Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 4PXZ | A | Nucleotide | P2Y | P2Y12 | Homo sapiens | 2MeSADP | - | - | 2.5 | 2014-04-30 | 10.1038/nature13288 |
![](/psngpcr/ligands/6AD/6AD_4PXZ_L_L_1.png)
A 2D representation of the interactions of 6AD in 4PXZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R93 | R:R:S83 | 3.95 | 1 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:C97 | R:R:R93 | 6.96 | 1 | No | Yes | 9 | 7 | 2 | 1 | R:R:K173 | R:R:R93 | 7.43 | 0 | No | Yes | 4 | 7 | 2 | 1 | R:R:C175 | R:R:R93 | 4.18 | 1 | No | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:R93 | 3.77 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:C175 | R:R:C97 | 7.28 | 1 | No | No | 9 | 9 | 1 | 2 | L:L:?1 | R:R:S101 | 3.73 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:M160 | R:R:V102 | 7.61 | 0 | No | No | 4 | 6 | 2 | 1 | L:L:?1 | R:R:V102 | 7.4 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F252 | R:R:Y105 | 6.19 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:R256 | R:R:Y105 | 6.17 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:K280 | R:R:Y105 | 3.58 | 1 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:L284 | R:R:Y105 | 4.69 | 1 | No | Yes | 6 | 5 | 2 | 1 | L:L:?1 | R:R:Y105 | 35.67 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:C194 | R:R:Y109 | 17.47 | 0 | No | Yes | 5 | 7 | 1 | 2 | R:R:N159 | R:R:W186 | 9.04 | 1 | No | Yes | 5 | 5 | 1 | 2 | R:R:N159 | R:R:V190 | 7.39 | 1 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:N159 | 11.09 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:K179 | R:R:T163 | 10.51 | 1 | Yes | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:C175 | 11.83 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:K179 | R:R:L184 | 4.23 | 1 | Yes | No | 5 | 3 | 1 | 2 | R:R:H187 | R:R:K179 | 3.93 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?1 | R:R:K179 | 7.01 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:V190 | R:R:W186 | 7.36 | 1 | No | Yes | 5 | 5 | 1 | 2 | R:R:H187 | R:R:N191 | 6.38 | 1 | Yes | Yes | 4 | 5 | 1 | 1 | R:R:H187 | R:R:Q263 | 11.13 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | L:L:?1 | R:R:H187 | 13.57 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:V190 | 8.33 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:N191 | R:R:R256 | 13.26 | 1 | Yes | Yes | 5 | 6 | 1 | 1 | R:R:N191 | R:R:T260 | 10.24 | 1 | Yes | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:N191 | 11.94 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:C194 | 4.93 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F252 | R:R:R256 | 8.55 | 1 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:F252 | R:R:L284 | 6.09 | 1 | Yes | No | 7 | 6 | 2 | 2 | R:R:R256 | R:R:Y259 | 6.17 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | R:R:R256 | R:R:T260 | 6.47 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:Q263 | R:R:R256 | 4.67 | 1 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:R256 | 6.79 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S262 | R:R:Y259 | 3.82 | 0 | No | Yes | 2 | 4 | 2 | 1 | R:R:Q263 | R:R:Y259 | 18.04 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:F277 | R:R:Y259 | 6.19 | 0 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:K280 | R:R:Y259 | 17.91 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:Y259 | 4.37 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Q263 | 7.44 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:E281 | R:R:F277 | 7 | 0 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:E281 | R:R:K280 | 4.05 | 0 | Yes | Yes | 5 | 5 | 2 | 1 | L:L:?1 | R:R:K280 | 8.76 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 9.78 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 16.00 | Average Links In Shell | 47.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/6AD/6AD_4PXZ_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/6AD/6AD_4PXZ_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XXH | A | Nucleotide | P2Y | P2Y1 | Homo sapiens | 2MeSADP | - | chim(NtGi1-G11)/Beta1/Gamma2 | 2.9 | 2023-06-07 | 10.1093/procel/pwac025 |
