Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 2Y03 | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Isoprenaline | - | - | 2.85 | 2011-01-12 | 10.1038/nature09746 |
![](/psngpcr/ligands/5FW/5FW_2Y03_L_L_5.png)
A 2D representation of the interactions of 5FW in 2Y03 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 4.38 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 6.31 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 7.36 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 3.79 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 7.02 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 7.02 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 9.37 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:C199 | R:R:W107 | 13.06 | 1 | No | Yes | 9 | 7 | 2 | 2 | R:R:C199 | R:R:W117 | 3.92 | 1 | No | Yes | 9 | 6 | 2 | 1 | L:L:?5 | R:R:W117 | 4.63 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 6.49 | 1 | Yes | No | 4 | 6 | 1 | 1 | L:L:?5 | R:R:T118 | 3.6 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:D121 | R:R:Y333 | 9.2 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?5 | R:R:D121 | 22.08 | 1 | Yes | No | 0 | 7 | 0 | 1 | L:L:?5 | R:R:V122 | 14.54 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 17.16 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?5 | R:R:V125 | 3.63 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 6.4 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I177 | R:R:W182 | 8.22 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F201 | R:R:I177 | 5.02 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:I177 | R:R:Y207 | 4.84 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F201 | R:R:W182 | 8.02 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 1 | No | Yes | 4 | 5 | 2 | 2 | R:R:W182 | R:R:Y207 | 6.75 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 7.78 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F201 | R:R:Y207 | 5.16 | 1 | Yes | Yes | 4 | 7 | 1 | 2 | L:L:?5 | R:R:F201 | 11.89 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 4.99 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 11.45 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?5 | R:R:S211 | 7.33 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 2 | L:L:?5 | R:R:S215 | 4.88 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 30.01 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 10.72 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 6.43 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 12.08 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?5 | R:R:F306 | 9.91 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?5 | R:R:F307 | 9.91 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N329 | R:R:Y333 | 9.3 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?5 | R:R:N329 | 14.52 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 16.4 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?5 | R:R:Y333 | 3.81 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L101 | R:R:W117 | 2.28 | 0 | No | Yes | 5 | 6 | 2 | 1 | R:R:S215 | R:R:V172 | 1.62 | 0 | No | No | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.23 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 47.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/5FW/5FW_2Y03_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_2Y03_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6H7J | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Isoprenaline | - | - | 2.8 | 2018-10-17 | 10.1126/science.aau5595 |
![](/psngpcr/ligands/5FW/5FW_6H7J_L_L_1.png)
A 2D representation of the interactions of 5FW in 6H7J colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 7.3 | 1 | No | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 3.79 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:V95 | R:R:W330 | 4.9 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:V95 | R:R:Y333 | 5.05 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 5.01 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 8.02 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 15.93 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 4.63 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I177 | R:R:T118 | 6.08 | 1 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:T118 | 3.6 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:D121 | R:R:Y333 | 10.34 | 1 | No | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 24.28 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:V122 | R:R:Y207 | 3.79 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:V122 | 16.96 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 9.81 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V125 | 7.27 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:I177 | R:R:W182 | 14.09 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:I177 | R:R:Y207 | 4.84 | 1 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F201 | R:R:W182 | 4.01 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:T203 | R:R:W182 | 3.64 | 1 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:W182 | R:R:Y207 | 6.75 | 1 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 5.19 | 1 | Yes | Yes | 4 | 4 | 1 | 2 | R:R:F201 | R:R:N310 | 3.62 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:F201 | 10.