psnGPCR

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Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	sst2_off Int. Strength	sst2_on Int. Strength	sst2_off Hub1?	sst2_on Hub1?	sst2_off Hub2?	sst2_on Hub2?	ConSurf1	ConSurf2
1	6x61	Lig	sst2_off	4.42	0	No	No	Yes	Yes	3	0
2	7x30	Lig	sst2_off	5.41	0	No	No	Yes	Yes	4	0
3	3x29	Lig	sst2_off	5.61	0	No	No	Yes	Yes	5	0
4	2x64	Lig	sst2_off	7.94	0	Yes	No	Yes	Yes	4	0
5	7x35	Lig	sst2_off	15.52	0	No	No	Yes	Yes	2	0
6	1x32	Lig	sst2_off	16.79	0	Yes	No	Yes	Yes	3	0
7	E1.E106	Lig	sst2_off	13.88	0	No	No	Yes	Yes	4	0
8	1x30	1x32	sst2_off	8.77	0	No	No	Yes	No	4	3
9	1x32	2x64	sst2_off	4.43	0	Yes	No	Yes	No	3	4
10	1x32	E1.E106	sst2_off	10.52	0	Yes	No	No	No	3	4
11	1x35	1x39	sst2_off	8.21	0	No	No	Yes	Yes	5	7
12	1x35	2x64	sst2_off	4.47	0	No	No	Yes	No	5	4
13	1x39	7x42	sst2_off	4.96	0	Yes	Yes	Yes	Yes	7	7
14	1x40	2x61	sst2_off	6.93	0	No	No	No	No	5	6
15	1x49	7x50	sst2_off	4.06	0	No	No	No	No	8	9
16	1x52	8x58	sst2_off	8.3	0	No	No	No	No	6	7
17	1x54	2x44	sst2_off	4.28	0	Yes	Yes	No	No	7	6
18	1x56	8x54	sst2_off	3.93	0	No	No	No	No	7	6
19	1x57	2x40	sst2_off	4.25	0	No	No	Yes	No	7	8
20	1x57	8x50	sst2_off	5.02	0	No	No	Yes	Yes	7	8
21	1x60	8x56	sst2_off	5.81	0	Yes	No	No	No	6	4
22	8x49	I1x49	sst2_off	6.99	0	No	No	No	No	5	5
23	2x40	I1x50	sst2_off	7.01	0	Yes	No	Yes	No	8	7
24	8x49	I1x50	sst2_off	8.41	0	No	No	Yes	No	5	7
25	8x50	I1x50	sst2_off	8.71	0	Yes	Yes	Yes	No	8	7
26	8x53	I1x50	sst2_off	6.13	0	No	No	Yes	No	5	7
27	2x38	I2x57	sst2_off	6.26	0	No	No	No	Yes	4	5
28	2x39	3x50	sst2_off	6.47	0	No	No	Yes	No	8	9
29	2x39	6x33	sst2_off	4.76	0	No	No	No	No	8	8
30	2x40	8x50	sst2_off	7.25	0	Yes	No	Yes	Yes	8	8
31	2x42	4x45	sst2_off	6.04	0	Yes	Yes	No	No	7	5
32	2x43	3x46	sst2_off	4.37	0	No	No	No	No	8	9
33	2x43	7x53	sst2_off	13.3	0	No	No	Yes	Yes	8	9
34	2x44	2x45	sst2_off	4.12	0	No	No	No	No	6	9
35	2x50	3x35	sst2_off	5.45	0	Yes	Yes	No	Yes	9	7
36	2x59	3x24	sst2_off	7.54	0	No	No	No	No	5	6
37	2x60	3x28	sst2_off	4.47	0	No	No	No	No	6	5
38	2x62	2x66	sst2_off	5.65	0	No	No	No	No	5	5
39	E1x49	E2.S191	sst2_off	5.58	0	No	No	No	No	4	5
40	3x22	E2.G182	sst2_off	5.23	0	No	No	No	No	3	5
41	3x34	3x38	sst2_off	7.6	0	No	No	Yes	No	5	7
42	3x34	4x50	sst2_off	4.7	0	No	No	Yes	No	5	9
43	3x35	7x46	sst2_off	5.96	0	No	Yes	No	No	7	8
44	3x36	6x52	sst2_off	7.89	0	Yes	Yes	Yes	No	7	7
45	3x37	3x41	sst2_off	4.29	0	Yes	No	No	No	6	6
46	3x37	4x57	sst2_off	5.02	0	Yes	No	No	No	6	7
47	3x37	5x461	sst2_off	4.52	0	Yes	No	No	No	6	6
48	3x40	6x44	sst2_off	16.33	0	No	No	Yes	No	8	9
49	3x43	6x40	sst2_off	5.96	0	No	No	No	No	9	8
50	3x44	5x54	sst2_off	6.08	0	No	No	Yes	No	7	7
51	3x46	6x37	sst2_off	7.61	0	No	No	No	No	9	8
52	3x49	3x50	sst2_off	4.76	0	No	No	Yes	No	8	9
53	3x50	6x33	sst2_off	3.92	0	Yes	No	No	No	9	8
54	3x50	6x34	sst2_off	11.64	0	Yes	No	No	No	9	7
55	3x50	6x37	sst2_off	3.92	0	Yes	No	No	No	9	8
56	3x54	6x30	sst2_off	5.7	0	No	No	Yes	Yes	8	6
57	I2x50	I2x51	sst2_off	5.08	0	No	No	No	No	8	5
58	4x40	4x43	sst2_off	7.43	0	No	No	No	No	4	1
59	4x57	4x62	sst2_off	8.75	0	No	No	No	No	7	5
60	4x60	5x42	sst2_off	4.17	0	No	No	No	No	8	4
61	4x61	E2x52	sst2_off	7.36	0	No	No	No	No	3	5
62	E2.N186	E2.Q187	sst2_off	3.96	0	No	No	No	No	1	2
63	E2.N186	E2.R190	sst2_off	6.03	0	No	No	No	No	1	1
64	5x34	E2.E200	sst2_off	6.03	0	No	No	No	No	1	4
65	5x36	5x40	sst2_off	6.04	0	Yes	Yes	No	No	4	5
66	5x36	6x58	sst2_off	5.09	0	Yes	Yes	No	No	4	4
67	5x44	6x56	sst2_off	6.55	0	No	No	No	No	5	5
68	5x51	5x54	sst2_off	4.28	0	No	No	Yes	No	6	7
69	5x54	6x41	sst2_off	4.61	0	Yes	No	No	No	7	7
70	5x58	6x38	sst2_off	7.63	0	No	Yes	No	No	9	4
71	5x65	6x26	sst2_off	10.46	0	No	No	No	Yes	8	4
72	6x23	6x24	sst2_off	4.89	0	No	No	No	No	3	2
73	6x26	6x31	sst2_off	13.61	0	No	Yes	No	No	4	5
74	6x27	6x29	sst2_off	4.59	0	No	No	No	No	3	5
75	6x30	6x34	sst2_off	7.06	0	Yes	Yes	No	No	6	7
76	6x39	7x56	sst2_off	7.14	0	No	No	No	No	6	6
77	6x44	7x45	sst2_off	4.83	0	Yes	No	Yes	No	9	9
78	6x46	6x47	sst2_off	4.19	0	No	No	No	No	6	8
79	6x48	6x51	sst2_off	5.01	0	Yes	Yes	Yes	No	8	6
80	6x48	6x52	sst2_off	8.68	0	Yes	Yes	Yes	No	8	7
81	6x51	6x52	sst2_off	8.25	0	Yes	No	Yes	No	6	7
82	6x51	7x37	sst2_off	3.93	0	Yes	No	No	No	6	7
83	6x51	7x41	sst2_off	5.19	0	Yes	No	No	No	6	7
84	7x31	E3.P286	sst2_off	6.69	0	No	No	No	No	3	2
85	7x38	7x42	sst2_off	5.05	0	No	No	Yes	Yes	6	7
86	7x41	7x42	sst2_off	4.99	0	No	No	Yes	Yes	7	7
87	7x53	8x50	sst2_off	8.25	0	Yes	Yes	Yes	Yes	9	8
88	8x47	8x50	sst2_off	13.14	0	No	No	Yes	Yes	8	8
89	8x52	8x63	sst2_off	5.75	0	No	No	No	No	5	3
90	8x55	8x63	sst2_off	4.07	0	No	No	No	No	4	3
91	8x56	8x63	sst2_off	9.79	0	No	No	No	No	4	3
92	1x60	8x53	sst2_off	3.82	0	Yes	No	No	No	6	5
