Orange: nodes, hubs and links specific of tsh_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of tsh_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner tsh_on_allo Avg Int. Strength tsh_on Avg Int. Strength tsh_on_allo Num Of Links tsh_on Num Of Links ConSurf
1NT.V39 tsh_on_allo4.613.57333536
2NT.L57 tsh_on_allo3.7654437
3NT.I67 tsh_on_allo4.1554.015625
4NT.I78 tsh_on_allo4.5554.42417
5NT.I81 tsh_on_allo5.096.07667438
6NT.H95 tsh_on_allo8.11257.71435
7NT.F97 tsh_on_allo5.268336.905629
8NT.L100 tsh_on_allo4.35254.805428
9NT.N110 tsh_on_allo5.586.09667436
10NT.L114 tsh_on_allo4.684.82333438
11NT.Y116 tsh_on_allo5.40253.84333433
12NT.L138 tsh_on_allo55.805428
13NT.K146 tsh_on_allo6.6124.68667534
14NT.T159 tsh_on_allo6.2510.1933435
15NT.M164 tsh_on_allo4.886.84537
16NT.L180 tsh_on_allo3.7255.31333437
17NT.L182 tsh_on_allo5.826.53333536
18NT.K183 tsh_on_allo6.77256.28333436
19NT.Y185 tsh_on_allo8.0358.05333437
20NT.F197 tsh_on_allo6.6956.36667439
21NT.T200 tsh_on_allo5.117.37418
22NT.L202 tsh_on_allo5.3027.34528
23NT.V205 tsh_on_allo3.7423.725527
24NT.P228 tsh_on_allo4.9984.85333538
25NT.L230 tsh_on_allo6.0626.09333534
26NT.V233 tsh_on_allo3.093.095427
27NT.S234 tsh_on_allo4.34755.31667439
28NT.R255 tsh_on_allo4.842510.91424
29NT.P264 tsh_on_allo4.474.105529
30NT.F269 tsh_on_allo4.5458.23437
31NT.R274 tsh_on_allo9.1356.51333433
32NT.Y279 tsh_on_allo7.4686.26333539
33NT.F405 tsh_on_allo7.72257.82438
341x32 tsh_on_allo5.86255.22333434
351x39 tsh_on_allo4.31754.43429
361x56 tsh_on_allo5.8357.72333438
372x38 tsh_on_allo4.0563.3539
382x41 tsh_on_allo5.4786.06529
392x46 tsh_on_allo5.948335.25667639
402x53 tsh_on_allo5.3784.93539
412x56 tsh_on_allo6.0346.06667539
422x57 tsh_on_allo3.7343.4529
43E1.Y482 tsh_on_allo5.29257.56667438
44E1.I486 tsh_on_allo6.622.31428
453x33 tsh_on_allo3.7864.92529
463x38 tsh_on_allo5.67255.59667439
474x46 tsh_on_allo4.8347.41539
484x50 tsh_on_allo6.4846.59539
49E2x51 tsh_on_allo6.0744.93539
50E2.M572 tsh_on_allo7.372.88419
515x43 tsh_on_allo5.10253.18667437
526x44 tsh_on_allo5.28755.085428
536x59 tsh_on_allo2.5841.505526
547x37 tsh_on_allo5.16755.2429
557x42 tsh_on_allo4.693.405429
567x53 tsh_on_allo4.971437.21667739
578x54 tsh_on_allo3.153.32667435
58Allo1 tsh_on_allo6.9671401400
59NT.L50 Shared4.521673.59645
60NT.P51 Shared3.47754.815445
61NT.I60 Shared4.4155.2575444
62NT.H70 Shared4.6255.2725444
63NT.F72 Shared4.621675.3675649
64NT.Y82 Shared10.23759.788454
65NT.Q91 Shared6.234.2125443
66NT.Y98 Shared8.1856.725442
67NT.H105 Shared9.042511.706457
