psnGPCR

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Orange: nodes, hubs and links specific of vasop-oxy_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasop-oxy_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	vasop-oxy_off Int. Strength	vasop-oxy_on Int. Strength	vasop-oxy_off Hub1?	vasop-oxy_on Hub1?	vasop-oxy_off Hub2?	vasop-oxy_on Hub2?	ConSurf1	ConSurf2
1	3x29	Lig	vasop-oxy_off	9.73	0	Yes	Yes	Yes	Yes	4	0
2	4x61	Lig	vasop-oxy_off	5.1	0	Yes	No	Yes	Yes	6	0
3	4x65	Lig	vasop-oxy_off	5.6	0	Yes	Yes	Yes	Yes	6	0
4	6x48	Lig	vasop-oxy_off	7.86	0	Yes	Yes	Yes	Yes	8	0
5	1x29	1x33	vasop-oxy_off	6.98	0	No	No	No	No	5	5
6	1x42	7x43	vasop-oxy_off	4.28	0	No	No	No	No	7	5
7	1x43	2x57	vasop-oxy_off	5.96	0	No	No	No	No	6	7
8	1x45	7x51	vasop-oxy_off	14.81	0	No	No	No	No	5	6
9	1x50	2x47	vasop-oxy_off	5.96	0	No	No	No	No	9	9
10	1x53	7x53	vasop-oxy_off	6.31	0	No	No	Yes	No	9	9
11	1x56	8x50	vasop-oxy_off	4.73	0	No	No	No	No	7	8
12	2x38	I1x51	vasop-oxy_off	10.16	0	Yes	No	Yes	No	7	7
13	3x49	I1x51	vasop-oxy_off	15.13	0	No	No	Yes	No	9	7
14	3x50	I1x51	vasop-oxy_off	6.77	0	Yes	No	Yes	No	9	7
15	3x53	I1x51	vasop-oxy_off	4.39	0	No	No	Yes	No	8	7
16	I1x51	I2	vasop-oxy_off	9.32	0	Yes	No	Yes	No	7	7
17	2x38	2x42	vasop-oxy_off	4.28	0	Yes	No	Yes	Yes	7	8
18	2x38	4x39	vasop-oxy_off	7.46	0	Yes	No	No	No	7	4
19	2x39	3x50	vasop-oxy_off	9.72	0	No	No	Yes	No	8	9
20	2x39	6x33	vasop-oxy_off	4.42	0	No	No	No	No	8	8
21	2x41	2x42	vasop-oxy_off	4.29	0	Yes	No	Yes	Yes	5	8
22	2x41	2x45	vasop-oxy_off	13.58	0	Yes	No	No	No	5	9
23	2x41	4x46	vasop-oxy_off	5.24	0	Yes	No	No	No	5	7
24	2x43	7x53	vasop-oxy_off	16.76	0	No	No	Yes	No	7	9
25	2x45	4x50	vasop-oxy_off	5.29	0	No	No	Yes	Yes	9	9
26	2x56	2x60	vasop-oxy_off	5.12	0	Yes	Yes	No	Yes	7	7
27	2x56	3x32	vasop-oxy_off	11.52	0	Yes	Yes	No	No	7	7
28	2x60	7x38	vasop-oxy_off	6.8	0	No	Yes	No	No	7	6
29	2x63	2x64	vasop-oxy_off	5.58	0	No	Yes	No	No	5	5
30	2x63	2x67	vasop-oxy_off	8.02	0	No	Yes	No	No	5	4
31	E1x49	E1x51	vasop-oxy_off	23.66	0	No	No	No	No	5	3
32	E1x50	E1x52	vasop-oxy_off	4.52	0	Yes	Yes	No	No	7	6
33	3x22	3x26	vasop-oxy_off	16.68	0	No	No	No	No	4	6
34	3x25	E2	vasop-oxy_off	4.76	0	No	No	Yes	Yes	9	4
35	3x26	4x62	vasop-oxy_off	5.23	0	No	No	No	No	6	5
36	3x33	5x43	vasop-oxy_off	5.71	0	Yes	Yes	No	Yes	5	5
37	3x34	4x54	vasop-oxy_off	4.47	0	No	No	No	No	6	3
38	3x36	6x48	vasop-oxy_off	5.82	0	No	No	Yes	Yes	6	8
39	3x41	3x44	vasop-oxy_off	4.69	0	No	No	Yes	No	6	7
40	3x43	6x40	vasop-oxy_off	4.28	0	No	No	Yes	No	8	8
41	3x43	6x41	vasop-oxy_off	4.47	0	No	No	Yes	No	8	8
42	3x44	5x50	vasop-oxy_off	6.57	0	Yes	No	No	No	7	9
43	3x44	5x54	vasop-oxy_off	5.54	0	Yes	No	No	No	7	8
44	3x46	6x37	vasop-oxy_off	4.52	0	No	No	No	No	8	8
45	3x47	5x58	vasop-oxy_off	6.36	0	No	No	Yes	No	8	9
46	3x49	3x50	vasop-oxy_off	7.15	0	No	No	Yes	No	9	9
47	3x50	6x33	vasop-oxy_off	7.76	0	Yes	No	No	No	9	8
48	3x50	6x34	vasop-oxy_off	5.23	0	Yes	No	No	No	9	7
49	3x50	6x37	vasop-oxy_off	9.06	0	Yes	No	No	No	9	8
50	3x52	I2	vasop-oxy_off	5.54	0	No	Yes	Yes	No	3	7
51	3x54	5x61	vasop-oxy_off	10.3	0	Yes	No	No	No	8	8
52	3x54	6x30	vasop-oxy_off	5.82	0	Yes	No	No	No	8	8
53	3x56	I2	vasop-oxy_off	13.26	0	No	No	Yes	No	5	7
54	4x61	4x64	vasop-oxy_off	5.49	0	Yes	No	Yes	No	6	5
55	4x64	5x39	vasop-oxy_off	12.09	0	Yes	No	Yes	Yes	5	7
56	5x34	5x35	vasop-oxy_off	5.63	0	No	No	No	No	2	4
57	5x41	6x56	vasop-oxy_off	6.02	0	No	No	No	No	5	6
58	5x45	5x48	vasop-oxy_off	7.14	0	No	No	No	No	5	5
59	5x47	5x51	vasop-oxy_off	10.09	0	No	No	No	No	8	6
60	5x47	6x49	vasop-oxy_off	9.99	0	No	No	No	No	8	6
61	5x54	6x41	vasop-oxy_off	11.92	0	No	No	Yes	No	8	8
62	5x58	6x38	vasop-oxy_off	13.41	0	Yes	No	No	No	9	6
63	5x58	6x41	vasop-oxy_off	6.31	0	Yes	No	Yes	No	9	8
64	5x64	6x25	vasop-oxy_off	14.1	0	No	No	No	No	6	3
65	6x35	7x56	vasop-oxy_off	4.96	0	No	No	Yes	No	8	7
66	6x36	8x47	vasop-oxy_off	5.78	0	No	No	No	No	8	8
67	6x39	7x56	vasop-oxy_off	6.28	0	No	No	Yes	No	7	7
68	6x40	7x49	vasop-oxy_off	5.82	0	Yes	No	No	Yes	8	9
69	6x40	7x52	vasop-oxy_off	4.42	0	Yes	No	No	No	8	8
70	6x48	7x41	vasop-oxy_off	7.78	0	Yes	Yes	No	No	8	7
71	7x29	7x32	vasop-oxy_off	10.71	0	No	No	No	No	4	2
72	7x35	7x39	vasop-oxy_off	4.28	0	No	No	No	No	4	5
73	8x48	8x51	vasop-oxy_off	9.03	0	No	No	No	No	5	8
74	2x46	3x46	vasop-oxy_off	4.24	0	No	No	No	No	9	8
75	3x37	4x53	vasop-oxy_off	4.19	0	Yes	Yes	No	No	6	8
76	1x43	1x47	vasop-oxy_off	4.15	0	No	No	No	No	6	6
77	1x47	2x51	vasop-oxy_off	4.15	0	No	No	No	No	6	7
78	3x27	3x31	vasop-oxy_off	4.15	0	No	No	No	No	5	5
