psnGPCR

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Orange: nodes, hubs and links specific of succinate_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of succinate_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	succinate_off Int. Strength	succinate_on Int. Strength	succinate_off Hub1?	succinate_on Hub1?	succinate_off Hub2?	succinate_on Hub2?	ConSurf1	ConSurf2
1	1x31	Lig	succinate_off	100	0	No	No	Yes	Yes	2	0
2	E1x50	Lig	succinate_off	100	0	Yes	Yes	Yes	Yes	8	0
3	E2x50	Lig	succinate_off	100	0	Yes	No	Yes	Yes	9	0
4	1x23	7x25	succinate_off	100	0	Yes	Yes	No	No	3	4
5	1x26	1x30	succinate_off	100	0	No	No	No	No	5	4
6	1x26	7x32	succinate_off	100	0	No	No	No	No	5	1
7	1x27	7x31	succinate_off	100	0	No	Yes	No	No	3	4
8	1x38	1x42	succinate_off	100	0	No	Yes	No	No	4	7
9	1x46	2x54	succinate_off	100	0	No	No	No	No	8	5
10	1x50	2x47	succinate_off	100	0	Yes	No	No	No	9	8
11	1x53	7x53	succinate_off	100	0	No	No	Yes	Yes	9	9
12	1x54	2x44	succinate_off	100	0	No	No	Yes	No	7	6
13	1x57	1x61	succinate_off	100	0	Yes	Yes	No	No	7	6
14	1x57	I1	succinate_off	100	0	Yes	Yes	No	No	7	6
15	1x57	2x40	succinate_off	100	0	Yes	Yes	No	No	7	8
16	1x57	7x53	succinate_off	100	0	Yes	Yes	Yes	Yes	7	9
17	1x57	8x50	succinate_off	100	0	Yes	Yes	Yes	No	7	8
18	1x60	8x57	succinate_off	100	0	No	No	No	No	5	5
19	1x61	8x50	succinate_off	100	0	No	No	Yes	No	6	8
20	2x40	I1	succinate_off	100	0	No	No	No	No	8	6
21	2x37	2x39	succinate_off	100	0	No	No	No	No	7	7
22	2x39	3x50	succinate_off	100	0	No	No	No	No	7	9
23	2x42	3x46	succinate_off	100	0	Yes	Yes	No	No	8	9
24	2x43	7x53	succinate_off	100	0	No	No	Yes	Yes	8	9
25	2x45	4x50	succinate_off	100	0	No	No	No	Yes	9	9
26	2x47	7x53	succinate_off	100	0	No	No	Yes	Yes	8	9
27	2x49	3x35	succinate_off	100	0	No	No	No	No	8	8
28	2x53	2x54	succinate_off	100	0	Yes	Yes	No	No	7	5
29	2x53	2x57	succinate_off	100	0	Yes	Yes	No	No	7	7
30	2x53	3x35	succinate_off	100	0	Yes	Yes	No	No	7	8
31	2x59	3x24	succinate_off	100	0	No	No	No	No	7	6
32	2x64	7x38	succinate_off	100	0	Yes	No	Yes	Yes	4	5
33	E1x50	E1x52	succinate_off	100	0	Yes	Yes	Yes	Yes	8	7
34	3x28	E1x50	succinate_off	100	0	No	No	Yes	Yes	5	8
35	3x22	E2	succinate_off	100	0	No	No	Yes	Yes	3	3
36	3x25	E2x50	succinate_off	100	0	No	No	Yes	No	9	9
37	3x29	E2x50	succinate_off	100	0	Yes	No	Yes	No	6	9
38	3x29	E2x52	succinate_off	100	0	Yes	No	No	No	6	5
39	3x30	3x34	succinate_off	100	0	No	Yes	No	No	5	5
40	3x32	7x42	succinate_off	100	0	No	Yes	Yes	Yes	7	7
41	3x33	4x57	succinate_off	100	0	No	No	No	Yes	5	6
42	3x33	4x61	succinate_off	100	0	No	No	No	Yes	5	3
43	3x35	7x46	succinate_off	100	0	No	No	No	No	8	8
44	3x36	6x48	succinate_off	100	0	Yes	No	Yes	Yes	7	8
45	3x36	6x51	succinate_off	100	0	Yes	No	Yes	Yes	7	6
46	3x36	7x42	succinate_off	100	0	Yes	No	Yes	Yes	7	7
47	3x38	3x42	succinate_off	100	0	Yes	No	Yes	Yes	7	7
48	3x39	7x45	succinate_off	100	0	No	No	Yes	No	9	9
49	3x40	5x50	succinate_off	100	0	No	No	No	No	8	9
50	3x43	6x40	succinate_off	100	0	No	No	No	No	8	8
51	3x43	6x44	succinate_off	100	0	No	No	Yes	Yes	8	9
52	3x43	7x52	succinate_off	100	0	No	No	Yes	Yes	8	7
53	3x46	6x36	succinate_off	100	0	No	No	No	No	9	8
54	3x47	6x37	succinate_off	100	0	No	No	No	No	9	7
55	3x49	I2x52	succinate_off	100	0	No	No	Yes	Yes	8	4
56	3x50	7x56	succinate_off	100	0	No	No	No	No	9	7
57	3x54	5x65	succinate_off	100	0	Yes	No	No	No	8	8
58	3x55	5x64	succinate_off	100	0	No	No	No	No	8	4
59	4x41	I2x56	succinate_off	100	0	Yes	No	No	No	3	2
60	4x52	4x56	succinate_off	100	0	No	No	No	No	5	5
61	4x64	4x68	succinate_off	100	0	No	No	No	No	4	2
62	4x68	E2x51	succinate_off	100	0	No	No	No	No	2	4
63	E2	E2	succinate_off	100	0	Yes	Yes	Yes	Yes	3	3
64	7x34	E2x52	succinate_off	100	0	Yes	Yes	No	No	5	5
65	5x39	E2	succinate_off	100	0	No	Yes	Yes	Yes	6	3
66	6x59	E2	succinate_off	100	0	No	No	Yes	Yes	5	3
67	5x34	5x35	succinate_off	100	0	No	No	No	Yes	1	3
68	5x37	5x41	succinate_off	100	0	No	No	No	No	3	4
69	5x43	6x55	succinate_off	100	0	Yes	No	Yes	Yes	5	6
70	5x45	5x49	succinate_off	100	0	No	No	No	No	4	6
71	5x51	6x41	succinate_off	100	0	No	No	No	No	6	8
72	5x51	6x45	succinate_off	100	0	No	No	No	No	6	6
73	5x58	5x62	succinate_off	100	0	No	Yes	No	No	8	6
74	5x58	6x34	succinate_off	100	0	No	Yes	No	Yes	8	6
75	5x62	5x66	succinate_off	100	0	No	No	No	No	6	5
76	6x39	6x43	succinate_off	100	0	No	No	No	No	6	6
77	6x44	7x45	succinate_off	100	0	Yes	Yes	Yes	No	9	9
78	6x48	6x52	succinate_off	100	0	Yes	Yes	Yes	Yes	8	8
79	6x57	7x30	succinate_off	100	0	No	No	No	No	5	5
80	6x62	7x27	succinate_off	100	0	No	No	No	No	3	3