68NT.R109 Shared13.5410.54445
69NT.D118 Shared6.6186.61545
70NT.F130 Shared6.8286.938556
71NT.F134 Shared7.95511.0675645
72NT.T136 Shared5.318334.08667669
73NT.F141 Shared5.951676.84647
74NT.F154 Shared5.936.034656
75NT.L156 Shared4.37254.932457
76NT.E157 Shared8.128.04548
77NT.N161 Shared5.7057.3825448
78NT.F172 Shared5.998335.65833668
79NT.L175 Shared6.7526.38547
80NT.N187 Shared6.5127.38549
81NT.F189 Shared8.4749.422558
82NT.N198 Shared6.07254.664457
83NT.Y206 Shared4.8044.975546
84NT.N208 Shared6.8167.025545
85NT.K209 Shared5.98255.852457
86NT.F221 Shared6.82755.172459
87NT.D232 Shared10.47759.495449
88NT.L241 Shared3.7863.37549
89NT.L246 Shared4.26755.3625447
90NT.I253 Shared6.7787.9175544
91NT.F286 Shared4.566675.306658
92NT.E409 Shared8.236.2875449
93NT.I411 Shared4.3925.22558
941x47 Shared3.152.28447
951x53 Shared3.9543.3275549
961x57 Shared4.06254.96448
972x40 Shared5.614.90667469
982x50 Shared6.3785.575549
99E1.Y481 Shared5.536675.88648
100E1x50 Shared6.3667.385549
1013x32 Shared4.455.235549
1023x37 Shared6.0124.7925548
1033x42 Shared3.7254.815449
1043x51 Shared5.174.84447
105E2.Y563 Shared9.0268.432559
106E2.I568 Shared5.074.946459
1075x39 Shared5.351676.7425649
1085x51 Shared7.8754.4725448
1095x58 Shared6.726676.16649
1106x54 Shared7.94757.98448
1117x41 Shared5.631675.2075649
1127x49 Shared7.9656.895449
1138x50 Shared5.586675.706659
114Lig Shared62.152978.992521400
115NT.H32 tsh_on3.714.405145
116NT.R38 tsh_on7.196675.06344
117NT.T40 tsh_on6.555.1248
118NT.I44 tsh_on4.513334.285345
119NT.P48 tsh_on3.3353.33249
120NT.K58 tsh_on6.647.7175345
121NT.L59 tsh_on3.173.685146
122NT.T62 tsh_on10.26675.8875347
123NT.L64 tsh_on7.736675.34346
124NT.R80 tsh_on6.467.59833364
125NT.D86 tsh_on14.455.9525148
126NT.E107 tsh_on11.90337.3825346
127NT.L125 tsh_on3.763.6025348
128NT.P142 tsh_on5.2856.2275249
129NT.I158 tsh_on4.563334.394357
130NT.D160 tsh_on4.597.3525348
131NT.L231 tsh_on3.406673.095347
132NT.V238 tsh_on4.184.2875347
133NT.P242 tsh_on6.74.6225249
134NT.D276 tsh_on9.167.112354
135NT.T399 tsh_on3.523333.06344
1361x35 tsh_on5.596675.48349
1371x40 tsh_on4.825.1275349
1381x52 tsh_on5.9154.2475247
1392x45 tsh_on7.506677.4775348
1402x63 tsh_on7.054.61248
1413x41 tsh_on6.9655.2275247
142E2x52 tsh_on6.766674.635349
143E2.D573 tsh_on7.386676.7425348
1445x40 tsh_on3.932.572357
1457x34 tsh_on4.723333.9225349
1467x38 tsh_on4.663.865349
   
Orange: nodes, hubs and links specific of tsh_on_allo network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of tsh_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner tsh_on_allo Recurrence tsh_on Recurrence tsh_on_allo Hub1? tsh_on Hub1? tsh_on_allo Hub2? tsh_on Hub2? ConSurf1 ConSurf2
