Orange: nodes, hubs and links specific of ste2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ste2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner ste2_off Avg Int. Strength ste2_on Avg Int. Strength ste2_off Num Of Links ste2_on Num Of Links ConSurf
1R1.NT.Y17 ste2_off6.528.38333437
2R1.2x46 ste2_off4.4168.41667539
3R1.2x47 ste2_off7.197513.66435
4R1.E1x46 ste2_off6.83757.91667435
5R1.E1x51 ste2_off5.6557.315425
6R1.E1x59 ste2_off7.65512.95423
7R1.3x36 ste2_off7.317.37436
8R1.3x46 ste2_off4.11752.325429
9R1.3x50 ste2_off4.77610.645529
10R1.5x28 ste2_off9.05523.035425
11R1.I3.F241 ste2_off9.54755.845429
12R1.6x40 ste2_off7.62753.82438
13R1.6x50 ste2_off2.493.53519
14R2.NT.I29 ste2_off7.5255.36333434
15R2.2x46 ste2_off4.4169.33539
16R2.2x47 ste2_off7.197512.74435
17R2.2x56 ste2_off4.3366.18538
18R2.E1x51 ste2_off5.6557.40667435
19R2.E1x59 ste2_off7.65512.3233433
20R2.3x36 ste2_off7.315.75436
21R2.3x46 ste2_off4.11752.94429
22R2.3x50 ste2_off4.7767.21539
23R2.5x28 ste2_off9.616.695425
24R2.I3.F241 ste2_off9.54755.28429
25R2.6x40 ste2_off7.62752.85418
26R2.6x47 ste2_off3.2665.70667539
27R2.6x50 ste2_off2.493.53519
28R2.7x49 ste2_off4.62259.08439
29R2.7x55 ste2_off6.32513.25439
30R1.NT.P19 Shared5.0954.895447
31R1.NT.Y26 Shared5.876.398456
32R1.NT.I29 Shared7.5256.6025444
33R1.1x28 Shared7.37257.3925447
34R1.1x32 Shared5.12758.725447
35R1.1x45 Shared5.998.41667566
36R1.1x48 Shared5.8747.13714579
37R1.2x53 Shared4.025.54447
38R1.2x56 Shared5.0165.212558
39R1.2x60 Shared9.41510.94456
40R1.E1x50 Shared5.7954.298457
41R1.E1x56 Shared6.8548.61557
42R1.3x44 Shared5.336.27648
43R1.3x55 Shared4.13756.332459
44R1.4x61 Shared9.602511.3625447
45R1.5x42 Shared5.085.344558
46R1.6x47 Shared3.2665.64549
47R1.7x49 Shared4.62257.915449
48R1.7x55 Shared6.32510.235449
49R2.Lig Shared11.653812.199121230
50R1.Lig Shared12.472512.059220260
51R2.NT.Y17 Shared6.526.305447
52R2.NT.P19 Shared5.0955.2447
53R2.NT.Y26 Shared5.876.675446
54R2.1x28 Shared7.6957.4175447
55R2.1x32 Shared5.12756.9225447
56R2.1x45 Shared5.9910.7175546
57R2.1x48 Shared5.8745.02375589
58R2.2x53 Shared4.024.645447
59R2.2x60 Shared9.41513.13456
60R2.E1x46 Shared6.83757.258455
61R2.E1x50 Shared5.47257.532457
62R2.E1x56 Shared6.8547.844557
63R2.3x44 Shared5.335.528658
64R2.3x55 Shared4.13756.4275449
65R2.4x61 Shared9.602510.1625447
66R2.5x42 Shared5.084.92548
67R2.7x39 Shared4.00755.5925447
68R2.NT.S34 ste2_on8.9853.425246
69R2.1x41 ste2_on3.65.32344
70R2.1x44 ste2_on6.0655.16247