79	1x49	7x50	vasop-oxy_off	4.06	0	No	No	No	No	8	9
80	1x35	1x39	vasop-oxy_off	3.98	0	No	Yes	No	No	5	6
81	1x49	1x52	vasop-oxy_off	3.92	0	No	No	No	No	8	6
82	1x48	1x49	vasop-oxy_off	3.71	0	No	No	No	No	4	8
83	7x55	7x56	vasop-oxy_off	3.65	0	No	No	Yes	No	5	7
84	6x50	7x37	vasop-oxy_off	3.53	0	No	No	No	No	9	5
85	6x55	7x34	vasop-oxy_off	3.51	0	No	No	Yes	Yes	6	4
86	6x30	I2	vasop-oxy_off	3.35	0	No	No	Yes	No	8	7
87	6x50	7x40	vasop-oxy_off	3.28	0	No	No	No	No	9	7
88	7x48	7x52	vasop-oxy_off	3.27	0	No	No	No	No	6	8
89	4x39	4x43	vasop-oxy_off	3.2	0	No	No	No	No	4	3
90	3x45	4x45	vasop-oxy_off	3.15	0	No	No	No	No	7	5
91	1x38	1x42	vasop-oxy_off	3.07	0	No	No	No	No	4	7
92	5x44	5x48	vasop-oxy_off	3.04	0	No	No	No	No	5	5
93	1x53	1x57	vasop-oxy_off	2.98	0	No	No	Yes	No	9	7
94	6x26	6x31	vasop-oxy_off	2.94	0	No	No	No	No	6	6
95	3x54	5x64	vasop-oxy_off	2.91	0	Yes	No	No	No	8	6
96	1x39	7x38	vasop-oxy_off	2.83	0	No	No	No	No	6	6
97	2x41	4x42	vasop-oxy_off	2.77	0	Yes	No	No	No	5	7
98	2x42	4x42	vasop-oxy_off	2.77	0	Yes	Yes	No	No	8	7
99	5x67	5x68	vasop-oxy_off	2.64	0	No	No	No	No	5	7
100	4x38	4x41	vasop-oxy_off	2.59	0	No	No	No	No	4	7
101	6x38	6x42	vasop-oxy_off	2.44	0	No	No	No	No	6	5
102	3x23	3x26	vasop-oxy_off	2.43	0	No	No	No	No	3	6
103	4x38	4x40	vasop-oxy_off	2.13	0	No	No	No	No	4	5
104	3x35	3x38	vasop-oxy_off	1.95	0	No	No	No	No	6	7
105	4x59	4x60	vasop-oxy_off	1.87	0	No	No	No	No	4	7
106	2x54	7x46	vasop-oxy_off	1.81	0	No	No	No	No	7	9
107	6x46	6x47	vasop-oxy_off	1.71	0	No	No	No	No	6	8
108	1x34	1x38	vasop-oxy_off	1.6	0	No	No	No	No	5	4
109	7x30	E3	vasop-oxy_off	1.57	0	No	No	Yes	Yes	4	4
110	6x41	6x45	vasop-oxy_off	1.54	0	Yes	No	No	No	8	6
111	6x45	6x46	vasop-oxy_off	1.54	0	No	No	No	No	6	6
112	2x65	2x66	vasop-oxy_off	1.52	0	No	No	No	No	5	6
113	3x28	3x29	vasop-oxy_off	1.52	0	No	No	Yes	Yes	6	4
114	3x54	6x31	vasop-oxy_off	1.47	0	Yes	No	No	No	8	6
115	4x41	I2	vasop-oxy_off	1.47	0	No	No	Yes	No	7	7
116	6x28	6x31	vasop-oxy_off	1.45	0	No	No	No	No	6	6
117	7x33	7x34	vasop-oxy_off	1.39	0	No	No	Yes	Yes	5	4
118	1x41	1x44	vasop-oxy_off	1.38	0	No	No	No	No	4	4
119	1x57	8x50	vasop-oxy_off	1.38	0	Yes	No	No	No	7	8
120	4x47	4x51	vasop-oxy_off	1.38	0	No	No	No	No	3	4
121	1x58	2x44	vasop-oxy_off	1.31	0	No	No	No	No	2	6
122	2x52	2x551	vasop-oxy_off	1.31	0	No	No	No	No	6	5
123	7x54	8x51	vasop-oxy_off	1.24	0	No	No	No	No	7	8
124	7x53	7x54	vasop-oxy_off	1.2	0	Yes	No	No	No	9	7
125	2x56	Lig	Shared	30.6	12.4	Yes	Yes	Yes	Yes	7	0
126	3x32	Lig	Shared	16.32	4.51	No	No	Yes	Yes	7	0
127	3x36	Lig	Shared	8.67	6.08	No	No	Yes	Yes	6	0
128	5x40	Lig	Shared	5.47	7.98	No	No	Yes	Yes	5	0
129	6x51	Lig	Shared	9.33	7.38	No	Yes	Yes	Yes	7	0
130	6x55	Lig	Shared	10.2	20.81	No	No	Yes	Yes	6	0
131	1x28	1x31	Shared	9.61	5.43	No	Yes	No	Yes	5	5
132	1x35	2x64	Shared	12.99	6.75	No	Yes	No	No	5	5
133	1x40	2x61	Shared	4.76	4.5	No	No	No	No	4	7
134	1x42	7x47	Shared	6.55	1.71	No	No	No	No	7	7
135	1x45	7x47	Shared	6.35	1.81	No	No	No	No	5	7
136	1x50	7x50	Shared	11.4	8.15	No	No	No	No	9	9
137	1x53	2x47	Shared	4.85	3.42	No	No	No	No	9	9
138	1x54	2x48	Shared	4.28	1.38	No	No	No	No	7	6
139	2x37	2x38	Shared	5.27	1.87	No	No	Yes	No	8	7
140	2x42	3x45	Shared	9.74	1.39	Yes	Yes	No	No	8	7
141	2x42	3x46	Shared	4.98	7.46	Yes	Yes	No	No	8	8
142	2x42	3x49	Shared	9.55	8.36	Yes	Yes	No	No	8	9
143	2x45	4x46	Shared	8.3	15.22	No	No	No	No	9	7
144	2x50	3x39	Shared	4.42	4.42	No	Yes	No	No	9	9
145	2x50	7x46	Shared	4.67	10.31	No	Yes	No	No	9	9
146	2x50	7x49	Shared	5.53	6.73	No	Yes	No	Yes	9	9
147	2x55	2x551	Shared	7.87	4.87	No	No	No	No	5	5
148	2x551	3x31	Shared	10.96	3.65	No	No	No	No	5	5
149	2x56	7x42	Shared	4.33	7.22	Yes	Yes	No	No	7	7
150	2x66	E1x51	Shared	8.74	5.17	No	No	No	No	6	3
151	E1x49	E2	Shared	7.85	19.06	No	No	Yes	Yes	5	4
152	3x25	E1x50	Shared	6.98	15.36	No	No	Yes	Yes	9	7
153	E1x50	E2	Shared	6.06	3.53	Yes	Yes	Yes	Yes	7	4
154	E1x50	E2x50	Shared	6.98	4.19	Yes	Yes	No	Yes	7	9
155	3x21	3x24	Shared	11.49	4.93	No	No	No	No	7	5
156	3x22	E2	Shared	12.44	2.61	No	No	Yes	Yes	4	4
157	3x25	E2x50	Shared	5.46	7.28	No	No	No	Yes	9	9
158	3x29	3x32	Shared	8.14	5.42	Yes	Yes	No	No	4	7
159	3x29	4x65	Shared	17.37	24.82	Yes	Yes	Yes	Yes	4	6
160	3x29	E2x50	Shared	6.47	3.23	Yes	Yes	No	Yes	4	9
161	3x30	3x34	Shared	8.83	3.79	No	Yes	No	No	7	6
162	3x30	4x54	Shared	5.86	2.34	No	Yes	No	No	7	3
163	3x33	3x37	Shared	6.09	7.18	Yes	Yes	Yes	Yes	5	6
164	3x33	4x57	Shared	9.01	6.13	Yes	Yes	No	No	5	7
165	3x33	4x61	Shared	14.64	8.16	Yes	Yes	Yes	No	5	6
