Code7WT
NameZ-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(3R)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid
Synonyms7-[3,5-Dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]hept-5-enoic acid
Identifier(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-3,5-bis(oxidanyl)-2-[(3~{R})-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid
FormulaC23 H34 O5
Molecular Weight390.513
SMILESc1ccc(cc1)CC[C@@H](CC[C@H]2[C@@H](C[C@@H]([C@@H]2C/C=C\CCCC(=O)O)O)O)O
PubChem6441636
Formal Charge0
Total Atoms62
Total Chiral Atoms5
Total Bonds63
Total Aromatic Bonds6
Networks3
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This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IQ6 A Lipid Prostanoid FP-alpha Homo Sapiens Latanoprost - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.4 2024-01-31 10.1038/s41467-023-43922-8

A 2D representation of the interactions of 7WT in 8IQ6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S33 R:R:V30 3.23 0 No Yes 7 6 1 2
R:R:V30 R:R:Y92 11.36 0 Yes Yes 6 8 2 1
L:L:?1 R:R:S33 6.11 1 Yes No 0 7 0 1
R:R:F36 R:R:T294 5.19 1 Yes No 8 9 1 1
R:R:F36 R:R:W295 8.02 1 Yes No 8 5 1 2
R:R:F36 R:R:I298 5.02 1 Yes No 8 8 1 2
L:L:?1 R:R:F36 3.3 1 Yes Yes 0 8 0 1
R:R:G85 R:R:M37 3.49 0 No No 7 7 1 2
R:R:G40 R:R:H81 3.18 0 No No 9 8 2 1
R:R:D77 R:R:P122 3.22 1 Yes No 9 9 2 2
R:R:D77 R:R:Q297 3.92 1 Yes Yes 9 8 2 1
R:R:G80 R:R:S118 3.71 0 No No 8 7 2 1
R:R:H81 R:R:Q297 3.71 1 No Yes 8 8 1 1
L:L:?1 R:R:H81 13.08 1 Yes No 0 8 0 1
R:R:F111 R:R:N84 4.83 1 Yes Yes 6 6 2 1
R:R:C114 R:R:N84 4.72 0 No Yes 4 6 2 1
R:R:M115 R:R:N84 9.82 1 Yes Yes 8 6 1 1
R:R:N84 R:R:S118 4.47 1 Yes No 6 7 1 1
L:L:?1 R:R:N84 5.59 1 Yes Yes 0 6 0 1
L:L:?1 R:R:G85 4.64 1 Yes No 0 7 0 1
L:L:?1 R:R:A88 3.21 1 Yes No 0 8 0 1
R:R:K96 R:R:Y92 3.58 1 No Yes 5 8 2 1
R:R:T184 R:R:Y92 7.49 1 Yes Yes 9 8 1 1
L:L:?1 R:R:Y92 4.77 1 Yes Yes 0 8 0 1
R:R:K96 R:R:T184 3 1 No Yes 5 9 2 1
R:R:F111 R:R:M115 4.98 1 Yes Yes 6 8 2 1
R:R:L290 R:R:M115 4.24 1 No Yes 7 8 1 1
L:L:?1 R:R:M115 11.51 1 Yes Yes 0 8 0 1
L:L:?1 R:R:S118 3.06 1 Yes No 0 7 0 1
R:R:P122 R:R:Q297 11.05 1 No Yes 9 8 2 1
R:R:L123 R:R:W262 14.81 0 No Yes 7 9 2 1
R:R:Q180 R:R:W185 20.81 1 No Yes 8 8 2 1
R:R:F187 R:R:Q180 5.86 1 Yes No 8 8 2 2
R:R:S182 R:R:W185 4.94 0 No Yes 8 8 2 1
R:R:T184 R:R:W185 3.64 1 Yes Yes 9 8 1 1
L:L:?1 R:R:T184 8 1 Yes Yes 0 9 0 1
R:R:F187 R:R:W185 7.02 1 Yes Yes 8 8 2 1
R:R:L290 R:R:W185 11.39 1 No Yes 7 8 1 1
L:L:?1 R:R:W185 3.86 1 Yes Yes 0 8 0 1
R:R:F187 R:R:M269 3.73 1 Yes No 8 7 2 2
R:R:F265 R:R:W262 6.01 1 Yes Yes 8 9 1 1
R:R:A293 R:R:W262 6.48 0 No Yes 8 9 2 1
R:R:N296 R:R:W262 15.82 0 No Yes 9 9 2 1
R:R:Q297 R:R:W262 5.48 1 Yes Yes 8 9 1 1
L:L:?1 R:R:W262 3.86 1 Yes Yes 0 9 0 1
R:R:F265 R:R:M269 7.46 1 Yes No 8 7 1 2
R:R:A289 R:R:F265 4.16 0 No Yes 7 8 2 1
L:L:?1 R:R:F265 5.78 1 Yes Yes 0 8 0 1
