Orange: nodes, hubs and links specific of somatostatin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of somatostatin_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner somatostatin_on_gp Avg Int. Strength somatostatin_off Avg Int. Strength somatostatin_on_gp Num Of Links somatostatin_off Num Of Links ConSurf
12x37 somatostatin_on_gp3.1721913.16417
22x41 somatostatin_on_gp3.239692.61667435
32x46 somatostatin_on_gp3.514372.75429
42x57 somatostatin_on_gp4.1954.09333537
53x32 somatostatin_on_gp5.073757.21536
63x34 somatostatin_on_gp4.275314.57667435
7I2x57 somatostatin_on_gp5.2158.36435
84x38 somatostatin_on_gp3.7328.085526
94x61 somatostatin_on_gp3.640314.56423
10E2x52 somatostatin_on_gp4.1637510.1867435
115x40 somatostatin_on_gp2.554374.01667435
125x50 somatostatin_on_gp2.754066.885429
135x58 somatostatin_on_gp6.174178.9629
14I3 somatostatin_on_gp4.365420603
156x26 somatostatin_on_gp5.3671911.9434
166x40 somatostatin_on_gp6.689375.96418
176x49 somatostatin_on_gp3.505625.91333435
186x54 somatostatin_on_gp3.1815611.1333434
196x59 somatostatin_on_gp2.719374.73667434
20E3 somatostatin_on_gp2.4128110.53422
217x35 somatostatin_on_gp3.4737511.155422
227x39 somatostatin_on_gp4.652812.795425
237x49 somatostatin_on_gp3.727713.83639
247x50 somatostatin_on_gp4.308756.915429
25G.HN.45 somatostatin_on_gp3.419690404
26G.S1.01 somatostatin_on_gp5.697810406
27G.S1.02 somatostatin_on_gp5.209250505
28G.S1.04 somatostatin_on_gp3.3950407
29G.S1.06 somatostatin_on_gp3.8320508
30G.H1.01 somatostatin_on_gp3.883250509
31G.H1.07 somatostatin_on_gp3.050940409
32G.H1.08 somatostatin_on_gp4.803440408
33G.S2.03 somatostatin_on_gp6.163130409
34G.S2.08 somatostatin_on_gp5.747810405
35G.S3.01 somatostatin_on_gp4.60404
36G.S3.02 somatostatin_on_gp5.0550404
37G.S3.03 somatostatin_on_gp6.670210607
38G.S3.04 somatostatin_on_gp7.366250506
39G.S3.05 somatostatin_on_gp4.220250507
40G.S3.06 somatostatin_on_gp9.427190405
41G.S3.07 somatostatin_on_gp3.585940409
42G.H2.02 somatostatin_on_gp4.084690408
43G.H2.03 somatostatin_on_gp4.242810409
44G.H2.06 somatostatin_on_gp4.9550809
45G.H2.07 somatostatin_on_gp4.061070709
46G.H2.09 somatostatin_on_gp6.514060408
47G.H2.10 somatostatin_on_gp3.740310407
48G.S4.02 somatostatin_on_gp4.260620408
49G.S4.04 somatostatin_on_gp5.701560409
50G.s4h3.04 somatostatin_on_gp5.988540608
51G.H3.09 somatostatin_on_gp5.381670609
52G.H3.13 somatostatin_on_gp3.409380405
53G.H3.17 somatostatin_on_gp8.2350505
54G.H3.18 somatostatin_on_gp5.643750409
55G.S5.02 somatostatin_on_gp3.599060406
56G.S5.03 somatostatin_on_gp3.27650508
57G.S5.05 somatostatin_on_gp3.89650509
58G.S5.07 somatostatin_on_gp3.16850509
59G.HG.02 somatostatin_on_gp2.624060409
60G.HG.04 somatostatin_on_gp4.806750509
