psnGPCR

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Orange: nodes, hubs and links specific of somatostatin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of somatostatin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	somatostatin_off Int. Strength	somatostatin_on Int. Strength	somatostatin_off Hub1?	somatostatin_on Hub1?	somatostatin_off Hub2?	somatostatin_on Hub2?	ConSurf1	ConSurf2
1	6x54	Lig	somatostatin_off	9.52	0	No	No	Yes	Yes	4	0
2	6x61	Lig	somatostatin_off	4.42	0	No	No	Yes	Yes	3	0
3	7x30	Lig	somatostatin_off	5.41	0	No	No	Yes	Yes	4	0
4	2x64	Lig	somatostatin_off	7.94	0	Yes	No	Yes	Yes	4	0
5	7x35	Lig	somatostatin_off	15.52	0	No	No	Yes	Yes	2	0
6	1x32	Lig	somatostatin_off	16.79	0	Yes	No	Yes	Yes	3	0
7	E1	Lig	somatostatin_off	13.88	0	No	No	Yes	Yes	4	0
8	1x30	1x32	somatostatin_off	8.77	0	No	No	Yes	No	4	3
9	1x32	2x64	somatostatin_off	4.43	0	Yes	No	Yes	No	3	4
10	1x32	E1	somatostatin_off	10.52	0	Yes	No	No	No	3	4
11	1x35	2x64	somatostatin_off	4.47	0	No	No	Yes	No	5	4
12	1x39	2x64	somatostatin_off	5.05	0	Yes	Yes	Yes	No	7	4
13	1x39	7x42	somatostatin_off	4.96	0	Yes	Yes	Yes	Yes	7	7
14	1x40	2x61	somatostatin_off	6.93	0	No	No	No	No	5	6
15	1x46	2x54	somatostatin_off	5.24	0	No	No	No	No	8	6
16	1x49	7x50	somatostatin_off	4.06	0	No	No	No	No	8	9
17	1x52	8x58	somatostatin_off	8.3	0	No	No	No	No	6	7
18	1x54	2x44	somatostatin_off	4.28	0	Yes	No	No	No	7	6
19	1x54	2x51	somatostatin_off	5.47	0	Yes	No	No	No	7	7
20	1x56	8x54	somatostatin_off	3.93	0	No	No	No	No	7	6
21	1x57	2x40	somatostatin_off	4.25	0	No	No	Yes	Yes	7	8
22	1x60	8x56	somatostatin_off	5.81	0	Yes	No	No	No	6	4
23	8x49	I1x49	somatostatin_off	6.99	0	No	No	No	No	5	5
24	2x40	I1x50	somatostatin_off	7.01	0	Yes	Yes	Yes	No	8	7
25	8x49	I1x50	somatostatin_off	8.41	0	No	No	Yes	No	5	7
26	8x50	I1x50	somatostatin_off	8.71	0	Yes	Yes	Yes	No	8	7
27	8x53	I1x50	somatostatin_off	6.13	0	No	No	Yes	No	5	7
28	2x38	I2x57	somatostatin_off	6.26	0	No	No	No	Yes	4	5
29	2x39	3x50	somatostatin_off	6.47	0	No	No	Yes	No	8	9
30	2x39	6x33	somatostatin_off	4.76	0	No	No	No	No	8	8
31	2x40	8x50	somatostatin_off	7.25	0	Yes	Yes	Yes	Yes	8	8
32	2x43	3x46	somatostatin_off	4.37	0	No	No	No	No	8	9
33	2x43	7x53	somatostatin_off	13.3	0	No	No	Yes	Yes	8	9
34	2x44	2x45	somatostatin_off	4.12	0	No	No	No	No	6	9
35	2x50	3x35	somatostatin_off	5.45	0	Yes	Yes	No	No	9	7
36	2x59	3x24	somatostatin_off	7.54	0	No	No	No	No	5	6
37	2x60	3x28	somatostatin_off	4.47	0	No	No	No	No	6	5
38	2x62	2x66	somatostatin_off	5.65	0	No	No	No	No	5	5
39	3x29	E2x50	somatostatin_off	4.86	0	No	No	No	No	5	9
40	3x34	3x38	somatostatin_off	7.6	0	No	Yes	Yes	No	5	7
41	3x35	7x46	somatostatin_off	5.96	0	No	No	No	No	7	8
42	3x36	6x52	somatostatin_off	7.89	0	Yes	Yes	Yes	Yes	7	7
43	3x37	5x461	somatostatin_off	4.52	0	Yes	Yes	No	No	6	6
44	3x43	6x40	somatostatin_off	5.96	0	No	No	No	Yes	9	8
45	3x44	5x54	somatostatin_off	6.08	0	No	No	Yes	No	7	7
46	3x46	6x37	somatostatin_off	7.61	0	No	No	No	No	9	8
47	3x49	3x50	somatostatin_off	4.76	0	No	No	Yes	No	8	9
48	3x50	6x33	somatostatin_off	3.92	0	Yes	No	No	No	9	8
49	3x50	6x34	somatostatin_off	11.64	0	Yes	No	No	No	9	7
50	3x50	6x37	somatostatin_off	3.92	0	Yes	No	No	No	9	8
51	3x54	6x30	somatostatin_off	5.7	0	No	No	Yes	Yes	8	6
52	I2x50	I2x51	somatostatin_off	5.08	0	No	No	No	No	8	5
53	4x40	4x43	somatostatin_off	7.43	0	No	No	No	No	4	1
54	4x56	5x42	somatostatin_off	6.31	0	Yes	No	No	No	4	4
55	4x57	4x62	somatostatin_off	8.75	0	No	No	No	No	7	5
56	4x59	4x62	somatostatin_off	4.24	0	No	No	No	No	4	5
57	4x60	5x42	somatostatin_off	4.17	0	No	No	No	No	8	4
58	E2	E2x51	somatostatin_off	5.81	0	Yes	Yes	No	No	3	4
59	5x34	E2	somatostatin_off	6.03	0	No	No	Yes	Yes	1	3
60	5x36	5x40	somatostatin_off	6.04	0	Yes	No	No	Yes	4	5
61	5x36	6x58	somatostatin_off	5.09	0	Yes	No	No	No	4	4
62	5x39	5x43	somatostatin_off	7.78	0	No	No	No	No	7	4
63	5x44	6x56	somatostatin_off	6.55	0	No	No	No	No	5	5
64	5x47	5x51	somatostatin_off	7.31	0	No	No	No	No	8	6
65	5x51	5x54	somatostatin_off	4.28	0	No	No	Yes	No	6	7
66	5x54	6x41	somatostatin_off	4.61	0	Yes	No	No	No	7	7
67	5x58	6x38	somatostatin_off	7.63	0	No	Yes	No	No	9	4
68	5x59	5x60	somatostatin_off	6.09	0	No	No	No	No	4	4
69	5x65	6x26	somatostatin_off	10.46	0	No	No	No	Yes	8	4
70	6x23	6x24	somatostatin_off	4.89	0	No	No	No	No	3	2
71	6x30	6x34	somatostatin_off	7.06	0	Yes	Yes	No	No	6	7
72	6x35	6x39	somatostatin_off	5.01	0	No	No	No	No	6	6
73	6x39	7x56	somatostatin_off	7.14	0	No	No	No	No	6	6
74	6x43	7x52	somatostatin_off	4.47	0	No	No	No	No	7	8
75	6x44	7x45	somatostatin_off	4.83	0	Yes	No	Yes	No	9	9
76	6x48	6x51	somatostatin_off	5.01	0	Yes	Yes	Yes	Yes	8	6
77	6x48	6x52	somatostatin_off	8.68	0	Yes	Yes	Yes	Yes	8	7
78	6x51	7x37	somatostatin_off	3.93	0	Yes	Yes	No	No	6	7
79	6x54	7x33	somatostatin_off	9.95	0	No	No	No	No	4	4
80	7x31	E3	somatostatin_off	6.69	0	No	No	No	No	3	2
81	7x41	7x42	somatostatin_off	4.99	0	No	No	Yes	Yes	7	7
82	7x53	8x50	somatostatin_off	8.25	0	Yes	Yes	Yes	Yes	9	8
83	8x47	8x50	somatostatin_off	13.14	0	No	No	Yes	Yes	8	8