71R2.1x55 ste2_on5.406674.56347
72R2.I1.R74 ste2_on05.656056
73R2.2x43 ste2_on7.073336.36359
74R2.2x61 ste2_on5.77.35345
75R2.2x63 ste2_on8.6210.5075346
76R2.3x29 ste2_on10.25337.048358
77R2.3x32 ste2_on3.773335.725346
78R2.3x39 ste2_on3.776674.7375348
79R2.3x51 ste2_on4.326675.7075348
80R2.6x36 ste2_on4.986674.532359
81R2.6x43 ste2_on1.52.3125148
82R2.6x54 ste2_on5.416676.41347
83R2.7x36 ste2_on4.7256.9875245
84R2.7x38 ste2_on3.514.1325245
85R2.7x61 ste2_on2.178.1975246
86R1.NT.L11 ste2_on3.0955.4125243
87R1.1x41 ste2_on3.65.54354
88R1.1x58 ste2_on4.793.4525247
89R1.1x59 ste2_on4.5554.7425248
90R1.1x60 ste2_on6.437.5125244
91R1.1x61 ste2_on1.4858.2025247
92R1.2x43 ste2_on7.073336.37333369
93R1.2x52 ste2_on3.213.2244
94R1.3x25 ste2_on2.9455.8575246
95R1.3x29 ste2_on9.797.57348
96R1.3x32 ste2_on5.403335.085346
97R1.3x39 ste2_on3.776673.7425348
98R1.3x43 ste2_on2.963.3725248
99R1.3x51 ste2_on4.326676.8175348
100R1.5x27 ste2_on5.623335355
101R1.5x32 ste2_on2.595.395146
102R1.5x41 ste2_on3.84.705346
103R1.6x38 ste2_on1.5056.45248
104R1.6x58 ste2_on4.8957.355246
105R1.7x36 ste2_on4.7256.165245
106R1.7x38 ste2_on3.514.4425245
107R1.7x61 ste2_on2.177.42246
   
Orange: nodes, hubs and links specific of ste2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ste2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner ste2_off Recurrence ste2_on Recurrence ste2_off Hub1? ste2_on Hub1? ste2_off Hub2? ste2_on Hub2? ConSurf1 ConSurf2
1R1.1x45 R1.2x56 ste2_off71.53230.023176YesYesYesYes68
2R1.1x45 R1.2x60 ste2_off20.47880.959488YesYesYesYes66
3R1.2x60 R1.Lig ste2_off18.37430.672878YesYesYesYes60
4R2.1x45 R2.2x56 ste2_off39.40780YesYesYesNo68
5R1.1x55 R2.1x54 ste2_off50.09080NoNoNoNo75
6R1.1x54 R2.1x54 ste2_off1000NoNoNoNo55
7R1.1x54 R2.1x55 ste2_off50.09750.148327NoNoNoYes57
8R1.1x51 R1.7x47 ste2_off49.78230NoNoNoNo88
9R1.1x51 R2.1x54 ste2_off49.88891.56902NoNoNoNo85
10R1.1x54 R2.1x51 ste2_off49.93350.572448NoNoNoNo58
11R2.1x51 R2.7x47 ste2_off49.87570NoNoNoNo88
12R1.6x47 R1.7x52 ste2_off14.05150YesYesNoNo99
13R1.5x39 R1.6x47 ste2_off45.45190NoNoYesYes89
14R1.5x35 R1.5x39 ste2_off49.26690.94172NoNoNoNo68
15R1.3x44 R1.5x35 ste2_off49.64590YesYesNoNo86
16R1.3x40 R1.3x44 ste2_off53.00430NoNoYesYes68
17R1.3x36 R1.3x40 ste2_off53.25740YesNoNoNo66
18R1.5x42 R1.6x47 ste2_off25.17430YesYesYesYes89
19R1.5x46 R1.7x55 ste2_off14.09150NoNoYesYes99
20R1.5x42 R1.5x46 ste2_off14.88710YesYesNoNo89
21R1.6x40 R1.7x55 ste2_off10.32110YesNoYesYes89