81	7x35	7x38	succinate_off	100	0	No	No	Yes	Yes	4	5
82	7x53	8x50	succinate_off	100	0	Yes	Yes	Yes	No	9	8
83	8x49	8x52	succinate_off	100	0	No	No	No	No	6	5
84	8x50	8x54	succinate_off	100	0	Yes	No	No	No	8	7
85	8x51	8x55	succinate_off	100	0	No	No	No	No	8	1
86	2x66	E1x49	succinate_off	0	0	No	No	No	No	4	4
87	7x56	8x48	succinate_off	0	0	No	No	No	No	7	4
88	1x61	8x53	succinate_off	0	0	No	No	No	No	6	4
89	1x51	1x55	succinate_off	50	0	No	No	No	No	3	4
90	1x30	7x35	succinate_off	0	0	No	No	No	No	4	4
91	7x54	8x51	succinate_off	0	0	No	Yes	No	No	7	8
92	1x58	2x44	succinate_off	50	0	No	No	Yes	No	4	6
93	5x61	6x34	succinate_off	0	0	Yes	No	No	Yes	8	6
94	6x36	7x55	succinate_off	0	0	No	No	No	No	8	7
95	6x47	7x43	succinate_off	0	0	No	No	No	No	9	5
96	5x65	6x31	succinate_off	0	0	No	No	No	No	8	5
97	1x42	7x43	succinate_off	50	0	No	No	No	No	7	5
98	5x58	6x38	succinate_off	0	0	No	Yes	No	No	8	4
99	7x51	7x52	succinate_off	0	0	No	No	Yes	Yes	6	7
100	5x47	5x51	succinate_off	0	0	Yes	Yes	No	No	8	6
101	6x49	6x50	succinate_off	0	0	No	No	No	No	6	9
102	1x24	1x28	succinate_off	0	0	No	No	No	No	5	4
103	5x55	6x41	succinate_off	0	0	No	No	No	No	5	8
104	3x54	6x33	succinate_off	0	0	Yes	No	No	No	8	8
105	5x61	6x33	succinate_off	0	0	Yes	No	No	No	8	8
106	5x33	6x63	succinate_off	0	0	No	No	No	No	1	2
107	6x50	7x40	succinate_off	0	0	No	No	No	No	9	8
108	1x55	1x59	succinate_off	0	0	No	No	No	No	4	4
109	5x67	5x68	succinate_off	50	0	No	No	No	No	5	5
110	5x61	6x37	succinate_off	0	0	Yes	No	No	No	8	7
111	1x56	8x50	succinate_off	0	0	No	No	Yes	No	7	8
112	3x24	3x27	succinate_off	0	0	No	No	No	No	6	5
113	4x57	4x62	succinate_off	0	0	No	Yes	No	No	6	4
114	1x52	8x54	succinate_off	0	0	No	No	No	No	5	7
115	3x26	E2	succinate_off	0	0	No	No	Yes	Yes	7	3
116	3x22	3x23	succinate_off	0	0	No	No	No	No	3	3
117	4x39	4x43	succinate_off	0	0	No	No	No	No	3	3
118	5x34	5x38	succinate_off	0	0	No	No	No	No	1	3
119	6x32	6x35	succinate_off	0	0	No	No	No	No	7	6
120	4x41	4x44	succinate_off	0	0	Yes	No	No	No	3	3
121	8x51	8x52	succinate_off	0	0	No	No	No	No	8	5
122	1x23	7x28	succinate_off	0	0	Yes	Yes	No	No	3	4
123	3x21	E2	succinate_off	0	0	No	No	Yes	Yes	8	3
124	4x39	4x40	succinate_off	0	0	No	No	No	No	3	4
125	4x64	4x67	succinate_off	0	0	No	No	No	No	4	5
126	1x20	E3	succinate_off	0	0	No	No	No	No	5	7
127	1x56	1x60	succinate_off	0	0	No	No	No	No	7	5
128	1x36	2x65	succinate_off	0	0	No	No	No	No	5	4
129	2x52	3x31	succinate_off	0	0	No	No	No	No	6	6
130	4x59	4x60	succinate_off	0	0	No	No	No	No	4	8
131	1x47	2x55	succinate_off	0	0	No	No	No	No	6	5
132	1x41	1x45	succinate_off	0	0	No	No	No	No	5	5
133	3x26	4x66	succinate_off	0	0	No	No	No	No	7	4
134	4x47	4x51	succinate_off	0	0	No	No	No	No	4	4
135	3x56	I2x50	succinate_off	0	0	Yes	Yes	No	No	6	8
136	4x55	4x59	succinate_off	0	0	No	No	No	No	4	4
137	1x43	1x44	succinate_off	0	0	No	No	No	No	7	5
138	6x32	8x47	succinate_off	0	0	No	No	No	No	7	8
139	8x55	8x58	succinate_off	0	0	No	No	No	No	1	5
140	2x67	Lig	succinate_off	0	0	No	No	Yes	Yes	4	0
141	1x39	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
142	2x60	Lig	Shared	100	100	No	No	Yes	Yes	6	0
143	2x64	Lig	Shared	100	100	Yes	No	Yes	Yes	4	0
144	3x29	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
145	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
146	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
147	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
148	1x20	7x25	Shared	100	50	No	No	No	No	5	4
149	1x22	1x23	Shared	100	100	No	No	Yes	Yes	8	3
150	1x23	7x29	Shared	100	100	Yes	Yes	No	No	3	4
151	1x24	7x28	Shared	100	0	No	No	No	No	5	4
152	1x27	7x28	Shared	100	100	No	Yes	No	No	3	4
153	1x31	2x64	Shared	100	100	No	No	Yes	No	2	4
154	1x32	1x33	Shared	100	100	No	No	No	No	4	5
155	1x34	1x38	Shared	100	100	No	Yes	No	Yes	5	4
156	1x34	7x36	Shared	100	100	No	Yes	No	No	5	5
157	1x34	7x39	Shared	100	100	No	Yes	No	No	5	5
158	1x35	1x39	Shared	100	100	No	No	Yes	Yes	6	8
159	1x35	2x64	Shared	100	100	No	No	Yes	No	6	4
160	1x38	7x39	Shared	100	100	No	Yes	No	No	4	5
161	1x39	2x57	Shared	100	100	Yes	Yes	No	No	8	7
162	1x39	7x39	Shared	100	100	Yes	Yes	No	No	8	5
163	1x43	1x47	Shared	100	100	No	No	No	No	7	6
164	1x43	2x58	Shared	100	100	No	No	No	No	7	9
165	1x47	2x54	Shared	100	50	No	No	No	No	6	5
166	1x50	2x50	Shared	100	100	Yes	No	No	Yes	9	9
167	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
168	1x51	2x51	Shared	100	0	No	No	No	No	3	7
169	1x57	2x44	Shared	100	100	Yes	Yes	Yes	No	7	6
170	2x44	I1	Shared	100	100	Yes	No	No	No	6	6
171	2x37	2x40	Shared	100	100	No	No	No	No	7	8
172	2x37	I2x52	Shared	100	100	No	No	Yes	Yes	7	4