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 6.24 | 1 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 10.17 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 8.55 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 5.28 | 1 | Yes | No | 7 | 6 | 1 | 2 | R:R:N310 | R:R:S212 | 4.47 | 1 | Yes | No | 6 | 6 | 1 | 2 | L:L:?1 | R:R:S215 | 7.33 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:F307 | 21.43 | 0 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 9.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 13.93 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:N310 | 7.25 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F306 | R:R:F325 | 5.36 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 14.5 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 10.9 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 11.89 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 6.04 | 1 | Yes | Yes | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N310 | 4.47 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 15.12 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 14.52 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 11.58 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 4.77 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S211 | R:R:V172 | 1.62 | 0 | No | No | 6 | 5 | 1 | 2 | R:R:S215 | R:R:V172 | 1.62 | 0 | No | No | 6 | 5 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 10.01 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 49.00 | Average Links Mediated by Hubs In Shell | 45.00 |
| ![](/psngpcr/ligands/5FW/5FW_6H7J_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_6H7J_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DHR | A | Amine | Adrenergic | Beta2 | Homo sapiens | Isoprenaline | - | Gs/Beta1/Gamma2 | 3.8 | 2020-12-16 | 10.1093/nsr/nwaa284 |
![](/psngpcr/ligands/5FW/5FW_7DHR_L_L_1.png)
A 2D representation of the interactions of 5FW in 7DHR colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:M82 | R:R:V86 | 3.04 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:M82 | R:R:Y316 | 5.99 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:D113 | R:R:V86 | 8.76 | 1 | No | Yes | 7 | 7 | 1 | 2 | R:R:V86 | R:R:Y316 | 5.05 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:D113 | R:R:Y316 | 9.2 | 1 | No | Yes | 7 | 6 | 1 | 1 | L:L:?1 | R:R:D113 | 17.66 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:V117 | R:R:W286 | 7.36 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V117 | 6.06 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S207 | R:R:T118 | 3.2 | 0 | No | Yes | 5 | 6 | 1 | 2 | R:R:F193 | R:R:Y174 | 3.09 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:Y174 | R:R:Y199 | 8.94 | 1 | Yes | Yes | 5 | 6 | 2 | 2 | R:R:F193 | R:R:T195 | 5.19 | 1 | Yes | Yes | 4 | 3 | 1 | 2 | R:R:F193 | R:R:Y199 | 4.13 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:F193 | R:R:Y308 | 5.16 | 1 | Yes | No | 4 | 5 | 1 | 2 | L:L:?1 | R:R:F193 | 10.9 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:T195 | R:R:Y199 | 6.24 | 1 | Yes | Yes | 3 | 6 | 2 | 2 | R:R:S203 | R:R:Y199 | 6.36 | 0 | No | Yes | 5 | 6 | 1 | 2 | L:L:?1 | R:R:S203 | 6.11 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:S207 | 7.33 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F208 | R:R:W286 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F208 | R:R:F290 | 12.86 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F290 | R:R:W286 | 10.