84	8x52	8x63	somatostatin_off	5.75	0	No	No	No	No	5	3
85	8x55	8x63	somatostatin_off	4.07	0	No	No	No	No	4	3
86	8x56	8x63	somatostatin_off	9.79	0	No	No	No	No	4	3
87	1x53	7x53	somatostatin_off	3.79	0	No	No	Yes	Yes	9	9
88	1x55	8x57	somatostatin_off	3.79	0	No	No	Yes	No	3	5
89	1x43	2x58	somatostatin_off	3.77	0	No	No	No	No	6	8
90	1x40	2x62	somatostatin_off	3.73	0	No	No	No	No	5	5
91	1x31	Lig	somatostatin_off	3.72	0	No	No	Yes	Yes	4	0
92	3x43	6x44	somatostatin_off	3.65	0	No	No	Yes	No	9	9
93	3x51	5x61	somatostatin_off	3.63	0	Yes	Yes	No	No	8	9
94	6x36	7x53	somatostatin_off	3.59	0	No	No	Yes	Yes	8	9
95	1x53	2x47	somatostatin_off	3.39	0	No	No	No	No	9	9
96	1x30	1x33	somatostatin_off	3.36	0	No	No	No	No	4	4
97	3x29	4x65	somatostatin_off	3.22	0	No	No	No	No	5	4
98	1x36	2x64	somatostatin_off	3.17	0	No	No	Yes	No	5	4
99	3x27	3x30	somatostatin_off	3.17	0	No	No	No	No	5	6
100	4x46	4x47	somatostatin_off	3.01	0	No	No	No	No	7	4
101	1x52	8x57	somatostatin_off	2.98	0	No	No	Yes	No	6	5
102	8x57	8x58	somatostatin_off	2.98	0	Yes	No	No	No	5	7
103	6x43	7x45	somatostatin_off	2.96	0	No	No	Yes	No	7	9
104	3x48	5x53	somatostatin_off	2.94	0	No	No	No	No	6	6
105	5x41	5x45	somatostatin_off	2.94	0	No	No	No	No	5	4
106	2x41	I1x51	somatostatin_off	2.91	0	No	Yes	No	No	5	7
107	1x47	2x54	somatostatin_off	2.83	0	No	No	No	No	6	6
108	3x21	E1x50	somatostatin_off	2.81	0	No	No	Yes	Yes	7	8
109	1x47	2x55	somatostatin_off	2.77	0	No	No	No	No	6	5
110	3x26	4x65	somatostatin_off	2.77	0	No	No	No	No	6	4
111	4x55	4x59	somatostatin_off	2.77	0	No	No	No	No	3	4
112	7x54	8x54	somatostatin_off	2.77	0	No	No	No	No	7	6
113	2x42	4x42	somatostatin_off	2.67	0	Yes	Yes	No	No	7	7
114	8x55	8x61	somatostatin_off	2.66	0	No	No	No	No	4	4
115	2x53	3x31	somatostatin_off	2.62	0	Yes	Yes	No	No	6	5
116	5x44	5x48	somatostatin_off	2.44	0	No	No	No	No	5	4
117	7x36	7x40	somatostatin_off	2.44	0	No	No	No	No	5	7
118	2x52	4x50	somatostatin_off	2.28	0	No	No	Yes	Yes	7	9
119	2x56	2x58	somatostatin_off	2.03	0	No	No	No	No	6	8
120	3x33	4x57	somatostatin_off	1.76	0	No	No	No	No	4	7
121	3x33	4x61	somatostatin_off	1.76	0	No	No	No	Yes	4	3
122	7x31	7x32	somatostatin_off	1.74	0	No	No	No	No	3	1
123	1x42	7x47	somatostatin_off	1.71	0	No	No	No	No	7	8
124	3x42	4x49	somatostatin_off	1.71	0	No	No	No	No	8	6
125	2x38	4x39	somatostatin_off	1.69	0	No	No	No	No	4	3
126	2x41	4x39	somatostatin_off	1.69	0	No	Yes	No	No	5	3
127	3x38	3x42	somatostatin_off	1.69	0	Yes	No	No	No	7	8
128	5x64	I2x50	somatostatin_off	1.67	0	No	No	No	No	5	8
129	3x23	3x24	somatostatin_off	1.62	0	No	No	No	No	1	6
130	4x52	4x56	somatostatin_off	1.6	0	No	No	Yes	No	4	4
131	8x62	8x64	somatostatin_off	1.6	0	No	No	No	No	2	1
132	7x48	7x52	somatostatin_off	1.58	0	No	No	No	No	6	8
133	3x39	3x40	somatostatin_off	1.55	0	No	No	No	No	9	8
134	4x41	4x45	somatostatin_off	1.52	0	No	No	No	No	5	5
135	5x48	5x52	somatostatin_off	1.47	0	No	No	No	No	4	4
136	5x33	5x36	somatostatin_off	1.45	0	No	No	Yes	No	2	4
137	6x28	6x31	somatostatin_off	1.44	0	No	No	No	No	4	5
138	6x31	6x32	somatostatin_off	1.44	0	No	No	No	No	5	7
139	5x56	5x60	somatostatin_off	1.22	0	No	No	No	No	5	4
140	Lig	Lig	Shared	140.8	26.2287	Yes	Yes	Yes	Yes	0	0
141	5x36	Lig	Shared	23.28	6.775	Yes	No	Yes	Yes	4	0
142	E3	Lig	Shared	14.37	3.41375	No	No	Yes	Yes	2	0
143	7x31	Lig	Shared	14.25	2.595	No	No	Yes	Yes	3	0
144	7x34	Lig	Shared	17.11	11.6425	No	No	Yes	Yes	4	0
145	3x29	Lig	Shared	5.61	3.29625	No	No	Yes	Yes	5	0
146	E2x51	Lig	Shared	8.19	11.4025	No	No	Yes	Yes	4	0
147	E2x52	Lig	Shared	7.93	4.4675	No	Yes	Yes	Yes	5	0
148	3x32	Lig	Shared	11.06	10.2375	No	Yes	Yes	Yes	6	0
149	3x36	Lig	Shared	8.14	8.17125	Yes	Yes	Yes	Yes	7	0
150	1x35	1x39	Shared	8.21	2.86625	No	No	Yes	Yes	5	7
151	1x35	7x35	Shared	6.79	4.3725	No	No	No	No	5	2
152	1x36	2x65	Shared	5.03	3.74125	No	No	No	No	5	5
153	1x37	1x41	Shared	6.55	1.8025	No	No	No	No	6	5
154	1x39	2x61	Shared	4	3.66875	Yes	Yes	No	No	7	6
155	1x43	2x57	Shared	4.76	3.6625	No	No	No	Yes	6	7
156	1x47	2x51	Shared	5.3	4.64	No	No	No	No	6	7
157	1x50	2x50	Shared	8.17	9.255	No	No	Yes	Yes	9	9
158	1x50	7x50	Shared	9.77	8.35125	No	No	No	No	9	9
159	1x51	2x51	Shared	8.47	1.0575	No	No	No	No	5	7
160	1x54	2x48	Shared	5.89	2.425	Yes	No	No	No	7	7
161	1x55	1x59	Shared	16.46	3.62125	No	No	No	No	3	4
162	1x56	8x53	Shared	6.46	1.8675	No	No	No	No	7	5
163	1x57	8x50	Shared	5.02	3.14	No	No	Yes	Yes	7	8
164	1x58	2x44	Shared	4.15	3.635	No	No	No	No	3	6
165	1x59	1x60	Shared	18.52	2.445	No	No	Yes	No	4	6
166	2x37	2x40	Shared	13.16	4.20375	No	No	Yes	Yes	7	8
167	2x42	3x45	Shared	10.09	5.8375	Yes	Yes	No	No	7	7
168	2x42	3x46	Shared	4.79	6.4975	Yes	Yes	No	No	7	9
169	2x42	4x45	Shared	6.04	3.6275	Yes	Yes	No	No	7	5
170	2x45	4x46	Shared	14.62	12.7925	No	No	No	No	9	7
171	2x45	4x50	Shared	6.78	6.4975	No	No	Yes	Yes	9	9
172	2x50	7x46	Shared	10.43	6.44	Yes	Yes	No	No	9	8
173	2x50	7x49	Shared	4.09	4.20875	Yes	Yes	No	Yes	9	9
174	2x53	3x32	Shared	5.97	4.62875	Yes	Yes	No	Yes	6	6
175	2x53	3x35	Shared	21.75	4.2275	Yes	Yes	No	No	6	7
176	2x53	7x42	Shared	12.38	14.7	Yes	Yes	Yes	Yes	6	7
177	2x57	7x42	Shared	4.69	8.01125	No	Yes	Yes	Yes	7	7