61G.HG.14 somatostatin_on_gp2.319690405
62G.hgh4.01 somatostatin_on_gp3.56050506
63G.hgh4.02 somatostatin_on_gp5.277080607
64G.H4.03 somatostatin_on_gp6.34950504
65G.H4.15 somatostatin_on_gp3.976250408
66G.S6.02 somatostatin_on_gp6.4450707
67G.H5.08 somatostatin_on_gp5.187250508
68G.H5.26 somatostatin_on_gp3.8850605
69b.1x4 somatostatin_on_gp1.398120408
70b.1x11 somatostatin_on_gp1.402810408
71b.1x15 somatostatin_on_gp1.878120407
72b.1x19 somatostatin_on_gp4.895310406
73b.h2x1 somatostatin_on_gp3.232810405
74b.h2x5 somatostatin_on_gp3.81550505
75b.b1x4 somatostatin_on_gp3.766880407
76b.l1x3 somatostatin_on_gp7.510830609
77b.b2x1 somatostatin_on_gp8.126750508
78b.b2x5 somatostatin_on_gp7.087920607
79b.b3x3 somatostatin_on_gp3.43950508
80b.l3x2 somatostatin_on_gp4.3920509
81b.b4x2 somatostatin_on_gp5.346870408
82b.b4x3 somatostatin_on_gp4.498440407
83b.b4x4 somatostatin_on_gp8.048440408
84b.b4x5 somatostatin_on_gp4.100940407
85b.b4x6 somatostatin_on_gp8.25250709
86b.l4x2 somatostatin_on_gp10.55560404
87b.b5x2 somatostatin_on_gp5.776250407
88b.b5x3 somatostatin_on_gp6.365420609
89b.b5x5 somatostatin_on_gp4.876870405
90b.b5x7 somatostatin_on_gp6.670940407
91b.l5x1 somatostatin_on_gp3.85950508
92b.l5x5 somatostatin_on_gp8.126250609
93b.b6x5 somatostatin_on_gp3.827710606
94b.l6x5 somatostatin_on_gp6.247810404
95b.b7x1 somatostatin_on_gp5.414250504
96b.b8x3 somatostatin_on_gp3.380620406
97b.b8x4 somatostatin_on_gp4.643130606
98b.l8x5 somatostatin_on_gp5.433130403
99b.l8x8 somatostatin_on_gp4.906250404
100b.l9x3 somatostatin_on_gp6.142290609
101b.l9x6 somatostatin_on_gp5.127860708
102b.l9x7 somatostatin_on_gp3.425630407
103b.b10x5 somatostatin_on_gp4.138960609
104b.l10x1 somatostatin_on_gp3.739060403
105b.b11x4 somatostatin_on_gp3.68650509
106b.b11x6 somatostatin_on_gp6.848120409
107b.l11x2 somatostatin_on_gp5.715420609
108b.b12x3 somatostatin_on_gp3.317190408
109b.b12x6 somatostatin_on_gp8.562290608
110b.b13x7 somatostatin_on_gp7.25250507
111b.l13x3 somatostatin_on_gp7.324750509
112b.l13x6 somatostatin_on_gp4.9820509
113b.b14x1 somatostatin_on_gp5.090630408
114b.b14x3 somatostatin_on_gp4.625630405
115b.b15x2 somatostatin_on_gp6.595310406
116b.b15x3 somatostatin_on_gp3.59750409
117b.l15x1 somatostatin_on_gp4.59350507
118b.l15x2 somatostatin_on_gp5.844690409
119b.b16x4 somatostatin_on_gp7.8910506
120b.b16x5 somatostatin_on_gp4.310405
121b.b16x6 somatostatin_on_gp9.031670608
122b.b17x7 somatostatin_on_gp6.122750508
123b.l17x3 somatostatin_on_gp7.453570709
124b.l17x7 somatostatin_on_gp3.743750407
125b.b18x3 somatostatin_on_gp4.355750508
126b.b18x5 somatostatin_on_gp4.4980505
127b.l18x1 somatostatin_on_gp5.649640706
128b.l18x2 somatostatin_on_gp5.271870407