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:W286 | R:R:Y316 | 2.89 | 1 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:F289 | R:R:N312 | 10.87 | 0 | Yes | No | 6 | 5 | 2 | 1 | R:R:F290 | R:R:N293 | 3.62 | 1 | Yes | Yes | 7 | 5 | 1 | 1 | L:L:?1 | R:R:F290 | 9.91 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N293 | R:R:V292 | 2.96 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:N293 | R:R:Y308 | 12.79 | 1 | Yes | No | 5 | 5 | 1 | 2 | R:R:N293 | R:R:N312 | 4.09 | 1 | Yes | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:N293 | 3.35 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:N312 | 4.47 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:W313 | R:R:Y316 | 9.65 | 0 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y316 | 2.86 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F193 | R:R:T110 | 2.59 | 1 | Yes | No | 4 | 4 | 1 | 2 | R:R:F290 | R:R:S204 | 1.32 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:D192 | R:R:F193 | 1.19 | 0 | No | Yes | 3 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 7.63 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 36.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/5FW/5FW_7DHR_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_7DHR_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7JJO | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Isoprenaline | - | Gs/Beta1/Gamma2 | 2.6 | 2020-09-02 | 10.1016/j.molcel.2020.08.001 |
![](/psngpcr/ligands/5FW/5FW_7JJO_L_L_401.png)
A 2D representation of the interactions of 5FW in 7JJO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 10.22 | 2 | Yes | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 5.05 | 2 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 5.01 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 5.01 | 2 | Yes | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 11.25 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | L:L:?401 | R:R:W117 | 4.63 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:I177 | R:R:T118 | 3.04 | 2 | Yes | No | 6 | 6 | 2 | 1 | L:L:?401 | R:R:T118 | 3.6 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:D121 | R:R:V125 | 4.38 | 2 | Yes | No | 7 | 6 | 1 | 1 | R:R:D121 | R:R:Y333 | 12.64 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?401 | R:R:D121 | 18.76 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 3.23 | 27 | No | No | 7 | 6 | 2 | 1 | L:L:?401 | R:R:V122 | 13.33 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 9.81 | 2 | No | Yes | 6 | 8 | 1 | 2 | L:L:?401 | R:R:V125 | 7.27 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 9.59 | 0 | No | Yes | 6 | 6 | 1 | 2 | R:R:I177 | R:R:Y207 | 4.84 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F201 | R:R:T203 | 3.89 | 2 | No | Yes | 4 | 4 | 1 | 2 | R:R:F201 | R:R:N310 | 4.83 | 2 | No | No | 4 | 6 | 1 | 1 | L:L:?401 | R:R:F201 | 21.79 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 3.75 | 2 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 7.63 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?401 | R:R:S211 | 9.77 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 3.96 | 2 | Yes | No | 7 | 6 | 1 | 2 | L:L:?401 | R:R:S215 | 4.88 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:W303 | 3.01 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F216 | R:R:F307 | 18.22 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 4.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 9.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 9.65 | 2 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 9.65 | 2 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 20.54 | 2 | Yes | No | 7 | 6 | 1 | 1 | L:L:?401 | R:R:F306 | 6.93 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?401 | R:R:F307 | 5.94 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 7.25 | 0 | No | No | 4 | 6 | 2 | 1 | L:L:?401 | R:R:N310 | 3.35 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 10.47 | 2 | No | Yes | 6 | 7 | 1 | 1 | L:L:?401 | R:R:N329 | 15.63 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 3.86 | 0 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?401 | R:R:Y333 | 5.72 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.35 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 41.00 | Average Links Mediated by Hubs In Shell | 38.00 |
| ![](/psngpcr/ligands/5FW/5FW_7JJO_L_L_401_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_7JJO_L_L_401_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7S0F | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Isoprenaline | - | Gi1/Beta1/Gamma2 | 2.96 | 2021-11-17 | 10.1038/s41594-021-00679-2 |
![](/psngpcr/ligands/5FW/5FW_7S0F_L_L_1.png)