22R2.3x36 R2.Lig ste2_off42.29420YesNoYesYes60
23R2.3x36 R2.3x40 ste2_off75.56770YesNoNoNo66
24R2.3x40 R2.3x44 ste2_off75.14550NoNoYesYes68
25R2.3x44 R2.5x35 ste2_off70.2660YesYesNoNo86
26R2.5x35 R2.5x39 ste2_off69.7181.34807NoNoNoNo68
27R2.5x39 R2.6x47 ste2_off64.21280NoNoYesNo89
28R2.6x47 R2.7x52 ste2_off19.79810YesNoNoNo99
29R2.7x49 R2.7x52 ste2_off12.22590YesNoNoNo99
30R2.5x42 R2.6x47 ste2_off35.48430YesYesYesNo89
31R2.5x42 R2.5x46 ste2_off20.80270YesYesNoNo89
32R2.5x46 R2.7x55 ste2_off19.66910NoNoYesNo99
33R2.6x40 R2.7x55 ste2_off14.37750YesNoYesNo89
34R2.1x45 R2.1x48 ste2_off40.6291.4655YesYesYesYes69
35R2.2x56 R2.3x36 ste2_off37.24853.9971YesNoYesNo86
36R1.2x56 R1.3x36 ste2_off50.61810.872964YesYesYesNo86
37R1.E1x46 R1.Lig Shared15.8039100YesNoYesYes50
38R1.2x56 R1.Lig Shared18.342845.6151YesYesYesYes80
39R2.E1x46 R2.Lig Shared10.401896.2486YesYesYesYes50
40R2.7x39 R2.Lig Shared54.23262.0384YesYesYesYes70
41R2.1x48 R2.7x39 Shared54.698159.9649YesYesYesYes97
42R1.1x45 R1.1x48 Shared91.011847.4012YesYesYesYes69
43R1.1x48 R1.7x43 Shared99.095584.3878YesYesNoNo98
44R1.7x43 R1.7x47 Shared99.370681.9837NoNoNoNo88
45R1.1x55 R1.7x47 Shared49.877681.3788NoNoNoNo78
46R2.1x55 R2.7x47 Shared49.981841.8034NoYesNoNo78
47R2.7x43 R2.7x47 Shared99.658342.2291NoNoNoNo88
48R2.1x48 R2.7x43 Shared99.47443.659YesYesNoNo98
49R1.E1x50 R2.NT.P19 ste2_on010.6556YesYesYesYes77
50R1.E1x50 R2.1x28 ste2_on0.9394298.1305YesYesYesYes77
51R1.NT.Y26 R2.1x28 ste2_on097.7442YesYesYesYes67
52R1.NT.I24 R1.NT.Y26 ste2_on096.8434NoNoYesYes66
53R1.1x28 R1.NT.I24 ste2_on3.1928296.7561YesYesNoNo76
54R1.1x28 R2.E1x54 ste2_on2.8360611.6707YesYesNoNo77
55R2.3x25 R2.E1x46 ste2_on097.969NoNoYesYes65
56R2.3x25 R2.E1x45 ste2_on098.149NoNoNoNo63
57R2.E1x45 R2.E1x59 ste2_on0.15144598.3275NoNoYesNo33
58R2.E1x50 R2.E1x59 ste2_on0.54959492.4624YesYesYesNo73
59R1.1x28 R2.E1x50 ste2_on0.92901588.3996YesYesYesYes77
60R2.1x48 R2.3x39 ste2_on016.2549YesYesNoYes98
61R1.1x45 R1.Lig ste2_on045.9349YesYesYesYes60
62R1.3x25 R1.E1x46 ste2_on099.9374NoYesYesNo65
63R1.3x25 R1.E1x45 ste2_on099.8934NoYesNoNo63
64R1.E1x45 R1.E1x59 ste2_on0.15491399.8803NoNoYesNo33
65R1.E1x50 R1.E1x59 ste2_on0.5602399.8702YesYesYesNo73
66R1.1x48 R1.2x56 ste2_on046.8342YesYesYesYes98
67R2.1x55 R2.7x50 ste2_on041.1058NoYesNoNo79
68R1.1x58 R1.1x61 ste2_on014.4812NoYesNoYes77
69R1.1x61 R2.7x55 ste2_on016.0849NoYesYesNo79
70R2.6x38 R2.7x55 ste2_on017.1425NoNoYesNo89
71R2.6x38 R2.I3.F241 ste2_on018.1855NoNoYesNo89
