Orange: nodes, hubs and links specific of smo_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of smo_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner smo_off_allo Avg Int. Strength smo_off Avg Int. Strength smo_off_allo Num Of Links smo_off Num Of Links ConSurf
1NT.L56 smo_off_allo6.3780507
2NT.P57 smo_off_allo5.17250407
3NT.Y58 smo_off_allo10.52750409
4NT.S62 smo_off_allo4.480408
5NT.D68 smo_off_allo8.1920506
6NT.S69 smo_off_allo4.5940507
7NT.W82 smo_off_allo5.861250807
8NT.W92 smo_off_allo9.2340509
9NT.I95 smo_off_allo4.4750608
10NT.L98 smo_off_allo4.60750408
11NT.Y103 smo_off_allo6.622860707
12NT.K106 smo_off_allo12.540406
13NT.V112 smo_off_allo3.61250408
14NT.Q117 smo_off_allo5.070406
15NT.L119 smo_off_allo3.6350406
16NT.C120 smo_off_allo7.49750409
17NT.R124 smo_off_allo11.0180506
18NT.W136 smo_off_allo9.055710709
19NT.P137 smo_off_allo6.990509
20NT.F139 smo_off_allo6.896670608
21NT.L140 smo_off_allo6.580507
22NT.C142 smo_off_allo5.81750409
23NT.Y146 smo_off_allo6.3180504
24NT.F147 smo_off_allo7.330408
25NT.I158 smo_off_allo4.45750405
26NT.F160 smo_off_allo9.880408
27NT.N175 smo_off_allo5.660506
28NT.K177 smo_off_allo5.95750404
29NT.S178 smo_off_allo6.780508
30NT.N192 smo_off_allo7.066670607
31NT.P193 smo_off_allo5.2350408
32NT.L194 smo_off_allo4.7380506
33NT.F195 smo_off_allo6.070806
341x44 smo_off_allo4.6683.71515
351x54 smo_off_allo5.1859.98429
361x57 smo_off_allo6.5357.43083439
372x42 smo_off_allo5.76756.81625427
382x46 smo_off_allo8.46612.75538
39E1.Q257 smo_off_allo8.830409
40E1.R263 smo_off_allo11.87750408
41E1.R269 smo_off_allo5.665710707
42E1.D271 smo_off_allo8.630508
43E1.T273 smo_off_allo4.7620508
44E1.R275 smo_off_allo7.9750407
453x34 smo_off_allo4.86255.22333438
463x37 smo_off_allo6.056.79333438
473x38 smo_off_allo4.963.2725419
483x41 smo_off_allo3.464.3625417
493x43 smo_off_allo4.89255.0075428
503x48 smo_off_allo7.297.68917438
513x51 smo_off_allo6.848.94833437
524x52 smo_off_allo3.03252.2025425
534x53 smo_off_allo4.1284.18667539
544x56 smo_off_allo4.527.9125418
55E2.Q353 smo_off_allo8.050407
56E2.D355 smo_off_allo4.4580509
57E2.D357 smo_off_allo9.0780508
58E2.V359 smo_off_allo5.4440507
59E2.Y367 smo_off_allo7.5520505
605x44 smo_off_allo5.70258.33833439
616x53 smo_off_allo5.588.64583438
626x77 smo_off_allo3.82750404
63E3.N484 smo_off_allo9.75250404
64E3.R485 smo_off_allo5.5950407
65E3.P486 smo_off_allo10.8750409
667x37 smo_off_allo4.35758.75427
677x42 smo_off_allo3.6654.835428
687x52 smo_off_allo4.914.1825439
697x53 smo_off_allo3.5064.365529
707x56 smo_off_allo5.897.14438
71Allont2 smo_off_allo8.032860700
721x28 Shared7.88758.535448
731x29 Shared8.95759.80062448
742x39 Shared8.234.95458469
752x43 Shared4.29254.01313448
762x45 Shared5.9758.3865459
772x52 Shared6.426.29437546
782x58 Shared6.1186.455577
793x29 Shared8.50759.47449
803x33 Shared7.324298.04792769
813x42 Shared11.101712.1596669
823x50 Shared7.995.76958567
834x50 Shared8.2227.606559
844x60 Shared10.711.235447