93	1x53	7x53	sst2_off	3.79	0	No	No	Yes	Yes	9	9
94	1x55	8x57	sst2_off	3.79	0	No	No	Yes	No	3	5
95	E2.S192	Lig	sst2_off	3.74	0	No	No	Yes	Yes	4	0
96	1x40	2x62	sst2_off	3.73	0	No	No	No	No	5	5
97	1x31	Lig	sst2_off	3.72	0	No	No	Yes	Yes	4	0
98	3x43	6x44	sst2_off	3.65	0	No	No	Yes	No	9	9
99	3x51	5x61	sst2_off	3.63	0	Yes	Yes	No	No	8	9
100	6x36	7x53	sst2_off	3.59	0	No	No	Yes	Yes	8	9
101	3x51	3x52	sst2_off	3.52	0	Yes	Yes	No	No	8	4
102	1x53	2x47	sst2_off	3.39	0	No	No	No	No	9	9
103	E2.G182	E2.N196	sst2_off	3.39	0	No	No	No	No	5	3
104	1x30	1x33	sst2_off	3.36	0	No	No	No	No	4	4
105	2x49	3x38	sst2_off	3.36	0	No	No	Yes	No	8	7
106	3x48	5x57	sst2_off	3.27	0	No	No	No	No	6	7
107	3x29	4x65	sst2_off	3.22	0	No	No	No	No	5	4
108	1x36	2x64	sst2_off	3.17	0	No	Yes	Yes	No	5	4
109	3x27	3x30	sst2_off	3.17	0	No	No	No	No	5	6
110	1x52	8x57	sst2_off	2.98	0	No	No	Yes	No	6	5
111	8x57	8x58	sst2_off	2.98	0	Yes	No	No	No	5	7
112	6x43	7x45	sst2_off	2.96	0	No	No	Yes	No	7	9
113	5x40	5x41	sst2_off	2.94	0	No	No	No	No	5	5
114	E2.N196	E2x51	sst2_off	2.92	0	No	No	No	No	3	4
115	2x41	I1x51	sst2_off	2.91	0	No	No	No	No	5	7
116	2x54	2x57	sst2_off	2.83	0	No	No	No	Yes	6	7
117	5x35	E2.G199	sst2_off	2.81	0	Yes	Yes	No	No	3	3
118	3x26	4x65	sst2_off	2.77	0	No	No	No	No	6	4
119	4x55	4x59	sst2_off	2.77	0	No	No	No	No	3	4
120	7x54	8x54	sst2_off	2.77	0	No	No	No	No	7	6
121	6x27	6x30	sst2_off	2.7	0	No	No	Yes	Yes	3	6
122	8x55	8x61	sst2_off	2.66	0	No	No	No	No	4	4
123	2x53	3x31	sst2_off	2.62	0	Yes	Yes	No	No	6	5
124	5x44	5x48	sst2_off	2.44	0	No	No	No	No	5	4
125	7x36	7x40	sst2_off	2.44	0	No	No	No	No	5	7
126	2x52	4x50	sst2_off	2.28	0	No	No	Yes	No	7	9
127	E2.G189	E2.S185	sst2_off	1.86	0	No	No	No	No	6	2
128	5x32	5x33	sst2_off	1.86	0	No	No	No	No	2	2
129	3x33	4x61	sst2_off	1.76	0	No	No	No	No	4	3
130	7x31	7x32	sst2_off	1.74	0	No	No	No	No	3	1
131	1x42	7x47	sst2_off	1.71	0	No	No	No	No	7	8
132	3x42	4x49	sst2_off	1.71	0	No	No	No	No	8	6
133	4x51	4x54	sst2_off	1.71	0	No	No	No	No	4	3
134	2x38	4x39	sst2_off	1.69	0	No	No	No	No	4	3
135	2x41	4x39	sst2_off	1.69	0	No	No	No	No	5	3
136	3x38	3x42	sst2_off	1.69	0	Yes	No	No	No	7	8
137	5x64	I2x50	sst2_off	1.67	0	No	No	No	No	5	8
138	3x23	3x24	sst2_off	1.62	0	No	No	No	No	1	6
139	6x59	6x60	sst2_off	1.62	0	No	No	No	No	4	4
140	4x52	4x56	sst2_off	1.6	0	No	No	Yes	No	4	4
141	8x62	8x64	sst2_off	1.6	0	No	No	No	No	2	1
142	7x48	7x52	sst2_off	1.58	0	No	No	No	No	6	8
143	3x39	3x40	sst2_off	1.55	0	No	No	No	No	9	8
144	4x41	4x45	sst2_off	1.52	0	No	No	No	No	5	5
145	7x27	E3.I284	sst2_off	1.52	0	Yes	No	No	No	1	1
146	5x48	5x52	sst2_off	1.47	0	No	No	No	No	4	4
147	6x28	6x31	sst2_off	1.44	0	No	No	No	No	4	5
148	6x31	6x32	sst2_off	1.44	0	No	No	No	No	5	7
149	5x34	5x35	sst2_off	1.3	0	No	No	Yes	Yes	1	3
150	5x56	5x60	sst2_off	1.22	0	No	No	No	No	5	4
151	Lig	Lig	Shared	140.8	26.3125	Yes	Yes	Yes	Yes	0	0
152	5x36	Lig	Shared	23.28	10.91	Yes	Yes	Yes	Yes	4	0
153	6x54	Lig	Shared	9.52	5.1875	No	Yes	Yes	Yes	4	0
154	E3.P286	Lig	Shared	14.37	2.5675	No	No	Yes	Yes	2	0
155	7x31	Lig	Shared	14.25	3.805	No	No	Yes	Yes	3	0
156	7x34	Lig	Shared	17.11	13.015	No	No	Yes	Yes	4	0
157	E2x51	Lig	Shared	8.19	7.355	No	No	Yes	Yes	4	0
158	E2x52	Lig	Shared	7.93	4.415	No	No	Yes	Yes	5	0
159	3x32	Lig	Shared	11.06	7.865	No	No	Yes	Yes	6	0
160	3x36	Lig	Shared	8.14	10.7125	Yes	Yes	Yes	Yes	7	0
161	1x35	7x35	Shared	6.79	5.43	No	No	No	No	5	2
162	1x36	2x65	Shared	5.03	2.9375	No	Yes	No	No	5	5
163	1x37	1x41	Shared	6.55	3.605	No	No	No	No	6	5
164	1x39	2x61	Shared	4	2.6675	Yes	Yes	No	No	7	6
165	1x39	2x64	Shared	5.05	4.1	Yes	Yes	Yes	No	7	4
166	1x43	2x57	Shared	4.76	4.76	No	No	No	Yes	6	7
167	1x46	2x54	Shared	5.24	3.49	No	No	No	No	8	6
168	1x47	2x51	Shared	5.3	4.64	No	No	No	Yes	6	7
169	1x50	2x50	Shared	8.17	6.395	No	No	Yes	Yes	9	9
170	1x50	7x50	Shared	9.77	6.1125	No	No	No	No	9	9
171	1x51	2x51	Shared	8.47	2.115	No	No	No	Yes	5	7
172	1x54	2x48	Shared	5.89	3.31	Yes	Yes	No	No	7	7
173	1x54	2x51	Shared	5.47	2.05	Yes	Yes	No	Yes	7	7
174	1x55	1x59	Shared	16.46	6.1725	No	No	No	No	3	4
175	1x56	8x53	Shared	6.46	2.425	No	No	No	No	7	5
176	1x58	2x44	Shared	4.15	3.115	No	No	No	No	3	6
177	1x59	1x60	Shared	18.52	2.83	No	No	Yes	No	4	6
178	2x37	2x40	Shared	13.16	6.9475	No	No	Yes	No	7	8
179	2x42	3x45	Shared	10.09	5.365	Yes	Yes	No	No	7	7
180	2x42	3x46	Shared	4.79	4.79	Yes	Yes	No	No	7	9
181	2x45	4x46	Shared	14.62	10.6	No	No	No	No	9	7
182	2x45	4x50	Shared	6.78	4.52	No	No	Yes	No	9	9
183	2x50	7x46	Shared	10.43	9.2	Yes	Yes	No	No	9	8
184	2x50	7x49	Shared	4.09	7.7425	Yes	Yes	No	Yes	9	9
185	2x53	3x32	Shared	5.97	5.6725	Yes	Yes	No	No	6	6
186	2x53	3x35	Shared	21.75	4.83	Yes	Yes	No	Yes	6	7
187	2x53	7x42	Shared	12.38	17.535	Yes	Yes	Yes	Yes	6	7
