psnGPCR

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Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	sst2_off Int. Strength	sst2_on Int. Strength	sst2_off Hub1?	sst2_on Hub1?	sst2_off Hub2?	sst2_on Hub2?	ConSurf1	ConSurf2
1	1x32	2x64	sst2_off	4.43	0	Yes	No	Yes	No	3	4
2	1x32	E1.E106	sst2_off	10.52	0	Yes	No	No	No	3	4
3	1x32	Lig	sst2_off	16.87	0	Yes	No	Yes	Yes	3	0
4	1x35	1x39	sst2_off	8.21	0	No	No	Yes	Yes	5	7
5	1x35	2x64	sst2_off	4.47	0	No	No	Yes	No	5	4
6	1x37	1x41	sst2_off	6.55	0	No	No	No	No	6	5
7	1x39	7x42	sst2_off	4.96	0	Yes	Yes	Yes	Yes	7	7
8	1x40	2x61	sst2_off	6.93	0	No	No	No	No	5	6
9	1x49	7x50	sst2_off	4.06	0	No	No	No	No	8	9
10	1x52	8x58	sst2_off	8.3	0	No	No	No	No	6	7
11	1x54	2x44	sst2_off	4.28	0	Yes	Yes	No	No	7	6
12	1x56	8x53	sst2_off	6.46	0	No	No	No	No	7	5
13	1x57	2x40	sst2_off	4.25	0	No	No	Yes	Yes	7	8
14	1x58	2x44	sst2_off	4.15	0	No	No	No	No	3	6
15	1x60	8x56	sst2_off	5.81	0	Yes	Yes	No	No	6	4
16	2x40	I1x50	sst2_off	7.01	0	Yes	Yes	Yes	No	8	7
17	8x49	I1x50	sst2_off	8.41	0	No	Yes	Yes	No	5	7
18	8x50	I1x50	sst2_off	8.71	0	Yes	Yes	Yes	No	8	7
19	8x53	I1x50	sst2_off	6.13	0	No	No	Yes	No	5	7
20	2x39	3x50	sst2_off	6.47	0	No	No	Yes	No	8	9
21	2x39	6x33	sst2_off	4.76	0	No	No	No	No	8	8
22	2x42	3x45	sst2_off	10.09	0	Yes	Yes	No	No	7	7
23	2x42	3x46	sst2_off	4.79	0	Yes	Yes	No	No	7	9
24	2x43	7x53	sst2_off	13.3	0	No	No	Yes	Yes	8	9
25	2x44	2x45	sst2_off	4.12	0	No	No	No	No	6	9
26	2x50	3x35	sst2_off	5.45	0	Yes	Yes	No	Yes	9	7
27	2x59	3x24	sst2_off	7.54	0	No	No	No	No	5	6
28	2x60	3x28	sst2_off	4.47	0	No	No	No	No	6	5
29	2x62	2x66	sst2_off	5.65	0	No	No	No	No	5	5
30	2x64	Lig	sst2_off	7.94	0	Yes	No	Yes	Yes	4	0
31	E1.E106	Lig	sst2_off	13.91	0	No	No	Yes	Yes	4	0
32	E1x49	E2.S191	sst2_off	5.58	0	No	No	No	No	4	5
33	3x22	E2.G182	sst2_off	5.23	0	No	No	No	No	3	5
34	3x29	E2x50	sst2_off	4.86	0	No	No	No	No	5	9
35	3x29	Lig	sst2_off	5.66	0	No	No	Yes	Yes	5	0
36	3x34	3x38	sst2_off	7.6	0	No	No	Yes	Yes	5	7
37	3x34	4x50	sst2_off	4.7	0	No	No	Yes	No	5	9
38	3x35	7x46	sst2_off	5.96	0	No	Yes	No	No	7	8
39	3x36	6x52	sst2_off	7.89	0	Yes	Yes	Yes	Yes	7	7
40	3x37	3x41	sst2_off	4.29	0	Yes	No	No	No	6	6
41	3x37	4x57	sst2_off	5.02	0	Yes	No	No	No	6	7
42	3x37	5x461	sst2_off	4.52	0	Yes	No	No	No	6	6
43	3x40	6x44	sst2_off	16.33	0	No	No	Yes	No	8	9
44	3x43	6x40	sst2_off	5.96	0	No	No	No	No	9	8
45	3x44	5x54	sst2_off	6.08	0	No	No	Yes	No	7	7
46	3x46	6x37	sst2_off	7.61	0	No	No	No	No	9	8
47	3x49	3x50	sst2_off	4.76	0	No	No	Yes	No	8	9
48	3x50	6x33	sst2_off	3.92	0	Yes	No	No	No	9	8
49	3x50	6x34	sst2_off	11.64	0	Yes	No	No	No	9	7
50	3x50	6x37	sst2_off	3.92	0	Yes	No	No	No	9	8
51	3x52	I2x53	sst2_off	6.01	0	No	No	No	No	4	5
52	3x54	6x30	sst2_off	5.7	0	No	No	Yes	Yes	8	6
53	4x38	4x39	sst2_off	12.97	0	No	No	No	No	6	3
54	4x59	4x62	sst2_off	4.24	0	No	No	No	No	4	5
55	4x60	5x42	sst2_off	4.17	0	No	No	No	No	8	4
56	4x64	E2.W197	sst2_off	7.72	0	No	No	Yes	Yes	4	5
57	E2.N186	E2.R190	sst2_off	6.03	0	No	No	No	No	1	1
58	E2.W197	E2x52	sst2_off	15.27	0	Yes	Yes	No	No	5	5
59	E2x52	Lig	sst2_off	8	0	No	No	Yes	Yes	5	0
60	5x36	5x40	sst2_off	6.04	0	No	No	No	No	4	5
61	5x36	6x58	sst2_off	5.09	0	No	No	No	No	4	4
62	5x39	5x43	sst2_off	7.78	0	No	Yes	No	No	7	4
63	5x44	6x56	sst2_off	6.55	0	No	No	No	No	5	5
64	5x51	5x54	sst2_off	4.28	0	No	Yes	Yes	No	6	7
65	5x54	6x41	sst2_off	4.61	0	Yes	No	No	No	7	7
66	5x58	6x38	sst2_off	7.63	0	No	No	No	No	9	4
67	5x59	5x60	sst2_off	6.09	0	No	No	No	No	4	4
68	5x59	5x63	sst2_off	4.28	0	No	No	No	No	4	3
69	5x65	6x26	sst2_off	10.46	0	No	No	No	Yes	8	4
70	6x23	6x24	sst2_off	4.89	0	No	No	No	No	3	2
71	6x26	6x30	sst2_off	11.63	0	No	Yes	Yes	Yes	4	6
72	6x26	6x31	sst2_off	13.61	0	No	Yes	No	No	4	5
73	6x27	6x29	sst2_off	4.59	0	No	No	No	No	3	5
74	6x30	6x34	sst2_off	7.06	0	Yes	Yes	No	No	6	7
75	6x39	7x56	sst2_off	7.14	0	No	No	No	No	6	6
76	6x44	7x45	sst2_off	4.83	0	Yes	No	Yes	No	9	9
77	6x46	6x47	sst2_off	4.19	0	No	No	No	No	6	8
78	6x48	6x51	sst2_off	5.01	0	Yes	Yes	Yes	Yes	8	6
79	6x49	6x50	sst2_off	4.93	0	No	No	No	No	5	9
80	6x51	6x52	sst2_off	8.25	0	Yes	Yes	Yes	Yes	6	7
81	6x54	7x33	sst2_off	9.95	0	No	Yes	No	No	4	4
82	6x54	Lig	sst2_off	9.5	0	No	Yes	Yes	Yes	4	0
83	6x61	Lig	sst2_off	4.41	0	No	No	Yes	Yes	3	0
84	7x31	E3.P286	sst2_off	6.69	0	No	No	No	No	3	2
85	7x30	Lig	sst2_off	5.4	0	No	No	Yes	Yes	4	0
86	7x34	7x38	sst2_off	7.87	0	No	No	No	No	4	6
87	7x35	Lig	sst2_off	15.53	0	No	No	Yes	Yes	2	0
88	7x38	7x42	sst2_off	5.05	0	No	No	Yes	Yes	6	7
89	7x41	7x42	sst2_off	4.99	0	No	No	Yes	Yes	7	7
90	7x49	7x53	sst2_off	4.65	0	No	Yes	Yes	Yes	9	9
91	7x53	8x50	sst2_off	8.25	0	Yes	Yes	Yes	Yes	9	8
92	8x47	8x50	sst2_off	13.14	0	No	No	Yes	Yes	8	8
93	8x52	8x63	sst2_off	5.75	0	No	No	No	No	5	3
94	8x55	8x63	sst2_off	4.07	0	No	No	No	No	4	3
95	8x56	8x63	sst2_off	9.79	0	No	No	No	No	4	3
