Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4DAJ | A | Amine | Acetylcholine (muscarinic) | M3 | Rattus norvegicus | Tiotropium | - | - | 3.4 | 2012-02-22 | 10.1038/nature10867 |
![](/psngpcr/ligands/0HK/0HK_4DAJ_L_L_1.png)
A 2D representation of the interactions of 0HK in 4DAJ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D147 | R:R:S120 | 10.31 | 1 | No | No | 9 | 9 | 1 | 2 | R:R:S120 | R:R:Y533 | 5.09 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:F124 | R:R:Y529 | 11.35 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F124 | R:R:Y533 | 8.25 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:D147 | R:R:Y533 | 6.9 | 1 | No | Yes | 9 | 9 | 1 | 2 | L:L:?1 | R:R:D147 | 4.33 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:W199 | R:R:Y148 | 12.54 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:I222 | R:R:Y148 | 9.67 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Y148 | R:R:Y529 | 5.96 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:Y148 | 26.95 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:S151 | 10.55 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:N152 | R:R:W199 | 13.56 | 0 | No | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W199 | 8.73 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F239 | R:R:Y240 | 13.41 | 1 | Yes | No | 9 | 8 | 2 | 2 | R:R:F239 | R:R:W503 | 7.02 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F239 | R:R:N507 | 27.79 | 1 | Yes | No | 9 | 9 | 2 | 1 | R:R:N507 | R:R:Y240 | 9.3 | 1 | No | No | 9 | 8 | 1 | 2 | R:R:F499 | R:R:W503 | 22.05 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:T502 | R:R:W503 | 4.85 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:N535 | R:R:T502 | 7.31 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:N535 | R:R:W503 | 4.52 | 1 | No | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W503 | 11.64 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:V510 | R:R:Y506 | 3.79 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:W525 | R:R:Y506 | 3.86 | 1 | Yes | Yes | 5 | 9 | 2 | 1 | R:R:Y506 | R:R:Y529 | 6.95 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:C532 | R:R:Y506 | 4.03 | 1 | No | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:Y506 | 11.98 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:N507 | 7.89 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:Y529 | R:R:Y533 | 6.95 | 1 | Yes | Yes | 7 | 9 | 1 | 2 | L:L:?1 | R:R:Y529 | 17.22 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:C532 | 9.12 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:T234 | R:R:W199 | 3.64 | 0 | No | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:A235 | 2.01 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:A238 | 2.01 | 1 | Yes | No | 0 | 9 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 10.22 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 32.00 |
| ![](/psngpcr/ligands/0HK/0HK_4DAJ_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_4DAJ_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4U14 | A | Amine | Acetylcholine (muscarinic) | M3 | Rattus norvegicus | Tiotropium | - | - | 3.57 | 2014-11-26 | 10.1016/j.str.2014.08.022 |
![](/psngpcr/ligands/0HK/0HK_4U14_L_L_1.png)
A 2D representation of the interactions of 0HK in 4U14 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I116 | R:R:S120 | 4.64 | 1 | No | No | 9 | 9 | 2 | 2 | R:R:D147 | R:R:I116 | 5.6 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:D147 | R:R:S120 | 11.78 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:S120 | R:R:Y533 | 5.09 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:F124 | R:R:W143 | 5.01 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:F124 | R:R:Y529 | 14.44 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F124 | R:R:Y533 | 4.13 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:L144 | R:R:W143 | 7.97 | 0 | No | Yes | 8 | 7 | 2 | 2 | R:R:D147 | R:R:W143 | 3.35 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:L144 | R:R:Y148 | 3.52 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:D147 | R:R:Y529 | 4.6 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:D147 | R:R:Y533 | 6.9 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | L:L:?1 | R:R:D147 | 3.47 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W199 | R:R:Y148 | 15.43 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:I222 | R:R:Y148 | 9.67 | 1 | No | Yes | 8 | 9 | 2 | 1 | L:L:?1 | R:R:Y148 | 21.71 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:S151 | 12.46 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:N152 | R:R:S195 | 8.94 | 1 | No | No | 9 | 9 | 1 | 2 | R:R:N152 | R:R:W199 | 11.3 | 1 | No | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:N152 | 3.51 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:F499 | R:R:V155 | 3.93 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:V155 | R:R:W503 | 3.68 | 1 | No | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W199 | 5.09 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F239 | R:R:F499 | 5.36 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F239 | R:R:W503 | 8.02 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F239 | R:R:N507 | 26.58 | 1 | Yes | No | 9 | 9 | 2 | 1 | R:R:N507 | R:R:Y240 | 3.49 | 0 | No | No | 9 | 8 | 1 | 2 | R:R:F499 | R:R:W503 | 17.04 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F499 | R:R:N535 | 9.67 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:T502 | R:R:W503 | 4.85 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:N535 | R:R:T502 | 10.24 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:C532 | R:R:W503 | 14.37 | 1 | No | Yes | 9 | 9 | 1 | 1 | R:R:N535 | R:R:W503 | 12.43 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W503 | 11.64 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:M509 | R:R:Y506 | 3.59 | 1 | No | Yes | 7 | 9 | 2 | 1 | R:R:W525 | R:R:Y506 | 7.72 | 1 | Yes | Yes | 5 | 9 | 2 | 1 | R:R:Y506 | R:R:Y529 | 8.94 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:C532 | R:R:Y506 | 4.03 | 1 | No | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:Y506 | 10.48 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:N507 | 8.77 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:M509 | R:R:W525 | 11.63 | 1 | No | Yes | 7 | 5 | 2 | 2 | R:R:Y529 | R:R:Y533 | 10.92 | 1 | Yes | Yes | 7 | 9 | 1 | 2 | L:L:?1 | R:R:Y529 | 8.98 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:C532 | 5.07 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:A238 | 3.02 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:G528 | R:R:Y506 | 2.9 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:V510 | R:R:Y506 | 2.52 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:T234 | R:R:W199 | 2.43 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 8.56 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 48.00 | Average Links Mediated by Hubs In Shell | 45.00 |
| ![](/psngpcr/ligands/0HK/0HK_4U14_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_4U14_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4U15 | A | Amine | Acetylcholine (muscarinic) | M3 | Rattus norvegicus | Tiotropium | - | - | 2.8 | 2014-11-26 | 10.1016/j.str.2014.08.022 |
![](/psngpcr/ligands/0HK/0HK_4U15_L_L_1.png)
A 2D representation of the interactions of 0HK in 4U15 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I116 | R:R:S120 | 6.19 | 1 | No | No | 9 | 9 | 2 | 2 | R:R:I116 | R:R:Y533 | 6.04 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:D147 | R:R:S120 | 11.78 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:S120 | R:R:Y533 | 7.63 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:M121 | R:R:W530 | 8.14 | 1 | No | Yes | 9 | 8 | 2 | 2 | R:R:M121 | R:R:Y533 | 8.38 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:F124 | R:R:W143 | 7.02 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:F124 | R:R:Y529 | 17.54 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F124 | R:R:W530 | 5.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F124 | R:R:Y533 | 6.19 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:D147 | R:R:W143 | 4.47 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | R:R:D147 | R:R:Y529 | 6.9 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:D147 | R:R:Y533 | 11.49 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:D147 | 4.33 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W199 | R:R:Y148 | 13.5 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:I222 | R:R:Y148 | 9.67 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:Y148 | R:R:Y529 | 3.97 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:Y148 | 20.96 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:S151 | 7.67 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:N152 | R:R:S195 | 8.94 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:N152 | R:R:W199 | 7.91 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:N152 | 5.26 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F499 | R:R:V155 | 3.93 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:V155 | R:R:W503 | 3.68 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:F224 | R:R:W199 | 4.01 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W199 | 3.64 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F224 | R:R:I222 | 3.77 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | L:L:?1 | R:R:T234 | 3.77 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:A238 | 5.03 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:F239 | R:R:Y240 | 12.38 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:F239 | R:R:F499 | 4.29 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F239 | R:R:W503 | 5.01 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F239 | R:R:N507 | 27.79 | 1 | Yes | No | 9 | 9 | 2 | 1 | R:R:N507 | R:R:Y240 | 4.65 | 1 | No | Yes | 9 | 8 | 1 | 2 | R:R:F499 | R:R:W503 | 20.04 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F499 | R:R:N535 | 4.83 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:T502 | R:R:W503 | 4.85 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:N535 | R:R:T502 | 5.85 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:C532 | R:R:W503 | 14.37 | 1 | No | Yes | 9 | 9 | 1 | 1 | R:R:N535 | R:R:W503 | 4.52 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W503 | 16 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W525 | R:R:Y506 | 8.68 | 0 | Yes | Yes | 5 | 9 | 2 | 1 | R:R:Y506 | R:R:Y529 | 8.94 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:Y506 | 9.73 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:N507 | 9.65 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:Y529 | R:R:Y533 | 9.93 | 1 | Yes | Yes | 7 | 9 | 1 | 1 | L:L:?1 | R:R:Y529 | 16.47 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:W530 | R:R:Y533 | 6.75 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | L:L:?1 | R:R:C532 | 8.11 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:Y533 | 3.74 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:G528 | R:R:Y506 | 2.9 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:M156 | R:R:N152 | 2.8 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:V149 | R:R:W199 | 2.45 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 8.80 | Average Nodes In Shell | 33.00 | Average Hubs In Shell | 20.00 | Average Links In Shell | 53.00 | Average Links Mediated by Hubs In Shell | 52.00 |
| ![](/psngpcr/ligands/0HK/0HK_4U15_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_4U15_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5CXV | A | Amine | Acetylcholine (muscarinic) | M1 | Homo sapiens | Tiotropium | - | - | 2.7 | 2016-03-09 | 10.1038/nature17188 |
![](/psngpcr/ligands/0HK/0HK_5CXV_L_L_1.png)
A 2D representation of the interactions of 0HK in 5CXV colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I74 | R:R:S78 | 7.74 | 1 | Yes | No | 8 | 8 | 2 | 2 | R:R:I74 | R:R:Y408 | 4.84 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:D105 | R:R:S78 | 11.78 | 1 | Yes | No | 9 | 8 | 1 | 2 | R:R:S78 | R:R:Y408 | 3.82 | 1 | No | Yes | 8 | 8 | 2 | 1 | R:R:M79 | R:R:Y408 | 13.17 | 0 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:Y404 | R:R:Y82 | 19.86 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:Y408 | R:R:Y82 | 7.94 | 1 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:D105 | R:R:Y404 | 4.6 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:D105 | R:R:Y408 | 10.34 | 1 | Yes | Yes | 9 | 8 | 1 | 1 | L:L:?1 | R:R:D105 | 4.33 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W157 | R:R:Y106 | 15.43 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | R:R:I161 | R:R:Y106 | 3.63 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:I180 | R:R:Y106 | 8.46 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:Y106 | R:R:Y404 | 4.96 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y106 | 20.96 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:S109 | R:R:W378 | 6.18 | 1 | No | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:S109 | 9.59 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:Q110 | R:R:V113 | 4.3 | 1 | Yes | No | 8 | 9 | 1 | 2 | R:R:Q110 | R:R:S153 | 5.78 | 1 | Yes | No | 8 | 8 | 1 | 2 | R:R:Q110 | R:R:W157 | 8.76 | 1 | Yes | Yes | 8 | 8 | 1 | 1 | R:R:A196 | R:R:Q110 | 4.55 | 1 | No | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:Q110 | 5.1 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:V113 | R:R:W378 | 3.68 | 0 | No | Yes | 9 | 8 | 2 | 1 | R:R:I161 | R:R:W157 | 3.52 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | L:L:?1 | R:R:W157 | 8 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I161 | R:R:I180 | 5.89 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I180 | R:R:L183 | 7.14 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:L183 | R:R:T192 | 4.42 | 1 | Yes | No | 7 | 8 | 2 | 1 | L:L:?1 | R:R:T192 | 4.71 | 1 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:A196 | 4.02 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:F197 | R:R:F374 | 5.36 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F197 | R:R:W378 | 7.02 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F197 | R:R:N382 | 22.96 | 1 | Yes | No | 9 | 8 | 2 | 1 | R:R:N382 | R:R:Y198 | 5.81 | 0 | No | No | 8 | 7 | 1 | 2 | R:R:F374 | R:R:W378 | 17.04 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | R:R:F374 | R:R:N410 | 3.62 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:T377 | R:R:W378 | 3.64 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:N410 | R:R:T377 | 5.85 | 1 | No | Yes | 9 | 8 | 2 | 2 | R:R:C407 | R:R:W378 | 11.75 | 1 | No | Yes | 8 | 8 | 1 | 1 | R:R:N410 | R:R:W378 | 7.91 | 1 | No | Yes | 9 | 8 | 2 | 1 | L:L:?1 | R:R:W378 | 10.91 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:W400 | R:R:Y381 | 6.75 | 1 | Yes | No | 7 | 8 | 2 | 1 | R:R:Y381 | R:R:Y404 | 7.94 | 1 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y381 | 14.22 | 1 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:N382 | 10.52 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:Y404 | R:R:Y408 | 6.95 | 1 | Yes | Yes | 7 | 8 | 1 | 1 | L:L:?1 | R:R:Y404 | 16.47 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:C407 | 6.08 | 1 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:Y408 | 4.49 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:L156 | R:R:W157 | 3.42 | 0 | No | Yes | 8 | 8 | 2 | 1 | L:L:?1 | R:R:A193 | 2.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.67 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 50.00 |
| ![](/psngpcr/ligands/0HK/0HK_5CXV_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_5CXV_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5DSG | A | Amine | Acetylcholine (muscarinic) | M4 | Homo sapiens | Tiotropium | - | - | 2.6 | 2016-03-16 | 10.1038/nature17188 |
![](/psngpcr/ligands/0HK/0HK_5DSG_L_L_1.png)
A 2D representation of the interactions of 0HK in 5DSG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I81 | R:R:S85 | 7.74 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:I81 | R:R:Y443 | 4.84 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:D112 | R:R:S85 | 10.31 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:S85 | R:R:Y443 | 7.63 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:M86 | R:R:W440 | 8.14 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:M86 | R:R:Y443 | 4.79 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:Y439 | R:R:Y89 | 17.87 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:W440 | R:R:Y89 | 4.82 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:Y443 | R:R:Y89 | 5.96 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:D112 | R:R:Y439 | 5.75 | 1 | Yes | Yes | 9 | 7 | 2 | 1 | R:R:D112 | R:R:Y443 | 6.9 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:W164 | R:R:Y113 | 14.47 | 1 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:I187 | R:R:Y113 | 10.88 | 0 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:Y113 | R:R:Y439 | 4.96 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:Y113 | 20.21 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:S116 | R:R:W413 | 4.94 | 1 | No | Yes | 8 | 9 | 1 | 1 | L:L:?1 | R:R:S116 | 7.67 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:N117 | R:R:W164 | 10.17 | 0 | No | Yes | 9 | 8 | 2 | 1 | R:R:I168 | R:R:W164 | 4.7 | 0 | No | Yes | 8 | 8 | 2 | 1 | L:L:?1 | R:R:W164 | 8.73 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I168 | R:R:I187 | 4.42 | 0 | No | Yes | 8 | 7 | 2 | 2 | L:L:?1 | R:R:A203 | 5.03 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:F204 | R:R:F409 | 4.29 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F204 | R:R:W413 | 6.01 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F204 | R:R:N417 | 24.17 | 1 | Yes | No | 9 | 9 | 2 | 1 | R:R:F409 | R:R:W413 | 19.04 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F409 | R:R:N445 | 4.83 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:T412 | R:R:W413 | 4.85 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:N445 | R:R:T412 | 7.31 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:C442 | R:R:W413 | 11.75 | 1 | No | Yes | 9 | 9 | 1 | 1 | R:R:N445 | R:R:W413 | 4.52 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W413 | 13.09 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:V420 | R:R:Y416 | 3.79 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:W435 | R:R:Y416 | 6.75 | 1 | Yes | Yes | 6 | 9 | 2 | 1 | R:R:Y416 | R:R:Y439 | 8.94 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | R:R:C442 | R:R:Y416 | 4.03 | 1 | No | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:Y416 | 12.73 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:N417 | 11.4 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:Y439 | R:R:Y443 | 8.94 | 1 | Yes | Yes | 7 | 9 | 1 | 1 | L:L:?1 | R:R:Y439 | 17.97 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:W440 | R:R:Y443 | 6.75 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:C442 | 7.09 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?1 | R:R:Y443 | 5.99 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?1 | R:R:A200 | 3.02 | 1 | Yes | No | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 10.27 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 44.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/0HK/0HK_5DSG_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_5DSG_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6OL9 | A | Amine | Acetylcholine (muscarinic) | M5 | Homo sapiens | Tiotropium | - | - | 2.54 | 2019-12-11 | 10.1073/pnas.1914446116 |