188	2x57	7x42	Shared	4.69	9.0825	No	Yes	Yes	Yes	7	7
189	2x59	E1x52	Shared	12.86	6.7	No	No	Yes	Yes	5	6
190	2x59	3x28	Shared	3.93	4.2575	No	No	No	No	5	5
191	2x63	E1x50	Shared	10.95	5.4775	No	Yes	Yes	Yes	5	8
192	E1x49	E1x51	Shared	4.58	6.1	No	No	No	No	4	4
193	E1x49	E2.R190	Shared	5.64	12.1325	No	No	No	No	4	1
194	E1x50	E1x52	Shared	11.02	14.0275	Yes	Yes	Yes	Yes	8	6
195	3x25	E1x50	Shared	3.92	4.8975	No	No	Yes	Yes	9	8
196	E1x50	E2.L183	Shared	5.69	3.985	Yes	Yes	No	No	8	4
197	E1x50	E2x50	Shared	18.28	14.365	Yes	Yes	No	Yes	8	9
198	E1x51	E1x52	Shared	11.56	4.695	No	No	Yes	Yes	4	6
199	3x25	E2x50	Shared	7.28	6.37	No	No	No	Yes	9	9
200	3x29	E2x50	Shared	4.86	3.645	No	No	No	Yes	5	9
201	3x30	4x62	Shared	6.02	7.5275	No	No	No	No	6	5
202	3x32	7x42	Shared	4.6	8.62	No	No	Yes	Yes	6	7
203	3x36	3x37	Shared	10.54	3.805	Yes	Yes	Yes	No	7	6
204	3x36	6x48	Shared	7.67	7.395	Yes	Yes	Yes	Yes	7	8
205	3x37	4x56	Shared	9.18	5.57	Yes	No	Yes	No	6	4
206	3x38	4x50	Shared	9.7	17.585	Yes	No	Yes	No	7	9
207	3x38	4x53	Shared	9.59	5.5975	Yes	No	No	No	7	7
208	3x40	5x50	Shared	8.47	3.39	No	No	No	Yes	8	9
209	3x47	5x54	Shared	4.64	8.515	No	No	Yes	No	9	7
210	3x47	5x58	Shared	10.17	6.0425	No	No	No	Yes	9	9
211	3x49	I2x57	Shared	11.91	11.91	No	No	No	Yes	8	5
212	3x51	3x55	Shared	10.09	10.095	Yes	Yes	No	Yes	8	7
213	3x51	3x56	Shared	4.36	4.3575	Yes	Yes	No	Yes	8	5
214	3x51	5x57	Shared	4.03	7.39	Yes	Yes	No	No	8	7
215	3x51	5x60	Shared	4.13	6.705	Yes	Yes	No	No	8	4
216	3x52	I2x53	Shared	6.01	5.255	No	No	No	No	4	5
217	3x53	I2x57	Shared	6.91	5.53	No	No	No	Yes	8	5
218	3x54	5x61	Shared	4.61	6.53	No	No	No	No	8	9
219	3x55	3x56	Shared	9.69	6.2275	No	Yes	No	Yes	7	5
220	3x55	5x64	Shared	6.07	6.4525	No	Yes	No	No	7	5
221	4x38	4x39	Shared	12.97	2.52	No	Yes	No	No	6	3
222	4x56	5x42	Shared	6.31	3.1575	Yes	No	No	No	4	4
223	4x56	5x46	Shared	4.47	2.98	Yes	No	No	No	4	4
224	4x59	4x62	Shared	4.24	2.1225	No	No	No	No	4	5
225	4x63	4x64	Shared	8.46	9.9725	No	No	No	Yes	4	4
226	4x64	E2.W197	Shared	7.72	4.1	No	Yes	Yes	Yes	4	5
227	4x64	E2.P198	Shared	15.3	7.65	No	Yes	No	Yes	4	5
228	E2.Q187	E2.W188	Shared	19.71	1.9175	No	No	No	No	2	2
229	E2.W197	E2x52	Shared	15.27	4.9925	Yes	Yes	No	No	5	5
230	5x35	E2.W197	Shared	23.43	6.325	Yes	Yes	Yes	Yes	3	5
231	5x39	E2.W197	Shared	15.03	5.2625	No	Yes	Yes	Yes	7	5
232	5x35	E2.P198	Shared	12.16	8.7825	Yes	Yes	No	Yes	3	5
233	5x37	6x59	Shared	9.52	3.57	No	No	No	No	3	4
234	5x39	5x43	Shared	7.78	3.89	No	Yes	No	No	7	4
235	5x42	5x46	Shared	8.21	4.69	No	No	No	No	4	4
236	5x44	6x52	Shared	5.16	11.0925	No	No	Yes	No	5	7
237	5x47	5x51	Shared	7.31	3.96	No	Yes	No	No	8	6
238	5x47	6x49	Shared	8.53	5.785	No	Yes	No	Yes	8	5
239	5x47	6x52	Shared	20.63	4.1275	No	Yes	Yes	No	8	7
240	5x49	5x50	Shared	5.3	3.53	No	No	No	Yes	5	9
241	5x51	6x45	Shared	9.99	4.6375	No	No	No	No	6	6
242	5x59	5x60	Shared	6.09	0.61	No	No	No	No	4	4
243	5x59	5x63	Shared	4.28	1.4275	No	No	No	No	4	3
244	6x26	6x30	Shared	11.63	2.325	No	Yes	Yes	Yes	4	6
245	6x35	6x39	Shared	5.01	2.1925	No	No	No	No	6	6
246	6x36	7x56	Shared	5.65	2.4725	No	No	No	No	8	6
247	6x43	7x52	Shared	4.47	2.98	No	No	No	No	7	8
248	6x44	6x48	Shared	18.04	10.275	Yes	No	Yes	Yes	9	8
249	6x47	7x45	Shared	11.02	8.2675	No	No	Yes	No	8	9
250	6x48	7x41	Shared	18.19	8.49	Yes	Yes	No	No	8	7
251	6x48	7x45	Shared	6.78	8.1925	Yes	Yes	Yes	No	8	9
252	6x49	6x50	Shared	4.93	2.46	No	Yes	No	No	5	9
253	6x49	6x53	Shared	4.28	3.21	No	Yes	No	No	5	5
254	6x51	6x55	Shared	14.5	12.6875	Yes	No	No	No	6	6
255	6x54	7x33	Shared	9.95	2.49	No	Yes	No	No	4	4
256	6x54	7x34	Shared	13.93	5.09	No	Yes	No	No	4	4
257	7x27	7x30	Shared	5.9	5.8975	Yes	No	No	No	1	4
258	7x34	7x38	Shared	7.87	5.895	No	No	No	No	4	6
259	7x49	7x53	Shared	4.65	4.3625	No	Yes	Yes	Yes	9	9
260	8x47	8x49	Shared	4.04	1.8625	No	No	No	No	8	5
261	1x60	8x57	Shared	3.79	2.5225	Yes	No	Yes	No	6	5
262	1x43	2x58	Shared	3.77	3.2975	No	No	No	No	6	8
263	2x62	E1x52	Shared	3.73	5.6	No	No	Yes	Yes	5	6
264	E2.N196	E2.R184	Shared	3.62	2.11	No	No	No	No	3	2
265	E3.P286	E3.S285	Shared	3.56	4.45	No	No	No	No	2	2
266	7x27	7x28	Shared	3.5	3.0625	Yes	No	No	No	1	3
267	6x50	7x40	Shared	3.28	3.285	No	No	No	No	9	7
268	E2.S185	E2.S191	Shared	3.26	1.2225	No	No	No	No	2	5
269	1x54	2x47	Shared	3.25	1.625	Yes	Yes	No	No	7	9
270	2x41	4x42	Shared	3.25	4.06	No	No	No	No	5	7
271	4x38	4x40	Shared	3.2	1.3325	No	Yes	No	No	6	4
272	1x34	1x38	Shared	3.07	1.1525	No	No	No	No	5	5
273	1x38	7x39	Shared	3.07	1.9225	No	No	No	Yes	5	5
274	5x40	6x59	Shared	3.07	5.375	No	No	No	No	5	4
275	4x46	4x47	Shared	3.01	1.8825	No	No	No	No	7	4
276	3x48	5x53	Shared	2.94	2.94	No	No	No	Yes	6	6
277	5x41	5x45	Shared	2.94	2.205	No	No	No	No	5	4