166	3x34	4x57	Shared	6.46	4.85	No	No	No	No	6	7
167	3x37	3x41	Shared	6.19	4.96	Yes	Yes	No	No	6	6
168	3x37	4x56	Shared	7.87	10.55	Yes	Yes	No	Yes	6	5
169	3x37	5x461	Shared	7.87	3.79	Yes	Yes	No	No	6	5
170	3x38	4x50	Shared	5.19	3.89	No	No	Yes	Yes	7	9
171	3x40	6x44	Shared	7.78	3.82	No	No	No	Yes	8	9
172	3x42	4x50	Shared	4.56	6.98	No	No	Yes	Yes	8	9
173	3x47	5x54	Shared	4.5	3.04	No	No	No	No	8	8
174	3x48	5x57	Shared	4.76	3.17	No	No	No	No	6	6
175	3x51	5x57	Shared	7.28	2.95	No	Yes	No	No	7	6
176	3x51	5x61	Shared	4.91	3.98	No	Yes	No	No	7	8
177	4x61	4x65	Shared	5.86	7.03	Yes	No	Yes	Yes	6	6
178	4x61	5x39	Shared	6.76	5.64	Yes	No	Yes	Yes	6	7
179	4x64	4x65	Shared	6.28	7.54	Yes	No	Yes	Yes	5	6
180	4x64	E2	Shared	6.28	8.79	Yes	No	Yes	Yes	5	4
181	4x65	E2x52	Shared	6.93	4.16	Yes	Yes	No	No	6	5
182	E2	E2	Shared	38.26	43.45	Yes	Yes	Yes	Yes	4	4
183	E2	E2x51	Shared	16.62	21.37	Yes	Yes	No	No	4	3
184	5x35	E2	Shared	4.52	1.51	No	No	Yes	Yes	4	4
185	5x36	E2	Shared	21.67	6.41	No	No	Yes	Yes	5	4
186	5x39	E2	Shared	6.19	4.13	Yes	Yes	Yes	Yes	7	4
187	5x34	E2	Shared	13.7	3.94	No	No	Yes	Yes	2	4
188	5x37	6x60	Shared	13.92	13.99	No	No	No	No	4	5
189	5x39	5x43	Shared	7.25	4.84	Yes	Yes	No	Yes	7	5
190	5x40	6x59	Shared	10.75	5.09	No	No	No	No	5	4
191	5x42	5x43	Shared	7.05	4.7	No	No	No	Yes	4	5
192	5x42	5x46	Shared	7.78	10.47	No	No	No	No	4	4
193	5x44	6x52	Shared	10.38	4.16	No	No	No	Yes	5	7
194	5x44	6x56	Shared	4.52	4.73	No	No	No	No	5	6
195	5x58	6x37	Shared	7.49	5.67	Yes	No	No	No	9	8
196	6x27	6x30	Shared	6.12	4.85	No	No	No	No	4	8
197	6x36	7x56	Shared	16.17	12.44	No	No	Yes	No	8	7
198	6x39	7x52	Shared	7.36	4.61	No	No	No	No	7	8
199	6x40	7x53	Shared	6.04	6.04	Yes	No	Yes	No	8	9
200	6x44	6x48	Shared	10.02	11.58	No	Yes	Yes	Yes	9	8
201	6x47	7x45	Shared	4.72	9.45	No	No	No	Yes	8	9
202	6x48	6x52	Shared	8.02	6.01	Yes	Yes	No	Yes	8	7
203	6x48	7x45	Shared	13.56	12.43	Yes	Yes	No	Yes	8	9
204	6x51	6x52	Shared	15	11.79	No	Yes	No	Yes	7	7
205	6x51	6x55	Shared	8.2	12.88	No	Yes	No	No	7	6
206	6x54	7x37	Shared	6.41	5.96	No	No	No	No	5	5
207	6x56	6x60	Shared	6.98	3.42	No	No	No	No	6	5
208	6x57	E3	Shared	6.48	13.24	No	No	Yes	Yes	4	4
209	E3	E3	Shared	8.39	7.92	Yes	Yes	Yes	Yes	4	4
210	7x45	7x49	Shared	12.59	12.26	No	Yes	No	Yes	9	9
211	1x57	2x44	Shared	4.23	1.71	Yes	No	No	No	7	6
212	1x39	2x61	Shared	4.15	8.3	No	No	No	No	6	7
213	3x21	E1x52	Shared	4.06	4.06	No	No	No	No	7	6
214	6x58	7x34	Shared	3.96	2.77	No	No	Yes	Yes	5	4
215	6x54	7x34	Shared	3.93	7.87	No	No	Yes	Yes	5	4
216	6x32	6x35	Shared	3.71	4.95	No	No	No	No	8	8
217	2x59	3x28	Shared	3.53	1.77	No	No	No	No	4	6
218	5x49	5x50	Shared	3.53	1.87	No	No	No	No	5	9
219	6x49	6x50	Shared	3.5	1.87	No	No	No	No	6	9
220	2x53	7x46	Shared	3.42	8.08	No	Yes	No	No	7	9
221	2x58	2x59	Shared	3.28	3.28	No	No	No	No	8	4
222	2x57	7x42	Shared	3.23	3.23	No	No	No	No	7	7
223	3x55	5x64	Shared	3.23	3.04	No	No	No	No	7	6
224	3x51	5x60	Shared	3.17	5.14	No	Yes	No	No	7	6
225	1x54	2x47	Shared	3	1.59	No	No	No	No	7	9
226	1x36	2x61	Shared	2.98	4.15	No	No	No	No	6	7
227	1x38	7x39	Shared	2.98	2.77	No	No	No	No	4	5
228	3x44	5x53	Shared	2.98	1.71	Yes	No	No	No	7	6
229	3x42	4x49	Shared	2.95	3.22	No	No	No	No	8	7
230	5x61	5x65	Shared	2.94	2.94	No	No	No	No	8	8
231	4x60	5x39	Shared	2.78	2.78	No	No	Yes	Yes	7	7
232	1x35	7x35	Shared	2.73	5.7	No	Yes	No	No	5	4
233	2x49	4x50	Shared	2.59	3.89	No	No	Yes	Yes	8	9
234	5x34	5x38	Shared	2.59	2.43	No	No	No	No	2	4
235	1x57	2x40	Shared	2.44	3.86	Yes	No	No	Yes	7	9
236	3x30	3x31	Shared	2.34	3.52	No	Yes	No	No	7	5
237	1x46	7x47	Shared	1.81	3.42	No	No	No	No	8	7
238	6x43	7x48	Shared	1.81	4.76	No	No	No	No	6	6
239	8x47	8x49	Shared	1.31	4.89	No	No	No	No	8	6
240	Lig	Lig	vasop-oxy_on	0	18.21	Yes	Yes	Yes	Yes	0	0
241	7x38	Lig	vasop-oxy_on	0	7.9	No	No	Yes	Yes	6	0
242	2x60	Lig	vasop-oxy_on	0	9.02	No	Yes	Yes	Yes	7	0
243	3x33	Lig	vasop-oxy_on	0	3.73	Yes	Yes	Yes	Yes	5	0
244	5x43	Lig	vasop-oxy_on	0	3.77	No	Yes	Yes	Yes	5	0
245	5x36	Lig	vasop-oxy_on	0	16.35	No	No	Yes	Yes	5	0
246	E2x51	Lig	vasop-oxy_on	0	31.64	No	No	Yes	Yes	3	0
247	E2x52	Lig	vasop-oxy_on	0	4.69	No	No	Yes	Yes	5	0
248	E3	Lig	vasop-oxy_on	0	3.28	Yes	Yes	Yes	Yes	4	0
249	7x35	Lig	vasop-oxy_on	0	6.15	No	No	Yes	Yes	4	0
250	Lig	NT	vasop-oxy_on	0	5.33	Yes	Yes	No	No	0	0
251	1x28	Lig	vasop-oxy_on	0	4.76	No	Yes	Yes	Yes	5	0
252	1x31	Lig	vasop-oxy_on	0	10.93	No	Yes	Yes	Yes	5	0
253	1x35	Lig	vasop-oxy_on	0	4.65	No	Yes	Yes	Yes	5	0
254	E1x49	Lig	vasop-oxy_on	0	4.5	No	No	Yes	Yes	5	0