96	1x60	8x53	sst2_off	3.82	0	Yes	Yes	No	No	6	5
97	1x53	7x53	sst2_off	3.79	0	No	No	Yes	Yes	9	9
98	1x55	8x57	sst2_off	3.79	0	No	No	Yes	No	3	5
99	1x31	Lig	sst2_off	3.74	0	No	No	Yes	Yes	4	0
100	1x40	2x62	sst2_off	3.73	0	No	No	No	No	5	5
101	3x43	6x44	sst2_off	3.65	0	No	No	Yes	No	9	9
102	3x51	5x61	sst2_off	3.63	0	Yes	Yes	No	No	8	9
103	6x36	7x53	sst2_off	3.59	0	No	No	Yes	Yes	8	9
104	1x53	2x47	sst2_off	3.39	0	No	No	No	No	9	9
105	1x30	1x33	sst2_off	3.36	0	No	No	No	No	4	4
106	3x48	5x57	sst2_off	3.27	0	No	No	No	No	6	7
107	3x29	4x65	sst2_off	3.22	0	No	No	No	No	5	4
108	5x40	6x59	sst2_off	3.07	0	No	No	No	No	5	4
109	5x34	E2.E200	sst2_off	3.02	0	No	No	No	No	1	4
110	1x52	8x57	sst2_off	2.98	0	No	No	Yes	No	6	5
111	8x57	8x58	sst2_off	2.98	0	Yes	No	No	No	5	7
112	6x43	7x45	sst2_off	2.96	0	No	No	Yes	No	7	9
113	5x40	5x41	sst2_off	2.94	0	No	No	No	No	5	5
114	5x41	5x45	sst2_off	2.94	0	No	No	No	No	5	4
115	1x30	1x32	sst2_off	2.92	0	No	No	Yes	No	4	3
116	E2.N196	E2x51	sst2_off	2.92	0	No	No	No	No	3	4
117	1x47	2x54	sst2_off	2.83	0	No	No	No	Yes	6	6
118	2x54	2x57	sst2_off	2.83	0	No	Yes	No	No	6	7
119	5x35	E2.G199	sst2_off	2.81	0	No	No	No	No	3	3
120	4x55	4x59	sst2_off	2.77	0	No	No	No	No	3	4
121	7x54	8x54	sst2_off	2.77	0	No	No	No	No	7	6
122	8x51	8x55	sst2_off	2.71	0	No	No	No	No	8	4
123	6x27	6x30	sst2_off	2.7	0	No	No	Yes	Yes	3	6
124	8x55	8x61	sst2_off	2.66	0	No	No	No	No	4	4
125	2x53	3x31	sst2_off	2.62	0	Yes	Yes	No	No	6	5
126	2x52	4x50	sst2_off	2.28	0	No	No	Yes	No	7	9
127	5x32	Lig	sst2_off	2.25	0	No	No	Yes	Yes	2	0
128	2x56	2x58	sst2_off	2.03	0	No	No	No	No	6	8
129	E2.G189	E2.S185	sst2_off	1.86	0	No	No	No	No	6	2
130	3x33	4x61	sst2_off	1.76	0	No	No	No	No	4	3
131	7x31	7x32	sst2_off	1.74	0	No	No	No	No	3	1
132	1x42	7x47	sst2_off	1.71	0	No	No	No	No	7	8
133	3x42	4x49	sst2_off	1.71	0	No	No	No	No	8	6
134	4x51	4x54	sst2_off	1.71	0	No	No	No	No	4	3
135	2x41	4x39	sst2_off	1.69	0	No	No	No	No	5	3
136	3x38	3x42	sst2_off	1.69	0	Yes	Yes	No	No	7	8
137	5x64	I2x50	sst2_off	1.67	0	No	Yes	No	No	5	8
138	3x23	3x24	sst2_off	1.62	0	No	No	No	No	1	6
139	6x59	6x60	sst2_off	1.62	0	No	No	No	No	4	4
140	4x52	4x56	sst2_off	1.6	0	No	No	Yes	No	4	4
141	8x62	8x64	sst2_off	1.6	0	No	No	No	No	2	1
142	7x48	7x52	sst2_off	1.58	0	No	No	No	Yes	6	8
143	3x39	3x40	sst2_off	1.55	0	No	No	No	No	9	8
144	4x41	4x45	sst2_off	1.52	0	No	No	No	No	5	5
145	7x27	E3.I284	sst2_off	1.52	0	Yes	No	No	No	1	1
146	5x48	5x52	sst2_off	1.47	0	No	No	No	No	4	4
147	I2x51	I2x52	sst2_off	1.45	0	No	No	No	No	5	4
148	4x43	4x47	sst2_off	1.44	0	No	No	No	No	1	4
149	6x31	6x32	sst2_off	1.44	0	No	No	No	No	5	7
150	8x47	8x48	sst2_off	1.33	0	No	No	No	No	8	5
151	5x56	5x60	sst2_off	1.22	0	No	No	No	No	5	4
152	1x35	7x35	Shared	6.79	4.52333	No	No	No	No	5	2
153	1x36	2x65	Shared	5.03	2.79667	No	No	No	No	5	5
154	1x39	2x61	Shared	4	3.11333	Yes	Yes	No	No	7	6
155	1x39	2x64	Shared	5.05	5.88667	Yes	Yes	Yes	No	7	4
156	1x43	2x57	Shared	4.76	5.82	No	No	No	No	6	7
157	1x46	2x54	Shared	5.24	2.91	No	No	No	Yes	8	6
158	1x47	2x51	Shared	5.3	4.42	No	No	No	Yes	6	7
159	1x50	2x50	Shared	8.17	5.39	No	No	Yes	Yes	9	9
160	1x50	7x50	Shared	9.77	7.60333	No	No	No	No	9	9
161	1x51	2x51	Shared	8.47	7.05333	No	No	No	Yes	5	7
162	1x54	2x48	Shared	5.89	2.45333	Yes	Yes	No	No	7	7
163	1x54	2x51	Shared	5.47	4.55667	Yes	Yes	No	Yes	7	7
164	1x55	1x59	Shared	16.46	7.20333	No	No	No	No	3	4
165	1x56	8x54	Shared	3.93	2.18333	No	No	No	No	7	6
166	1x57	8x50	Shared	5.02	3.77	No	No	Yes	Yes	7	8
167	1x59	1x60	Shared	18.52	9.60333	No	No	Yes	Yes	4	6
168	8x49	I1x49	Shared	6.99	7.92667	No	Yes	No	No	5	5
169	2x37	2x40	Shared	13.16	6.82333	No	No	Yes	Yes	7	8
170	2x38	I2x57	Shared	6.26	9.60333	No	No	No	Yes	4	5
171	2x40	8x50	Shared	7.25	3.62333	Yes	Yes	Yes	Yes	8	8
172	2x42	4x45	Shared	6.04	4.43333	Yes	Yes	No	No	7	5
173	2x43	3x46	Shared	4.37	4.37667	No	No	No	No	8	9
174	2x45	4x46	Shared	14.62	8.28333	No	No	No	No	9	7
175	2x45	4x50	Shared	6.78	5.65	No	No	Yes	No	9	9
176	2x50	7x46	Shared	10.43	8.83333	Yes	Yes	No	No	9	8
177	2x50	7x49	Shared	4.09	4.49	Yes	Yes	No	Yes	9	9
178	2x53	3x32	Shared	5.97	6.76667	Yes	Yes	No	Yes	6	6
179	2x53	3x35	Shared	21.75	10.8733	Yes	Yes	No	Yes	6	7
180	2x53	7x42	Shared	12.38	19.2533	Yes	Yes	Yes	Yes	6	7
181	2x57	7x42	Shared	4.69	17.5833	No	No	Yes	Yes	7	7
182	2x59	E1x52	Shared	12.86	6.07333	No	No	Yes	Yes	5	6
183	2x59	3x28	Shared	3.93	8.73667	No	No	No	No	5	5
184	2x63	E1x50	Shared	10.95	4.01667	No	No	Yes	Yes	5	8
185	E1x49	E1x51	Shared	4.58	4.07	No	No	No	No	4	4
186	E1x49	E2.R190	Shared	5.64	7.52667	No	No	No	No	4	1
187	E1x50	E1x52	Shared	11.02	12.0233	Yes	Yes	Yes	Yes	8	6
188	3x25	E1x50	Shared	3.92	3.91667	No	No	Yes	Yes	9	8
189	E1x50	E2.L183	Shared	5.69	4.93333	Yes	Yes	No	No	8	4
190	E1x50	E2x50	Shared	18.28	3.05	Yes	Yes	No	No	8	9