129b.b19x2 somatostatin_on_gp6.288040706
130b.b19x4 somatostatin_on_gp5.31950508
131b.l19x2 somatostatin_on_gp6.108750509
132b.b20x4 somatostatin_on_gp8.065420608
133b.b20x6 somatostatin_on_gp6.372290606
134b.b21x1 somatostatin_on_gp7.307810407
135b.b21x4 somatostatin_on_gp4.306560405
136b.b21x7 somatostatin_on_gp5.8850605
137b.b22x5 somatostatin_on_gp5.48750507
138b.l22x5 somatostatin_on_gp7.3350409
139b.b23x3 somatostatin_on_gp3.598440407
140b.b23x6 somatostatin_on_gp7.175620607
141b.l23x1 somatostatin_on_gp7.082810406
142b.b24x4 somatostatin_on_gp6.490630406
143b.b24x6 somatostatin_on_gp6.426250408
144b.b24x7 somatostatin_on_gp6.088440409
145b.l24x2 somatostatin_on_gp4.342190406
146b.l24x3 somatostatin_on_gp4.041250405
147b.b25x3 somatostatin_on_gp4.5780505
148b.l25x3 somatostatin_on_gp8.587250509
149b.l25x6 somatostatin_on_gp11.22090408
150b.b26x3 somatostatin_on_gp3.792810406
151b.l27x1 somatostatin_on_gp11.35230709
152b.l27x2 somatostatin_on_gp7.853750409
153b.b28x3 somatostatin_on_gp3.735310407
154b.b28x4 somatostatin_on_gp6.47850506
155b.b28x6 somatostatin_on_gp11.81030409
156g.h1x11 somatostatin_on_gp1.357190409
157g.l1x4 somatostatin_on_gp4.027190408
158g.h2x11 somatostatin_on_gp9.486560406
159g.ctx3 somatostatin_on_gp5.742920609
160g.ctx5 somatostatin_on_gp3.214690409
161g.ctx6 somatostatin_on_gp3.34750406
162g.ctx15 somatostatin_on_gp5.884370409
163g.ctx16 somatostatin_on_gp4.396560808
164Lig Shared8.2812524.670520190
1651x39 Shared3.752924.948657
1662x40 Shared3.55557.9175548
1672x42 Shared5.83655.8975547
1682x50 Shared4.954796.178659
1692x53 Shared6.21310.68546
170E1x50 Shared8.358.985568
171E1x52 Shared5.593549.7925646
1723x36 Shared5.483128.56447
1733x37 Shared4.578756.71556
1743x50 Shared7.0346.142559
1753x51 Shared5.8384.96568
1764x50 Shared6.73155.865549
177E2 Shared9.5362521.716416113
1785x36 Shared3.600318.965444
1796x30 Shared5.436756.7725546
1806x48 Shared8.3487510.7283568
1816x51 Shared5.858257.376556
1826x52 Shared6.6228110.122457
1837x42 Shared6.710836.11167667
1847x53 Shared6.5786.716559
1858x50 Shared3.25758.474658
1861x32 somatostatin_off2.702510.1275143
1871x54 somatostatin_off2.495834.7225347
1881x60 somatostatin_off3.212927.985346
189I1x50 somatostatin_off3.179177.565347
1902x64 somatostatin_off5.485.012154
1913x38 somatostatin_off8.596256.388357
1924x56 somatostatin_off5.48255.39244
1935x54 somatostatin_off7.421254.9025247
1946x44 somatostatin_off6.0183310.7125349
1957x45 somatostatin_off8.128756.3975349
1968x57 somatostatin_off0.90753.385245
   
Orange: nodes, hubs and links specific of somatostatin_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of somatostatin_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner somatostatin_on_gp Recurrence somatostatin_off Recurrence somatostatin_on_gp Hub1? somatostatin_off Hub1? somatostatin_on_gp Hub2? somatostatin_off Hub2? ConSurf1 ConSurf2