255	1x32	NT	vasop-oxy_on	0	5.53	No	No	No	No	5	0
256	2x67	NT	vasop-oxy_on	0	11.91	No	No	No	No	4	0
257	1x28	1x30	vasop-oxy_on	0	4.07	No	Yes	No	No	5	3
258	1x30	1x33	vasop-oxy_on	0	6.07	No	No	No	No	3	5
259	1x35	7x39	vasop-oxy_on	0	5.3	No	Yes	No	No	5	5
260	1x39	7x39	vasop-oxy_on	0	5.54	No	No	No	No	6	5
261	1x43	2x58	vasop-oxy_on	0	7.31	No	No	No	No	6	8
262	1x46	2x54	vasop-oxy_on	0	3.39	No	No	No	No	8	7
263	1x46	7x46	vasop-oxy_on	0	4.85	No	No	No	No	8	9
264	1x49	7x51	vasop-oxy_on	0	8.65	No	No	No	No	8	6
265	1x50	2x50	vasop-oxy_on	0	12.12	No	No	No	Yes	9	9
266	1x53	7x50	vasop-oxy_on	0	3.53	No	No	No	No	9	9
267	1x53	7x54	vasop-oxy_on	0	3.39	No	No	No	No	9	7
268	1x57	I1	vasop-oxy_on	0	6.83	Yes	No	No	Yes	7	0
269	1x59	8x53	vasop-oxy_on	0	15.12	No	No	No	Yes	0	0
270	1x59	8x56	vasop-oxy_on	0	3.95	No	No	No	No	0	0
271	1x60	I1	vasop-oxy_on	0	4.51	No	Yes	No	Yes	0	0
272	1x60	2x40	vasop-oxy_on	0	7.9	No	Yes	No	Yes	0	9
273	1x60	8x49	vasop-oxy_on	0	6.59	No	Yes	No	No	0	6
274	1x60	8x53	vasop-oxy_on	0	6.98	No	Yes	No	Yes	0	0
275	1x61	I1	vasop-oxy_on	0	5.63	No	No	No	Yes	0	0
276	1x64	I1	vasop-oxy_on	0	4.77	No	No	No	Yes	0	0
277	2x40	I1	vasop-oxy_on	0	6.35	No	Yes	No	Yes	9	0
278	4x41	I1	vasop-oxy_on	0	9.52	No	No	No	Yes	7	0
279	2x37	2x40	vasop-oxy_on	0	4.39	No	No	No	Yes	8	9
280	2x39	2x40	vasop-oxy_on	0	6.63	No	No	No	Yes	8	9
281	2x39	2x43	vasop-oxy_on	0	4.42	No	No	No	No	8	7
282	2x40	8x49	vasop-oxy_on	0	6.97	No	Yes	No	No	9	6
283	2x41	4x43	vasop-oxy_on	0	7.39	Yes	No	No	No	5	3
284	2x42	4x43	vasop-oxy_on	0	3.62	Yes	Yes	No	No	8	3
285	2x53	2x56	vasop-oxy_on	0	7.16	No	Yes	Yes	Yes	7	7
286	2x53	7x42	vasop-oxy_on	0	3.23	No	Yes	No	No	7	7
287	2x56	3x36	vasop-oxy_on	0	5.44	Yes	Yes	No	No	7	6
288	2x60	2x63	vasop-oxy_on	0	4.38	No	Yes	No	Yes	7	5
289	2x60	2x64	vasop-oxy_on	0	5.42	No	Yes	No	No	7	5
290	2x60	3x32	vasop-oxy_on	0	7.68	No	Yes	No	No	7	7
291	2x63	E1x50	vasop-oxy_on	0	8.02	No	Yes	Yes	Yes	5	7
292	2x63	E2	vasop-oxy_on	0	4.47	No	Yes	Yes	Yes	5	4
293	3x24	E1x50	vasop-oxy_on	0	6.09	No	No	Yes	Yes	5	7
294	3x28	E1x50	vasop-oxy_on	0	3.93	No	No	Yes	Yes	6	7
295	3x25	3x29	vasop-oxy_on	0	3.23	No	No	Yes	Yes	9	4
296	3x26	E2	vasop-oxy_on	0	4.15	No	No	Yes	Yes	6	4
297	3x30	4x57	vasop-oxy_on	0	5.09	No	Yes	No	No	7	7
298	3x30	4x59	vasop-oxy_on	0	7.03	No	Yes	No	No	7	4
299	3x30	4x62	vasop-oxy_on	0	4.69	No	Yes	No	No	7	5
300	3x33	3x36	vasop-oxy_on	0	5.78	Yes	Yes	No	No	5	6
301	3x34	4x53	vasop-oxy_on	0	3.23	No	No	No	No	6	8
302	3x37	5x43	vasop-oxy_on	0	4.84	Yes	Yes	No	Yes	6	5
303	3x38	4x53	vasop-oxy_on	0	3.42	No	No	No	No	7	8
304	3x40	5x50	vasop-oxy_on	0	3.56	No	No	No	No	8	9
305	3x41	5x46	vasop-oxy_on	0	3.59	No	No	No	No	6	4
306	3x42	4x46	vasop-oxy_on	0	4.56	No	No	No	No	8	7
307	3x43	5x54	vasop-oxy_on	0	4.42	No	No	No	No	8	8
308	3x43	7x49	vasop-oxy_on	0	5.66	No	No	No	Yes	8	9
309	3x43	7x53	vasop-oxy_on	0	3.63	No	No	Yes	No	8	9
310	3x46	7x53	vasop-oxy_on	0	8.38	No	No	Yes	No	8	9
311	3x49	3x52	vasop-oxy_on	0	5.96	No	No	No	Yes	9	3
312	3x50	5x58	vasop-oxy_on	0	3.5	Yes	No	Yes	No	9	9
313	3x50	5x61	vasop-oxy_on	0	3.76	Yes	No	No	No	9	8
314	3x51	3x55	vasop-oxy_on	0	10.32	No	Yes	No	No	7	7
315	3x52	3x53	vasop-oxy_on	0	4.15	No	Yes	No	No	3	8
316	3x52	I2x54	vasop-oxy_on	0	6.17	No	Yes	No	No	3	0
317	3x56	I2x52	vasop-oxy_on	0	8.5	No	No	No	No	5	0
318	4x44	I2x56	vasop-oxy_on	0	20.31	No	No	No	No	3	0
319	4x38	4x39	vasop-oxy_on	0	3.71	No	No	No	No	4	4
320	4x38	4x43	vasop-oxy_on	0	5.96	No	No	No	No	4	3
321	4x39	4x42	vasop-oxy_on	0	5.63	No	No	No	No	4	7
322	4x40	4x41	vasop-oxy_on	0	4.39	No	No	No	No	5	7
323	4x42	4x47	vasop-oxy_on	0	5.69	No	No	No	No	7	3
324	4x50	4x53	vasop-oxy_on	0	3.71	Yes	Yes	No	No	9	8
325	4x56	5x42	vasop-oxy_on	0	3.42	No	Yes	No	No	5	4
326	4x56	5x46	vasop-oxy_on	0	4.24	No	Yes	No	No	5	4
327	E2	E2x50	vasop-oxy_on	0	4.61	Yes	Yes	No	Yes	4	9
328	5x41	6x60	vasop-oxy_on	0	4.85	No	No	No	No	5	5
329	5x461	6x52	vasop-oxy_on	0	5.24	No	No	No	Yes	5	7
330	5x47	5x48	vasop-oxy_on	0	3.93	No	No	No	No	8	5
331	5x47	6x48	vasop-oxy_on	0	4.01	No	No	Yes	Yes	8	8
332	5x47	6x52	vasop-oxy_on	0	5.36	No	No	No	Yes	8	7
333	5x50	6x44	vasop-oxy_on	0	4.17	No	No	No	Yes	9	9
334	5x51	6x44	vasop-oxy_on	0	6.24	No	No	No	Yes	6	9
335	5x58	6x36	vasop-oxy_on	0	4.08	Yes	No	No	No	9	8
336	5x62	5x66	vasop-oxy_on	0	4.53	No	Yes	No	No	5	6
337	6x32	7x56	vasop-oxy_on	0	4.96	No	No	Yes	No	8	7
338	6x44	7x45	vasop-oxy_on	0	4.65	No	Yes	No	Yes	9	9
339	6x51	7x41	vasop-oxy_on	0	8.32	No	Yes	No	No	7	7
