psnGPCR

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Orange: nodes, hubs and links specific of tachykinin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of tachykinin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	tachykinin_off Int. Strength	tachykinin_on Int. Strength	tachykinin_off Hub1?	tachykinin_on Hub1?	tachykinin_off Hub2?	tachykinin_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	tachykinin_off	100	0	No	No	Yes	Yes	6	0
2	E2x52	Lig	tachykinin_off	100	0	Yes	No	Yes	Yes	4	0
3	5x40	Lig	tachykinin_off	100	0	No	No	Yes	Yes	5	0
4	5x43	Lig	tachykinin_off	100	0	Yes	No	Yes	Yes	5	0
5	5x461	Lig	tachykinin_off	100	0	Yes	No	Yes	Yes	6	0
6	6x48	Lig	tachykinin_off	100	0	Yes	Yes	Yes	Yes	8	0
7	6x52	Lig	tachykinin_off	100	0	Yes	No	Yes	Yes	7	0
8	7x42	Lig	tachykinin_off	100	0	No	No	Yes	Yes	7	0
9	1x39	7x38	tachykinin_off	100	0	No	Yes	No	Yes	7	5
10	1x46	1x50	tachykinin_off	100	0	No	No	Yes	No	8	9
11	1x50	2x47	tachykinin_off	100	0	Yes	No	No	No	9	9
12	1x53	7x53	tachykinin_off	100	0	No	No	Yes	Yes	8	9
13	1x56	8x54	tachykinin_off	100	0	No	No	No	No	8	6
14	1x57	8x50	tachykinin_off	100	0	No	No	Yes	Yes	7	9
15	1x58	2x44	tachykinin_off	100	0	No	No	No	No	2	6
16	8x50	I1x50	tachykinin_off	100	0	Yes	Yes	Yes	No	9	7
17	2x37	2x40	tachykinin_off	100	0	No	No	No	Yes	7	8
18	2x38	3x49	tachykinin_off	100	0	No	No	No	No	6	9
19	2x39	3x46	tachykinin_off	100	0	No	No	No	No	8	9
20	2x41	4x39	tachykinin_off	100	0	Yes	No	No	No	5	2
21	2x53	2x57	tachykinin_off	100	0	No	Yes	Yes	Yes	7	6
22	2x57	3x27	tachykinin_off	100	0	Yes	Yes	No	No	6	4
23	2x57	3x31	tachykinin_off	100	0	Yes	Yes	No	Yes	6	4
24	2x63	E1x52	tachykinin_off	100	0	No	No	No	No	4	7
25	2x67	E1x51	tachykinin_off	100	0	No	No	No	No	5	2
26	E1x49	E2	tachykinin_off	100	0	No	No	Yes	Yes	4	3
27	3x24	E1x50	tachykinin_off	100	0	No	Yes	Yes	Yes	5	8
28	3x25	E1x50	tachykinin_off	100	0	No	No	Yes	Yes	9	8
29	3x28	E1x50	tachykinin_off	100	0	No	Yes	Yes	Yes	5	8
30	E1x50	E2	tachykinin_off	100	0	Yes	Yes	Yes	Yes	8	3
31	E1x51	E1x52	tachykinin_off	100	0	No	No	No	No	2	7
32	3x25	E2x50	tachykinin_off	100	0	No	No	No	No	9	9
33	3x28	3x29	tachykinin_off	100	0	No	Yes	Yes	Yes	5	5
34	3x29	E2x52	tachykinin_off	100	0	Yes	Yes	Yes	No	5	4
35	3x30	4x57	tachykinin_off	100	0	No	No	No	No	6	7
36	3x33	5x43	tachykinin_off	100	0	Yes	Yes	Yes	No	5	5
37	3x36	5x461	tachykinin_off	100	0	No	No	Yes	No	7	6
38	3x37	3x41	tachykinin_off	100	0	Yes	Yes	No	No	7	5
39	3x37	4x53	tachykinin_off	100	0	Yes	Yes	No	No	7	8
40	3x41	5x50	tachykinin_off	100	0	No	No	No	No	5	9
41	3x44	5x54	tachykinin_off	100	0	No	No	No	No	7	8
42	3x47	5x54	tachykinin_off	100	0	No	No	No	No	9	8
43	3x49	3x50	tachykinin_off	100	0	No	No	No	No	9	9
44	3x50	3x53	tachykinin_off	100	0	No	No	No	No	9	8
45	3x51	3x56	tachykinin_off	100	0	Yes	No	No	No	8	6
46	3x51	5x56	tachykinin_off	100	0	Yes	No	No	No	8	4
47	3x52	I2	tachykinin_off	100	0	No	No	Yes	Yes	5	6
48	3x53	I2	tachykinin_off	100	0	No	No	Yes	Yes	8	6
49	I2	I2	tachykinin_off	100	0	Yes	Yes	Yes	Yes	6	6
50	4x56	5x43	tachykinin_off	100	0	No	No	Yes	No	5	5
51	4x56	5x46	tachykinin_off	100	0	No	No	No	No	5	4
52	4x59	4x60	tachykinin_off	100	0	No	No	No	No	4	8
53	4x65	E2x52	tachykinin_off	100	0	No	Yes	Yes	No	5	4
54	E2	E2x51	tachykinin_off	100	0	Yes	Yes	No	Yes	3	4
55	5x31	E2	tachykinin_off	100	0	No	No	Yes	Yes	1	3
56	5x37	6x59	tachykinin_off	100	0	No	No	No	No	3	5
57	5x40	6x56	tachykinin_off	100	0	No	No	No	No	5	5
58	5x461	6x52	tachykinin_off	100	0	Yes	No	Yes	No	6	7
59	5x54	6x41	tachykinin_off	100	0	No	No	No	No	8	8
60	5x58	6x38	tachykinin_off	100	0	No	Yes	No	No	9	5
61	5x65	6x31	tachykinin_off	100	0	No	Yes	No	No	8	5
62	6x36	7x53	tachykinin_off	100	0	No	No	Yes	Yes	8	9
63	6x36	8x47	tachykinin_off	100	0	No	No	No	No	8	8
64	6x39	7x52	tachykinin_off	100	0	No	No	No	No	5	8
65	6x40	7x49	tachykinin_off	100	0	Yes	No	No	No	7	9
66	6x47	7x45	tachykinin_off	100	0	No	No	No	No	8	9
67	6x57	6x58	tachykinin_off	100	0	No	No	No	No	4	4
68	7x29	7x32	tachykinin_off	100	0	No	No	No	No	3	1
69	7x39	7x43	tachykinin_off	100	0	Yes	Yes	No	No	5	5
70	CT	CT	tachykinin_off	100	0	Yes	No	Yes	No	5	5
71	5x36	Lig	tachykinin_off	100	0	No	No	Yes	Yes	4	0
72	3x22	3x26	tachykinin_off	50	0	No	No	No	No	3	6
73	2x48	4x50	tachykinin_off	50	0	No	No	Yes	No	6	9
74	7x30	E3	tachykinin_off	25	0	No	No	Yes	Yes	4	3
75	2x46	3x43	tachykinin_off	25	0	No	No	No	No	9	8
76	1x35	7x39	tachykinin_off	25	0	Yes	Yes	Yes	Yes	4	5
77	2x42	3x46	tachykinin_off	50	0	Yes	Yes	No	No	7	9
78	5x61	6x34	tachykinin_off	50	0	No	No	No	No	8	6
79	8x56	CT	tachykinin_off	25	0	No	No	Yes	No	3	5
80	6x37	6x40	tachykinin_off	50	0	No	No	Yes	No	8	7
81	3x43	6x40	tachykinin_off	25	0	No	No	Yes	No	8	7
82	6x43	7x52	tachykinin_off	0	0	No	No	No	No	6	8
83	5x31	5x34	tachykinin_off	50	0	No	No	No	No	1	1
84	3x54	3x55	tachykinin_off	0	0	No	No	Yes	Yes	8	7
85	8x55	CT	tachykinin_off	25	0	No	No	Yes	No	5	5
86	3x47	5x57	tachykinin_off	25	0	No	No	No	No	9	7
87	7x33	7x37	tachykinin_off	0	0	No	No	No	No	5	6