12x50 7x46 somatostatin_on_gp10.71940.578552YesYesNoNo98
22x53 7x46 somatostatin_on_gp10.47940YesYesNoNo68
32x44 I1x50 somatostatin_on_gp11.53030NoNoNoYes67
42x41 I1x50 somatostatin_on_gp12.03510YesNoNoYes57
52x41 4x46 somatostatin_on_gp13.55170YesNoNoNo57
67x45 7x49 somatostatin_on_gp27.87480NoYesYesNo99
76x48 7x45 somatostatin_on_gp26.41068.30484YesYesNoYes89
83x49 I2x57 somatostatin_on_gp10.06055.86967NoNoYesNo85
92x42 3x49 somatostatin_on_gp10.31090YesYesNoNo78
103x46 3x50 somatostatin_on_gp11.56860NoNoYesYes99
113x50 7x53 somatostatin_on_gp63.44070YesYesYesYes99
122x46 7x49 somatostatin_on_gp10.11770.557513YesNoYesNo99
132x46 3x42 somatostatin_on_gp19.76160YesNoNoNo98
142x45 3x42 somatostatin_on_gp19.26120NoNoNoNo98
153x50 G.H5.25 somatostatin_on_gp76.71940YesYesNoNo97
16G.H5.20 G.H5.25 somatostatin_on_gp76.95650NoNoNoNo97
17G.H5.20 G.H5.26 somatostatin_on_gp77.66770NoNoYesNo95
18G.H5.17 G.H5.26 somatostatin_on_gp80.3890NoNoYesNo55
19G.H5.13 G.H5.17 somatostatin_on_gp81.00690NoNoNoNo85
20G.H5.13 G.S6.02 somatostatin_on_gp84.63920NoNoYesNo87
21G.S5.03 G.S6.02 somatostatin_on_gp46.94060YesNoYesNo87
22G.S5.03 G.S5.05 somatostatin_on_gp51.74630YesNoYesNo89
23G.S5.05 G.s6h5.01 somatostatin_on_gp98.81680YesNoNoNo99
24G.S5.07 G.s6h5.01 somatostatin_on_gp99.75920YesNoNoNo99
25G.S5.07 G.s4h3.02 somatostatin_on_gp99.90750YesNoNoNo99
26G.HG.07 G.s4h3.02 somatostatin_on_gp1000NoNoNoNo99
27G.HG.07 G.s4h3.04 somatostatin_on_gp99.88710NoNoYesNo98
28G.HG.04 G.s4h3.04 somatostatin_on_gp27.85490YesNoYesNo98
29G.HG.04 G.s4h3.01 somatostatin_on_gp28.17020YesNoNoNo97
30G.H4.11 G.s4h3.01 somatostatin_on_gp28.260NoNoNoNo77
31G.H4.11 G.H4.15 somatostatin_on_gp56.78540NoNoYesNo78
32G.H3.09 G.H4.15 somatostatin_on_gp53.72160YesNoYesNo98
33G.H3.09 G.S5.02 somatostatin_on_gp28.76560YesNoYesNo96
34G.S4.02 G.S5.02 somatostatin_on_gp28.64280YesNoYesNo86
35G.S1.05 G.S4.02 somatostatin_on_gp28.29660NoNoYesNo98
36G.S1.05 G.h2s4.01 somatostatin_on_gp28.08840NoNoNoNo99
37G.h2s4.01 b.l5x5 somatostatin_on_gp28.25180NoNoYesNo99
38b.l3x1 b.l5x5 somatostatin_on_gp21.18630NoNoYesNo99
39b.b2x1 b.l3x1 somatostatin_on_gp20.73710YesNoNoNo89
40b.b2x1 b.l27x1 somatostatin_on_gp21.80020YesNoYesNo89
41G.H5.06 G.S6.02 somatostatin_on_gp46.72060NoNoYesNo37
42G.H5.06 G.S5.05 somatostatin_on_gp46.76290NoNoYesNo39
43G.hgh4.01 G.s4h3.04 somatostatin_on_gp73.09890YesNoYesNo68
44G.hgh4.01 G.hgh4.02 somatostatin_on_gp74.46270YesNoYesNo67
45G.H4.11 G.hgh4.02 somatostatin_on_gp28.55060NoNoYesNo77
46G.H3.06 G.hgh4.02 somatostatin_on_gp46.6270NoNoYesNo67
