Code5FW
NameISOPRENALINE
Synonyms
Identifier4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
FormulaC11 H17 N O3
Molecular Weight211.258
SMILESCC(C)NC[C@@H](c1ccc(c(c1)O)O)O
PubChem443372
Formal Charge0
Total Atoms32
Total Chiral Atoms1
Total Bonds32
Total Aromatic Bonds6
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2Y03 A Amine Adrenergic Beta1 Meleagris gallopavo Isoprenaline - - 2.85 2011-01-12 10.1038/nature09746

A 2D representation of the interactions of 5FW in 2Y03
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D121 R:R:V94 4.38 1 No No 7 7 1 2
R:R:V94 R:R:Y333 6.31 1 No Yes 7 7 2 1
R:R:V95 R:R:W330 7.36 1 Yes Yes 7 6 2 2
R:R:V95 R:R:Y333 3.79 1 Yes Yes 7 7 2 1
R:R:F97 R:R:W107 7.02 1 No Yes 4 7 2 2
R:R:F97 R:R:W117 7.02 1 No Yes 4 6 2 1
R:R:G98 R:R:W117 4.22 0 No Yes 6 6 2 1
R:R:W107 R:R:W117 9.37 1 Yes Yes 7 6 2 1
R:R:C199 R:R:W107 13.06 1 No Yes 9 7 2 2
R:R:C199 R:R:W117 3.92 1 No Yes 9 6 2 1
L:L:?5 R:R:W117 4.63 1 Yes Yes 0 6 0 1
R:R:F201 R:R:T118 6.49 1 Yes No 4 6 1 1
L:L:?5 R:R:T118 3.6 1 Yes No 0 6 0 1
R:R:D121 R:R:Y333 9.2 1 No Yes 7 7 1 1
L:L:?5 R:R:D121 22.08 1 Yes No 0 7 0 1
L:L:?5 R:R:V122 14.54 1 Yes No 0 6 0 1
R:R:V125 R:R:W303 17.16 0 No Yes 6 8 1 2
L:L:?5 R:R:V125 3.63 1 Yes No 0 6 0 1
R:R:S215 R:R:T126 6.4 0 No No 6 6 1 2
R:R:I177 R:R:W182 8.22 1 Yes Yes 6 5 2 2
R:R:F201 R:R:I177 5.02 1 Yes Yes 4 6 1 2
R:R:I177 R:R:Y207 4.84 1 Yes Yes 6 7 2 2
R:R:F201 R:R:W182 8.02 1 Yes Yes 4 5 1 2
R:R:T203 R:R:W182 3.64 1 No Yes 4 5 2 2
R:R:W182 R:R:Y207 6.75 1 Yes Yes 5 7 2 2
R:R:F201 R:R:T203 7.78 1 Yes No 4 4 1 2
R:R:F201 R:R:Y207 5.16 1 Yes Yes 4 7 1 2
L:L:?5 R:R:F201 11.89 1 Yes Yes 0 4 0 1
R:R:T203 R:R:Y207 4.99 1 No Yes 4 7 2 2
R:R:S211 R:R:Y207 11.45 0 No Yes 6 7 1 2
L:L:?5 R:R:S211 7.33 1 Yes No 0 6 0 1
R:R:F307 R:R:S212 5.28 1 Yes No 7 6 1 2
L:L:?5 R:R:S215 4.88 1 Yes No 0 6 0 1
R:R:F216 R:R:F307 30.01 0 No Yes 7 7 2 1
R:R:F306 R:R:W303 6.01 1 Yes Yes 7 8 1 2
R:R:F307 R:R:W303 6.01 1 Yes Yes 7 8 1 2
R:R:F306 R:R:F307 10.72 1 Yes Yes 7 7 1 1
R:R:F306 R:R:F325 6.43 1 Yes No 7 4 1 2
R:R:F306 R:R:N329 12.08 1 Yes No 7 6 1 1
L:L:?5 R:R:F306 9.91 1 Yes Yes 0 7 0 1
L:L:?5 R:R:F307 9.91 1 Yes Yes 0 7 0 1