88	2x49	4x50	tachykinin_off	0	0	No	No	Yes	No	8	9
89	5x61	5x62	tachykinin_off	25	0	No	No	No	No	8	5
90	1x51	1x54	tachykinin_off	0	0	No	No	No	No	4	7
91	3x37	4x52	tachykinin_off	0	0	Yes	Yes	No	No	7	4
92	8x57	8x58	tachykinin_off	0	0	No	No	No	No	4	6
93	5x68	6x27	tachykinin_off	25	0	No	No	No	No	5	2
94	7x55	7x56	tachykinin_off	25	0	No	No	No	No	6	7
95	6x27	6x31	tachykinin_off	25	0	No	No	No	No	2	5
96	6x28	6x32	tachykinin_off	25	0	No	No	No	No	4	8
97	5x41	6x59	tachykinin_off	25	0	No	No	No	No	5	5
98	7x54	8x51	tachykinin_off	0	0	No	No	No	No	7	8
99	1x34	1x35	tachykinin_off	25	0	No	No	Yes	Yes	4	4
100	2x65	7x34	tachykinin_off	0	0	No	No	No	Yes	5	5
101	1x44	1x45	tachykinin_off	0	0	No	No	Yes	No	4	4
102	3x23	3x24	tachykinin_off	25	0	No	No	No	Yes	3	5
103	2x67	7x31	tachykinin_off	25	0	No	No	No	No	5	4
104	1x30	1x34	tachykinin_off	0	0	No	No	No	No	1	4
105	5x38	5x42	tachykinin_off	0	0	No	No	No	No	4	4
106	1x47	2x55	tachykinin_off	0	0	No	No	No	No	6	4
107	5x41	5x45	tachykinin_off	0	0	No	No	No	No	5	4
108	1x45	7x51	tachykinin_off	0	0	Yes	No	No	No	4	7
109	6x57	6x60	tachykinin_off	0	0	No	No	No	No	4	5
110	6x35	7x56	tachykinin_off	0	0	No	No	No	No	6	7
111	5x63	5x66	tachykinin_off	0	0	No	No	No	No	3	4
112	1x37	1x40	tachykinin_off	0	0	No	No	No	No	5	4
113	4x43	4x47	tachykinin_off	0	0	No	No	No	No	2	3
114	6x25	6x28	tachykinin_off	0	0	No	No	No	No	3	4
115	4x54	4x55	tachykinin_off	0	0	No	No	No	No	4	4
116	6x29	6x32	tachykinin_off	0	0	No	No	No	No	5	8
117	1x32	1x33	tachykinin_off	0	0	No	No	No	No	3	4
118	6x33	6x37	tachykinin_off	0	0	No	No	No	No	7	8
119	6x32	8x48	tachykinin_off	0	0	No	No	No	Yes	8	4
120	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
121	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
122	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
123	6x55	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
124	1x28	1x30	Shared	100	100	No	No	No	No	2	1
125	1x28	1x31	Shared	100	100	No	No	No	Yes	2	2
126	1x30	1x31	Shared	100	100	No	No	No	Yes	1	2
127	1x32	2x66	Shared	100	100	No	No	No	No	3	5
128	1x35	7x35	Shared	100	100	Yes	Yes	No	Yes	4	3
129	1x38	7x39	Shared	100	33.3333	No	No	Yes	Yes	4	5
130	1x39	2x62	Shared	100	100	No	Yes	No	Yes	7	6
131	1x39	7x39	Shared	100	100	No	Yes	Yes	Yes	7	5
132	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	5
133	1x45	7x47	Shared	100	100	Yes	No	No	Yes	4	7
134	1x46	7x46	Shared	100	100	No	No	No	No	8	9
135	1x48	1x49	Shared	100	33.3333	No	No	No	No	4	8
136	1x49	7x50	Shared	100	100	No	No	No	No	8	9
137	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
138	1x50	2x51	Shared	100	33.3333	Yes	No	No	No	9	7
139	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
140	1x52	8x54	Shared	100	100	No	No	No	No	6	6
141	1x54	2x44	Shared	100	100	No	No	No	No	7	6
142	1x55	1x59	Shared	100	100	Yes	Yes	No	No	4	4
143	1x55	1x60	Shared	100	100	Yes	Yes	No	No	4	5
144	1x55	8x56	Shared	100	33.3333	Yes	Yes	No	No	4	3
145	1x56	8x50	Shared	100	100	No	No	Yes	Yes	8	9
146	1x56	8x53	Shared	100	33.3333	No	No	No	No	8	6
147	1x57	2x40	Shared	100	100	No	No	No	Yes	7	8
148	1x57	2x44	Shared	100	100	No	No	No	No	7	6
149	1x60	I1x50	Shared	100	66.6667	No	No	Yes	No	5	7
150	I1x48	I1x51	Shared	100	100	No	No	No	No	6	6
151	2x40	I1x50	Shared	100	100	No	Yes	Yes	No	8	7
152	8x49	I1x50	Shared	100	100	No	Yes	Yes	No	6	7
153	2x41	I1x51	Shared	100	33.3333	Yes	No	No	No	5	6
154	2x38	4x42	Shared	100	100	No	No	No	Yes	6	7
155	2x41	4x42	Shared	100	100	Yes	No	No	Yes	5	7
156	2x41	4x43	Shared	100	100	Yes	No	No	No	5	2
157	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
158	2x42	4x42	Shared	100	100	Yes	Yes	No	Yes	7	7
159	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
160	2x42	4x46	Shared	100	100	Yes	Yes	No	Yes	7	8
161	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
162	2x45	3x42	Shared	100	100	No	No	No	No	9	8
163	2x45	4x46	Shared	100	100	No	No	No	Yes	9	8
164	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
165	2x48	2x52	Shared	100	100	No	No	No	No	6	6
166	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
167	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
168	2x50	7x49	Shared	100	100	Yes	Yes	No	No	9	9
169	2x55	2x56	Shared	100	33.3333	No	No	No	Yes	4	5
170	2x57	3x32	Shared	100	100	Yes	Yes	No	No	6	6
171	2x58	7x42	Shared	100	100	No	No	No	No	7	7
172	2x60	3x24	Shared	100	100	No	No	No	Yes	5	5
173	2x61	3x28	Shared	100	100	No	Yes	No	Yes	6	5
174	2x62	2x66	Shared	100	100	No	Yes	No	No	6	5
175	2x64	E1x50	Shared	100	100	No	Yes	Yes	Yes	4	8
176	2x67	E1x49	Shared	100	100	No	No	No	No	5	4
177	E1x49	E1x51	Shared	100	100	No	No	No	No	4	2
178	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	8	7
179	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
180	3x22	E2	Shared	100	100	No	No	Yes	Yes	3	3
181	3x27	3x31	Shared	100	100	No	No	No	Yes	4	4
182	3x29	4x61	Shared	100	100	Yes	Yes	Yes	Yes	5	6
183	3x29	4x65	Shared	100	100	Yes	Yes	No	Yes	5	5
