psnGPCR

Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	6931074
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XIP

Peptide

Somatostatin

SST1

Homo Sapiens

Pasireotide

chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2

3.29

2024-07-03

doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of 004 in 8XIP
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	16.88	3	Yes	Yes	0	0	0	1
L:L:?1	L:L:?4	10.1	3	Yes	Yes	0	0	0	1
L:L:?1	L:L:?6	25.42	3	Yes	Yes	0	0	0	1
L:L:?1	R:R:N209	6.66	3	Yes	No	0	5	0	1
L:L:?1	R:R:M210	5.71	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:L220	3.36	3	Yes	Yes	0	5	0	1
L:L:?2	L:L:K3	27.98	3	Yes	Yes	0	0	1	2
L:L:?2	L:L:?4	3.61	3	Yes	Yes	0	0	1	1
L:L:?2	R:R:M141	3.37	3	Yes	Yes	0	7	1	2
L:L:?2	R:R:M210	7.85	3	Yes	Yes	0	4	1	1
L:L:?2	R:R:Q291	7.4	3	Yes	No	0	6	1	2
L:L:?4	L:L:K3	4.63	3	Yes	Yes	0	0	1	2
L:L:K3	R:R:D137	11.06	3	Yes	Yes	0	6	2	2
L:L:K3	R:R:M141	2.88	3	Yes	Yes	0	7	2	2
L:L:?4	L:L:?6	5.16	3	Yes	Yes	0	0	1	1
L:L:?4	R:R:L114	18.17	3	Yes	No	0	6	1	2
L:L:?4	R:R:S117	8.62	3	Yes	No	0	6	1	2
L:L:?4	R:R:L134	7.95	3	Yes	No	0	5	1	2
L:L:?4	R:R:D137	10.02	3	Yes	Yes	0	6	1	2
L:L:?4	R:R:N209	4.51	3	Yes	No	0	5	1	1
L:L:?6	L:L:F5	11.07	3	Yes	No	0	0	1	2
L:L:?6	R:R:D300	4.62	3	Yes	No	0	4	1	2
R:R:I192	R:R:M210	2.92	3	No	Yes	5	4	2	1
R:R:F223	R:R:I192	10.05	3	No	No	6	5	2	2
R:R:A207	R:R:N209	3.13	0	No	No	5	5	2	1
R:R:F223	R:R:M210	6.22	3	No	Yes	6	4	2	1
R:R:L220	R:R:M212	7.07	3	Yes	No	5	4	1	2
R:R:L220	R:R:V224	2.98	3	Yes	No	5	5	1	2
R:R:L220	R:R:V295	5.96	3	Yes	No	5	4	1	2
R:R:V224	R:R:V295	3.21	3	No	No	5	4	2	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	11.35
Average Nodes In Shell	22.00
Average Hubs In Shell	9.00
Average Links In Shell	30.00
Average Links Mediated by Hubs In Shell	27.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8XIR