855x41 Shared12.35256.334454
865x461 Shared7.536.4725448
875x61 Shared8.36256.409458
886x36 Shared4.7566.034558
896x54 Shared5.388.08187447
906x61 Shared11.0329.395559
916x65 Shared5.825.60417467
926x72 Shared7.794.69563444
937x46 Shared6.9126.99958569
94Lig Shared8.045457.4811711150
95NT.L79 smo_off7.030.9149
96NT.S89 smo_off01.1075040
97NT.D95 smo_off02.43188040
98NT.Y130 smo_off01.84040
99NT.K133 smo_off02.89125040
100NT.W163 smo_off03.33375040
101NT.F166 smo_off01.6385050
102NT.F187 smo_off02.27562040
103NT.L197 smo_off03.57812040
104NT.R199 smo_off05.0715050
105NT.N202 smo_off06.20312040
106NT.S205 smo_off07.297050
107NT.W206 smo_off06.03437040
108NT.Y207 smo_off08.21375040
109NT.N219 smo_off06.432050
110NT.L221 smo_off04.32187040
111NT.F222 smo_off07.25857070
1121x39 smo_off7.736677.38937345
1132x61 smo_off011.1156040
1142x62 smo_off07.6625040
115E1.R296 smo_off06.07917060
116E1.D298 smo_off07.11417060
117E1.T300 smo_off06.27625040
1183x47 smo_off5.3255.61875248
1193x54 smo_off2.746674.72458368
120E2.D382 smo_off04.44063040
121E2.D384 smo_off07.4015050
122E2.S387 smo_off04.995040
123E2.I389 smo_off05.88813040
124E2x51 smo_off6.653335.41313349
125E2.Y394 smo_off07.9835050
1265x55 smo_off7.7854.58375246
1275x66 smo_off2.282.92937248
1286x30 smo_off2.823.5895258
1296x41 smo_off3.653.949155
1306x48 smo_off5.685.08875346
131E3.N511 smo_off06.55938040
1327x41 smo_off7.973337.38375348
1337x55 smo_off4.819.5485259
1348x54 smo_off4.534.819359
1358x55 smo_off00.790625045
1365x76 smo_off01.31060
1376x19 smo_off00.588125040
   
Orange: nodes, hubs and links specific of smo_off_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of smo_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner smo_off_allo Recurrence smo_off Recurrence smo_off_allo Hub1? smo_off Hub1? smo_off_allo Hub2? smo_off Hub2? ConSurf1 ConSurf2
1NT.K39 NT.L114 smo_off_allo11.66540NoNoNoNo67
2NT.L114 NT.L65 smo_off_allo15.19630NoNoNoNo78
3NT.L65 NT.P115 smo_off_allo15.8960NoNoNoNo89
4NT.A101 NT.P115 smo_off_allo28.14950NoNoNoNo89
5NT.A101 NT.V155 smo_off_allo28.68290NoNoNoNo85
6NT.C100 NT.V155 smo_off_allo29.22410NoNoNoNo95
7NT.C100 NT.C51 smo_off_allo49.4130NoNoNoNo99
8NT.C51 NT.L56 smo_off_allo49.81310NoNoYesNo97
9NT.L46 NT.L56 smo_off_allo790NoNoYesNo77
10NT.L46 NT.T61 smo_off_allo19.23350NoNoNoNo79
11NT.Q72 NT.T61 smo_off_allo18.01350NoNoNoNo89
12NT.K47 NT.Q72 smo_off_allo17.18920NoNoNoNo48
13NT.F147 NT.P115 smo_off_allo16.28190YesNoNoNo89
14NT.E74 NT.S69 smo_off_allo14.87930NoNoYesNo57
15NT.E74 NT.S71 smo_off_allo14.76780NoNoNoNo56
16NT.D73 NT.S71 smo_off_allo15.63250NoNoNoNo46
17NT.D73 NT.K47 smo_off_allo15.90360NoNoNoNo44
186x70 NT.N49 smo_off_allo97.34470NoNoNoNo45
19NT.L46 NT.N49 smo_off_allo96.95660NoNoNoNo75
206x66 6x70 smo_off_allo98.11430.448783NoNoNoNo54
216x66 NT.Y180 smo_off_allo98.30670NoNoNoNo58
22NT.L170 NT.Y180 smo_off_allo99.25230NoNoNoNo98
23NT.I188 NT.L170 smo_off_allo99.62720NoNoNoNo69