![](/psngpcr/ligands/6AD/6AD_7XXH_L_L_1.png)
A 2D representation of the interactions of 6AD in 7XXH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:F51 | R:R:Y111 | 4.13 | 0 | No | Yes | 3 | 5 | 2 | 1 | R:R:F51 | R:R:T115 | 3.89 | 0 | No | No | 3 | 4 | 2 | 2 | R:R:F51 | R:R:Y303 | 13.41 | 0 | No | No | 3 | 4 | 2 | 1 | R:R:L54 | R:R:Y58 | 5.86 | 0 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:L54 | R:R:Y111 | 3.52 | 0 | Yes | Yes | 6 | 5 | 2 | 1 | R:R:L54 | R:R:Q307 | 3.99 | 0 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:R310 | R:R:Y58 | 3.09 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:L107 | R:R:R128 | 9.72 | 0 | No | Yes | 7 | 5 | 2 | 1 | R:R:Y110 | R:R:Y111 | 14.89 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:T115 | R:R:Y110 | 4.99 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:W117 | R:R:Y110 | 11.58 | 2 | Yes | Yes | 8 | 5 | 2 | 1 | R:R:R128 | R:R:Y110 | 3.09 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:C202 | R:R:Y110 | 6.72 | 2 | Yes | Yes | 9 | 5 | 2 | 1 | L:L:?1 | R:R:Y110 | 8.74 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:R128 | R:R:Y111 | 3.09 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | R:R:R310 | R:R:Y111 | 6.17 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?1 | R:R:Y111 | 8.01 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:T115 | R:R:T201 | 4.71 | 0 | No | Yes | 4 | 3 | 2 | 1 | R:R:C202 | R:R:W117 | 13.06 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:C202 | R:R:R128 | 9.75 | 2 | Yes | Yes | 9 | 5 | 2 | 1 | R:R:D204 | R:R:R128 | 13.1 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:R128 | 4.53 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:D204 | R:R:H132 | 3.78 | 2 | Yes | No | 6 | 5 | 1 | 2 | R:R:K196 | R:R:R195 | 17.33 | 0 | No | Yes | 2 | 1 | 2 | 1 | R:R:N197 | R:R:R195 | 7.23 | 0 | No | Yes | 4 | 1 | 2 | 1 | R:R:R195 | R:R:T201 | 9.06 | 2 | Yes | Yes | 1 | 3 | 1 | 1 | R:R:R195 | R:R:Y203 | 9.26 | 2 | Yes | Yes | 1 | 4 | 1 | 1 | L:L:?1 | R:R:R195 | 11.32 | 2 | Yes | Yes | 0 | 1 | 0 | 1 | R:R:T201 | R:R:Y203 | 19.97 | 2 | Yes | Yes | 3 | 4 | 1 | 1 | L:L:?1 | R:R:T201 | 3.66 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | L:L:?1 | R:R:Y203 | 10.19 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:D204 | R:R:T205 | 10.12 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:D204 | R:R:R310 | 3.57 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | L:L:?1 | R:R:D204 | 14.33 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:T205 | R:R:T206 | 4.71 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:T205 | R:R:Y214 | 11.24 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:T205 | 10.07 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L211 | R:R:T206 | 4.42 | 0 | Yes | No | 4 | 5 | 2 | 2 | R:R:T206 | R:R:Y214 | 11.24 | 2 | No | Yes | 5 | 4 | 2 | 2 | R:R:L211 | R:R:R287 | 3.64 | 0 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:N283 | R:R:R287 | 9.64 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:N283 | R:R:Y306 | 8.14 | 0 | No | Yes | 4 | 4 | 2 | 2 | R:R:Q291 | R:R:R287 | 10.51 | 0 | No | Yes | 2 | 5 | 2 | 1 | L:L:?1 | R:R:R287 | 10.56 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:Q307 | R:R:Y303 | 19.16 | 2 | Yes | No | 5 | 4 | 2 | 1 | L:L:?1 | R:R:Y303 | 10.92 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:Q307 | R:R:Y306 | 5.64 | 2 | Yes | Yes | 5 | 4 | 2 | 2 | R:R:R310 | R:R:Y306 | 14.4 | 2 | Yes | Yes | 5 | 4 | 1 | 2 | R:R:Q307 | R:R:R310 | 8.18 | 2 | Yes | Yes | 5 | 5 | 2 | 1 | L:L:?1 | R:R:R310 | 3.02 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:G193 | R:R:Y203 | 2.9 | 0 | No | Yes | 2 | 4 | 2 | 1 | L:L:?1 | R:R:T45 | 2.75 | 2 | Yes | No | 0 | 3 | 0 | 1 | R:R:S207 | R:R:Y203 | 1.27 | 0 | No | Yes | 5 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 10.00 | Average Interaction Strength | 8.17 | Average Nodes In Shell | 32.00 | Average Hubs In Shell | 19.00 | Average Links In Shell | 53.00 | Average Links Mediated by Hubs In Shell | 51.00 |