278	1x47	2x54	Shared	2.83	2.8275	No	No	No	No	6	6
279	3x21	E1x50	Shared	2.81	1.405	No	No	Yes	Yes	7	8
280	1x47	2x55	Shared	2.77	1.035	No	No	No	No	6	5
281	2x46	2x50	Shared	2.75	5.7675	No	Yes	Yes	Yes	9	9
282	2x46	7x49	Shared	2.75	7.55	No	Yes	No	Yes	9	9
283	8x51	8x55	Shared	2.71	0.34	No	No	No	No	8	4
284	2x42	4x42	Shared	2.67	3.0025	Yes	Yes	No	No	7	7
285	1x39	7x39	Shared	2.52	9.1475	Yes	Yes	No	Yes	7	5
286	7x51	7x55	Shared	2.51	2.8275	No	No	No	Yes	6	7
287	4x41	I2x56	Shared	2.43	6.0625	No	No	No	No	5	3
288	2x56	2x58	Shared	2.03	2.03	No	No	No	No	6	8
289	1x46	7x47	Shared	1.96	2.94	No	No	No	No	8	8
290	1x48	1x49	Shared	1.96	3.92	No	No	No	No	5	8
291	3x33	4x57	Shared	1.76	3.5275	No	No	No	No	4	7
292	7x27	7x29	Shared	1.68	1.26	Yes	No	No	No	1	1
293	1x45	7x47	Shared	1.64	2.8625	No	No	No	No	4	8
294	I2x51	I2x52	Shared	1.45	0.3625	No	No	No	No	5	4
295	5x33	5x36	Shared	1.45	0.725	No	No	Yes	Yes	2	4
296	3x34	4x54	Shared	1.43	3.925	No	No	No	No	5	3
297	8x47	8x48	Shared	1.33	2.2075	No	No	No	No	8	5
298	6x58	Lig	sst2_on	0	2.9075	No	No	Yes	Yes	4	0
299	5x43	Lig	sst2_on	0	4.035	No	No	Yes	Yes	4	0
300	6x51	Lig	sst2_on	0	9.565	Yes	No	Yes	Yes	6	0
301	7x42	Lig	sst2_on	0	5.975	Yes	Yes	Yes	Yes	7	0
302	2x63	Lig	sst2_on	0	8.3825	No	Yes	Yes	Yes	5	0
303	1x39	2x57	sst2_on	0	5.5675	Yes	Yes	No	Yes	7	7
304	1x50	2x51	sst2_on	0	4.93	No	No	No	Yes	9	7
305	1x54	1x58	sst2_on	0	3.925	Yes	Yes	No	No	7	3
306	1x56	8x50	sst2_on	0	4.59	No	No	Yes	Yes	7	8
307	2x40	I1x49	sst2_on	0	5.245	Yes	No	No	No	8	5
308	2x37	2x39	sst2_on	0	4.3175	No	No	No	No	7	8
309	2x38	2x42	sst2_on	0	4.2325	No	No	Yes	Yes	4	7
310	2x41	4x43	sst2_on	0	3.27	No	No	No	No	5	1
311	2x42	3x49	sst2_on	0	10.3425	Yes	Yes	No	No	7	8
312	2x46	3x43	sst2_on	0	3.115	No	Yes	No	No	9	9
313	2x46	3x46	sst2_on	0	3.1775	No	Yes	No	No	9	9
314	2x50	3x39	sst2_on	0	4.4175	Yes	Yes	No	No	9	9
315	2x52	3x35	sst2_on	0	8.24	No	No	No	Yes	7	7
316	2x53	3x36	sst2_on	0	6.1475	Yes	Yes	Yes	Yes	6	7
317	2x53	7x46	sst2_on	0	4.29	Yes	Yes	No	No	6	8
318	2x57	2x58	sst2_on	0	3.2825	No	Yes	No	No	7	8
319	2x63	E2.S192	sst2_on	0	3.9725	No	Yes	No	No	5	4
320	2x63	E2x50	sst2_on	0	3.05	No	Yes	No	Yes	5	9
321	2x64	7x35	sst2_on	0	7.3	Yes	No	No	No	4	2
322	2x66	E1x49	sst2_on	0	7.07	No	No	No	No	5	4
323	E1.V106	E2.R190	sst2_on	0	2.945	No	No	No	No	0	1
324	3x24	E1x52	sst2_on	0	4.71	No	No	Yes	Yes	6	6
325	3x31	3x35	sst2_on	0	3.3275	No	No	No	Yes	5	7
326	3x34	4x53	sst2_on	0	4.255	No	No	No	No	5	7
327	3x40	6x48	sst2_on	0	7.34	No	No	Yes	Yes	8	8
328	3x41	4x49	sst2_on	0	3.6025	No	No	No	No	6	6
329	3x43	7x49	sst2_on	0	5.4925	No	No	No	Yes	9	9
330	3x43	7x53	sst2_on	0	8.205	No	No	Yes	Yes	9	9
331	3x44	5x50	sst2_on	0	3.5	No	No	No	Yes	7	9
332	3x44	5x53	sst2_on	0	3.04	No	No	No	Yes	7	6
333	3x45	4x45	sst2_on	0	3.07	No	No	No	No	7	5
334	3x46	7x53	sst2_on	0	3.89	No	No	Yes	Yes	9	9
335	3x50	5x58	sst2_on	0	6.685	Yes	No	No	Yes	9	9
336	3x50	7x53	sst2_on	0	6.945	Yes	No	Yes	Yes	9	9
337	4x38	4x41	sst2_on	0	2.91	No	Yes	No	No	6	5
338	4x57	4x61	sst2_on	0	5.52	No	No	No	No	7	3
339	4x59	4x60	sst2_on	0	2.8725	No	No	No	No	4	8
340	4x61	5x39	sst2_on	0	5.025	No	No	No	Yes	3	7
341	E2.L183	E2.S191	sst2_on	0	4.13	No	No	No	No	4	5
342	E2.N186	E2.W188	sst2_on	0	4.2375	No	No	No	No	1	2
343	E2.P198	E2.W197	sst2_on	0	3.715	No	Yes	Yes	Yes	5	5
344	5x36	E2.W197	sst2_on	0	5.0625	Yes	Yes	Yes	Yes	4	5
345	5x36	6x59	sst2_on	0	4.73	Yes	Yes	No	No	4	4
346	5x40	6x55	sst2_on	0	5.665	No	No	No	No	5	6
347	5x44	5x47	sst2_on	0	8.5725	No	No	No	Yes	5	8
348	5x52	5x56	sst2_on	0	2.95	No	No	No	No	4	5
349	5x54	5x58	sst2_on	0	4.535	Yes	No	No	Yes	7	9
350	5x58	6x37	sst2_on	0	12.305	No	Yes	No	No	9	8
351	5x62	6x34	sst2_on	0	4.18	No	Yes	No	No	5	7
352	5x64	5x68	sst2_on	0	3.825	No	No	No	No	5	0
353	5x66	6x30	sst2_on	0	11.1375	No	No	Yes	Yes	4	6
354	6x26	I3.G239	sst2_on	0	3	No	Yes	No	No	4	0
355	6x26	I3.I240	sst2_on	0	4.6975	No	Yes	No	No	4	0
356	6x23	6x26	sst2_on	0	3.295	No	No	No	Yes	3	4
357	6x45	6x49	sst2_on	0	3.565	No	No	No	Yes	6	5
358	6x50	7x37	sst2_on	0	3.0925	No	No	No	No	9	7
359	7x49	7x50	sst2_on	0	3.6675	No	Yes	No	No	9	9
360	7x52	7x53	sst2_on	0	3.2225	No	No	Yes	Yes	8	9
361	8x49	8x52	sst2_on	0	3.8475	No	No	No	No	5	5
362	4x43	I1x50	sst2_on	0	2.88	No	No	Yes	No	1	7
363	2x45	3x42	sst2_on	0	3.1475	No	No	No	No	9	8
364	I2x55	I2x56	sst2_on	0	4.35	No	No	No	No	4	3
365	E2.R184	E2.W197	sst2_on	0	4.25	No	No	Yes	Yes	2	5
366	E2.N186	E2.S192	sst2_on	0	3.725	No	No	No	No	1	4
367	5x35	5x39	sst2_on	0	3.7575	Yes	Yes	No	Yes	3	7
368	6x55	Lig	sst2_on	0	4.42	No	No	Yes	Yes	6	0
369	2x60	Lig	sst2_on	0	4.785	No	No	Yes	Yes	6	0
370	4x38	I2x57	sst2_on	0	5.33	No	Yes	No	Yes	6	5
371	7x45	7x49	sst2_on	0	3.4075	Yes	No	No	Yes	9	9