R:R:N329 R:R:Y333 9.3 1 No Yes 6 7 1 1
L:L:?5 R:R:N329 14.52 1 Yes No 0 6 0 1
R:R:W330 R:R:Y333 16.4 1 Yes Yes 6 7 2 1
L:L:?5 R:R:Y333 3.81 1 Yes Yes 0 7 0 1
R:R:L101 R:R:W117 2.28 0 No Yes 5 6 2 1
R:R:S215 R:R:V172 1.62 0 No No 6 5 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.23
Average Nodes In Shell31.00
Average Hubs In Shell13.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6H7J A Amine Adrenergic Beta1 Meleagris gallopavo Isoprenaline - - 2.8 2018-10-17 10.1126/science.aau5595

A 2D representation of the interactions of 5FW in 6H7J
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D121 R:R:V94 7.3 1 No No 7 7 1 2
R:R:V94 R:R:Y333 3.79 1 No Yes 7 7 2 1
R:R:V95 R:R:W330 4.9 1 Yes Yes 7 6 2 2
R:R:V95 R:R:Y333 5.05 1 Yes Yes 7 7 2 1
R:R:F97 R:R:W107 5.01 1 No Yes 4 7 2 2
R:R:F97 R:R:W117 8.02 1 No Yes 4 6 2 1
R:R:G98 R:R:W117 4.22 0 No Yes 6 6 2 1
R:R:W107 R:R:W117 15.93 1 Yes Yes 7 6 2 1
L:L:?1 R:R:W117 4.63 1 Yes Yes 0 6 0 1
R:R:I177 R:R:T118 6.08 1 Yes No 6 6 2 1
L:L:?1 R:R:T118 3.6 1 Yes No 0 6 0 1
R:R:D121 R:R:Y333 10.34 1 No Yes 7 7 1 1
L:L:?1 R:R:D121 24.28 1 Yes No 0 7 0 1
R:R:V122 R:R:Y207 3.79 0 No Yes 6 7 1 2
L:L:?1 R:R:V122 16.96 1 Yes No 0 6 0 1
R:R:V125 R:R:W303 9.81 0 No Yes 6 8 1 2
L:L:?1 R:R:V125 7.27 1 Yes No 0 6 0 1
R:R:S215 R:R:T126 9.59 0 No No 6 6 1 2
R:R:I177 R:R:W182 14.09 1 Yes Yes 6 5 2 2
R:R:I177 R:R:Y207 4.84 1 Yes Yes 6 7 2 2
R:R:F201 R:R:W182 4.01 1 Yes Yes 4 5 1 2
R:R:T203 R:R:W182 3.64 1 Yes Yes 4 5 2 2
R:R:W182 R:R:Y207 6.75 1 Yes Yes 5 7 2 2
R:R:F201 R:R:T203 5.19 1 Yes Yes 4 4 1 2
R:R:F201 R:R:N310 3.62 1 Yes Yes 4 6 1 1
L:L:?1 R:R:F201 10.9 1 Yes Yes 0 4 0 1
R:R:T203 R:R:Y207 6.24 1 Yes Yes 4 7 2 2
R:R:S211 R:R:Y207 10.17 0 No Yes 6 7 1 2
L:L:?1 R:R:S211 8.55 1 Yes No 0 6 0 1
R:R:F307 R:R:S212 5.28 1 Yes No 7 6 1 2
R:R:N310 R:R:S212 4.47 1 Yes No 6 6 1 2
L:L:?1 R:R:S215 7.33 1 Yes No 0 6 0 1
R:R:F216 R:R:F307 21.43 0 Yes Yes 7 7 2 1
R:R:F306 R:R:W303 7.02 1 Yes Yes 7 8 1 2
R:R:F307 R:R:W303 9.02 1 Yes Yes 7 8 1 2
R:R:F306 R:R:F307 13.93 1 Yes Yes 7 7 1 1
R:R:F306 R:R:N310 7.25 1 Yes Yes 7 6 1 1
R:R:F306 R:R:F325 5.36 1 Yes Yes 7 4 1 2
R:R:F306 R:R:N329 14.5 1 Yes No 7 6 1 1
