Orange: nodes, hubs and links specific of sst2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner sst2_on_gp Avg Int. Strength sst2_off Avg Int. Strength sst2_on_gp Num Of Links sst2_off Num Of Links ConSurf
11x36 sst2_on_gp2.021874.1425
22x46 sst2_on_gp4.90252.75429
32x51 sst2_on_gp3.433756.41333437
42x57 sst2_on_gp5.673134.09333437
52x63 sst2_on_gp5.2206210.95415
63x35 sst2_on_gp4.8068711.0533437
73x56 sst2_on_gp3.74257.025425
8I2x57 sst2_on_gp5.951888.36435
94x38 sst2_on_gp3.1168.085526
104x64 sst2_on_gp5.9918710.4933434
11E2x50 sst2_on_gp6.857510.14439
12E2x52 sst2_on_gp3.710.1867435
13E2.P198 sst2_on_gp5.2906213.73425
145x39 sst2_on_gp4.4837511.405427
155x43 sst2_on_gp3.331887.78414
165x46 sst2_on_gp3.135626.34424
175x47 sst2_on_gp5.6112512.1567438
185x50 sst2_on_gp2.985636.885429
195x51 sst2_on_gp3.35257.19333436
205x58 sst2_on_gp7.391888.9429
216x26 sst2_on_gp3.497511.9534
226x49 sst2_on_gp3.7555.91333435
236x54 sst2_on_gp3.38611.1333534
247x39 sst2_on_gp3.659372.795425
257x49 sst2_on_gp5.370423.83639
267x50 sst2_on_gp3.491256.915429
27G.HN.47 sst2_on_gp3.099380406
28G.S1.02 sst2_on_gp4.905630405
29G.H1.01 sst2_on_gp3.20750509
30G.S2.08 sst2_on_gp6.438750405
31G.S3.01 sst2_on_gp4.580404
32G.S3.03 sst2_on_gp7.50550507
33G.S3.04 sst2_on_gp7.363750406
34G.S3.06 sst2_on_gp7.5750505
35G.s3h2.03 sst2_on_gp3.63950509
36G.H2.04 sst2_on_gp3.133120409
37G.H2.06 sst2_on_gp5.0460509
38G.H2.07 sst2_on_gp4.215420609
39G.H2.09 sst2_on_gp5.748130408
40G.h2s4.01 sst2_on_gp5.20250609
41G.S4.04 sst2_on_gp5.5850409
42G.s4h3.04 sst2_on_gp4.644580608
43G.s4h3.05 sst2_on_gp5.978130409
44G.s4h3.08 sst2_on_gp1.996250408
45G.H3.02 sst2_on_gp3.955630408
46G.H3.09 sst2_on_gp4.75750709
47G.H3.13 sst2_on_gp3.87250405
48G.H3.18 sst2_on_gp4.84750409
49G.S5.03 sst2_on_gp3.80408
50G.S5.05 sst2_on_gp4.179370409
51G.S5.07 sst2_on_gp3.6440509
52G.HG.03 sst2_on_gp3.565620406
53G.HG.04 sst2_on_gp4.073750409
54G.HG.13 sst2_on_gp4.2050407
55G.hgh4.02 sst2_on_gp4.930310807
56G.H4.15 sst2_on_gp3.611250408
57G.H4.16 sst2_on_gp4.670620403
58G.h4s6.12 sst2_on_gp7.463750404
59G.S6.02 sst2_on_gp6.453570707
60G.H5.03 sst2_on_gp4.965620408
61G.H5.08 sst2_on_gp3.48050508
62G.H5.16 sst2_on_gp2.90406
63G.H5.20 sst2_on_gp4.015620409
64G.H5.26 sst2_on_gp3.6140505
65b.1x4 sst2_on_gp2.796250408
66b.1x11 sst2_on_gp2.805620408
67b.lh12x2 sst2_on_gp4.609380408
68b.lhb1x11 sst2_on_gp3.14950504
69b.b1x4 sst2_on_gp4.361250407
70b.l1x3 sst2_on_gp7.612920609
71b.b2x1 sst2_on_gp5.97950508
72b.b2x5 sst2_on_gp6.1050607
73b.l3x2 sst2_on_gp3.8350509
74b.b4x4 sst2_on_gp8.264380408