184	3x30	4x54	Shared	100	100	No	No	No	No	6	4
185	3x30	4x62	Shared	100	100	No	No	No	No	6	5
186	3x33	4x61	Shared	100	100	Yes	Yes	Yes	Yes	5	6
187	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
188	3x37	5x461	Shared	100	100	Yes	Yes	Yes	No	7	6
189	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
190	3x40	5x50	Shared	100	100	No	No	No	No	7	9
191	3x40	6x44	Shared	100	100	No	No	No	Yes	7	9
192	3x47	5x58	Shared	100	100	No	No	No	Yes	9	9
193	3x48	3x52	Shared	100	33.3333	No	No	No	No	5	5
194	3x49	I2	Shared	100	100	No	No	Yes	Yes	9	6
195	3x51	3x55	Shared	100	100	Yes	No	Yes	Yes	8	7
196	3x51	5x57	Shared	100	100	Yes	No	No	No	8	7
197	3x51	5x60	Shared	100	100	Yes	No	No	No	8	4
198	3x54	5x65	Shared	100	100	No	No	No	Yes	8	8
199	3x55	3x56	Shared	100	100	Yes	Yes	No	No	7	6
200	3x55	5x64	Shared	100	100	Yes	Yes	No	No	7	5
201	3x56	I2	Shared	100	100	No	No	Yes	Yes	6	6
202	4x59	4x63	Shared	100	100	No	No	No	No	4	4
203	4x60	5x39	Shared	100	100	No	No	Yes	Yes	8	6
204	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	No	6	4
205	4x61	5x39	Shared	100	100	Yes	Yes	Yes	Yes	6	6
206	4x63	4x64	Shared	100	100	No	No	No	No	4	5
207	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
208	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
209	E2	E2x52	Shared	100	100	Yes	Yes	Yes	No	3	4
210	5x36	E2	Shared	100	100	No	No	Yes	Yes	4	3
211	5x39	E2	Shared	100	100	Yes	Yes	Yes	Yes	6	3
212	5x35	E2	Shared	100	100	No	No	Yes	Yes	4	3
213	5x33	5x36	Shared	100	100	No	No	No	No	2	4
214	5x39	5x43	Shared	100	100	Yes	Yes	Yes	No	6	5
215	5x40	6x59	Shared	100	100	No	No	No	No	5	5
216	5x44	6x52	Shared	100	100	No	No	Yes	No	6	7
217	5x44	6x56	Shared	100	100	No	No	No	No	6	5
218	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	4
219	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
220	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	5
221	5x47	6x52	Shared	100	100	Yes	Yes	Yes	No	8	7
222	5x56	5x60	Shared	100	100	No	No	No	No	4	4
223	5x58	6x37	Shared	100	100	No	Yes	No	No	9	8
224	5x66	6x31	Shared	100	100	No	No	No	No	4	5
225	6x36	7x56	Shared	100	100	No	No	No	No	8	7
226	6x40	7x52	Shared	100	33.3333	Yes	No	No	No	7	8
227	6x43	7x48	Shared	100	100	No	No	No	No	6	5
228	6x44	6x48	Shared	100	100	No	Yes	Yes	Yes	9	8
229	6x47	7x40	Shared	100	100	No	No	No	No	8	7
230	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
231	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
232	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
233	6x49	6x53	Shared	100	100	No	No	No	No	5	6
234	6x50	7x37	Shared	100	100	No	No	No	No	9	6
235	6x51	6x55	Shared	100	100	Yes	Yes	No	Yes	7	6
236	6x51	7x41	Shared	100	100	Yes	Yes	No	No	7	7
237	6x54	6x55	Shared	100	100	Yes	Yes	No	Yes	4	6
238	6x54	7x34	Shared	100	100	Yes	Yes	No	Yes	4	5
239	6x54	7x37	Shared	100	100	Yes	Yes	No	No	4	6
240	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
241	7x34	7x38	Shared	100	100	No	Yes	No	Yes	5	5
242	7x43	7x48	Shared	100	100	No	No	No	No	5	5
243	7x47	7x48	Shared	100	100	No	Yes	No	No	7	5
244	7x49	7x53	Shared	100	100	No	No	Yes	Yes	9	9
245	7x53	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
246	7x54	8x54	Shared	100	100	No	No	No	No	7	6
247	8x47	8x49	Shared	100	100	No	No	No	Yes	8	6
248	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
249	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
250	8x48	8x51	Shared	25	100	No	Yes	No	No	4	8
251	1x43	2x58	Shared	75	0	No	No	No	No	6	7
252	5x32	5x34	Shared	25	100	No	No	No	No	3	1
253	1x31	NT	Shared	25	100	No	Yes	No	Yes	2	4
254	8x49	I1x49	Shared	50	33.3333	No	Yes	No	No	6	5
255	3x54	5x61	Shared	25	100	No	No	No	No	8	8
256	4x38	4x41	Shared	50	33.3333	No	No	No	No	7	4
257	5x49	5x50	Shared	50	0	No	No	No	No	5	9
258	6x58	E3	Shared	50	100	No	No	Yes	Yes	4	3
259	3x33	4x57	Shared	50	100	Yes	Yes	No	No	5	7
260	4x38	4x40	Shared	50	100	No	No	No	No	7	4
261	5x65	6x30	Shared	25	100	No	Yes	No	No	8	7
262	3x41	4x49	Shared	25	100	No	No	No	No	5	7
263	2x68	E2	Shared	25	100	No	Yes	Yes	Yes	4	3
264	4x41	I2	Shared	50	0	No	No	Yes	Yes	4	6
265	5x51	6x45	Shared	25	100	No	No	No	No	6	5
266	4x48	4x52	Shared	0	0	No	No	No	No	3	4
267	1x46	2x54	Shared	50	33.3333	No	No	No	No	8	6
268	7x32	NT	Shared	25	100	No	No	No	Yes	1	4
269	2x53	3x35	Shared	25	33.3333	No	Yes	No	No	7	8
270	1x43	2x59	Shared	25	33.3333	No	No	No	No	6	8
271	1x55	8x57	Shared	25	0	Yes	Yes	No	No	4	4
272	5x49	5x53	Shared	0	100	No	No	No	No	5	6
273	2x56	3x27	Shared	25	100	No	Yes	No	No	5	4
274	1x36	2x62	Shared	0	33.3333	No	No	No	Yes	6	6
275	1x35	7x36	Shared	0	33.3333	Yes	Yes	No	No	4	5
276	5x59	5x63	Shared	0	0	No	No	No	No	3	3
277	3x34	4x53	Shared	0	33.3333	No	No	No	No	5	8
278	6x54	7x30	Shared	0	100	Yes	Yes	No	No	4	4
279	5x34	5x38	Shared	0	0	No	No	No	No	1	4
280	4x51	4x55	Shared	0	0	No	No	No	No	3	4
281	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	8
282	6x38	6x42	Shared	0	0	No	No	No	No	5	4
283	4x44	4x48	Shared	0	0	No	No	No	No	3	3
284	1x41	1x45	Shared	0	0	No	No	Yes	No	5	4