L:L:?1 R:R:F306 10.9 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F307 11.89 1 Yes Yes 0 7 0 1
R:R:F325 R:R:N310 6.04 1 Yes Yes 4 6 2 1
L:L:?1 R:R:N310 4.47 1 Yes Yes 0 6 0 1
R:R:N329 R:R:Y333 15.12 1 No Yes 6 7 1 1
L:L:?1 R:R:N329 14.52 1 Yes No 0 6 0 1
R:R:W330 R:R:Y333 11.58 1 Yes Yes 6 7 2 1
L:L:?1 R:R:Y333 4.77 1 Yes Yes 0 7 0 1
R:R:S211 R:R:V172 1.62 0 No No 6 5 1 2
R:R:S215 R:R:V172 1.62 0 No No 6 5 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.01
Average Nodes In Shell30.00
Average Hubs In Shell17.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DHR A Amine Adrenergic Beta2 Homo sapiens Isoprenaline - Gs/Beta1/Gamma2 3.8 2020-12-16 10.1093/nsr/nwaa284

A 2D representation of the interactions of 5FW in 7DHR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M82 R:R:V86 3.04 1 Yes Yes 7 7 2 2
R:R:M82 R:R:Y316 5.99 1 Yes Yes 7 6 2 1
R:R:D113 R:R:V86 8.76 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 5.05 1 Yes Yes 7 6 2 1
R:R:D113 R:R:Y316 9.2 1 No Yes 7 6 1 1
L:L:?1 R:R:D113 17.66 1 Yes No 0 7 0 1
R:R:V117 R:R:W286 7.36 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 6.06 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 3.2 0 No Yes 5 6 1 2
R:R:F193 R:R:Y174 3.09 1 Yes Yes 4 5 1 2
R:R:Y174 R:R:Y199 8.94 1 Yes Yes 5 6 2 2
R:R:F193 R:R:T195 5.19 1 Yes Yes 4 3 1 2
R:R:F193 R:R:Y199 4.13 1 Yes Yes 4 6 1 2
R:R:F193 R:R:Y308 5.16 1 Yes No 4 5 1 2
L:L:?1 R:R:F193 10.9 1 Yes Yes 0 4 0 1
R:R:T195 R:R:Y199 6.24 1 Yes Yes 3 6 2 2
R:R:S203 R:R:Y199 6.36 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 6.11 1 Yes No 0 5 0 1
L:L:?1 R:R:S207 7.33 1 Yes No 0 5 0 1
R:R:F208 R:R:W286 3.01 1 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 12.86 1 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 10.02 1 Yes Yes 7 8 1 2
R:R:W286 R:R:Y316 2.89 1 Yes Yes 8 6 2 1
R:R:F289 R:R:N312 10.87 0 Yes No 6 5 2 1
R:R:F290 R:R:N293 3.62 1 Yes Yes 7 5 1 1
L:L:?1 R:R:F290 9.91 1 Yes Yes 0 7 0 1
R:R:N293 R:R:V292 2.96 1 Yes No 5 5 1 2
R:R:N293 R:R:Y308 12.79 1 Yes No 5 5 1 2
R:R:N293 R:R:N312 4.09 1 Yes No 5 5 1 1
L:L:?1 R:R:N293 3.35 1 Yes Yes 0 5 0 1
L:L:?1 R:R:N312 4.47 1 Yes No 0 5 0 1
R:R:W313 R:R:Y316 9.65 0 Yes Yes 5 6 2 1