75b.b4x5 sst2_on_gp4.371880407
76b.b4x6 sst2_on_gp9.534580609
77b.b5x2 sst2_on_gp5.450407
78b.b5x3 sst2_on_gp6.417860709
79b.b5x5 sst2_on_gp5.303750405
80b.b5x7 sst2_on_gp5.329380407
81b.l5x1 sst2_on_gp3.823750408
82b.l5x5 sst2_on_gp7.026790709
83b.b6x5 sst2_on_gp3.182920606
84b.l6x5 sst2_on_gp5.444380404
85b.b7x1 sst2_on_gp5.74550504
86b.l7x2 sst2_on_gp3.923130409
87b.b8x3 sst2_on_gp3.81250406
88b.b8x4 sst2_on_gp4.227080606
89b.l8x3 sst2_on_gp5.12250403
90b.l8x5 sst2_on_gp5.776250403
91b.l8x8 sst2_on_gp4.738750404
92b.l9x3 sst2_on_gp5.992860709
93b.l9x6 sst2_on_gp4.254440908
94b.l9x7 sst2_on_gp3.169370407
95b.b10x2 sst2_on_gp3.321250406
96b.b10x5 sst2_on_gp3.75750709
97b.l10x1 sst2_on_gp4.1650403
98b.b11x4 sst2_on_gp4.3160509
99b.b11x5 sst2_on_gp3.798750406
100b.b11x6 sst2_on_gp7.60250409
101b.l11x2 sst2_on_gp7.710509
102b.b12x5 sst2_on_gp3.131880406
103b.b12x6 sst2_on_gp6.485710708
104b.b13x7 sst2_on_gp7.80507
105b.l13x3 sst2_on_gp7.6640509
106b.l13x7 sst2_on_gp4.701870409
107b.b14x1 sst2_on_gp4.070408
108b.b14x3 sst2_on_gp3.718750405
109b.b15x1 sst2_on_gp6.3830509
110b.b15x2 sst2_on_gp5.11250506
111b.b15x3 sst2_on_gp3.6660509
112b.l15x1 sst2_on_gp5.21250407
113b.l15x2 sst2_on_gp4.49850509
114b.b16x4 sst2_on_gp8.488750406
115b.b16x5 sst2_on_gp3.5750405
116b.b16x6 sst2_on_gp9.46550508
117b.b17x7 sst2_on_gp5.95050508
118b.l17x3 sst2_on_gp7.910420609
119b.b18x3 sst2_on_gp4.38850508
120b.b18x5 sst2_on_gp6.028120405
121b.l18x1 sst2_on_gp5.777860706
122b.l18x2 sst2_on_gp5.31750407
123b.b19x2 sst2_on_gp5.625360706
124b.b19x4 sst2_on_gp5.3350408
125b.l19x2 sst2_on_gp6.98950509
126b.b20x4 sst2_on_gp6.765830608
127b.b20x5 sst2_on_gp3.916870407
128b.b20x6 sst2_on_gp7.5610506
129b.b21x1 sst2_on_gp7.69250507
130b.b21x5 sst2_on_gp4.3410504
131b.b21x7 sst2_on_gp5.5250605
132b.l21x2 sst2_on_gp4.635630404
133b.b22x5 sst2_on_gp4.757920607
134b.l22x5 sst2_on_gp7.36250409
135b.b23x6 sst2_on_gp6.157140707
136b.l23x1 sst2_on_gp6.189370406
137b.b24x4 sst2_on_gp6.98250406
138b.b24x6 sst2_on_gp7.7550408
139b.b24x7 sst2_on_gp6.515620409
140b.l24x2 sst2_on_gp5.063120406
141b.b25x3 sst2_on_gp7.651250405
142b.l25x3 sst2_on_gp7.72850509
143b.l27x1 sst2_on_gp12.53250609
144b.l27x2 sst2_on_gp6.5820509
145b.b28x3 sst2_on_gp3.550630407
146b.b28x4 sst2_on_gp7.43750406
147b.b28x6 sst2_on_gp8.134170609
148b.b28x7 sst2_on_gp6.926250409
149g.h2x11 sst2_on_gp7.903120406
150g.ctx3 sst2_on_gp6.39050509
151g.ctx6 sst2_on_gp3.560406
152g.ctx14 sst2_on_gp4.426250409
153g.ctx15 sst2_on_gp5.05750409
154g.ctx16 sst2_on_gp4.5250708
155Lig Shared8.8070823.62418200