285	5x55	5x59	Shared	0	33.3333	No	No	No	No	4	3
286	1x40	1x44	Shared	0	0	No	No	No	No	4	4
287	8x52	8x55	Shared	0	0	No	No	No	No	4	5
288	NT	NT	tachykinin_on	0	100	No	Yes	No	Yes	4	4
289	2x68	NT	tachykinin_on	0	100	No	Yes	No	Yes	4	4
290	E2	NT	tachykinin_on	0	100	Yes	Yes	No	Yes	3	4
291	7x28	NT	tachykinin_on	0	100	No	No	No	Yes	2	4
292	Lig	NT	tachykinin_on	0	100	Yes	Yes	No	Yes	0	4
293	7x31	NT	tachykinin_on	0	100	No	No	No	Yes	4	4
294	1x32	NT	tachykinin_on	0	100	No	No	No	Yes	3	4
295	1x35	1x39	tachykinin_on	0	100	Yes	Yes	No	Yes	4	7
296	1x35	7x32	tachykinin_on	0	100	Yes	Yes	No	No	4	1
297	1x39	7x35	tachykinin_on	0	100	No	Yes	No	Yes	7	3
298	1x53	8x50	tachykinin_on	0	100	No	No	Yes	Yes	8	9
299	1x54	2x47	tachykinin_on	0	100	No	No	No	No	7	9
300	1x58	I1x51	tachykinin_on	0	100	No	No	No	No	2	6
301	2x37	2x39	tachykinin_on	0	100	No	No	No	No	7	8
302	2x38	I2	tachykinin_on	0	100	No	No	Yes	Yes	6	6
303	2x39	2x40	tachykinin_on	0	100	No	No	No	Yes	8	8
304	2x39	I2	tachykinin_on	0	100	No	No	Yes	Yes	8	6
305	2x40	2x43	tachykinin_on	0	100	No	Yes	No	No	8	8
306	2x42	3x49	tachykinin_on	0	100	Yes	Yes	No	No	7	9
307	2x46	2x50	tachykinin_on	0	100	No	No	Yes	Yes	9	9
308	2x46	3x42	tachykinin_on	0	100	No	No	No	No	9	8
309	2x46	7x49	tachykinin_on	0	100	No	No	No	No	9	9
310	2x49	3x39	tachykinin_on	0	100	No	No	No	No	8	9
311	2x52	2x56	tachykinin_on	0	100	No	No	No	Yes	6	5
312	2x52	3x31	tachykinin_on	0	100	No	No	No	Yes	6	4
313	2x53	3x36	tachykinin_on	0	100	No	Yes	No	No	7	7
314	2x53	3x39	tachykinin_on	0	100	No	Yes	No	No	7	9
315	2x53	7x42	tachykinin_on	0	100	No	Yes	No	No	7	7
316	2x53	7x46	tachykinin_on	0	100	No	Yes	No	No	7	9
317	2x56	3x31	tachykinin_on	0	100	No	Yes	No	Yes	5	4
318	2x57	2x61	tachykinin_on	0	100	Yes	Yes	No	Yes	6	6
319	2x57	3x28	tachykinin_on	0	100	Yes	Yes	No	Yes	6	5
320	2x57	7x38	tachykinin_on	0	100	Yes	Yes	No	Yes	6	5
321	2x57	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	6	0
322	2x60	E1x52	tachykinin_on	0	100	No	No	No	No	5	7
323	2x60	3x28	tachykinin_on	0	100	No	No	No	Yes	5	5
324	2x61	7x34	tachykinin_on	0	100	No	Yes	No	Yes	6	5
325	2x61	7x38	tachykinin_on	0	100	No	Yes	No	Yes	6	5
326	2x61	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	6	0
327	2x62	7x35	tachykinin_on	0	100	No	Yes	No	Yes	6	3
328	2x64	2x68	tachykinin_on	0	100	No	Yes	No	Yes	4	4
329	2x64	E2	tachykinin_on	0	100	No	Yes	Yes	Yes	4	3
330	2x64	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	4	0
331	2x66	2x67	tachykinin_on	0	100	No	No	No	No	5	5
332	2x68	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	4	0
333	3x24	E1x52	tachykinin_on	0	100	No	Yes	No	No	5	7
334	3x24	3x27	tachykinin_on	0	100	No	Yes	No	No	5	4
335	3x25	4x65	tachykinin_on	0	100	No	No	No	Yes	9	5
336	3x25	E2	tachykinin_on	0	100	No	No	Yes	Yes	9	3
337	3x26	4x65	tachykinin_on	0	100	No	No	No	Yes	6	5
338	3x28	3x32	tachykinin_on	0	100	No	Yes	No	No	5	6
339	3x28	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	5	0
340	3x29	3x33	tachykinin_on	0	100	Yes	Yes	Yes	Yes	5	5
341	3x29	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	5	0
342	3x30	4x59	tachykinin_on	0	100	No	No	No	No	6	4
343	3x31	3x32	tachykinin_on	0	100	No	Yes	No	No	4	6
344	3x31	4x50	tachykinin_on	0	100	No	Yes	Yes	No	4	9
345	3x33	3x37	tachykinin_on	0	100	Yes	Yes	Yes	Yes	5	7
346	3x34	4x54	tachykinin_on	0	100	No	No	No	No	5	4
347	3x36	3x37	tachykinin_on	0	100	No	No	Yes	Yes	7	7
348	3x37	4x56	tachykinin_on	0	100	Yes	Yes	No	No	7	5
349	3x40	6x48	tachykinin_on	0	100	No	No	Yes	Yes	7	8
350	3x44	5x53	tachykinin_on	0	100	No	No	No	No	7	6
351	3x46	3x50	tachykinin_on	0	100	No	No	No	No	9	9
352	3x50	5x58	tachykinin_on	0	100	No	No	No	Yes	9	9
353	3x50	7x53	tachykinin_on	0	100	No	No	Yes	Yes	9	9
354	3x52	3x56	tachykinin_on	0	100	No	No	No	No	5	6
355	3x55	5x60	tachykinin_on	0	100	Yes	Yes	No	No	7	4
356	4x42	I2	tachykinin_on	0	100	No	Yes	Yes	Yes	7	6
357	E2	E2x50	tachykinin_on	0	100	Yes	Yes	No	No	3	9
358	E2	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	3	0
359	E2x50	Lig	tachykinin_on	0	100	No	No	Yes	Yes	9	0
360	E2x51	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	4	0
361	5x34	E2	tachykinin_on	0	100	No	No	Yes	Yes	1	3
362	5x36	6x59	tachykinin_on	0	100	No	No	No	No	4	5
363	5x37	5x41	tachykinin_on	0	100	No	No	No	No	3	5
364	5x39	5x40	tachykinin_on	0	100	Yes	Yes	No	No	6	5
365	5x40	6x55	tachykinin_on	0	100	No	No	No	Yes	5	6
366	5x43	5x461	tachykinin_on	0	100	Yes	No	Yes	No	5	6
367	5x51	6x44	tachykinin_on	0	100	No	No	No	Yes	6	9
368	5x62	6x34	tachykinin_on	0	100	No	No	No	No	5	6
369	5x65	6x33	tachykinin_on	0	100	No	Yes	No	No	8	7
370	5x66	6x34	tachykinin_on	0	100	No	No	No	No	4	6
371	6x23	6x26	tachykinin_on	0	100	No	No	No	No	0	4
372	6x32	7x56	tachykinin_on	0	100	No	No	No	No	8	7
373	6x36	7x52	tachykinin_on	0	100	No	No	No	No	8	8
374	6x51	6x52	tachykinin_on	0	100	Yes	Yes	Yes	No	7	7
375	6x51	7x38	tachykinin_on	0	100	Yes	Yes	No	Yes	7	5
376	6x54	E3	tachykinin_on	0	100	Yes	Yes	Yes	Yes	4	3