178	2x59	E1x52	Shared	12.86	7.1025	No	No	Yes	Yes	5	6
179	2x59	3x28	Shared	3.93	3.76625	No	No	No	No	5	5
180	2x63	E1x50	Shared	10.95	5.82625	No	No	Yes	Yes	5	8
181	E1x49	E1x51	Shared	4.58	6.1	No	No	No	No	4	4
182	E1x49	E2	Shared	11.22	6.95	No	No	Yes	Yes	4	3
183	E1x50	E1x52	Shared	11.02	16.0338	Yes	Yes	Yes	Yes	8	6
184	3x25	E1x50	Shared	3.92	8.32625	No	No	Yes	Yes	9	8
185	E1x50	E2	Shared	6.93	3.07375	Yes	Yes	Yes	Yes	8	3
186	E1x50	E2x50	Shared	18.28	8.49	Yes	Yes	No	No	8	9
187	E1x51	E1x52	Shared	11.56	4.515	No	No	Yes	Yes	4	6
188	3x22	E2	Shared	5.23	5.27625	No	No	Yes	Yes	3	3
189	3x25	E2x50	Shared	7.28	6.825	No	No	No	No	9	9
190	3x30	4x62	Shared	6.02	4.61875	No	No	No	No	6	5
191	3x32	7x42	Shared	4.6	5.46	No	Yes	Yes	Yes	6	7
192	3x34	4x50	Shared	4.7	3.1575	No	Yes	Yes	Yes	5	9
193	3x36	3x37	Shared	10.54	3.77	Yes	Yes	Yes	Yes	7	6
194	3x36	6x48	Shared	7.67	6.6075	Yes	Yes	Yes	Yes	7	8
195	3x37	3x41	Shared	4.29	3.34875	Yes	Yes	No	No	6	6
196	3x37	4x56	Shared	9.18	8.3575	Yes	Yes	Yes	No	6	4
197	3x37	4x57	Shared	5.02	4.17625	Yes	Yes	No	No	6	7
198	3x38	4x50	Shared	9.7	19.71	Yes	No	Yes	Yes	7	9
199	3x38	4x53	Shared	9.59	4.39875	Yes	No	No	No	7	7
200	3x40	5x50	Shared	8.47	2.5775	No	No	No	Yes	8	9
201	3x40	6x44	Shared	16.33	3.3925	No	No	Yes	No	8	9
202	3x47	5x54	Shared	4.64	7.74	No	No	Yes	No	9	7
203	3x47	5x58	Shared	10.17	5.88375	No	No	No	Yes	9	9
204	3x49	I2x57	Shared	11.91	10.4225	No	No	No	Yes	8	5
205	3x51	3x55	Shared	10.09	8.8325	Yes	Yes	No	No	8	7
206	3x51	3x56	Shared	4.36	4.90125	Yes	Yes	No	Yes	8	5
207	3x51	5x57	Shared	4.03	5.7125	Yes	Yes	No	No	8	7
208	3x51	5x60	Shared	4.13	7.4575	Yes	Yes	No	No	8	4
209	3x52	I2x53	Shared	6.01	3.4775	No	No	No	No	4	5
210	3x53	I2x57	Shared	6.91	5.185	No	No	No	Yes	8	5
211	3x54	5x61	Shared	4.61	5.185	No	No	No	No	8	9
212	3x55	3x56	Shared	9.69	8.64875	No	No	No	Yes	7	5
213	3x55	5x64	Shared	6.07	6.26125	No	No	No	No	7	5
214	4x38	4x39	Shared	12.97	1.98	No	Yes	No	No	6	3
215	4x56	5x46	Shared	4.47	2.6075	Yes	No	No	No	4	4
216	4x61	E2x52	Shared	7.36	5.02875	No	Yes	No	Yes	3	5
217	4x63	4x64	Shared	8.46	7.49875	No	No	No	No	4	4
218	4x64	E2	Shared	23.02	17.5725	No	No	Yes	Yes	4	3
219	E2	E2	Shared	55.97	36.53	Yes	Yes	Yes	Yes	3	3
220	E2	E2x52	Shared	15.27	5.34375	Yes	Yes	No	Yes	3	5
221	5x35	E2	Shared	38.4	9.37375	No	No	Yes	Yes	3	3
222	5x39	E2	Shared	15.03	8.64625	No	No	Yes	Yes	7	3
223	5x37	6x59	Shared	9.52	2.5725	No	No	No	No	3	4
224	5x42	5x46	Shared	8.21	4.69	No	No	No	No	4	4
225	5x44	6x52	Shared	5.16	10.7063	No	No	Yes	Yes	5	7
226	5x47	6x49	Shared	8.53	5.07	No	No	No	Yes	8	5
227	5x47	6x52	Shared	20.63	8.76875	No	No	Yes	Yes	8	7
228	5x49	5x50	Shared	5.3	2.585	No	No	No	Yes	5	9
229	5x51	6x45	Shared	9.99	3.11875	No	No	No	No	6	6
230	5x59	5x63	Shared	4.28	0.71375	No	No	No	No	4	3
231	6x26	6x30	Shared	11.63	3.78	No	Yes	Yes	Yes	4	6
232	6x26	6x31	Shared	13.61	6.19	No	Yes	No	No	4	5
233	6x27	6x29	Shared	4.59	6.26	No	No	No	No	3	5
234	6x36	7x56	Shared	5.65	2.27375	No	No	No	No	8	6
235	6x44	6x48	Shared	18.04	11.1525	Yes	No	Yes	Yes	9	8
236	6x46	6x47	Shared	4.19	0.97	No	No	No	No	6	8
237	6x47	7x45	Shared	11.02	8.85875	No	No	Yes	No	8	9
238	6x48	7x41	Shared	18.19	7.9525	Yes	Yes	No	No	8	7
239	6x48	7x45	Shared	6.78	11.4412	Yes	Yes	Yes	No	8	9
240	6x49	6x50	Shared	4.93	2.905	No	Yes	No	No	5	9
241	6x49	6x53	Shared	4.28	1.985	No	Yes	No	No	5	5
242	6x51	6x52	Shared	8.25	3.73875	Yes	Yes	Yes	Yes	6	7
243	6x51	6x55	Shared	14.5	8.68625	Yes	Yes	No	No	6	6
244	6x51	7x41	Shared	5.19	4.60375	Yes	Yes	No	No	6	7
245	6x54	7x34	Shared	13.93	3.655	No	No	No	No	4	4
246	7x27	7x30	Shared	5.9	2.94875	No	No	No	No	1	4
247	7x34	7x38	Shared	7.87	3.9775	No	No	No	No	4	6
248	7x38	7x42	Shared	5.05	4.7325	No	No	Yes	Yes	6	7
249	7x49	7x53	Shared	4.65	4.21625	No	Yes	Yes	Yes	9	9
250	8x47	8x49	Shared	4.04	2.79375	No	No	No	No	8	5
251	1x60	8x53	Shared	3.82	5.9325	Yes	No	No	No	6	5
252	1x60	8x57	Shared	3.79	1.26125	Yes	No	Yes	No	6	5
253	2x62	E1x52	Shared	3.73	2.8	No	No	Yes	Yes	5	6
254	3x51	3x52	Shared	3.52	2.28625	Yes	Yes	No	No	8	4
255	7x27	7x28	Shared	3.5	1.53125	No	No	No	No	1	3
256	2x49	3x38	Shared	3.36	1.68	No	No	Yes	No	8	7
257	6x50	7x40	Shared	3.28	4.105	No	No	No	No	9	7
258	3x48	5x57	Shared	3.27	2.52875	No	No	No	No	6	7
259	1x54	2x47	Shared	3.25	2.03	Yes	No	No	No	7	9
260	2x41	4x42	Shared	3.25	4.06	No	Yes	No	No	5	7
261	4x38	4x40	Shared	3.2	0.66625	No	Yes	No	No	6	4
262	1x34	1x38	Shared	3.07	0.57625	No	No	No	No	5	5
263	1x38	7x39	Shared	3.07	5.00875	No	No	No	Yes	5	5
264	5x40	6x59	Shared	3.07	3.4325	No	Yes	No	No	5	4
265	5x40	5x41	Shared	2.94	1.35125	No	Yes	No	No	5	5
266	2x54	2x57	Shared	2.83	2.22625	No	No	No	Yes	6	7
267	2x46	2x50	Shared	2.75	3.22375	No	Yes	Yes	Yes	9	9
268	2x46	7x49	Shared	2.75	3.775	No	Yes	No	Yes	9	9
269	8x51	8x55	Shared	2.71	0.17	No	No	No	No	8	4
270	6x27	6x30	Shared	2.7	3.36625	No	No	Yes	Yes	3	6
271	1x39	7x39	Shared	2.52	7.59625	Yes	Yes	No	Yes	7	5
272	7x51	7x55	Shared	2.51	2.04375	No	No	No	No	6	7
273	4x41	I2x56	Shared	2.43	3.97875	No	No	No	No	5	3
274	1x46	7x47	Shared	1.96	3.43	No	No	No	No	8	8