L:L:?1 R:R:L290 11.27 1 Yes No 0 7 0 1
L:L:?1 R:R:T294 8 1 Yes No 0 9 0 1
R:R:I298 R:R:W295 3.52 1 No No 8 5 2 2
L:L:?1 R:R:Q297 4.51 1 Yes Yes 0 8 0 1
R:R:G119 R:R:W262 2.81 0 No Yes 7 9 2 1
R:R:T286 R:R:W185 2.43 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub9.00
Average Interaction Strength6.28
Average Nodes In Shell38.00
Average Hubs In Shell14.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IUL A Lipid Prostanoid FP-alpha Homo Sapiens Latanoprost - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.78 2023-07-12 10.1038/s41467-023-38411-x

A 2D representation of the interactions of 7WT in 8IUL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S29 R:R:Y92 3.82 0 No Yes 7 8 2 1
R:R:V30 R:R:Y92 8.83 0 No Yes 6 8 2 1
R:R:A88 R:R:S33 3.42 0 No No 8 7 2 1
L:L:?1 R:R:S33 8.29 3 Yes No 0 7 0 1
R:R:F36 R:R:R291 4.28 0 No No 8 8 2 2
R:R:F36 R:R:T294 5.19 0 No No 8 9 2 1
R:R:G80 R:R:S118 3.71 0 No No 8 7 2 1
R:R:H81 R:R:Q297 4.95 0 No Yes 8 8 1 2
L:L:?1 R:R:H81 18.93 3 Yes No 0 8 0 1
R:R:F111 R:R:N84 9.67 0 No No 6 6 2 1
R:R:C114 R:R:N84 4.72 0 No No 4 6 2 1
L:L:?1 R:R:N84 6.74 3 Yes No 0 6 0 1
L:L:?1 R:R:G85 4.2 3 Yes No 0 7 0 1
R:R:T184 R:R:Y92 14.98 3 Yes Yes 9 8 1 1
L:L:?1 R:R:Y92 6.47 3 Yes Yes 0 8 0 1
R:R:K96 R:R:T184 4.5 0 No Yes 5 9 2 1
R:R:F111 R:R:M115 4.98 0 No Yes 6 8 2 1
R:R:F187 R:R:M115 4.98 3 Yes Yes 8 8 1 1
R:R:L290 R:R:M115 4.24 3 Yes Yes 7 8 1 1
L:L:?1 R:R:M115 11.27 3 Yes Yes 0 8 0 1
R:R:F187 R:R:V116 5.24 3 Yes Yes 8 8 1 2
R:R:V116 R:R:Y188 11.36 3 Yes Yes 8 6 2 2
L:L:?1 R:R:S118 3.68 3 Yes No 0 7 0 1
R:R:L123 R:R:W262 21.64 0 No Yes 7 9 2 1
R:R:Q180 R:R:W185 13.14 3 No Yes 8 8 2 1
R:R:F187 R:R:Q180 3.51 3 Yes No 8 8 1 2
R:R:S182 R:R:T184 6.4 3 No Yes 8 9 2 1
R:R:S182 R:R:W185 4.94 3 No Yes 8 8 2 1
R:R:T184 R:R:W185 4.85 3 Yes Yes 9 8 1 1
L:L:?1 R:R:T184 8.14 3 Yes Yes 0 9 0 1
R:R:F187 R:R:W185 7.02 3 Yes Yes 8 8 1 1
R:R:L290 R:R:W185 5.69 3 Yes Yes 7 8 1 1
L:L:?1 R:R:W185 4.89 3 Yes Yes 0 8 0 1
R:R:F187 R:R:Y188 10.32 3 Yes Yes 8 6 1 2
L:L:?1 R:R:F187 5.23 3 Yes Yes 0 8 0 1
R:R:L266 R:R:W262 5.69 0 No Yes 7 9 2 1
R:R:A293 R:R:W262 7.78 0 No Yes 8 9 2 1
R:R:N296 R:R:W262 10.17 3 No Yes 9 9 2 1
R:R:Q297 R:R:W262 4.38 3 Yes Yes 8 9 2 1
L:L:?1 R:R:W262 3.49 3 Yes Yes 0 9 0 1
R:R:F265 R:R:M269 7.46 3 Yes No 8 7 1 2
R:R:A289 R:R:F265 4.16 0 No Yes 7 8 2 1
R:R:F265 R:R:L290 3.65 3 Yes Yes 8 7 1 1
L:L:?1 R:R:F265 4.48 3 Yes Yes 0 8 0 1
R:R:L287 R:R:R291 9.72 0 No No 6 8 1 2
L:L:?1 R:R:L287 4.25 3 Yes No 0 6 0 1
L:L:?1 R:R:L290 6.79 3 Yes Yes 0 7 0 1
L:L:?1 R:R:T294 5.43 3 Yes No 0 9 0 1
R:R:N296 R:R:Q297 5.28 3 No Yes 9 8 2 2
L:L:?1 R:R:G119 3.15 3 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub8.00
Average Interaction Strength6.59
Average Nodes In Shell37.00
