Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6W25 | A | Peptide | Melanocortin | MC4 | Homo Sapiens | SHU9119 | Ca | - | 2.75 | 2020-04-29 | 10.1126/science.aaz8995 |

A 2D representation of the interactions of 4J2 in 6W25 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | L:L:R5 | 6.82 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W6 | 8.22 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:L97 | 5.55 | 1 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:E100 | 13.81 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:D126 | 15.23 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:I129 | 18.31 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?4 | R:R:C130 | 6.36 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:F261 | 13.67 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:L288 | 5.55 | 1 | Yes | No | 0 | 4 | 0 | 1 | I:I:?1 | L:L:?4 | 10.2 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:R5 | L:L:W6 | 15.99 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:R5 | R:R:N123 | 6.03 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:R5 | R:R:D126 | 19.06 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:R5 | R:R:I185 | 7.52 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:R5 | R:R:S188 | 10.54 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W6 | R:R:I194 | 8.22 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W6 | R:R:L265 | 9.11 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W6 | R:R:Y268 | 12.54 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:F51 | R:R:L288 | 4.87 | 5 | Yes | No | 6 | 4 | 2 | 1 | R:R:I129 | R:R:S96 | 4.64 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:L97 | R:R:M292 | 5.65 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:E100 | R:R:I125 | 9.56 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 6.5 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | I:I:?1 | R:R:E100 | 9.74 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | R:R:D122 | R:R:D126 | 10.65 | 1 | No | Yes | 8 | 4 | 2 | 1 | I:I:?1 | R:R:D122 | 7.49 | 1 | Yes | No | 0 | 8 | 1 | 2 | I:I:?1 | R:R:D126 | 7.49 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:C130 | R:R:I185 | 4.91 | 0 | Yes | No | 4 | 5 | 1 | 2 | R:R:F261 | R:R:W258 | 7.02 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:F262 | R:R:W258 | 8.02 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:I291 | R:R:W258 | 17.62 | 1 | No | Yes | 6 | 7 | 2 | 2 | R:R:F261 | R:R:F262 | 7.5 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:F261 | R:R:L265 | 8.53 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 5.36 | 1 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F261 | R:R:I291 | 7.54 | 1 | Yes | No | 5 | 6 | 1 | 2 | R:R:F284 | R:R:L288 | 12.18 | 0 | Yes | No | 3 | 4 | 2 | 1 | R:R:C130 | R:R:F184 | 4.19 | 0 | Yes | Yes | 4 | 4 | 1 | 2 | R:R:C130 | R:R:G181 | 3.92 | 0 | Yes | No | 4 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 10.37 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 36.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F4I | A | Peptide | Melanocortin | MC1 | Homo Sapiens | SHU9119 | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.1 | 2021-09-08 | 10.1038/s41422-021-00557-y |

A 2D representation of the interactions of 4J2 in 7F4I colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F45 | R:R:L284 | 7.31 | 0 | No | No | 6 | 4 | 2 | 1 | R:R:M128 | R:R:V87 | 4.56 | 5 | Yes | No | 5 | 8 | 1 | 2 | R:R:E94 | R:R:I98 | 4.1 | 5 | Yes | Yes | 4 | 3 | 1 | 2 | R:R:D121 | R:R:E94 | 5.2 | 5 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?4 | R:R:E94 | 11 | 5 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D117 | R:R:D121 | 9.31 | 0 | No | Yes | 6 | 5 | 2 | 1 | L:L:?4 | R:R:D121 | 9.02 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R5 | R:R:D121 | 13.1 | 5 | Yes | Yes | 0 | 5 | 1 | 1 | R:R:C125 | R:R:S176 | 6.89 | 0 | No | No | 4 | 7 | 1 | 2 | L:L:?4 | R:R:C125 | 7.91 | 5 | Yes | No | 0 | 4 | 0 | 1 | R:R:M128 | R:R:W254 | 6.98 | 5 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:I287 | R:R:M128 | 7.29 | 5 | No | Yes | 7 | 5 | 2 | 1 | L:L:?4 | R:R:M128 | 4.7 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:R5 | R:R:I180 | 6.26 | 5 | Yes | No | 0 | 5 | 1 | 2 | L:L:R5 | R:R:Y183 | 16.46 | 5 | Yes | No | 0 | 3 | 1 | 