Code8IA
Name~{N},~{N}-dimethylcyclohexanamine
Synonyms
Identifier
FormulaC8 H17 N
Molecular Weight127.227
SMILES
PubChem7415
Formal Charge0
Total Atoms26
Total Chiral Atoms0
Total Bonds26
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ITF A Orphan Orphan TA9 Mus Musculus DMCHA - chim(NtGi1-Gs)/Beta1/Gamma2 3.46 2023-05-31 10.1038/s41586-023-06106-4

A 2D representation of the interactions of 8IA in 8ITF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D112 11.67 2 Yes No 0 6 0 1
L:L:?1 R:R:T113 7.92 2 Yes No 0 4 0 1
L:L:?1 R:R:F117 5.24 2 Yes No 0 5 0 1
L:L:?1 R:R:Y274 12.6 2 Yes Yes 0 6 0 1
L:L:?1 R:R:V297 4.81 2 Yes Yes 0 6 0 1
L:L:?1 R:R:V300 3.2 2 Yes No 0 7 0 1
L:L:?1 R:R:Y301 11.34 2 Yes Yes 0 8 0 1
R:R:D112 R:R:V85 7.3 2 No Yes 6 7 1 2
R:R:D112 R:R:Y301 13.79 2 No Yes 6 8 1 1
R:R:T113 R:R:Y163 7.49 2 No Yes 4 5 1 2
R:R:F168 R:R:T113 11.67 2 Yes No 5 4 2 1
R:R:F117 R:R:L205 4.87 0 No No 5 4 1 2
R:R:F117 R:R:W271 4.01 0 No Yes 5 8 1 2
R:R:F168 R:R:Y163 3.09 2 Yes Yes 5 5 2 2
R:R:V300 R:R:W271 3.68 2 No Yes 7 8 1 2
R:R:Y274 R:R:Y293 4.96 2 Yes No 6 4 1 2
R:R:V297 R:R:Y274 2.52 2 Yes Yes 6 6 1 1
R:R:V300 R:R:Y274 2.52 2 No Yes 7 6 1 1
R:R:V297 R:R:Y293 5.05 2 Yes No 6 4 1 2
R:R:V297 R:R:Y301 6.31 2 Yes Yes 6 8 1 1
R:R:W298 R:R:Y301 6.75 0 Yes Yes 5 8 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.11
Average Nodes In Shell15.00
Average Hubs In Shell9.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8PM2 A Amine Trace Amine Receptors TA7 Mus Musculus DMCH - Gs/Beta1/Gamma2 2.92 2023-08-09 doi.org/10.1101/2023.07.07.547762

A 2D representation of the interactions of 8IA in 8PM2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D127 24.81 2 Yes Yes 0 6 0 1
L:L:?1 R:R:V128 4.81 2 Yes No 0 4 0 1
L:L:?1 R:R:C131 5.12 2 Yes No 0 7 0 1
L:L:?1 R:R:Y132 5.04 2 Yes Yes 0 5 0 1
L:L:?1 R:R:N217 8.86 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W286 4.9 2 Yes Yes 0 8 0 1
L:L:?1 R:R:Y289 15.12 2 Yes Yes 0 6 0 1
L:L:?1 R:R:V312 11.21 2 Yes No 0 5 0 1
L:L:?1 R:R:V315 8.01 2 Yes Yes 0 7 0 1
L:L:?1 R:R:Y316 12.6 2 Yes Yes 0 7 0 1
R:R:D127 R:R:V100 4.38 2 Yes No 6 7 1 2
R:R:V100 R:R:Y316 5.05 2 No Yes 7 7 2 1
R:R:M101 R:R:Y316 3.59 2 Yes Yes 7 7 2 1
R:R:D127 R:R:V128 2.92 2 Yes No 6 4 1 1
R:R:C131 R:R:D127 4.67 2 No Yes 7 6 1 1
R:R:D127 R:R:Y316 9.2 2 Yes Yes 6 7 1 1
R:R:I183 R:R:V128 4.61 0 No No 5 4 2 1
R:R:F136 R:R:Y132 4.13 0 No Yes 5 5 2 1
R:R:N217 R:R:Y132 6.98 2 Yes Yes 6 5 1 1
R:R:V220 R:R:Y132 5.05 0 No Yes 5 5 2 1
R:R:F221 R:R:Y132 3.09 2 Yes Yes 8 5 2 1
R:R:W286 R:R:Y132 6.75 2 Yes Yes 8 5 1 1
R:R:F290 R:R:Y132 4.13 2 Yes Yes 7 5 2 1
R:R:N217 R:R:Y178 4.65 2 Yes Yes 6 5 1 2
R:R:V220 R:R:Y178 7.57 0 No Yes 5 5 2 2
R:R:N217 R:R:W213 12.43 2 Yes No 6 7 1 2
R:R:F290 R:R:N217 4.83 2 Yes Yes 7 6 2 1
R:R:F221 R:R:W286 14.03 2 Yes Yes 8 8 2 1
R:R:F221 R:R:F290 18.22 2 Yes Yes 8 7 2 2
R:R:S285 R:R:W286 6.18 2 No Yes 8 8 2 1
R:R:N318 R:R:S285 5.96 2 No No 9 8 2 2
R:R:F290 R:R:W286 5.01 2 Yes Yes 7 8 2 1
R:R:V315 R:R:W286 7.36 2 Yes Yes 7 8 1 1
R:R:N318 R:R:W286 6.78 2 No Yes 9 8 2 1
R:R:Y289 R:R:Y308 7.94 2 Yes No 6 3 1 2
R:R:L311 R:R:Y289 3.52 0 No Yes 5 6 2 1
R:R:V315 R:R:Y289 3.79 2 Yes Yes 7 6 1 1
R:R:V312 R:R:Y308 5.05 2 No No 5 3 1 2
R:R:V312 R:R:Y316 3.79 2 No Yes 5 7 1 1
R:R:V96 R:R:Y316 2.52 0 No Yes 7 7 2 1
R:R:I314 R:R:V315 1.54 0 No Yes 7 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.05
Average Nodes In Shell26.00
Average Hubs In Shell12.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.50
Average Number Of Links With An Hub4.50
Average Interaction Strength9.08
Average Nodes In Shell20.50
Average Hubs In Shell9.50
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell27.25

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)