377	6x54	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	4	0
378	6x60	6x61	tachykinin_on	0	100	No	No	No	No	5	4
379	7x29	E3	tachykinin_on	0	100	No	No	Yes	Yes	3	3
380	E3	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	3	0
381	7x30	Lig	tachykinin_on	0	100	No	No	Yes	Yes	4	0
382	7x31	7x32	tachykinin_on	0	100	No	No	No	No	4	1
383	7x31	Lig	tachykinin_on	0	100	No	No	Yes	Yes	4	0
384	7x34	Lig	tachykinin_on	0	100	No	Yes	Yes	Yes	5	0
385	7x38	7x42	tachykinin_on	0	100	No	Yes	No	No	5	7
386	Lig	Lig	tachykinin_on	0	100	Yes	Yes	Yes	Yes	0	0
387	1x52	1x55	tachykinin_on	0	100	No	No	Yes	Yes	6	4
388	1x56	8x48	tachykinin_on	0	100	No	No	No	Yes	8	4
389	2x37	I2	tachykinin_on	0	100	No	No	Yes	Yes	7	6
390	3x24	3x28	tachykinin_on	0	100	No	Yes	No	Yes	5	5
391	4x43	4x46	tachykinin_on	0	100	No	No	No	Yes	2	8
392	5x54	6x44	tachykinin_on	0	100	No	No	No	Yes	8	9
393	7x28	Lig	tachykinin_on	0	100	No	No	Yes	Yes	2	0
394	8x47	8x48	tachykinin_on	0	100	No	No	No	Yes	8	4
395	E1x50	E2x51	tachykinin_on	0	100	Yes	Yes	No	Yes	8	4
396	3x25	E2x51	tachykinin_on	0	100	No	No	No	Yes	9	4
397	3x29	E2x51	tachykinin_on	0	100	Yes	Yes	No	Yes	5	4
398	4x65	E2x51	tachykinin_on	0	100	No	Yes	No	Yes	5	4
399	8x48	8x49	tachykinin_on	0	100	No	Yes	No	Yes	4	6
400	2x65	7x35	tachykinin_on	0	33.3333	No	No	No	Yes	5	3
401	5x61	6x37	tachykinin_on	0	33.3333	No	No	No	No	8	8
402	7x39	7x40	tachykinin_on	0	33.3333	Yes	Yes	No	No	5	7
403	5x65	6x34	tachykinin_on	0	33.3333	No	Yes	No	No	8	6
404	5x31	5x35	tachykinin_on	0	33.3333	No	No	No	No	1	4
405	1x42	7x47	tachykinin_on	0	33.3333	No	No	No	Yes	7	7
406	5x58	6x41	tachykinin_on	0	33.3333	No	Yes	No	No	9	8
407	2x63	E1x51	tachykinin_on	0	33.3333	No	No	No	No	4	2
408	3x43	5x54	tachykinin_on	0	33.3333	No	No	No	No	8	8
409	6x36	6x37	tachykinin_on	0	66.6667	No	No	No	No	8	8
410	3x41	5x461	tachykinin_on	0	33.3333	No	No	Yes	No	5	6
411	3x41	5x46	tachykinin_on	0	0	No	No	No	No	5	4
412	2x38	4x39	tachykinin_on	0	0	No	No	No	No	6	2
413	6x26	6x30	tachykinin_on	0	33.3333	No	No	No	No	4	7
414	6x32	7x55	tachykinin_on	0	33.3333	No	No	No	No	8	6
415	1x43	1x47	tachykinin_on	0	33.3333	No	No	No	No	6	6
416	1x31	1x34	tachykinin_on	0	66.6667	No	Yes	No	No	2	4
417	5x37	6x60	tachykinin_on	0	33.3333	No	No	No	No	3	5
418	7x30	7x33	tachykinin_on	0	0	No	No	No	No	4	5
419	5x49	5x52	tachykinin_on	0	33.3333	No	No	No	No	5	3
420	5x63	5x67	tachykinin_on	0	33.3333	No	No	No	No	3	4
421	6x27	6x30	tachykinin_on	0	33.3333	No	No	No	No	2	7
422	6x57	E3	tachykinin_on	0	0	No	No	Yes	Yes	4	3
423	1x51	2x51	tachykinin_on	0	33.3333	No	No	No	No	4	7
424	6x39	6x43	tachykinin_on	0	0	No	No	No	No	5	6
425	5x45	5x46	tachykinin_on	0	0	No	No	No	No	4	4
426	6x28	6x31	tachykinin_on	0	33.3333	No	No	No	No	4	5
427	5x55	6x41	tachykinin_on	0	0	No	No	No	No	4	8
428	4x46	4x47	tachykinin_on	0	33.3333	No	Yes	No	No	8	3
429	5x66	6x35	tachykinin_on	0	0	No	No	No	No	4	6
430	5x68	6x26	tachykinin_on	0	33.3333	No	No	No	No	5	4
431	6x23	6x25	tachykinin_on	0	0	No	No	No	No	0	3
432	5x42	5x46	tachykinin_on	0	0	No	No	No	No	4	4
433	1x44	1x48	tachykinin_on	0	0	No	No	No	No	4	4
434	6x35	6x38	tachykinin_on	0	33.3333	No	No	No	No	6	5
435	7x47	7x51	tachykinin_on	0	0	No	Yes	No	No	7	7
436	6x46	6x47	tachykinin_on	0	0	No	No	No	No	5	8
437	4x55	4x56	tachykinin_on	0	0	No	No	No	No	4	5
438	4x52	4x56	tachykinin_on	0	0	No	No	No	No	4	5
439	1x34	1x37	tachykinin_on	0	0	No	No	No	No	4	5
440	3x22	3x23	tachykinin_on	0	0	No	No	No	No	3	3
441	8x49	8x52	tachykinin_on	0	0	No	Yes	No	No	6	4
442	8x51	8x52	tachykinin_on	0	0	No	No	No	No	8	4

Orange: nodes, hubs and links specific of tachykinin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of tachykinin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	tachykinin_off Avg Int. Strength	tachykinin_on Avg Int. Strength	tachykinin_off Num Of Links	tachykinin_on Num Of Links	ConSurf
1	1x45	tachykinin_off	0	0	4	2	4
2	1x50	tachykinin_off	75	33.3333	5	3	9
3	I1x50	tachykinin_off	25	0	4	3	7
4	2x41	tachykinin_off	25	0	4	3	5
5	3x51	tachykinin_off	75	66.6667	5	3	8
6	4x50	tachykinin_off	25	33.3333	4	3	9
7	E2x52	tachykinin_off	50	0	5	2	4
8	5x43	tachykinin_off	75	33.3333	4	2	5
9	5x461	tachykinin_off	25	0	4	3	6
10	6x40	tachykinin_off	25	0	4	1	7
11	6x52	tachykinin_off	75	66.6667	4	3	7
12	CT	tachykinin_off	25	0	4	0	5
13	Lig	Shared	100	100	13	22	0
14	1x35	Shared	0	66.6667	4	4	4
15	1x55	Shared	25	0	4	5	4
16	2x42	Shared	100	100	5	5	7
17	2x50	Shared	100	100	4	5	9
18	2x57	Shared	75	66.6667	4	5	6
19	E1x50	Shared	75	66.6667	8	5	8
20	3x29	Shared	25	33.3333	4	5	5
21	3x33	Shared	75	66.6667	4	5	5
22	3x37	Shared	0	66.6667	4	4	7
23	3x55	Shared	0	66.6667	4	4	7
24	I2	Shared	100	100	7	7	6
25	4x61	Shared	100	33.3333	5	5	6
26	E2	Shared	100	100	13	15	3
27	5x39	Shared	75	66.6667	4	5	6
28	5x47	Shared	100	66.6667	4	4	8
29	6x48	Shared	75	100	6	6	8
30	6x51	Shared	75	100	4	6	7
31	6x54	Shared	0	100	4	6	4
32	E3	Shared	25	100	5	8	3
33	7x39	Shared	75	0	5	4	5
34	7x53	Shared	100	33.3333	5	4	9