A 2D representation of the interactions of 5FW in 7S0F colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D121 | R:R:V94 | 7.3 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 3.79 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W107 | 5.01 | 1 | No | Yes | 4 | 7 | 2 | 2 | R:R:F97 | R:R:W117 | 8.02 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 5.62 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:T118 | R:R:W117 | 3.64 | 0 | No | Yes | 6 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 6.48 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:D121 | R:R:V125 | 4.38 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:D121 | R:R:Y333 | 12.64 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 18.76 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 3.23 | 0 | No | No | 7 | 6 | 2 | 1 | R:R:I177 | R:R:V122 | 3.07 | 0 | Yes | No | 6 | 6 | 2 | 1 | L:L:?1 | R:R:V122 | 13.33 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:I129 | R:R:V125 | 3.07 | 1 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:V125 | R:R:W303 | 9.81 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V125 | 8.48 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S215 | R:R:T126 | 7.99 | 1 | No | No | 6 | 6 | 1 | 2 | R:R:I129 | R:R:W303 | 10.57 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:I177 | R:R:W182 | 3.52 | 0 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:I177 | R:R:Y207 | 4.84 | 0 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F201 | R:R:W182 | 5.01 | 0 | No | Yes | 4 | 5 | 1 | 2 | R:R:F201 | R:R:F325 | 3.22 | 0 | No | Yes | 4 | 4 | 1 | 2 | L:L:?1 | R:R:F201 | 17.83 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S211 | R:R:Y207 | 6.36 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 9.77 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 3.96 | 1 | Yes | No | 7 | 6 | 1 | 2 | R:R:N310 | R:R:S212 | 5.96 | 1 | Yes | No | 6 | 6 | 1 | 2 | R:R:F307 | R:R:S215 | 6.61 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:S215 | 3.66 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F216 | R:R:W303 | 5.01 | 1 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F216 | R:R:F307 | 19.29 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F306 | R:R:F307 | 12.86 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:N310 | 4.83 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F306 | R:R:F325 | 7.5 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 13.29 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 8.92 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 7.92 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F325 | R:R:N310 | 3.62 | 1 | Yes | Yes | 4 | 6 | 2 | 1 | L:L:?1 | R:R:N310 | 5.58 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 12.79 | 1 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 15.63 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 9.65 | 0 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 5.72 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 10.17 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 46.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/5FW/5FW_7S0F_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_7S0F_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7S0G | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Isoprenaline | - | chim(Gi1-CtGs)/Beta1/Gamma2 | 3.86 | 2021-11-17 | 10.1038/s41594-021-00679-2 |
![](/psngpcr/ligands/5FW/5FW_7S0G_L_L_1.png)
A 2D representation of the interactions of 5FW in 7S0G colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V94 | R:R:W117 | 6.13 | 4 | No | Yes | 7 | 6 | 2 | 1 | R:R:D121 | R:R:V94 | 5.84 | 4 | Yes | No | 7 | 7 | 1 | 2 | R:R:V94 | R:R:Y333 | 3.79 | 4 | No | Yes | 7 | 7 | 2 | 1 | R:R:F97 | R:R:W117 | 9.02 | 0 | No | Yes | 4 | 6 | 2 | 1 | R:R:G98 | R:R:W117 | 4.22 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:W107 | R:R:W117 | 14.99 | 4 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:C199 | R:R:W107 | 19.59 | 4 | No | Yes | 9 | 7 | 2 | 2 | R:R:C199 | R:R:W117 | 2.61 | 4 | No | Yes | 9 | 6 | 2 | 1 | L:L:?1 | R:R:W117 | 5.56 | 4 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F201 | R:R:T118 | 2.59 | 0 | No | No | 4 | 6 | 1 | 2 | R:R:D121 | R:R:V125 | 4.38 | 4 | Yes | No | 7 | 6 | 1 | 1 | R:R:D121 | R:R:Y333 | 11.49 | 4 | Yes | Yes | 7 | 7 | 1 | 1 | L:L:?1 | R:R:D121 | 22.08 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S173 | R:R:V122 | 3.23 | 22 | No | No | 7 | 6 | 2 | 1 | R:R:V122 | R:R:Y207 | 3.79 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:V122 | 10.9 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:V125 | R:R:W303 | 9.81 | 4 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:V125 | 6.06 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:I129 | R:R:W303 | 8.22 | 4 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F307 | R:R:I129 | 2.51 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F201 | R:R:T203 | 2.59 | 0 | No | Yes | 4 | 4 | 1 | 2 | L:L:?1 | R:R:F201 | 20.8 | 4 | Yes | No | 0 | 4 | 0 | 1 | R:R:T203 | R:R:Y207 | 4.99 | 9 | Yes | Yes | 4 | 7 | 2 | 2 | R:R:S211 | R:R:Y207 | 3.82 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S211 | 8.55 