191	E1x51	E1x52	Shared	11.56	2.88667	No	No	Yes	Yes	4	6
192	3x25	E2x50	Shared	7.28	4.85333	No	No	No	No	9	9
193	3x30	4x62	Shared	6.02	6.52333	No	No	No	No	6	5
194	3x32	7x42	Shared	4.6	7.66333	No	Yes	Yes	Yes	6	7
195	3x32	Lig	Shared	11.06	7.9	No	Yes	Yes	Yes	6	0
196	3x36	3x37	Shared	10.54	3.12333	Yes	Yes	Yes	No	7	6
197	3x36	6x48	Shared	7.67	8.39667	Yes	Yes	Yes	Yes	7	8
198	3x36	Lig	Shared	8.14	8.86	Yes	Yes	Yes	Yes	7	0
199	3x37	4x56	Shared	9.18	6.11667	Yes	No	Yes	No	6	4
200	3x38	4x50	Shared	9.7	15.7667	Yes	Yes	Yes	No	7	9
201	3x38	4x53	Shared	9.59	4.79667	Yes	Yes	No	No	7	7
202	3x40	5x50	Shared	8.47	2.26	No	No	No	Yes	8	9
203	3x47	5x54	Shared	4.64	7.74	No	No	Yes	No	9	7
204	3x47	5x58	Shared	10.17	5.08667	No	No	No	No	9	9
205	3x49	I2x57	Shared	11.91	8.73667	No	No	No	Yes	8	5
206	3x51	3x55	Shared	10.09	9.25333	Yes	Yes	No	No	8	7
207	3x51	3x56	Shared	4.36	4.35667	Yes	Yes	No	Yes	8	5
208	3x51	5x57	Shared	4.03	7.16667	Yes	Yes	No	No	8	7
209	3x51	5x60	Shared	4.13	7.56333	Yes	Yes	No	No	8	4
210	3x53	I2x57	Shared	6.91	4.15	No	No	No	Yes	8	5
211	3x54	5x61	Shared	4.61	8.19333	No	No	No	No	8	9
212	3x55	3x56	Shared	9.69	6.46	No	No	No	Yes	7	5
213	3x55	5x64	Shared	6.07	5.56667	No	No	No	Yes	7	5
214	I2x50	I2x51	Shared	5.08	1.13	No	No	No	No	8	5
215	4x56	5x42	Shared	6.31	3.36667	Yes	No	No	No	4	4
216	4x56	5x46	Shared	4.47	2.98	Yes	No	No	No	4	4
217	4x57	4x62	Shared	8.75	1.94333	No	No	No	No	7	5
218	4x61	E2x52	Shared	7.36	3.43333	No	No	No	No	3	5
219	4x63	4x64	Shared	8.46	7.25333	No	No	No	No	4	4
220	4x64	E2.P198	Shared	15.3	6.49	No	No	No	No	4	5
221	E2.N186	E2.Q187	Shared	3.96	7.92333	No	No	No	No	1	2
222	E2.Q187	E2.W188	Shared	19.71	2.92333	No	No	No	No	2	2
223	E2x51	Lig	Shared	8.26	6.52333	No	No	Yes	Yes	4	0
224	5x35	E2.W197	Shared	23.43	3.75	No	No	Yes	Yes	3	5
225	5x39	E2.W197	Shared	15.03	3.67333	No	Yes	Yes	Yes	7	5
226	5x35	E2.P198	Shared	12.16	7.65667	No	No	No	No	3	5
227	5x36	Lig	Shared	23.3	11.8367	No	No	Yes	Yes	4	0
228	5x37	6x59	Shared	9.52	1.58667	No	No	No	No	3	4
229	5x42	5x46	Shared	8.21	6.64333	No	No	No	No	4	4
230	5x44	6x52	Shared	5.16	9.97333	No	No	Yes	Yes	5	7
231	5x47	5x51	Shared	7.31	4.06333	No	Yes	No	Yes	8	6
232	5x47	6x49	Shared	8.53	5.68333	No	Yes	No	No	8	5
233	5x47	6x52	Shared	20.63	8.25333	No	Yes	Yes	Yes	8	7
234	5x49	5x50	Shared	5.3	3.53	No	No	No	Yes	5	9
235	5x51	6x45	Shared	9.99	3.32667	No	Yes	No	Yes	6	6
236	6x35	6x39	Shared	5.01	1.67	No	No	No	No	6	6
237	6x36	7x56	Shared	5.65	4.24	No	No	No	No	8	6
238	6x43	7x52	Shared	4.47	1.49	No	No	No	Yes	7	8
239	6x44	6x48	Shared	18.04	5.34667	Yes	No	Yes	Yes	9	8
240	6x47	7x45	Shared	11.02	5.25	No	No	Yes	No	8	9
241	6x48	6x52	Shared	8.68	4.18	Yes	Yes	Yes	Yes	8	7
242	6x48	7x41	Shared	18.19	11.3233	Yes	Yes	No	No	8	7
243	6x48	7x45	Shared	6.78	8.28667	Yes	Yes	Yes	No	8	9
244	6x49	6x53	Shared	4.28	3.80667	No	No	No	No	5	5
245	6x51	6x55	Shared	14.5	9.66667	Yes	Yes	No	Yes	6	6
246	6x51	7x37	Shared	3.93	4.36667	Yes	Yes	No	No	6	7
247	6x51	7x41	Shared	5.19	3.89	Yes	Yes	No	No	6	7
248	6x54	7x34	Shared	13.93	6.07667	No	Yes	No	No	4	4
249	E3.P286	Lig	Shared	14.34	3.34	No	No	Yes	Yes	2	0
250	7x27	7x30	Shared	5.9	7.37	Yes	No	No	No	1	4
251	7x31	Lig	Shared	14.22	5.37667	No	No	Yes	Yes	3	0
252	7x34	Lig	Shared	17.13	18.6367	No	No	Yes	Yes	4	0
253	8x47	8x49	Shared	4.04	2.98	No	No	No	Yes	8	5
254	Lig	Lig	Shared	140.66	37.92	Yes	Yes	Yes	Yes	0	0
255	1x60	8x57	Shared	3.79	5.88667	Yes	Yes	Yes	No	6	5
256	1x43	2x58	Shared	3.77	3.14	No	No	No	No	6	8
257	E2.S192	Lig	Shared	3.74	3.73	No	No	Yes	Yes	4	0
258	2x62	E1x52	Shared	3.73	2.48667	No	No	Yes	Yes	5	6
259	E2.N196	E2.R184	Shared	3.62	10.0433	No	No	No	No	3	2
260	E3.P286	E3.S285	Shared	3.56	3.56	No	No	No	No	2	2
261	3x51	3x52	Shared	3.52	3.91	Yes	Yes	No	No	8	4
262	7x27	7x28	Shared	3.5	4.66667	Yes	No	No	No	1	3
263	E2.G182	E2.N196	Shared	3.39	3.96	No	No	No	No	5	3
264	2x49	3x38	Shared	3.36	2.24	No	No	Yes	Yes	8	7
265	6x50	7x40	Shared	3.28	2.73667	No	No	No	No	9	7
266	E2.S185	E2.S191	Shared	3.26	2.17333	No	No	No	No	2	5
267	1x54	2x47	Shared	3.25	3.25	Yes	Yes	No	No	7	9
268	2x41	4x42	Shared	3.25	2.16333	No	No	No	No	5	7
269	4x38	4x40	Shared	3.2	2.48667	No	No	No	No	6	4
270	1x36	2x64	Shared	3.17	1.06	No	No	Yes	No	5	4
271	3x27	3x30	Shared	3.17	1.06	No	No	No	No	5	6
272	1x34	1x38	Shared	3.07	1.02333	No	No	No	No	5	5
273	1x38	7x39	Shared	3.07	2.04667	No	No	No	No	5	5
274	4x46	4x47	Shared	3.01	2.51	No	No	No	No	7	4
275	3x48	5x53	Shared	2.94	2.94	No	No	No	No	6	6
276	3x21	E1x50	Shared	2.81	5.16	No	No	Yes	Yes	7	8
277	1x47	2x55	Shared	2.77	4.15	No	No	No	No	6	5
278	3x26	4x65	Shared	2.77	3.68667	No	No	No	No	6	4
279	2x46	2x50	Shared	2.75	5.43	No	No	Yes	Yes	9	9
280	2x46	7x49	Shared	2.75	5.49333	No	No	No	Yes	9	9
281	2x42	4x42	Shared	2.67	4.00333	Yes	Yes	No	No	7	7