1NT.L100 NT.L125 tsh_on_allo25.91450YesNoNoYes88
2NT.L125 NT.V147 tsh_on_allo41.73760NoYesNoNo87
3NT.L175 NT.V147 tsh_on_allo42.14470YesYesNoNo77
4NT.C176 NT.F154 tsh_on_allo53.40950.276001NoNoYesYes66
5NT.C176 NT.E178 tsh_on_allo53.08450NoNoNoNo65
6NT.E178 NT.I152 tsh_on_allo51.03766.45807NoNoNoNo53
7NT.F153 NT.I152 tsh_on_allo50.62690NoNoNoNo53
8Lig NT.F153 tsh_on_allo50.21141.38074YesYesNoNo05
9NT.A121 NT.S96 tsh_on_allo33.75250NoNoNoNo97
10NT.A121 NT.D118 tsh_on_allo32.76720NoNoYesYes95
11NT.F97 NT.S96 tsh_on_allo27.87180YesNoNoNo97
12NT.F97 NT.L122 tsh_on_allo15.05120YesNoNoNo97
13NT.L138 NT.M164 tsh_on_allo11.00420YesNoYesNo87
14NT.L156 NT.L175 tsh_on_allo19.32050YesYesYesYes77
15NT.L156 NT.L182 tsh_on_allo44.37260.143393YesYesYesNo76
16NT.L175 NT.L180 tsh_on_allo19.86560.255411YesYesYesNo77
17NT.L180 NT.L182 tsh_on_allo44.17720.303944YesNoYesNo76
18Lig NT.T179 tsh_on_allo11.40050YesYesNoNo05
19NT.K201 NT.T179 tsh_on_allo11.01860NoNoNoNo45
20NT.K201 NT.Y225 tsh_on_allo10.11034.62264NoNoNoNo44
21NT.L182 NT.V205 tsh_on_allo86.73440YesNoYesNo67
22NT.F189 NT.N210 tsh_on_allo10.88220.0757409YesYesNoNo89
23NT.L231 NT.V205 tsh_on_allo88.30870.74981NoYesYesNo77
24NT.L213 NT.N210 tsh_on_allo13.77171.7668NoNoNoNo99
25NT.L213 NT.T236 tsh_on_allo13.83410.0774567NoNoNoNo99
26NT.L231 NT.V233 tsh_on_allo89.65390.441944NoYesYesNo77
27NT.T236 NT.V238 tsh_on_allo14.06610.101233NoNoNoYes97
28NT.L241 NT.V233 tsh_on_allo89.54230YesYesYesNo97
29NT.L241 NT.P264 tsh_on_allo53.92621.995YesYesYesNo99
30NT.L263 NT.P264 tsh_on_allo51.50751.79768NoNoYesNo89
31NT.H282 NT.L263 tsh_on_allo50.51411.39986NoNoNoNo98
32NT.H282 NT.Y279 tsh_on_allo1001.20278NoNoYesNo99
33NT.L241 NT.L252 tsh_on_allo49.92920.334583YesYesNoNo99
34NT.L252 NT.L277 tsh_on_allo49.88130NoNoNoNo99
35NT.H282 NT.L277 tsh_on_allo49.67740.0014707NoNoNoNo99
36E1.I486 NT.Y279 tsh_on_allo98.42590YesNoYesNo89
37E1.A485 NT.I281 tsh_on_allo98.19030NoNoNoNo99
38E1.I486 NT.I281 tsh_on_allo98.3850YesNoNoNo89
39E1.A485 E1.Y481 tsh_on_allo97.99521.69204NoNoYesYes98
40E1.Y481 E2.S567 tsh_on_allo20.92112.35875YesYesNoNo89
417x34 E2.S567 tsh_on_allo20.77122.15751NoYesNoNo99
427x34 E2.I568 tsh_on_allo18.25853.02547NoYesYesYes99
43Allo1 E2x51 tsh_on_allo12.98020YesNoYesNo09
44E1.Y481 NT.I411 tsh_on_allo73.60955.0967YesYesYesYes88
452x56 2x60 tsh_on_allo69.45380YesNoNoNo98
462x53 2x56 tsh_on_allo55.90130YesNoYesNo99