275	1x48	1x49	Shared	1.96	2.88	No	No	No	No	5	8
276	5x32	5x33	Shared	1.86	0.9975	No	No	No	No	2	2
277	4x51	4x54	Shared	1.71	1.33375	No	No	No	No	4	3
278	7x27	7x29	Shared	1.68	0.63	No	No	No	No	1	1
279	1x45	7x47	Shared	1.64	1.43125	No	No	No	No	4	8
280	6x59	6x60	Shared	1.62	2.1325	No	No	No	No	4	4
281	I2x51	I2x52	Shared	1.45	1.39625	No	No	No	No	5	4
282	3x34	4x54	Shared	1.43	4.385	No	Yes	No	No	5	3
283	8x47	8x48	Shared	1.33	1.10375	No	No	No	No	8	5
284	E2	Lig	somatostatin_on	0	4.9225	Yes	Yes	Yes	Yes	3	0
285	5x43	Lig	somatostatin_on	0	5.575	No	No	Yes	Yes	4	0
286	6x51	Lig	somatostatin_on	0	8.8425	Yes	Yes	Yes	Yes	6	0
287	7x42	Lig	somatostatin_on	0	4.5675	Yes	Yes	Yes	Yes	7	0
288	2x63	Lig	somatostatin_on	0	4.19125	No	No	Yes	Yes	5	0
289	1x42	7x39	somatostatin_on	0	3.10375	No	No	No	Yes	7	5
290	1x50	2x51	somatostatin_on	0	6.08	No	No	No	No	9	7
291	1x54	1x58	somatostatin_on	0	3.0325	Yes	No	No	No	7	3
292	1x56	8x50	somatostatin_on	0	5.245	No	No	Yes	Yes	7	8
293	1x57	2x44	somatostatin_on	0	3.92375	No	No	No	No	7	6
294	2x37	2x39	somatostatin_on	0	3.72875	No	No	No	No	7	8
295	2x38	2x42	somatostatin_on	0	3.45125	No	No	Yes	Yes	4	7
296	2x41	4x43	somatostatin_on	0	3.09	No	Yes	No	No	5	1
297	2x42	3x49	somatostatin_on	0	9.76875	Yes	Yes	No	No	7	8
298	2x46	3x42	somatostatin_on	0	3.77125	No	Yes	No	No	9	8
299	2x46	3x43	somatostatin_on	0	3.2875	No	Yes	No	No	9	9
300	2x50	7x50	somatostatin_on	0	4.025	Yes	Yes	No	No	9	9
301	2x52	3x35	somatostatin_on	0	7.8975	No	No	No	No	7	7
302	2x53	3x36	somatostatin_on	0	3.38375	Yes	Yes	Yes	Yes	6	7
303	2x53	7x46	somatostatin_on	0	4.125	Yes	Yes	No	No	6	8
304	2x57	2x58	somatostatin_on	0	4.29125	No	Yes	No	No	7	8
305	2x64	7x35	somatostatin_on	0	5.48	Yes	No	No	No	4	2
306	2x66	E1x49	somatostatin_on	0	6.75	No	No	No	No	5	4
307	3x25	E2	somatostatin_on	0	3.12375	No	No	Yes	Yes	9	3
308	3x31	3x35	somatostatin_on	0	4.24875	No	No	No	No	5	7
309	3x34	4x53	somatostatin_on	0	5.505	No	Yes	No	No	5	7
310	3x37	5x43	somatostatin_on	0	3.24125	Yes	Yes	No	No	6	4
311	3x40	6x48	somatostatin_on	0	4.59	No	No	Yes	Yes	8	8
312	3x43	7x49	somatostatin_on	0	3.43125	No	No	No	Yes	9	9
313	3x43	7x53	somatostatin_on	0	6.74	No	No	Yes	Yes	9	9
314	3x44	5x50	somatostatin_on	0	3.0625	No	No	No	Yes	7	9
315	3x50	5x58	somatostatin_on	0	7.9725	Yes	No	No	Yes	9	9
316	3x50	7x53	somatostatin_on	0	4.76	Yes	No	Yes	Yes	9	9
317	3x56	I2x52	somatostatin_on	0	4.53125	No	Yes	No	No	5	4
318	4x57	4x61	somatostatin_on	0	3.9	No	No	No	Yes	7	3
319	4x59	4x60	somatostatin_on	0	5.13125	No	No	No	No	4	8
320	4x61	5x39	somatostatin_on	0	4.0825	No	Yes	No	No	3	7
321	E2	E2x50	somatostatin_on	0	3.355	Yes	Yes	No	No	3	9
322	5x36	E2	somatostatin_on	0	4.38625	Yes	No	Yes	Yes	4	3
323	5x32	5x35	somatostatin_on	0	4.67625	No	No	No	No	2	3
324	5x40	6x55	somatostatin_on	0	3.5475	No	Yes	No	No	5	6
325	5x43	6x52	somatostatin_on	0	3.2775	No	No	Yes	Yes	4	7
326	5x44	5x47	somatostatin_on	0	8.84125	No	No	No	No	5	8
327	5x54	5x58	somatostatin_on	0	7.1025	Yes	No	No	Yes	7	9
328	5x58	6x37	somatostatin_on	0	10.255	No	Yes	No	No	9	8
329	5x58	6x40	somatostatin_on	0	3.62375	No	Yes	No	Yes	9	8
330	5x62	6x34	somatostatin_on	0	4.075	No	Yes	No	No	5	7
331	5x64	5x68	somatostatin_on	0	3.43	No	No	No	No	5	0
332	5x65	6x30	somatostatin_on	0	5.29125	No	No	Yes	Yes	8	6
333	5x66	I3	somatostatin_on	0	4.605	No	No	No	Yes	4	0
334	5x66	6x30	somatostatin_on	0	12.8387	No	No	Yes	Yes	4	6
335	6x26	I3	somatostatin_on	0	4.03625	No	Yes	No	Yes	4	0
336	6x36	6x40	somatostatin_on	0	5.06	No	No	No	Yes	8	8
337	6x40	7x53	somatostatin_on	0	14.0975	No	Yes	Yes	Yes	8	9
338	6x45	6x49	somatostatin_on	0	4.0625	No	No	No	Yes	6	5
339	6x51	7x38	somatostatin_on	0	3.42	Yes	Yes	No	No	6	6
340	7x52	7x53	somatostatin_on	0	3.07625	No	No	Yes	Yes	8	9
341	7x55	8x50	somatostatin_on	0	3.48375	No	No	Yes	Yes	7	8
342	8x49	8x52	somatostatin_on	0	3.73125	No	No	No	No	5	5
343	2x40	I1x48	somatostatin_on	0	3.32125	Yes	Yes	No	No	8	5
344	4x43	I1x50	somatostatin_on	0	3.96	No	No	Yes	No	1	7
345	2x40	I1x51	somatostatin_on	0	5.07125	Yes	Yes	No	No	8	7
346	2x45	3x42	somatostatin_on	0	5.50875	No	No	No	No	9	8
347	3x34	4x57	somatostatin_on	0	4.05375	No	Yes	No	No	5	7
348	I2x55	I2x56	somatostatin_on	0	6.8575	No	No	No	No	4	3
349	5x51	6x44	somatostatin_on	0	3.51	No	No	Yes	No	6	9
350	6x40	7x52	somatostatin_on	0	3.97625	No	Yes	No	No	8	8
351	6x55	Lig	somatostatin_on	0	9.66	No	No	Yes	Yes	6	0
352	2x60	Lig	somatostatin_on	0	8.1525	No	No	Yes	Yes	6	0
353	2x41	I1x50	somatostatin_on	0	3.27875	No	Yes	Yes	No	5	7
354	3x46	3x50	somatostatin_on	0	7.9025	No	No	Yes	No	9	9
355	7x45	7x49	somatostatin_on	0	4.08625	Yes	No	No	Yes	9	9
356	5x66	6x26	somatostatin_on	0	7.4625	No	No	No	Yes	4	4
357	6x54	7x37	somatostatin_on	0	4.04	No	No	No	No	4	7
358	2x43	8x50	somatostatin_on	0	3.35	No	No	Yes	Yes	8	8
359	6x24	I3	somatostatin_on	0	3.3275	No	No	No	Yes	2	0
360	2x56	3x32	somatostatin_on	0	2.945	No	No	No	Yes	6	6
361	5x65	6x33	somatostatin_on	0	2.915	No	No	No	No	8	8
362	7x36	7x39	somatostatin_on	0	2.9025	No	No	No	Yes	5	5
363	6x39	7x52	somatostatin_on	0	2.83875	No	No	No	No	6	8