372	1x57	2x44	sst2_on	0	2.8525	No	No	No	No	7	6
373	4x65	E2x52	sst2_on	0	2.84	No	No	No	No	4	5
374	3x34	3x35	sst2_on	0	2.83	No	No	No	Yes	5	7
375	5x43	6x52	sst2_on	0	2.81	No	No	Yes	No	4	7
376	3x22	3x26	sst2_on	0	2.785	No	No	No	No	3	6
377	6x60	6x61	sst2_on	0	2.685	No	No	No	No	4	3
378	6x54	6x57	sst2_on	0	2.64	No	Yes	No	No	4	4
379	1x53	7x55	sst2_on	0	2.62	No	No	No	Yes	9	7
380	1x36	1x40	sst2_on	0	2.5925	No	Yes	No	No	5	5
381	1x57	I1x49	sst2_on	0	2.545	No	No	No	No	7	5
382	7x32	7x35	sst2_on	0	2.515	No	No	No	No	1	2
383	5x32	5x35	sst2_on	0	2.4725	No	No	Yes	Yes	2	3
384	2x40	I1x51	sst2_on	0	2.4475	Yes	No	No	No	8	7
385	8x54	8x58	sst2_on	0	2.4375	No	No	No	No	6	7
386	3x41	5x46	sst2_on	0	2.435	No	No	No	No	6	4
387	2x43	7x54	sst2_on	0	2.4325	No	No	No	No	8	7
388	7x54	8x50	sst2_on	0	2.4275	No	No	Yes	Yes	7	8
389	1x60	8x52	sst2_on	0	2.39	Yes	No	No	No	6	5
390	5x62	6x30	sst2_on	0	2.39	No	Yes	Yes	Yes	5	6
391	5x51	5x55	sst2_on	0	2.3775	No	No	No	No	6	5
392	5x62	6x33	sst2_on	0	2.305	No	Yes	No	No	5	8
393	6x41	6x45	sst2_on	0	2.305	No	No	No	No	7	6
394	3x41	4x52	sst2_on	0	2.2925	No	No	No	No	6	4
395	3x56	I2x52	sst2_on	0	2.2925	No	Yes	No	No	5	4
396	5x37	5x38	sst2_on	0	2.275	No	No	No	No	3	4
397	1x29	1x31	sst2_on	0	2.2525	No	No	No	No	0	4
398	4x64	E2.E200	sst2_on	0	2.245	No	Yes	No	No	4	4
399	8x50	I1x49	sst2_on	0	2.1725	Yes	Yes	No	No	8	5
400	6x31	6x35	sst2_on	0	2.165	No	No	No	No	5	6
401	8x50	8x54	sst2_on	0	2.145	Yes	Yes	No	No	8	6
402	6x39	7x52	sst2_on	0	2.1425	No	No	No	No	6	8
403	7x30	E3.I284	sst2_on	0	2.1425	No	No	No	No	4	1
404	4x59	4x63	sst2_on	0	2.14	No	No	No	No	4	4
405	3x56	I2x53	sst2_on	0	2.0925	No	Yes	No	No	5	5
406	1x57	I1x48	sst2_on	0	2.03	No	No	No	No	7	5
407	7x36	7x39	sst2_on	0	1.965	No	No	No	Yes	5	5
408	4x65	E2.G182	sst2_on	0	1.95	No	No	No	No	4	5
409	8x52	8x53	sst2_on	0	1.9125	No	No	No	No	5	5
410	6x40	7x53	sst2_on	0	1.89	No	No	Yes	Yes	8	9
411	1x40	1x44	sst2_on	0	1.885	No	No	No	No	5	4
412	1x29	1x30	sst2_on	0	1.8425	No	No	No	No	0	4
413	6x32	6x36	sst2_on	0	1.8	No	No	No	No	7	8
414	6x25	6x28	sst2_on	0	1.795	No	No	No	No	3	4
415	5x65	6x30	sst2_on	0	1.7825	No	No	Yes	Yes	8	6
416	1x53	7x50	sst2_on	0	1.77	No	No	No	No	9	9
417	3x22	E2.L183	sst2_on	0	1.7625	No	No	No	No	3	4
418	2x49	3x39	sst2_on	0	1.71	No	No	No	No	8	9
419	5x53	5x57	sst2_on	0	1.64	No	Yes	No	No	6	7
420	1x42	7x39	sst2_on	0	1.6025	No	No	No	Yes	7	5
421	5x62	6x37	sst2_on	0	1.5375	No	Yes	No	No	5	8
422	5x40	6x56	sst2_on	0	1.5375	No	No	No	No	5	5
423	3x55	5x61	sst2_on	0	1.5375	No	Yes	No	No	7	9
424	3x56	I2x50	sst2_on	0	1.53	No	Yes	No	No	5	8
425	1x52	7x55	sst2_on	0	1.5225	No	No	No	Yes	6	7
426	5x461	5x50	sst2_on	0	1.5225	No	No	No	Yes	6	9
427	6x54	7x30	sst2_on	0	1.5225	No	Yes	No	No	4	4
428	5x45	5x48	sst2_on	0	1.4275	No	No	No	No	4	4
429	4x50	4x51	sst2_on	0	1.41	Yes	No	No	No	9	4
430	1x36	1x37	sst2_on	0	1.2975	No	Yes	No	No	5	6
431	1x36	2x61	sst2_on	0	1.26	No	Yes	No	No	5	6
432	3x27	3x31	sst2_on	0	1.2	No	No	No	No	5	5
433	6x34	6x38	sst2_on	0	1.2	No	No	No	No	7	4
434	1x32	2x65	sst2_on	0	1.17	Yes	No	No	No	3	5
435	5x37	5x41	sst2_on	0	1.14	No	No	No	No	3	5
436	4x41	4x44	sst2_on	0	1.13	No	No	No	No	5	1
437	8x56	8x57	sst2_on	0	1.1075	No	No	Yes	No	4	5
438	6x28	6x32	sst2_on	0	1.0775	No	No	No	No	4	7
439	8x48	8x51	sst2_on	0	1.0375	No	No	No	No	5	8
440	I2x54	I2x57	sst2_on	0	1.0375	No	No	No	Yes	4	5
441	E2.G199	E2.P198	sst2_on	0	1.015	No	No	No	Yes	3	5
442	5x34	5x36	sst2_on	0	1	No	No	Yes	Yes	1	4
443	I3.G243	I3.V242	sst2_on	0	0.92	No	No	No	No	0	0
444	7x55	7x56	sst2_on	0	0.915	No	Yes	No	No	7	6
445	6x43	7x48	sst2_on	0	0.85	No	No	No	No	7	6
446	1x42	7x43	sst2_on	0	0.8475	No	No	No	No	7	5
447	6x23	I3.V242	sst2_on	0	0.8075	No	No	No	No	3	0
448	1x30	1x34	sst2_on	0	0.795	No	No	No	No	4	5
449	1x32	1x33	sst2_on	0	0.78	Yes	No	No	No	3	4
450	6x23	6x27	sst2_on	0	0.765	No	No	No	No	3	3
451	6x29	6x30	sst2_on	0	0.72	No	No	Yes	Yes	5	6
452	5x67	I3.R241	sst2_on	0	0.66	No	No	No	No	5	0
453	6x46	7x40	sst2_on	0	0.61	No	No	No	No	6	7
454	1x49	1x52	sst2_on	0	0.4275	No	No	No	No	8	6
455	E2.G189	E2.N186	sst2_on	0	0.425	No	No	No	No	6	1
456	5x52	5x53	sst2_on	0	0.38	No	No	No	Yes	4	6
457	6x61	E3.I284	sst2_on	0	0.365	No	No	No	No	3	1
458	5x68	I3.R241	sst2_on	0	0.33	No	No	No	No	0	0

Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	sst2_off Avg Int. Strength	sst2_on Avg Int. Strength	sst2_off Num Of Links	sst2_on Num Of Links	ConSurf
1	1x32	sst2_off	10.1275	0.975	4	2	3
2	1x60	sst2_off	7.985	2.58083	4	3	6
3	I1x50	sst2_off	7.565	2.88	4	1	7
4	2x40	sst2_off	7.9175	4.88	4	3	8
5	2x64	sst2_off	5.012	5.7	5	2	4
6	3x37	sst2_off	6.71	4.6875	5	2	6
7	3x38	sst2_off	6.388	11.5912	5	2	7
8	3x50	sst2_off	6.142	6.815	5	2	9
