Code4J2
Name(2R)-2-amino-3-(naphthalen-2-yl)propanoic acid
Synonyms
Identifier
FormulaC13 H13 N O2
Molecular Weight215.248
SMILES
PubChem2733661
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds11
Networks8
missing image

This ligand is also present in the following 8 networks:

Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W25 A Peptide Melanocortin MC4 Homo Sapiens SHU9119 Ca - 2.75 2020-04-29 10.1126/science.aaz8995

A 2D representation of the interactions of 4J2 in 6W25
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:R5 6.82 1 Yes Yes 0 0 0 1
L:L:?4 L:L:W6 8.22 1 Yes Yes 0 0 0 1
L:L:?4 R:R:L97 5.55 1 Yes No 0 6 0 1
L:L:?4 R:R:E100 13.81 1 Yes Yes 0 5 0 1
L:L:?4 R:R:D126 15.23 1 Yes Yes 0 4 0 1
L:L:?4 R:R:I129 18.31 1 Yes No 0 5 0 1
L:L:?4 R:R:C130 6.36 1 Yes Yes 0 4 0 1
L:L:?4 R:R:F261 13.67 1 Yes Yes 0 5 0 1
L:L:?4 R:R:L288 5.55 1 Yes No 0 4 0 1
I:I:?1 L:L:?4 10.2 1 Yes Yes 0 0 1 0
L:L:R5 L:L:W6 15.99 1 Yes Yes 0 0 1 1
L:L:R5 R:R:N123 6.03 1 Yes No 0 5 1 2
L:L:R5 R:R:D126 19.06 1 Yes Yes 0 4 1 1
L:L:R5 R:R:I185 7.52 1 Yes No 0 5 1 2
L:L:R5 R:R:S188 10.54 1 Yes No 0 4 1 2
L:L:W6 R:R:I194 8.22 1 Yes No 0 4 1 2
L:L:W6 R:R:L265 9.11 1 Yes No 0 5 1 2
L:L:W6 R:R:Y268 12.54 1 Yes No 0 5 1 2
R:R:F51 R:R:L288 4.87 5 Yes No 6 4 2 1
R:R:I129 R:R:S96 4.64 0 No No 5 6 1 2
R:R:L97 R:R:M292 5.65 0 No No 6 5 1 2
R:R:E100 R:R:I125 9.56 1 Yes No 5 5 1 2
R:R:D126 R:R:E100 6.5 1 Yes Yes 4 5 1 1
I:I:?1 R:R:E100 9.74 1 Yes Yes 0 5 1 1
R:R:D122 R:R:D126 10.65 1 No Yes 8 4 2 1
I:I:?1 R:R:D122 7.49 1 Yes No 0 8 1 2
I:I:?1 R:R:D126 7.49 1 Yes Yes 0 4 1 1
R:R:C130 R:R:I185 4.91 0 Yes No 4 5 1 2
R:R:F261 R:R:W258 7.02 1 Yes Yes 5 7 1 2
R:R:F262 R:R:W258 8.02 1 Yes Yes 5 7 2 2
R:R:I291 R:R:W258 17.62 1 No Yes 6 7 2 2
R:R:F261 R:R:F262 7.5 1 Yes Yes 5 5 1 2
R:R:F261 R:R:L265 8.53 1 Yes No 5 5 1 2
R:R:F261 R:R:F284 5.36 1 Yes Yes 5 3 1 2
R:R:F261 R:R:I291 7.54 1 Yes No 5 6 1 2
R:R:F284 R:R:L288 12.18 0 Yes No 3 4 2 1
R:R:C130 R:R:F184 4.19 0 Yes Yes 4 4 1 2
R:R:C130 R:R:G181 3.92 0 Yes No 4 6 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.37
Average Nodes In Shell28.00
Average Hubs In Shell13.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4I A Peptide Melanocortin MC1 Homo Sapiens SHU9119 - chim(NtGi1-Gs)/Beta1/Gamma2 3.1 2021-09-08 10.1038/s41422-021-00557-y