L:L:?1 R:R:Y316 2.86 1 Yes Yes 0 6 0 1
R:R:F193 R:R:T110 2.59 1 Yes No 4 4 1 2
R:R:F290 R:R:S204 1.32 1 Yes No 7 5 1 2
R:R:D192 R:R:F193 1.19 0 No Yes 3 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.63
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JJO A Amine Adrenergic Beta1 Meleagris gallopavo Isoprenaline - Gs/Beta1/Gamma2 2.6 2020-09-02 10.1016/j.molcel.2020.08.001

A 2D representation of the interactions of 5FW in 7JJO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D121 R:R:V94 10.22 2 Yes No 7 7 1 2
R:R:V94 R:R:Y333 5.05 2 No Yes 7 7 2 1
R:R:F97 R:R:W107 5.01 2 Yes Yes 4 7 2 2
R:R:F97 R:R:W117 5.01 2 Yes Yes 4 6 2 1
R:R:G98 R:R:W117 4.22 0 No Yes 6 6 2 1
R:R:W107 R:R:W117 11.25 2 Yes Yes 7 6 2 1
L:L:?401 R:R:W117 4.63 2 Yes Yes 0 6 0 1
R:R:I177 R:R:T118 3.04 2 Yes No 6 6 2 1
L:L:?401 R:R:T118 3.6 2 Yes No 0 6 0 1
R:R:D121 R:R:V125 4.38 2 Yes No 7 6 1 1
R:R:D121 R:R:Y333 12.64 2 Yes Yes 7 7 1 1
L:L:?401 R:R:D121 18.76 2 Yes Yes 0 7 0 1
R:R:S173 R:R:V122 3.23 27 No No 7 6 2 1
L:L:?401 R:R:V122 13.33 2 Yes No 0 6 0 1
R:R:V125 R:R:W303 9.81 2 No Yes 6 8 1 2
L:L:?401 R:R:V125 7.27 2 Yes No 0 6 0 1
R:R:S215 R:R:T126 9.59 0 No Yes 6 6 1 2
R:R:I177 R:R:Y207 4.84 2 Yes Yes 6 7 2 2
R:R:F201 R:R:T203 3.89 2 No Yes 4 4 1 2
R:R:F201 R:R:N310 4.83 2 No No 4 6 1 1
L:L:?401 R:R:F201 21.79 2 Yes No 0 4 0 1
R:R:T203 R:R:Y207 3.75 2 Yes Yes 4 7 2 2
R:R:S211 R:R:Y207 7.63 0 No Yes 6 7 1 2
L:L:?401 R:R:S211 9.77 2 Yes No 0 6 0 1
R:R:F307 R:R:S212 3.96 2 Yes No 7 6 1 2
L:L:?401 R:R:S215 4.88 2 Yes No 0 6 0 1
R:R:F216 R:R:W303 3.01 2 Yes Yes 7 8 2 2
R:R:F216 R:R:F307 18.22 2 Yes Yes 7 7 2 1
R:R:F306 R:R:W303 4.01 2 Yes Yes 7 8 1 2
R:R:F307 R:R:W303 9.02 2 Yes Yes 7 8 1 2
R:R:F306 R:R:F307 9.65 2 Yes Yes 7 7 1 1
R:R:F306 R:R:F325 9.65 2 Yes No 7 4 1 2
R:R:F306 R:R:N329 20.54 2 Yes No 7 6 1 1
L:L:?401 R:R:F306 6.93 2 Yes Yes 0 7 0 1
L:L:?401 R:R:F307 5.94 2 Yes Yes 0 7 0 1
R:R:F325 R:R:N310 7.25 0 No No 4 6 2 1
L:L:?401 R:R:N310 3.35 2 Yes No 0 6 0 1
R:R:N329 R:R:Y333 10.47 2 No Yes 6 7 1 1
L:L:?401 R:R:N329 15.63 2 Yes No 0 6 0 1
R:R:W330 R:R:Y333 3.86 0 Yes Yes 6 7 2 1
L:L:?401 R:R:Y333 5.72 2 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.35