47G.H3.06 G.H4.15 somatostatin_on_gp28.55670NoNoYesNo68
48G.H3.06 G.h4s6.01 somatostatin_on_gp18.10580NoNoNoNo64
49G.H3.09 G.h4s6.01 somatostatin_on_gp18.05210YesNoNoNo94
50G.H4.15 G.S4.06 somatostatin_on_gp31.58590YesNoNoNo87
51G.S4.04 G.S4.06 somatostatin_on_gp31.51290YesNoNoNo97
52G.H3.08 G.S4.04 somatostatin_on_gp73.75160NoNoYesNo99
53G.H2.04 G.H3.08 somatostatin_on_gp73.63720NoNoNoNo99
54G.H2.04 G.H2.07 somatostatin_on_gp73.53270NoNoYesNo99
55G.H2.07 b.l9x6 somatostatin_on_gp72.74070YesNoYesNo98
56b.l11x1 b.l9x6 somatostatin_on_gp46.81130NoNoYesNo98
57b.b11x6 b.l11x1 somatostatin_on_gp46.69470YesNoNoNo99
58G.H3.09 G.S4.04 somatostatin_on_gp41.98170YesNoYesNo99
59G.H2.06 b.l9x6 somatostatin_on_gp30.18460YesNoYesNo98
60G.H2.06 b.l19x1 somatostatin_on_gp29.15330YesNoNoNo99
61b.l25x6 b.l27x1 somatostatin_on_gp15.54330YesNoYesNo89
62b.l17x5 b.l19x1 somatostatin_on_gp28.98940NoNoNoNo69
63b.l17x5 b.l19x2 somatostatin_on_gp28.81270NoNoYesNo69
64b.l17x3 b.l19x2 somatostatin_on_gp26.28570YesNoYesNo99
65b.b20x6 b.l17x3 somatostatin_on_gp16.37480YesNoYesNo69
66b.b17x7 b.b20x6 somatostatin_on_gp10.25940YesNoYesNo86
67b.l23x1 b.l25x6 somatostatin_on_gp10.19010YesNoYesNo68
68b.b11x6 b.l9x3 somatostatin_on_gp23.16490YesNoYesNo99
69b.b11x4 b.l9x3 somatostatin_on_gp21.49390YesNoYesNo99
70b.b10x3 b.b11x4 somatostatin_on_gp35.24970NoNoYesNo89
71b.b10x3 b.b6x2 somatostatin_on_gp34.92050NoNoNoNo88
72b.b10x2 b.b6x2 somatostatin_on_gp34.59640NoNoNoNo68
73b.b11x6 b.l9x7 somatostatin_on_gp21.78810YesNoYesNo97
74b.b11x4 b.l9x7 somatostatin_on_gp21.45070YesNoYesNo97
75b.b10x2 b.b14x3 somatostatin_on_gp27.55090NoNoYesNo65
76b.b12x7 b.b13x4 somatostatin_on_gp13.80740NoNoNoNo94
77b.b13x5 b.b13x7 somatostatin_on_gp11.83010NoNoYesNo47
78b.b13x4 b.b13x5 somatostatin_on_gp10.47710NoNoNoNo44
79b.b14x3 b.b15x3 somatostatin_on_gp13.68790YesNoYesNo59
80b.b16x5 b.l14x6 somatostatin_on_gp10.82870YesNoNoNo53
812x45 4x46 somatostatin_on_gp13.80893.19255NoNoNoNo97
822x46 3x43 somatostatin_on_gp10.09750YesNoNoNo99
833x43 7x53 somatostatin_on_gp10.34260NoNoYesYes99
843x36 Lig Shared16.403545.5951YesYesYesYes70
853x36 6x48 Shared19.530212.1654YesYesYesYes78
862x42 3x46 Shared11.317320.0494YesYesNoNo79
877x49 7x53 Shared51.765694.8877YesNoYesYes99
882x50 7x49 Shared12.108294.914YesYesYesNo99
891x39 2x61 somatostatin_off0.25766410.1825YesYesNoNo76
903x32 7x42 somatostatin_off0.0033127814.0115YesNoYesYes67
913x32 Lig somatostatin_off0.054673574.165YesNoYesYes60
922x57 7x42 somatostatin_off7.6810231.8256YesNoYesYes77
932x54 2x57 somatostatin_off1.0304326.6502NoNoYesNo67
941x47 2x54 somatostatin_off024.3097NoNoNoNo66
951x47 2x51 somatostatin_off0.50526223.3314NoNoNoNo67
962x50 3x35 somatostatin_off098.3222YesYesNoNo97