72R2.6x37 R2.I3.F241 ste2_on0.61780218.7108NoNoYesNo99
73R2.6x34 R2.6x37 ste2_on020.2775NoNoNoNo89
74R2.6x34 R2.6x36 ste2_on020.7101NoNoNoYes89
75R2.5x50 R2.6x36 ste2_on024.3742NoNoNoYes99
76R2.5x50 R2.6x43 ste2_on025.3863NoNoNoYes98
77R2.5x46 R2.6x43 ste2_on032.2974NoNoNoYes98
78R2.3x50 R2.5x46 ste2_on032.6234YesNoNoNo99
79R2.3x50 R2.7x49 ste2_on0.12716734.7494YesNoYesNo99
80R2.2x46 R2.7x49 ste2_on8.2695835.6108YesNoYesNo99
81R2.2x46 R2.7x50 ste2_on5.5787235.243YesNoNoNo99
82R1.6x42 R1.7x55 ste2_on014.631NoNoYesYes99
83R1.6x42 R1.7x52 ste2_on018.3987NoNoNoNo99
84R1.7x49 R1.7x52 ste2_on8.6765119.8943YesYesNoNo99
85R1.2x46 R1.7x49 ste2_on5.9033470.2265YesNoYesYes99
86R1.2x46 R1.7x50 ste2_on4.0575669.7777YesNoNoNo99
87R1.1x55 R1.7x50 ste2_on080.1644NoNoNoNo79
88R2.3x39 R2.3x43 ste2_on0.38312115.599NoYesNoNo88
89R2.3x44 R2.3x47 ste2_on014.9586YesYesNoNo89
90R2.3x43 R2.3x47 ste2_on015.3912NoNoNoNo89
91R2.3x44 R2.5x38 ste2_on0.60369812.3629YesYesNoNo89
92R2.3x51 R2.5x42 ste2_on7.1817210.165NoYesYesYes88
93R2.5x38 R2.5x42 ste2_on011.9272NoNoYesYes98
94R1.3x44 R1.5x38 ste2_on0.43468110.6525YesYesNoNo89
95R1.5x38 R1.5x42 ste2_on012.1682NoNoYesYes98
96R1.3x51 R1.5x42 ste2_on5.1535121.2192NoYesYesYes88
97R1.3x51 R1.4x47 ste2_on012.094NoYesNoNo87
98R1.3x55 R1.4x47 ste2_on013.5835YesYesNoNo97
99R1.3x55 R1.5x49 ste2_on034.5408YesYesNoNo99
100R1.3x54 R1.5x49 ste2_on2.6115535.2554NoNoNoNo89
101R1.3x54 R1.5x46 ste2_on035.9684NoNoNoNo89
102R1.3x50 R1.5x46 ste2_on048.5391YesNoNoNo99
103R1.3x50 R1.7x49 ste2_on0.12716749.1912YesNoYesYes99
104R1.3x51 R1.5x45 ste2_on012.1558NoYesNoNo87
105R1.3x55 R1.5x45 ste2_on015.0807YesYesNoNo97
106R1.5x50 R1.6x40 ste2_on3.0249611.622NoNoYesNo98
107R1.5x50 R1.6x43 ste2_on012.3845NoNoNoNo98
108R1.5x46 R1.6x43 ste2_on013.1455NoNoNoNo98
109R1.6x38 R1.7x55 ste2_on011.588NoYesYesYes89

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R2.E3.T274R2.Ligste2_off4.6300010
R2.5x28R2.LigShared27.4125.612210
R2.5x29R2.LigShared5.4913.42210
R2.E3.D275R2.LigShared10.0317.70010
R2.7x38R2.LigShared5.455.222210
R2.E3.P270R2.LigShared3.1615.252210
R2.5x25R2.LigShared10.865.322210
R2.E2.T199R2.Ligste2_off5.2500010
R2.E1x46R2.LigShared10.148.692210
R2.1x41R2.LigShared2.563.842210
R2.2x60R2.LigShared18.214.312210
R2.2x63R2.LigShared15.3826.322210
R2.3x29R2.LigShared5.564.172210
R2.3x32R2.LigShared6.996.992210
R2.3x33R2.LigShared13.6414.252210
R2.2x56R2.Ligste2_off4.8602010
R2.3x36R2.Ligste2_off12.1902010
R2.4x64R2.LigShared2.847.672210