![](/psngpcr/ligands/0HK/0HK_6OL9_L_L_3.png)
A 2D representation of the interactions of 0HK in 6OL9 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I79 | R:R:S83 | 7.74 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:I79 | R:R:Y485 | 6.04 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:D110 | R:R:S83 | 10.31 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:S83 | R:R:Y485 | 7.63 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:M84 | R:R:W482 | 8.14 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:M84 | R:R:Y485 | 4.79 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:W106 | R:R:Y87 | 7.72 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:Y481 | R:R:Y87 | 18.86 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:Y485 | R:R:Y87 | 7.94 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:D110 | R:R:W106 | 15.63 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:D110 | R:R:Y481 | 5.75 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:D110 | R:R:Y485 | 10.34 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?3 | R:R:D110 | 3.47 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W162 | R:R:Y111 | 12.54 | 1 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:I166 | R:R:Y111 | 3.63 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:I185 | R:R:Y111 | 8.46 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:L188 | R:R:Y111 | 3.52 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:Y111 | R:R:Y481 | 5.96 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?3 | R:R:Y111 | 21.71 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:S114 | R:R:W455 | 4.94 | 1 | No | Yes | 9 | 9 | 1 | 1 | L:L:?3 | R:R:S114 | 8.63 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:M119 | R:R:N115 | 5.61 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:N115 | R:R:S158 | 8.94 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:N115 | R:R:W162 | 10.17 | 1 | Yes | Yes | 9 | 8 | 1 | 1 | L:L:?3 | R:R:N115 | 3.51 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F187 | R:R:W162 | 4.01 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | L:L:?3 | R:R:W162 | 3.64 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I166 | R:R:I185 | 7.36 | 1 | No | Yes | 9 | 9 | 2 | 2 | R:R:F187 | R:R:I185 | 6.28 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:I185 | R:R:L188 | 9.99 | 1 | Yes | Yes | 9 | 7 | 2 | 2 | R:R:F187 | R:R:L188 | 6.09 | 1 | Yes | Yes | 9 | 7 | 2 | 2 | R:R:L188 | R:R:T197 | 4.42 | 1 | Yes | No | 7 | 9 | 2 | 1 | L:L:?3 | R:R:T197 | 5.65 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:F202 | R:R:Y203 | 10.32 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:F202 | R:R:F451 | 4.29 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F202 | R:R:W455 | 4.01 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F202 | R:R:N459 | 26.58 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:N459 | R:R:Y203 | 3.49 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:F451 | R:R:W455 | 19.04 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F451 | R:R:N487 | 6.04 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:T454 | R:R:W455 | 4.85 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:N487 | R:R:T454 | 8.77 | 1 | Yes | No | 9 | 9 | 2 | 2 | R:R:C484 | R:R:W455 | 13.06 | 1 | No | Yes | 9 | 9 | 1 | 1 | R:R:N487 | R:R:W455 | 7.91 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?3 | R:R:W455 | 15.27 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:N459 | R:R:Y458 | 3.49 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:W477 | R:R:Y458 | 5.79 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | R:R:Y458 | R:R:Y481 | 4.96 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?3 | R:R:Y458 | 17.97 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?3 | R:R:N459 | 10.52 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:Y481 | R:R:Y485 | 9.93 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?3 | R:R:Y481 | 15.72 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W482 | R:R:Y485 | 5.79 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | L:L:?3 | R:R:C484 | 6.08 | 1 | Yes | No | 0 | 9 | 0 | 1 | L:L:?3 | R:R:Y485 | 3.74 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | L:L:?3 | R:R:A201 | 3.02 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:G480 | R:R:Y458 | 2.9 | 0 | No | Yes | 8 | 9 | 2 | 1 | R:R:I193 | R:R:T197 | 1.52 | 0 | No | No | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 9.15 | Average Nodes In Shell | 34.00 | Average Hubs In Shell | 23.00 | Average Links In Shell | 58.00 | Average Links Mediated by Hubs In Shell | 57.00 |
| ![](/psngpcr/ligands/0HK/0HK_6OL9_L_L_3_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/0HK/0HK_6OL9_L_L_3_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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