364	2x54	7x47	somatostatin_on	0	2.835	No	No	No	No	6	8
365	1x36	1x39	somatostatin_on	0	2.8175	No	No	Yes	Yes	5	7
366	3x47	5x57	somatostatin_on	0	2.795	No	No	No	No	9	7
367	5x461	5x50	somatostatin_on	0	2.79125	No	No	No	Yes	6	9
368	1x39	2x57	somatostatin_on	0	2.78375	Yes	Yes	No	Yes	7	7
369	3x41	4x49	somatostatin_on	0	2.78375	No	No	No	No	6	6
370	7x54	8x50	somatostatin_on	0	2.71875	No	No	Yes	Yes	7	8
371	3x22	3x26	somatostatin_on	0	2.71	No	No	No	No	3	6
372	1x32	1x35	somatostatin_on	0	2.7025	Yes	No	No	No	3	5
373	4x38	I2x57	somatostatin_on	0	2.665	No	Yes	No	Yes	6	5
374	6x58	Lig	somatostatin_on	0	2.66125	No	No	Yes	Yes	4	0
375	2x40	I1x49	somatostatin_on	0	2.6225	Yes	Yes	No	No	8	5
376	2x37	I2x57	somatostatin_on	0	2.5875	No	No	No	Yes	7	5
377	2x50	3x39	somatostatin_on	0	2.57625	Yes	Yes	No	No	9	9
378	7x33	E3	somatostatin_on	0	2.57	No	No	No	No	4	2
379	2x41	4x46	somatostatin_on	0	2.53	No	Yes	No	No	5	7
380	5x52	5x56	somatostatin_on	0	2.5125	No	No	No	No	4	5
381	5x45	5x48	somatostatin_on	0	2.44375	No	No	No	No	4	4
382	6x54	6x57	somatostatin_on	0	2.4375	No	No	No	No	4	4
383	3x44	5x53	somatostatin_on	0	2.36	No	No	No	No	7	6
384	3x24	E1x52	somatostatin_on	0	2.355	No	No	Yes	Yes	6	6
385	2x44	I1x50	somatostatin_on	0	2.29875	No	No	Yes	No	6	7
386	1x53	7x50	somatostatin_on	0	2.21	No	No	No	No	9	9
387	5x58	6x41	somatostatin_on	0	2.2075	No	Yes	No	No	9	7
388	4x60	5x39	somatostatin_on	0	2.1675	No	No	No	No	8	7
389	3x32	3x33	somatostatin_on	0	2.0975	No	Yes	No	No	6	4
390	E1	E2	somatostatin_on	0	1.9325	No	No	Yes	Yes	4	3
391	6x23	6x25	somatostatin_on	0	1.9175	No	No	No	No	3	3
392	5x62	6x30	somatostatin_on	0	1.9075	No	Yes	Yes	Yes	5	6
393	5x40	6x56	somatostatin_on	0	1.88625	No	Yes	No	No	5	5
394	6x23	6x27	somatostatin_on	0	1.8825	No	No	No	No	3	3
395	8x52	I1x51	somatostatin_on	0	1.82625	No	No	No	No	5	7
396	4x65	E2x52	somatostatin_on	0	1.815	No	No	No	Yes	4	5
397	5x67	I3	somatostatin_on	0	1.7125	No	No	No	Yes	5	0
398	6x43	6x47	somatostatin_on	0	1.71	No	No	No	No	7	8
399	4x47	4x50	somatostatin_on	0	1.7075	No	No	Yes	Yes	4	9
400	6x60	6x61	somatostatin_on	0	1.67	No	No	No	No	4	3
401	5x58	5x61	somatostatin_on	0	1.66375	No	Yes	No	No	9	9
402	8x50	8x54	somatostatin_on	0	1.6075	Yes	Yes	No	No	8	6
403	5x62	6x37	somatostatin_on	0	1.56875	No	Yes	No	No	5	8
404	3x30	4x61	somatostatin_on	0	1.55	No	No	No	Yes	6	3
405	3x56	I2x50	somatostatin_on	0	1.53	No	Yes	No	No	5	8
406	4x38	4x41	somatostatin_on	0	1.455	No	Yes	No	No	6	5
407	8x48	8x51	somatostatin_on	0	1.41125	No	No	No	No	5	8
408	6x31	6x35	somatostatin_on	0	1.3925	No	No	No	No	5	6
409	5x44	5x45	somatostatin_on	0	1.38625	No	No	No	No	5	4
410	5x55	6x41	somatostatin_on	0	1.315	No	No	No	No	5	7
411	1x36	1x40	somatostatin_on	0	1.29625	No	No	No	No	5	5
412	4x48	4x51	somatostatin_on	0	1.2825	No	No	No	No	4	4
413	1x42	7x43	somatostatin_on	0	1.27125	No	No	No	No	7	5
414	7x32	7x35	somatostatin_on	0	1.2575	No	No	No	No	1	2
415	6x32	6x35	somatostatin_on	0	1.24	No	No	No	No	7	6
416	8x54	8x58	somatostatin_on	0	1.21875	No	No	No	No	6	7
417	1x33	1x37	somatostatin_on	0	1.20125	No	No	No	No	4	6
418	3x41	4x52	somatostatin_on	0	1.14625	No	No	No	No	6	4
419	5x37	5x38	somatostatin_on	0	1.1375	No	No	No	No	3	4
420	1x29	1x31	somatostatin_on	0	1.12625	No	No	No	No	0	4
421	2x55	2x56	somatostatin_on	0	1.125	No	No	No	No	5	6
422	7x30	E3	somatostatin_on	0	1.07125	No	No	No	No	4	2
423	1x40	1x44	somatostatin_on	0	0.9425	No	No	No	No	5	4
424	4x41	4x44	somatostatin_on	0	0.9375	No	No	No	No	5	1
425	1x29	1x30	somatostatin_on	0	0.92125	No	No	No	No	0	4
426	6x25	6x28	somatostatin_on	0	0.8975	No	No	No	No	3	4
427	1x49	7x51	somatostatin_on	0	0.8825	No	No	No	No	8	6
428	6x42	6x43	somatostatin_on	0	0.8	No	No	No	No	5	7
429	1x52	7x55	somatostatin_on	0	0.76125	No	No	No	No	6	7
430	3x21	E1x52	somatostatin_on	0	0.755	No	No	Yes	Yes	7	6
431	1x38	1x41	somatostatin_on	0	0.715	No	No	No	No	5	5
432	3x23	3x26	somatostatin_on	0	0.655	No	No	No	No	1	6
433	3x27	3x31	somatostatin_on	0	0.6	No	No	No	No	5	5
434	6x34	6x38	somatostatin_on	0	0.6	No	No	No	No	7	4
435	8x56	8x57	somatostatin_on	0	0.55375	No	No	Yes	No	4	5
436	I2x54	I2x57	somatostatin_on	0	0.51875	No	No	No	Yes	4	5
437	5x34	5x36	somatostatin_on	0	0.5	No	No	Yes	No	1	4
438	5x62	5x63	somatostatin_on	0	0.46	No	Yes	No	No	5	3
439	6x43	7x48	somatostatin_on	0	0.425	No	No	No	No	7	6
440	1x30	1x34	somatostatin_on	0	0.3975	No	No	No	No	4	5
441	5x51	5x52	somatostatin_on	0	0.3725	No	No	No	No	6	4

Orange: nodes, hubs and links specific of somatostatin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of somatostatin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	somatostatin_off Avg Int. Strength	somatostatin_on Avg Int. Strength	somatostatin_off Num Of Links	somatostatin_on Num Of Links	ConSurf
1	1x32	somatostatin_off	10.1275	2.7025	4	1	3
2	1x54	somatostatin_off	4.7225	2.49583	4	3	7
3	1x60	somatostatin_off	7.985	3.21292	4	3	6
4	I1x50	somatostatin_off	7.565	3.17917	4	3	7
5	2x64	somatostatin_off	5.012	5.48	5	1	4
6	3x38	somatostatin_off	6.388	8.59625	5	3	7