246x65 NT.I188 smo_off_allo1000YesYesNoNo76
25E2.Y367 Lig smo_off_allo55.16530YesNoYesYes50
26E2.Y367 E2x51 smo_off_allo70.81530YesNoNoYes59
273x33 E2x51 smo_off_allo69.98670YesYesNoYes99
283x29 3x33 smo_off_allo33.95640.335061YesYesYesYes99
293x29 E2.V354 smo_off_allo30.59490YesYesNoNo98
30E1.E278 E2.V354 smo_off_allo30.07240NoNoNoNo88
31E1.E278 E1.T280 smo_off_allo24.68730NoNoNoNo87
32E1.T280 NT.K177 smo_off_allo10.62460NoNoYesNo74
33NT.N175 NT.P176 smo_off_allo17.10940YesNoNoNo63
34NT.P176 NT.W179 smo_off_allo15.90140NoNoNoNo35
35NT.G185 NT.W179 smo_off_allo14.69130NoNoNoNo85
36NT.G185 NT.S162 smo_off_allo13.47890NoNoNoNo86
37E1.R269 E1.T280 smo_off_allo13.5030YesNoNoNo77
38NT.C100 NT.F160 smo_off_allo21.21540NoNoYesNo98
39NT.F160 NT.R96 smo_off_allo40.85550YesNoNoNo88
40NT.R96 NT.W92 smo_off_allo37.52020NoNoYesNo89
41NT.F160 NT.I158 smo_off_allo21.44610YesNoYesNo85
42NT.L56 NT.P57 smo_off_allo25.07430YesNoYesNo77
43NT.I158 NT.P57 smo_off_allo21.90410YesNoYesNo57
44NT.I95 NT.W82 smo_off_allo21.87790YesNoYesNo87
456x68 6x72 smo_off_allo14.88599.77019NoNoYesYes54
461x29 1x33 smo_off_allo19.90581.78139YesYesNoNo88
471x29 E2.V359 smo_off_allo25.31920YesYesYesNo87
48E2.V359 NT.N192 smo_off_allo17.40570YesNoYesNo77
49NT.N192 NT.P193 smo_off_allo11.19090YesNoYesNo78
50E2.V359 NT.F195 smo_off_allo12.09280YesNoYesNo76
51Lig NT.F195 smo_off_allo10.62570YesYesYesNo06
52E2.D357 E2.V359 smo_off_allo10.5820YesNoYesNo87
53E2.D357 Lig smo_off_allo27.82810YesNoYesYes80
54E3.I482 NT.L194 smo_off_allo14.58310NoNoYesNo46
551x36 7x42 smo_off_allo12.26660NoNoYesNo78
561x32 1x36 smo_off_allo19.87631.68065NoNoNoNo87
571x32 E2.V359 smo_off_allo20.82290NoNoYesNo87
582x58 E2.I362 smo_off_allo27.18420YesYesNoNo79
59E2.I362 E2.S360 smo_off_allo29.06450NoNoNoNo98
60E2.D357 E2.S360 smo_off_allo29.58260YesNoNoNo88
612x58 7x46 smo_off_allo33.79037.73693YesYesYesYes79
621x40 7x46 smo_off_allo22.84861.74171NoNoYesYes79
631x40 2x55 smo_off_allo11.09250NoNoNoNo78
641x43 2x55 smo_off_allo11.16581.18225NoNoNoNo88
651x43 7x46 smo_off_allo23.7213.52997NoNoYesYes89
661x40 2x59 smo_off_allo11.69271.17844NoNoNoNo77
671x43 7x50 smo_off_allo12.46231.77147NoNoNoNo88
681x44 2x55 smo_off_allo21.23290.591508YesNoNoNo58
691x44 2x59 smo_off_allo11.0980YesNoNoNo57
701x44 2x52 smo_off_allo18.86720YesNoYesYes56
711x44 2x56 smo_off_allo11.14830YesNoNoNo56
727x50 7x53 smo_off_allo11.35710NoNoYesNo89
733x42 4x50 smo_off_allo44.4277.18282YesYesYesYes99
743x34 4x57 smo_off_allo54.42190YesNoNoNo89
753x33 4x57 smo_off_allo54.62852.26147YesYesNoNo99
762x46 4x46 smo_off_allo11.84357.60718YesNoNoNo89
774x46 4x50 smo_off_allo12.17487.0752NoNoYesYes99
781x54 2x45 smo_off_allo17.87574.0047YesNoYesYes99
792x39 2x43 smo_off_allo11.81622.81863YesYesYesYes98
802x43 3x42 smo_off_allo29.01533.91082YesYesYesYes89
812x40 2x43 smo_off_allo18.17420NoNoYesYes98
822x40 3x50 smo_off_allo16.63720NoNoYesYes97
833x46 3x50 smo_off_allo16.63720NoNoYesYes87
842x43 3x46 smo_off_allo18.17420YesYesNoNo88
