| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7C7S | C | Aminoacid | GABAB | GABAB1; GABAB2 | Homo Sapiens | CGP54626 | - | - | 2.9 | 2020-07-01 | doi.org/10.1038/s41422-020-0350-5 |
|
A 2D representation of the interactions of 2BV in 7C7S
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:G184 | R:R:W182 | 9.85 | 0 | No | Yes | 5 | 6 | 2 | 1 | | R:R:G268 | R:R:W182 | 2.81 | 0 | No | Yes | 7 | 6 | 2 | 1 | | R:R:G463 | R:R:W182 | 2.81 | 0 | No | Yes | 4 | 6 | 2 | 1 | | R:R:E466 | R:R:W182 | 11.99 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | | L:L:?1006 | R:R:W182 | 10.62 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:S247 | R:R:S269 | 3.26 | 0 | No | Yes | 9 | 8 | 1 | 2 | | R:R:S247 | R:R:S271 | 4.89 | 0 | No | No | 9 | 9 | 1 | 2 | | L:L:?1006 | R:R:S247 | 5.39 | 1 | Yes | No | 0 | 9 | 0 | 1 | | R:R:G268 | R:R:H287 | 4.77 | 0 | No | Yes | 7 | 7 | 2 | 1 | | R:R:H287 | R:R:S270 | 5.58 | 1 | Yes | No | 7 | 7 | 1 | 1 | | L:L:?1006 | R:R:S270 | 9.7 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:H287 | R:R:P288 | 6.1 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | | R:R:H287 | R:R:M429 | 3.94 | 1 | Yes | No | 7 | 4 | 1 | 2 | | R:R:E466 | R:R:H287 | 4.92 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:H287 | R:R:L469 | 3.86 | 1 | Yes | No | 7 | 6 | 1 | 2 | | L:L:?1006 | R:R:H287 | 13.84 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:Q314 | R:R:Y367 | 4.51 | 1 | No | Yes | 8 | 7 | 2 | 1 | | R:R:E370 | R:R:Q314 | 19.11 | 1 | Yes | No | 5 | 8 | 2 | 2 | | R:R:F319 | R:R:Y367 | 12.38 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | | R:R:E370 | R:R:Y367 | 4.49 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | | R:R:W395 | R:R:Y367 | 4.82 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | | L:L:?1006 | R:R:Y367 | 3.36 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:I393 | R:R:W395 | 10.57 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:I393 | R:R:Y396 | 4.84 | 1 | No | Yes | 5 | 5 | 2 | 2 | | R:R:W395 | R:R:Y396 | 4.82 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | L:L:?1006 | R:R:W395 | 26.15 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:E466 | R:R:M429 | 4.06 | 1 | Yes | No | 5 | 4 | 1 | 2 | | R:R:L469 | R:R:M429 | 5.65 | 1 | No | No | 6 | 4 | 2 | 2 | | L:L:?1006 | R:R:E466 | 8.56 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:C246 | R:R:W182 | 2.61 | 1 | No | Yes | 7 | 6 | 2 | 1 | | R:R:E466 | R:R:Q465 | 2.55 | 1 | Yes | No | 5 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 11.09 | | Average Nodes In Shell | 23.00 | | Average Hubs In Shell | 11.00 | | Average Links In Shell | 31.00 | | Average Links Mediated by Hubs In Shell | 29.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7CUM | C | Aminoacid | GABAB | GABAB1; GABAB2 | Homo Sapiens | CGP54626 | - | - | 3.52 | 2020-11-11 | doi.org/10.1016/j.jmb.2020.09.023 |
|
A 2D representation of the interactions of 2BV in 7CUM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:P177 | R:R:W182 | 2.7 | 0 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:C220 | R:R:P177 | 3.77 | 0 | No | Yes | 8 | 7 | 2 | 2 | | R:R:G180 | R:R:G181 | 2.11 | 0 | No | No | 3 | 5 | 2 | 1 | | L:L:?1001 | R:R:G181 | 3.68 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:G184 | R:R:W182 | 8.44 | 0 | No | Yes | 5 | 6 | 2 | 1 | | R:R:C246 | R:R:W182 | 2.61 | 1 | No | Yes | 7 | 6 | 1 | 1 | | R:R:E466 | R:R:W182 | 11.99 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | | L:L:?1001 | R:R:W182 | 29.42 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | R:R:C220 | R:R:C246 | 7.28 | 0 | No | No | 8 | 7 | 2 | 1 | | L:L:?1001 | R:R:C246 | 3.42 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:S247 | R:R:S271 | 6.52 | 0 | No | No | 9 | 9 | 1 | 2 | | L:L:?1001 | R:R:S247 | 4.31 | 1 | Yes | No | 0 | 9 | 0 | 1 | | R:R:G268 | R:R:H287 | 4.77 | 0 | No | Yes | 7 | 7 | 2 | 1 | | R:R:H287 | R:R:S270 | 4.18 | 1 | Yes | No | 7 | 7 | 1 | 1 | | L:L:?1001 | R:R:S270 | 7.54 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:H287 | R:R:P288 | 6.1 | 1 | Yes | No | 7 | 6 | 1 | 2 | | R:R:E466 | R:R:H287 | 3.69 | 1 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:H287 | R:R:L469 | 3.86 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | | L:L:?1001 | R:R:H287 | 3.69 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:W395 | R:R:Y367 | 2.89 | 1 | Yes | No | 5 | 7 | 1 | 2 | | R:R:I393 | R:R:W395 | 8.22 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:I393 | R:R:Y396 | 8.46 | 1 | No | Yes | 5 | 5 | 2 | 2 | | R:R:W395 | R:R:Y396 | 2.89 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | L:L:?1001 | R:R:W395 | 12.26 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1001 | R:R:E466 | 8.56 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:E466 | R:R:Q465 | 1.27 | 1 | Yes | No | 5 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 9.11 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9JQX | C | Aminoacid | GABAB | GABAB1; GABAB2 | Drosophila melanogaster | CGP54626 | - | - | 3.61 | 2025-10-01 | To be published |
|
A 2D representation of the interactions of 2BV in 9JQX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:W51 | 20.43 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:S116 | 7.54 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:S139 | 7.54 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:H156 | 11.07 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:Y236 | 6.73 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:W264 | 13.89 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:E343 | 7.61 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | R:R:G53 | R:R:W51 | 11.26 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:W51 | R:R:Y136 | 2.89 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | | R:R:G340 | R:R:W51 | 4.22 | 0 | No | Yes | 3 | 5 | 2 | 1 | | R:R:E343 | R:R:W51 | 14.17 | 1 | Yes | Yes | 5 | 5 | 1 | 1 | | R:R:S116 | R:R:S140 | 4.89 | 0 | No | Yes | 8 | 8 | 1 | 2 | | R:R:G137 | R:R:H156 | 4.77 | 0 | No | Yes | 7 | 6 | 2 | 1 | | R:R:H156 | R:R:S139 | 6.97 | 1 | Yes | No | 6 | 7 | 1 | 1 | | R:R:H156 | R:R:P157 | 6.1 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:E343 | R:R:H156 | 6.15 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | | R:R:H156 | R:R:L346 | 6.43 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | | R:R:L346 | R:R:P157 | 3.28 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | | R:R:H162 | R:R:W264 | 3.17 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:F188 | R:R:Q183 | 5.86 | 1 | Yes | Yes | 6 | 8 | 2 | 2 | | R:R:Q183 | R:R:Y236 | 5.64 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F188 | R:R:Y236 | 16.5 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | R:R:W264 | R:R:Y236 | 3.86 | 1 | Yes | Yes | 4 | 7 | 1 | 1 | | R:R:I262 | R:R:W264 | 12.92 | 1 | No | Yes | 4 | 4 | 2 | 1 | | R:R:I262 | R:R:Y265 | 8.46 | 1 | No | Yes | 4 | 6 | 2 | 2 | | R:R:W264 | R:R:Y265 | 4.82 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | | R:R:E343 | R:R:M300 | 5.41 | 1 | Yes | No | 5 | 5 | 1 | 2 | | R:R:L346 | R:R:M300 | 5.65 | 1 | Yes | No | 6 | 5 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 10.69 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 14.00 | | Average Links In Shell | 28.00 | | Average Links Mediated by Hubs In Shell | 28.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