7	3x50	somatostatin_off	6.142	6.87833	5	3	9
8	4x56	somatostatin_off	5.39	5.4825	4	2	4
9	5x36	somatostatin_off	8.965	3.88708	4	3	4
10	5x54	somatostatin_off	4.9025	7.42125	4	2	7
11	6x44	somatostatin_off	10.7125	6.01833	4	3	9
12	7x45	somatostatin_off	6.3975	8.12875	4	3	9
13	8x57	somatostatin_off	3.385	0.9075	4	2	5
14	Lig	Shared	24.6705	8.58059	19	19	0
15	1x39	Shared	4.948	3.9465	5	5	7
16	2x40	Shared	7.9175	3.80469	4	4	8
17	2x42	Shared	5.8975	5.8365	4	5	7
18	2x50	Shared	6.178	4.95479	5	6	9
19	2x53	Shared	10.68	6.213	4	5	6
20	E1x50	Shared	8.985	8.35	6	5	8
21	E1x52	Shared	9.7925	5.59354	4	6	6
22	3x36	Shared	8.56	5.48312	4	4	7
23	3x37	Shared	6.71	4.57875	5	5	6
24	3x51	Shared	4.96	5.838	6	5	8
25	4x50	Shared	5.865	7.76813	4	4	9
26	E2	Shared	21.7164	10.5012	11	14	3
27	6x30	Shared	6.7725	5.43675	4	5	6
28	6x48	Shared	10.7283	8.34875	6	5	8
29	6x51	Shared	7.376	5.85825	5	5	6
30	6x52	Shared	10.122	6.62281	5	4	7
31	7x42	Shared	6.11167	7.49425	6	5	7
32	7x53	Shared	6.716	6.578	5	5	9
33	8x50	Shared	8.474	3.2575	5	6	8
34	2x41	somatostatin_on	2.61667	3.23969	3	4	5
35	2x46	somatostatin_on	2.75	3.51437	2	4	9
36	2x57	somatostatin_on	4.09333	4.195	3	5	7
37	3x32	somatostatin_on	7.21	5.07375	3	5	6
38	3x34	somatostatin_on	4.57667	4.27531	3	4	5
39	3x56	somatostatin_on	7.025	4.90281	2	4	5
40	I2x57	somatostatin_on	8.36	4.27575	3	5	5
41	4x38	somatostatin_on	8.085	1.69156	2	4	6
42	4x61	somatostatin_on	4.56	3.64031	2	4	3
43	E2x52	somatostatin_on	10.1867	4.16375	3	4	5
44	5x40	somatostatin_on	4.01667	2.55437	3	4	5
45	5x50	somatostatin_on	6.885	2.75406	2	4	9
46	5x58	somatostatin_on	8.9	5.52982	2	7	9
47	5x62	somatostatin_on	0	2.00281	0	4	5
48	I3	somatostatin_on	0	3.42031	0	4	0
49	6x26	somatostatin_on	11.9	5.36719	3	4	4
50	6x40	somatostatin_on	5.96	6.68937	1	4	8
51	6x49	somatostatin_on	5.91333	3.50562	3	4	5
52	7x39	somatostatin_on	2.795	4.65281	2	4	5
53	7x49	somatostatin_on	3.83	3.9435	3	5	9

Orange: nodes, hubs and links specific of somatostatin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of somatostatin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	somatostatin_off Recurrence	somatostatin_on Recurrence	somatostatin_off Hub1?	somatostatin_on Hub1?	somatostatin_off Hub2?	somatostatin_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	somatostatin_off	10.1825	1.64625	Yes	Yes	No	No	7	6
2	3x32	7x42	somatostatin_off	14.0115	0.500177	No	Yes	Yes	Yes	6	7
3	3x32	Lig	somatostatin_off	74.165	7.2506	No	Yes	Yes	Yes	6	0
4	2x54	2x57	somatostatin_off	26.6502	6.54956	No	No	No	Yes	6	7
5	1x47	2x54	somatostatin_off	24.3097	0	No	No	No	No	6	6
6	1x47	2x51	somatostatin_off	23.3314	1.98889	No	No	No	No	6	7
7	2x50	3x35	somatostatin_off	98.3222	0	Yes	Yes	No	No	9	7
8	2x53	3x35	somatostatin_off	100	8.34548	Yes	Yes	No	No	6	7
9	2x53	3x32	somatostatin_off	60.3534	8.22732	Yes	Yes	No	Yes	6	6
10	1x60	8x53	somatostatin_off	21.2276	9.33795	Yes	No	No	No	6	5
11	8x53	I1x50	somatostatin_off	27.4549	0	No	No	Yes	No	5	7
12	8x50	I1x50	somatostatin_off	31.4785	0	Yes	Yes	Yes	No	8	7
13	7x53	8x50	somatostatin_off	43.3125	0	Yes	Yes	Yes	Yes	9	8
14	1x54	2x44	somatostatin_off	22.9527	0	Yes	No	No	No	7	6
15	1x54	2x51	somatostatin_off	22.4373	0	Yes	No	No	No	7	7
16	3x50	6x37	somatostatin_off	50.5496	0	Yes	No	No	No	9	8
17	3x46	6x37	somatostatin_off	51.8961	0	No	No	No	No	9	8
18	2x43	3x46	somatostatin_off	70.415	0	No	No	No	No	8	9
19	2x43	7x53	somatostatin_off	71.5773	0	No	No	Yes	Yes	8	9
20	2x41	4x42	somatostatin_off	10.8189	2.06372	No	Yes	No	No	5	7
21	2x42	4x42	somatostatin_off	12.2758	0	Yes	Yes	No	No	7	7
22	2x44	2x45	somatostatin_off	20.0284	0	No	No	No	No	6	9
23	2x59	E1x52	somatostatin_off	18.4295	5.58859	No	No	Yes	Yes	5	6
24	E2	E2x51	somatostatin_off	20.7595	0	Yes	Yes	No	No	3	4
25	E2x51	Lig	somatostatin_off	21.7272	1.52416	No	No	Yes	Yes	4	0
26	E2	E2x52	somatostatin_off	21.7062	4.22591	Yes	Yes	No	Yes	3	5
27	3x29	E2x50	somatostatin_off	12.1443	0	No	No	No	No	5	9
28	3x29	Lig	somatostatin_off	15.5736	1.49659	No	No	Yes	Yes	5	0
29	3x36	6x52	somatostatin_off	23.0895	0	Yes	Yes	Yes	Yes	7	7
30	5x51	5x54	somatostatin_off	16.373	0	No	No	Yes	No	6	7
31	5x47	5x51	somatostatin_off	21.7483	0	No	No	No	No	8	6
32	5x47	6x52	somatostatin_off	37.6216	8.41637	No	No	Yes	Yes	8	7
33	3x50	6x34	somatostatin_off	42.1501	0	Yes	No	No	No	9	7
34	3x51	5x61	somatostatin_off	26.0822	0	Yes	Yes	No	No	8	9
35	3x54	5x61	somatostatin_off	27.4917	2.07948	No	No	No	No	8	9
36	3x54	6x30	somatostatin_off	29.017	0	No	No	Yes	Yes	8	6
37	6x30	6x34	somatostatin_off	40.7405	0	Yes	Yes	No	No	6	7
38	5x36	Lig	somatostatin_off	14.3691	3.07983	Yes	No	Yes	Yes	4	0
39	5x44	6x52	somatostatin_off	10.9557	6.48261	No	No	Yes	Yes	5	7
40	5x47	6x49	somatostatin_off	13.6696	6.42354	No	No	No	Yes	8	5
41	7x41	7x42	somatostatin_off	43.3388	0	No	No	Yes	Yes	7	7
42	1x53	7x53	somatostatin_off	14.7162	0	No	No	Yes	Yes	9	9
43	1x53	2x47	somatostatin_off	13.3382	0	No	No	No	No	9	9
44	1x54	2x47	somatostatin_off	13.5171	2.06372	Yes	No	No	No	7	9
45	1x39	7x42	somatostatin_off	15.7103	0	Yes	Yes	Yes	Yes	7	7