340	6x55	7x38	vasop-oxy_on	0	12.23	No	No	No	No	6	6
341	6x57	6x61	vasop-oxy_on	0	8.93	No	No	No	No	4	0
342	6x57	7x34	vasop-oxy_on	0	5.01	No	No	Yes	Yes	4	4
343	6x61	E3	vasop-oxy_on	0	17.57	No	No	Yes	Yes	0	4
344	7x34	E3	vasop-oxy_on	0	13.42	Yes	Yes	Yes	Yes	4	4
345	7x31	E3	vasop-oxy_on	0	3.27	No	No	Yes	Yes	2	4
346	7x34	7x38	vasop-oxy_on	0	3.73	Yes	Yes	No	No	4	6
347	7x40	7x43	vasop-oxy_on	0	6.92	No	No	No	No	7	5
348	7x49	7x50	vasop-oxy_on	0	3.26	No	Yes	No	No	9	9
349	8x47	8x50	vasop-oxy_on	0	6.46	No	No	No	No	8	8
350	8x53	8x56	vasop-oxy_on	0	4.31	No	Yes	No	No	0	0
351	6x47	7x43	vasop-oxy_on	0	3.17	No	No	No	No	8	5
352	1x31	7x32	vasop-oxy_on	0	3.15	No	Yes	No	No	5	2
353	1x36	2x65	vasop-oxy_on	0	3.15	No	No	No	No	6	5
354	6x43	7x52	vasop-oxy_on	0	3.07	No	No	No	No	6	8
355	1x56	8x53	vasop-oxy_on	0	3.02	No	No	No	Yes	7	0
356	6x42	6x46	vasop-oxy_on	0	2.98	No	No	No	No	5	6
357	6x36	6x40	vasop-oxy_on	0	2.92	No	No	Yes	No	8	8
358	2x42	4x45	vasop-oxy_on	0	2.89	Yes	Yes	No	No	8	5
359	4x44	4x45	vasop-oxy_on	0	2.88	No	No	No	No	3	5
360	1x38	1x39	vasop-oxy_on	0	2.77	No	No	No	No	4	6
361	1x38	7x36	vasop-oxy_on	0	2.77	No	No	No	No	4	5
362	3x44	3x48	vasop-oxy_on	0	2.77	Yes	No	No	No	7	6
363	4x55	4x56	vasop-oxy_on	0	2.77	No	No	No	Yes	3	5
364	1x50	2x51	vasop-oxy_on	0	2.75	No	No	No	No	9	7
365	2x46	7x49	vasop-oxy_on	0	2.75	No	No	No	Yes	9	9
366	4x48	4x52	vasop-oxy_on	0	2.62	No	No	No	No	4	4
367	5x62	6x30	vasop-oxy_on	0	2.62	No	Yes	No	No	5	8
368	5x62	6x34	vasop-oxy_on	0	2.62	No	Yes	No	No	5	7
369	5x62	6x33	vasop-oxy_on	0	2.59	No	Yes	No	No	5	8
370	7x52	7x56	vasop-oxy_on	0	2.51	No	No	Yes	No	8	7
371	2x41	I1	vasop-oxy_on	0	2.45	Yes	No	No	Yes	5	0
372	I2x55	I2x56	vasop-oxy_on	0	2.26	No	No	No	No	0	0
373	1x62	1x63	vasop-oxy_on	0	2.13	No	No	No	No	0	0
374	7x31	7x33	vasop-oxy_on	0	2.03	No	No	No	No	2	5
375	2x53	3x35	vasop-oxy_on	0	1.84	No	Yes	No	No	7	6
376	1x51	1x54	vasop-oxy_on	0	1.71	No	No	No	No	3	7
377	5x52	5x53	vasop-oxy_on	0	1.71	No	No	No	No	3	6
378	6x27	6x29	vasop-oxy_on	0	1.71	No	No	No	No	4	6
379	5x55	6x41	vasop-oxy_on	0	1.7	No	No	Yes	No	4	8
380	6x45	6x49	vasop-oxy_on	0	1.7	No	No	No	No	6	6
381	5x65	6x29	vasop-oxy_on	0	1.62	No	No	No	No	8	6
382	1x28	1x29	vasop-oxy_on	0	1.61	No	Yes	No	No	5	5
383	I2x56	I2x57	vasop-oxy_on	0	1.59	No	No	No	No	0	0
384	5x51	6x41	vasop-oxy_on	0	1.59	No	No	Yes	No	6	8
385	5x51	6x45	vasop-oxy_on	0	1.59	No	No	No	No	6	6
386	1x31	1x34	vasop-oxy_on	0	1.58	No	Yes	No	No	5	5
387	1x34	7x36	vasop-oxy_on	0	1.58	No	No	No	No	5	5
388	1x56	8x54	vasop-oxy_on	0	1.58	No	No	No	No	7	0
389	3x22	3x23	vasop-oxy_on	0	1.54	No	No	No	No	4	3
390	6x32	8x48	vasop-oxy_on	0	1.53	No	No	No	No	8	5
391	1x63	1x64	vasop-oxy_on	0	1.5	No	No	No	No	0	0
392	6x34	6x38	vasop-oxy_on	0	1.49	No	No	No	No	7	6
393	6x53	6x54	vasop-oxy_on	0	1.49	No	No	No	No	5	5
394	3x54	5x65	vasop-oxy_on	0	1.47	Yes	No	No	No	8	8
395	3x56	I2x50	vasop-oxy_on	0	1.44	No	No	No	No	5	0
396	6x31	6x35	vasop-oxy_on	0	1.38	No	No	No	No	6	8
397	4x44	4x48	vasop-oxy_on	0	1.31	No	No	No	No	3	4
398	5x59	5x63	vasop-oxy_on	0	1.31	No	No	No	No	3	4
399	2x63	2x66	vasop-oxy_on	0	1.21	No	Yes	No	No	5	6
400	3x52	3x56	vasop-oxy_on	0	1.07	No	Yes	No	No	3	5
401	5x62	5x63	vasop-oxy_on	0	1.07	No	Yes	No	No	5	4

Orange: nodes, hubs and links specific of vasop-oxy_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasop-oxy_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	vasop-oxy_off Avg Int. Strength	vasop-oxy_on Avg Int. Strength	vasop-oxy_off Num Of Links	vasop-oxy_on Num Of Links	ConSurf
1	1x57	vasop-oxy_off	2.7575	4.13333	4	3	7
2	I1x51	vasop-oxy_off	9.154	0	5	0	7
3	2x38	vasop-oxy_off	6.7925	1.87	4	1	7
4	2x41	vasop-oxy_off	6.47	4.92	4	2	5
5	3x44	vasop-oxy_off	4.945	2.24	4	2	7
6	3x50	vasop-oxy_off	7.615	3.63	6	2	9
7	3x54	vasop-oxy_off	5.125	1.47	4	1	8
8	I2	vasop-oxy_off	6.588	0	5	0	7
9	4x61	vasop-oxy_off	7.57	6.94333	5	3	6
10	4x64	vasop-oxy_off	7.535	8.165	4	2	5
11	5x58	vasop-oxy_off	8.3925	4.41667	4	3	9
12	6x40	vasop-oxy_off	5.14	4.48	4	2	8
13	6x41	vasop-oxy_off	6.06	1.645	4	2	8
14	7x53	vasop-oxy_off	7.5775	6.01667	4	3	9
15	7x56	vasop-oxy_off	7.765	6.63667	4	3	7
16	Lig	Shared	10.888	9.64909	10	22	0
17	2x42	Shared	5.935	4.744	6	5	8
18	2x56	Shared	12.8925	8.055	4	4	7
19	E1x50	Shared	6.135	6.85333	4	6	7
20	3x29	Shared	8.646	9.175	5	4	4
21	3x33	Shared	8.8625	6.196	4	5	5
22	3x37	Shared	6.442	6.264	5	5	6
23	4x50	Shared	4.4075	4.6175	4	4	9
24	4x65	Shared	8.408	10.8875	5	4	6
25	E2	Shared	14.7175	12.2486	12	14	4