2 | L:L:W6 | R:R:Y183 | 3.86 | 5 | Yes | No | 0 | 3 | 1 | 2 | L:L:W6 | R:R:L189 | 15.94 | 5 | Yes | No | 0 | 4 | 1 | 2 | R:R:I287 | R:R:W254 | 9.4 | 5 | No | Yes | 7 | 7 | 2 | 2 | R:R:F257 | R:R:F258 | 6.43 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:F257 | R:R:L261 | 9.74 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:F257 | R:R:F280 | 5.36 | 0 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:F257 | R:R:I287 | 5.02 | 0 | Yes | No | 5 | 7 | 1 | 2 | L:L:?4 | R:R:F257 | 11.12 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:W6 | R:R:L261 | 5.69 | 5 | Yes | No | 0 | 5 | 1 | 2 | R:R:F280 | R:R:L284 | 7.31 | 0 | Yes | No | 4 | 4 | 2 | 1 | L:L:?4 | R:R:L284 | 4.6 | 5 | Yes | No | 0 | 4 | 0 | 1 | L:L:?4 | L:L:R5 | 11.1 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W6 | 3.78 | 5 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:R5 | L:L:W6 | 5 | 5 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:W6 | R:R:L192 | 3.42 | 5 | Yes | No | 0 | 5 | 1 | 2 | R:R:E94 | R:R:I120 | 2.73 | 5 | Yes | No | 4 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.90 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 29.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IOD | A | Peptide | Melanocortin | MC5 | Homo Sapiens | PG-901 | Ca | chim(NtGi1-Gs)/Beta1/Gamma2 | 2.59 | 2023-09-20 | 10.1038/s41421-023-00586-4 |

A 2D representation of the interactions of 4J2 in 8IOD colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | L:L:R5 | 11.69 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W6 | 6.39 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:E92 | 6.37 | 4 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?4 | R:R:D119 | 8.7 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:I122 | 17.17 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:V126 | 5.97 | 4 | Yes | No | 0 | 6 | 0 | 1 | L:L:?4 | R:R:F254 | 11.72 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:L281 | 4.44 | 4 | Yes | No | 0 | 3 | 0 | 1 | I:I:?1 | L:L:?4 | 8.16 | 4 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:R5 | L:L:W6 | 4 | 4 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:R5 | R:R:N116 | 4.82 | 4 | Yes | No | 0 | 4 | 1 | 2 | L:L:R5 | R:R:D119 | 19.06 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:R5 | R:R:I178 | 7.52 | 4 | Yes | Yes | 0 | 4 | 1 | 2 | L:L:R5 | R:R:S181 | 9.22 | 4 | Yes | No | 0 | 2 | 1 | 2 | I:I:?1 | L:L:R5 | 4.47 | 4 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:W6 | R:R:S181 | 6.18 | 4 | Yes | No | 0 | 2 | 1 | 2 | L:L:W6 | R:R:I187 | 10.57 | 4 | Yes | No | 0 | 5 | 1 | 2 | L:L:W6 | R:R:L258 | 4.56 | 4 | Yes | No | 0 | 4 | 1 | 2 | R:R:F43 | R:R:L281 | 4.87 | 24 | Yes | No | 6 | 3 | 2 | 1 | R:R:V126 | R:R:V85 | 4.81 | 0 | No | No | 6 | 8 | 1 | 2 | R:R:I122 | R:R:S88 | 9.29 | 4 | Yes | No | 5 | 6 | 1 | 2 | R:R:I122 | R:R:S89 | 9.29 | 4 | Yes | No | 5 | 6 | 1 | 2 | R:R:E92 | R:R:I96 | 4.1 | 4 | Yes | Yes | 6 | 4 | 1 | 2 | R:R:D115 | R:R:E92 | 3.9 | 4 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:E92 | R:R:F118 | 7 | 4 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:D119 | R:R:E92 | 9.09 | 4 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:E92 | R:R:I122 | 4.1 | 4 | Yes | Yes | 6 | 5 | 1 | 1 | I:I:?1 | R:R:E92 | 7.31 | 4 | Yes | Yes | 0 | 6 | 1 | 1 | R:R:D115 | R:R:D119 | 11.98 | 4 | Yes | Yes | 8 | 4 | 2 | 1 | I:I:?1 | R:R:D115 | 7.49 | 4 | Yes | Yes | 0 | 8 | 1 | 2 | R:R:I178 | R:R:N116 | 4.25 | 4 | Yes | No | 4 | 4 | 2 | 2 | R:R:D119 | R:R:I178 | 4.2 | 4 | Yes | Yes | 4 | 4 | 1 | 2 | I:I:?1 | R:R:D119 | 7.49 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | R:R:F254 | R:R:F255 | 4.29 | 0 | Yes | No | 5 | 5 | 1 | 2 | R:R:F254 | R:R:L258 | 9.74 | 0 | Yes | No | 5 | 4 | 1 | 2 | R:R:F254 | R:R:F277 | 6.43 | 0 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:F254 | R:R:I284 | 6.28 | 0 | Yes | No | 5 | 7 | 1 | 2 | R:R:F277 | R:R:L281 | 14.61 | 0 | Yes | No | 4 | 3 | 2 | 1 | L:L:W6 | R:R:M261 | 3.49 | 4 | Yes | No | 0 | 4 | 1 | 2 | L:L:W6 | R:R:L190 | 3.42 | 4 | Yes | No | 0 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 8.96 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 40.00 | Average Links Mediated by Hubs In Shell | 39.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8KIG | A | Peptide | Melanocortin | MC3 | Homo Sapiens | SHU9119 | Ca | - | 3.1 | 2025-02-26 | 10.2210/pdb8KIG/pdb |