46	6x48	6x52	somatostatin_off	15.0844	0	Yes	Yes	Yes	Yes	8	7
47	2x57	7x42	Shared	31.8256	45.3743	No	Yes	Yes	Yes	7	7
48	7x49	7x53	Shared	94.8877	100	No	Yes	Yes	Yes	9	9
49	2x50	7x49	Shared	94.914	25.6587	Yes	Yes	No	Yes	9	9
50	2x42	3x46	Shared	20.0494	31.8893	Yes	Yes	No	No	7	9
51	2x45	4x50	Shared	15.563	28.8567	No	No	Yes	Yes	9	9
52	E1x50	E1x52	Shared	19.6708	16.624	Yes	Yes	Yes	Yes	8	6
53	E1x50	E2	Shared	20.2598	10.9054	Yes	Yes	Yes	Yes	8	3
54	E2x52	Lig	Shared	23.6943	11.2953	No	Yes	Yes	Yes	5	0
55	3x36	3x37	Shared	20.6753	20.5782	Yes	Yes	Yes	Yes	7	6
56	3x36	Lig	Shared	45.5951	51.9948	Yes	Yes	Yes	Yes	7	0
57	3x36	6x48	Shared	12.1654	49.167	Yes	Yes	Yes	Yes	7	8
58	6x51	6x52	Shared	15.5946	10.1886	Yes	Yes	Yes	Yes	6	7
59	6x48	7x41	Shared	26.8553	10.2556	Yes	Yes	No	No	8	7
60	2x53	7x42	Shared	41.0614	31.7475	Yes	Yes	Yes	Yes	6	7
61	6x51	7x41	Shared	16.0364	10.0114	Yes	Yes	No	No	6	7
62	1x39	2x57	somatostatin_on	0	35.2566	Yes	Yes	No	Yes	7	7
63	7x42	Lig	somatostatin_on	0	24.0203	Yes	Yes	Yes	Yes	7	0
64	E2	Lig	somatostatin_on	0	27.1238	Yes	Yes	Yes	Yes	3	0
65	1x38	7x39	somatostatin_on	3.20307	12.4966	No	No	No	Yes	5	5
66	1x39	7x39	somatostatin_on	4.79146	18.798	Yes	Yes	No	Yes	7	5
67	2x50	7x46	somatostatin_on	0.578552	36.954	Yes	Yes	No	No	9	8
68	2x53	7x46	somatostatin_on	0	37.6511	Yes	Yes	No	No	6	8
69	2x53	3x36	somatostatin_on	0	12.1027	Yes	Yes	Yes	Yes	6	7
70	2x44	I1x50	somatostatin_on	0	42.9128	No	No	Yes	No	6	7
71	2x41	I1x50	somatostatin_on	0	44.7363	No	Yes	Yes	No	5	7
72	2x41	4x46	somatostatin_on	0	50.4431	No	Yes	No	No	5	7
73	2x45	4x46	somatostatin_on	3.19255	52.2981	No	No	No	No	9	7
74	3x34	4x50	somatostatin_on	4.69679	28.3329	No	Yes	Yes	Yes	5	9
75	3x34	4x57	somatostatin_on	0	31.8499	No	Yes	No	No	5	7
76	4x57	4x61	somatostatin_on	0	17.2187	No	No	No	Yes	7	3
77	4x61	E2x52	somatostatin_on	2.98217	13.619	No	Yes	No	Yes	3	5
78	1x56	8x50	somatostatin_on	0	12.9534	No	No	Yes	Yes	7	8
79	1x57	8x50	somatostatin_on	1.54105	31.4206	No	No	Yes	Yes	7	8
80	1x57	2x44	somatostatin_on	0	33.3701	No	No	No	No	7	6
81	2x37	I2x57	somatostatin_on	0	14.513	No	No	No	Yes	7	5
82	3x49	I2x57	somatostatin_on	5.86967	26.4031	No	No	No	Yes	8	5
83	2x42	3x49	somatostatin_on	0	27.5413	Yes	Yes	No	No	7	8
84	3x46	3x50	somatostatin_on	0	32.992	No	No	Yes	No	9	9
85	3x50	7x53	somatostatin_on	0	72.0846	Yes	No	Yes	Yes	9	9
86	7x45	7x49	somatostatin_on	0	60.5175	Yes	No	No	Yes	9	9
87	6x48	7x45	somatostatin_on	8.30484	61.0137	Yes	Yes	Yes	No	8	9
88	2x37	2x40	somatostatin_on	1.68832	12.0555	No	No	Yes	Yes	7	8
89	2x46	7x49	somatostatin_on	0.557513	23.0633	No	Yes	No	Yes	9	9
90	2x46	3x42	somatostatin_on	0	48.5999	No	Yes	No	No	9	8
91	2x45	3x42	somatostatin_on	0	46.7488	No	No	No	No	9	8
92	3x37	5x43	somatostatin_on	0	12.0633	Yes	Yes	No	No	6	4
93	5x43	Lig	somatostatin_on	0	14.4264	No	No	Yes	Yes	4	0
94	3x47	5x58	somatostatin_on	5.49624	31.0386	No	No	No	Yes	9	9
95	3x50	5x58	somatostatin_on	0	48.8401	Yes	No	No	Yes	9	9
96	5x58	6x40	somatostatin_on	0	44.5276	No	Yes	No	Yes	9	8
97	6x40	7x53	somatostatin_on	0	46.5677	No	Yes	Yes	Yes	8	9
98	3x51	5x57	somatostatin_on	5.09125	24.4772	Yes	Yes	No	No	8	7
99	3x47	5x57	somatostatin_on	0	28.8961	No	No	No	No	9	7
100	5x40	6x55	somatostatin_on	0	18.3963	No	Yes	No	No	5	6
101	6x55	Lig	somatostatin_on	0	14.7257	No	No	Yes	Yes	6	0
102	5x40	6x59	somatostatin_on	4.50744	11.5553	No	Yes	No	No	5	4
103	5x58	6x37	somatostatin_on	0	53.2236	No	Yes	No	No	9	8
104	5x62	6x37	somatostatin_on	0	51.089	No	Yes	No	No	5	8
105	5x62	6x30	somatostatin_on	0	40.3962	No	Yes	Yes	Yes	5	6
106	6x26	6x30	somatostatin_on	8.27855	15.0289	No	Yes	Yes	Yes	4	6
107	7x55	8x50	somatostatin_on	0	10.2398	No	No	Yes	Yes	7	8
108	1x56	8x53	somatostatin_on	5.09125	10.9291	No	No	No	No	7	5
109	6x27	6x30	somatostatin_on	3.40294	11.0236	No	No	Yes	Yes	3	6
110	3x37	4x57	somatostatin_on	8.37322	20.8066	Yes	Yes	No	No	6	7
111	2x46	3x43	somatostatin_on	0	20.1095	No	Yes	No	No	9	9
112	3x43	7x53	somatostatin_on	0	20.1883	No	No	Yes	Yes	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
5x36	Lig	Shared	23.28	6.775	1	1	1	0
6x54	Lig	somatostatin_off	9.52	0	1	0	1	0
6x61	Lig	somatostatin_off	4.42	0	0	0	1	0
E3	Lig	Shared	14.37	3.41375	1	1	1	0
7x30	Lig	somatostatin_off	5.41	0	1	0	1	0
7x31	Lig	Shared	14.25	2.595	1	0	1	0
7x34	Lig	Shared	17.11	11.6425	1	1	1	0
3x29	Lig	Shared	5.61	3.29625	1	0	1	0
E2x51	Lig	Shared	8.19	11.4025	1	0	1	0
E2x52	Lig	Shared	7.93	4.4675	1	1	1	0
3x32	Lig	Shared	11.06	10.2375	1	1	1	0
3x36	Lig	Shared	8.14	8.17125	1	1	1	0
2x64	Lig	somatostatin_off	7.94	0	1	0	1	0
7x35	Lig	somatostatin_off	15.52	0	1	0	1	0
1x32	Lig	somatostatin_off	16.79	0	1	0	1	0
E1	Lig	somatostatin_off	13.88	0	1	0	1	0
1x30	1x32	somatostatin_off	8.77	0	0	0	2	1
1x32	2x64	somatostatin_off	4.43	0	1	0	1	1
1x32	E1	somatostatin_off	10.52	0	1	0	1	1
1x35	1x39	Shared	8.21	2.86625	1	0	2	2
1x35	2x64	somatostatin_off	4.47	0	1	0	2	1
1x35	7x35	Shared	6.79	4.3725	1	0	2	1
1x39	2x64	somatostatin_off	5.05	0	1	0	2	1
1x39	7x42	somatostatin_off	4.96	0	1	0	2	1
2x53	3x32	Shared	5.97	4.62875	1	1	2	1