853x43 6x36 smo_off_allo17.52920YesNoYesYes88
863x50 6x36 smo_off_allo23.85870YesYesYesYes78
872x56 2x57 smo_off_allo12.31690NoNoNoNo68
883x42 3x45 smo_off_allo14.771.10975YesYesNoNo97
893x45 4x45 smo_off_allo12.39560.561742NoNoNoNo79
903x48 4x45 smo_off_allo11.17560YesNoNoNo89
915x44 6x51 smo_off_allo12.64920.580823YesNoNoNo99
92NT.I95 NT.W92 smo_off_allo28.59550YesNoYesNo89
936x68 E3.I482 smo_off_allo10.52840NoNoNoNo54
94E2.D357 E2.Y367 smo_off_allo10.4060YesNoYesNo85
957x42 7x46 smo_off_allo10.32510.0236603YesNoYesYes89
966x65 Lig Shared93.389597.9385YesYesYesYes70
971x50 7x56 Shared10.224535.0722NoNoYesNo98
981x51 2x45 Shared17.956630.2402NoNoYesYes79
992x45 2x46 Shared30.262621.695YesYesYesNo98
1002x46 3x42 Shared20.253413.5742YesNoYesYes89
1013x34 4x50 Shared54.819811.0051YesNoYesYes89
1021x51 2x52 Shared18.813731.2187NoNoYesYes76
103NT.C193 NT.R199 smo_off098.5117NoNoNoYes00
104NT.P116 NT.R199 smo_off066.3344NoNoNoYes00
105NT.G191 NT.P116 smo_off065.1499NoNoNoNo00
106NT.G191 NT.W119 smo_off064.5576NoNoNoNo00
107NT.Q123 NT.W119 smo_off062.7808NoNoNoNo00
108NT.L79 NT.Q123 smo_off059.2271NoYesNoNo90
109NT.C127 NT.L79 smo_off021.3218NoNoNoYes99
110NT.C127 NT.C78 smo_off020.7295NoNoNoNo90
111NT.C78 NT.M131 smo_off015.3991NoNoNoNo00
112NT.C193 NT.C213 smo_off099.0093NoNoNoNo00
113NT.P196 NT.P220 smo_off014.0214NoNoNoNo00
1146x65 NT.Y207 smo_off052.3336YesYesNoYes70
115NT.L197 NT.Y207 smo_off050.785NoYesNoYes00
116NT.C213 NT.L197 smo_off0100NoNoNoYes00
1176x65 6x69 smo_off0.75648350.3736YesYesNoNo76
1186x69 NT.L197 smo_off050.1988NoNoNoYes60
1196x68 NT.P196 smo_off011.4753NoNoNoNo50
120NT.G212 NT.R199 smo_off039.4799NoNoNoYes00
121NT.G212 NT.W206 smo_off038.8052NoNoNoYes00
122NT.P203 NT.W206 smo_off036.933NoNoNoYes00
123NT.N202 NT.P203 smo_off036.2522NoYesNoNo00
124NT.N202 NT.S205 smo_off012.1011NoYesNoYes00
125E1.D298 NT.N202 smo_off012.9888NoYesNoYes00
126NT.K204 NT.N202 smo_off010.5014NoNoNoYes00
1273x28 E2.I389 smo_off011.4707NoNoNoYes70
1282x58 Lig smo_off025.1196YesYesYesYes70
1297x56 8x50 smo_off035.4974YesNoNoNo89
1308x47 8x50 smo_off2.1109435.9553NoNoNoNo99
1316x32 8x47 smo_off036.8681NoNoNoNo99
1326x32 7x55 smo_off1.6069835.892NoNoNoYes99
1336x33 7x55 smo_off054.7615NoNoNoYes89
1343x50 6x33 smo_off4.8198455.5659YesYesNoNo78
1353x50 5x66 smo_off063.4616YesYesNoYes78
1365x66 6x38 smo_off065.2453NoYesNoNo85
1375x62 6x38 smo_off065.607NoNoNoNo75
1385x62 6x41 smo_off071.4924NoNoNoYes75
1395x55 6x41 smo_off0.8242680.7504NoYesNoYes65
1405x55 6x48 smo_off082.7379NoYesNoYes66
1415x48 6x48 smo_off7.3483883.5668NoNoNoYes76
1425x48 6x55 smo_off081.0496NoNoNoNo76
1435x41 6x55 smo_off2.1830982.0662YesYesNoNo46
1445x41 6x58 smo_off4.3541582.6837YesYesNoNo47
1456x58 Lig smo_off5.0647283.3706NoNoYesYes70
1461x47 2x48 smo_off1.2210933.158NoNoNoNo99
1471x50 2x48 smo_off0.63295333.6389NoNoNoNo99
1481x47 2x52 smo_off2.6739332.6757NoNoYesYes96
1496x36 7x55 smo_off017.0393YesYesNoYes89