1561x39 Shared4.8644.948557
1571x54 Shared2.72754.7225447
1582x42 Shared5.025425.8975647
1592x50 Shared5.989586.178659
1602x53 Shared7.69510.68546
161E1x50 Shared7.359588.77833668
162E1x52 Shared7.14659.7925546
1633x36 Shared7.0158.56447
1643x37 Shared3.38356.71556
1653x50 Shared6.30756.142459
1663x51 Shared7.136884.96468
167E2.W197 Shared4.5221915.3625845
1685x35 Shared5.334379.925443
1695x36 Shared4.48558.965544
1706x48 Shared7.3904210.7283668
1716x52 Shared5.1710.122457
1727x42 Shared10.30316.11167467
1737x53 Shared4.75256.716659
1748x50 Shared2.833758.474458
1751x32 sst2_off0.97510.1275243
1761x60 sst2_off2.580837.985346
177I1x50 sst2_off2.887.565147
1782x40 sst2_off4.887.9175348
1792x64 sst2_off5.75.012254
1803x38 sst2_off11.59126.388257
1814x50 sst2_off7.838335.865349
1824x56 sst2_off3.90255.39344
1835x54 sst2_off6.5254.9025247
1846x30 sst2_off5.284176.7725346
1856x44 sst2_off6.35510.7125249
1866x51 sst2_off11.12637.376256
1877x27 sst2_off3.406673.15341
1887x45 sst2_off6.62256.3975349
1898x57 sst2_off1.8153.385245
   
Orange: nodes, hubs and links specific of sst2_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of sst2_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner sst2_on_gp Recurrence sst2_off Recurrence sst2_on_gp Hub1? sst2_off Hub1? sst2_on_gp Hub2? sst2_off Hub2? ConSurf1 ConSurf2
11x50 2x51 sst2_on_gp23.55870NoNoYesNo97
21x50 2x50 sst2_on_gp12.88876.74045NoNoYesYes99
32x50 7x46 sst2_on_gp14.9950.57971YesYesNoNo98
42x53 7x46 sst2_on_gp14.75560YesYesNoNo68
57x49 7x50 sst2_on_gp13.27120YesNoYesNo99
67x45 7x49 sst2_on_gp41.00980NoYesYesNo99
76x48 7x45 sst2_on_gp40.48978.04216YesYesNoYes89
81x54 1x58 sst2_on_gp17.10750YesYesNoNo73
98x50 I1x49 sst2_on_gp11.21920YesYesNoNo85
101x57 I1x49 sst2_on_gp14.75490NoNoNoNo75
111x57 2x44 sst2_on_gp15.93160NoNoNoNo76
121x58 2x44 sst2_on_gp16.51971.60738NoNoNoNo36
133x50 7x53 sst2_on_gp86.78690YesYesYesYes99
143x50 G.H5.25 sst2_on_gp88.18790YesYesNoNo97
15G.S1.04 G.S3.03 sst2_on_gp10.1960NoNoYesNo77
16G.S1.04 G.S4.03 sst2_on_gp10.59250NoNoNoNo77
17G.S4.03 G.S5.03 sst2_on_gp10.79050NoNoYesNo78
18G.S5.03 G.S6.02 sst2_on_gp92.65750YesNoYesNo87
19G.S6.02 G.h4s6.12 sst2_on_gp45.86770YesNoYesNo74
20G.H5.17 G.h4s6.12 sst2_on_gp45.38990NoNoYesNo54
21G.H5.17 G.H5.26 sst2_on_gp90.7360NoNoYesNo55
22G.H5.20 G.H5.26 sst2_on_gp89.34940YesNoYesNo95
23G.H5.20 G.H5.25 sst2_on_gp88.42070YesNoNoNo97
24G.H5.13 G.S6.02 sst2_on_gp46.53260NoNoYesNo87
25G.H5.13 G.H5.17 sst2_on_gp45.5770NoNoNoNo85
26G.H5.06 G.S5.03 sst2_on_gp95.43760NoNoYesNo38
27G.H5.06 G.S5.05 sst2_on_gp94.56380NoNoYesNo39