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S0F A Amine Adrenergic Beta1 Meleagris gallopavo Isoprenaline - Gi1/Beta1/Gamma2 2.96 2021-11-17 10.1038/s41594-021-00679-2

A 2D representation of the interactions of 5FW in 7S0F
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D121 R:R:V94 7.3 1 Yes No 7 7 1 2
R:R:V94 R:R:Y333 3.79 1 No Yes 7 7 2 1
R:R:F97 R:R:W107 5.01 1 No Yes 4 7 2 2
R:R:F97 R:R:W117 8.02 1 No Yes 4 6 2 1
R:R:G98 R:R:W117 4.22 0 No Yes 6 6 2 1
R:R:W107 R:R:W117 5.62 1 Yes Yes 7 6 2 1
R:R:T118 R:R:W117 3.64 0 No Yes 6 6 2 1
L:L:?1 R:R:W117 6.48 1 Yes Yes 0 6 0 1
R:R:D121 R:R:V125 4.38 1 Yes Yes 7 6 1 1
R:R:D121 R:R:Y333 12.64 1 Yes Yes 7 7 1 1
L:L:?1 R:R:D121 18.76 1 Yes Yes 0 7 0 1
R:R:S173 R:R:V122 3.23 0 No No 7 6 2 1
R:R:I177 R:R:V122 3.07 0 Yes No 6 6 2 1
L:L:?1 R:R:V122 13.33 1 Yes No 0 6 0 1
R:R:I129 R:R:V125 3.07 1 Yes Yes 8 6 2 1
R:R:V125 R:R:W303 9.81 1 Yes Yes 6 8 1 2
L:L:?1 R:R:V125 8.48 1 Yes Yes 0 6 0 1
R:R:S215 R:R:T126 7.99 1 No No 6 6 1 2
R:R:I129 R:R:W303 10.57 1 Yes Yes 8 8 2 2
R:R:I177 R:R:W182 3.52 0 Yes Yes 6 5 2 2
R:R:I177 R:R:Y207 4.84 0 Yes Yes 6 7 2 2
R:R:F201 R:R:W182 5.01 0 No Yes 4 5 1 2
R:R:F201 R:R:F325 3.22 0 No Yes 4 4 1 2
L:L:?1 R:R:F201 17.83 1 Yes No 0 4 0 1
R:R:S211 R:R:Y207 6.36 0 No Yes 6 7 1 2
L:L:?1 R:R:S211 9.77 1 Yes No 0 6 0 1
R:R:F307 R:R:S212 3.96 1 Yes No 7 6 1 2
R:R:N310 R:R:S212 5.96 1 Yes No 6 6 1 2
R:R:F307 R:R:S215 6.61 1 Yes No 7 6 1 1
L:L:?1 R:R:S215 3.66 1 Yes No 0 6 0 1
R:R:F216 R:R:W303 5.01 1 Yes Yes 7 8 2 2
R:R:F216 R:R:F307 19.29 1 Yes Yes 7 7 2 1
R:R:F306 R:R:W303 5.01 1 Yes Yes 7 8 1 2
R:R:F307 R:R:W303 7.02 1 Yes Yes 7 8 1 2
R:R:F306 R:R:F307 12.86 1 Yes Yes 7 7 1 1
R:R:F306 R:R:N310 4.83 1 Yes Yes 7 6 1 1
R:R:F306 R:R:F325 7.5 1 Yes Yes 7 4 1 2
R:R:F306 R:R:N329 13.29 1 Yes No 7 6 1 1
L:L:?1 R:R:F306 8.92 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F307 7.92 1 Yes Yes 0 7 0 1
R:R:F325 R:R:N310 3.62 1 Yes Yes 4 6 2 1
L:L:?1 R:R:N310 5.58 1 Yes Yes 0 6 0 1
R:R:N329 R:R:Y333 12.79 1 No Yes 6 7 1 1
L:L:?1 R:R:N329 15.63 1 Yes No 0 6 0 1
R:R:W330 R:R:Y333 9.65 0 Yes Yes 6 7 2 1
L:L:?1 R:R:Y333 5.72 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.17