A 2D representation of the interactions of 4J2 in 7F4I
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F45 R:R:L284 7.31 0 No No 6 4 2 1
R:R:M128 R:R:V87 4.56 5 Yes No 5 8 1 2
R:R:E94 R:R:I98 4.1 5 Yes Yes 4 3 1 2
R:R:D121 R:R:E94 5.2 5 Yes Yes 5 4 1 1
L:L:?4 R:R:E94 11 5 Yes Yes 0 4 0 1
R:R:D117 R:R:D121 9.31 0 No Yes 6 5 2 1
L:L:?4 R:R:D121 9.02 5 Yes Yes 0 5 0 1
L:L:R5 R:R:D121 13.1 5 Yes Yes 0 5 1 1
R:R:C125 R:R:S176 6.89 0 No No 4 7 1 2
L:L:?4 R:R:C125 7.91 5 Yes No 0 4 0 1
R:R:M128 R:R:W254 6.98 5 Yes Yes 5 7 1 2
R:R:I287 R:R:M128 7.29 5 No Yes 7 5 2 1
L:L:?4 R:R:M128 4.7 5 Yes Yes 0 5 0 1
L:L:R5 R:R:I180 6.26 5 Yes No 0 5 1 2
L:L:R5 R:R:Y183 16.46 5 Yes No 0 3 1 2
L:L:W6 R:R:Y183 3.86 5 Yes No 0 3 1 2
L:L:W6 R:R:L189 15.94 5 Yes No 0 4 1 2
R:R:I287 R:R:W254 9.4 5 No Yes 7 7 2 2
R:R:F257 R:R:F258 6.43 0 Yes No 5 5 1 2
R:R:F257 R:R:L261 9.74 0 Yes No 5 5 1 2
R:R:F257 R:R:F280 5.36 0 Yes Yes 5 4 1 2
R:R:F257 R:R:I287 5.02 0 Yes No 5 7 1 2
L:L:?4 R:R:F257 11.12 5 Yes Yes 0 5 0 1
L:L:W6 R:R:L261 5.69 5 Yes No 0 5 1 2
R:R:F280 R:R:L284 7.31 0 Yes No 4 4 2 1
L:L:?4 R:R:L284 4.6 5 Yes No 0 4 0 1
L:L:?4 L:L:R5 11.1 5 Yes Yes 0 0 0 1
L:L:?4 L:L:W6 3.78 5 Yes Yes 0 0 0 1
L:L:R5 L:L:W6 5 5 Yes Yes 0 0 1 1
L:L:W6 R:R:L192 3.42 5 Yes No 0 5 1 2
R:R:E94 R:R:I120 2.73 5 Yes No 4 5 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.90
Average Nodes In Shell24.00
Average Hubs In Shell10.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IOD A Peptide Melanocortin MC5 Homo Sapiens PG-901 Ca chim(NtGi1-Gs)/Beta1/Gamma2 2.59 2023-09-20 10.1038/s41421-023-00586-4