R2.7x39R2.LigShared3.756.242210
R2.1x38R2.1x41ste2_off4.2500021
R2.1x41R2.2x64ste2_off3.9902212
R2.1x44R2.7x36Shared7.616.090021
R2.1x44R2.7x39ste2_off4.5200021
R2.1x45R2.1x48Shared11.764.282222
R2.1x45R2.2x56ste2_off3.3902221
R2.1x45R2.2x60Shared8.2528.882221
R2.1x45R2.7x39Shared2.596.492221
R2.1x48R2.7x39Shared5.176.472221
R2.2x56R2.2x60ste2_off3.2702011
R2.2x56R2.3x32Shared2.745.482011
R2.2x56R2.3x36Shared7.427.422011
R2.2x59R2.3x28ste2_off2.9800022
R2.2x60R2.2x63Shared7.9410.922211
R2.2x63R2.E1x47ste2_off2.5402212
R2.E1x46R2.E1x51Shared4.965.962211
R2.E1x46R2.E1x60Shared8.4616.922212
R2.E1x46R2.E2.V196ste2_off3.7902212
R2.E1x51R2.E1x55ste2_off2.902212
R2.E1x51R2.E1x60Shared9.6712.092212
R2.E1x51R2.E2.S197ste2_off5.0902212
R2.E1x60R2.E2.V196ste2_off9.2202222
R2.3x29R2.3x33Shared13.9612.792211
R2.3x29R2.4x72Shared11.2412.482212
R2.3x33R2.4x69ste2_off2.802212
R2.3x36R2.3x40ste2_off2.8702012
R2.3x36R2.4x61Shared6.764.512012
R2.3x37R2.4x61ste2_off5.0500022
R2.3x40R2.4x61Shared13.8817.662022
R2.4x64R2.5x27Shared2.542.542212
R2.5x25R2.5x28ste2_off4.7802211
R2.5x25R2.5x29ste2_off4.0402211
R2.5x28R2.5x29ste2_off3.6202211
R2.5x28R2.5x32Shared2.597.782212
R2.5x33R2.6x58Shared8.466.040021
R2.5x36R2.6x54Shared4.169.710022
R2.5x40R2.6x55ste2_off8.500021
R2.6x60R2.E3.Q272ste2_off6.6500022
R2.E3.K269R2.E3.Q272Shared12.24.070022
R2.E3.N271R2.E3.P270Shared3.266.520021
R2.7x36R2.E3.G273ste2_off1.8400212
R2.3x30R2.4x69Shared1.753.490022
R2.3x37R2.4x65Shared1.71.70021
R2.E3.K269R2.E3.P270Shared1.673.350021
R2.2x66R2.E1x47ste2_off1.6300022
R2.3x28R2.3x32Shared1.591.590021
R2.7x38R2.7x42ste2_off1.5702212
R2.6x59R2.6x60ste2_off1.500012
R2.2x66R2.3x25ste2_off1.4700022
R2.5x36R2.6x58ste2_off1.3300021
R2.1x37R2.1x41ste2_on04.330021
R2.1x37R2.E3.G273ste2_on03.710022
R2.1x38R2.E1x47ste2_on03.20022
R2.1x41R2.2x60ste2_on04.512211
R2.1x41R2.7x36ste2_on08.62211
R2.1x48R2.2x56ste2_on05.642221
R2.1x48R2.3x39ste2_on03.642222
R2.2x59R2.3x32ste2_on08.840021
R2.2x60R2.2x64ste2_on07.032212
R2.2x63R2.2x64ste2_on03.522212
R2.3x25R2.E1x46ste2_on03.450021
R2.E1x51R2.Ligste2_on04.172210
R2.3x36R2.3x39ste2_on05.322012
R2.5x25R2.E2.T199ste2_on08.672211
R2.5x29R2.6x58ste2_on05.812211
R2.5x32R2.6x54ste2_on03.890222
R2.5x32R2.7x38ste2_on03.140221
R2.6x54R2.7x38ste2_on06.490221
R2.6x58R2.Ligste2_on021.440210
R2.6x59R2.Ligste2_on06.180010
R2.6x60R2.E3.T274ste2_on04.420021
R2.E3.Q272R2.E3.T274ste2_on012.760021
R2.7x36R2.7x39ste2_on03.170211
R2.7x36R2.Ligste2_on010.090210