26	5x39	Shared	7.014	4.3475	5	4	7
27	6x48	Shared	8.84333	8.5075	6	4	8
28	E3	Shared	6.2075	9.51714	4	7	4
29	7x34	Shared	3.1975	6.56	4	5	4
30	1x28	vasop-oxy_on	9.61	3.9675	1	4	5
31	1x31	vasop-oxy_on	9.61	5.2725	1	4	5
32	1x35	vasop-oxy_on	6.56667	5.6	3	4	5
33	1x60	vasop-oxy_on	0	6.495	0	4	0
34	I1	vasop-oxy_on	0	5.72286	0	7	0
35	2x40	vasop-oxy_on	2.44	6.01667	1	6	9
36	2x50	vasop-oxy_on	4.87333	8.395	3	4	9
37	2x53	vasop-oxy_on	3.42	5.0775	1	4	7
38	2x60	vasop-oxy_on	5.96	6.625	2	4	7
39	2x63	vasop-oxy_on	6.8	4.52	2	4	5
40	3x30	vasop-oxy_on	5.67667	4.41	3	6	7
41	3x51	vasop-oxy_on	5.12	5.5975	3	4	7
42	3x52	vasop-oxy_on	5.54	4.3375	1	4	3
43	4x56	vasop-oxy_on	7.87	5.245	1	4	5
44	E2x50	vasop-oxy_on	6.30333	4.8275	3	4	9
45	5x43	vasop-oxy_on	6.67	4.5375	3	4	5
46	5x62	vasop-oxy_on	0	2.686	0	5	5
47	6x44	vasop-oxy_on	8.9	6.092	2	5	9
48	6x51	vasop-oxy_on	10.8433	10.0925	3	4	7
49	6x52	vasop-oxy_on	11.1333	6.512	3	5	7
50	7x45	vasop-oxy_on	10.29	9.6975	3	4	9
51	7x49	vasop-oxy_on	7.98	6.132	3	5	9
52	8x53	vasop-oxy_on	0	7.3575	0	4	0

Orange: nodes, hubs and links specific of vasop-oxy_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasop-oxy_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	vasop-oxy_off Recurrence	vasop-oxy_on Recurrence	vasop-oxy_off Hub1?	vasop-oxy_on Hub1?	vasop-oxy_off Hub2?	vasop-oxy_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	vasop-oxy_off	22.7759	0	No	Yes	No	No	5	6
2	1x39	7x38	vasop-oxy_off	28.9543	0	No	No	No	No	6	6
3	2x60	7x38	vasop-oxy_off	30.215	0	No	Yes	No	No	7	6
4	2x56	2x60	vasop-oxy_off	31.7433	0	Yes	Yes	No	Yes	7	7
5	1x38	7x39	vasop-oxy_off	13.1972	1.20402	No	No	No	No	4	5
6	7x35	7x39	vasop-oxy_off	14.8237	0	No	No	No	No	4	5
7	1x35	7x35	vasop-oxy_off	16.4229	0.0240204	No	Yes	No	No	5	4
8	1x53	2x47	vasop-oxy_off	10.2281	7.62949	No	No	No	No	9	9
9	1x53	7x53	vasop-oxy_off	18.5133	0	No	No	Yes	No	9	9
10	6x40	7x49	vasop-oxy_off	47.8059	0	Yes	No	No	Yes	8	9
11	6x48	Lig	vasop-oxy_off	66.6849	0	Yes	Yes	Yes	Yes	8	0
12	2x38	I1x51	vasop-oxy_off	10.37	0	Yes	No	Yes	No	7	7
13	3x50	I1x51	vasop-oxy_off	54.017	0	Yes	No	Yes	No	9	7
14	3x50	6x37	vasop-oxy_off	62.0511	0	Yes	No	No	No	9	8
15	5x58	6x37	vasop-oxy_off	100	1.4112	Yes	No	No	No	9	8
16	5x58	6x41	vasop-oxy_off	79.1562	0	Yes	No	Yes	No	9	8
17	3x43	6x41	vasop-oxy_off	35.2854	0	No	No	Yes	No	8	8
18	3x43	6x40	vasop-oxy_off	35.6784	0	No	No	Yes	No	8	8
19	2x38	2x42	vasop-oxy_off	10.1081	0	Yes	No	Yes	Yes	7	8
20	3x46	6x37	vasop-oxy_off	36.7373	0	No	No	No	No	8	8
21	6x41	6x45	vasop-oxy_off	22.1755	0	Yes	No	No	No	8	6
22	6x45	6x46	vasop-oxy_off	22.2028	0	No	No	No	No	6	6
23	6x46	6x47	vasop-oxy_off	22.5849	0	No	No	No	No	6	8
24	6x47	7x45	vasop-oxy_off	23.1798	2.8254	No	No	No	Yes	8	9
25	I1x51	I2	vasop-oxy_off	45.9066	0	Yes	No	Yes	No	7	7
26	2x41	2x42	vasop-oxy_off	20.4999	0	Yes	No	Yes	Yes	5	8
27	2x41	2x45	vasop-oxy_off	16.3465	0	Yes	No	No	No	5	9
28	2x45	4x50	vasop-oxy_off	14.076	0	No	No	Yes	Yes	9	9
29	3x30	3x34	vasop-oxy_off	10.179	0.186158	No	Yes	No	No	7	6
30	3x33	4x61	vasop-oxy_off	43.2267	2.78337	Yes	Yes	Yes	No	5	6
31	4x61	Lig	vasop-oxy_off	31.9998	0	Yes	No	Yes	Yes	6	0
32	4x61	4x64	vasop-oxy_off	22.3393	0	Yes	No	Yes	No	6	5
33	4x64	E2	vasop-oxy_off	29.571	2.42306	Yes	No	Yes	Yes	5	4
34	E1x49	E1x51	vasop-oxy_off	12.4059	0	No	No	No	No	5	3
35	4x65	Lig	vasop-oxy_off	10.632	0	Yes	Yes	Yes	Yes	6	0
36	4x61	5x39	vasop-oxy_off	26.7656	1.04189	Yes	No	Yes	Yes	6	7
37	5x39	E2	vasop-oxy_off	34.7397	1.6484	Yes	Yes	Yes	Yes	7	4
38	3x29	Lig	vasop-oxy_off	11.8382	0	Yes	Yes	Yes	Yes	4	0
39	E1x50	E1x52	vasop-oxy_off	11.0305	0	Yes	Yes	No	No	7	6
40	3x22	E2	vasop-oxy_off	15.8716	5.58174	No	No	Yes	Yes	4	4
41	3x22	3x26	vasop-oxy_off	12.4059	0	No	No	No	No	4	6
42	3x33	3x37	vasop-oxy_off	55.5889	8.75544	Yes	Yes	Yes	Yes	5	6
43	3x33	5x43	vasop-oxy_off	19.0973	0	Yes	Yes	No	Yes	5	5
44	5x39	5x43	vasop-oxy_off	17.6018	2.99354	Yes	Yes	No	Yes	7	5
45	3x37	3x41	vasop-oxy_off	55.4143	1.44123	Yes	Yes	No	No	6	6
46	3x41	3x44	vasop-oxy_off	55.4197	0	No	No	Yes	No	6	7
47	3x44	5x54	vasop-oxy_off	55.3979	0	Yes	No	No	No	7	8
48	3x47	5x54	vasop-oxy_off	27.0003	1.4112	No	No	No	No	8	8
49	6x30	I2	vasop-oxy_off	33.4025	0	No	No	Yes	No	8	7
50	3x54	6x30	vasop-oxy_off	29.0143	0	Yes	No	No	No	8	8
51	3x54	5x61	vasop-oxy_off	13.7867	0	Yes	No	No	No	8	8
52	5x44	6x52	vasop-oxy_off	15.6206	4.75604	No	No	No	Yes	5	7
53	6x55	Lig	vasop-oxy_off	16.0899	0.375319	No	No	Yes	Yes	6	0
54	6x55	7x34	vasop-oxy_off	15.3913	0	No	No	Yes	Yes	6	4
