| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8X2K | A | Orphan | Orphan | GPR3 | Homo Sapiens | Oleic monoethanolamide | - | chim(NtGi1-Gs)/Beta1/Gamma2 | 3.03 | 2024-04-03 | doi.org/10.1038/s41422-023-00919-8 |
|
A 2D representation of the interactions of 5YM in 8X2K
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:V113 | 4.84 | 5 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:T121 | 9.58 | 5 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I124 | 4.64 | 5 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:L198 | 5.4 | 5 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:A201 | 3.07 | 5 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:W260 | 4.44 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:G92 | R:R:L116 | 3.42 | 0 | No | No | 4 | 5 | 2 | 1 | | R:R:L116 | R:R:L93 | 11.07 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:P189 | R:R:V113 | 5.3 | 5 | Yes | No | 3 | 4 | 2 | 1 | | R:R:F120 | R:R:W260 | 9.02 | 0 | No | Yes | 4 | 8 | 2 | 1 | | R:R:L198 | R:R:T121 | 2.95 | 5 | Yes | No | 6 | 6 | 1 | 1 | | R:R:I124 | R:R:S123 | 3.1 | 5 | No | No | 8 | 9 | 1 | 2 | | R:R:I124 | R:R:W260 | 14.09 | 5 | No | Yes | 8 | 8 | 1 | 1 | | R:R:L167 | R:R:L198 | 5.54 | 0 | No | Yes | 6 | 6 | 2 | 1 | | R:R:H194 | R:R:L198 | 5.14 | 5 | Yes | Yes | 7 | 6 | 2 | 1 | | R:R:F202 | R:R:W260 | 10.02 | 5 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:A286 | R:R:W260 | 7.78 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:N289 | R:R:W260 | 9.04 | 0 | No | Yes | 9 | 8 | 2 | 1 | | L:L:?1 | R:R:L116 | 1.8 | 5 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:G125 | 1.11 | 5 | Yes | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.36 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 20.00 | | Average Links Mediated by Hubs In Shell | 17.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9M88 | A | Orphan | Orphan | GPR3 ; GPR3 | Homo Sapiens | Oleic monoethanolamide | AF64394 | - | 3.1 | 2025-09-24 | doi.org/10.1038/s41467-025-63422-1 |
|
A 2D representation of the interactions of 5YM in 9M88
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:L116 | 3.16 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:F120 | 8.35 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:T121 | 7.86 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I124 | 8.7 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:L198 | 5.27 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F202 | 3.71 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F263 | 2.78 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:L283 | 6.33 | 2 | Yes | No | 0 | 4 | 0 | 1 | | R:R:A89 | R:R:F120 | 2.77 | 0 | No | No | 8 | 5 | 2 | 1 | | R:R:L116 | R:R:L93 | 2.77 | 0 | No | Yes | 5 | 6 | 1 | 2 | | R:R:F120 | R:R:W260 | 7.02 | 0 | No | Yes | 5 | 8 | 1 | 2 | | R:R:A164 | R:R:T121 | 3.36 | 0 | No | No | 8 | 6 | 2 | 1 | | R:R:F202 | R:R:I124 | 3.77 | 2 | Yes | No | 7 | 7 | 1 | 1 | | R:R:I124 | R:R:W260 | 9.4 | 2 | No | Yes | 7 | 8 | 1 | 2 | | R:R:L167 | R:R:L198 | 4.15 | 0 | No | No | 4 | 6 | 2 | 1 | | R:R:H194 | R:R:L198 | 9 | 0 | Yes | No | 6 | 6 | 2 | 1 | | R:R:F202 | R:R:F203 | 5.36 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | | R:R:F202 | R:R:F256 | 5.36 | 2 | Yes | No | 7 | 8 | 1 | 2 | | R:R:F202 | R:R:W260 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F202 | R:R:T264 | 14.27 | 2 | Yes | No | 7 | 6 | 1 | 2 | | R:R:F203 | R:R:T264 | 3.89 | 2 | Yes | No | 5 | 6 | 2 | 2 | | R:R:F256 | R:R:W260 | 4.01 | 2 | No | Yes | 8 | 8 | 2 | 2 | | R:R:F263 | R:R:T282 | 7.78 | 2 | No | No | 5 | 4 | 1 | 2 | | R:R:F263 | R:R:L283 | 8.53 | 2 | No | No | 5 | 4 | 1 | 1 | | R:R:G92 | R:R:L116 | 1.71 | 0 | No | No | 5 | 5 | 2 | 1 | | L:L:?1 | R:R:A201 | 1.2 | 2 | Yes | No | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.26 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 26.00 | | Average Links Mediated by Hubs In Shell | 20.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of 5YM in 9M88