R2.3x29R2.3x30ste2_on02.92212
R2.3x29R2.4x68ste2_on02.92212
R2.1x48R2.7x42ste2_on02.592222
R2.6x55R2.Ligste2_on02.350010
R2.6x57R2.7x38ste2_on01.680021
R2.4x65R2.Ligste2_on01.610210
R2.2x63R2.2x66ste2_on01.272212
R2.2x66R2.E1x46ste2_on01.270021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
R1.1x38R1.1x41ste2_off4.2500021
R1.1x41R1.2x64Shared3.993.991112
R1.1x41R1.LigShared2.567.831110
R1.1x44R1.7x36Shared7.614.560021
R1.1x44R1.7x39ste2_off4.5200022
R1.1x45R1.1x48Shared11.766.411112
R1.1x45R1.2x56Shared3.394.531111
R1.1x45R1.2x57ste2_off3.9601112
R1.1x45R1.2x60Shared8.2524.761111
R1.1x45R1.7x39Shared2.597.781112
R1.1x48R1.2x57Shared2.643.951122
R1.1x48R1.7x39Shared5.1714.231122
R1.2x56R1.2x60ste2_off3.2701111
R1.2x56R1.3x32Shared2.744.111111
R1.2x56R1.3x36Shared7.427.421111
R1.2x56R1.LigShared8.264.361110
R1.2x59R1.3x28ste2_off2.9800022
R1.2x60R1.2x63Shared7.948.941111
R1.2x60R1.LigShared18.210.671110
R1.2x63R1.E1x47Shared2.545.091112
R1.2x63R1.LigShared17.8922.81110
R1.E1x46R1.E1x51ste2_off4.9601112
R1.E1x46R1.E1x60Shared8.4614.511112
R1.E1x46R1.E2.V196ste2_off3.7901112
R1.E1x46R1.LigShared10.145.791110
R1.E1x51R1.E1x60Shared9.6712.091022
R1.E1x60R1.E2.V196Shared9.226.141022
R1.3x29R1.3x33Shared13.966.981111
R1.3x29R1.4x72Shared11.2416.231112
R1.3x29R1.LigShared4.175.621110
R1.3x32R1.LigShared11.888.741110
R1.3x33R1.4x69Shared2.84.211112
R1.3x33R1.LigShared16.2410.041110
R1.3x36R1.3x40ste2_off2.8701112
R1.3x36R1.4x61Shared6.766.761112
R1.3x36R1.LigShared12.197.931110
R1.3x37R1.4x61ste2_off5.0500022
R1.3x40R1.4x61Shared13.8816.41022
R1.4x61R1.5x31Shared12.7215.261022
R1.4x64R1.5x27Shared2.543.821112
R1.4x64R1.LigShared2.844.61110
R1.E2.T199R1.LigShared5.252.950010
R1.5x25R1.5x28ste2_off4.7801111
R1.5x25R1.5x29Shared2.694.041111
R1.5x25R1.LigShared10.8610.61110
R1.5x28R1.5x29ste2_off3.6201111
R1.5x28R1.5x32Shared2.597.781111
R1.5x28R1.LigShared25.2338.291110
R1.5x29R1.LigShared5.4919.051110
R1.5x33R1.6x58Shared8.466.040021
R1.5x36R1.6x54Shared4.169.710022
R1.6x60R1.E3.Q272ste2_off6.6500022
R1.E3.K269R1.E3.Q272Shared12.22.710022
R1.E3.N271R1.E3.P270Shared3.264.890021
R1.E3.P270R1.LigShared3.1610.681110
R1.E3.T274R1.Ligste2_off4.6300010
R1.E3.D275R1.LigShared8.6719.90010
R1.7x38R1.LigShared5.456.461110
R1.5x26R1.5x27ste2_off2.3900012
R1.7x36R1.E3.G273ste2_off1.8400112
R1.3x37R1.4x65Shared1.71.70021
R1.E3.K269R1.E3.P270Shared1.673.350021
R1.3x28R1.3x32Shared1.591.590021
R1.7x38R1.7x42ste2_off1.5701112
R1.6x59R1.6x60ste2_off1.500012