173	2x38	3x49	Shared	100	100	No	No	No	No	6	8
174	2x39	3x49	Shared	100	100	No	No	No	No	7	8
175	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	7
176	2x42	4x42	Shared	100	50	Yes	Yes	No	No	8	7
177	2x42	4x45	Shared	100	100	Yes	Yes	No	Yes	8	6
178	2x44	2x48	Shared	100	100	Yes	No	No	No	6	6
179	2x45	3x42	Shared	100	100	No	No	Yes	Yes	9	7
180	2x45	4x46	Shared	100	100	No	No	No	No	9	8
181	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
182	2x49	3x38	Shared	100	100	No	No	Yes	No	8	7
183	2x50	7x46	Shared	100	100	No	Yes	No	No	9	8
184	2x50	7x49	Shared	100	100	No	Yes	No	Yes	9	9
185	2x53	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
186	2x53	7x46	Shared	100	100	Yes	Yes	No	No	7	8
187	2x56	3x28	Shared	100	100	No	No	No	No	6	5
188	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	7	7
189	2x59	3x28	Shared	100	100	No	No	No	No	7	5
190	2x62	2x66	Shared	100	100	No	No	No	No	4	4
191	2x62	E1x52	Shared	100	100	No	No	Yes	Yes	4	7
192	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
193	E1x50	E2x50	Shared	100	100	Yes	Yes	Yes	No	8	9
194	3x24	E1x52	Shared	100	100	No	No	Yes	Yes	6	7
195	3x30	4x54	Shared	100	100	No	Yes	No	No	5	4
196	3x33	E2	Shared	100	100	No	No	Yes	Yes	5	3
197	3x36	3x37	Shared	100	100	Yes	No	Yes	Yes	7	7
198	3x37	5x43	Shared	100	100	Yes	Yes	Yes	No	7	5
199	3x37	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	8
200	3x37	6x55	Shared	100	100	Yes	Yes	Yes	Yes	7	6
201	3x38	4x50	Shared	100	100	Yes	No	No	Yes	7	9
202	3x38	4x53	Shared	100	100	Yes	No	No	No	7	7
203	3x40	6x44	Shared	100	100	No	No	Yes	Yes	8	9
204	3x40	6x48	Shared	100	100	No	No	Yes	Yes	8	8
205	3x41	4x49	Shared	100	100	No	No	No	No	5	7
206	3x42	4x46	Shared	100	100	Yes	Yes	No	No	7	8
207	3x42	4x49	Shared	100	100	Yes	Yes	No	No	7	7
208	3x42	4x50	Shared	100	100	Yes	Yes	No	Yes	7	9
209	3x44	5x54	Shared	100	0	No	No	No	Yes	7	8
210	3x45	4x45	Shared	100	100	No	No	No	Yes	7	6
211	3x47	5x54	Shared	100	100	No	No	No	Yes	9	8
212	3x48	5x57	Shared	100	100	No	No	No	No	7	8
213	3x51	3x55	Shared	100	50	Yes	Yes	No	No	8	8
214	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	8
215	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	4
216	3x51	5x61	Shared	100	50	Yes	Yes	Yes	No	8	8
217	3x52	I2x57	Shared	100	100	No	No	Yes	Yes	5	6
218	3x53	I2x52	Shared	100	100	No	No	Yes	Yes	7	4
219	3x54	5x61	Shared	100	0	Yes	No	Yes	No	8	8
220	3x54	5x64	Shared	100	100	Yes	No	No	No	8	4
221	3x55	3x56	Shared	100	100	No	No	Yes	Yes	8	6
222	3x56	I2x54	Shared	100	100	Yes	Yes	No	No	6	5
223	3x56	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	6	6
224	I2x51	I2x53	Shared	100	100	No	No	No	No	5	6
225	I2x52	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	4	6
226	I2x54	I2x57	Shared	100	100	No	No	Yes	Yes	5	6
227	4x41	4x45	Shared	100	0	Yes	No	No	Yes	3	6
228	4x56	5x43	Shared	100	0	No	No	Yes	No	5	5
229	4x56	5x46	Shared	100	0	No	No	No	No	5	4
230	4x60	5x39	Shared	100	100	No	No	No	Yes	8	6
231	4x61	E2	Shared	100	100	No	Yes	Yes	Yes	3	3
232	4x64	E2	Shared	100	100	No	No	Yes	Yes	4	3
233	4x68	E2	Shared	100	0	No	No	Yes	Yes	2	3
234	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
235	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	5
236	6x55	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
237	6x58	E2	Shared	100	100	No	Yes	Yes	Yes	4	3
238	7x34	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	3
239	5x32	5x33	Shared	100	100	No	No	No	No	2	1
240	5x32	5x35	Shared	100	0	No	No	No	Yes	2	3
241	5x33	6x62	Shared	100	100	No	No	No	No	1	3
242	5x36	6x59	Shared	100	100	No	No	No	No	4	5
243	5x39	5x43	Shared	100	100	No	Yes	Yes	No	6	5
244	5x40	6x55	Shared	100	100	No	No	Yes	Yes	5	6
245	5x40	6x56	Shared	100	100	No	No	No	No	5	5
246	5x41	6x56	Shared	100	100	No	No	No	No	4	5
247	5x44	6x52	Shared	100	100	No	No	Yes	Yes	5	8
248	5x44	6x56	Shared	100	100	No	No	No	No	5	5
249	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	8	8
250	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	8
251	5x56	5x57	Shared	100	100	No	No	No	No	5	8
252	5x56	5x60	Shared	100	100	No	No	No	No	5	4
253	5x59	5x63	Shared	100	100	No	No	No	No	3	3
254	5x64	5x68	Shared	100	100	No	No	No	No	4	5
255	6x36	7x52	Shared	100	0	No	No	Yes	Yes	8	7
256	6x39	7x52	Shared	100	100	No	No	Yes	Yes	6	7
257	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
258	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	8	9
259	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	6	8
260	6x51	6x55	Shared	100	100	Yes	Yes	Yes	Yes	6	6
261	6x51	7x37	Shared	100	0	Yes	Yes	No	No	6	7