150E1.E305 E1.T307 smo_off017.3949NoNoNoNo00
151E1.R296 E1.T307 smo_off019.5625NoYesNoNo00
152E2x51 E2x52 smo_off1.5545111.357NoYesNoNo99
153E2x51 Lig smo_off012.1019NoYesYesYes90
1543x47 5x62 smo_off010.5716NoYesNoNo87
1553x47 5x61 smo_off3.1800716.5477NoYesYesYes88
156NT.F174 NT.V129 smo_off013.6222NoNoNoNo00
157NT.F166 NT.V129 smo_off014.2145NoYesNoNo00
158NT.D95 NT.F166 smo_off027.8368NoYesNoYes00
159NT.D95 NT.Y130 smo_off030.7981NoYesNoYes00
160NT.L106 NT.Y130 smo_off034.944NoNoNoYes00
161NT.L106 NT.L79 smo_off035.5363NoNoNoYes09
162NT.F166 NT.P164 smo_off011.2532NoYesNoNo00
163NT.L167 NT.P164 smo_off010.6609NoNoNoNo00
164NT.L167 NT.W163 smo_off010.0686NoNoNoYes00
165NT.L73 NT.M131 smo_off011.2532NoNoNoNo00
166NT.L73 NT.T88 smo_off010.0686NoNoNoNo00

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
6x65NT.Y207smo_off3.867501012
6x69NT.Y207smo_off9.147501022
6x65NT.I215smo_off4.7101012
NT.N219NT.P220smo_off6.112501012
NT.L221NT.N219smo_off5.147501011
NT.F222NT.N219smo_off8.157501021
E2.D384NT.N219smo_off5.72501011
LigNT.N219smo_off7.017501101
6x65NT.P220smo_off6.501012
NT.F222NT.L221smo_off3.65501021
6x65NT.L221smo_off4.262501011
LigNT.L221smo_off4.222501101
1x28NT.F222smo_off5.8301122
E2.V386NT.F222smo_off7.207500022
E3.P513NT.F222smo_off7.582500012
7x35NT.F222smo_off8.222501122
1x287x35Shared3.97757.951122
1x362x58Shared5.2853.520721
2x583x32Shared6.43758.581712
2x58E2.I389smo_off11.74501712
2x587x42Shared5.40753.421712
2x587x46Shared7.51758.021712
2x58Ligsmo_off4.7201710
3x32E2.I389smo_off3.837501022
E2.D382E2.Y394smo_off5.7500021
E2.D382E2.K395smo_off3.80500021
E2.D384E2.V386smo_off7.66501012
E2.D384E2.S387smo_off6.25501011
E2.D384E2.Y394smo_off7.47501011
E2.D384Ligsmo_off9.887501010
E2.I389E2.S387smo_off5.0301021
E2.S387E2.Y394smo_off4.452501011
E2.S387Ligsmo_off4.242501010
E2x51E2x52Shared3.60256.551012
E2.Y394E2x51smo_off9.282501011
5x47E2x51smo_off4.91500021
E2.Y394Ligsmo_off12.957501010
5x40E2.K395smo_off5.94500021
5x416x58Shared10.707520.291121
5x416x62smo_off5.8901121
5x446x51Shared9.3111.281112
5x446x54Shared10.42253.571111
5x44LigShared5.28254.871110
5x476x51smo_off6.572500022
6x477x41Shared5.4855.850021
6x507x41Shared8.66257.870021
6x517x41Shared11.477510.20021
6x536x61Shared5.3056.751122
6x537x37Shared11.046.311122
6x546x61Shared5.3056.71112
6x547x38Shared12.0157.81111
6x54Ligsmo_off4.58501110
6x586x62Shared7.9653.821111
6x58LigShared8.97758.541110
6x61E3.P513smo_off21.957501121
6x656x69Shared5.57257.871012
6x65LigShared8.71255.861010
E3.P513Ligsmo_off7.1400010
7x38LigShared20.62759.561010
7x41Ligsmo_off3.9100010
7x427x46Shared4.26254.871722
2x587x45smo_off4.072501712
E2.K395Ligsmo_off6.082500010
7x457x46smo_off7.77501022
E2x51Ligsmo_off3.852501010
6x65NT.I188smo_off_allo03.771012
NT.N192NT.P193smo_off_allo06.520112
NT.L194NT.N192smo_off_allo05.490111
NT.F195NT.N192smo_off_allo08.460111
E2.D357NT.N192smo_off_allo05.390111
E2.V359NT.N192smo_off_allo04.430121