35	8x50	Shared	75	33.3333	5	4	9
36	NT	tachykinin_on	25	66.6667	2	10	4
37	1x31	tachykinin_on	0	0	3	4	2
38	1x39	tachykinin_on	50	66.6667	3	4	7
39	2x40	tachykinin_on	0	33.3333	3	4	8
40	2x53	tachykinin_on	50	100	2	5	7
41	2x56	tachykinin_on	0	33.3333	2	4	5
42	2x61	tachykinin_on	25	100	1	5	6
43	2x62	tachykinin_on	25	0	3	4	6
44	2x64	tachykinin_on	0	100	1	4	4
45	2x68	tachykinin_on	0	33.3333	1	4	4
46	3x24	tachykinin_on	25	33.3333	3	4	5
47	3x28	tachykinin_on	25	66.6667	3	6	5
48	3x31	tachykinin_on	25	100	2	5	4
49	4x42	tachykinin_on	0	66.6667	3	4	7
50	4x46	tachykinin_on	0	0	2	4	8
51	4x65	tachykinin_on	0	33.3333	2	4	5
52	E2x51	tachykinin_on	0	33.3333	1	5	4
53	5x58	tachykinin_on	25	33.3333	3	4	9
54	5x65	tachykinin_on	0	0	3	4	8
55	6x44	tachykinin_on	0	33.3333	2	4	9
56	6x55	tachykinin_on	25	66.6667	3	4	6
57	7x34	tachykinin_on	0	66.6667	3	4	5
58	7x35	tachykinin_on	0	33.3333	1	4	3
59	7x38	tachykinin_on	75	66.6667	2	5	5
60	7x47	tachykinin_on	0	0	2	4	7
61	8x48	tachykinin_on	0	33.3333	2	4	4
62	8x49	tachykinin_on	0	0	3	5	6

Orange: nodes, hubs and links specific of tachykinin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of tachykinin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	tachykinin_off Recurrence	tachykinin_on Recurrence	tachykinin_off Hub1?	tachykinin_on Hub1?	tachykinin_off Hub2?	tachykinin_on Hub2?	ConSurf1	ConSurf2
1	3x32	Lig	tachykinin_off	10.8633	0	No	No	Yes	Yes	6	0
2	E2x52	Lig	tachykinin_off	29.1208	0	Yes	No	Yes	Yes	4	0
3	5x461	Lig	tachykinin_off	14.7424	0	Yes	No	Yes	Yes	6	0
4	6x48	Lig	tachykinin_off	11.9555	0	Yes	Yes	Yes	Yes	8	0
5	6x55	Lig	tachykinin_off	90.1201	0.653587	No	Yes	Yes	Yes	6	0
6	1x35	7x39	tachykinin_off	12.1522	0	Yes	Yes	Yes	Yes	4	5
7	1x39	7x38	tachykinin_off	99.9874	0	No	Yes	No	Yes	7	5
8	6x54	7x34	tachykinin_off	99.7489	2.28208	Yes	Yes	No	Yes	4	5
9	6x54	6x55	tachykinin_off	98.8032	0.150921	Yes	Yes	No	Yes	4	6
10	7x43	7x48	tachykinin_off	98.1755	2.89672	No	No	No	No	5	5
11	7x39	7x43	tachykinin_off	98.3554	0	Yes	Yes	No	No	5	5
12	6x40	7x49	tachykinin_off	62.3258	0	Yes	No	No	No	7	9
13	6x40	7x52	tachykinin_off	95.6438	1.81471	Yes	No	No	No	7	8
14	6x43	7x52	tachykinin_off	96.1794	0	No	No	No	No	6	8
15	6x43	7x48	tachykinin_off	96.4347	5.79222	No	No	No	No	6	5
16	1x56	8x54	tachykinin_off	11.2274	0	No	No	No	No	8	6
17	1x56	8x50	tachykinin_off	13.6879	5.80804	No	No	Yes	Yes	8	9
18	8x50	I1x50	tachykinin_off	16.7552	0	Yes	Yes	Yes	No	9	7
19	6x37	6x40	tachykinin_off	62.3258	0	No	No	Yes	No	8	7
20	3x47	5x58	tachykinin_off	58.5555	1.81592	No	No	No	Yes	9	9
21	3x47	5x57	tachykinin_off	55.1073	0	No	No	No	No	9	7
22	3x51	5x57	tachykinin_off	54.2244	0.912831	Yes	No	No	No	8	7
23	3x51	3x56	tachykinin_off	35.0714	0	Yes	No	No	No	8	6
24	3x56	I2	tachykinin_off	35.9752	7.56311	No	No	Yes	Yes	6	6
25	3x49	I2	tachykinin_off	27.447	5.40274	No	No	Yes	Yes	9	6
26	2x38	3x49	tachykinin_off	25.3086	0	No	No	No	No	6	9
27	2x38	4x42	tachykinin_off	24.3922	1.09661	No	No	No	Yes	6	7
28	2x42	4x42	tachykinin_off	16.2112	6.99593	Yes	Yes	No	Yes	7	7
29	E1x50	E2	tachykinin_off	19.9146	0	Yes	Yes	Yes	Yes	8	3
30	E2	E2x52	tachykinin_off	25.8024	0.264112	Yes	Yes	Yes	No	3	4
31	5x36	E2	tachykinin_off	24.8776	3.12188	No	No	Yes	Yes	4	3
32	5x36	Lig	tachykinin_off	26.4343	0	No	No	Yes	Yes	4	0
33	3x37	5x461	tachykinin_off	13.3406	3.7353	Yes	Yes	Yes	No	7	6
34	3x51	3x55	tachykinin_off	16.4247	1.81958	Yes	No	Yes	Yes	8	7
35	3x54	3x55	tachykinin_off	16.0187	0	No	No	Yes	Yes	8	7
36	5x31	E2	tachykinin_off	10.8131	0	No	No	Yes	Yes	1	3
37	1x39	7x39	Shared	99.8075	40.2327	No	Yes	Yes	Yes	7	5
38	7x34	7x38	Shared	100	20.322	No	Yes	No	Yes	5	5
39	1x50	2x50	Shared	10.0975	14.5164	Yes	No	Yes	Yes	9	9
40	2x50	7x49	Shared	16.2615	99.8819	Yes	Yes	No	No	9	9
41	7x53	8x50	Shared	40.2519	19.492	Yes	Yes	Yes	Yes	9	9
42	7x49	7x53	Shared	50.2281	100	No	No	Yes	Yes	9	9
43	1x60	I1x50	Shared	11.2483	13.4478	No	No	Yes	No	5	7
44	5x58	6x37	Shared	60.8612	42.5623	No	Yes	No	No	9	8
45	2x42	4x46	Shared	10.1728	13.9383	Yes	Yes	No	Yes	7	8
46	3x54	5x65	Shared	11.1813	27.0685	No	No	No	Yes	8	8
47	1x32	NT	tachykinin_on	0	10.926	No	No	No	Yes	3	4
48	1x35	7x32	tachykinin_on	0	53.8777	Yes	Yes	No	No	4	1
49	7x32	NT	tachykinin_on	2.33084	29.1729	No	No	No	Yes	1	4
50	1x35	1x39	tachykinin_on	0	42.8422	Yes	Yes	No	Yes	4	7
51	1x42	7x39	tachykinin_on	1.29723	25.8769	No	No	Yes	Yes	7	5
52	1x42	7x47	tachykinin_on	0	22.9985	No	No	No	Yes	7	7
53	2x53	7x46	tachykinin_on	0	60.8128	No	Yes	No	No	7	9
54	2x53	3x36	tachykinin_on	0	47.2335	No	Yes	No	No	7	7
55	3x36	3x37	tachykinin_on	0	24.0513	No	No	Yes	Yes	7	7
56	3x33	3x37	tachykinin_on	0	22.2804	Yes	Yes	Yes	Yes	5	7
57	3x33	Lig	tachykinin_on	8.19768	20.316	Yes	Yes	Yes	Yes	5	0
58	Lig	NT	tachykinin_on	0	46.3402	Yes	Yes	No	Yes	0	4
59	3x36	6x48	tachykinin_on	2.09231	24.246	No	No	Yes	Yes	7	8
60	6x48	6x51	tachykinin_on	7.06783	22.7477	Yes	Yes	Yes	Yes	8	7
61	6x51	Lig	tachykinin_on	0.845294	40.4871	Yes	Yes	Yes	Yes	7	0