262	6x52	6x55	Shared	100	100	Yes	Yes	Yes	Yes	8	6
263	6x54	6x57	Shared	100	50	No	No	No	No	5	5
264	6x54	7x37	Shared	100	100	No	No	No	No	5	7
265	6x55	7x34	Shared	100	100	Yes	Yes	Yes	Yes	6	5
266	6x58	7x31	Shared	100	100	No	Yes	No	No	4	4
267	6x58	7x34	Shared	100	100	No	Yes	Yes	Yes	4	5
268	6x61	7x30	Shared	100	50	No	No	No	No	3	5
269	7x34	7x38	Shared	100	100	Yes	Yes	Yes	Yes	5	5
270	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
271	7x54	8x50	Shared	100	100	No	Yes	Yes	No	7	8
272	3x29	4x65	Shared	50	100	Yes	No	No	No	6	4
273	3x37	5x461	Shared	0	0	Yes	Yes	No	No	7	5
274	6x61	7x27	Shared	0	50	No	No	No	No	3	3
275	2x41	4x42	Shared	50	100	No	No	No	No	6	7
276	6x54	7x33	Shared	0	100	No	No	No	No	5	5
277	1x50	2x51	Shared	0	100	Yes	No	No	No	9	7
278	3x30	4x62	Shared	50	50	No	Yes	No	No	5	4
279	6x51	7x41	Shared	0	100	Yes	Yes	No	No	6	8
280	5x47	6x49	Shared	0	100	Yes	Yes	No	No	8	6
281	E1x49	E1x51	Shared	0	0	No	No	No	No	4	3
282	5x47	5x48	Shared	0	100	Yes	Yes	No	No	8	4
283	5x59	5x60	Shared	0	0	No	No	No	No	3	4
284	6x50	7x37	Shared	0	0	No	No	No	No	9	7
285	5x49	5x50	Shared	0	0	No	No	No	No	6	9
286	2x56	3x31	Shared	0	0	No	No	No	No	6	6
287	3x44	5x53	Shared	0	0	No	No	No	No	7	6
288	4x41	I2x55	Shared	0	100	Yes	No	No	No	3	3
289	1x36	2x61	Shared	0	0	No	No	No	No	5	7
290	2x41	4x43	Shared	0	100	No	No	No	No	6	3
291	6x49	6x53	Shared	0	0	No	No	No	No	6	6
292	1x29	1x33	Shared	0	0	No	No	No	No	4	5
293	7x43	7x48	Shared	0	100	No	No	No	No	5	5
294	4x38	4x40	Shared	0	0	No	No	No	No	7	4
295	1x45	7x47	Shared	0	0	No	No	No	No	5	8
296	1x39	2x61	Shared	0	50	Yes	Yes	No	No	8	7
297	1x42	7x47	Shared	0	100	No	No	No	No	7	8
298	1x40	2x61	Shared	0	0	No	No	No	No	5	7
299	6x32	6x33	Shared	0	0	No	No	No	No	7	8
300	5x38	5x42	Shared	0	0	No	No	No	No	3	3
301	6x38	6x42	Shared	0	0	No	No	No	No	4	5
302	6x42	6x46	Shared	0	0	No	No	No	No	5	6
303	7x26	7x30	Shared	0	0	No	No	No	No	1	5
304	4x51	4x55	Shared	0	0	No	No	No	No	4	4
305	I2x50	I2x51	Shared	0	50	No	No	No	No	8	5
306	1x44	1x48	Shared	0	0	No	No	No	No	5	5
307	1x49	7x50	Shared	0	50	No	No	No	No	7	9
308	5x37	6x60	Shared	0	0	No	No	No	No	3	4
309	3x33	Lig	succinate_on	0	100	No	No	Yes	Yes	5	0
310	E2x52	Lig	succinate_on	0	100	No	No	Yes	Yes	5	0
311	1x23	NT	succinate_on	0	100	Yes	Yes	No	No	3	0
312	1x27	7x32	succinate_on	0	100	No	Yes	No	No	3	1
313	1x39	7x38	succinate_on	0	100	Yes	Yes	Yes	Yes	8	5
314	1x39	7x42	succinate_on	0	100	Yes	Yes	Yes	Yes	8	7
315	1x46	7x47	succinate_on	0	100	No	No	No	No	8	8
316	1x53	1x57	succinate_on	0	100	No	No	Yes	Yes	9	7
317	1x53	7x50	succinate_on	0	100	No	No	No	No	9	9
318	1x53	7x54	succinate_on	0	100	No	No	No	Yes	9	7
319	1x55	8x57	succinate_on	0	100	No	No	No	No	4	5
320	1x57	2x43	succinate_on	0	100	Yes	Yes	No	No	7	8
321	1x57	7x54	succinate_on	0	100	Yes	Yes	No	Yes	7	7
322	2x42	3x49	succinate_on	0	100	Yes	Yes	No	No	8	8
323	2x43	3x46	succinate_on	0	100	No	No	No	No	8	9
324	2x46	3x43	succinate_on	0	100	No	No	No	No	9	8
325	2x46	3x46	succinate_on	0	100	No	No	No	No	9	9
326	2x49	3x39	succinate_on	0	100	No	No	No	No	8	9
327	2x49	4x50	succinate_on	0	100	No	No	No	Yes	8	9
328	2x50	3x39	succinate_on	0	100	No	Yes	No	No	9	9
329	2x52	3x35	succinate_on	0	100	No	No	No	No	6	8
330	2x53	3x32	succinate_on	0	100	Yes	Yes	No	Yes	7	7
331	2x53	3x36	succinate_on	0	100	Yes	Yes	Yes	No	7	7
332	2x54	7x46	succinate_on	0	100	No	No	No	No	5	8
333	2x56	3x32	succinate_on	0	100	No	No	No	Yes	6	7
334	2x59	E1x50	succinate_on	0	100	No	No	Yes	Yes	7	8
335	3x25	E1x50	succinate_on	0	100	No	No	Yes	Yes	9	8
336	E1x51	E1x52	succinate_on	0	100	No	No	Yes	Yes	3	7
337	3x22	4x67	succinate_on	0	100	No	No	No	No	3	5
338	3x26	4x65	succinate_on	0	100	No	No	No	No	7	4
339	3x30	4x57	succinate_on	0	100	No	Yes	No	Yes	5	6
340	3x32	3x33	succinate_on	0	100	No	Yes	No	No	7	5
341	3x35	4x50	succinate_on	0	100	No	No	No	Yes	8	9
342	3x43	7x49	succinate_on	0	100	No	No	No	Yes	8	9
343	3x43	7x53	succinate_on	0	100	No	No	Yes	Yes	8	9
344	3x44	5x50	succinate_on	0	100	No	No	No	No	7	9
345	3x45	4x49	succinate_on	0	100	No	No	No	No	7	7
346	3x46	3x50	succinate_on	0	100	No	No	No	No	9	9
347	3x47	5x58	succinate_on	0	100	No	No	No	Yes	9	8
348	3x50	5x58	succinate_on	0	100	No	No	No	Yes	9	8
349	3x50	7x53	succinate_on	0	100	No	No	Yes	Yes	9	9
350	I2x54	I2x56	succinate_on	0	100	No	No	No	No	5	2
351	4x38	4x41	succinate_on	0	100	No	No	Yes	No	7	3
352	4x57	4x61	succinate_on	0	100	No	Yes	No	Yes	6	3
353	4x57	5x39	succinate_on	0	100	No	Yes	No	Yes	6	6
354	4x61	4x65	succinate_on	0	100	No	Yes	No	No	3	4
355	4x61	5x39	succinate_on	0	100	No	Yes	No	Yes	3	6