A 2D representation of the interactions of 4J2 in 8IOD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:R5 11.69 4 Yes Yes 0 0 0 1
L:L:?4 L:L:W6 6.39 4 Yes Yes 0 0 0 1
L:L:?4 R:R:E92 6.37 4 Yes Yes 0 6 0 1
L:L:?4 R:R:D119 8.7 4 Yes Yes 0 4 0 1
L:L:?4 R:R:I122 17.17 4 Yes Yes 0 5 0 1
L:L:?4 R:R:V126 5.97 4 Yes No 0 6 0 1
L:L:?4 R:R:F254 11.72 4 Yes Yes 0 5 0 1
L:L:?4 R:R:L281 4.44 4 Yes No 0 3 0 1
I:I:?1 L:L:?4 8.16 4 Yes Yes 0 0 1 0
L:L:R5 L:L:W6 4 4 Yes Yes 0 0 1 1
L:L:R5 R:R:N116 4.82 4 Yes No 0 4 1 2
L:L:R5 R:R:D119 19.06 4 Yes Yes 0 4 1 1
L:L:R5 R:R:I178 7.52 4 Yes Yes 0 4 1 2
L:L:R5 R:R:S181 9.22 4 Yes No 0 2 1 2
I:I:?1 L:L:R5 4.47 4 Yes Yes 0 0 1 1
L:L:W6 R:R:S181 6.18 4 Yes No 0 2 1 2
L:L:W6 R:R:I187 10.57 4 Yes No 0 5 1 2
L:L:W6 R:R:L258 4.56 4 Yes No 0 4 1 2
R:R:F43 R:R:L281 4.87 24 Yes No 6 3 2 1
R:R:V126 R:R:V85 4.81 0 No No 6 8 1 2
R:R:I122 R:R:S88 9.29 4 Yes No 5 6 1 2
R:R:I122 R:R:S89 9.29 4 Yes No 5 6 1 2
R:R:E92 R:R:I96 4.1 4 Yes Yes 6 4 1 2
R:R:D115 R:R:E92 3.9 4 Yes Yes 8 6 2 1
R:R:E92 R:R:F118 7 4 Yes Yes 6 6 1 2
R:R:D119 R:R:E92 9.09 4 Yes Yes 4 6 1 1
R:R:E92 R:R:I122 4.1 4 Yes Yes 6 5 1 1
I:I:?1 R:R:E92 7.31 4 Yes Yes 0 6 1 1
R:R:D115 R:R:D119 11.98 4 Yes Yes 8 4 2 1
I:I:?1 R:R:D115 7.49 4 Yes Yes 0 8 1 2
R:R:I178 R:R:N116 4.25 4 Yes No 4 4 2 2
R:R:D119 R:R:I178 4.2 4 Yes Yes 4 4 1 2
I:I:?1 R:R:D119 7.49 4 Yes Yes 0 4 1 1
R:R:F254 R:R:F255 4.29 0 Yes No 5 5 1 2
R:R:F254 R:R:L258 9.74 0 Yes No 5 4 1 2
R:R:F254 R:R:F277 6.43 0 Yes Yes 5 4 1 2
R:R:F254 R:R:I284 6.28 0 Yes No 5 7 1 2
R:R:F277 R:R:L281 14.61 0 Yes No 4 3 2 1
L:L:W6 R:R:M261 3.49 4 Yes No 0 4 1 2
L:L:W6 R:R:L190 3.42 4 Yes No 0 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.96
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KIG A Peptide Melanocortin MC3 Homo Sapiens SHU9119 Ca - 3.1 2025-02-26 10.2210/pdb8KIG/pdb

A 2D representation of the interactions of 4J2 in 8KIG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
I:I:?1 L:L:?4 8.16 1 Yes Yes 0 0 1 0
I:I:?1 R:R:E94 7.31 1 Yes Yes 0 5 1 1
I:I:?1 R:R:D117 7.49 1 Yes Yes 0 3 1 2
I:I:?1 R:R:D121 9.98 1 Yes Yes 0 4 1 1
L:L:?4 L:L:H3 3.09 1 Yes Yes 0 0 0 1
L:L:H3 R:R:F45 5.66 1 Yes No 0 7 1 2
L:L:H3 R:R:T95 5.48 1 Yes No 0 5 1 2
L:L:H3 R:R:I98 5.3 1 Yes No 0 4 1 2
L:L:?4 L:L:R5 5.84 1 Yes Yes 0 0 0 1
L:L:?4 L:L:W6 3.65 1 Yes Yes 0 0 0 1
L:L:?4 R:R:E94 4.25 1 Yes Yes 0 5 0 1
L:L:?4 R:R:D121 7.62 1 Yes Yes 0 4 0 1
L:L:?4 R:R:I124 9.15 1 Yes No 0 4 0 1
L:L:?4 R:R:F258 5.86 1 Yes No 0 5 0 1
L:L:?4 R:R:L285 4.44 1 Yes No 0 3 0 1
L:L:R5 L:L:W6 17.99 1 Yes Yes 0 0 1 1
L:L:R5 R:R:N118 4.82 1 Yes No 0 4 1 2
L:L:R5 R:R:D121 13.1 1 Yes Yes 0 4 1 1
L:L:R5 R:R:I180 8.77 1 Yes Yes 0 5 1 2
L:L:R5 R:R:S183 9.22 1 Yes No 0 5 1 2
L:L:W6 R:R:V188 3.68 1 Yes No 0 5 1 2
L:L:W6 R:R:I189 9.4 1 Yes No 0 6 1 2
R:R:F45 R:R:T95 6.49 1 No No 7 5 2 2
R:R:I124 R:R:S90 7.74 0 No No 4 5 1 2
R:R:I124 R:R:N91 2.83 0 No No 4 6 1 2
R:R:D117 R:R:E94 3.9 1 Yes Yes 3 5 2 1
R:R:E94 R:R:F120 8.16 1 Yes No 5 5 1 2
R:R:D121 R:R:E94 6.5 1 Yes Yes 4 5 1 1
R:R:D117 R:R:D121 10.65 1 Yes Yes 3 4 2 1
R:R:I180 R:R:N118 2.83 1 Yes No 5 4 2 2
R:R:I189 R:R:L262 4.28 0 No Yes 6 5 2 2
R:R:F258 R:R:L262 6.09 0 No Yes 5 5 1 2
R:R:F258 R:R:F281 5.36 0 No Yes 5 3 1 2
R:R:F281 R:R:L285 4.87 0 Yes No 3 3 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.78
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WKY A Peptide Melanocortin MC4 Homo sapiens PG-934 - - 2.9 2024-08-07 doi.org/10.1021/acs.jmedchem.3c01822