55	6x54	7x34	vasop-oxy_off	11.0632	8.03183	No	No	Yes	Yes	5	4
56	6x40	7x52	vasop-oxy_off	13.9068	0	Yes	No	No	No	8	8
57	6x39	7x52	vasop-oxy_off	10.2827	1.40219	No	No	No	No	7	8
58	5x54	6x41	vasop-oxy_off	29.3854	0	No	No	Yes	No	8	8
59	3x47	5x58	vasop-oxy_off	26.52	0	No	No	Yes	No	8	9
60	6x40	7x53	Shared	23.862	46.2603	Yes	No	Yes	No	8	9
61	7x45	7x49	Shared	49.1813	58.9551	No	Yes	No	Yes	9	9
62	6x48	7x45	Shared	71.2913	56.4089	Yes	Yes	No	Yes	8	9
63	2x56	Lig	Shared	38.8877	49.0617	Yes	Yes	Yes	Yes	7	0
64	2x42	3x46	Shared	33.2114	59.5796	Yes	Yes	No	No	8	8
65	3x34	4x57	Shared	13.5302	17.1025	No	No	No	No	6	7
66	3x33	4x57	Shared	15.173	32.2564	Yes	Yes	No	No	5	7
67	E1x49	E2	Shared	15.8825	14.9557	No	No	Yes	Yes	5	4
68	6x48	6x52	Shared	13.1318	61.5583	Yes	Yes	No	Yes	8	7
69	2x60	Lig	vasop-oxy_on	0	11.8391	No	Yes	Yes	Yes	7	0
70	2x59	3x28	vasop-oxy_on	3.71684	11.5718	No	No	No	No	4	6
71	3x28	E1x50	vasop-oxy_on	0	14.9677	No	No	Yes	Yes	6	7
72	2x60	2x63	vasop-oxy_on	0	10.5029	No	Yes	No	Yes	7	5
73	E1x50	E2	vasop-oxy_on	9.22934	22.4351	Yes	Yes	Yes	Yes	7	4
74	E1x49	Lig	vasop-oxy_on	0	15.8805	No	No	Yes	Yes	5	0
75	E2	E2x51	vasop-oxy_on	3.77688	14.9557	Yes	Yes	No	No	4	3
76	E2x51	Lig	vasop-oxy_on	0	15.7484	No	No	Yes	Yes	3	0
77	5x36	E2	vasop-oxy_on	4.14256	14.9287	No	No	Yes	Yes	5	4
78	5x36	Lig	vasop-oxy_on	0	15.6913	No	No	Yes	Yes	5	0
79	2x53	7x46	vasop-oxy_on	1.32082	55.5472	No	Yes	No	No	7	9
80	2x53	2x56	vasop-oxy_on	0	55.1269	No	Yes	Yes	Yes	7	7
81	2x50	7x46	vasop-oxy_on	3.94062	54.5203	No	Yes	No	No	9	9
82	7x49	7x50	vasop-oxy_on	0	10.4129	No	Yes	No	No	9	9
83	2x50	7x49	vasop-oxy_on	6.51676	50.2507	No	Yes	No	Yes	9	9
84	6x51	6x52	vasop-oxy_on	6.4076	52.7518	No	Yes	No	Yes	7	7
85	6x51	Lig	vasop-oxy_on	6.39668	50.2897	No	Yes	Yes	Yes	7	0
86	1x53	7x50	vasop-oxy_on	0	11.4187	No	No	No	No	9	9
87	2x41	I1	vasop-oxy_on	0	34.5654	Yes	No	No	Yes	5	0
88	2x41	4x43	vasop-oxy_on	0	35.8234	Yes	No	No	No	5	3
89	2x42	4x43	vasop-oxy_on	0	41.7925	Yes	Yes	No	No	8	3
90	3x46	7x53	vasop-oxy_on	0	60.7086	No	No	Yes	No	8	9
91	3x43	7x53	vasop-oxy_on	0	97.3067	No	No	Yes	No	8	9
92	3x43	7x49	vasop-oxy_on	0	100	No	No	No	Yes	8	9
93	2x40	I1	vasop-oxy_on	0	10.8542	No	Yes	No	Yes	9	0
94	1x60	I1	vasop-oxy_on	0	12.2744	No	Yes	No	Yes	0	0
95	4x50	4x53	vasop-oxy_on	0	11.5628	Yes	Yes	No	No	9	8
96	3x34	4x53	vasop-oxy_on	0	15.3941	No	No	No	No	6	8
97	3x33	Lig	vasop-oxy_on	0	20.9638	Yes	Yes	Yes	Yes	5	0
98	3x30	4x57	vasop-oxy_on	0	13.3013	No	Yes	No	No	7	7
99	3x24	E1x50	vasop-oxy_on	0	11.5718	No	No	Yes	Yes	5	7
100	3x37	5x461	vasop-oxy_on	1.7247	11.5028	Yes	Yes	No	No	6	5
101	5x461	6x52	vasop-oxy_on	0	11.5358	No	No	No	Yes	5	7
102	3x50	5x58	vasop-oxy_on	0	30.551	Yes	No	Yes	No	9	9
103	5x58	6x36	vasop-oxy_on	0	32.8689	Yes	No	No	No	9	8
104	6x36	6x40	vasop-oxy_on	0	45.2695	No	No	Yes	No	8	8
105	3x50	5x61	vasop-oxy_on	0	29.4791	Yes	No	No	No	9	8
106	3x51	5x61	vasop-oxy_on	9.29484	12.4876	No	Yes	No	No	7	8
107	6x27	6x30	vasop-oxy_on	2.33599	11.1425	No	No	No	No	4	8
108	6x27	6x29	vasop-oxy_on	0	12.5086	No	No	No	No	4	6
109	5x65	6x29	vasop-oxy_on	0	13.6436	No	No	No	No	8	6
110	5x61	5x65	vasop-oxy_on	2.33599	16.3459	No	No	No	No	8	8
111	6x36	7x56	vasop-oxy_on	3.92424	12.4726	No	No	Yes	No	8	7
112	E3	Lig	vasop-oxy_on	0	10.8272	Yes	Yes	Yes	Yes	4	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	Lig	Shared	30.6	12.4	1	1	1	0
3x29	Lig	vasop-oxy_off	9.73	0	1	1	1	0
3x32	Lig	Shared	16.32	4.51	1	1	1	0
3x36	Lig	Shared	8.67	6.08	1	1	1	0
4x61	Lig	vasop-oxy_off	5.1	0	1	0	1	0
4x65	Lig	vasop-oxy_off	5.6	0	1	0	1	0
5x40	Lig	Shared	5.47	7.98	0	1	1	0
6x48	Lig	vasop-oxy_off	7.86	0	1	1	1	0
6x51	Lig	Shared	9.33	7.38	1	1	1	0
6x55	Lig	Shared	10.2	20.81	1	1	1	0
1x28	1x31	Shared	9.61	5.43	0	1	1	1
1x35	2x64	Shared	12.99	6.75	0	1	1	2
2x56	2x60	vasop-oxy_off	5.12	0	1	1	1	1
2x56	3x32	vasop-oxy_off	11.52	0	1	1	1	1
2x56	7x42	Shared	4.33	7.22	1	1	1	2
2x60	7x38	vasop-oxy_off	6.8	0	0	1	1	1
2x63	2x64	vasop-oxy_off	5.58	0	0	1	2	2
2x63	2x67	vasop-oxy_off	8.02	0	0	1	2	2
E1x49	E1x51	vasop-oxy_off	23.66	0	1	1	1	2
E1x49	E2	Shared	7.85	19.06	1	1	1	2
3x25	E2	vasop-oxy_off	4.76	0	1	1	2	2
3x25	E2x50	Shared	5.46	7.28	1	1	2	2
3x29	3x32	Shared	8.14	5.42	1	1	1	1
3x29	4x65	Shared	17.37	24.82	1	1	1	1
3x29	E2x50	Shared	6.47	3.23	1	1	1	2
3x33	3x37	Shared	6.09	7.18	0	1	1	2
3x33	4x57	Shared	9.01	6.13	0	1	1	2
3x33	4x61	Shared	14.64	8.16	0	1	1	1
3x33	5x43	vasop-oxy_off	5.71	0	0	1	1	1