Peptide

Somatostatin

SST3

Homo Sapiens

Pasireotide

chim(NtGi1-Gs-CtGi1)/Beta1/Gamma2

2.52

2024-07-03

doi.org/10.1073/pnas.2400298121

A 2D representation of the interactions of 004 in 8XIR
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	13.32	2	Yes	Yes	0	0	0	1
L:L:?1	L:L:?4	9.18	2	Yes	Yes	0	0	0	1
L:L:?1	L:L:?6	25.64	2	Yes	Yes	0	0	0	1
L:L:?1	R:R:H192	6.24	2	Yes	No	0	4	0	1
L:L:?1	R:R:W195	11.97	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:R203	11.79	2	Yes	Yes	0	4	0	1
L:L:?2	L:L:K3	22.39	2	Yes	Yes	0	0	1	2
L:L:?2	L:L:?4	4.51	2	Yes	Yes	0	0	1	1
L:L:?2	R:R:M120	3.37	2	Yes	Yes	0	4	1	2
L:L:?2	R:R:D123	3.23	2	Yes	Yes	0	6	1	2
L:L:?2	R:R:Q127	6.34	2	Yes	Yes	0	7	1	2
L:L:?2	R:R:M193	6.73	2	Yes	Yes	0	4	1	2
L:L:?2	R:R:T210	4.68	2	Yes	No	0	5	1	2
L:L:?2	R:R:F273	7.73	2	Yes	Yes	0	6	1	2
L:L:?2	R:R:N277	3.27	2	Yes	No	0	6	1	2
L:L:K3	R:R:D123	12.44	2	Yes	Yes	0	6	2	2
L:L:K3	R:R:Q127	4.07	2	Yes	Yes	0	7	2	2
L:L:K3	R:R:F273	6.2	2	Yes	Yes	0	6	2	2
L:L:?4	L:L:?6	9.37	2	Yes	Yes	0	0	1	1
L:L:?4	R:R:L100	14.76	2	Yes	Yes	0	7	1	2
L:L:?4	R:R:Q103	9.83	2	Yes	No	0	5	1	2
L:L:?4	R:R:W109	4.67	2	Yes	Yes	0	8	1	2
L:L:?4	R:R:V119	13.44	2	Yes	No	0	5	1	2
L:L:?4	R:R:M120	4.64	2	Yes	Yes	0	4	1	2
L:L:?4	R:R:D123	6.68	2	Yes	Yes	0	6	1	2
L:L:?4	R:R:C191	2.6	2	Yes	No	0	9	1	2
L:L:?6	L:L:F5	25.68	2	Yes	No	0	0	1	2
L:L:?6	R:R:E287	6.07	2	Yes	No	0	1	1	2
R:R:Q103	R:R:W109	4.38	2	No	Yes	5	8	2	2
R:R:C191	R:R:W109	11.75	2	No	Yes	9	8	2	2
R:R:M120	R:R:M193	8.66	2	Yes	Yes	4	4	2	2
R:R:H192	R:R:T190	15.06	0	No	No	4	4	1	2
R:R:M193	R:R:W195	5.82	2	Yes	Yes	4	6	2	1
R:R:R203	R:R:W195	8	2	Yes	Yes	4	6	1	1
R:R:F206	R:R:W195	6.01	0	No	Yes	5	6	2	1
R:R:A199	R:R:R203	9.68	0	No	Yes	4	4	2	1
R:R:R203	R:R:V281	3.92	2	Yes	Yes	4	5	1	2
R:R:G187	R:R:H192	1.59	0	No	No	4	4	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	13.02
Average Nodes In Shell	27.00
Average Hubs In Shell	15.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8ZCJ

Peptide

Somatostatin

SST5

Homo Sapiens

Pasireotide

Gi1/Beta1/Gamma1

3.09

2024-07-10

10.1038/s41401-024-01314-8

A 2D representation of the interactions of 004 in 8ZCJ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	18.22	1	Yes	Yes	0	0	0	1
L:L:?1	L:L:?6	20.99	1	Yes	No	0	0	0	1
L:L:?1	R:R:I202	4.52	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N268	7.61	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:N271	6.53	1	Yes	No	0	4	0	1
L:L:?2	L:L:K3	12.27	1	Yes	Yes	0	0	1	2
L:L:?2	R:R:Q123	8.43	1	Yes	Yes	0	7	1	2
L:L:?2	R:R:F124	3.86	1	Yes	Yes	0	6	1	2
L:L:?2	R:R:F201	3.86	1	Yes	Yes	0	5	1	2
L:L:?2	R:R:F264	4.82	1	Yes	Yes	0	7	1	2
L:L:?2	R:R:N268	8.69	1	Yes	Yes	0	5	1	1
L:L:K3	R:R:F264	8.69	1	Yes	Yes	0	7	2	2
L:L:?5	L:L:?6	31.44	1	Yes	No	0	0	2	1
L:L:?5	R:R:L276	5.39	1	Yes	Yes	0	1	2	2
L:L:?5	R:R:Y286	13.69	1	Yes	No	0	4	2	2
L:L:?6	R:R:N271	8.76	1	No	No	0	4	1	1
R:R:F124	R:R:Q123	8.2	1	Yes	Yes	6	7	2	2
R:R:A199	R:R:L272	4.73	0	No	No	3	4	2	1
R:R:F201	R:R:I202	3.77	0	Yes	Yes	5	5	2	1
R:R:I202	R:R:N268	4.25	1	Yes	Yes	5	5	1	1
R:R:N268	R:R:V267	4.43	1	Yes	No	5	5	1	2
R:R:V267	R:R:Y286	11.36	1	No	No	5	4	2	2
R:R:N268	R:R:Y286	4.65	1	Yes	No	5	4	1	2
R:R:L276	R:R:N271	6.87	1	Yes	No	1	4	2	1
L:L:?1	R:R:L272	2.19	1	Yes	No	0	4	0	1
R:R:I202	R:R:I269	1.47	1	Yes	No	5	6	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	10.01
Average Nodes In Shell	18.00
Average Hubs In Shell	11.00
Average Links In Shell	26.00
Average Links Mediated by Hubs In Shell	23.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.33
Average Interaction Strength	11.46
Average Nodes In Shell	22.33
Average Hubs In Shell	11.67
Average Links In Shell	31.33
Average Links Mediated by Hubs In Shell	28.67

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)