471x50 2x47 tsh_on_allo10.49760NoNoNoNo99
481x50 2x50 tsh_on_allo11.53870.710591NoNoYesYes99
492x46 2x50 tsh_on_allo28.57240YesNoYesYes99
502x46 7x53 tsh_on_allo12.97930YesNoYesNo99
512x56 3x32 tsh_on_allo11.29451.13562YesNoYesYes99
523x47 5x57 tsh_on_allo13.39977.36598NoNoNoNo99
533x47 5x58 tsh_on_allo14.00378.6798NoNoYesYes99
545x58 7x53 tsh_on_allo20.56120YesYesYesNo99
553x51 5x57 tsh_on_allo10.06665.38054YesYesNoNo79
56NT.L241 NT.V238 tsh_on_allo14.06160YesYesNoYes97
57NT.F97 NT.L100 tsh_on_allo15.03250YesNoYesNo98
58NT.L122 NT.L125 tsh_on_allo15.43310.276001NoNoNoYes78
59NT.F154 NT.L156 tsh_on_allo24.74530YesYesYesYes67
60NT.F154 NT.L180 tsh_on_allo26.94610.0622595YesYesYesNo67
61NT.D118 NT.Y116 Shared13.948413.3843YesYesYesNo53
62NT.Q91 NT.Y116 Shared11.982716.9307YesYesYesNo33
63E2.I568 E2x51 Shared14.456373.0306YesYesYesNo99
642x60 NT.I411 Shared69.658784.5562NoNoYesYes88
652x50 7x46 Shared57.37562.6007YesYesNoNo99
662x53 7x46 Shared57.929163.3348YesNoNoNo99
672x50 7x49 Shared18.263638.9411YesYesYesYes99
687x49 7x53 Shared12.172914.1746YesYesYesNo99
69Lig NT.P162 tsh_on078.6786YesYesNoNo07
70NT.P162 NT.Y163 tsh_on0.980879.0602NoNoNoNo74
71NT.G137 NT.Y163 tsh_on079.4321NoNoNoNo84
72NT.G137 NT.T136 tsh_on0.51605779.8034NoNoYesYes89
73Lig NT.K58 tsh_on018.9923YesYesNoYes05
74NT.K58 NT.T40 tsh_on1.3825318.6291NoYesNoYes58
75Lig NT.I60 tsh_on5.4144319.4343YesYesYesYes04
76NT.I60 NT.T40 tsh_on018.5908YesYesNoYes48
77NT.K42 NT.T40 tsh_on033.7459NoNoNoYes28
78NT.D43 NT.K42 tsh_on032.8669NoNoNoNo42
79NT.D43 NT.H63 tsh_on1.0008331.9874NoNoNoNo44
80NT.H63 NT.T88 tsh_on3.0015930.227NoNoNoNo44
81NT.R65 NT.T88 tsh_on5.9993629.346NoNoNoNo44
82NT.Q90 NT.R65 tsh_on6.9977128.4646NoNoNoNo44
83NT.Q90 NT.Q91 tsh_on8.9930726.7002NoNoYesYes43
84NT.I133 NT.T136 tsh_on0.56061842.0183NoNoYesYes89
85NT.I133 NT.P142 tsh_on042.1617NoNoNoYes89
86NT.F154 NT.L175 tsh_on3.3724910.9552YesYesYesYes67
87NT.F154 NT.L128 tsh_on0.92386110.0373YesYesNoNo69
88NT.N161 NT.T136 tsh_on1.9251443.5397YesYesYesYes89
89NT.I158 NT.N161 tsh_on041.5337NoYesYesYes78
90NT.I158 NT.L156 tsh_on042.0384NoYesYesYes77
91NT.F141 NT.P142 tsh_on0.46204341.545YesYesNoYes79
92NT.F141 NT.F172 tsh_on5.2859243.7895YesYesYesYes78
93NT.F172 NT.L156 tsh_on042.3752YesYesYesYes87
94NT.F172 NT.F197 tsh_on0.87457398.016YesYesYesNo89
95NT.F197 NT.F221 tsh_on0.5291198.2322YesNoYesYes99
96NT.F221 NT.P228 tsh_on0.7253649.1823YesYesYesNo98
97NT.L249 NT.P228 tsh_on049.0676NoNoYesNo88
98NT.F269 NT.L249 tsh_on0100YesNoNoNo78
99NT.F221 NT.L246 tsh_on0.39497649.4328YesYesYesYes97