282	1x39	7x39	Shared	2.52	9.25	Yes	Yes	No	No	7	5
283	7x51	7x55	Shared	2.51	2.09333	No	No	No	No	6	7
284	5x44	5x48	Shared	2.44	2.43667	No	No	No	No	5	4
285	7x36	7x40	Shared	2.44	3.24667	No	No	No	No	5	7
286	4x41	I2x56	Shared	2.43	2.83	No	No	No	No	5	3
287	1x46	7x47	Shared	1.96	2.61333	No	No	No	No	8	8
288	1x48	1x49	Shared	1.96	1.30667	No	No	No	No	5	8
289	5x32	5x33	Shared	1.86	1.24	No	No	No	No	2	2
290	3x33	4x57	Shared	1.76	1.76333	No	No	No	No	4	7
291	2x38	4x39	Shared	1.69	2.25667	No	No	No	No	4	3
292	7x27	7x29	Shared	1.68	1.68	Yes	No	No	No	1	1
293	1x45	7x47	Shared	1.64	1.63667	No	No	No	No	4	8
294	E2.E200	E2.G199	Shared	1.64	1.09	No	No	No	No	4	3
295	3x34	4x54	Shared	1.43	5.71	No	No	No	No	5	3
296	1x31	1x32	sst2_on	0	3.97333	No	No	Yes	No	4	3
297	1x32	7x31	sst2_on	0	3.73	Yes	No	No	No	3	3
298	1x39	2x57	sst2_on	0	7.81333	Yes	Yes	No	No	7	7
299	1x39	7x38	sst2_on	0	4.62667	Yes	Yes	No	No	7	6
300	1x50	2x51	sst2_on	0	5.26	No	No	No	Yes	9	7
301	1x53	7x54	sst2_on	0	3.39333	No	No	No	No	9	7
302	1x55	1x60	sst2_on	0	6.28667	No	No	Yes	Yes	3	6
303	1x56	8x50	sst2_on	0	6.55667	No	No	Yes	Yes	7	8
304	1x57	2x44	sst2_on	0	6.66	No	No	No	No	7	6
305	2x37	2x39	sst2_on	0	3.66333	No	No	No	No	7	8
306	2x38	2x42	sst2_on	0	4.03333	No	No	Yes	Yes	4	7
307	2x39	2x40	sst2_on	0	2.92333	No	No	Yes	Yes	8	8
308	2x42	3x49	sst2_on	0	9.96333	Yes	Yes	No	No	7	8
309	2x45	3x42	sst2_on	0	3.67333	No	No	No	No	9	8
310	2x46	3x42	sst2_on	0	3.17667	No	No	No	No	9	8
311	2x50	3x39	sst2_on	0	6.38333	Yes	Yes	No	No	9	9
312	2x50	7x50	sst2_on	0	4.29333	Yes	Yes	No	No	9	9
313	2x52	3x35	sst2_on	0	6.41	No	No	No	Yes	7	7
314	2x53	2x54	sst2_on	0	4.97667	Yes	Yes	No	Yes	6	6
315	2x53	3x36	sst2_on	0	5.07333	Yes	Yes	Yes	Yes	6	7
316	2x53	7x46	sst2_on	0	5.28333	Yes	Yes	No	No	6	8
317	2x54	7x42	sst2_on	0	3.99	No	Yes	Yes	Yes	6	7
318	2x54	7x46	sst2_on	0	4.09	No	Yes	No	No	6	8
319	2x60	Lig	sst2_on	0	8.26	No	No	Yes	Yes	6	0
320	2x63	Lig	sst2_on	0	9.28667	No	No	Yes	Yes	5	0
321	2x64	7x35	sst2_on	0	7.3	Yes	No	No	No	4	2
322	2x66	E1x49	sst2_on	0	3.43	No	No	No	No	5	4
323	E1.V106	E2.R190	sst2_on	0	4.36	No	No	No	No	0	1
324	E1x50	E2.S191	sst2_on	0	4.12	Yes	Yes	No	No	8	5
325	3x24	E1x52	sst2_on	0	6.7	No	No	Yes	Yes	6	6
326	3x31	3x35	sst2_on	0	2.95667	No	No	No	Yes	5	7
327	3x34	4x53	sst2_on	0	4.12667	No	No	No	No	5	7
328	3x34	4x57	sst2_on	0	3.92333	No	No	No	No	5	7
329	3x37	5x43	sst2_on	0	3.89	Yes	No	No	No	6	4
330	3x40	6x48	sst2_on	0	4.30667	No	No	Yes	Yes	8	8
331	3x41	4x49	sst2_on	0	3.05667	No	No	No	No	6	6
332	3x41	4x52	sst2_on	0	3.49333	No	No	No	No	6	4
333	3x43	7x49	sst2_on	0	7.32333	No	No	No	Yes	9	9
334	3x43	7x53	sst2_on	0	4.69	No	No	Yes	Yes	9	9
335	3x44	5x50	sst2_on	0	3.5	No	No	No	Yes	7	9
336	3x44	5x53	sst2_on	0	3.04	No	No	No	No	7	6
337	3x45	4x45	sst2_on	0	3.07333	No	No	No	No	7	5
338	3x46	3x50	sst2_on	0	3.72	No	No	Yes	No	9	9
339	3x46	7x53	sst2_on	0	5.98667	No	No	Yes	Yes	9	9
340	3x50	5x58	sst2_on	0	8.23	Yes	No	No	No	9	9
341	3x50	7x53	sst2_on	0	6.85667	Yes	No	Yes	Yes	9	9
342	3x56	I2x52	sst2_on	0	8.29667	No	Yes	No	No	5	4
343	I2x52	I2x56	sst2_on	0	4.25333	No	No	No	No	4	3
344	I2x53	I2x57	sst2_on	0	3.07333	No	No	No	Yes	5	5
345	4x38	4x41	sst2_on	0	3.88	No	No	No	No	6	5
346	4x59	4x60	sst2_on	0	3.28333	No	No	No	No	4	8
347	4x61	5x39	sst2_on	0	4.18667	No	No	No	Yes	3	7
348	E2.L183	E2.S191	sst2_on	0	5.50667	No	No	No	No	4	5
349	5x36	E2.W197	sst2_on	0	7.39667	No	No	Yes	Yes	4	5
350	E2.W197	Lig	sst2_on	0	3.00667	Yes	Yes	Yes	Yes	5	0
351	5x38	5x41	sst2_on	0	2.94	No	No	No	No	4	5
352	5x39	Lig	sst2_on	0	9.53667	No	Yes	Yes	Yes	7	0
353	5x40	6x55	sst2_on	0	7.55333	No	No	No	Yes	5	6
354	5x43	6x52	sst2_on	0	5.82667	No	No	Yes	Yes	4	7
355	5x43	Lig	sst2_on	0	6.94333	No	No	Yes	Yes	4	0
356	5x44	5x47	sst2_on	0	6.43333	No	No	No	Yes	5	8
357	5x47	6x45	sst2_on	0	3.35	No	Yes	No	Yes	8	6
358	5x51	6x44	sst2_on	0	4.46667	No	Yes	Yes	No	6	9
359	5x58	6x37	sst2_on	0	10.9367	No	No	No	No	9	8
360	5x62	6x30	sst2_on	0	3.64333	No	Yes	Yes	Yes	5	6
361	5x62	6x34	sst2_on	0	5.06667	No	Yes	No	No	5	7
362	5x64	5x67	sst2_on	0	3.57	No	Yes	No	No	5	5
363	5x66	6x30	sst2_on	0	10.8	No	No	Yes	Yes	4	6
364	6x26	I3.I240	sst2_on	0	3.34	No	Yes	No	Yes	4	0
365	6x40	7x52	sst2_on	0	3.47667	No	No	No	Yes	8	8
366	6x45	6x49	sst2_on	0	4.28	No	Yes	No	No	6	5
367	6x51	Lig	sst2_on	0	4.74667	Yes	Yes	Yes	Yes	6	0
368	6x54	6x55	sst2_on	0	3.22333	No	Yes	No	Yes	4	6
369	6x55	7x34	sst2_on	0	4.43	No	Yes	No	No	6	4
370	6x60	6x61	sst2_on	0	3.57667	No	No	No	No	4	3
371	E3.I284	Lig	sst2_on	0	3.98	No	No	Yes	Yes	1	0
372	7x31	7x35	sst2_on	0	6.45333	No	No	No	No	3	2
373	7x42	Lig	sst2_on	0	5.78333	Yes	Yes	Yes	Yes	7	0
374	7x45	7x49	sst2_on	0	8.63	Yes	No	No	Yes	9	9
375	7x52	7x53	sst2_on	0	4.68667	No	Yes	Yes	Yes	8	9
376	7x54	8x50	sst2_on	0	3.69667	No	No	Yes	Yes	7	8