62	2x53	7x42	tachykinin_on	0	75.1077	No	Yes	No	No	7	7
63	7x38	7x42	tachykinin_on	0	76.7812	No	Yes	No	No	5	7
64	6x51	7x38	tachykinin_on	0	21.1655	Yes	Yes	No	Yes	7	5
65	2x57	7x38	tachykinin_on	0	19.7524	Yes	Yes	No	Yes	6	5
66	2x57	Lig	tachykinin_on	0	26.505	Yes	Yes	Yes	Yes	6	0
67	2x61	7x38	tachykinin_on	0	18.3418	No	Yes	No	Yes	6	5
68	2x61	Lig	tachykinin_on	0	17.8562	No	Yes	Yes	Yes	6	0
69	7x34	Lig	tachykinin_on	0	18.0838	No	Yes	Yes	Yes	5	0
70	2x50	3x39	tachykinin_on	1.29723	58.5514	Yes	Yes	No	No	9	9
71	2x53	3x39	tachykinin_on	0	59.9657	No	Yes	No	No	7	9
72	2x50	7x46	tachykinin_on	3.79964	58.6914	Yes	Yes	No	No	9	9
73	1x55	1x60	tachykinin_on	9.98452	11.6088	Yes	Yes	No	No	4	5
74	2x40	I1x50	tachykinin_on	2.81625	15.5838	No	Yes	Yes	No	8	7
75	2x40	2x43	tachykinin_on	0	26.0534	No	Yes	No	No	8	8
76	2x43	7x53	tachykinin_on	1.26794	27.3241	No	No	Yes	Yes	8	9
77	2x45	4x46	tachykinin_on	8.92999	17.6602	No	No	No	Yes	9	8
78	2x45	4x50	tachykinin_on	6.41922	18.1471	No	No	Yes	No	9	9
79	3x31	4x50	tachykinin_on	0	18.64	No	Yes	Yes	No	4	9
80	3x31	3x32	tachykinin_on	0	18.9114	No	Yes	No	No	4	6
81	2x57	3x32	tachykinin_on	9.66649	10.1324	Yes	Yes	No	No	6	6
82	8x47	8x50	tachykinin_on	4.14696	10.5718	No	No	Yes	Yes	8	9
83	4x63	4x64	tachykinin_on	2.30154	10.2395	No	No	No	No	4	5
84	4x64	E2	tachykinin_on	4.26413	11.2826	No	No	Yes	Yes	5	3
85	3x50	5x58	tachykinin_on	0	53.9483	No	No	No	Yes	9	9
86	3x50	7x53	tachykinin_on	0	56.5894	No	No	Yes	Yes	9	9
87	3x54	5x61	tachykinin_on	3.84986	28.8479	No	No	No	No	8	8
88	5x61	6x37	tachykinin_on	0	30.6212	No	No	No	No	8	8
89	5x65	6x34	tachykinin_on	0	14.4605	No	Yes	No	No	8	6
90	5x66	6x34	tachykinin_on	0	10.8651	No	No	No	No	4	6
91	6x36	6x37	tachykinin_on	0	10.8432	No	No	No	No	8	8
92	7x47	7x48	tachykinin_on	8.92999	11.5759	No	Yes	No	No	7	5
93	E2	Lig	tachykinin_on	0	24.6099	Yes	Yes	Yes	Yes	3	0
94	7x31	7x32	tachykinin_on	0	27.5529	No	No	No	No	4	1
95	7x31	Lig	tachykinin_on	0	28.6166	No	No	Yes	Yes	4	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
3x32	Lig	tachykinin_off	10.97	0	0	1	1	0
3x33	Lig	Shared	7.3725	8.39	1	1	1	0
4x61	Lig	Shared	16.56	7.25	1	1	1	0
E2x52	Lig	tachykinin_off	3.995	0	1	1	1	0
5x40	Lig	tachykinin_off	16.3425	0	0	0	1	0
5x43	Lig	tachykinin_off	3.8775	0	1	0	1	0
5x461	Lig	tachykinin_off	4.99	0	1	0	1	0
6x48	Lig	tachykinin_off	5.7075	0	1	1	1	0
6x51	Lig	Shared	18.08	8.07333	1	1	1	0
6x52	Lig	tachykinin_off	5.6375	0	1	0	1	0
6x55	Lig	Shared	17.67	10.4533	1	1	1	0
7x42	Lig	tachykinin_off	3.815	0	0	0	1	0
2x53	2x57	tachykinin_off	3.8575	0	0	0	2	1
2x57	3x27	tachykinin_off	6.3425	0	5	1	1	2
2x57	3x31	tachykinin_off	6.9475	0	5	1	1	2
2x57	3x32	Shared	7.735	5.97667	5	1	1	1
2x58	7x42	Shared	7.905	5.01667	0	0	2	1
2x60	3x24	Shared	9.465	8.55667	0	1	2	2
2x61	3x28	Shared	8.925	8.65	0	1	1	1
2x64	E1x50	Shared	10.61	8.68333	0	1	1	2
2x67	E1x49	Shared	7.695	3.28	1	0	2	2
E1x49	E2	tachykinin_off	9.8875	0	1	0	2	1
3x24	E1x50	tachykinin_off	4.3425	0	0	1	2	2
3x25	E1x50	tachykinin_off	4.57	0	1	1	2	2
3x28	E1x50	tachykinin_off	8.2025	0	0	1	1	2
E1x50	E2	tachykinin_off	3.965	0	1	0	2	1
E1x50	E2x50	Shared	11.1025	5.22333	1	0	2	1
3x22	E2	Shared	5.8975	5.05	1	1	2	1
3x25	E2x50	tachykinin_off	7.28	0	1	1	2	1
3x27	3x31	Shared	14.47	8.21667	5	1	2	2
3x28	3x29	tachykinin_off	6.3775	0	0	1	1	1
3x29	4x61	Shared	5.28	4.84	1	1	1	1
3x29	4x65	Shared	6.3325	5.46333	1	1	1	2
3x29	E2x52	tachykinin_off	9.205	0	1	1	1	1
3x33	4x61	Shared	5.1475	4.11667	1	1	1	1
3x33	5x43	tachykinin_off	4.61	0	1	1	1	1
3x36	5x461	tachykinin_off	4.8475	0	0	0	2	1
3x36	6x48	Shared	6.5	4.8	0	0	2	1
3x37	3x41	tachykinin_off	18.31	0	0	0	2	2
3x37	5x461	Shared	3.77	11.85	0	0	2	1
3x40	6x44	Shared	11.3025	6.7	0	1	2	2
4x56	5x43	tachykinin_off	3.725	0	0	0	2	1
4x61	E2x52	Shared	6.5175	4.67333	1	1	1	1
4x61	5x39	Shared	9.58	9.02	1	1	1	2
4x64	E2	Shared	15.8225	10.3	1	1	2	1
4x65	E2x52	tachykinin_off	4.2575	0	1	1	2	1
E2	E2	Shared	43.635	38.5767	1	1	1	1
E2	E2x51	tachykinin_off	9.9025	0	1	1	1	1
E2	E2x52	Shared	6.7525	5.87333	1	1	1	1
5x36	E2	Shared	18.305	16.0567	1	1	1	1
5x39	E2	Shared	6.27	7.39333	1	1	2	1
5x31	E2	tachykinin_off	4.5775	0	1	0	2	1
5x35	E2	Shared	6.4075	6.01333	0	1	2	1
5x33	5x36	Shared	7.0875	4.05	0	0	2	1
5x39	5x43	Shared	6.6225	6.73	1	1	2	1
5x40	6x56	tachykinin_off	5.145	0	0	0	1	2
5x40	6x59	Shared	7.6225	5.08	0	0	1	2
5x44	6x52	Shared	9.24	8.96667	0	0	2	1
5x44	6x56	Shared	3.6825	3.44	0	0	2	2
5x461	6x52	tachykinin_off	4.3075	0	1	0	1	1
5x47	6x52	Shared	7.6225	4.35667	0	0	2	1
6x44	6x48	Shared	9.77	8.68667	0	1	2	1
6x48	6x51	Shared	8.7675	7.53333	1	1	1	1
6x48	7x41	Shared	5.835	6.48333	1	1	1	2
6x48	7x45	Shared	7.1025	5.76333	1	1	1	2
6x51	6x55	Shared	8.8425	10.12	1	1	1	1
6x51	7x41	Shared	4.5075	4.94667	1	1	1	2
6x54	6x55	Shared	8.8425	7.69667	0	1	1	1
6x54	7x34	Shared	8.2525	12.69	0	1	1	1
6x54	7x37	Shared	3.765	3.36	0	1	1	2
6x57	6x58	tachykinin_off	4.105	0	0	0	2	2