A 2D representation of the interactions of 4J2 in 8WKY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?5 L:L:R6 6.82 1 Yes Yes 0 0 0 1
L:L:?5 L:L:W7 5.48 1 Yes Yes 0 0 0 1
L:L:?5 R:R:E100 11.69 1 Yes No 0 5 0 1
L:L:?5 R:R:D126 13.06 1 Yes Yes 0 4 0 1
L:L:?5 R:R:I129 17.17 1 Yes No 0 5 0 1
L:L:?5 R:R:C130 6.36 1 Yes Yes 0 4 0 1
L:L:?5 R:R:F261 7.81 1 Yes Yes 0 5 0 1
L:L:?5 R:R:L288 4.44 1 Yes No 0 4 0 1
L:L:R6 L:L:W7 14.99 1 Yes Yes 0 0 1 1
L:L:R6 R:R:D122 4.76 1 Yes Yes 0 8 1 2
L:L:R6 R:R:D126 17.87 1 Yes Yes 0 4 1 1
L:L:R6 R:R:I185 8.77 1 Yes Yes 0 5 1 2
L:L:R6 R:R:S188 13.18 1 Yes No 0 4 1 2
L:L:W7 R:R:S188 4.94 1 Yes No 0 4 1 2
L:L:W7 R:R:I194 5.87 1 Yes No 0 4 1 2
L:L:W7 R:R:L265 7.97 1 Yes No 0 5 1 2
L:L:W7 R:R:Y268 7.72 1 Yes No 0 5 1 2
R:R:F51 R:R:L288 3.65 0 Yes No 6 4 2 1
R:R:I129 R:R:S96 4.64 0 No No 5 6 1 2
R:R:E100 R:R:I125 8.2 1 No No 5 5 1 2
R:R:D126 R:R:E100 5.2 1 Yes No 4 5 1 1
R:R:D122 R:R:D126 9.31 1 Yes Yes 8 4 2 1
R:R:D126 R:R:I185 4.2 1 Yes Yes 4 5 1 2
R:R:C130 R:R:G181 3.92 0 Yes No 4 6 1 2
R:R:C130 R:R:F184 4.19 0 Yes Yes 4 4 1 2
R:R:C130 R:R:I185 4.91 0 Yes Yes 4 5 1 2
R:R:I194 R:R:L265 5.71 1 No No 4 5 2 2
R:R:F261 R:R:W258 5.01 1 Yes Yes 5 7 1 2
R:R:I291 R:R:W258 18.79 1 No Yes 6 7 2 2
R:R:F261 R:R:L265 4.87 1 Yes No 5 5 1 2
R:R:F261 R:R:F284 4.29 1 Yes Yes 5 3 1 2
R:R:F261 R:R:I291 6.28 1 Yes No 5 6 1 2
R:R:F284 R:R:L288 8.53 0 Yes No 3 4 2 1
L:L:R6 R:R:N123 3.62 1 Yes No 0 5 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.10
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WKZ A Peptide Melanocortin MC4 Homo sapiens SBL-MC-31 - - 3.3 2024-08-07 doi.org/10.1021/acs.jmedchem.3c01822