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:F120 | 8.35 | 2 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:T121 | 7.86 | 2 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:I124 | 8.7 | 2 | Yes | No | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:L198 | 3.16 | 2 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:F202 | 3.71 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:F263 | 2.78 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:L283 | 6.33 | 2 | Yes | No | 0 | 4 | 0 | 1 | | S:S:A89 | S:S:F120 | 2.77 | 0 | No | No | 8 | 5 | 2 | 1 | | S:S:F120 | S:S:W260 | 8.02 | 0 | No | Yes | 5 | 8 | 1 | 2 | | S:S:A164 | S:S:T121 | 3.36 | 0 | No | No | 8 | 6 | 2 | 1 | | S:S:L167 | S:S:T121 | 2.95 | 0 | No | No | 4 | 6 | 2 | 1 | | S:S:I124 | S:S:W260 | 11.74 | 0 | No | Yes | 7 | 8 | 1 | 2 | | S:S:L167 | S:S:L198 | 2.77 | 0 | No | No | 4 | 6 | 2 | 1 | | S:S:H194 | S:S:L198 | 6.43 | 0 | No | No | 6 | 6 | 2 | 1 | | S:S:F202 | S:S:F203 | 5.36 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | | S:S:F202 | S:S:F256 | 5.36 | 2 | Yes | No | 7 | 8 | 1 | 2 | | S:S:F202 | S:S:W260 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | | S:S:F202 | S:S:T264 | 14.27 | 2 | Yes | No | 7 | 6 | 1 | 2 | | S:S:F203 | S:S:T264 | 5.19 | 2 | Yes | No | 5 | 6 | 2 | 2 | | S:S:F263 | S:S:T282 | 3.89 | 2 | Yes | No | 5 | 4 | 1 | 2 | | S:S:F263 | S:S:L283 | 8.53 | 2 | Yes | No | 5 | 4 | 1 | 1 | | S:S:F263 | S:S:V187 | 2.62 | 2 | Yes | No | 5 | 4 | 1 | 2 | | M:M:?1 | S:S:A201 | 1.2 | 2 | Yes | No | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 5.26 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 18.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9M8P | A | Orphan | Orphan | GPR3 ; GPR3 | Homo Sapiens | Oleic monoethanolamide | AF64394 | - | 3.42 | 2025-09-24 | doi.org/10.1038/s41467-025-63422-1 |
|
A 2D representation of the interactions of 5YM in 9M8P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:H96 | 7.84 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:V113 | 4.54 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:L116 | 7.38 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:F120 | 5.57 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:T121 | 5.61 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I124 | 7.61 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V187 | 4.54 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:L198 | 3.16 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F202 | 5.57 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:W260 | 6.07 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F263 | 5.57 | 2 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:L283 | 5.27 | 2 | Yes | No | 0 | 4 | 0 | 1 | | R:R:A89 | R:R:F120 | 4.16 | 0 | No | No | 8 | 5 | 2 | 1 | | R:R:G92 | R:R:L116 | 3.42 | 0 | No | No | 5 | 5 | 2 | 1 | | R:R:L116 | R:R:L93 | 4.15 | 0 | No | Yes | 5 | 6 | 1 | 2 | | R:R:H96 | R:R:V100 | 6.92 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:P189 | R:R:V113 | 10.6 | 0 | No | No | 2 | 5 | 2 | 1 | | R:R:F120 | R:R:W260 | 7.02 | 2 | No | Yes | 5 | 8 | 1 | 1 | | R:R:A164 | R:R:T121 | 3.36 | 0 | No | No | 8 | 6 | 2 | 1 | | R:R:F202 | R:R:I124 | 3.77 | 2 | Yes | No | 7 | 7 | 1 | 1 | | R:R:I124 | R:R:W260 | 10.57 | 2 | No | Yes | 7 | 8 | 1 | 1 | | R:R:L167 | R:R:L198 | 4.15 | 0 | No | No | 4 | 6 | 2 | 1 | | R:R:L190 | R:R:V187 | 8.94 | 7 | Yes | No | 3 | 4 | 2 | 1 | | R:R:H194 | R:R:L190 | 3.86 | 7 | Yes | Yes | 6 | 3 | 2 | 2 | | R:R:H194 | R:R:L198 | 11.57 | 7 | Yes | No | 6 | 6 | 2 | 1 | | R:R:F202 | R:R:F203 | 5.36 | 2 | Yes | No | 7 | 5 | 1 | 2 | | R:R:F202 | R:R:F256 | 4.29 