28G.S5.05 G.s6h5.01 sst2_on_gp94.77380YesNoNoNo99
29G.S5.07 G.s6h5.01 sst2_on_gp96.05730YesNoNoNo99
30G.S5.07 G.s4h3.02 sst2_on_gp95.91590YesNoNoNo99
31G.HG.04 G.s4h3.02 sst2_on_gp97.40280YesNoNoNo99
32G.HG.04 G.s4h3.01 sst2_on_gp97.50460YesNoNoNo97
33G.H4.11 G.s4h3.01 sst2_on_gp97.63710NoNoNoNo77
34G.H4.11 G.H4.15 sst2_on_gp98.510NoNoYesNo78
35G.H3.09 G.H4.15 sst2_on_gp99.15490YesNoYesNo98
36G.H3.09 G.S4.04 sst2_on_gp1000YesNoYesNo99
37G.H3.08 G.S4.04 sst2_on_gp27.29950NoNoYesNo99
38G.H2.04 G.H3.08 sst2_on_gp27.31280YesNoNoNo99
39G.H2.04 G.H2.07 sst2_on_gp27.64810YesNoYesNo99
40G.H2.07 b.l9x6 sst2_on_gp32.9270YesNoYesNo98
41b.b14x1 b.l9x6 sst2_on_gp25.5050YesNoYesNo88
42b.b10x1 b.b14x1 sst2_on_gp25.50610NoNoYesNo98
43b.b10x1 b.b11x5 sst2_on_gp25.39070NoNoYesNo96
44G.S1.07 G.S4.04 sst2_on_gp73.2880NoNoYesNo99
45G.S1.05 G.S1.07 sst2_on_gp73.25950NoNoNoNo99
46G.S1.05 G.h2s4.01 sst2_on_gp73.27350NoNoYesNo99
47G.H2.10 G.h2s4.01 sst2_on_gp77.53050NoNoYesNo79
48G.H2.09 G.H2.10 sst2_on_gp38.81240YesNoNoNo87
49G.H2.09 b.l27x1 sst2_on_gp38.42520YesNoYesNo89
50b.l25x5 b.l27x1 sst2_on_gp48.85980NoNoYesNo79
51b.l25x5 b.l27x2 sst2_on_gp48.33840NoNoYesNo79
52b.l25x3 b.l27x2 sst2_on_gp46.69290YesNoYesNo99
53b.b27x3 b.l25x3 sst2_on_gp22.53280NoNoYesNo89
54b.b27x3 b.b28x6 sst2_on_gp22.65030NoNoYesNo89
55b.b28x6 b.lhb1x11 sst2_on_gp43.57190YesNoYesNo94
56b.b28x7 b.lhb1x11 sst2_on_gp33.39080YesNoYesNo94
57b.b28x7 g.ctx16 sst2_on_gp26.45410YesNoYesNo98
58b.l4x1 g.ctx16 sst2_on_gp19.90470NoNoYesNo58
59b.b2x5 b.l4x1 sst2_on_gp19.45340YesNoNoNo75
60b.b2x5 b.b3x2 sst2_on_gp15.47890YesNoNoNo75
61b.b3x2 b.b4x6 sst2_on_gp15.04360NoNoYesNo59
62G.H2.10 b.b2x1 sst2_on_gp38.67470NoNoYesNo78
63b.b2x1 b.l27x1 sst2_on_gp42.51810YesNoYesNo89
64b.b28x4 b.l25x3 sst2_on_gp23.020YesNoYesNo69
65b.b28x4 b.b28x6 sst2_on_gp22.31550YesNoYesNo69
66b.b11x5 b.l13x7 sst2_on_gp19.67030YesNoYesNo69
67b.l13x3 b.l13x7 sst2_on_gp18.19420YesNoYesNo99
68b.b16x4 b.l13x3 sst2_on_gp17.98560YesNoYesNo69
69b.b16x4 b.b17x6 sst2_on_gp20.83050YesNoNoNo67
70b.b17x6 g.h1x14 sst2_on_gp20.65660NoNoNoNo79
71b.1x15 g.h1x14 sst2_on_gp20.30830NoNoNoNo79
72b.1x15 b.1x19 sst2_on_gp14.98580NoNoNoNo76
73b.1x19 b.b21x1 sst2_on_gp14.80470NoNoYesNo67
74b.l25x6 b.l27x1 sst2_on_gp31.99020NoNoYesNo89
75b.l23x1 b.l25x6 sst2_on_gp30.87260YesNoNoNo68
76b.l21x7 b.l23x1 sst2_on_gp30.76240NoNoYesNo56
77b.b23x6 b.l21x7 sst2_on_gp29.27960YesNoNoNo75
78b.b23x6 b.b24x6 sst2_on_gp24.61350YesNoYesNo78
79b.b21x7 b.b24x6 sst2_on_gp24.17770YesNoYesNo58
80b.b20x5 b.b21x7 sst2_on_gp11.84630YesNoYesNo75
81b.lhb1x11 g.ctx5 sst2_on_gp10.20470YesNoNoNo49