356	4x64	5x35	succinate_on	0	100	No	No	No	Yes	4	3
357	4x64	5x36	succinate_on	0	100	No	No	No	No	4	4
358	7x38	E2x52	succinate_on	0	100	Yes	Yes	No	No	5	5
359	5x32	5x34	succinate_on	0	100	No	No	No	No	2	1
360	5x37	6x59	succinate_on	0	100	No	No	No	No	3	5
361	5x44	6x55	succinate_on	0	100	No	No	Yes	Yes	5	6
362	5x47	6x44	succinate_on	0	100	Yes	Yes	Yes	Yes	8	9
363	5x51	6x44	succinate_on	0	100	No	No	Yes	Yes	6	9
364	5x54	5x58	succinate_on	0	100	No	Yes	No	Yes	8	8
365	5x54	6x44	succinate_on	0	100	No	Yes	Yes	Yes	8	9
366	5x58	6x37	succinate_on	0	100	No	Yes	No	No	8	7
367	5x58	6x41	succinate_on	0	100	No	Yes	No	No	8	8
368	5x66	6x34	succinate_on	0	100	No	No	No	Yes	5	6
369	5x68	5x71	succinate_on	0	100	No	No	No	No	5	0
370	5x69	I3	succinate_on	0	100	No	No	No	Yes	0	4
371	5x70	I3	succinate_on	0	100	No	No	No	Yes	0	4
372	6x31	I3	succinate_on	0	100	No	No	No	Yes	5	4
373	6x43	7x48	succinate_on	0	100	No	No	No	No	6	5
374	6x43	7x52	succinate_on	0	100	No	No	Yes	Yes	6	7
375	6x47	7x45	succinate_on	0	100	No	No	Yes	No	9	9
376	6x51	7x34	succinate_on	0	100	Yes	Yes	Yes	Yes	6	5
377	7x31	7x35	succinate_on	0	100	No	No	No	No	4	4
378	7x49	7x53	succinate_on	0	100	No	Yes	Yes	Yes	9	9
379	7x52	7x53	succinate_on	0	100	Yes	Yes	Yes	Yes	7	9
380	7x54	8x54	succinate_on	0	100	No	Yes	No	No	7	7
381	8x48	8x51	succinate_on	0	100	No	No	No	No	4	8
382	8x49	8x53	succinate_on	0	100	No	No	No	No	6	4
383	1x23	1x27	succinate_on	0	100	Yes	Yes	No	Yes	3	3
384	2x62	E1x51	succinate_on	0	100	No	No	No	No	4	3
385	6x32	6x36	succinate_on	0	50	No	No	No	No	7	8
386	6x36	7x56	succinate_on	0	50	No	No	No	No	8	7
387	5x34	6x63	succinate_on	0	50	No	No	No	No	1	2
388	1x42	7x42	succinate_on	0	50	No	No	Yes	Yes	7	7
389	1x54	2x47	succinate_on	0	50	No	No	No	No	7	8
390	5x58	6x40	succinate_on	0	50	No	Yes	No	No	8	8
391	1x57	2x47	succinate_on	0	50	Yes	Yes	No	No	7	8
392	6x39	6x42	succinate_on	0	50	No	No	No	No	6	5
393	1x38	1x41	succinate_on	0	50	No	Yes	No	No	4	5
394	3x25	4x67	succinate_on	0	0	No	No	No	No	9	5
395	2x41	4x39	succinate_on	0	0	No	No	No	No	6	3
396	1x49	1x52	succinate_on	0	0	No	No	No	No	7	5
397	1x30	1x34	succinate_on	0	0	No	No	No	Yes	4	5
398	3x30	4x59	succinate_on	0	50	No	Yes	No	No	5	4
399	4x63	5x35	succinate_on	0	50	No	No	No	Yes	5	3
400	5x65	6x30	succinate_on	0	50	No	No	No	No	8	0
401	3x56	I2x53	succinate_on	0	0	Yes	Yes	No	No	6	6
402	2x39	I2x52	succinate_on	0	50	No	No	Yes	Yes	7	4
403	6x30	6x33	succinate_on	0	50	No	No	No	No	0	8
404	5x51	5x55	succinate_on	0	0	No	No	No	No	6	5
405	7x54	7x55	succinate_on	0	0	No	Yes	No	No	7	7
406	1x56	7x54	succinate_on	0	0	No	No	No	Yes	7	7
407	5x45	5x48	succinate_on	0	50	No	No	No	No	4	4
408	5x69	6x30	succinate_on	0	0	No	No	No	No	0	0
409	5x63	5x67	succinate_on	0	0	No	No	No	No	3	5
410	1x27	1x30	succinate_on	0	50	No	Yes	No	No	3	4
411	6x63	6x64	succinate_on	0	0	No	No	No	No	2	0
412	4x66	4x67	succinate_on	0	0	No	No	No	No	4	5
413	6x45	6x49	succinate_on	0	0	No	No	No	No	6	6
414	3x34	4x57	succinate_on	0	0	No	No	No	Yes	5	6
415	8x49	8x50	succinate_on	0	0	No	No	Yes	No	6	8
416	1x55	1x56	succinate_on	0	0	No	No	No	No	4	7
417	6x34	6x38	succinate_on	0	0	No	Yes	No	No	6	4
418	3x21	E1x50	succinate_on	0	0	No	No	Yes	Yes	8	8
419	6x58	7x30	succinate_on	0	0	No	Yes	No	No	4	5
420	5x51	5x52	succinate_on	0	0	No	No	No	No	6	3
421	1x48	1x49	succinate_on	0	0	No	No	No	No	5	7
422	5x72	I3	succinate_on	0	0	No	No	No	Yes	0	4
423	3x23	3x27	succinate_on	0	0	No	No	No	No	3	5
424	1x20	1x24	succinate_on	0	0	No	No	No	No	5	5
425	4x51	4x54	succinate_on	0	0	No	No	No	No	4	4
426	5x62	6x34	succinate_on	0	0	No	No	No	Yes	6	6
427	2x65	2x66	succinate_on	0	0	No	No	No	No	4	4
428	1x26	1x27	succinate_on	0	0	No	No	No	Yes	5	3
429	3x23	3x24	succinate_on	0	0	No	No	No	No	3	6
430	7x51	7x55	succinate_on	0	0	No	No	No	No	6	7
431	4x43	4x47	succinate_on	0	0	No	No	No	No	3	4
432	4x44	4x45	succinate_on	0	0	No	No	No	Yes	3	6
433	6x32	8x48	succinate_on	0	0	No	No	No	No	7	4
434	6x34	6x35	succinate_on	0	0	No	Yes	No	No	6	6
435	5x35	5x38	succinate_on	0	0	No	Yes	No	No	3	3
436	1x58	I1	succinate_on	0	0	No	No	No	No	4	6
437	1x32	E1	succinate_on	0	0	No	No	No	No	4	0
438	2x51	2x55	succinate_on	0	0	No	No	No	No	7	5
439	4x48	4x52	succinate_on	0	0	No	No	No	No	3	5
440	1x21	1x22	succinate_on	0	0	No	No	No	No	4	8
441	6x47	7x40	succinate_on	0	0	No	No	No	No	9	8
442	1x37	1x38	succinate_on	0	0	No	No	No	Yes	5	4
443	1x33	1x37	succinate_on	0	0	No	No	No	No	5	5

Orange: nodes, hubs and links specific of succinate_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of succinate_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	succinate_off Avg Int. Strength	succinate_on Avg Int. Strength	succinate_off Num Of Links	succinate_on Num Of Links	ConSurf