100NT.L246 NT.L249 tsh_on1.2587551.1275YesYesNoNo78
101NT.F269 NT.F286 tsh_on1.7862896.8762YesNoYesYes78
1022x67 NT.I411 tsh_on093.4066NoNoYesYes98
1032x67 E1.H484 tsh_on0.70960693.7802NoNoNoNo96
104E1.E480 E1.H484 tsh_on0.35514193.9662NoNoNoNo66
105E1.E480 E1.N483 tsh_on094.3368NoNoNoNo68
106E1.N483 E1.Y482 tsh_on0.9607794.7055NoNoYesNo88
107E1.Y482 NT.A285 tsh_on1.9071495.2548YesNoNoNo88
108NT.A285 NT.F286 tsh_on2.2591395.4369NoNoYesYes88
1092x60 E2.I568 tsh_on084.3545NoNoYesYes89
1101x53 8x50 tsh_on3.8493812.7164YesYesYesYes99
1111x53 1x57 tsh_on3.2662615.23YesYesYesYes98
1121x57 2x40 tsh_on2.4731617.7481YesYesYesYes89
1132x40 I1x50 tsh_on0.74156428.2651YesYesNoNo96
1142x41 I1x50 tsh_on1.1059328.8813YesNoNoNo96
1152x41 2x45 tsh_on0.3533429.498YesNoNoYes98
1162x45 3x42 tsh_on032.4619NoYesYesYes89
1172x46 3x42 tsh_on9.0909746.1443YesNoYesYes99
1182x46 3x39 tsh_on022.6651YesNoNoNo99
1192x50 3x39 tsh_on0.36234222.9478YesYesNoNo99
1202x53 3x32 tsh_on063.4299YesNoYesYes99
1213x32 E2x51 tsh_on0.50637964.03YesYesYesNo99
1222x46 7x49 tsh_on0.10555224.117YesNoYesYes99
123E2x51 E2x52 tsh_on013.5074YesNoNoYes99
1243x50 5x58 tsh_on0.0078770111.93NoNoYesYes99
1253x50 7x53 tsh_on0.66369412.2509NoNoYesNo99
126NT.F172 NT.L175 tsh_on010.8812YesYesYesYes87

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
LigNT.M300tsh_on13.6801101
LigNT.D386Shared5.975.431101
LigNT.L296tsh_on14.6101101
LigNT.I85Shared4.512.941101
LigNT.V87tsh_on3.1701101
LigNT.N110Shared5.615.391101
LigNT.N135tsh_on12.8301101
LigNT.P162tsh_on3.2801101
LigNT.D160tsh_on7.0701101
LigNT.I152tsh_on13.9601101
LigNT.F153Shared10.5637.21101
LigNT.R80tsh_on6.201101
LigNT.Y82tsh_on10.201101
LigNT.H105tsh_on11.7301101
LigNT.F130tsh_on7.2201101
LigNT.I155tsh_on4.8401101
LigNT.R109Shared9.9713.351101
LigNT.E157tsh_on5.401101
LigNT.F381tsh_on8.5301101
LigNT.Y385tsh_on5.1401101
LigNT.E297tsh_on12.5501101
LigNT.I389tsh_on4.4701101
LigNT.E251Shared5.8415.041101
LigNT.D203Shared11.0620.741101
LigNT.A204Shared6.4241101
LigNT.S229Shared3.062.541101
LigNT.L230Shared5.6411.721101
LigNT.I253tsh_on6.0401101
LigNT.R274tsh_on3.0901101
LigNT.D276tsh_on3.4501101
LigNT.K209Shared8.4110.031101
LigNT.K58tsh_on9.4501101
LigNT.E107tsh_on3.8101101
LigNT.I60Shared5.898.831101
LigNT.E61tsh_on6.7601101
NT.E34NT.H32tsh_on6.1501022
NT.H32NT.R38tsh_on3.3901021
NT.H32NT.T40tsh_on6.8501022
NT.E34NT.R38tsh_on9.301021
NT.R38NT.T56Shared5.176.471112
NT.K42NT.T40tsh_on300012
NT.K58NT.T40Shared7.516.011012
NT.I60NT.T40tsh_on3.0401112