82b.b17x7 b.b21x1 sst2_on_gp10.49970YesNoYesNo87
831x50 7x50 sst2_on_gp11.25515.06983NoNoYesNo99
843x36 Lig Shared25.723543.5731YesYesYesYes70
853x36 6x48 Shared28.102411.2938YesYesYesYes78
861x54 2x51 Shared18.869522.6087YesYesYesNo77
877x49 7x53 Shared77.759894.9249YesNoYesYes99
882x50 7x49 Shared24.223894.946YesYesYesNo99
891x39 2x61 sst2_off2.8595217.0646YesYesNoNo76
903x32 7x42 sst2_off0.0029725912.8538NoNoYesYes67
913x32 Lig sst2_off0.94880568.39NoNoYesYes60
921x40 2x61 sst2_off015.6996NoNoNoNo56
932x57 7x42 sst2_off8.0936932.0843YesNoYesYes77
942x54 2x57 sst2_off026.8775NoNoYesNo67
951x47 2x54 sst2_off2.3744424.5059NoNoNoNo66
961x47 2x51 sst2_off3.5603923.5152NoNoYesNo67
972x50 3x35 sst2_off098.3294YesYesYesNo97
982x53 3x35 sst2_off4.45437100YesYesYesNo67
992x53 3x32 sst2_off1.21755.7576YesYesNoNo66
1001x60 8x53 sst2_off021.2332NoYesNoNo65
1018x53 I1x50 sst2_off027.4519NoNoNoYes57
1028x50 I1x50 sst2_off031.4677YesYesNoYes87
1037x53 8x50 sst2_off043.3465YesYesYesYes98
1041x54 2x44 sst2_off023.0777YesYesNoNo76
1053x50 6x37 sst2_off050.5982YesYesNoNo98
1063x46 6x37 sst2_off051.942NoNoNoNo98
1072x43 3x46 sst2_off070.498NoNoNoNo89
1082x43 7x53 sst2_off071.6574NoNoYesYes89
1092x41 4x42 sst2_off1.0505310.8037NoNoNoNo57
1102x42 4x42 sst2_off1.3928212.2951YesYesNoNo77
1112x42 3x46 sst2_off8.3047420.0949YesYesNoNo79
1122x44 2x45 sst2_off020.137NoNoNoNo69
1132x45 4x50 sst2_off1.27715.6469NoNoNoYes99
114E1x50 E1x52 sst2_off3.3027617.9341YesYesYesYes86
115E1x50 E2x50 sst2_off0.035450822.5982YesYesYesNo89
1163x29 E2x50 sst2_off0.039964824.9697NoNoYesNo59
1173x29 Lig sst2_off028.4163NoNoYesYes50
1181x40 2x62 sst2_off014.3452NoNoNoNo55
1192x62 E1x52 sst2_off0.33116812.4796NoNoYesYes56
120E1x49 E1x51 sst2_off1.3236815.3412NoNoNoNo44
121E1x51 E1x52 sst2_off1.6540817.2121NoNoYesYes46
1223x36 3x37 sst2_off3.3608921.1014YesYesYesYes76
1233x36 6x52 sst2_off021.5758YesYesYesYes77
1245x51 5x54 sst2_off015.9631YesNoNoYes67
1255x47 5x51 sst2_off0.066828121.2016YesNoYesNo86
1265x47 6x52 sst2_off2.2358336.664YesNoYesYes87
1273x50 6x34 sst2_off042.1449YesYesNoNo97
1283x51 5x61 sst2_off026.0501YesYesNoNo89
1293x54 5x61 sst2_off0.30485527.473NoNoNoNo89
1303x54 6x30 sst2_off028.996NoNoNoYes86
1316x30 6x34 sst2_off040.7378NoYesNoNo67
132E2x52 Lig sst2_off5.4873918.1924YesNoYesYes50
133E2.W197 E2x52 sst2_off4.2326315.1673YesYesYesNo55
1345x36 Lig sst2_off7.1173613.6812YesYesYesYes40
1355x44 6x52 sst2_off0.30573610.6825NoNoYesYes57
1365x47 6x49 sst2_off1.8699813.3281YesNoYesNo85
1376x51 6x52 sst2_off015.4677NoYesYesYes67
