| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7WC5 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo Sapiens | Psilocin | - | - | 3.2 | 2022-01-26 | doi.org/10.1126/science.abl8615 |
|
A 2D representation of the interactions of 91Q in 7WC5
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:W151 | 6.94 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:D155 | 19.3 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V156 | 4.54 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:L228 | 9.84 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:F339 | 17.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N343 | 5.58 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N363 | 5.58 | 1 | Yes | No | 0 | 4 | 0 | 1 | | R:R:D155 | R:R:V127 | 7.3 | 1 | No | No | 8 | 8 | 1 | 2 | | R:R:V127 | R:R:Y370 | 3.79 | 1 | No | Yes | 8 | 7 | 2 | 2 | | R:R:V130 | R:R:W151 | 14.71 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:N363 | R:R:Y139 | 22.1 | 0 | No | Yes | 4 | 3 | 1 | 2 | | R:R:W141 | R:R:W151 | 8.43 | 1 | Yes | Yes | 7 | 5 | 2 | 1 | | R:R:C227 | R:R:W141 | 10.45 | 1 | No | Yes | 9 | 7 | 2 | 2 | | R:R:C227 | R:R:W151 | 5.22 | 1 | No | Yes | 9 | 5 | 2 | 1 | | R:R:D155 | R:R:Y370 | 5.75 | 1 | No | Yes | 8 | 7 | 1 | 2 | | R:R:S207 | R:R:V156 | 4.85 | 0 | No | No | 7 | 6 | 2 | 1 | | R:R:I210 | R:R:V156 | 4.61 | 0 | No | No | 6 | 6 | 2 | 1 | | R:R:K223 | R:R:L228 | 4.23 | 0 | No | Yes | 3 | 4 | 2 | 1 | | R:R:N343 | R:R:V235 | 4.43 | 1 | Yes | No | 7 | 6 | 1 | 2 | | R:R:F339 | R:R:W336 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F339 | R:R:N343 | 9.67 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:F339 | R:R:L362 | 6.09 | 1 | Yes | No | 7 | 3 | 1 | 2 | | R:R:F339 | R:R:V366 | 5.24 | 1 | Yes | No | 7 | 6 | 1 | 2 | | R:R:L362 | R:R:N343 | 8.24 | 1 | No | Yes | 3 | 7 | 2 | 1 | | R:R:V366 | R:R:Y370 | 7.57 | 0 | No | Yes | 6 | 7 | 2 | 2 | | R:R:A230 | R:R:L228 | 1.58 | 0 | No | Yes | 3 | 4 | 2 | 1 | | R:R:L228 | R:R:S226 | 1.5 | 0 | Yes | No | 4 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 9.87 | | Average Nodes In Shell | 23.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 27.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8DPG | A | Amine | 5-Hydroxytryptamine | 5-HT2C | Homo Sapiens | Psilocin | - | chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 | 3.6 | 2022-08-24 | doi.org/10.1016/j.celrep.2022.111211 |
|
A 2D representation of the interactions of 91Q in 8DPG
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D134 | 15.17 | 12 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V135 | 22.7 | 12 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S138 | 9.15 | 12 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:T139 | 2.99 | 12 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F214 | 8.66 | 12 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:G218 | 3.48 | 12 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:S219 | 12.2 | 12 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:A222 | 4.8 | 12 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F327 | 4.95 | 12 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y358 | 2.38 | 12 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:D134 | R:R:V106 | 13.15 | 12 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:V106 | R:R:Y358 | 5.05 | 12 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:M107 | R:R:Y358 | 2.39 | 0 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:D134 | R:R:S138 | 2.94 | 12 | Yes | No | 8 | 6 | 1 | 1 | | R:R:D134 | R:R:Y358 | 10.34 | 12 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:V135 | R:R:V185 | 3.21 | 0 | No | No | 6 | 6 | 1 | 2 | | R:R:M143 | R:R:T139 | 3.01 | 0 | Yes | Yes | 6 | 7 | 2 | 1 | | R:R:S182 | R:R:T139 | 3.2 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:T139 | R:R:V185 | 4.76 | 0 | Yes | No | 7 | 6 | 1 | 2 | | R:R:F214 | R:R:L209 | 7.31 | 0 | No | No | 7 | 5 | 1 | 2 | | R:R:G218 | R:R:I217 | 3.53 | 0 | No | No | 7 | 4 | 1 | 2 | | R:R:F328 | R:R:S219 | 2.64 | 0 | No | No | 7 | 7 | 2 | 1 | | R:R:F327 | R:R:F328 | 4.29 | 0 | Yes | No | 7 | 7 | 1 | 2 | | R:R:F327 | R:R:L350 | 2.44 | 0 | Yes | No | 7 | 4 | 1 | 2 | | R:R:F327 | R:R:V354 | 7.87 | 0 | Yes | No | 7 | 7 | 1 | 2 | | R:R:V354 | R:R:Y358 | 5.05 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:W355 | R:R:Y358 | 3.86 | 0 | Yes | Yes | 7 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 8.65 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 27.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9AS7 | A | Amine | 5-Hydroxytryptamine | 5-HT2A | Homo Sapiens | Psilocin | - | - | 2.72 | 2025-04-02 | doi.org/10.1038/s41467-025-57956-7 |
|
A 2D representation of the interactions of 91Q in 9AS7
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D155 | 15.17 | 1 | Yes | No | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:V156 | 16.65 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S159 | 12.2 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F234 | 3.71 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:S239 | 4.58 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S242 | 6.1 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F339 | 11.14 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F340 | 12.37 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:D155 | R:R:V127 | 7.3 | 1 | No | Yes | 8 | 8 | 1 | 2 | | R:R:V127 | R:R:Y370 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 2 | | R:R:D155 | R:R:Y370 | 11.49 | 1 | No | Yes | 8 | 7 | 1 | 2 | | R:R:I210 | R:R:V156 | 4.61 | 0 | Yes | No | 6 | 6 | 2 | 1 | | R:R:S159 | R:R:W336 | 4.94 | 0 | No | Yes | 7 | 8 | 1 | 2 | | R:R:F234 | R:R:I210 | 5.02 | 0 | Yes | Yes | 7 | 6 | 1 | 2 | | R:R:D231 | R:R:F234 | 4.78 | 0 | No | Yes | 5 | 7 | 2 | 1 | | R:R:F340 | R:R:S239 | 3.96 | 1 | Yes | No | 7 | 6 | 1 | 1 | | R:R:F243 | R:R:W336 | 7.02 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F243 | R:R:F340 | 22.51 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F339 | R:R:W336 | 4.01 | 0 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F340 | R:R:W336 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F339 | R:R:L362 | 3.65 | 0 | Yes | No | 7 | 3 | 1 | 2 | | R:R:F339 | R:R:V366 | 7.87 | 0 | Yes | No | 7 | 6 | 1 | 2 | | R:R:V366 | R:R:Y370 | 5.05 | 0 | No | Yes | 6 | 7 | 2 | 2 | | R:R:I344 | R:R:S239 | 3.1 | 0 | No | No | 5 | 6 | 2 | 1 | | R:R:F234 | R:R:P209 | 2.89 | 0 | Yes | No | 7 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.24 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 25.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