Average Nodes In Shell29.00
Average Hubs In Shell17.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S0G A Amine Adrenergic Beta1 Meleagris gallopavo Isoprenaline - chim(Gi1-CtGs)/Beta1/Gamma2 3.86 2021-11-17 10.1038/s41594-021-00679-2

A 2D representation of the interactions of 5FW in 7S0G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V94 R:R:W117 6.13 4 No Yes 7 6 2 1
R:R:D121 R:R:V94 5.84 4 Yes No 7 7 1 2
R:R:V94 R:R:Y333 3.79 4 No Yes 7 7 2 1
R:R:F97 R:R:W117 9.02 0 No Yes 4 6 2 1
R:R:G98 R:R:W117 4.22 0 No Yes 6 6 2 1
R:R:W107 R:R:W117 14.99 4 Yes Yes 7 6 2 1
R:R:C199 R:R:W107 19.59 4 No Yes 9 7 2 2
R:R:C199 R:R:W117 2.61 4 No Yes 9 6 2 1
L:L:?1 R:R:W117 5.56 4 Yes Yes 0 6 0 1
R:R:F201 R:R:T118 2.59 0 No No 4 6 1 2
R:R:D121 R:R:V125 4.38 4 Yes No 7 6 1 1
R:R:D121 R:R:Y333 11.49 4 Yes Yes 7 7 1 1
L:L:?1 R:R:D121 22.08 4 Yes Yes 0 7 0 1
R:R:S173 R:R:V122 3.23 22 No No 7 6 2 1
R:R:V122 R:R:Y207 3.79 0 No Yes 6 7 1 2
L:L:?1 R:R:V122 10.9 4 Yes No 0 6 0 1
R:R:V125 R:R:W303 9.81 4 No Yes 6 8 1 2
L:L:?1 R:R:V125 6.06 4 Yes No 0 6 0 1
R:R:I129 R:R:W303 8.22 4 Yes Yes 8 8 2 2
R:R:F307 R:R:I129 2.51 4 Yes Yes 7 8 1 2
R:R:F201 R:R:T203 2.59 0 No Yes 4 4 1 2
L:L:?1 R:R:F201 20.8 4 Yes No 0 4 0 1
R:R:T203 R:R:Y207 4.99 9 Yes Yes 4 7 2 2
R:R:S211 R:R:Y207 3.82 0 No Yes 6 7 1 2
L:L:?1 R:R:S211 8.55 4 Yes No 0 6 0 1
R:R:F307 R:R:S212 5.28 4 Yes No 7 6 1 2
R:R:N310 R:R:S212 2.98 0 No No 6 6 1 2
R:R:F307 R:R:S215 2.64 4 Yes No 7 6 1 2
R:R:F216 R:R:W303 4.01 4 Yes Yes 7 8 2 2
R:R:F216 R:R:F307 18.22 4 Yes Yes 7 7 2 1
R:R:F306 R:R:W303 6.01 4 Yes Yes 7 8 1 2
R:R:F307 R:R:W303 5.01 4 Yes Yes 7 8 1 2
R:R:W303 R:R:Y333 2.89 4 Yes Yes 8 7 2 1
R:R:F306 R:R:F307 5.36 4 Yes Yes 7 7 1 1
R:R:F306 R:R:F325 11.79 4 Yes No 7 4 1 2
R:R:F306 R:R:N329 13.29 4 Yes No 7 6 1 1
L:L:?1 R:R:F306 7.92 4 Yes Yes 0 7 0 1
L:L:?1 R:R:F307 4.95 4 Yes Yes 0 7 0 1
L:L:?1 R:R:N310 4.47 4 Yes No 0 6 0 1
R:R:N329 R:R:Y333 16.28 4 No Yes 6 7 1 1
L:L:?1 R:R:N329 10.05 4 Yes No 0 6 0 1
R:R:W330 R:R:Y333 3.86 4 Yes Yes 6 7 2 1
L:L:?1 R:R:Y333 8.58 4 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.99
Average Nodes In Shell28.00