377	8x48	8x52	sst2_on	0	5.99	No	No	No	No	5	5
378	1x35	7x36	sst2_on	0	3.65333	No	No	No	No	5	5
379	3x32	3x35	sst2_on	0	3.59	No	Yes	No	Yes	6	7
380	E2.R184	E2.W197	sst2_on	0	10.9967	No	No	Yes	Yes	2	5
381	5x66	I3.I240	sst2_on	0	3.39333	No	No	No	Yes	4	0
382	6x27	I3.I240	sst2_on	0	6.78667	No	No	No	Yes	3	0
383	6x28	6x32	sst2_on	0	4.31	No	No	No	No	4	7
384	6x30	6x31	sst2_on	0	6.75	Yes	Yes	No	No	6	5
385	6x54	7x37	sst2_on	0	3.06	No	Yes	No	No	4	7
386	6x55	Lig	sst2_on	0	2.99	No	Yes	Yes	Yes	6	0
387	7x30	7x33	sst2_on	0	3.3	No	No	No	No	4	4
388	8x49	8x53	sst2_on	0	5.46333	No	Yes	No	No	5	5
389	4x38	I2x57	sst2_on	0	7.10667	No	No	No	Yes	6	5
390	5x32	E2.W197	sst2_on	0	3.29333	No	No	Yes	Yes	2	5
391	5x63	5x64	sst2_on	0	2.90667	No	No	No	Yes	3	5
392	3x47	5x57	sst2_on	0	2.86667	No	No	No	No	9	7
393	2x44	2x48	sst2_on	0	2.85333	No	No	No	No	6	7
394	7x55	7x56	sst2_on	0	2.84333	No	No	No	No	7	6
395	2x40	I1x49	sst2_on	0	2.79667	Yes	Yes	No	No	8	5
396	1x42	7x39	sst2_on	0	2.67333	No	No	No	No	7	5
397	3x38	4x49	sst2_on	0	2.64667	Yes	Yes	No	No	7	6
398	I3.I240	I3.R241	sst2_on	0	2.50667	No	Yes	No	No	0	0
399	6x26	I3.G239	sst2_on	0	2.5	No	Yes	No	No	4	0
400	4x40	4x44	sst2_on	0	2.48	No	No	No	No	4	1
401	2x41	I1x50	sst2_on	0	2.43	No	No	Yes	No	5	7
402	5x37	5x38	sst2_on	0	2.42667	No	No	No	No	3	4
403	I1x50	I1x51	sst2_on	0	2.4	Yes	No	No	No	7	7
404	7x30	E3.I284	sst2_on	0	2.38	No	No	No	No	4	1
405	3x22	E2.L183	sst2_on	0	2.35	No	No	No	No	3	4
406	5x51	5x55	sst2_on	0	2.11333	No	Yes	No	No	6	5
407	3x22	3x26	sst2_on	0	2.06333	No	No	No	No	3	6
408	5x62	6x33	sst2_on	0	2.04667	No	Yes	No	No	5	8
409	5x62	6x37	sst2_on	0	2.04667	No	Yes	No	No	5	8
410	5x64	5x68	sst2_on	0	2.04	No	Yes	No	No	5	0
411	1x52	8x54	sst2_on	0	2.03	No	No	No	No	6	6
412	5x461	5x50	sst2_on	0	2.03	No	No	No	Yes	6	9
413	3x54	5x64	sst2_on	0	2.02667	No	No	No	Yes	8	5
414	E2.N186	E2.S192	sst2_on	0	1.98667	No	No	No	No	1	4
415	3x29	E2x52	sst2_on	0	1.94667	No	No	No	No	5	5
416	2x41	4x43	sst2_on	0	1.93667	No	No	No	No	5	1
417	4x60	5x39	sst2_on	0	1.92667	No	No	No	Yes	8	7
418	5x45	5x46	sst2_on	0	1.90333	No	No	No	No	4	4
419	1x54	1x58	sst2_on	0	1.9	Yes	Yes	No	No	7	3
420	6x58	Lig	sst2_on	0	1.86667	No	No	Yes	Yes	4	0
421	8x49	8x52	sst2_on	0	1.86667	No	Yes	No	No	5	5
422	6x42	6x46	sst2_on	0	1.85	No	No	No	No	5	6
423	I3.G243	I3.V242	sst2_on	0	1.84	No	No	No	No	0	0
424	6x59	Lig	sst2_on	0	1.74667	No	No	Yes	Yes	4	0
425	1x36	1x40	sst2_on	0	1.73	No	No	No	No	5	5
426	1x35	7x32	sst2_on	0	1.71	No	No	No	No	5	1
427	1x49	1x52	sst2_on	0	1.71	No	No	No	No	8	6
428	5x55	6x41	sst2_on	0	1.70667	No	No	No	No	5	7
429	1x56	1x60	sst2_on	0	1.68333	No	No	Yes	Yes	7	6
430	2x56	3x32	sst2_on	0	1.67667	No	No	No	Yes	6	6
431	6x31	6x35	sst2_on	0	1.65	No	No	No	No	5	6
432	1x28	7x28	sst2_on	0	1.61	No	No	No	No	0	3
433	I1x48	I1x51	sst2_on	0	1.60667	No	No	No	No	5	7
434	3x56	I2x50	sst2_on	0	1.53	No	Yes	No	No	5	8
435	5x52	5x53	sst2_on	0	1.52	No	No	No	No	4	6
436	6x25	6x28	sst2_on	0	1.43667	No	No	No	No	3	4
437	5x65	6x30	sst2_on	0	1.42667	No	No	Yes	Yes	8	6
438	7x52	7x56	sst2_on	0	1.38333	No	Yes	No	No	8	6
439	I2x54	I2x57	sst2_on	0	1.38333	No	No	No	Yes	4	5
440	E2.G199	E2.P198	sst2_on	0	1.35333	No	No	No	No	3	5
441	6x45	6x46	sst2_on	0	1.25667	No	Yes	No	No	6	6
442	6x23	I3.G243	sst2_on	0	1.23667	No	No	No	No	3	0
443	6x25	6x26	sst2_on	0	1.23667	No	No	No	Yes	3	4
444	6x43	7x48	sst2_on	0	1.13333	No	No	No	No	7	6
445	5x65	6x29	sst2_on	0	1.08	No	No	No	No	8	5
446	6x38	6x39	sst2_on	0	1.03333	No	No	No	No	4	6
447	5x40	6x56	sst2_on	0	1.02667	No	No	No	No	5	5
448	1x41	1x45	sst2_on	0	1.02333	No	No	No	No	5	4
449	6x24	6x25	sst2_on	0	1.02	No	No	No	No	2	3
450	E2.G189	E2.R190	sst2_on	0	1	No	No	No	No	6	1
451	5x52	5x56	sst2_on	0	0.983333	No	No	No	No	4	5
452	8x48	8x51	sst2_on	0	0.923333	No	No	No	No	5	8
453	6x54	6x57	sst2_on	0	0.88	No	Yes	No	No	4	4
454	6x23	6x26	sst2_on	0	0.88	No	No	No	Yes	3	4
455	1x37	1x40	sst2_on	0	0.713333	No	No	No	No	6	5
456	6x47	7x43	sst2_on	0	0.603333	No	No	No	No	8	5
457	1x30	1x34	sst2_on	0	0.53	No	No	No	No	4	5
458	1x41	1x44	sst2_on	0	0.513333	No	No	No	No	5	4
459	8x56	8x57	sst2_on	0	0.493333	No	No	Yes	No	4	5
460	I2x52	I2x55	sst2_on	0	0.48	No	No	No	No	4	4
461	4x50	4x51	sst2_on	0	0.47	Yes	No	No	No	9	4
462	5x34	5x35	sst2_on	0	0.433333	No	No	No	No	1	3

Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	sst2_off Avg Int. Strength	sst2_on Avg Int. Strength	sst2_off Num Of Links	sst2_on Num Of Links	ConSurf
1	1x32	sst2_off	8.685	3.85167	4	2	3
2	I1x50	sst2_off	7.565	2.415	4	2	7
3	2x64	sst2_off	5.012	4.74889	5	3	4
4	3x37	sst2_off	6.71	4.37667	5	3	6
5	3x50	sst2_off	6.142	6.26889	5	3	9
6	4x50	sst2_off	5.865	7.29556	4	3	9
7	4x56	sst2_off	5.39	4.15444	4	3	4
8	5x54	sst2_off	4.9025	7.74	4	1	7
9	6x44	sst2_off	10.7125	4.90667	4	2	9
10	7x27	sst2_off	3.15	4.57222	4	3	1