A 2D representation of the interactions of 4J2 in 8KIG colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | I:I:?1 | L:L:?4 | 8.16 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | I:I:?1 | R:R:E94 | 7.31 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | I:I:?1 | R:R:D117 | 7.49 | 1 | Yes | Yes | 0 | 3 | 1 | 2 | I:I:?1 | R:R:D121 | 9.98 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?4 | L:L:H3 | 3.09 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:H3 | R:R:F45 | 5.66 | 1 | Yes | No | 0 | 7 | 1 | 2 | L:L:H3 | R:R:T95 | 5.48 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:H3 | R:R:I98 | 5.3 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?4 | L:L:R5 | 5.84 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | L:L:W6 | 3.65 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?4 | R:R:E94 | 4.25 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?4 | R:R:D121 | 7.62 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:I124 | 9.15 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?4 | R:R:F258 | 5.86 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?4 | R:R:L285 | 4.44 | 1 | Yes | No | 0 | 3 | 0 | 1 | L:L:R5 | L:L:W6 | 17.99 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:R5 | R:R:N118 | 4.82 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:R5 | R:R:D121 | 13.1 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:R5 | R:R:I180 | 8.77 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R5 | R:R:S183 | 9.22 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W6 | R:R:V188 | 3.68 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W6 | R:R:I189 | 9.4 | 1 | Yes | No | 0 | 6 | 1 | 2 | R:R:F45 | R:R:T95 | 6.49 | 1 | No | No | 7 | 5 | 2 | 2 | R:R:I124 | R:R:S90 | 7.74 | 0 | No | No | 4 | 5 | 1 | 2 | R:R:I124 | R:R:N91 | 2.83 | 0 | No | No | 4 | 6 | 1 | 2 | R:R:D117 | R:R:E94 | 3.9 | 1 | Yes | Yes | 3 | 5 | 2 | 1 | R:R:E94 | R:R:F120 | 8.16 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:D121 | R:R:E94 | 6.5 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:D117 | R:R:D121 | 10.65 | 1 | Yes | Yes | 3 | 4 | 2 | 1 | R:R:I180 | R:R:N118 | 2.83 | 1 | Yes | No | 5 | 4 | 2 | 2 | R:R:I189 | R:R:L262 | 4.28 | 0 | No | Yes | 6 | 5 | 2 | 2 | R:R:F258 | R:R:L262 | 6.09 | 0 | No | Yes | 5 | 5 | 1 | 2 | R:R:F258 | R:R:F281 | 5.36 | 0 | No | Yes | 5 | 3 | 1 | 2 | R:R:F281 | R:R:L285 | 4.87 | 0 | Yes | No | 3 | 3 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 5.78 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 31.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WKY | A | Peptide | Melanocortin | MC4 | Homo sapiens | PG-934 | - | - | 2.9 | 2024-08-07 | doi.org/10.1021/acs.jmedchem.3c01822 |

A 2D representation of the interactions of 4J2 in 8WKY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?5 | L:L:R6 | 6.82 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | L:L:W7 | 5.48 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | R:R:E100 | 11.69 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?5 | R:R:D126 | 13.06 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:I129 | 17.17 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?5 | R:R:C130 | 6.36 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:F261 | 7.81 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?5 | R:R:L288 | 4.44 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:R6 | L:L:W7 | 14.99 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:R6 | R:R:D122 | 4.76 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:R6 | R:R:D126 | 17.87 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:R6 | R:R:I185 | 8.77 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:R6 | R:R:S188 | 13.18 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:S188 | 4.94 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:I194 | 5.87 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:L265 | 7.97 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W7 | R:R:Y268 | 7.72 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:F51 | R:R:L288 | 3.65 | 0 | Yes | No | 6 | 4 | 2 | 1 | R:R:I129 | R:R:S96 | 4.64 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:E100 | R:R:I125 | 8.2 | 1 | No | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 