R1.5x36R1.6x58ste2_off1.3300021
R1.1x41R1.2x60ste2_on05.641111
R1.1x41R1.7x36ste2_on08.61111
R1.1x45R1.7x36ste2_on03.931111
R1.1x45R1.Ligste2_on03.091110
R1.1x48R1.2x56ste2_on05.641121
R1.2x59R1.3x32ste2_on05.90021
R1.2x60R1.2x64ste2_on04.691112
R1.3x25R1.E1x46ste2_on03.450021
R1.4x64R1.5x31ste2_on04.891112
R1.5x26R1.Ligste2_on010.440010
R1.5x29R1.6x58ste2_on03.491111
R1.5x32R1.6x58ste2_on06.240111
R1.5x32R1.7x38ste2_on03.140111
R1.5x32R1.Ligste2_on04.420110
R1.6x54R1.7x38ste2_on06.490021
R1.6x58R1.Ligste2_on013.650110
R1.6x60R1.E3.T274ste2_on07.370021
R1.7x36R1.Ligste2_on07.570110
R1.E3.Q272R1.E3.T274ste2_on02.830021
R1.6x59R1.Ligste2_on02.470010
R1.6x57R1.7x38ste2_on01.680021
R1.1x41R1.E3.G273ste2_on01.641112
R1.4x65R1.Ligste2_on01.610110
R1.3x29R1.4x68ste2_on01.451112

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
ste2_off 7QA8-STE2-Peptide
ste2_on 7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
Network Difference
Value ste2_off ste2_on
Imin 2.51 3.07
Number of Linked Nodes 558 565
Number of Specific Nodes 32 (5.73%) 39  (6.90%)
Number of Shared Nodes 526 (94.27%) 526  (93.10%)
Number of Links 619 635
Number of Specific Links 288 (46.53%) 304  (47.87%)
Number of Shared Links 331 (53.47%) 331  (52.13%)
Number of Hubs 67 78
Number of Specific Hubs 29 (43.28%) 40  (51.28%)
Number of Shared Hubs 38 (56.72%) 38  (48.72%)
Average % Shared Neighbours (Jaccard) 36.99
Average % Shared Neighbours (Otsuka) 45.85
Average % Shared Neighbours (Overlap Coefficient) 54.82
Average % Shared Cliques (k3-6) 53.78
Graphlets Similarity 0.675126
Paths Difference
Value ste2_off ste2_on
Number Of Nodes in MetaPath 45 72
Specific Nodes in MetaPath 19 (42.22%) 46  (63.89%)
Shared Nodes in MetaPath 526 (94.27%) 526  (94.27%)
Number Of Links MetaPath 48 73
Specific Links in MetaPath 36 (75.00%) 61  (83.56%)
Shared Links in MetaPath 331 (53.47%) 331  (53.47%)
Number of Shortest Paths 558688 240008
Length Of Smallest Path 3 3
Average Path Length 24.917 23.9353
Length of Longest Path 46 64
Minimum Path Strength 1.36 1.23
Average Path Strength 5.28584 6.8666
Maximum Path Strength 22.805 30.545
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.958858 0.947747
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 4.16667 2.04082
Average % Of Corr. Nodes 35.8469 37.2839
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 41.1908 41.9876
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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