligs1p_off4.11501010
NTNTShared59.83530.64871211
E2NTShared83.2969.37891211
3x21NTs1p_off6.12501021
3x22NTShared9.4956.50461221
E1x50NTShared5.7552.795241221
E1x501NTShared19.44515.70220221
3x25NTShared11.724.055711221
E3NTShared12.1156.430321221
2x572x60s1p_off4.6501011
2x572x61Shared5.2757.402061012
2x573x32Shared4.894.332381011
2x577x42Shared13.0554.986511011
2x602x64s1p_off5.21501211
2x603x28Shared6.636.851431211
2x603x29s1p_off7.8901211
2x63E1x52s1p_off4.1501022
2x633x28Shared3.647.016191021
2x643x28Shared6.5852.929051011
3x28E1x50Shared9.74.413971212
3x28E1x52s1p_off5.46501212
3x213x22Shared3.533.956191022
3x253x26Shared6.5154.025561222
3x253x28Shared97.619051221
3x253x29Shared7.6310.76571221
3x25E2Shared28.3117.79671221
3x26E2Shared24.8315.90271221
3x283x29Shared12.793.120791211
3x29E2Shared6.0212.78221211
3x33E2Shared14.9053.573171211
3x335x39Shared5.6757.760161212
3x365x47s1p_off7.3100211
3x366x48Shared16.515.096510211
3x373x41s1p_off4.11500012
3x374x53Shared6.462.586670012
3x374x56s1p_off5.18500012
3x375x47s1p_off5.88500011
3x405x47s1p_off6.5500211
3x405x50Shared3.7952.834130212
3x406x44s1p_off3.27500212
4x59E2Shared4.564.120951221
4x595x39Shared4.15.040951222
4x60E2Shared11.8258.929841221
4x605x39Shared12.5214.10861222
5x36E2Shared9.9956.606031221
5x39E2Shared20.4259.915561221
5x42E2s1p_off6.01501021
E2E2Shared51.0242.02031211
5x40E2Shared8.492.511221
6x58E2Shared21.88512.66921221
7x31E2Shared8.1056.693331221
7x32E2s1p_off3.3300021
6x55E2s1p_off3.6701211
5x365x38Shared5.976.304291222
5x395x43Shared9.414.352221221
5x406x55Shared5.8352.621111221
5x476x52Shared6.96514.51190212
6x446x48Shared13.536.905711221
6x447x45Shared7.255.446511222
6x486x52s1p_off10.52501212
6x487x41Shared9.0751.852381212
6x487x45Shared6.21512.64521212
6x516x55Shared3.465.143020211
6x517x38s1p_off3.4600211
6x587x31Shared9.56.935711222
E3E3Shared13.873.844291222
7x337x35s1p_off5.23500021
7x337x36Shared3.65.30190022
7x357x38s1p_off5.3301011
E2LigShared3.313.738251210
E1x51NTs1p_off3.79501021
E1x48NTs1p_off5.56500021
5x446x55s1p_off2.96500021
E1x47NTs1p_off2.89500021
1x392x61s1p_off2.85500022
2x532x57s1p_off2.6700021
7x34E2Shared2.5451.648890021
2x542x57s1p_off2.17500021
4x63E2Shared1.71.37460021
3x23NTs1p_off1.69500021
1x432x61s1p_off1.61500022
1x36NTs1p_off1.57500021
1x33NTs1p_off1.54501021
3x30E2s1p_off1.4501021
2x64Ligs1p_on_gp04.223971010
3x36Ligs1p_on_gp08.788730210
3x37Ligs1p_on_gp06.001430010
5x47Ligs1p_on_gp04.975240210
6x51Ligs1p_on_gp04.992060210
6x55Ligs1p_on_gp04.044921210
1x362x61s1p_on_gp02.450160022
1x392x57s1p_on_gp04.274440021
1x432x57s1p_on_gp03.049680021
2x577x38s1p_on_gp07.851751011
2x603x32s1p_on_gp03.628251211
E1x50E1x501s1p_on_gp03.59811222
3x335x43s1p_on_gp02.461591211
3x406x48s1p_on_gp03.775710211
3x415x50s1p_on_gp04.076350022
4x565x39s1p_on_gp02.491750022
4x594x60s1p_on_gp02.761431222
5x38E2s1p_on_gp06.850320221
5x37E2s1p_on_gp04.620160021
5x446x52s1p_on_gp03.940790022
5x476x48s1p_on_gp06.489210211
7x31E3s1p_on_gp04.386981222
3x40Ligs1p_on_gp03.710160210
7x357x36s1p_on_gp03.915871012
5x43Ligs1p_on_gp05.141590210
7x427x46s1p_on_gp02.864291012
3x213x23s1p_on_gp02.276671022
7x32NTs1p_on_gp02.056190021
1x397x35s1p_on_gp01.986350021
2x532x54s1p_on_gp01.857140022
4x565x42s1p_on_gp01.703650022
2x563x32s1p_on_gp01.462220021
2x533x36s1p_on_gp01.429520021
E1x47E1x48s1p_on_gp01.353330022
3x303x33s1p_on_gp01.126511021
2x64E1x47s1p_on_gp01.119841012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
s1p_on_gp s1p1_on_gp
s1p3_on_gp
s1p5_on_gp
s1p_off s1p1_off
s1p5_off
Network Difference
Value s1p_on_gp s1p_off
Imin 2.43714 3.255
Number of Linked Nodes 884 232
Number of Specific Nodes 654 (73.98%) 2  (0.86%)
Number of Shared Nodes 230 (26.02%) 230  (99.14%)
Number of Links 1084 266
Number of Specific Links 940 (86.72%) 122  (45.86%)
Number of Shared Links 144 (13.28%) 144  (54.14%)
Number of Hubs 168 30
Number of Specific Hubs 150 (89.29%) 12  (40.00%)
Number of Shared Hubs 18 (10.71%) 18  (60.00%)
Average % Shared Neighbours (Jaccard) 9.92
Average % Shared Neighbours (Otsuka) 12.42
Average % Shared Neighbours (Overlap Coefficient) 14.66
Average % Shared Cliques (k3-6) 52.19
Graphlets Similarity 0.611337
Paths Difference
Value s1p_on_gp s1p_off
Number Of Nodes in MetaPath 152 34
Specific Nodes in MetaPath 141 (92.76%) 23  (67.65%)
Shared Nodes in MetaPath 230 (26.02%) 230  (26.02%)
Number Of Links MetaPath 160 35
Specific Links in MetaPath 156 (97.50%) 31  (88.57%)
Shared Links in MetaPath 144 (13.28%) 144  (13.28%)
Number of Shortest Paths 924678 46776
Length Of Smallest Path 3 3
Average Path Length 27.6802 16.3156
Length of Longest Path 61 31
Minimum Path Strength 0.2 0.6975
Average Path Strength 4.99757 6.36826
Maximum Path Strength 42.6408 51.8575
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.974952 0.904912
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 2 4
Average % Of Corr. Nodes 46.6401 41.8598
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 54.8135 45.9458
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p_off_on_gp.zip<



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