3x36	6x48	vasop-oxy_off	5.82	0	1	1	1	1
4x61	4x64	vasop-oxy_off	5.49	0	1	0	1	2
4x61	4x65	Shared	5.86	7.03	1	0	1	1
4x61	5x39	Shared	6.76	5.64	1	0	1	2
4x64	4x65	Shared	6.28	7.54	1	1	2	1
4x64	E2	Shared	6.28	8.79	1	1	2	2
4x64	5x39	vasop-oxy_off	12.09	0	1	1	2	2
4x65	E2x52	Shared	6.93	4.16	1	0	1	1
E2	E2	Shared	38.26	43.45	1	1	2	2
E2	E2x51	Shared	16.62	21.37	1	1	2	1
5x36	E2	Shared	21.67	6.41	0	1	1	2
5x39	E2	Shared	6.19	4.13	1	1	2	2
5x39	5x43	Shared	7.25	4.84	1	1	2	1
5x40	6x59	Shared	10.75	5.09	0	1	1	2
5x42	5x43	Shared	7.05	4.7	0	1	2	1
6x44	6x48	Shared	10.02	11.58	0	1	2	1
6x48	6x52	Shared	8.02	6.01	1	1	1	2
6x48	7x41	vasop-oxy_off	7.78	0	1	1	1	2
6x48	7x45	Shared	13.56	12.43	1	1	1	2
6x51	6x52	Shared	15	11.79	1	1	1	2
6x51	6x55	Shared	8.2	12.88	1	1	1	1
6x57	E3	Shared	6.48	13.24	0	1	2	1
E3	E3	Shared	8.39	7.92	0	1	1	1
7x35	7x39	vasop-oxy_off	4.28	0	0	1	1	2
1x35	1x39	vasop-oxy_off	3.98	0	0	1	1	2
6x55	7x34	vasop-oxy_off	3.51	0	1	1	1	2
1x39	7x38	vasop-oxy_off	2.83	0	0	1	2	1
1x35	7x35	Shared	2.73	5.7	0	1	1	1
7x30	E3	vasop-oxy_off	1.57	0	0	0	2	1
3x28	3x29	vasop-oxy_off	1.52	0	0	0	2	1
7x38	Lig	vasop-oxy_on	0	7.9	0	1	1	0
2x60	Lig	vasop-oxy_on	0	9.02	0	1	1	0
3x33	Lig	vasop-oxy_on	0	3.73	0	1	1	0
5x43	Lig	vasop-oxy_on	0	3.77	0	1	1	0
5x36	Lig	vasop-oxy_on	0	16.35	0	1	1	0
E2x51	Lig	vasop-oxy_on	0	31.64	0	1	1	0
E2x52	Lig	vasop-oxy_on	0	4.69	0	1	1	0
E3	Lig	vasop-oxy_on	0	3.28	0	1	1	0
7x35	Lig	vasop-oxy_on	0	6.15	0	1	1	0
Lig	NT	vasop-oxy_on	0	5.33	1	1	0	1
1x28	Lig	vasop-oxy_on	0	4.76	0	1	1	0
1x31	Lig	vasop-oxy_on	0	10.93	0	1	1	0
1x35	Lig	vasop-oxy_on	0	4.65	0	1	1	0
E1x49	Lig	vasop-oxy_on	0	4.5	1	1	1	0
1x32	NT	vasop-oxy_on	0	5.53	0	0	2	1
2x67	NT	vasop-oxy_on	0	11.91	0	0	2	1
1x28	1x30	vasop-oxy_on	0	4.07	0	1	1	2
1x35	7x39	vasop-oxy_on	0	5.3	0	1	1	2
1x39	7x39	vasop-oxy_on	0	5.54	0	1	2	2
2x53	2x56	vasop-oxy_on	0	7.16	0	1	2	1
2x53	7x42	vasop-oxy_on	0	3.23	0	1	2	2
2x56	3x36	vasop-oxy_on	0	5.44	1	1	1	1
2x60	2x63	vasop-oxy_on	0	4.38	0	1	1	2
2x60	2x64	vasop-oxy_on	0	5.42	0	1	1	2
2x60	3x32	vasop-oxy_on	0	7.68	0	1	1	1
2x63	E2	vasop-oxy_on	0	4.47	0	1	2	2
3x25	3x29	vasop-oxy_on	0	3.23	1	1	2	1
3x33	3x36	vasop-oxy_on	0	5.78	0	1	1	1
3x37	5x43	vasop-oxy_on	0	4.84	0	0	2	1
E2	E2x50	vasop-oxy_on	0	4.61	1	1	2	2
5x47	6x48	vasop-oxy_on	0	4.01	0	1	2	1
5x47	6x52	vasop-oxy_on	0	5.36	0	1	2	2
6x44	7x45	vasop-oxy_on	0	4.65	0	1	2	2
6x51	7x41	vasop-oxy_on	0	8.32	1	1	1	2
6x55	7x38	vasop-oxy_on	0	12.23	1	1	1	1
6x57	6x61	vasop-oxy_on	0	8.93	0	1	2	2
6x57	7x34	vasop-oxy_on	0	5.01	0	1	2	2
6x61	E3	vasop-oxy_on	0	17.57	0	1	2	1
7x34	E3	vasop-oxy_on	0	13.42	0	1	2	1
7x31	E3	vasop-oxy_on	0	3.27	0	1	2	1
7x34	7x38	vasop-oxy_on	0	3.73	0	1	2	1
1x31	7x32	vasop-oxy_on	0	3.15	0	1	1	2
1x28	1x29	vasop-oxy_on	0	1.61	0	1	1	2
1x31	1x34	vasop-oxy_on	0	1.58	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	vasop-oxy_off	ot_off
	vasop-oxy_on	v2_on

Network Difference
Value	vasop-oxy_off	vasop-oxy_on
I_min	4.28	3.23
Number of Linked Nodes	220	234
Number of Specific Nodes	21 (9.55%)	35 (14.96%)
Number of Shared Nodes	199 (90.45%)	199 (85.04%)
Number of Links	239	277
Number of Specific Links	124 (51.88%)	162 (58.48%)
Number of Shared Links	115 (48.12%)	115 (41.52%)
Number of Hubs	29	37
Number of Specific Hubs	15 (51.72%)	23 (62.16%)
Number of Shared Hubs	14 (48.28%)	14 (37.84%)
Average % Shared Neighbours (Jaccard)	28.09
Average % Shared Neighbours (Otsuka)	36.70
Average % Shared Neighbours (Overlap Coefficient)	45.72
Average % Shared Cliques (k3-6)	76.25
Graphlets Similarity	0.583688

Paths Difference
Value	vasop-oxy_off	vasop-oxy_on
Number Of Nodes in MetaPath	64	51
Specific Nodes in MetaPath	37 (57.81%)	24 (47.06%)
Shared Nodes in MetaPath	199 (90.45%)	199 (90.45%)
Number Of Links MetaPath	68	53
Specific Links in MetaPath	59 (86.76%)	44 (83.02%)
Shared Links in MetaPath	115 (48.12%)	115 (48.12%)
Number of Shortest Paths	37840	57566
Length Of Smallest Path	3	3
Average Path Length	13.0741	13.6294
Length of Longest Path	30	28
Minimum Path Strength	1.22	1.19
Average Path Strength	7.23118	6.67444
Maximum Path Strength	19.145	19.6967
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.906758	0.919462
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	5.26316
Average % Of Corr. Nodes	37.896	45.5495
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.9451	45.9975
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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