| ![](/psngpcr/ligands/6AD/6AD_7XXH_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/6AD/6AD_7XXH_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XXI | A | Nucleotide | P2Y | P2Y12 | Homo sapiens | 2MeSADP | - | Gi2/Beta1/Gamma2 | 3 | 2023-06-07 | 10.1093/procel/pwac025 |
![](/psngpcr/ligands/6AD/6AD_7XXI_L_L_1.png)
A 2D representation of the interactions of 6AD in 7XXI colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R93 | R:R:S83 | 7.91 | 2 | Yes | Yes | 7 | 6 | 1 | 2 | R:R:C97 | R:R:R93 | 4.18 | 2 | No | Yes | 9 | 7 | 2 | 1 | R:R:C175 | R:R:R93 | 8.36 | 2 | No | Yes | 9 | 7 | 1 | 1 | L:L:?1 | R:R:R93 | 3.02 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:C175 | R:R:C97 | 7.28 | 2 | No | No | 9 | 9 | 1 | 2 | R:R:S101 | R:R:V102 | 3.23 | 2 | No | Yes | 6 | 6 | 1 | 1 | R:R:S101 | R:R:Y105 | 5.09 | 2 | No | No | 6 | 5 | 1 | 1 | L:L:?1 | R:R:S101 | 7.46 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:S156 | R:R:V102 | 3.23 | 2 | No | Yes | 6 | 6 | 2 | 1 | R:R:N159 | R:R:V102 | 2.96 | 2 | No | Yes | 5 | 6 | 1 | 1 | R:R:M160 | R:R:V102 | 7.61 | 2 | No | Yes | 4 | 6 | 2 | 1 | L:L:?1 | R:R:V102 | 8.33 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L284 | R:R:Y105 | 3.52 | 2 | Yes | No | 6 | 5 | 2 | 1 | L:L:?1 | R:R:Y105 | 26.94 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:M108 | R:R:Y109 | 5.99 | 2 | Yes | No | 7 | 7 | 2 | 1 | R:R:C194 | R:R:Y109 | 10.75 | 0 | No | No | 5 | 7 | 2 | 1 | L:L:?1 | R:R:Y109 | 10.92 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:M160 | R:R:S156 | 3.07 | 2 | No | No | 4 | 6 | 2 | 2 | R:R:N159 | R:R:V190 | 2.96 | 2 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:N159 | 10.23 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:C175 | 3.94 | 2 | Yes | No | 0 | 9 | 0 | 1 | R:R:Q263 | R:R:S176 | 11.55 | 2 | Yes | No | 4 | 4 | 1 | 2 | R:R:H187 | R:R:K179 | 9.17 | 2 | Yes | Yes | 4 | 5 | 1 | 2 | R:R:V190 | R:R:W186 | 4.9 | 2 | No | No | 5 | 5 | 1 | 2 | R:R:H187 | R:R:N191 | 16.58 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | L:L:?1 | R:R:H187 | 11.98 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:V190 | 3.7 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:N191 | R:R:R256 | 6.03 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | R:R:N191 | R:R:T260 | 14.62 | 2 | Yes | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:N191 | 6.82 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:Q195 | R:R:R256 | 3.5 | 0 | Yes | Yes | 3 | 6 | 2 | 1 | R:R:F252 | R:R:R256 | 5.34 | 0 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:F252 | R:R:L284 | 3.65 | 0 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:R256 | R:R:Y259 | 5.14 | 2 | Yes | Yes | 6 | 4 | 1 | 1 | R:R:R256 | R:R:T260 | 5.17 | 2 | Yes | No | 6 | 5 | 1 | 2 | R:R:Q263 | R:R:R256 | 3.5 | 2 | Yes | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:R256 | 8.3 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:Q263 | R:R:Y259 | 12.4 | 2 | Yes | Yes | 4 | 4 | 1 | 1 | R:R:F277 | R:R:Y259 | 6.19 | 0 | No | Yes | 4 | 4 | 2 | 1 | R:R:K280 | R:R:Y259 | 28.66 | 2 | No | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:Y259 | 5.82 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:Q263 | 14.88 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?1 | R:R:K280 | 6.13 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:H187 | R:R:T264 | 2.74 | 2 | Yes | No | 4 | 3 | 1 | 2 | R:R:R93 | R:R:T89 | 2.59 | 2 | Yes | No | 7 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 9.18 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 45.00 | Average Links Mediated by Hubs In Shell | 39.00 |
| ![](/psngpcr/ligands/6AD/6AD_7XXI_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/6AD/6AD_7XXI_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|