1386x48 7x41 sst2_off0.31311226.8722YesYesNoNo87
1397x41 7x42 sst2_off043.5731NoNoYesYes77
1401x53 7x53 sst2_off014.7036NoNoYesYes99
1411x53 2x47 sst2_off013.3281NoNoNoNo99
1421x54 2x47 sst2_off0.59385713.5494YesYesNoNo79
1431x39 7x42 sst2_off021.8287YesYesYesYes77
1442x53 7x42 sst2_off8.8962945.6495YesYesYesYes67
1456x51 7x41 sst2_off016.2108NoYesNoNo67
1466x48 6x52 sst2_off8.2091815.1146YesYesYesYes87

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
5x36LigShared23.2810.911210
6x54LigShared9.525.18751210
6x61Ligsst2_off4.4200010
E3.P286LigShared14.372.56751210
7x30Ligsst2_off5.4101010
7x31LigShared14.253.8051010
7x34LigShared17.1113.0151210
3x29Ligsst2_off5.6101210
E2x51LigShared8.197.3551010
E2x52LigShared7.934.4151210
3x32LigShared11.067.8651210
3x36LigShared8.1410.71251210
2x64Ligsst2_off7.9401010
7x35Ligsst2_off15.5201010
1x32Ligsst2_off16.7901010
E1.E106Ligsst2_off13.8801010
1x301x32sst2_off8.7700021
1x322x64sst2_off4.4301011
1x32E1.E106sst2_off10.5201011
1x351x39sst2_off8.2101022
1x352x64sst2_off4.4701021
1x357x35Shared6.795.431021
1x362x65Shared5.032.93750022
1x392x64Shared5.054.11021
1x397x42sst2_off4.9601021
2x533x32Shared5.975.67251221
2x537x42Shared12.3817.5351221
2x577x42Shared4.699.08250221
2x603x28sst2_off4.4700012
2x63E1x50Shared10.955.47750212
E1x50E2x50Shared18.2814.3651222
3x29E2x50Shared4.863.6451212
3x327x42Shared4.68.621211
3x363x37Shared10.543.8051212
3x366x48Shared7.677.3951212
3x366x52sst2_off7.8901212
4x61E2x52sst2_off7.3600021
E2.W197E2x52Shared15.274.99250221
5x39E2.W197Shared15.035.26250222
5x365x40sst2_off6.0401212
5x366x58sst2_off5.0901211
5x395x43Shared7.783.890221
6x486x51sst2_off5.0101021
6x486x52Shared8.682.651022
6x487x41Shared18.198.491022
6x516x52sst2_off8.2501212
6x516x55Shared14.512.68751211
6x517x37sst2_off3.9301212
6x517x41sst2_off5.1901212
6x547x33Shared9.952.491212
6x547x34Shared13.935.091211
7x31E3.P286sst2_off6.6901011
7x277x30Shared5.95.89750021
7x347x38Shared7.875.8951212
7x387x42sst2_off5.0500021
7x417x42sst2_off4.9901021
E2.S192Ligsst2_off3.7400010
1x31Ligsst2_off3.7200010
E3.P286E3.S285Shared3.564.451212
1x301x33sst2_off3.3600022
3x294x65Shared3.222.4151212
1x362x64sst2_off3.1700021
5x406x59Shared3.075.3750022
E2.N196E2x51sst2_off2.9200021
7x317x32sst2_off1.7401012
6x596x60sst2_off1.6200022
7x27E3.I284sst2_off1.5200022
5x335x36Shared1.450.7250021
6x58Ligsst2_on_gp02.90750010
5x43Ligsst2_on_gp04.0350210
6x51Ligsst2_on_gp09.5651210
7x42Ligsst2_on_gp05.9751210
2x63Ligsst2_on_gp08.38250210
1x392x57sst2_on_gp05.56751022
1x397x38sst2_on_gp02.83751022
2x533x36sst2_on_gp06.14751221