972x53 3x35 somatostatin_off1.03326100YesYesNoNo67
982x53 3x32 somatostatin_off1.0320460.3534YesYesYesNo66
991x60 8x53 somatostatin_off2.4781421.2276NoYesNoNo65
1008x53 I1x50 somatostatin_off027.4549NoNoNoYes57
1018x50 I1x50 somatostatin_off031.4785YesYesNoYes87
1027x53 8x50 somatostatin_off043.3125YesYesYesYes98
1031x54 2x44 somatostatin_off022.9527NoYesNoNo76
1041x54 2x51 somatostatin_off022.4373NoYesNoNo77
1053x50 6x37 somatostatin_off050.5496YesYesNoNo98
1063x46 6x37 somatostatin_off051.8961NoNoNoNo98
1072x43 3x46 somatostatin_off070.415NoNoNoNo89
1082x43 7x53 somatostatin_off071.5773NoNoYesYes89
1092x41 4x42 somatostatin_off0.50655210.8189YesNoNoNo57
1102x42 4x42 somatostatin_off012.2758YesYesNoNo77
1112x44 2x45 somatostatin_off020.0284NoNoNoNo69
1122x45 4x50 somatostatin_off4.960815.563NoNoYesYes99
1132x59 E1x52 somatostatin_off1.0132818.4295NoNoYesYes56
114E1x50 E1x52 somatostatin_off3.0389319.6708YesYesYesYes86
115E1x50 E2 somatostatin_off1.7828120.2598YesYesYesYes83
116E2 E2x51 somatostatin_off0.003059920.7595YesYesNoNo34
117E2x51 Lig somatostatin_off0.25513521.7272NoNoYesYes40
118E2 E2x52 somatostatin_off0.035479621.7062YesYesYesNo35
119E2x52 Lig somatostatin_off1.3255423.6943YesNoYesYes50
1203x29 E2x50 somatostatin_off012.1443NoNoNoNo59
1213x29 Lig somatostatin_off0.25594415.5736NoNoYesYes50
1223x36 3x37 somatostatin_off3.1311820.6753YesYesYesYes76
1233x36 6x52 somatostatin_off023.0895YesYesYesYes77
1245x51 5x54 somatostatin_off016.373NoNoNoYes67
1255x47 5x51 somatostatin_off021.7483NoNoNoNo86
1265x47 6x52 somatostatin_off0.29984537.6216NoNoYesYes87
1273x50 6x34 somatostatin_off042.1501YesYesNoNo97
1283x51 5x61 somatostatin_off026.0822YesYesNoNo89
1293x54 5x61 somatostatin_off0.25349127.4917NoNoNoNo89
1303x54 6x30 somatostatin_off029.017NoNoYesYes86
1316x30 6x34 somatostatin_off040.7405YesYesNoNo67
1325x36 Lig somatostatin_off1.7843714.3691YesYesYesYes40
1335x44 6x52 somatostatin_off0.77425510.9557NoNoYesYes57
1345x47 6x49 somatostatin_off0.042838613.6696NoNoYesNo85
1356x51 6x52 somatostatin_off1.2878115.5946YesYesYesYes67
1366x48 7x41 somatostatin_off2.9803426.8553YesYesNoNo87
1377x41 7x42 somatostatin_off043.3388NoNoYesYes77
1381x53 7x53 somatostatin_off014.7162NoNoYesYes99
1391x53 2x47 somatostatin_off013.3382NoNoNoNo99
1401x54 2x47 somatostatin_off0.50655213.5171NoYesNoNo79
1411x39 7x42 somatostatin_off015.7103YesYesYesYes77
1422x53 7x42 somatostatin_off8.2664241.0614YesYesYesYes67
1436x51 7x41 somatostatin_off2.7336816.0364YesYesNoNo67
1446x48 6x52 somatostatin_off015.0844YesYesYesYes87

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
5x36LigShared23.286.7751210
6x54LigShared9.522.593751210
6x61Ligsomatostatin_off4.4200010
E3LigShared14.373.413751210