NT.R80NT.T56Shared6.477.761112
NT.I60NT.K58Shared4.364.361111
NT.K58NT.Y82Shared9.559.551011
NT.I60NT.S84Shared7.743.11111
NT.E61NT.I85tsh_on5.4701011
NT.R80NT.S79tsh_on5.2701112
NT.R80NT.Y82Shared9.268.231111
NT.H105NT.R80Shared15.83.391111
NT.H105NT.Y82Shared8.7113.071111
NT.E107NT.Y82Shared11.2210.11111
NT.I85NT.S84tsh_on6.1901111
NT.E107NT.H105tsh_on9.8501111
NT.F130NT.H105Shared12.4416.971111
NT.E107NT.R109Shared4.6518.611111
NT.N110NT.R109Shared7.237.231111
NT.F134NT.R109Shared20.3114.970121
NT.N110NT.N135Shared5.455.451111
NT.F130NT.G132Shared3.013.011112
NT.F130NT.I155Shared5.026.281111
NT.E157NT.F130Shared74.661111
NT.F134NT.G132Shared4.524.520122
NT.E157NT.F134Shared11.6612.831112
NT.F134NT.T159Shared7.785.190122
NT.D160NT.N135Shared5.394.041011
NT.D151NT.F153tsh_on3.5800021
NT.E178NT.I152Shared6.839.560021
NT.E157NT.K183Shared8.112.151112
NT.D160NT.T159Shared11.564.341012
NT.T159NT.Y185Shared11.2411.240122
NT.D160NT.N186Shared5.395.391012
NT.P162NT.Y163Shared6.956.951012
NT.D203NT.T179Shared4.3414.451111
NT.K183NT.Y185Shared4.788.360122
NT.K183NT.Y206Shared5.973.580122
NT.N208NT.Y185Shared8.145.811122
NT.K209NT.N186Shared5.64.21112
NT.N208NT.Y206Shared3.493.491122
NT.L230NT.Y206Shared4.695.861112
NT.D232NT.Y206Shared5.755.751122
NT.K209NT.N208Shared8.396.991112
NT.D232NT.N208Shared8.0814.811122
NT.K209NT.Q235Shared5.422.711112
NT.E251NT.L230Shared7.955.31111
NT.D232NT.S234Shared7.367.361122
NT.D232NT.I253Shared16.7913.991121
NT.I253NT.S234Shared4.643.11112
NT.R255NT.S234Shared3.953.950122
NT.E251NT.R274Shared9.312.791111
NT.D276NT.I253tsh_on4.201111
NT.D276NT.R255Shared17.875.961112
NT.D276NT.R274Shared7.1514.291111
NT.E297NT.R293tsh_on4.6501012
NT.C390NT.R293tsh_on5.5700022
NT.L296NT.M300tsh_on7.0701011
NT.H384NT.S383tsh_on4.1800021
NT.G391NT.Y387tsh_on5.7900021
NT.D392NT.Y387tsh_on3.4500021
NT.C390NT.I389tsh_on3.2700021
NT.D203NT.T181Shared2.894.341112
NT.D276NT.T399Shared2.897.231112
NT.D43NT.K42tsh_on2.7700021
NT.E178NT.K201tsh_on2.700022
NT.R112NT.V87Shared2.622.620021
NT.R80NT.T104tsh_on2.5901112
NT.D36NT.R38tsh_on2.3800021
LigNT.T388tsh_on1.6801101
NT.K250NT.S229tsh_on1.5300021
LigNT.G294tsh_on1.5101101
NT.K209NT.K211tsh_on1.4401112
LigNT.D382Shared1.391.361101
NT.E35NT.R38tsh_on_allo04.650021
LigNT.R38tsh_on_allo010.471101
LigNT.K42tsh_on_allo04.781101
NT.S79NT.T104tsh_on_allo06.40022
LigNT.S84tsh_on_allo04.641101
NT.I85NT.N110tsh_on_allo04.251111
NT.E107NT.F134tsh_on_allo071112
NT.F130NT.F134tsh_on_allo03.221112
NT.F153NT.I152tsh_on_allo05.021111
NT.I155NT.T181tsh_on_allo04.561012