2x53	7x42	Shared	12.38	14.7	1	1	2	1
2x57	7x42	Shared	4.69	8.01125	0	0	2	1
2x60	3x28	somatostatin_off	4.47	0	0	0	1	2
2x63	E1x50	Shared	10.95	5.82625	0	1	1	2
E1x49	E2	Shared	11.22	6.95	1	1	2	1
3x25	E1x50	Shared	3.92	8.32625	1	1	2	2
E1x50	E2	Shared	6.93	3.07375	1	1	2	1
E1x50	E2x50	Shared	18.28	8.49	1	1	2	2
3x22	E2	Shared	5.23	5.27625	0	1	2	1
3x25	E2x50	Shared	7.28	6.825	1	1	2	2
3x29	E2x50	somatostatin_off	4.86	0	1	0	1	2
3x32	7x42	Shared	4.6	5.46	1	1	1	1
3x36	3x37	Shared	10.54	3.77	1	1	1	2
3x36	6x48	Shared	7.67	6.6075	1	1	1	2
3x36	6x52	somatostatin_off	7.89	0	1	1	1	2
4x61	E2x52	Shared	7.36	5.02875	0	0	2	1
4x64	E2	Shared	23.02	17.5725	1	1	2	1
E2	E2	Shared	55.97	36.53	1	1	1	1
E2	E2x51	somatostatin_off	5.81	0	1	1	1	1
E2	E2x52	Shared	15.27	5.34375	1	1	1	1
5x35	E2	Shared	38.4	9.37375	0	1	2	1
5x39	E2	Shared	15.03	8.64625	1	1	2	1
5x34	E2	somatostatin_off	6.03	0	0	0	2	1
5x36	5x40	somatostatin_off	6.04	0	1	1	1	2
5x36	6x58	somatostatin_off	5.09	0	1	1	1	1
5x39	5x43	somatostatin_off	7.78	0	1	1	2	1
6x48	6x51	somatostatin_off	5.01	0	1	1	2	1
6x48	6x52	somatostatin_off	8.68	0	1	1	2	2
6x48	7x41	Shared	18.19	7.9525	1	1	2	2
6x51	6x52	Shared	8.25	3.73875	1	1	1	2
6x51	6x55	Shared	14.5	8.68625	1	1	1	1
6x51	7x37	somatostatin_off	3.93	0	1	1	1	2
6x51	7x41	Shared	5.19	4.60375	1	1	1	2
6x54	7x33	somatostatin_off	9.95	0	1	0	1	2
6x54	7x34	Shared	13.93	3.655	1	0	1	1
7x31	E3	somatostatin_off	6.69	0	1	0	1	1
7x27	7x30	Shared	5.9	2.94875	0	0	2	1
7x34	7x38	Shared	7.87	3.9775	1	1	1	2
7x38	7x42	Shared	5.05	4.7325	0	0	2	1
7x41	7x42	somatostatin_off	4.99	0	1	0	2	1
1x31	Lig	somatostatin_off	3.72	0	0	0	1	0
3x29	4x65	somatostatin_off	3.22	0	1	0	1	2
1x36	2x64	somatostatin_off	3.17	0	0	0	2	1
3x33	4x61	somatostatin_off	1.76	0	0	0	2	2
7x31	7x32	somatostatin_off	1.74	0	1	0	1	2
5x33	5x36	somatostatin_off	1.45	0	0	0	2	1
E2	Lig	somatostatin_on	0	4.9225	1	1	1	0
5x43	Lig	somatostatin_on	0	5.575	0	1	1	0
6x51	Lig	somatostatin_on	0	8.8425	1	1	1	0
7x42	Lig	somatostatin_on	0	4.5675	1	1	1	0
2x63	Lig	somatostatin_on	0	4.19125	0	1	1	0
2x53	3x36	somatostatin_on	0	3.38375	1	1	2	1
2x64	7x35	somatostatin_on	0	5.48	1	0	1	1
3x25	E2	somatostatin_on	0	3.12375	1	1	2	1
3x37	5x43	somatostatin_on	0	3.24125	0	0	2	1
4x61	5x39	somatostatin_on	0	4.0825	0	0	2	2
E2	E2x50	somatostatin_on	0	3.355	1	1	1	2
5x36	E2	somatostatin_on	0	4.38625	1	1	1	1
5x40	6x55	somatostatin_on	0	3.5475	0	0	2	1
5x43	6x52	somatostatin_on	0	3.2775	0	1	1	2
6x51	7x38	somatostatin_on	0	3.42	1	1	1	2
6x55	Lig	somatostatin_on	0	9.66	0	1	1	0
2x60	Lig	somatostatin_on	0	8.1525	0	0	1	0
6x54	7x37	somatostatin_on	0	4.04	1	0	1	2
2x56	3x32	somatostatin_on	0	2.945	0	0	2	1
1x36	1x39	somatostatin_on	0	2.8175	0	0	2	2
1x39	2x57	somatostatin_on	0	2.78375	1	0	2	2
1x32	1x35	somatostatin_on	0	2.7025	1	0	1	2
6x58	Lig	somatostatin_on	0	2.66125	0	0	1	0
7x33	E3	somatostatin_on	0	2.57	0	0	2	1
6x54	6x57	somatostatin_on	0	2.4375	1	0	1	2
3x32	3x33	somatostatin_on	0	2.0975	1	1	1	2
E1	E2	somatostatin_on	0	1.9325	1	0	1	1
4x65	E2x52	somatostatin_on	0	1.815	0	0	2	1
6x60	6x61	somatostatin_on	0	1.67	0	0	2	1
7x32	7x35	somatostatin_on	0	1.2575	0	0	2	1
1x29	1x31	somatostatin_on	0	1.12625	0	0	2	1
7x30	E3	somatostatin_on	0	1.07125	1	0	1	1
1x29	1x30	somatostatin_on	0	0.92125	0	0	2	2
5x34	5x36	somatostatin_on	0	0.5	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	somatostatin_off	sst2_off
	somatostatin_on	sst2_on sst4_on sst5_on

Network Difference
Value	somatostatin_off	somatostatin_on
I_min	3.92	2.95625
Number of Linked Nodes	253	266
Number of Specific Nodes	5 (1.98%)	18 (6.77%)
Number of Shared Nodes	248 (98.02%)	248 (93.23%)
Number of Links	283	302
Number of Specific Links	139 (49.12%)	158 (52.32%)
Number of Shared Links	144 (50.88%)	144 (47.68%)
Number of Hubs	33	40
Number of Specific Hubs	13 (39.39%)	20 (50.00%)
Number of Shared Hubs	20 (60.61%)	20 (50.00%)
Average % Shared Neighbours (Jaccard)	33.45
Average % Shared Neighbours (Otsuka)	42.79
Average % Shared Neighbours (Overlap Coefficient)	52.05
Average % Shared Cliques (k3-6)	52.70
Graphlets Similarity	0.634544

Paths Difference
Value	somatostatin_off	somatostatin_on
Number Of Nodes in MetaPath	56	60
Specific Nodes in MetaPath	25 (44.64%)	29 (48.33%)
Shared Nodes in MetaPath	248 (98.02%)	248 (98.02%)
Number Of Links MetaPath	61	66
Specific Links in MetaPath	46 (75.41%)	51 (77.27%)
Shared Links in MetaPath	144 (50.88%)	144 (50.88%)
Number of Shortest Paths	42908	63034
Length Of Smallest Path	3	3
Average Path Length	12.4996	12.2241
Length of Longest Path	29	30
Minimum Path Strength	1.44	0.486875
Average Path Strength	7.77815	5.40146
Maximum Path Strength	30.71	13.4731
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.923966	0.908709
Maximum Path Correlation	1	0.985
Minimum % Of Corr. Nodes	5	3.84615
Average % Of Corr. Nodes	53.5341	43.8435
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.7797	50.8781
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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