7x30Ligsomatostatin_off5.4101010
7x31LigShared14.252.5951010
7x34LigShared17.1111.64251210
3x29LigShared5.613.296251010
E2x51LigShared8.1911.40251210
E2x52LigShared7.934.46751210
3x32LigShared11.0610.23751210
3x36LigShared8.148.171251210
2x64Ligsomatostatin_off7.9401010
7x35Ligsomatostatin_off15.52012110
1x32Ligsomatostatin_off16.7901010
E1Ligsomatostatin_off13.8801010
1x301x32somatostatin_off8.7700021
1x322x64somatostatin_off4.4301011
1x32E1somatostatin_off10.5201011
1x351x39Shared8.212.8662512122
1x352x64somatostatin_off4.47012121
1x357x35Shared6.794.372512121
1x392x64somatostatin_off5.05012121
1x397x42somatostatin_off4.96012121
2x533x32Shared5.974.628751221
2x537x42Shared12.3814.71221
2x577x42Shared4.698.011250021
2x603x28somatostatin_off4.4700212
2x63E1x50Shared10.955.826250212
E1x49E2Shared11.226.951221
3x25E1x50Shared3.928.326251222
E1x50E2Shared6.933.073751221
E1x50E2x50Shared18.288.491222
3x22E2Shared5.235.276250221
3x25E2x50Shared7.286.8251222
3x29E2x50somatostatin_off4.8601012
3x327x42Shared4.65.461211
3x363x37Shared10.543.771212
3x366x48Shared7.676.60751212
3x366x52somatostatin_off7.8901212
4x61E2x52Shared7.365.028750021
4x64E2Shared23.0217.57251221
E2E2Shared55.9736.531211
E2E2x51Shared5.812.8251211
E2E2x52Shared15.275.343751211
5x35E2Shared38.49.373750221
5x39E2Shared15.038.646251221
5x34E2somatostatin_off6.0300021
5x365x40somatostatin_off6.0401212
5x366x58somatostatin_off5.0901211
5x395x43somatostatin_off7.7801221
6x486x51somatostatin_off5.0101221
6x486x52somatostatin_off8.6801222
6x487x41Shared18.197.95251222
6x516x52Shared8.253.738751212
6x516x55Shared14.58.686251211
6x517x37somatostatin_off3.9301212
6x517x41Shared5.194.603751212
6x547x33somatostatin_off9.9501212
6x547x34Shared13.933.6551211
7x31E3somatostatin_off6.6901011
7x277x30Shared5.92.948750021
7x347x38Shared7.873.97751212
7x387x42Shared5.054.73250021
7x417x42somatostatin_off4.9901021
1x31Ligsomatostatin_off3.7200010
3x294x65somatostatin_off3.2201012
1x362x64somatostatin_off3.1700021
5x406x59Shared3.073.43250022
5x325x33Shared1.860.99750222
3x334x61somatostatin_off1.7600022
7x317x32somatostatin_off1.7401012
6x596x60Shared1.622.13250022
5x335x36somatostatin_off1.4500021
E2Ligsomatostatin_on_gp04.92251210
6x58Ligsomatostatin_on_gp02.661250210
5x43Ligsomatostatin_on_gp05.5750210
6x51Ligsomatostatin_on_gp08.84251210
7x42Ligsomatostatin_on_gp04.56751210
2x63Ligsomatostatin_on_gp04.191250210
1x392x57somatostatin_on_gp02.7837512122
1x397x35somatostatin_on_gp02.78512121
2x533x36somatostatin_on_gp03.383751221
2x647x35somatostatin_on_gp05.481011
3x25E2somatostatin_on_gp03.123751221
3x375x43somatostatin_on_gp03.241250021
4x615x39somatostatin_on_gp04.08250022
E2E2x50somatostatin_on_gp03.3551212