1	1x50	succinate_off	0	50	4	3	9
2	2x44	succinate_off	100	0	5	3	6
3	2x64	succinate_off	100	50	4	3	4
4	3x29	succinate_off	50	0	4	2	6
5	3x36	succinate_off	100	0	4	2	7
6	3x38	succinate_off	50	0	4	3	7
7	3x54	succinate_off	0	0	4	2	8
8	4x41	succinate_off	0	0	4	3	3
9	E2x50	succinate_off	50	0	4	1	9
10	5x43	succinate_off	100	0	4	3	5
11	5x61	succinate_off	0	0	5	2	8
12	7x45	succinate_off	100	0	4	3	9
13	8x50	succinate_off	100	0	6	2	8
14	Lig	Shared	100	100	11	9	0
15	1x23	Shared	0	0	4	4	3
16	1x39	Shared	100	100	5	7	8
17	1x57	Shared	100	50	6	5	7
18	2x42	Shared	100	50	4	4	8
19	2x53	Shared	100	50	5	4	7
20	E1x50	Shared	100	100	5	5	8
21	E1x52	Shared	100	100	4	4	7
22	3x37	Shared	100	100	5	5	7
23	3x42	Shared	100	100	5	4	7
24	3x51	Shared	100	50	4	4	8
25	3x56	Shared	0	0	4	4	6
26	I2x52	Shared	100	50	4	4	4
27	I2x57	Shared	100	100	4	4	6
28	E2	Shared	100	100	16	9	3
29	5x47	Shared	0	50	5	5	8
30	6x44	Shared	100	100	4	5	9
31	6x48	Shared	100	100	6	4	8
32	6x51	Shared	100	100	5	5	6
33	6x52	Shared	100	100	6	5	8
34	6x55	Shared	100	100	7	7	6
35	7x34	Shared	100	100	5	5	5
36	7x38	Shared	100	50	4	4	5
37	7x42	Shared	50	50	4	4	7
38	7x52	Shared	0	0	4	4	7
39	7x53	Shared	100	50	5	4	9
40	1x27	succinate_on	0	50	2	5	3
41	1x34	succinate_on	0	0	3	4	5
42	1x38	succinate_on	0	0	3	4	4
43	2x50	succinate_on	0	100	3	4	9
44	3x30	succinate_on	0	0	3	4	5
45	3x32	succinate_on	0	100	2	4	7
46	4x45	succinate_on	0	0	3	4	6
47	4x50	succinate_on	0	50	3	4	9
48	4x57	succinate_on	0	0	2	4	6
49	4x61	succinate_on	0	100	2	4	3
50	5x35	succinate_on	0	0	2	4	3
51	5x39	succinate_on	0	100	3	4	6
52	5x54	succinate_on	0	0	2	4	8
53	5x58	succinate_on	0	100	3	6	8
54	I3	succinate_on	0	0	0	4	4
55	6x34	succinate_on	0	0	2	4	6
56	6x58	succinate_on	0	0	3	4	4
57	7x49	succinate_on	50	50	3	5	9
58	7x54	succinate_on	0	100	2	6	7

Orange: nodes, hubs and links specific of succinate_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of succinate_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	succinate_off Recurrence	succinate_on Recurrence	succinate_off Hub1?	succinate_on Hub1?	succinate_off Hub2?	succinate_on Hub2?	ConSurf1	ConSurf2
1	E1x50	Lig	succinate_off	17.7282	0	Yes	Yes	Yes	Yes	8	0
2	1x23	7x28	succinate_off	12.8629	0	Yes	Yes	No	No	3	4
3	1x27	7x28	succinate_off	19.1998	8.59596	No	Yes	No	No	3	4
4	1x27	7x31	succinate_off	20.8565	0	No	Yes	No	No	3	4
5	6x58	7x31	succinate_off	22.7624	4.99585	No	Yes	No	No	4	4
6	6x58	7x34	succinate_off	15.6092	7.2833	No	Yes	Yes	Yes	4	5
7	7x38	Lig	succinate_off	18.2147	6.13127	Yes	Yes	Yes	Yes	5	0
8	2x53	2x54	succinate_off	10.8524	0	Yes	Yes	No	No	7	5
9	1x50	2x47	succinate_off	94.0893	0	Yes	No	No	No	9	8
10	2x47	7x53	succinate_off	93.1202	0	No	No	Yes	Yes	8	9
11	1x57	7x53	succinate_off	74.2019	0	Yes	Yes	Yes	Yes	7	9
12	7x53	8x50	succinate_off	16.2686	0	Yes	Yes	Yes	No	9	8
13	1x57	2x40	succinate_off	68.7455	0	Yes	Yes	No	No	7	8
14	2x37	2x40	succinate_off	68.8138	1.75021	No	No	No	No	7	8
15	2x37	I2x52	succinate_off	61.1178	3.48934	No	No	Yes	Yes	7	4
16	3x36	7x42	succinate_off	36.1319	0	Yes	No	Yes	Yes	7	7
17	3x36	6x48	succinate_off	26.3731	0	Yes	No	Yes	Yes	7	8
18	6x44	6x48	succinate_off	19.4129	4.49183	Yes	Yes	Yes	Yes	9	8
19	3x43	6x44	succinate_off	28.0177	0	No	No	Yes	Yes	8	9
20	3x43	7x52	succinate_off	25.5368	0	No	No	Yes	Yes	8	7
21	3x46	6x36	succinate_off	18.1825	0	No	No	No	No	9	8
22	2x42	3x46	succinate_off	16.8838	0	Yes	Yes	No	No	8	9
23	2x53	3x35	succinate_off	10.9208	0	Yes	Yes	No	No	7	8
24	2x49	3x35	succinate_off	14.6723	0	No	No	No	No	8	8
25	2x49	3x38	succinate_off	13.2409	2.92994	No	No	Yes	No	8	7
26	E1x50	E1x52	succinate_off	10.5629	0	Yes	Yes	Yes	Yes	8	7
27	3x36	6x51	succinate_off	23.8641	0	Yes	No	Yes	Yes	7	6
28	6x48	6x52	succinate_off	47.6196	0	Yes	Yes	Yes	Yes	8	8
29	3x51	5x61	succinate_off	23.8721	8.66242	Yes	Yes	Yes	No	8	8
30	3x55	5x64	succinate_off	13.3092	0	No	No	No	No	8	4
31	4x60	5x39	succinate_off	15.8665	2.63639	No	No	No	Yes	8	6
32	6x54	7x37	succinate_off	30.2493	9.14982	No	No	No	No	5	7
33	6x54	6x57	succinate_off	26.2686	3.05732	No	No	No	No	5	5
34	6x57	7x30	succinate_off	24.2622	0	No	No	No	No	5	5
35	6x61	7x30	succinate_off	20.6152	5.15093	No	No	No	No	3	5
36	6x61	7x27	succinate_off	18.5887	2.57546	No	No	No	No	3	3
37	6x62	7x27	succinate_off	16.5581	0	No	No	No	No	3	3
38	5x33	6x62	succinate_off	14.5195	2.28746	No	No	No	No	1	3