Average Hubs In Shell12.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell43.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XJM A Lipid Prostanoid FP-alpha Homo Sapiens Latanoprost - chim(NtGi2-Gs-CtGq)/Beta1/Gamma2 2.85 2024-02-28 To be published

A 2D representation of the interactions of 7WT in 8XJM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F32 R:R:R27 7.48 1 No No 4 2 2 2
R:R:R27 R:R:R291 5.33 1 No Yes 2 8 2 1
R:R:L28 R:R:Y92 3.52 0 No Yes 4 8 2 1
R:R:L28 R:R:L287 4.15 0 No No 4 6 2 2
R:R:V30 R:R:Y92 11.36 0 No Yes 6 8 2 1
R:R:F32 R:R:R291 13.9 1 No Yes 4 8 2 1
R:R:A88 R:R:S33 3.42 1 No No 8 7 1 1
L:L:?1 R:R:S33 5.93 1 Yes No 0 7 0 1
R:R:F36 R:R:R291 3.21 1 Yes Yes 8 8 2 1
R:R:F36 R:R:T294 6.49 1 Yes No 8 9 2 1
R:R:F36 R:R:W295 14.03 1 Yes No 8 5 2 2
R:R:F36 R:R:I298 3.77 1 Yes Yes 8 8 2 2
R:R:G40 R:R:H81 9.53 0 No Yes 9 8 2 1
R:R:D77 R:R:P122 6.44 1 Yes No 9 9 2 2
R:R:D77 R:R:Q297 7.83 1 Yes Yes 9 8 2 1
R:R:H81 R:R:Q297 3.71 1 Yes Yes 8 8 1 1
R:R:H81 R:R:I298 5.3 1 Yes Yes 8 8 1 2
L:L:?1 R:R:H81 7.61 1 Yes Yes 0 8 0 1
R:R:F111 R:R:N84 4.83 1 Yes Yes 6 6 2 2
R:R:M115 R:R:N84 7.01 1 No Yes 8 6 1 2
L:L:?1 R:R:A88 4.15 1 Yes No 0 8 0 1
R:R:K96 R:R:Y92 5.97 1 No Yes 5 8 2 1
R:R:T184 R:R:Y92 8.74 1 Yes Yes 9 8 1 1
L:L:?1 R:R:Y92 6.94 1 Yes Yes 0 8 0 1
R:R:K96 R:R:T184 4.5 1 No Yes 5 9 2 1
R:R:F111 R:R:M115 4.98 1 Yes No 6 8 2 1
L:L:?1 R:R:M115 7.44 1 Yes No 0 8 0 1
L:L:?1 R:R:G119 3.37 1 Yes No 0 7 0 1
R:R:P122 R:R:Q297 9.47 1 No Yes 9 8 2 1
R:R:L123 R:R:W262 22.78 0 No Yes 7 9 2 1
R:R:T184 R:R:W185 6.06 1 Yes Yes 9 8 1 2
L:L:?1 R:R:T184 5.82 1 Yes Yes 0 9 0 1
R:R:F187 R:R:W185 9.02 1 Yes Yes 8 8 2 2
R:R:F265 R:R:W185 4.01 1 Yes Yes 8 8 1 2
R:R:L290 R:R:W185 14.81 1 No Yes 7 8 1 2
R:R:F187 R:R:F265 5.36 1 Yes Yes 8 8 2 1
R:R:F265 R:R:W262 4.01 1 Yes Yes 8 9 1 1
R:R:L266 R:R:W262 5.69 0 No Yes 7 9 2 1
R:R:A293 R:R:W262 9.08 0 No Yes 8 9 2 1
R:R:N296 R:R:W262 10.17 1 Yes Yes 9 9 2 1
R:R:Q297 R:R:W262 7.67 1 Yes Yes 8 9 1 1
L:L:?1 R:R:W262 8.24 1 Yes Yes 0 9 0 1
R:R:F265 R:R:M269 9.95 1 Yes No 8 7 1 2
R:R:F265 R:R:L290 6.09 1 Yes No 8 7 1 1
L:L:?1 R:R:F265 8.01 1 Yes Yes 0 8 0 1
R:R:L287 R:R:R291 9.72 0 No Yes 6 8 2 1
L:L:?1 R:R:L290 5.46 1 Yes No 0 7 0 1
L:L:?1 R:R:R291 4.79 1 Yes Yes 0 8 0 1
R:R:T294 R:R:W295 3.64 1 No No 9 5 1 2
L:L:?1 R:R:T294 4.85 1 Yes No 0 9 0 1
R:R:I298 R:R:W295 15.27 1 Yes No 8 5 2 2
R:R:N296 R:R:Q297 7.92 1 Yes Yes 9 8 2 1
L:L:?1 R:R:Q297 6.13 1 Yes Yes 0 8 0 1
R:R:A289 R:R:F265 2.77 0 No Yes 7 8 2 1
R:R:S33 R:R:V89 1.62 1 No No 7 6 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength6.06
Average Nodes In Shell37.00
Average Hubs In Shell16.00
Average Links In Shell55.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub8.00
Average Interaction Strength6.31
Average Nodes In Shell37.33
Average Hubs In Shell14.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell47.67

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)