Code8TZ
Name(~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol
Synonyms
Identifier(~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol
FormulaC13 H15 F N2 O
Molecular Weight234.269
SMILESCCCc1cc(ccc1[C@@H](c2[nH]ccn2)O)F
PubChem126961334
Formal Charge0
Total Atoms32
Total Chiral Atoms1
Total Bonds33
Total Aromatic Bonds11
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NDD A Peptide Proteinase-activated PAR2 Homo sapiens - AZ8838; Na - 2.8 2017-05-03 10.1038/nature22309

A 2D representation of the interactions of 8TZ in 5NDD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L78 R:R:Y82 4.69 1 No Yes 5 7 2 1
R:R:H135 R:R:L78 9 1 Yes No 5 5 1 2
R:R:I327 R:R:L78 4.28 0 No No 4 5 1 2
R:R:H135 R:R:P79 4.58 1 Yes No 5 5 1 2
R:R:F128 R:R:Y82 5.16 1 Yes Yes 8 7 2 1
R:R:K131 R:R:Y82 19.11 1 No Yes 7 7 1 1
R:R:H135 R:R:Y82 4.36 1 Yes Yes 5 7 1 1
R:R:C331 R:R:Y82 9.41 0 No Yes 6 7 2 1
R:R:T334 R:R:Y82 6.24 1 No Yes 7 7 2 1
R:R:Y82 W:W:?1 8.75 1 Yes Yes 7 0 1 0
R:R:F128 R:R:K131 9.93 1 Yes No 8 7 2 1
R:R:F128 R:R:T334 6.49 1 Yes No 8 7 2 2
R:R:K131 W:W:?1 7.65 1 No Yes 7 0 1 0
R:R:H135 R:R:Y134 10.89 1 Yes Yes 5 5 1 1
R:R:N139 R:R:Y134 5.81 1 Yes Yes 5 5 2 1
R:R:W141 R:R:Y134 8.68 1 Yes Yes 9 5 2 1
R:R:C226 R:R:Y134 4.03 1 Yes Yes 9 5 1 1
R:R:D228 R:R:Y134 9.2 1 No Yes 4 5 1 1
R:R:Y134 W:W:?1 7.16 1 Yes Yes 5 0 1 0
R:R:H135 R:R:N139 6.38 1 Yes Yes 5 5 1 2
R:R:H135 W:W:?1 7.85 1 Yes Yes 5 0 1 0
R:R:C148 R:R:W141 5.22 1 No Yes 9 9 2 2
R:R:C226 R:R:W141 5.22 1 Yes Yes 9 9 1 2
R:R:C148 R:R:C226 7.28 1 No Yes 9 9 2 1
R:R:I152 R:R:Q214 5.49 1 No No 5 4 1 2
R:R:H227 R:R:I152 9.28 1 Yes No 5 5 1 1
R:R:I152 W:W:?1 4.84 1 No Yes 5 0 1 0
R:R:F155 R:R:Y156 14.44 1 No Yes 6 5 1 2
R:R:F155 R:R:L330 3.65 1 No Yes 6 5 1 1
R:R:F155 W:W:?1 15.7 1 No Yes 6 0 1 0
R:R:H227 R:R:Y156 8.71 1 Yes Yes 5 5 1 2
R:R:C226 W:W:?1 6.46 1 Yes Yes 9 0 1 0
R:R:H227 R:R:Y326 4.36 1 Yes Yes 5 4 1 2
R:R:H227 R:R:L330 3.86 1 Yes Yes 5 5 1 1
R:R:H227 W:W:?1 24.42 1 Yes Yes 5 0 1 0
R:R:D228 W:W:?1 8.29 1 No Yes 4 0 1 0
R:R:I327 R:R:Y323 7.25 0 No Yes 4 4 1 2
R:R:L330 R:R:Y326 9.38 1 Yes Yes 5 4 1 2
R:R:I327 W:W:?1 5.81 0 No Yes 4 0 1 0
R:R:L330 W:W:?1 8.45 1 Yes Yes 5 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.58
Average Nodes In Shell24.00
Average Hubs In Shell13.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.58
Average Nodes In Shell24.00
Average Hubs In Shell13.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell38.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)