Average Hubs In Shell13.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XJH A Amine Adrenergic Beta3 Canis lupus familiaris Isoproterenol - Gs/Beta1/Gamma2 3.3 2022-05-04 10.1016/j.molcel.2021.06.024

A 2D representation of the interactions of 5FW in 7XJH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V90 R:R:W113 4.9 4 No Yes 7 5 2 1
R:R:D117 R:R:V90 11.69 4 Yes No 7 7 1 2
R:R:V90 R:R:Y336 5.05 4 No Yes 7 7 2 2
R:R:P93 R:R:W113 8.11 0 No Yes 5 5 2 1
R:R:G94 R:R:W113 5.63 0 No Yes 7 5 2 1
R:R:W103 R:R:W113 10.31 4 Yes Yes 7 5 2 1
R:R:C196 R:R:W103 7.84 4 No Yes 9 7 2 2
R:R:C196 R:R:W113 3.92 4 No Yes 9 5 2 1
L:L:?1 R:R:W113 6.48 4 Yes Yes 0 5 0 1
L:L:?1 R:R:T114 3.6 4 Yes No 0 5 0 1
R:R:D117 R:R:V121 4.38 4 Yes No 7 7 1 1
R:R:D117 R:R:Y336 10.34 4 Yes Yes 7 7 1 2
L:L:?1 R:R:D117 20.97 4 Yes Yes 0 7 0 1
R:R:S169 R:R:V118 6.46 0 No No 7 7 2 1
L:L:?1 R:R:V118 9.69 4 Yes No 0 7 0 1
R:R:V121 R:R:W305 8.58 4 No Yes 7 8 1 2
L:L:?1 R:R:V121 9.69 4 Yes No 0 7 0 1
R:R:S212 R:R:T122 9.59 0 No No 6 7 1 2
R:R:F198 R:R:S200 7.93 0 No No 5 4 1 2
R:R:F198 R:R:N312 9.67 0 No No 5 7 1 2
L:L:?1 R:R:F198 12.88 4 Yes No 0 5 0 1
R:R:S200 R:R:Y204 5.09 0 No Yes 4 8 2 2
R:R:S208 R:R:Y204 7.63 0 No Yes 6 8 1 2
L:L:?1 R:R:S208 9.77 4 Yes No 0 6 0 1
R:R:F309 R:R:S209 5.28 4 Yes No 7 7 1 2
R:R:N312 R:R:S209 4.47 0 No No 7 7 2 2
L:L:?1 R:R:S212 7.33 4 Yes No 0 6 0 1
R:R:F213 R:R:F309 20.36 4 Yes Yes 8 7 2 1
R:R:F308 R:R:W305 7.02 4 Yes Yes 7 8 1 2
R:R:F309 R:R:W305 8.02 4 Yes Yes 7 8 1 2
R:R:F308 R:R:F309 11.79 4 Yes Yes 7 7 1 1
R:R:F308 R:R:N312 4.83 4 Yes No 7 7 1 2
R:R:F308 R:R:L331 3.65 4 Yes No 7 6 1 2
R:R:F308 R:R:N332 16.92 4 Yes No 7 6 1 1
L:L:?1 R:R:F308 6.93 4 Yes Yes 0 7 0 1
L:L:?1 R:R:F309 5.94 4 Yes Yes 0 7 0 1
R:R:N332 R:R:Y336 5.81 4 No Yes 6 7 1 2
L:L:?1 R:R:N332 11.17 4 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.50
Average Nodes In Shell27.00
Average Hubs In Shell10.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.57
Average Number Of Links With An Hub5.14
Average Interaction Strength9.41
Average Nodes In Shell28.29
Average Hubs In Shell14.29
Average Links In Shell42.86
Average Links Mediated by Hubs In Shell40.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)