LigNT.N192smo_off_allo012.111101
6x65NT.P193smo_off_allo05.781012
NT.F195NT.L194smo_off_allo04.870111
E3.I482NT.L194smo_off_allo02.850021
E3.P486NT.L194smo_off_allo04.930121
LigNT.L194smo_off_allo05.551101
1x28NT.F195smo_off_allo05.831121
E2.V359NT.F195smo_off_allo03.930121
E3.R485NT.F195smo_off_allo05.340121
E3.P486NT.F195smo_off_allo08.670121
7x35NT.F195smo_off_allo08.531121
LigNT.F195smo_off_allo02.931101
1x28E3.R485smo_off_allo09.31122
1x367x42smo_off_allo02.850722
2x58E2.I362smo_off_allo07.051712
3x33E2x51smo_off_allo04.131321
E2.D355E2.Y367smo_off_allo05.750021
E2.D355E2.K368smo_off_allo04.150021
E2.D357E2.V359smo_off_allo08.760112
E2.D357E2.S360smo_off_allo010.310112
E2.D357E2.Y367smo_off_allo04.60111
E2.D357Ligsmo_off_allo016.330110
E2.I362E2.S360smo_off_allo07.740022
E2.Y367E2x51smo_off_allo09.280111
5x44E2.Y367smo_off_allo03.091111
E2.Y367Ligsmo_off_allo015.040110
5x40E2.K368smo_off_allo013.990021
E2.K368Ligsmo_off_allo04.520010
6x507x37smo_off_allo03.420022
6x536x54smo_off_allo03.451121
6x61E3.P486smo_off_allo027.021122
6x62Ligsmo_off_allo03.191110
E3.P486E3.R485smo_off_allo02.880122
7x35E3.R485smo_off_allo04.861122
7x377x38smo_off_allo02.850021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
smo_off_allo 6D32-SMO-Cyclopamine-Cyclopamine
smo_off 5L7I-SMO-Vismodegib
4O9R-SMO-Cyclopamine
4QIM-SMO-PubChem 24905375
4JKV-SMO-Taladegib (LY2940680)
Network Difference
Value smo_off_allo smo_off
Imin 2.85 3.5675
Number of Linked Nodes 436 474
Number of Specific Nodes 203 (46.56%) 241  (50.84%)
Number of Shared Nodes 233 (53.44%) 233  (49.16%)
Number of Links 551 532
Number of Specific Links 401 (72.78%) 382  (71.80%)
Number of Shared Links 150 (27.22%) 150  (28.20%)
Number of Hubs 94 66
Number of Specific Hubs 71 (75.53%) 43  (65.15%)
Number of Shared Hubs 23 (24.47%) 23  (34.85%)
Average % Shared Neighbours (Jaccard) 14.10
Average % Shared Neighbours (Otsuka) 17.67
Average % Shared Neighbours (Overlap Coefficient) 21.19
Average % Shared Cliques (k3-6) 51.39
Graphlets Similarity 0.77902
Paths Difference
Value smo_off_allo smo_off
Number Of Nodes in MetaPath 98 75
Specific Nodes in MetaPath 82 (83.67%) 59  (78.67%)
Shared Nodes in MetaPath 233 (53.44%) 233  (53.44%)
Number Of Links MetaPath 102 71
Specific Links in MetaPath 95 (93.14%) 64  (90.14%)
Shared Links in MetaPath 150 (27.22%) 150  (27.22%)
Number of Shortest Paths 211136 223133
Length Of Smallest Path 3 3
Average Path Length 18.0412 23.395
Length of Longest Path 41 59
Minimum Path Strength 1.17 0.453125
Average Path Strength 6.34971 5.45271
Maximum Path Strength 22.965 20.325
Minimum Path Correlation 0.71 0.7
Average Path Correlation 0.962779 0.928515
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 3.57143 1.85185
Average % Of Corr. Nodes 61.0641 31.7472
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 45.9908 43.2942
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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