9	4x50	sst2_off	5.865	7.83833	4	3	9
10	4x56	sst2_off	5.39	3.9025	4	3	4
11	5x54	sst2_off	4.9025	6.525	4	2	7
12	6x44	sst2_off	10.7125	10.275	4	1	9
13	6x51	sst2_off	7.376	11.1263	5	2	6
14	6x52	sst2_off	10.122	6.01	5	3	7
15	7x27	sst2_off	3.15	3.40667	4	3	1
16	7x45	sst2_off	6.3975	6.6225	4	3	9
17	8x57	sst2_off	3.385	1.815	4	2	5
18	Lig	Shared	23.624	8.80708	20	18	0
19	1x39	Shared	4.948	5.37063	5	4	7
20	1x54	Shared	4.7225	2.7275	4	4	7
21	2x42	Shared	5.8975	5.5465	4	5	7
22	2x50	Shared	6.178	6.7045	5	5	9
23	2x53	Shared	10.68	7.695	4	5	6
24	E1x50	Shared	8.77833	7.35958	6	6	8
25	E1x52	Shared	9.7925	7.1465	4	5	6
26	3x36	Shared	8.56	7.015	4	4	7
27	3x51	Shared	4.96	7.13688	6	4	8
28	E2.W197	Shared	15.3625	4.81536	4	7	5
29	5x35	Shared	9.925	5.33437	4	4	3
30	5x36	Shared	8.965	4.4855	4	5	4
31	6x30	Shared	6.7725	3.671	4	5	6
32	6x48	Shared	10.7283	8.3385	6	5	8
33	7x42	Shared	6.11167	10.3031	6	4	7
34	7x53	Shared	6.716	4.7525	5	6	9
35	8x50	Shared	8.474	2.83375	5	4	8
36	1x36	sst2_on	4.1	2.02187	2	4	5
37	2x46	sst2_on	2.75	4.9025	2	4	9
38	2x51	sst2_on	6.41333	3.43375	3	4	7
39	2x57	sst2_on	4.09333	5.67313	3	4	7
40	2x63	sst2_on	10.95	5.22062	1	4	5
41	3x35	sst2_on	11.0533	4.80687	3	4	7
42	3x55	sst2_on	8.61667	6.07813	3	4	7
43	3x56	sst2_on	7.025	3.3	2	5	5
44	I2x57	sst2_on	8.36	5.95188	3	4	5
45	4x38	sst2_on	8.085	3.02313	2	4	6
46	4x64	sst2_on	10.4933	5.99187	3	4	4
47	E2x50	sst2_on	10.14	6.8575	3	4	9
48	E2.P198	sst2_on	13.73	5.29062	2	4	5
49	5x39	sst2_on	11.405	4.48375	2	4	7
50	5x47	sst2_on	12.1567	5.61125	3	4	8
51	5x50	sst2_on	6.885	2.98563	2	4	9
52	5x53	sst2_on	2.94	2	1	4	6
53	5x58	sst2_on	8.9	7.39188	2	4	9
54	5x62	sst2_on	0	2.60313	0	4	5
55	6x26	sst2_on	11.9	3.32938	3	4	4
56	6x49	sst2_on	5.91333	3.755	3	4	5
57	6x54	sst2_on	11.1333	3.386	3	5	4
58	7x39	sst2_on	2.795	3.65937	2	4	5
59	7x49	sst2_on	3.83	5.37042	3	6	9
60	7x55	sst2_on	2.51	1.97125	1	4	7

Orange: nodes, hubs and links specific of sst2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	sst2_off Recurrence	sst2_on Recurrence	sst2_off Hub1?	sst2_on Hub1?	sst2_off Hub2?	sst2_on Hub2?	ConSurf1	ConSurf2
1	3x32	7x42	sst2_off	12.8538	0.101344	No	No	Yes	Yes	6	7
2	1x40	2x61	sst2_off	15.6996	0	No	No	No	No	5	6
3	2x54	2x57	sst2_off	26.8775	0	No	No	No	Yes	6	7
4	1x47	2x54	sst2_off	24.5059	8.77937	No	No	No	No	6	6
5	2x50	3x35	sst2_off	98.3294	0	Yes	Yes	No	Yes	9	7
6	1x60	8x53	sst2_off	21.2332	0	Yes	No	No	No	6	5
7	8x53	I1x50	sst2_off	27.4519	0	No	No	Yes	No	5	7
8	8x50	I1x50	sst2_off	31.4677	0	Yes	Yes	Yes	No	8	7
9	7x53	8x50	sst2_off	43.3465	0	Yes	Yes	Yes	Yes	9	8
10	1x54	2x44	sst2_off	23.0777	0	Yes	Yes	No	No	7	6
11	3x50	6x37	sst2_off	50.5982	0	Yes	No	No	No	9	8
12	3x46	6x37	sst2_off	51.942	0	No	No	No	No	9	8
13	2x43	3x46	sst2_off	70.498	0	No	No	No	No	8	9
14	2x43	7x53	sst2_off	71.6574	0	No	No	Yes	Yes	8	9
15	2x41	4x42	sst2_off	10.8037	8.65551	No	No	No	No	5	7
16	2x44	2x45	sst2_off	20.137	0	No	No	No	No	6	9
17	2x45	4x50	sst2_off	15.6469	8.02868	No	No	Yes	No	9	9
18	E1x50	E2x50	sst2_off	22.5982	0.123865	Yes	Yes	No	Yes	8	9
19	3x29	E2x50	sst2_off	24.9697	1.66654	No	No	No	Yes	5	9
20	3x29	Lig	sst2_off	28.4163	0	No	No	Yes	Yes	5	0
21	1x40	2x62	sst2_off	14.3452	0	No	No	No	No	5	5
22	2x62	E1x52	sst2_off	12.4796	1.86923	No	No	Yes	Yes	5	6
23	E1x49	E1x51	sst2_off	15.3412	7.44314	No	No	No	No	4	4
24	E1x51	E1x52	sst2_off	17.2121	9.28609	No	No	Yes	Yes	4	6
25	3x36	3x37	sst2_off	21.1014	9.39869	Yes	Yes	Yes	No	7	6
26	3x36	6x52	sst2_off	21.5758	0	Yes	Yes	Yes	No	7	7
27	5x51	5x54	sst2_off	15.9631	0	No	No	Yes	No	6	7
28	5x47	5x51	sst2_off	21.2016	7.17288	No	Yes	No	No	8	6
29	3x50	6x34	sst2_off	42.1449	0	Yes	No	No	No	9	7
30	3x51	5x61	sst2_off	26.0501	0	Yes	Yes	No	No	8	9
31	3x54	5x61	sst2_off	27.473	1.45635	No	No	No	No	8	9
32	3x54	6x30	sst2_off	28.996	0	No	No	Yes	Yes	8	6
33	6x30	6x34	sst2_off	40.7378	0	Yes	Yes	No	No	6	7
34	5x44	6x52	sst2_off	10.6825	1.77164	No	No	Yes	No	5	7
35	6x51	6x52	sst2_off	15.4677	0	Yes	No	Yes	No	6	7
36	6x48	7x41	sst2_off	26.8722	1.45635	Yes	Yes	No	No	8	7
37	7x41	7x42	sst2_off	43.5731	0	No	No	Yes	Yes	7	7
38	1x53	7x53	sst2_off	14.7036	0	No	No	Yes	Yes	9	9
39	1x53	2x47	sst2_off	13.3281	0	No	No	No	No	9	9
40	1x54	2x47	sst2_off	13.5494	2.20329	Yes	Yes	No	No	7	9
41	1x39	7x42	sst2_off	21.8287	0	Yes	Yes	Yes	Yes	7	7
42	6x51	7x41	sst2_off	16.2108	0	Yes	No	No	No	6	7
43	6x48	6x52	sst2_off	15.1146	0	Yes	Yes	Yes	No	8	7
44	1x39	2x61	Shared	17.0646	11.6846	Yes	Yes	No	No	7	6
45	3x32	Lig	Shared	68.39	33.0193	No	No	Yes	Yes	6	0
46	2x57	7x42	Shared	32.0843	32.6252	No	Yes	Yes	Yes	7	7
47	1x47	2x51	Shared	23.5152	13.1259	No	No	No	Yes	6	7
48	2x53	3x35	Shared	100	27.5843	Yes	Yes	No	Yes	6	7