39	5x32	5x33	succinate_off	10.4101	4.56937	No	No	No	No	2	1
40	5x61	6x34	succinate_off	10.4664	0	Yes	No	No	Yes	8	6
41	4x59	4x60	succinate_off	13.2167	0	No	No	No	No	4	8
42	6x44	7x45	succinate_off	10.965	0	Yes	Yes	Yes	No	9	9
43	7x34	7x38	Shared	17.5191	23.0186	Yes	Yes	Yes	Yes	5	5
44	1x39	Lig	Shared	12.0466	15.9346	Yes	Yes	Yes	Yes	8	0
45	1x39	7x39	Shared	13.1765	48.0587	Yes	Yes	No	No	8	5
46	7x42	Lig	Shared	34.4712	10.7948	Yes	Yes	Yes	Yes	7	0
47	2x53	7x42	Shared	45.2312	34.1346	Yes	Yes	Yes	Yes	7	7
48	2x53	7x46	Shared	37.2095	100	Yes	Yes	No	No	7	8
49	2x50	7x46	Shared	41.9984	99.5015	No	Yes	No	No	9	8
50	1x50	2x50	Shared	100	36.627	Yes	No	No	Yes	9	9
51	6x36	7x52	Shared	20.5871	23.9324	No	No	Yes	Yes	8	7
52	2x50	7x49	Shared	62.694	53.9407	No	Yes	No	Yes	9	9
53	6x48	7x45	Shared	53.1403	31.1105	Yes	Yes	Yes	No	8	9
54	7x45	7x49	Shared	63.1122	32.7056	Yes	No	No	Yes	9	9
55	3x36	3x37	Shared	15.4564	27.7264	Yes	No	Yes	Yes	7	7
56	6x55	7x34	Shared	12.7986	11.1659	Yes	Yes	Yes	Yes	6	5
57	6x52	6x55	Shared	32.7463	24.1817	Yes	Yes	Yes	Yes	8	6
58	6x51	6x52	Shared	10.6353	17.6849	Yes	Yes	Yes	Yes	6	8
59	I2x52	I2x57	Shared	57.4548	37.5741	Yes	Yes	Yes	Yes	4	6
60	3x56	I2x57	Shared	53.6751	31.249	Yes	Yes	Yes	Yes	6	6
61	3x55	3x56	Shared	48.8983	25.1675	No	No	Yes	Yes	8	6
62	3x51	3x55	Shared	34.5195	23.5669	Yes	Yes	No	No	8	8
63	3x37	5x43	Shared	14.9618	16.1728	Yes	Yes	Yes	No	7	5
64	6x51	7x37	Shared	32.887	15.198	Yes	Yes	No	No	6	7
65	6x55	E2	Shared	26.8758	22.3428	Yes	Yes	Yes	Yes	6	3
66	5x39	5x43	Shared	12.8589	11.4484	No	Yes	Yes	No	6	5
67	3x32	Lig	succinate_on	0.369924	13.0712	No	Yes	Yes	Yes	7	0
68	1x23	1x27	succinate_on	0	10.7893	Yes	Yes	No	Yes	3	3
69	1x27	1x30	succinate_on	0	25.4888	No	Yes	No	No	3	4
70	1x30	1x34	succinate_on	0	27.5935	No	No	No	Yes	4	5
71	1x34	7x39	succinate_on	2.39646	31.188	No	Yes	No	No	5	5
72	1x37	1x38	succinate_on	0	11.0717	No	No	No	Yes	5	4
73	1x38	7x39	succinate_on	9.61399	14.8435	No	Yes	No	No	4	5
74	1x39	7x42	succinate_on	0	23.6223	Yes	Yes	Yes	Yes	8	7
75	1x50	7x50	succinate_on	3.02774	30.7339	Yes	No	No	No	9	9
76	1x53	7x50	succinate_on	0	23.4783	No	No	No	No	9	9
77	1x53	7x54	succinate_on	0	13.686	No	No	No	Yes	9	7
78	2x43	3x46	succinate_on	0	10.9831	No	No	No	No	8	9
79	2x50	3x39	succinate_on	0	79.9446	No	Yes	No	No	9	9
80	2x49	3x39	succinate_on	0	78.787	No	No	No	No	8	9
81	2x49	4x50	succinate_on	0	74.6829	No	No	No	Yes	8	9
82	3x42	4x50	succinate_on	0.0120627	71.609	Yes	Yes	No	Yes	7	9
83	3x42	4x49	succinate_on	2.98753	67.8704	Yes	Yes	No	No	7	7
84	3x45	4x49	succinate_on	0	65.3171	No	No	No	No	7	7
85	2x42	3x45	succinate_on	1.36711	55.0263	Yes	Yes	No	No	8	7
86	2x42	3x49	succinate_on	0	47.8316	Yes	Yes	No	No	8	8
87	2x39	3x49	succinate_on	3.16043	44.9682	No	No	No	No	7	8
88	2x39	I2x52	succinate_on	0	43.506	No	No	Yes	Yes	7	4
89	2x53	3x36	succinate_on	0	28.2415	Yes	Yes	Yes	No	7	7
90	2x56	3x32	succinate_on	0	34.19	No	No	No	Yes	6	7
91	2x56	3x28	succinate_on	4.09731	31.1437	No	No	No	No	6	5
92	2x59	3x28	succinate_on	1.43546	29.604	No	No	No	No	7	5
93	2x59	E1x50	succinate_on	0	13.5973	No	No	Yes	Yes	7	8
94	2x59	E1x52	succinate_on	1.40732	15.2479	No	No	Yes	Yes	7	7
95	4x57	4x61	succinate_on	0	19.1803	No	Yes	No	Yes	6	3
96	3x30	4x57	succinate_on	0	20.7311	No	Yes	No	Yes	5	6
97	3x33	E2	succinate_on	9.07117	40.8031	No	No	Yes	Yes	5	3
98	4x61	E2	succinate_on	1.31082	23.5558	No	Yes	Yes	Yes	3	3
99	E2	E2x52	succinate_on	8.25091	13.2761	Yes	Yes	No	No	3	5
100	1x39	7x38	succinate_on	0	23.3841	Yes	Yes	Yes	Yes	8	5
101	3x30	4x54	succinate_on	1.58826	10.4126	No	Yes	No	No	5	4
102	6x51	7x34	succinate_on	0	12.5284	Yes	Yes	Yes	Yes	6	5
103	5x47	6x52	succinate_on	3.50221	49.3548	Yes	Yes	Yes	Yes	8	8
104	5x47	6x44	succinate_on	0	20.3323	Yes	Yes	Yes	Yes	8	9
105	5x47	6x48	succinate_on	7.04865	27.3553	Yes	Yes	Yes	Yes	8	8
106	7x49	7x53	succinate_on	0	47.7042	No	Yes	Yes	Yes	9	9
107	5x54	6x44	succinate_on	0	17.8621	No	Yes	Yes	Yes	8	9
108	5x54	5x58	succinate_on	0	11.8582	No	Yes	No	Yes	8	8
109	4x64	E2	succinate_on	3.16446	33.2263	No	No	Yes	Yes	4	3
110	4x64	5x35	succinate_on	0	22.4259	No	No	No	Yes	4	3
111	5x32	5x35	succinate_on	8.34339	13.5863	No	No	No	Yes	2	3
112	3x50	7x53	succinate_on	0	11.1271	No	No	Yes	Yes	9	9
113	3x50	5x58	succinate_on	0	12.7278	No	No	No	Yes	9	8
114	7x52	7x53	succinate_on	0	44.7466	Yes	Yes	Yes	Yes	7	9
115	6x39	7x52	succinate_on	2.77845	14.982	No	No	Yes	Yes	6	7
116	6x39	6x42	succinate_on	0	13.2429	No	No	No	No	6	5
117	6x32	6x36	succinate_on	0	20.3877	No	No	No	No	7	8
118	6x32	6x33	succinate_on	8.3273	14.9211	No	No	No	No	7	8