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:F307 | R:R:S212 | 5.28 | 4 | Yes | No | 7 | 6 | 1 | 2 | R:R:N310 | R:R:S212 | 2.98 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:F307 | R:R:S215 | 2.64 | 4 | Yes | No | 7 | 6 | 1 | 2 | R:R:F216 | R:R:W303 | 4.01 | 4 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:F216 | R:R:F307 | 18.22 | 4 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F306 | R:R:W303 | 6.01 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F307 | R:R:W303 | 5.01 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:W303 | R:R:Y333 | 2.89 | 4 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F306 | R:R:F307 | 5.36 | 4 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F306 | R:R:F325 | 11.79 | 4 | Yes | No | 7 | 4 | 1 | 2 | R:R:F306 | R:R:N329 | 13.29 | 4 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F306 | 7.92 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F307 | 4.95 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N310 | 4.47 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:N329 | R:R:Y333 | 16.28 | 4 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:N329 | 10.05 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:W330 | R:R:Y333 | 3.86 | 4 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:Y333 | 8.58 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 9.99 | Average Nodes In Shell | 28.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 40.00 |
| ![](/psngpcr/ligands/5FW/5FW_7S0G_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_7S0G_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XJH | A | Amine | Adrenergic | Beta3 | Canis lupus familiaris | Isoproterenol | - | Gs/Beta1/Gamma2 | 3.3 | 2022-05-04 | 10.1016/j.molcel.2021.06.024 |
![](/psngpcr/ligands/5FW/5FW_7XJH_L_L_1.png)
A 2D representation of the interactions of 5FW in 7XJH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V90 | R:R:W113 | 4.9 | 4 | No | Yes | 7 | 5 | 2 | 1 | R:R:D117 | R:R:V90 | 11.69 | 4 | Yes | No | 7 | 7 | 1 | 2 | R:R:V90 | R:R:Y336 | 5.05 | 4 | No | Yes | 7 | 7 | 2 | 2 | R:R:P93 | R:R:W113 | 8.11 | 0 | No | Yes | 5 | 5 | 2 | 1 | R:R:G94 | R:R:W113 | 5.63 | 0 | No | Yes | 7 | 5 | 2 | 1 | R:R:W103 | R:R:W113 | 10.31 | 4 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:C196 | R:R:W103 | 7.84 | 4 | No | Yes | 9 | 7 | 2 | 2 | R:R:C196 | R:R:W113 | 3.92 | 4 | No | Yes | 9 | 5 | 2 | 1 | L:L:?1 | R:R:W113 | 6.48 | 4 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T114 | 3.6 | 4 | Yes | No | 0 | 5 | 0 | 1 | R:R:D117 | R:R:V121 | 4.38 | 4 | Yes | No | 7 | 7 | 1 | 1 | R:R:D117 | R:R:Y336 | 10.34 | 4 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D117 | 20.97 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S169 | R:R:V118 | 6.46 | 0 | No | No | 7 | 7 | 2 | 1 | L:L:?1 | R:R:V118 | 9.69 | 4 | Yes | No | 0 | 7 | 0 | 1 | R:R:V121 | R:R:W305 | 8.58 | 4 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:V121 | 9.69 | 4 | Yes | No | 0 | 7 | 0 | 1 | R:R:S212 | R:R:T122 | 9.59 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:F198 | R:R:S200 | 7.93 | 0 | No | No | 5 | 4 | 1 | 2 | R:R:F198 | R:R:N312 | 9.67 | 0 | No | No | 5 | 7 | 1 | 2 | L:L:?1 | R:R:F198 | 12.88 | 4 | Yes | No | 0 | 5 | 0 | 1 | R:R:S200 | R:R:Y204 | 5.09 | 0 | No | Yes | 4 | 8 | 2 | 2 | R:R:S208 | R:R:Y204 | 7.63 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:S208 | 9.77 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:F309 | R:R:S209 | 5.28 | 4 | Yes | No | 7 | 7 | 1 | 2 | R:R:N312 | R:R:S209 | 4.47 | 0 | No | No | 7 | 7 | 2 | 2 | L:L:?1 | R:R:S212 | 7.33 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:F213 | R:R:F309 | 20.36 | 4 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F308 | R:R:W305 | 7.02 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F309 | R:R:W305 | 8.02 | 4 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F308 | R:R:F309 | 11.79 | 4 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F308 | R:R:N312 | 4.83 | 4 | Yes | No | 7 | 7 | 1 | 2 | R:R:F308 | R:R:L331 | 3.65 | 4 | Yes | No | 7 | 6 | 1 | 2 | R:R:F308 | R:R:N332 | 16.92 | 4 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:F308 | 6.93 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F309 | 5.94 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:N332 | R:R:Y336 | 5.81 | 4 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:N332 | 11.17 | 4 | Yes | No | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.50 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 33.00 |
| ![](/psngpcr/ligands/5FW/5FW_7XJH_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/5FW/5FW_7XJH_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|