49	2x53	3x32	Shared	55.7576	33.1844	Yes	Yes	No	No	6	6
50	7x49	7x53	Shared	94.9249	41.84	No	Yes	Yes	Yes	9	9
51	2x50	7x49	Shared	94.946	16.6466	Yes	Yes	No	Yes	9	9
52	1x54	2x51	Shared	22.6087	60.3896	Yes	Yes	No	Yes	7	7
53	2x42	4x42	Shared	12.2951	11.6771	Yes	Yes	No	No	7	7
54	2x42	3x46	Shared	20.0949	56.1031	Yes	Yes	No	No	7	9
55	E1x50	E1x52	Shared	17.9341	18.3883	Yes	Yes	Yes	Yes	8	6
56	3x36	Lig	Shared	43.5731	87.5084	Yes	Yes	Yes	Yes	7	0
57	3x36	6x48	Shared	11.2938	59.744	Yes	Yes	Yes	Yes	7	8
58	5x47	6x52	Shared	36.664	23.0763	No	Yes	Yes	No	8	7
59	E2x52	Lig	Shared	18.1924	27.7194	No	No	Yes	Yes	5	0
60	E2.W197	E2x52	Shared	15.1673	23.0351	Yes	Yes	No	No	5	5
61	5x36	Lig	Shared	13.6812	37.8087	Yes	Yes	Yes	Yes	4	0
62	5x47	6x49	Shared	13.3281	14.3045	No	Yes	No	Yes	8	5
63	2x53	7x42	Shared	45.6495	50.4842	Yes	Yes	Yes	Yes	6	7
64	5x36	E2.W197	sst2_on	0	23.4967	Yes	Yes	Yes	Yes	4	5
65	1x39	2x57	sst2_on	0	28.0459	Yes	Yes	No	Yes	7	7
66	7x42	Lig	sst2_on	0	48.0782	Yes	Yes	Yes	Yes	7	0
67	1x36	2x61	sst2_on	0	10.4159	No	Yes	No	No	5	6
68	1x39	7x39	sst2_on	4.8643	11.3768	Yes	Yes	No	Yes	7	5
69	1x50	2x51	sst2_on	0	76.0641	No	No	No	Yes	9	7
70	1x50	2x50	sst2_on	6.74045	69.5668	No	No	Yes	Yes	9	9
71	2x50	7x46	sst2_on	0.57971	98.8815	Yes	Yes	No	No	9	8
72	2x53	7x46	sst2_on	0	100	Yes	Yes	No	No	6	8
73	2x53	3x36	sst2_on	0	41.0742	Yes	Yes	Yes	Yes	6	7
74	1x53	7x55	sst2_on	0	13.3473	No	No	No	Yes	9	7
75	1x53	7x50	sst2_on	0	14.6573	No	No	No	No	9	9
76	7x49	7x50	sst2_on	0	20.9181	No	Yes	No	No	9	9
77	7x45	7x49	sst2_on	0	56.1857	Yes	No	No	Yes	9	9
78	6x48	7x45	sst2_on	8.04216	56.6211	Yes	Yes	Yes	No	8	9
79	1x54	1x58	sst2_on	0	54.3991	Yes	Yes	No	No	7	3
80	1x56	8x50	sst2_on	0	27.0475	No	No	Yes	Yes	7	8
81	8x50	I1x49	sst2_on	0	36.5626	Yes	Yes	No	No	8	5
82	1x57	I1x49	sst2_on	0	46.2878	No	No	No	No	7	5
83	1x57	2x44	sst2_on	0	50.3678	No	No	No	No	7	6
84	1x58	2x44	sst2_on	1.60738	52.3872	No	No	No	No	3	6
85	2x46	3x46	sst2_on	0	44.6551	No	Yes	No	No	9	9
86	2x46	2x50	sst2_on	1.14361	34.0402	No	Yes	Yes	Yes	9	9
87	2x46	7x49	sst2_on	0.55863	13.0245	No	Yes	No	Yes	9	9
88	3x46	7x53	sst2_on	0	14.4584	No	No	Yes	Yes	9	9
89	2x42	3x49	sst2_on	0	33.0643	Yes	Yes	No	No	7	8
90	3x38	4x50	sst2_on	7.87352	11.9999	Yes	No	Yes	No	7	9
91	3x38	4x53	sst2_on	1.60738	13.9742	Yes	No	No	No	7	7
92	3x34	4x53	sst2_on	0	15.941	No	No	No	No	5	7
93	3x34	3x35	sst2_on	0	19.8521	No	No	No	Yes	5	7
94	2x63	E1x50	sst2_on	1.44928	32.4262	No	Yes	Yes	Yes	5	8
95	2x63	Lig	sst2_on	0	47.5865	No	Yes	Yes	Yes	5	0
96	4x59	4x63	sst2_on	0	13.809	No	No	No	No	4	4
97	4x63	4x64	sst2_on	1.45455	17.2435	No	No	No	Yes	4	4
98	4x64	E2.W197	sst2_on	4.25823	23.9847	No	Yes	Yes	Yes	4	5
99	3x40	6x48	sst2_on	0	36.6039	No	No	Yes	Yes	8	8
100	3x40	5x50	sst2_on	2.8195	35.3389	No	No	No	Yes	8	9
101	3x44	5x50	sst2_on	0	31.4991	No	No	No	Yes	7	9
102	3x44	5x53	sst2_on	0	30.2042	No	No	No	Yes	7	6
103	3x50	5x58	sst2_on	0	22.4232	Yes	No	No	Yes	9	9
104	3x50	7x53	sst2_on	0	23.4067	Yes	No	Yes	Yes	9	9
105	3x49	I2x57	sst2_on	5.86561	30.0991	No	No	No	Yes	8	5
106	3x51	5x57	sst2_on	5.08564	23.6168	Yes	Yes	No	No	8	7
107	5x53	5x57	sst2_on	0	24.9493	No	Yes	No	No	6	7
108	4x38	4x41	sst2_on	0	12.1275	No	Yes	No	No	6	5
109	4x38	I2x57	sst2_on	0	21.1471	No	Yes	No	Yes	6	5
110	5x36	6x59	sst2_on	0	10.9414	Yes	Yes	No	No	4	4
111	5x43	Lig	sst2_on	0	36.5363	No	No	Yes	Yes	4	0
112	5x43	6x52	sst2_on	0	26.5708	No	No	Yes	No	4	7
113	5x58	6x37	sst2_on	0	19.1314	No	Yes	No	No	9	8
114	5x62	6x37	sst2_on	0	17.9416	No	Yes	No	No	5	8
115	5x62	6x30	sst2_on	0	13.3323	No	Yes	Yes	Yes	5	6
116	6x54	Lig	sst2_on	2.70883	17.4386	No	Yes	Yes	Yes	4	0
117	6x54	7x30	sst2_on	0	12.5178	No	Yes	No	No	4	4
118	1x56	8x53	sst2_on	5.08564	24.9531	No	No	No	No	7	5
119	8x52	8x53	sst2_on	0	22.8286	No	No	No	No	5	5
120	8x49	8x52	sst2_on	0	10.6073	No	No	No	No	5	5
121	1x60	8x52	sst2_on	0	10.2432	Yes	No	No	No	6	5
122	5x39	5x43	sst2_on	1.43874	10.8438	No	Yes	No	No	7	4
123	1x50	7x50	sst2_on	5.06983	12.7093	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
5x36	Lig	Shared	23.28	10.91	1	1	1	0
6x54	Lig	Shared	9.52	5.1875	1	1	1	0
6x61	Lig	sst2_off	4.42	0	0	0	1	0
E3.P286	Lig	Shared	14.37	2.5675	1	1	1	0
7x30	Lig	sst2_off	5.41	0	1	0	1	0
7x31	Lig	Shared	14.25	3.805	1	0	1	0
7x34	Lig	Shared	17.11	13.015	1	1	1	0
3x29	Lig	sst2_off	5.61	0	1	0	1	0
E2x51	Lig	Shared	8.19	7.355	1	0	1	0
E2x52	Lig	Shared	7.93	4.415	1	1	1	0
3x32	Lig	Shared	11.06	7.865	1	1	1	0
3x36	Lig	Shared	8.14	10.7125	1	1	1	0
2x64	Lig	sst2_off	7.94	0	1	0	1	0
7x35	Lig	sst2_off	15.52	0	1	0	1	0
1x32	Lig	sst2_off	16.79	0	1	0	1	0
E1.E106	Lig	sst2_off	13.88	0	1	0	1	0
1x30	1x32	sst2_off	8.77	0	0	0	2	1