5.2 | 1 | Yes | No | 4 | 5 | 1 | 1 | R:R:D122 | R:R:D126 | 9.31 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | R:R:D126 | R:R:I185 | 4.2 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:C130 | R:R:G181 | 3.92 | 0 | Yes | No | 4 | 6 | 1 | 2 | R:R:C130 | R:R:F184 | 4.19 | 0 | Yes | Yes | 4 | 4 | 1 | 2 | R:R:C130 | R:R:I185 | 4.91 | 0 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:I194 | R:R:L265 | 5.71 | 1 | No | No | 4 | 5 | 2 | 2 | R:R:F261 | R:R:W258 | 5.01 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:I291 | R:R:W258 | 18.79 | 1 | No | Yes | 6 | 7 | 2 | 2 | R:R:F261 | R:R:L265 | 4.87 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 4.29 | 1 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F261 | R:R:I291 | 6.28 | 1 | Yes | No | 5 | 6 | 1 | 2 | R:R:F284 | R:R:L288 | 8.53 | 0 | Yes | No | 3 | 4 | 2 | 1 | L:L:R6 | R:R:N123 | 3.62 | 1 | Yes | No | 0 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.10 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 31.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WKZ | A | Peptide | Melanocortin | MC4 | Homo sapiens | SBL-MC-31 | - | - | 3.3 | 2024-08-07 | doi.org/10.1021/acs.jmedchem.3c01822 |

A 2D representation of the interactions of 4J2 in 8WKZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?5 | L:L:R6 | 10.71 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | L:L:W7 | 8.22 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | R:R:E100 | 11.69 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?5 | R:R:D126 | 15.23 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:I129 | 18.31 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?5 | R:R:C130 | 6.36 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?5 | R:R:F261 | 8.79 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?5 | R:R:L288 | 3.33 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:R6 | L:L:W7 | 4 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:R6 | R:R:D122 | 4.76 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:R6 | R:R:N123 | 3.62 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:R6 | R:R:D126 | 17.87 | 1 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:R6 | R:R:I185 | 10.02 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:R6 | R:R:S188 | 9.22 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:S188 | 3.71 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:I194 | 7.05 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:W7 | R:R:F261 | 4.01 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:W7 | R:R:L265 | 12.53 | 1 | Yes | No | 0 | 5 | 1 | 2 | L:L:W7 | R:R:Y268 | 9.65 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:I129 | R:R:S96 | 4.64 | 0 | No | No | 5 | 6 | 1 | 2 | R:R:I129 | R:R:L97 | 4.28 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:L288 | R:R:L97 | 4.15 | 0 | No | Yes | 4 | 6 | 1 | 2 | R:R:E100 | R:R:I104 | 4.1 | 1 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:E100 | R:R:I125 | 8.2 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:D126 | R:R:E100 | 6.5 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:D122 | R:R:D126 | 10.65 | 1 | Yes | Yes | 8 | 4 | 2 | 1 | R:R:C130 | R:R:G181 | 3.92 | 0 | Yes | No | 4 | 6 | 1 | 2 | R:R:C130 | R:R:F184 | 4.19 | 0 | Yes | Yes | 4 | 4 | 1 | 2 | R:R:C130 | R:R:I185 | 4.91 | 0 | Yes | No | 4 | 5 | 1 | 2 | R:R:I194 | R:R:L265 | 4.28 | 1 | No | No | 4 | 5 | 2 | 2 | R:R:F261 | R:R:W258 | 5.01 | 1 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:F262 | R:R:W258 | 7.02 | 1 | No | Yes | 5 | 7 | 2 | 2 | R:R:I291 | R:R:W258 | 23.49 | 1 | No | Yes | 6 | 7 | 2 | 2 | R:R:F261 | R:R:F262 | 7.5 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:F261 | R:R:F284 | 4.29 | 1 | Yes | Yes | 5 | 3 | 1 | 2 | R:R:F261 | R:R:I291 | 5.02 | 1 | Yes | No | 5 | 6 | 1 | 2 | R:R:F284 | R:R:L288 | 8.53 | 0 | Yes | No | 3 | 4 | 2 | 1 | |
Statistics | Value |
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Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 10.33 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 37.00 | Average Links Mediated by Hubs In Shell | 35.00 |
|  Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) |  Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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