11	7x45	sst2_off	6.3975	7.38889	4	3	9
12	8x57	sst2_off	3.385	3.19	4	2	5
13	1x39	Shared	4.948	6.138	5	5	7
14	1x54	Shared	4.7225	3.04	4	4	7
15	1x60	Shared	7.985	5.865	4	4	6
16	2x40	Shared	7.9175	4.04167	4	4	8
17	2x42	Shared	5.8975	5.60833	4	4	7
18	2x50	Shared	6.178	5.80333	5	6	9
19	2x53	Shared	10.68	8.70444	4	6	6
20	E1x50	Shared	8.77833	5.31714	6	7	8
21	E1x52	Shared	9.7925	6.034	4	5	6
22	3x36	Shared	8.56	6.36333	4	4	7
23	3x38	Shared	6.388	6.3625	5	4	7
24	3x51	Shared	4.96	6.45	6	5	8
25	E2.W197	Shared	15.3625	5.35278	4	6	5
26	6x30	Shared	6.7725	5.655	4	4	6
27	6x48	Shared	10.7283	6.97333	6	6	8
28	6x51	Shared	7.376	5.6675	5	4	6
29	6x52	Shared	10.122	7.05833	5	4	7
30	7x42	Shared	6.11167	10.8547	6	5	7
31	7x53	Shared	6.716	5.555	5	4	9
32	8x50	Shared	8.474	4.41167	5	4	8
33	Lig	Shared	22.6057	9.53286	21	21	0
34	2x51	sst2_on	6.41333	5.3225	3	4	7
35	2x54	sst2_on	3.63333	3.99167	3	4	6
36	3x32	sst2_on	7.21	5.51933	3	5	6
37	3x35	sst2_on	11.0533	5.9575	3	4	7
38	3x56	sst2_on	7.025	5.16083	2	4	5
39	I2x57	sst2_on	8.36	5.67556	3	6	5
40	5x39	sst2_on	11.405	4.83083	2	4	7
41	5x47	sst2_on	12.1567	5.55667	3	5	8
42	5x50	sst2_on	6.885	2.83	2	4	9
43	5x51	sst2_on	7.19333	3.4925	3	4	6
44	5x62	sst2_on	0	3.20083	0	4	5
45	5x64	sst2_on	3.87	3.222	2	5	5
46	I3.I240	sst2_on	0	4.00667	0	4	0
47	6x26	sst2_on	11.9	1.98917	3	4	4
48	6x45	sst2_on	9.99	3.05333	1	4	6
49	6x54	sst2_on	11.1267	3.31	3	4	4
50	6x55	sst2_on	14.5	5.57267	1	5	6
51	7x49	sst2_on	3.83	6.48417	3	4	9
52	7x52	sst2_on	3.025	2.75917	2	4	8
53	8x49	sst2_on	6.48	4.55917	3	4	5

Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	sst2_off Recurrence	sst2_on Recurrence	sst2_off Hub1?	sst2_on Hub1?	sst2_off Hub2?	sst2_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x61	sst2_off	17.4301	1.84214	Yes	Yes	No	No	7	6
2	1x39	7x42	sst2_off	22.2888	0	Yes	Yes	Yes	Yes	7	7
3	3x32	7x42	sst2_off	13.6827	0.378683	No	Yes	Yes	Yes	6	7
4	1x40	2x61	sst2_off	16.0303	0	No	No	No	No	5	6
5	2x54	2x57	sst2_off	28.7924	0	No	Yes	No	No	6	7
6	1x47	2x54	sst2_off	26.2868	0	No	No	No	Yes	6	6
7	1x47	2x51	sst2_off	25.241	4.42192	No	No	No	Yes	6	7
8	2x53	3x35	sst2_off	100	2.422	Yes	Yes	No	Yes	6	7
9	2x50	3x35	sst2_off	98.2624	0	Yes	Yes	No	Yes	9	7
10	7x49	7x53	sst2_off	94.6566	0	No	Yes	Yes	Yes	9	9
11	7x53	8x50	sst2_off	44.4795	0	Yes	Yes	Yes	Yes	9	8
12	8x50	I1x50	sst2_off	32.3002	0	Yes	Yes	Yes	No	8	7
13	8x53	I1x50	sst2_off	28.1824	0	No	No	Yes	No	5	7
14	1x60	8x53	sst2_off	21.7986	0	Yes	Yes	No	No	6	5
15	1x54	2x44	sst2_off	25.1811	0	Yes	Yes	No	No	7	6
16	1x60	8x56	sst2_off	10.2075	0	Yes	Yes	No	No	6	4
17	2x43	7x53	sst2_off	69.8404	0	No	No	Yes	Yes	8	9
18	2x43	3x46	sst2_off	68.6203	1.26228	No	No	No	No	8	9
19	2x42	3x46	sst2_off	17.6099	0	Yes	Yes	No	No	7	9
20	3x46	6x37	sst2_off	52.1543	0	No	No	No	No	9	8
21	3x50	6x37	sst2_off	50.7598	0	Yes	No	No	No	9	8
22	2x44	2x45	sst2_off	22.1853	0	No	No	No	No	6	9
23	3x29	Lig	sst2_off	29.0157	0	No	No	Yes	Yes	5	0
24	3x29	E2x50	sst2_off	25.4916	0	No	No	No	No	5	9
25	E1x50	E2x50	sst2_off	23.0677	1.93681	Yes	Yes	No	No	8	9
26	1x40	2x62	sst2_off	14.6413	0	No	No	No	No	5	5
27	E1x49	E1x51	sst2_off	15.6381	9.64065	No	No	No	No	4	4
28	3x36	3x37	sst2_off	21.7278	6.06288	Yes	Yes	Yes	No	7	6
29	3x36	6x52	sst2_off	21.9892	0	Yes	Yes	Yes	Yes	7	7
30	5x47	6x52	sst2_off	37.3604	8.09041	No	Yes	Yes	Yes	8	7
31	5x47	5x51	sst2_off	21.6079	1.32934	No	Yes	No	Yes	8	6
32	5x51	5x54	sst2_off	16.2699	0	No	Yes	Yes	No	6	7
33	3x50	6x34	sst2_off	41.6526	0	Yes	No	No	No	9	7
34	6x30	6x34	sst2_off	40.2037	0	Yes	Yes	No	No	6	7
35	3x54	6x30	sst2_off	29.6748	0	No	No	Yes	Yes	8	6
36	3x54	5x61	sst2_off	28.117	1.25833	No	No	No	No	8	9
37	3x51	5x61	sst2_off	26.6627	0	Yes	Yes	No	No	8	9
38	E2x52	Lig	sst2_off	18.6448	0	No	No	Yes	Yes	5	0
39	E2.W197	E2x52	sst2_off	15.5564	0	Yes	Yes	No	No	5	5
40	5x36	Lig	sst2_off	11.2479	1.6883	No	No	Yes	Yes	4	0
41	5x44	6x52	sst2_off	10.8884	2.28393	No	No	Yes	Yes	5	7
42	5x47	6x49	sst2_off	13.5846	2.33127	No	Yes	No	No	8	5
43	6x51	6x52	sst2_off	15.7797	0	Yes	Yes	Yes	Yes	6	7
44	7x41	7x42	sst2_off	44.5068	0	No	No	Yes	Yes	7	7
45	6x48	7x41	sst2_off	27.4961	5.53824	Yes	Yes	No	No	8	7
46	1x53	7x53	sst2_off	15.2241	0	No	No	Yes	Yes	9	9
47	1x54	2x47	sst2_off	14.0748	2.21293	Yes	Yes	No	No	7	9
48	1x53	2x47	sst2_off	13.8243	0	No	No	No	No	9	9
49	2x62	E1x52	sst2_off	12.7349	1.94075	No	No	Yes	Yes	5	6
50	6x51	7x41	sst2_off	16.5151	5.22662	Yes	Yes	No	No	6	7
51	6x48	6x52	sst2_off	15.4148	6.74135	Yes	Yes	Yes	Yes	8	7
52	3x32	Lig	Shared	69.2358	20.6856	No	Yes	Yes	Yes	6	0
53	2x57	7x42	Shared	34.0868	24.8984	No	No	Yes	Yes	7	7
54	2x53	3x32	Shared	55.7765	20.015	Yes	Yes	No	Yes	6	6
55	2x50	7x49	Shared	94.7001	33.474	Yes	Yes	No	Yes	9	9
56	1x54	2x51	Shared	24.2824	59.1456	Yes	Yes	No	Yes	7	7
