Code1WE
NameDextroamphetamine
Synonyms(+)-α-methylphenethylamine
Identifier(2S)-1-phenylpropan-2-amine
FormulaC9 H13 N
Molecular Weight135.206
SMILESC[C@@H](Cc1ccccc1)N
PubChem5826
Formal Charge0
Total Atoms23
Total Chiral Atoms1
Total Bonds23
Total Aromatic Bonds6
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JSO A Amine Trace amine receptors TA1 Homo Sapiens AMPH - chim(NtGi1-Gs)/Beta1/Gamma2 3.4 2023-11-15 10.1038/s41586-023-06804-z

A 2D representation of the interactions of 1WE in 8JSO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V76 7.3 0 No No 6 7 1 2
R:R:D103 R:R:Y294 5.75 0 No Yes 6 7 1 2
L:L:?1 R:R:D103 8.94 10 Yes No 0 6 0 1
R:R:A155 R:R:I104 3.25 0 No No 6 4 2 1
R:R:I104 R:R:I159 2.94 0 No Yes 4 6 1 2
L:L:?1 R:R:I104 4.03 10 Yes No 0 4 0 1
R:R:S107 R:R:W264 4.94 0 No Yes 6 8 1 2
L:L:?1 R:R:S107 8.48 10 Yes No 0 6 0 1
R:R:P151 R:R:S108 5.34 0 No No 8 5 2 1
R:R:S108 R:R:S198 4.89 0 No No 5 6 1 2
L:L:?1 R:R:S108 2.83 10 Yes No 0 5 0 1
R:R:F186 R:R:G191 4.52 0 Yes No 1 4 1 2
R:R:F186 R:R:T194 10.38 0 Yes No 1 5 1 2
L:L:?1 R:R:F186 3.44 10 Yes Yes 0 1 0 1
R:R:F195 R:R:F199 4.29 10 Yes Yes 5 8 2 2
R:R:F195 R:R:F268 4.29 10 Yes Yes 5 7 2 1
R:R:F199 R:R:W264 3.01 10 Yes Yes 8 8 2 2
R:R:F199 R:R:F268 19.29 10 Yes Yes 8 7 2 1
R:R:F267 R:R:W264 3.01 10 Yes Yes 5 8 1 2
R:R:F268 R:R:W264 8.02 10 Yes Yes 7 8 1 2
R:R:F267 R:R:F268 3.22 10 Yes Yes 5 7 1 1
R:R:F267 R:R:T271 7.78 10 Yes No 5 5 1 2
R:R:F267 R:R:L289 12.18 10 Yes No 5 5 1 2
L:L:?1 R:R:F267 11.47 10 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 9.17 10 Yes Yes 0 7 0 1
L:L:?1 R:R:I290 2.69 10 Yes No 0 5 0 1
R:R:F186 R:R:V184 2.62 0 Yes No 1 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.38
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.38
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell23.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)