2x63E2.S192sst2_on_gp03.97250211
2x63E2x50sst2_on_gp03.050212
2x647x35sst2_on_gp07.31011
3x375x43sst2_on_gp02.59250221
4x615x39sst2_on_gp05.0250022
5x36E2.W197sst2_on_gp05.06251212
5x366x59sst2_on_gp04.731212
5x406x55sst2_on_gp05.6650021
5x436x52sst2_on_gp02.810212
6x546x57sst2_on_gp02.641212
6x606x61sst2_on_gp02.6850021
7x327x35sst2_on_gp02.5150021
3x29E2x52sst2_on_gp02.55251211
4x65E2x52sst2_on_gp02.840221
E2.N186E2.S192sst2_on_gp03.7250021
6x55Ligsst2_on_gp04.420210
2x60Ligsst2_on_gp04.7850010
1x291x31sst2_on_gp02.25250021
7x30E3.I284sst2_on_gp02.14251012
1x291x30sst2_on_gp01.84250022
6x547x30sst2_on_gp01.52251211
1x322x65sst2_on_gp01.171012
5x345x36sst2_on_gp010021
1x321x33sst2_on_gp00.781012
6x61E3.I284sst2_on_gp00.3650012

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
sst2_on_gp 7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7WIG-SST2-L-054,264-Gi1/β1/γ2
7YAE-SST2-Octreotide-Gi1/β1/γ2
7YAC-SST2-Paltusotine-Gi1/β1/γ2
sst2_off 7XNA-SST2-CYN154806
Network Difference
Value sst2_on_gp sst2_off
Imin 2.39 3.92
Number of Linked Nodes 893 270
Number of Specific Nodes 630 (70.55%) 7  (2.59%)
Number of Shared Nodes 263 (29.45%) 263  (97.41%)
Number of Links 1089 297
Number of Specific Links 939 (86.23%) 147  (49.49%)
Number of Shared Links 150 (13.77%) 150  (50.51%)
Number of Hubs 174 35
Number of Specific Hubs 154 (88.51%) 15  (42.86%)
Number of Shared Hubs 20 (11.49%) 20  (57.14%)
Average % Shared Neighbours (Jaccard) 10.65
Average % Shared Neighbours (Otsuka) 13.64
Average % Shared Neighbours (Overlap Coefficient) 16.65
Average % Shared Cliques (k3-6) 51.08
Graphlets Similarity 0.619205
Paths Difference
Value sst2_on_gp sst2_off
Number Of Nodes in MetaPath 85 58
Specific Nodes in MetaPath 73 (85.88%) 46  (79.31%)
Shared Nodes in MetaPath 263 (29.45%) 263  (29.45%)
Number Of Links MetaPath 88 63
Specific Links in MetaPath 83 (94.32%) 58  (92.06%)
Shared Links in MetaPath 150 (13.77%) 150  (13.77%)
Number of Shortest Paths 1375961 42825
Length Of Smallest Path 3 3
Average Path Length 32.6697 12.6834
Length of Longest Path 62 31
Minimum Path Strength 0.54875 1.44
Average Path Strength 5.35989 7.6636
Maximum Path Strength 26.17 20.035
Minimum Path Correlation 0.7025 0.7
Average Path Correlation 0.982489 0.92733
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 1.78571 4.7619
Average % Of Corr. Nodes 43.2498 54.8705
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 56.4953 41.5104
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download sst2_off_on_gp.zip<



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