57	2x45	4x50	Shared	16.063	37.1544	No	No	Yes	No	9	9
58	E1x50	E1x52	Shared	18.2908	20.9538	Yes	Yes	Yes	Yes	8	6
59	E1x51	E1x52	Shared	17.5445	11.5459	No	No	Yes	Yes	4	6
60	3x36	Lig	Shared	44.5449	61.9502	Yes	Yes	Yes	Yes	7	0
61	3x36	6x48	Shared	11.749	46.3571	Yes	Yes	Yes	Yes	7	8
62	2x53	7x42	Shared	45.7214	29.6241	Yes	Yes	Yes	Yes	6	7
63	7x31	7x35	sst2_on	0	15.2538	No	No	No	No	3	2
64	7x31	Lig	sst2_on	2.925	20.1767	No	No	Yes	Yes	3	0
65	7x42	Lig	sst2_on	0	44.3533	Yes	Yes	Yes	Yes	7	0
66	2x53	7x46	sst2_on	0	69.5949	Yes	Yes	No	No	6	8
67	2x50	7x46	sst2_on	0.588267	100	Yes	Yes	No	No	9	8
68	1x50	2x50	sst2_on	6.92303	68.873	No	No	Yes	Yes	9	9
69	2x53	3x36	sst2_on	0	22.9222	Yes	Yes	Yes	Yes	6	7
70	2x54	7x42	sst2_on	0	30.5945	No	Yes	Yes	Yes	6	7
71	2x54	7x46	sst2_on	0	31.4465	No	Yes	No	No	6	8
72	1x50	2x51	sst2_on	0	67.0506	No	No	No	Yes	9	7
73	1x54	2x48	sst2_on	1.65042	53.134	Yes	Yes	No	No	7	7
74	2x44	2x48	sst2_on	0	51.1144	No	No	No	No	6	7
75	1x57	2x44	sst2_on	0	49.0868	No	No	No	No	7	6
76	1x57	8x50	sst2_on	1.60684	47.0475	No	No	Yes	Yes	7	8
77	1x56	8x50	sst2_on	0	20.3187	No	No	Yes	Yes	7	8
78	2x40	8x50	sst2_on	3.13743	21.7901	Yes	Yes	Yes	Yes	8	8
79	6x48	7x45	sst2_on	8.24119	58.976	Yes	Yes	Yes	No	8	9
80	7x45	7x49	sst2_on	0	58.7985	Yes	No	No	Yes	9	9
81	3x43	7x49	sst2_on	0	78.8135	No	No	No	Yes	9	9
82	3x43	7x53	sst2_on	0	78.1823	No	No	Yes	Yes	9	9
83	3x50	7x53	sst2_on	0	70.7112	Yes	No	Yes	Yes	9	9
84	3x50	5x58	sst2_on	0	70.7467	Yes	No	No	No	9	9
85	3x47	5x58	sst2_on	5.46326	51.5246	No	No	No	No	9	9
86	3x47	5x57	sst2_on	0	49.7258	No	No	No	No	9	7
87	3x51	5x57	sst2_on	5.20726	48.8146	Yes	Yes	No	No	8	7
88	3x51	3x56	sst2_on	1.71578	38.46	Yes	Yes	No	Yes	8	5
89	3x56	I2x52	sst2_on	0	36.4009	No	Yes	No	No	5	4
90	I2x52	I2x56	sst2_on	0	34.3497	No	No	No	No	4	3
91	4x41	I2x56	sst2_on	1.63408	33.3123	No	No	No	No	5	3
92	4x38	4x41	sst2_on	0	32.4366	No	No	No	No	6	5
93	4x38	I2x57	sst2_on	0	29.2533	No	No	No	Yes	6	5
94	2x38	I2x57	sst2_on	2.40209	13.0527	No	No	No	Yes	4	5
95	2x38	2x42	sst2_on	0	10.753	No	No	Yes	Yes	4	7
96	3x49	I2x57	sst2_on	5.69748	11.8457	No	No	No	Yes	8	5
97	2x42	3x49	sst2_on	0	10.6899	Yes	Yes	No	No	7	8
98	2x42	4x42	sst2_on	9.49398	14.386	Yes	Yes	No	No	7	7
99	2x46	2x50	sst2_on	1.18198	32.3419	No	No	Yes	Yes	9	9
100	2x46	3x42	sst2_on	0	46.7634	No	No	No	No	9	8
101	2x45	3x42	sst2_on	0	44.373	No	No	No	No	9	8
102	2x46	7x49	sst2_on	0.56648	16.8001	No	No	No	Yes	9	9
103	2x63	Lig	sst2_on	0	40.7163	No	No	Yes	Yes	5	0
104	2x63	E1x50	sst2_on	1.48701	39.1779	No	No	Yes	Yes	5	8
105	3x38	4x50	sst2_on	8.08323	32.3025	Yes	Yes	Yes	No	7	9
106	3x38	4x53	sst2_on	1.65042	20.0347	Yes	Yes	No	No	7	7
107	3x34	4x53	sst2_on	0	17.5575	No	No	No	No	5	7
108	3x34	4x57	sst2_on	0	12.5794	No	No	No	No	5	7
109	3x40	6x48	sst2_on	0	10.824	No	No	Yes	Yes	8	8
110	5x39	Lig	sst2_on	0	10.4651	No	Yes	Yes	Yes	7	0
111	E2.W197	Lig	sst2_on	0	23.0287	Yes	Yes	Yes	Yes	5	0
112	5x35	E2.W197	sst2_on	7.2553	12.7806	No	No	Yes	Yes	3	5
113	5x58	6x37	sst2_on	0	27.707	No	No	No	No	9	8
114	5x62	6x37	sst2_on	0	26.784	No	Yes	No	No	5	8
115	5x62	6x30	sst2_on	0	23.6401	No	Yes	Yes	Yes	5	6
116	5x66	6x30	sst2_on	0	15.8258	No	No	Yes	Yes	4	6
117	5x66	I3.I240	sst2_on	0	14.6621	No	No	No	Yes	4	0
118	6x26	I3.I240	sst2_on	0	11.1002	No	Yes	No	Yes	4	0
119	E3.I284	Lig	sst2_on	0	12.7845	No	No	Yes	Yes	1	0
120	7x30	E3.I284	sst2_on	0	11.1199	No	No	No	No	4	1
121	2x40	I1x49	sst2_on	0	15.3446	Yes	Yes	No	No	8	5
122	8x49	I1x49	sst2_on	3.34986	13.175	No	Yes	No	No	5	5
123	2x41	4x42	sst2_on	7.94161	12.0074	No	No	No	No	5	7
124	1x39	2x57	sst2_on	0	19.9479	Yes	Yes	No	No	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x32	2x64	sst2_off	4.43	0	1	0	1	1
1x32	E1.E106	sst2_off	10.52	0	1	0	1	1
1x32	Lig	sst2_off	16.87	0	1	0	1	0
1x35	1x39	sst2_off	8.21	0	1	0	2	2
1x35	2x64	sst2_off	4.47	0	1	0	2	1
1x35	7x35	Shared	6.79	4.52333	1	0	2	1
1x39	2x64	Shared	5.05	5.88667	1	0	2	1
1x39	7x42	sst2_off	4.96	0	1	0	2	1
2x53	3x32	Shared	5.97	6.76667	1	1	2	1
2x53	3x35	Shared	21.75	10.8733	1	1	2	2
2x53	7x42	Shared	12.38	19.2533	1	1	2	1
2x57	7x42	Shared	4.69	17.5833	0	0	2	1
2x60	3x28	sst2_off	4.47	0	0	0	1	2
2x63	E1x50	Shared	10.95	4.01667	0	1	1	2
2x64	Lig	sst2_off	7.94	0	1	0	1	0
E1.E106	Lig	sst2_off	13.91	0	1	0	1	0
E1x50	E2x50	Shared	18.28	3.05	1	1	2	2
3x29	E2x50	sst2_off	4.86	0	1	0	1	2
3x29	Lig	sst2_off	5.66	0	1	0	1	0
3x32	7x42	Shared	4.6	7.66333	1	1	1	1
3x32	Lig	Shared	11.06	7.9	1	1	1	0
3x36	3x37	Shared	10.54	3.12333	1	1	1	2
3x36	6x48	Shared	7.67	8.39667	1	1	1	2
3x36	6x52	sst2_off	7.89	0	1	1	1	2
3x36	Lig	Shared	8.14	8.86	1	1	1	0
4x61	E2x52	Shared	7.36	3.43333	0	0	2	1
4x64	E2.W197	sst2_off	7.72	0	0	0	2	1
E2x51	Lig	Shared	8.26	6.52333	1	0	1	0
E2.W197	E2x52	sst2_off	15.27	0	0	1	1	1
E2x52	Lig	sst2_off	8	0	1	0	1	0