6x61	E3	Shared	6.36	3.65333	0	1	2	1
7x29	7x32	tachykinin_off	10.25	0	0	0	2	2
7x34	7x38	Shared	7.7825	11.9	0	1	1	2
5x36	Lig	tachykinin_off	4.31	0	1	1	1	0
E3	E3	Shared	6.74	9.27	6	1	1	1
1x31	NT	Shared	3.52	4.89667	3	1	2	1
7x30	E3	tachykinin_off	3.485	0	6	1	1	1
6x58	E3	Shared	3.2525	9.93	6	0	2	1
3x33	4x57	Shared	3.25	3.25	1	1	1	2
5x31	5x34	tachykinin_off	2.9625	0	1	0	2	2
2x68	E2	Shared	2.85	6.96333	0	1	1	1
7x33	7x37	tachykinin_off	2.6875	0	0	0	2	2
7x32	NT	Shared	2.56	3.46667	0	1	2	1
2x65	7x34	tachykinin_off	1.6675	0	0	0	2	1
6x54	7x30	Shared	1.57	6.91	0	1	1	1
2x67	7x31	tachykinin_off	1.545	0	1	0	2	1
NT	NT	tachykinin_on	0	14.1567	0	1	1	1
2x68	NT	tachykinin_on	0	4.18333	0	1	1	1
E2	NT	tachykinin_on	0	7.36	1	1	1	1
7x28	NT	tachykinin_on	0	8.55	0	1	1	1
Lig	NT	tachykinin_on	0	9.38333	1	1	0	1
7x31	NT	tachykinin_on	0	12.89	0	1	1	1
1x32	NT	tachykinin_on	0	6.01333	0	1	2	1
2x53	3x36	tachykinin_on	0	4.00333	0	0	2	2
2x53	7x42	tachykinin_on	0	3.85	0	0	2	1
2x57	2x61	tachykinin_on	0	4.54333	5	1	1	1
2x57	3x28	tachykinin_on	0	3.41667	5	1	1	1
2x57	7x38	tachykinin_on	0	4.22	5	1	1	2
2x57	Lig	tachykinin_on	0	3.4	5	1	1	0
2x60	3x28	tachykinin_on	0	10.14	0	1	2	1
2x61	7x34	tachykinin_on	0	4.26667	0	1	1	1
2x61	7x38	tachykinin_on	0	3.48	0	1	1	2
2x61	Lig	tachykinin_on	0	5.71	0	1	1	0
2x64	2x68	tachykinin_on	0	3.6	0	1	1	1
2x64	E2	tachykinin_on	0	8.75333	0	1	1	1
2x64	Lig	tachykinin_on	0	8.54	0	1	1	0
2x68	Lig	tachykinin_on	0	5.71333	0	1	1	0
3x24	3x27	tachykinin_on	0	7.60667	0	1	2	2
3x25	4x65	tachykinin_on	0	3.44	1	1	2	2
3x25	E2	tachykinin_on	0	6.21	1	1	2	1
3x28	3x32	tachykinin_on	0	6.71667	0	1	1	1
3x28	Lig	tachykinin_on	0	4.27667	0	1	1	0
3x29	3x33	tachykinin_on	0	3.30667	1	1	1	1
3x29	Lig	tachykinin_on	0	5.49333	1	1	1	0
3x31	3x32	tachykinin_on	0	3.85	5	1	2	1
3x33	3x37	tachykinin_on	0	4.60333	1	1	1	2
3x36	3x37	tachykinin_on	0	4.67	0	0	2	2
3x37	4x56	tachykinin_on	0	6.90333	0	0	2	2
3x40	6x48	tachykinin_on	0	8.22	0	1	2	1
E2	E2x50	tachykinin_on	0	4.33333	1	1	1	1
E2	Lig	tachykinin_on	0	18.6067	1	1	1	0
E2x50	Lig	tachykinin_on	0	3.21667	1	1	1	0
E2x51	Lig	tachykinin_on	0	9.4	0	1	1	0
5x34	E2	tachykinin_on	0	3.32667	0	1	2	1
5x36	6x59	tachykinin_on	0	5.67	1	1	1	2
5x39	5x40	tachykinin_on	0	7.98333	1	1	2	1
5x40	6x55	tachykinin_on	0	6.78667	0	0	1	1
5x43	5x461	tachykinin_on	0	4.14	1	0	1	1
6x51	6x52	tachykinin_on	0	7.33	1	1	1	1
6x51	7x38	tachykinin_on	0	3.92667	1	1	1	2
6x54	E3	tachykinin_on	0	6.85333	0	1	1	1
6x54	Lig	tachykinin_on	0	3.76333	0	1	1	0
7x29	E3	tachykinin_on	0	9.03333	0	0	2	1
E3	Lig	tachykinin_on	0	8.49667	6	1	1	0
7x30	Lig	tachykinin_on	0	4.18667	6	1	1	0
7x31	7x32	tachykinin_on	0	4.26667	0	1	1	2
7x31	Lig	tachykinin_on	0	4.68333	0	1	1	0
7x34	Lig	tachykinin_on	0	11.89	0	1	1	0
7x38	7x42	tachykinin_on	0	7.73	0	1	2	1
3x24	3x28	tachykinin_on	0	4.23667	0	1	2	1
7x28	Lig	tachykinin_on	0	5.99333	0	1	1	0
E1x50	E2x51	tachykinin_on	0	4.01	1	0	2	1
3x25	E2x51	tachykinin_on	0	4.65667	1	1	2	1
3x29	E2x51	tachykinin_on	0	5.23667	1	1	1	1
4x65	E2x51	tachykinin_on	0	3.52333	1	1	2	1
5x31	5x35	tachykinin_on	0	2.97333	1	0	2	2
3x41	5x461	tachykinin_on	0	2.87667	0	0	2	1
7x30	7x33	tachykinin_on	0	2.04667	6	1	1	2
6x57	E3	tachykinin_on	0	1.82667	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	tachykinin_off	nk1_off
	tachykinin_on	nk1_on nk2_on nk3_on

Network Difference
Value	tachykinin_off	tachykinin_on
I_min	3.6525	3.15667
Number of Linked Nodes	255	256
Number of Specific Nodes	5 (1.96%)	6 (2.34%)
Number of Shared Nodes	250 (98.04%)	250 (97.66%)
Number of Links	287	323
Number of Specific Links	119 (41.46%)	155 (47.99%)
Number of Shared Links	168 (58.54%)	168 (52.01%)
Number of Hubs	35	50
Number of Specific Hubs	12 (34.29%)	27 (54.00%)
Number of Shared Hubs	23 (65.71%)	23 (46.00%)
Average % Shared Neighbours (Jaccard)	43.72
Average % Shared Neighbours (Otsuka)	53.82
Average % Shared Neighbours (Overlap Coefficient)	63.53
Average % Shared Cliques (k3-6)	51.79
Graphlets Similarity	0.638417

Paths Difference
Value	tachykinin_off	tachykinin_on
Number Of Nodes in MetaPath	46	53
Specific Nodes in MetaPath	22 (47.83%)	29 (54.72%)
Shared Nodes in MetaPath	250 (98.04%)	250 (98.04%)
Number Of Links MetaPath	46	59
Specific Links in MetaPath	36 (78.26%)	49 (83.05%)
Shared Links in MetaPath	168 (58.54%)	168 (58.54%)
Number of Shortest Paths	44557	140356
Length Of Smallest Path	3	3
Average Path Length	15.6255	15.2864
Length of Longest Path	34	30
Minimum Path Strength	0.37375	0.511667
Average Path Strength	6.89275	5.81707
Maximum Path Strength	17.2113	17.3317
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.916019	0.910016
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.57143	4.16667
Average % Of Corr. Nodes	38.2344	39.0509
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	35.7276	50.4211
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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