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F202 | R:R:W260 | 5.01 | 2 | Yes | Yes | 7 | 8 | 1 | 1 | | R:R:F202 | R:R:T264 | 12.97 | 2 | Yes | No | 7 | 6 | 1 | 2 | | R:R:F203 | R:R:T264 | 3.89 | 2 | No | No | 5 | 6 | 2 | 2 | | R:R:F256 | R:R:W260 | 4.01 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:F263 | R:R:W260 | 4.01 | 2 | No | Yes | 5 | 8 | 1 | 1 | | R:R:A286 | R:R:W260 | 7.78 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:N289 | R:R:W260 | 6.78 | 0 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F263 | R:R:T282 | 6.49 | 2 | No | No | 5 | 4 | 1 | 2 | | R:R:H96 | R:R:L112 | 2.57 | 0 | No | No | 5 | 5 | 1 | 2 | | L:L:?1 | R:R:A201 | 2.4 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:L47 | 2.11 | 2 | Yes | No | 0 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 14.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 5.23 | | Average Nodes In Shell | 31.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 38.00 | | Average Links Mediated by Hubs In Shell | 29.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of 5YM in 9M8P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:H96 | 8.81 | 3 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:V113 | 3.4 | 3 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:L116 | 7.38 | 3 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:F120 | 6.49 | 3 | Yes | No | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:T121 | 4.49 | 3 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:I124 | 9.79 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:L198 | 3.16 | 3 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:F202 | 5.57 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:W260 | 5.21 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | | M:M:?1 | S:S:F263 | 4.64 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:L283 | 6.33 | 3 | Yes | No | 0 | 4 | 0 | 1 | | S:S:A89 | S:S:F120 | 4.16 | 0 | No | No | 8 | 5 | 2 | 1 | | S:S:L116 | S:S:L93 | 4.15 | 0 | No | Yes | 5 | 6 | 1 | 2 | | S:S:H96 | S:S:V100 | 6.92 | 0 | No | No | 5 | 4 | 1 | 2 | | S:S:P189 | S:S:V113 | 7.07 | 0 | No | No | 2 | 5 | 2 | 1 | | S:S:F120 | S:S:W260 | 8.02 | 3 | No | Yes | 5 | 8 | 1 | 1 | | S:S:A164 | S:S:T121 | 3.36 | 0 | No | No | 8 | 6 | 2 | 1 | | S:S:L167 | S:S:T121 | 4.42 | 0 | No | No | 4 | 6 | 2 | 1 | | S:S:F202 | S:S:I124 | 3.77 | 3 | Yes | Yes | 7 | 7 | 1 | 1 | | S:S:F256 | S:S:I124 | 3.77 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:I124 | S:S:W260 | 7.05 | 3 | Yes | Yes | 7 | 8 | 1 | 1 | | S:S:L167 | S:S:L198 | 4.15 | 0 | No | No | 4 | 6 | 2 | 1 | | S:S:H194 | S:S:L198 | 9 | 11 | No | No | 6 | 6 | 2 | 1 | | S:S:F202 | S:S:F203 | 5.36 | 3 | Yes | Yes | 7 | 5 | 1 | 2 | | S:S:F202 | S:S:F256 | 5.36 | 3 | Yes | Yes | 7 | 8 | 1 | 2 | | S:S:F202 | S:S:T264 | 15.56 | 3 | Yes | No | 7 | 6 | 1 | 2 | | S:S:F203 | S:S:T264 | 3.89 | 3 | Yes | No | 5 | 6 | 2 | 2 | | S:S:F256 | S:S:W260 | 5.01 | 3 | Yes | Yes | 8 | 8 | 2 | 1 | | S:S:F256 | S:S:N289 | 6.04 | 3 | Yes | Yes | 8 | 9 | 2 | 2 | | S:S:F263 | S:S:W260 | 4.01 | 3 | Yes | Yes | 5 | 8 | 1 | 1 | | S:S:A286 | S:S:W260 | 7.78 | 0 | No | Yes | 6 | 8 | 2 | 1 | | S:S:N289 | S:S:W260 | 6.78 | 3 | Yes | Yes | 9 | 8 | 2 | 1 | | S:S:C267 | S:S:F263 | 8.38 | 0 | No | Yes | 5 | 5 | 2 | 1 | | S:S:F263 | S:S:T282 | 3.89 | 3 | Yes | No | 5 | 4 | 1 | 2 | | S:S:F263 | S:S:L283 | 3.65 | 3 | Yes | No | 5 | 4 | 1 | 1 | | M:M:?1 | S:S:A201 | 2.4 | 3 | Yes | No | 0 | 4 | 0 | 1 | | S:S:G125 | S:S:I124 | 1.76 | 0 | No | Yes | 4 | 7 | 2 | 1 | | S:S:G92 | S:S:L116 | 1.71 | 0 | No | No | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 12.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 5.64 | | Average Nodes In Shell | 29.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 38.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