A 2D representation of the interactions of 4J2 in 8WKZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?5 L:L:R6 10.71 1 Yes Yes 0 0 0 1
L:L:?5 L:L:W7 8.22 1 Yes Yes 0 0 0 1
L:L:?5 R:R:E100 11.69 1 Yes Yes 0 5 0 1
L:L:?5 R:R:D126 15.23 1 Yes Yes 0 4 0 1
L:L:?5 R:R:I129 18.31 1 Yes No 0 5 0 1
L:L:?5 R:R:C130 6.36 1 Yes Yes 0 4 0 1
L:L:?5 R:R:F261 8.79 1 Yes Yes 0 5 0 1
L:L:?5 R:R:L288 3.33 1 Yes No 0 4 0 1
L:L:R6 L:L:W7 4 1 Yes Yes 0 0 1 1
L:L:R6 R:R:D122 4.76 1 Yes Yes 0 8 1 2
L:L:R6 R:R:N123 3.62 1 Yes No 0 5 1 2
L:L:R6 R:R:D126 17.87 1 Yes Yes 0 4 1 1
L:L:R6 R:R:I185 10.02 1 Yes No 0 5 1 2
L:L:R6 R:R:S188 9.22 1 Yes No 0 4 1 2
L:L:W7 R:R:S188 3.71 1 Yes No 0 4 1 2
L:L:W7 R:R:I194 7.05 1 Yes No 0 4 1 2
L:L:W7 R:R:F261 4.01 1 Yes Yes 0 5 1 1
L:L:W7 R:R:L265 12.53 1 Yes No 0 5 1 2
L:L:W7 R:R:Y268 9.65 1 Yes No 0 5 1 2
R:R:I129 R:R:S96 4.64 0 No No 5 6 1 2
R:R:I129 R:R:L97 4.28 0 No Yes 5 6 1 2
R:R:L288 R:R:L97 4.15 0 No Yes 4 6 1 2
R:R:E100 R:R:I104 4.1 1 Yes Yes 5 4 1 2
R:R:E100 R:R:I125 8.2 1 Yes No 5 5 1 2
R:R:D126 R:R:E100 6.5 1 Yes Yes 4 5 1 1
R:R:D122 R:R:D126 10.65 1 Yes Yes 8 4 2 1
R:R:C130 R:R:G181 3.92 0 Yes No 4 6 1 2
R:R:C130 R:R:F184 4.19 0 Yes Yes 4 4 1 2
R:R:C130 R:R:I185 4.91 0 Yes No 4 5 1 2
R:R:I194 R:R:L265 4.28 1 No No 4 5 2 2
R:R:F261 R:R:W258 5.01 1 Yes Yes 5 7 1 2
R:R:F262 R:R:W258 7.02 1 No Yes 5 7 2 2
R:R:I291 R:R:W258 23.49 1 No Yes 6 7 2 2
R:R:F261 R:R:F262 7.5 1 Yes No 5 5 1 2
R:R:F261 R:R:F284 4.29 1 Yes Yes 5 3 1 2
R:R:F261 R:R:I291 5.02 1 Yes No 5 6 1 2
R:R:F284 R:R:L288 8.53 0 Yes No 3 4 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.33
Average Nodes In Shell26.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell35.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.62
Average Number Of Links With An Hub6.12
Average Interaction Strength8.63
Average Nodes In Shell25.25
Average Hubs In Shell11.88
Average Links In Shell34.88
Average Links Mediated by Hubs In Shell32.62

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)