NT.E157NT.T159tsh_on_allo04.231112
NT.E157NT.Y185tsh_on_allo06.731112
NT.K201NT.T179tsh_on_allo030021
LigNT.T179tsh_on_allo04.51101
NT.K183NT.T181tsh_on_allo030122
NT.A204NT.Y206tsh_on_allo05.340112
NT.A204NT.L230tsh_on_allo03.150111
NT.N208NT.S234tsh_on_allo02.981122
NT.I253NT.L230tsh_on_allo04.281111
NT.I253NT.R255tsh_on_allo06.261112
NT.I253NT.R274tsh_on_allo06.261111
NT.R255NT.R274tsh_on_allo03.20121
LigNT.S383tsh_on_allo07.641101
NT.D386NT.Y385tsh_on_allo04.60111
NT.I389NT.Y385tsh_on_allo08.461011
LigNT.Y387tsh_on_allo029.911101
NT.H105NT.T104tsh_on_allo02.741112
NT.D36NT.E35tsh_on_allo02.60022
NT.C390NT.G391tsh_on_allo01.960022
NT.G391NT.I389tsh_on_allo01.760021
NT.N161NT.P162tsh_on_allo01.632021
NT.T88NT.V87tsh_on_allo01.590021
NT.K211NT.N186tsh_on_allo01.40022
NT.E61NT.I60tsh_on_allo01.371011

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
tsh_on_allo 7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
tsh_on 7T9I-TSH-TSH-Gs/&β;1/&γ;2
Network Difference
Value tsh_on_allo tsh_on
Imin 2.94 2.9
Number of Linked Nodes 539 564
Number of Specific Nodes 22 (4.08%) 47  (8.33%)
Number of Shared Nodes 517 (95.92%) 517  (91.67%)
Number of Links 686 654
Number of Specific Links 255 (37.17%) 223  (34.10%)
Number of Shared Links 431 (62.83%) 431  (65.90%)
Number of Hubs 114 88
Number of Specific Hubs 58 (50.88%) 32  (36.36%)
Number of Shared Hubs 56 (49.12%) 56  (63.64%)
Average % Shared Neighbours (Jaccard) 47.93
Average % Shared Neighbours (Otsuka) 57.57
Average % Shared Neighbours (Overlap Coefficient) 67.67
Average % Shared Cliques (k3-6) 53.69
Graphlets Similarity 0.660873
Paths Difference
Value tsh_on_allo tsh_on
Number Of Nodes in MetaPath 65 63
Specific Nodes in MetaPath 46 (70.77%) 44  (69.84%)
Shared Nodes in MetaPath 517 (95.92%) 517  (95.92%)
Number Of Links MetaPath 68 66
Specific Links in MetaPath 60 (88.24%) 58  (87.88%)
Shared Links in MetaPath 431 (62.83%) 431  (62.83%)
Number of Shortest Paths 616782 528380
Length Of Smallest Path 3 3
Average Path Length 26.2761 31.7356
Length of Longest Path 52 61
Minimum Path Strength 1.355 1.31
Average Path Strength 5.75672 5.24948
Maximum Path Strength 24.0433 16.085
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.97684 0.977194
Maximum Path Correlation 1 1
Minimum % Of Corr. Nodes 2.94118 3.0303
Average % Of Corr. Nodes 55.5806 50.9339
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 51.4139 38.4666
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

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