5x35	E2.W197	Shared	23.43	3.75	0	0	2	1
5x39	E2.W197	Shared	15.03	3.67333	0	1	1	1
5x36	5x40	sst2_off	6.04	0	1	1	1	2
5x36	6x58	sst2_off	5.09	0	1	1	1	1
5x36	Lig	Shared	23.3	11.8367	1	1	1	0
5x37	6x59	Shared	9.52	1.58667	0	0	2	1
5x39	5x43	sst2_off	7.78	0	0	1	1	1
6x48	6x51	sst2_off	5.01	0	1	0	2	1
6x48	6x52	Shared	8.68	4.18	1	0	2	2
6x48	7x41	Shared	18.19	11.3233	1	0	2	2
6x51	6x52	sst2_off	8.25	0	1	1	1	2
6x51	6x55	Shared	14.5	9.66667	1	1	1	1
6x51	7x37	Shared	3.93	4.36667	1	1	1	2
6x51	7x41	Shared	5.19	3.89	1	1	1	2
6x54	7x33	sst2_off	9.95	0	1	1	1	2
6x54	7x34	Shared	13.93	6.07667	1	1	1	1
6x54	Lig	sst2_off	9.5	0	1	1	1	0
6x61	Lig	sst2_off	4.41	0	0	0	1	0
7x31	E3.P286	sst2_off	6.69	0	1	1	1	1
E3.P286	Lig	Shared	14.34	3.34	1	1	1	0
7x27	7x30	Shared	5.9	7.37	0	0	2	1
7x30	Lig	sst2_off	5.4	0	1	0	1	0
7x31	Lig	Shared	14.22	5.37667	1	1	1	0
7x34	7x38	sst2_off	7.87	0	1	1	1	2
7x34	Lig	Shared	17.13	18.6367	1	1	1	0
7x35	Lig	sst2_off	15.53	0	1	0	1	0
7x38	7x42	sst2_off	5.05	0	0	0	2	1
7x41	7x42	sst2_off	4.99	0	1	0	2	1
1x31	Lig	sst2_off	3.74	0	0	0	1	0
E2.S192	Lig	Shared	3.74	3.73	0	1	1	0
E2.N196	E2.R184	Shared	3.62	10.0433	0	0	2	2
E3.P286	E3.S285	Shared	3.56	3.56	1	1	1	2
3x29	4x65	sst2_off	3.22	0	1	0	1	2
1x36	2x64	Shared	3.17	1.06	0	0	2	1
5x40	6x59	sst2_off	3.07	0	0	0	2	1
1x30	1x32	sst2_off	2.92	0	0	0	2	1
E2.N196	E2x51	sst2_off	2.92	0	0	0	2	1
2x54	2x57	sst2_off	2.83	0	0	1	2	2
5x32	Lig	sst2_off	2.25	0	1	0	1	0
5x32	5x33	Shared	1.86	1.24	1	0	1	2
7x31	7x32	sst2_off	1.74	0	1	1	1	2
6x59	6x60	sst2_off	1.62	0	0	1	1	2
7x27	E3.I284	sst2_off	1.52	0	0	0	2	1
1x31	1x32	sst2_on	0	3.97333	0	0	1	1
1x32	7x31	sst2_on	0	3.73	1	0	1	1
1x39	2x57	sst2_on	0	7.81333	1	0	2	2
1x39	7x38	sst2_on	0	4.62667	1	0	2	2
2x53	2x54	sst2_on	0	4.97667	1	1	2	2
2x53	3x36	sst2_on	0	5.07333	1	1	2	1
2x54	7x42	sst2_on	0	3.99	0	1	2	1
2x60	Lig	sst2_on	0	8.26	0	0	1	0
2x63	Lig	sst2_on	0	9.28667	0	1	1	0
2x64	7x35	sst2_on	0	7.3	1	0	1	1
3x37	5x43	sst2_on	0	3.89	0	0	2	1
4x61	5x39	sst2_on	0	4.18667	0	0	2	1
5x36	E2.W197	sst2_on	0	7.39667	1	1	1	1
E2.W197	Lig	sst2_on	0	3.00667	0	1	1	0
5x39	Lig	sst2_on	0	9.53667	0	1	1	0
5x40	6x55	sst2_on	0	7.55333	0	0	2	1
5x43	6x52	sst2_on	0	5.82667	0	1	1	2
5x43	Lig	sst2_on	0	6.94333	0	1	1	0
6x51	Lig	sst2_on	0	4.74667	1	1	1	0
6x54	6x55	sst2_on	0	3.22333	1	1	1	1
6x55	7x34	sst2_on	0	4.43	0	1	1	1
6x60	6x61	sst2_on	0	3.57667	0	0	2	1
E3.I284	Lig	sst2_on	0	3.98	0	1	1	0
7x31	7x35	sst2_on	0	6.45333	1	1	1	1
7x42	Lig	sst2_on	0	5.78333	1	1	1	0
3x32	3x35	sst2_on	0	3.59	1	1	1	2
E2.R184	E2.W197	sst2_on	0	10.9967	0	0	2	1
6x54	7x37	sst2_on	0	3.06	1	1	1	2
6x55	Lig	sst2_on	0	2.99	0	1	1	0
7x30	7x33	sst2_on	0	3.3	1	0	1	2
5x32	E2.W197	sst2_on	0	3.29333	1	0	1	1
7x30	E3.I284	sst2_on	0	2.38	1	0	1	1
E2.N186	E2.S192	sst2_on	0	1.98667	0	0	2	1
3x29	E2x52	sst2_on	0	1.94667	1	0	1	1
4x60	5x39	sst2_on	0	1.92667	0	0	2	1
6x58	Lig	sst2_on	0	1.86667	0	0	1	0
6x59	Lig	sst2_on	0	1.74667	0	1	1	0
1x35	7x32	sst2_on	0	1.71	1	0	2	2
2x56	3x32	sst2_on	0	1.67667	0	0	2	1
6x54	6x57	sst2_on	0	0.88	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	sst2_off	7XNA-SST2-CYN154806
	sst2_on	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2

Network Difference
Value	sst2_off	sst2_on
I_min	3.92	2.92
Number of Linked Nodes	268	281
Number of Specific Nodes	11 (4.10%)	24 (8.54%)
Number of Shared Nodes	257 (95.90%)	257 (91.46%)
Number of Links	295	311
Number of Specific Links	151 (51.19%)	167 (53.70%)
Number of Shared Links	144 (48.81%)	144 (46.30%)
Number of Hubs	33	41
Number of Specific Hubs	12 (36.36%)	20 (48.78%)
Number of Shared Hubs	21 (63.64%)	21 (51.22%)
Average % Shared Neighbours (Jaccard)	32.40
Average % Shared Neighbours (Otsuka)	41.44
Average % Shared Neighbours (Overlap Coefficient)	49.69
Average % Shared Cliques (k3-6)	78.38
Graphlets Similarity	0.57859

Paths Difference
Value	sst2_off	sst2_on
Number Of Nodes in MetaPath	57	68
Specific Nodes in MetaPath	30 (52.63%)	41 (60.29%)
Shared Nodes in MetaPath	257 (95.90%)	257 (95.90%)
Number Of Links MetaPath	62	73
Specific Links in MetaPath	51 (82.26%)	62 (84.93%)
Shared Links in MetaPath	144 (48.81%)	144 (48.81%)
Number of Shortest Paths	42116	61940
Length Of Smallest Path	3	3
Average Path Length	12.619	14.1544
Length of Longest Path	31	35
Minimum Path Strength	1.57	0.768333
Average Path Strength	7.61798	5.76054
Maximum Path Strength	20.085	18.4183
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.92698	0.926047
Maximum Path Correlation	1	0.99
Minimum % Of Corr. Nodes	4.7619	3.7037
Average % Of Corr. Nodes	55.0219	47.2682
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	40.618	42.8128
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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