5x36E2somatostatin_on_gp04.386251211
5x325x35somatostatin_on_gp04.676250222
5x366x59somatostatin_on_gp02.741212
5x406x55somatostatin_on_gp03.54750021
5x436x52somatostatin_on_gp03.27750212
6x517x38somatostatin_on_gp03.421212
6x58E3somatostatin_on_gp02.596250211
1x321x35somatostatin_on_gp02.70251012
2x607x42somatostatin_on_gp02.793750211
5x32E2somatostatin_on_gp02.738750221
6x55Ligsomatostatin_on_gp09.660210
2x60Ligsomatostatin_on_gp08.15250210
1x361x39somatostatin_on_gp02.81750022
2x563x32somatostatin_on_gp02.9450021
6x547x37somatostatin_on_gp04.041212
7x33E3somatostatin_on_gp02.570021
6x546x57somatostatin_on_gp02.43751212
3x323x33somatostatin_on_gp02.09751212
E1E2somatostatin_on_gp01.93251011
4x65E2x52somatostatin_on_gp01.8150021
6x606x61somatostatin_on_gp01.670021
7x327x35somatostatin_on_gp01.25750021
1x291x31somatostatin_on_gp01.126250021
7x30E3somatostatin_on_gp01.071251011
1x291x30somatostatin_on_gp00.921250022
5x345x36somatostatin_on_gp00.50021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
somatostatin_on_gp sst2_on_gp
sst4_on_gp
sst5_on_gp
somatostatin_off sst2_off
Network Difference
Value somatostatin_on_gp somatostatin_off
Imin 2.54625 3.92
Number of Linked Nodes 882 253
Number of Specific Nodes 634 (71.88%) 5  (1.98%)
Number of Shared Nodes 248 (28.12%) 248  (98.02%)
Number of Links 1100 283
Number of Specific Links 956 (86.91%) 139  (49.12%)
Number of Shared Links 144 (13.09%) 144  (50.88%)
Number of Hubs 185 33
Number of Specific Hubs 163 (88.11%) 11  (33.33%)
Number of Shared Hubs 22 (11.89%) 22  (66.67%)
Average % Shared Neighbours (Jaccard) 9.86
Average % Shared Neighbours (Otsuka) 12.69
Average % Shared Neighbours (Overlap Coefficient) 15.54
Average % Shared Cliques (k3-6) 50.82
Graphlets Similarity 0.618222
Paths Difference
Value somatostatin_on_gp somatostatin_off
Number Of Nodes in MetaPath 84 56
Specific Nodes in MetaPath 70 (83.33%) 42  (75.00%)
Shared Nodes in MetaPath 248 (28.12%) 248  (28.12%)
Number Of Links MetaPath 88 61
Specific Links in MetaPath 83 (94.32%) 56  (91.80%)
Shared Links in MetaPath 144 (13.09%) 144  (13.09%)
Number of Shortest Paths 4647321 42908
Length Of Smallest Path 3 3
Average Path Length 36.61 12.4996
Length of Longest Path 65 29
Minimum Path Strength 0.486875 1.44
Average Path Strength 5.10971 7.77815
Maximum Path Strength 22.9938 30.71
Minimum Path Correlation 0.7025 0.7
Average Path Correlation 0.984848 0.923966
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 1.72414 5
Average % Of Corr. Nodes 28.6964 53.5341
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 53.0688 42.7797
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download somatostatin_off_on_gp.zip<



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