119	6x30	6x33	succinate_on	0	13.0324	No	No	No	No	0	8
120	6x58	7x30	succinate_on	0	10.2742	No	Yes	No	No	4	5
121	3x37	6x55	succinate_on	3.02372	10.0194	Yes	Yes	Yes	Yes	7	6
122	2x53	3x32	succinate_on	0	50.0582	Yes	Yes	No	Yes	7	7
123	6x58	E2	succinate_on	9.17571	10.3185	No	Yes	Yes	Yes	4	3
124	3x32	3x33	succinate_on	0	33.2041	No	Yes	No	No	7	5
125	3x37	6x52	succinate_on	7.31001	13.974	Yes	Yes	Yes	Yes	7	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x31	Lig	succinate_off	5.2	0	1	0	1	0
1x39	Lig	Shared	6.675	10.175	0	1	1	0
2x60	Lig	Shared	10.625	6.01	0	0	1	0
2x64	Lig	Shared	17.435	8.54	1	0	1	0
E1x50	Lig	succinate_off	10.165	0	1	0	1	0
3x29	Lig	Shared	27.39	7.08	1	0	1	0
3x32	Lig	Shared	11.995	5.355	1	1	1	0
E2x50	Lig	succinate_off	4.72	0	1	0	1	0
7x38	Lig	Shared	13.855	25.16	1	1	1	0
7x42	Lig	Shared	4.535	5.83	1	1	1	0
1x31	2x64	Shared	11.785	8.42	1	0	1	1
1x35	1x39	Shared	4.69	12.895	0	0	2	1
1x35	2x64	Shared	10.55	7.035	0	0	2	1
1x39	2x57	Shared	7.03	5.275	0	1	1	2
1x39	7x39	Shared	11.13	9.04	0	1	1	2
2x53	2x57	succinate_off	9.74	0	1	0	2	2
2x53	7x42	Shared	15	13.93	1	0	2	1
2x56	3x28	Shared	5.85	7.315	0	0	2	2
2x59	E1x52	Shared	16.76	9.58	1	0	2	2
2x59	3x28	Shared	9.115	15.43	1	0	2	2
2x63	E1x50	Shared	4.94	9.265	0	0	2	1
2x64	7x38	succinate_off	5.14	0	1	0	1	1
E1x50	E1x52	succinate_off	12.54	0	1	0	1	2
3x28	E1x50	succinate_off	4.52	0	0	0	2	1
E1x50	E2x50	Shared	9.14	7.185	1	0	1	1
3x25	E2x50	succinate_off	7.28	0	0	0	2	1
3x29	E2x50	succinate_off	7.66	0	1	0	1	1
3x29	E2x52	succinate_off	5.96	0	1	0	1	1
3x32	7x42	succinate_off	7.31	0	1	1	1	1
3x33	4x57	succinate_off	6.92	0	1	1	1	2
3x33	4x61	succinate_off	11.165	0	1	1	1	2
3x33	E2	Shared	8.71	10.18	1	1	1	2
3x36	7x42	succinate_off	9.135	0	0	0	2	1
4x61	E2	Shared	7.18	10.045	1	1	2	2
E2	E2	succinate_off	20.305	0	1	1	2	2
E2	E2x52	Shared	11.51	4.45	1	1	2	1
7x34	E2x52	succinate_off	8.05	0	1	1	2	1
7x34	E2	Shared	5.27	5.34	1	1	2	2
7x34	7x38	Shared	13.89	18.52	1	1	2	1
7x35	7x38	succinate_off	5.635	0	0	0	2	1
3x29	4x65	Shared	4.385	5.64	1	0	1	2
1x39	2x61	Shared	2.42	3.63	0	1	1	2
3x21	E2	succinate_off	2.11	0	0	0	2	2
2x67	Lig	succinate_off	0.42	0	0	0	1	0
3x33	Lig	succinate_on	0	7.46	1	1	1	0
E2x52	Lig	succinate_on	0	8.35	1	1	1	0
1x39	7x38	succinate_on	0	5.14	0	1	1	1
1x39	7x42	succinate_on	0	8.765	0	1	1	1
2x53	3x32	succinate_on	0	7.915	1	0	2	1
2x53	3x36	succinate_on	0	4.87	1	0	2	2
2x56	3x32	succinate_on	0	6.635	0	0	2	1
2x59	E1x50	succinate_on	0	6.4	1	0	2	1
3x25	E1x50	succinate_on	0	7.84	0	0	2	1
3x32	3x33	succinate_on	0	4.5	1	1	1	1
4x57	4x61	succinate_on	0	5.71	0	1	2	2
4x61	4x65	succinate_on	0	5.89	1	1	2	2
7x38	E2x52	succinate_on	0	5.955	1	1	1	1
1x42	7x42	succinate_on	0	4.08	0	0	2	1
3x21	E1x50	succinate_on	0	2.11	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	succinate_off	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
	succinate_on	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1

Network Difference
Value	succinate_off	succinate_on
I_min	4.46	4.26
Number of Linked Nodes	265	269
Number of Specific Nodes	10 (3.77%)	14 (5.20%)
Number of Shared Nodes	255 (96.23%)	255 (94.80%)
Number of Links	308	303
Number of Specific Links	140 (45.45%)	135 (44.55%)
Number of Shared Links	168 (54.55%)	168 (55.45%)
Number of Hubs	39	45
Number of Specific Hubs	13 (33.33%)	19 (42.22%)
Number of Shared Hubs	26 (66.67%)	26 (57.78%)
Average % Shared Neighbours (Jaccard)	40.08
Average % Shared Neighbours (Otsuka)	48.84
Average % Shared Neighbours (Overlap Coefficient)	57.22
Average % Shared Cliques (k3-6)	80.11
Graphlets Similarity	0.66341

Paths Difference
Value	succinate_off	succinate_on
Number Of Nodes in MetaPath	63	77
Specific Nodes in MetaPath	22 (34.92%)	36 (46.75%)
Shared Nodes in MetaPath	255 (96.23%)	255 (96.23%)
Number Of Links MetaPath	66	83
Specific Links in MetaPath	42 (63.64%)	59 (71.08%)
Shared Links in MetaPath	168 (54.55%)	168 (54.55%)
Number of Shortest Paths	52483	50746
Length Of Smallest Path	3	3
Average Path Length	14.1198	12.6816
Length of Longest Path	36	32
Minimum Path Strength	1.27	0.6175
Average Path Strength	8.21559	7.18724
Maximum Path Strength	22.4125	21.84
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.91028	0.922785
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	3.33333
Average % Of Corr. Nodes	42.3904	51.5669
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	46.9527	49.1463
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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