Code3HR
Name(3R)-3-hydroxybutanoic acid
Synonyms
Identifier(3R)-3-oxidanylbutanoic acid
FormulaC4 H8 O3
Molecular Weight104.105
SMILESC[C@H](CC(=O)O)O
PubChem92135
Formal Charge0
Total Atoms15
Total Chiral Atoms1
Total Bonds14
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J6Q A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens Beta-hydroxybutyrate Compound 9n Gi1/Beta1/Gamma2 2.6 2023-12-06 10.1038/s41467-023-43537-z

A 2D representation of the interactions of 3HR in 8J6Q
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E37 R:R:L34 3.98 1 Yes Yes 7 8 2 2
R:R:L34 R:R:Y284 3.52 1 Yes Yes 8 7 2 1
R:R:E37 R:R:Y284 4.49 1 Yes Yes 7 7 2 1
R:R:L107 R:R:L76 4.15 1 Yes No 6 7 1 2
R:R:L76 R:R:Y284 4.69 1 No Yes 7 7 2 1
R:R:C79 R:R:L107 3.17 0 No Yes 6 6 2 1
R:R:L80 R:R:Y284 7.03 0 No Yes 8 7 2 1
R:R:L83 R:R:M103 5.65 1 Yes Yes 6 5 2 2
R:R:L107 R:R:L83 6.92 1 Yes Yes 6 6 1 2
R:R:L83 R:R:Y284 3.52 1 Yes Yes 6 7 2 1
R:R:C100 R:R:L104 3.17 1 Yes Yes 9 5 2 1
R:R:C100 R:R:M167 4.86 1 Yes No 9 3 2 2
R:R:C100 R:R:C177 7.28 1 Yes Yes 9 9 2 2
R:R:L107 R:R:M103 5.65 1 Yes Yes 6 5 1 2
R:R:L104 R:R:M167 4.24 1 Yes No 5 3 1 2
R:R:C177 R:R:L104 4.76 1 Yes Yes 9 5 2 1
R:R:L104 R:R:S179 7.51 1 Yes Yes 5 4 1 1
L:L:?1 R:R:L104 3.69 1 Yes Yes 0 5 0 1
R:R:L107 R:R:Y284 5.86 1 Yes Yes 6 7 1 1
L:L:?1 R:R:L107 6.16 1 Yes Yes 0 6 0 1
R:R:F180 R:R:R111 5.34 1 Yes Yes 3 8 1 1
R:R:F193 R:R:R111 3.21 1 Yes Yes 6 8 2 1
R:R:E196 R:R:R111 9.3 1 Yes Yes 5 8 2 1
R:R:R111 R:R:T283 6.47 1 Yes No 8 8 1 2
L:L:?1 R:R:R111 9.72 1 Yes Yes 0 8 0 1
R:R:F180 R:R:S179 3.96 1 Yes Yes 3 4 1 1
R:R:H189 R:R:S179 5.58 1 Yes Yes 5 4 2 1
L:L:?1 R:R:S179 9.35 1 Yes Yes 0 4 0 1
R:R:F180 R:R:H189 9.05 1 Yes Yes 3 5 1 2
R:R:E190 R:R:F180 4.66 1 Yes Yes 4 3 2 1
R:R:F180 R:R:F193 12.86 1 Yes Yes 3 6 1 2
R:R:F180 R:R:R251 4.28 1 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 15 1 Yes Yes 3 4 1 2
R:R:F180 R:R:L280 3.65 1 Yes Yes 3 5 1 1
L:L:?1 R:R:F180 10.83 1 Yes Yes 0 3 0 1
R:R:E190 R:R:R251 10.47 1 Yes Yes 4 5 2 2
R:R:E196 R:R:F193 3.5 1 Yes Yes 5 6 2 2
R:R:F193 R:R:R251 3.21 1 Yes Yes 6 5 2 2
R:R:F193 R:R:F276 5.36 1 Yes Yes 6 4 2 2
R:R:F276 R:R:R251 19.24 1 Yes Yes 4 5 2 2
R:R:F276 R:R:L280 3.65 1 Yes Yes 4 5 2 1
R:R:L280 R:R:Y284 3.52 1 Yes Yes 5 7 1 1
L:L:?1 R:R:L280 6.16 1 Yes Yes 0 5 0 1
R:R:T283 R:R:Y284 3.75 0 No Yes 8 7 2 1
L:L:?1 R:R:Y284 6.26 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.45
Average Nodes In Shell25.00
Average Hubs In Shell20.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.45
Average Nodes In Shell25.00
Average Hubs In Shell20.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell45.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)