1x32	2x64	sst2_off	4.43	0	1	0	1	1
1x32	E1.E106	sst2_off	10.52	0	1	0	1	1
1x35	1x39	sst2_off	8.21	0	1	0	2	2
1x35	2x64	sst2_off	4.47	0	1	0	2	1
1x35	7x35	Shared	6.79	5.43	1	0	2	1
1x36	2x65	Shared	5.03	2.9375	0	0	2	2
1x39	2x64	Shared	5.05	4.1	1	0	2	1
1x39	7x42	sst2_off	4.96	0	1	0	2	1
2x53	3x32	Shared	5.97	5.6725	1	1	2	1
2x53	7x42	Shared	12.38	17.535	1	1	2	1
2x57	7x42	Shared	4.69	9.0825	0	1	2	1
2x60	3x28	sst2_off	4.47	0	0	0	1	2
2x63	E1x50	Shared	10.95	5.4775	0	1	1	2
E1x50	E2x50	Shared	18.28	14.365	1	1	2	2
3x29	E2x50	Shared	4.86	3.645	1	0	1	2
3x32	7x42	Shared	4.6	8.62	1	1	1	1
3x36	3x37	Shared	10.54	3.805	1	1	1	2
3x36	6x48	Shared	7.67	7.395	1	1	1	2
3x36	6x52	sst2_off	7.89	0	1	1	1	2
4x61	E2x52	sst2_off	7.36	0	0	0	2	1
E2.W197	E2x52	Shared	15.27	4.9925	0	1	2	1
5x39	E2.W197	Shared	15.03	5.2625	0	1	2	2
5x36	5x40	sst2_off	6.04	0	1	1	1	2
5x36	6x58	sst2_off	5.09	0	1	1	1	1
5x39	5x43	Shared	7.78	3.89	0	1	2	1
6x48	6x51	sst2_off	5.01	0	1	0	2	1
6x48	6x52	sst2_off	8.68	0	1	0	2	2
6x48	7x41	Shared	18.19	8.49	1	0	2	2
6x51	6x52	sst2_off	8.25	0	1	1	1	2
6x51	6x55	Shared	14.5	12.6875	1	1	1	1
6x51	7x37	sst2_off	3.93	0	1	1	1	2
6x51	7x41	sst2_off	5.19	0	1	1	1	2
6x54	7x33	Shared	9.95	2.49	1	1	1	2
6x54	7x34	Shared	13.93	5.09	1	1	1	1
7x31	E3.P286	sst2_off	6.69	0	1	0	1	1
7x27	7x30	Shared	5.9	5.8975	0	0	2	1
7x34	7x38	Shared	7.87	5.895	1	1	1	2
7x38	7x42	sst2_off	5.05	0	0	0	2	1
7x41	7x42	sst2_off	4.99	0	1	0	2	1
E2.S192	Lig	sst2_off	3.74	0	0	0	1	0
1x31	Lig	sst2_off	3.72	0	0	0	1	0
E3.P286	E3.S285	Shared	3.56	4.45	1	1	1	2
1x30	1x33	sst2_off	3.36	0	0	0	2	2
3x29	4x65	sst2_off	3.22	0	1	0	1	2
1x36	2x64	sst2_off	3.17	0	0	0	2	1
5x40	6x59	Shared	3.07	5.375	0	0	2	2
E2.N196	E2x51	sst2_off	2.92	0	0	0	2	1
7x31	7x32	sst2_off	1.74	0	1	0	1	2
6x59	6x60	sst2_off	1.62	0	0	0	2	2
7x27	E3.I284	sst2_off	1.52	0	0	0	2	2
5x33	5x36	Shared	1.45	0.725	0	0	2	1
6x58	Lig	sst2_on	0	2.9075	0	0	1	0
5x43	Lig	sst2_on	0	4.035	0	1	1	0
6x51	Lig	sst2_on	0	9.565	1	1	1	0
7x42	Lig	sst2_on	0	5.975	1	1	1	0
2x63	Lig	sst2_on	0	8.3825	0	1	1	0
1x39	2x57	sst2_on	0	5.5675	1	0	2	2
2x53	3x36	sst2_on	0	6.1475	1	1	2	1
2x63	E2.S192	sst2_on	0	3.9725	0	1	1	1
2x63	E2x50	sst2_on	0	3.05	0	1	1	2
2x64	7x35	sst2_on	0	7.3	1	0	1	1
4x61	5x39	sst2_on	0	5.025	0	0	2	2
5x36	E2.W197	sst2_on	0	5.0625	1	1	1	2
5x36	6x59	sst2_on	0	4.73	1	1	1	2
5x40	6x55	sst2_on	0	5.665	0	0	2	1
E2.N186	E2.S192	sst2_on	0	3.725	0	0	2	1
6x55	Lig	sst2_on	0	4.42	0	1	1	0
2x60	Lig	sst2_on	0	4.785	0	0	1	0
4x65	E2x52	sst2_on	0	2.84	0	0	2	1
5x43	6x52	sst2_on	0	2.81	0	1	1	2
6x60	6x61	sst2_on	0	2.685	0	0	2	1
6x54	6x57	sst2_on	0	2.64	1	1	1	2
7x32	7x35	sst2_on	0	2.515	0	0	2	1
1x29	1x31	sst2_on	0	2.2525	0	0	2	1
7x30	E3.I284	sst2_on	0	2.1425	1	0	1	2
1x29	1x30	sst2_on	0	1.8425	0	0	2	2
6x54	7x30	sst2_on	0	1.5225	1	1	1	1
1x32	2x65	sst2_on	0	1.17	1	0	1	2
5x34	5x36	sst2_on	0	1	0	0	2	1
1x32	1x33	sst2_on	0	0.78	1	0	1	2
6x61	E3.I284	sst2_on	0	0.365	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	sst2_off	7XNA-SST2-CYN154806
	sst2_on	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2

Network Difference
Value	sst2_off	sst2_on
I_min	3.92	2.8675
Number of Linked Nodes	270	283
Number of Specific Nodes	8 (2.96%)	21 (7.42%)
Number of Shared Nodes	262 (97.04%)	262 (92.58%)
Number of Links	297	308
Number of Specific Links	150 (50.51%)	161 (52.27%)
Number of Shared Links	147 (49.49%)	147 (47.73%)
Number of Hubs	35	43
Number of Specific Hubs	17 (48.57%)	25 (58.14%)
Number of Shared Hubs	18 (51.43%)	18 (41.86%)
Average % Shared Neighbours (Jaccard)	33.30
Average % Shared Neighbours (Otsuka)	42.56
Average % Shared Neighbours (Overlap Coefficient)	52.21
Average % Shared Cliques (k3-6)	79.84
Graphlets Similarity	0.594682

Paths Difference
Value	sst2_off	sst2_on
Number Of Nodes in MetaPath	58	74
Specific Nodes in MetaPath	21 (36.21%)	37 (50.00%)
Shared Nodes in MetaPath	262 (97.04%)	262 (97.04%)
Number Of Links MetaPath	63	80
Specific Links in MetaPath	43 (68.25%)	60 (75.00%)
Shared Links in MetaPath	147 (49.49%)	147 (49.49%)
Number of Shortest Paths	42825	70654
Length Of Smallest Path	3	3
Average Path Length	12.6834	13.0344
Length of Longest Path	31	31
Minimum Path Strength	1.44	0.495
Average Path Strength	7.6636	5.43032
Maximum Path Strength	20.035	14.1963
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.92733	0.919152
Maximum Path Correlation	1	0.99
Minimum % Of Corr. Nodes	4.7619	3.57143
Average % Of Corr. Nodes	54.8705	45.5258
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	41.5104	50.6827
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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