Code9HO
Name9(S)-HODE
Synonyms
  • 9(S)-HODE
  • 9S-Hode
  • alpha-Dimorphecolic acid
  • (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
Identifier(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
FormulaC18 H32 O3
Molecular Weight296.445
SMILESCCCCC\C=C/C=C/[C@H](CCCCCCCC(=O)O)O
PubChem5312830
Formal Charge0
Total Atoms53
Total Chiral Atoms1
Total Bonds52
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HQN A Orphan A orphans GPR132 Homo Sapiens 9(S)-HODE - Gi1/Beta1/Gamma2 3 2023-10-11 0.1038/s42255-023-00899-4

A 2D representation of the interactions of 9HO in 8HQN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:A119 R:R:F123 2.77 0 No Yes 6 5 2 1
R:R:F122 R:R:F123 7.5 0 Yes Yes 6 5 2 1
R:R:F123 R:R:H174 5.66 3 Yes Yes 5 6 1 1
L:L:?1 R:R:F123 18.93 3 Yes Yes 0 5 0 1
R:R:V170 R:R:Y127 5.05 0 No Yes 7 8 2 1
R:R:R203 R:R:Y127 2.06 3 Yes Yes 5 8 1 1
R:R:F208 R:R:Y127 8.25 3 Yes Yes 8 8 2 1
L:L:?1 R:R:Y127 4.05 3 Yes Yes 0 8 0 1
R:R:H174 R:R:V170 2.77 3 Yes No 6 7 1 2
R:R:R203 R:R:V173 3.92 3 Yes No 5 5 1 2
R:R:H174 R:R:V177 4.15 3 Yes No 6 5 1 1
L:L:?1 R:R:H174 11.84 3 Yes Yes 0 6 0 1
R:R:R203 R:R:V177 6.54 3 Yes No 5 5 1 1
L:L:?1 R:R:V177 2.57 3 Yes No 0 5 0 1
R:R:F269 R:R:L190 4.87 3 Yes Yes 4 4 2 1
R:R:D275 R:R:L190 4.07 3 No Yes 2 4 2 1
R:R:E283 R:R:L190 13.25 0 No Yes 3 4 2 1
L:L:?1 R:R:L190 6.37 3 Yes Yes 0 4 0 1
R:R:A197 R:R:K265 3.21 0 No No 4 5 2 1
R:R:R203 R:R:Y199 5.14 3 Yes No 5 4 1 2
R:R:R203 R:R:Y200 5.14 3 Yes Yes 5 5 1 1
R:R:Y200 R:R:Y258 3.97 3 Yes Yes 5 7 1 1
R:R:L262 R:R:Y200 14.07 3 No Yes 6 5 2 1
L:L:?1 R:R:Y200 18.22 3 Yes Yes 0 5 0 1
L:L:?1 R:R:R203 9.79 3 Yes Yes 0 5 0 1
R:R:L262 R:R:Y258 15.24 3 No Yes 6 7 2 1
R:R:F293 R:R:Y258 5.16 0 Yes Yes 7 7 2 1
L:L:?1 R:R:Y258 2.7 3 Yes Yes 0 7 0 1
R:R:F269 R:R:K265 8.69 3 Yes No 4 5 2 1
L:L:?1 R:R:K265 8.93 3 Yes No 0 5 0 1
R:R:D275 R:R:F269 8.36 3 No Yes 2 4 2 2
R:R:L282 R:R:L286 2.77 0 No No 1 4 2 1
R:R:L286 R:R:R285 8.5 0 No No 4 2 1 2
L:L:?1 R:R:L286 5.58 3 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.90
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.90
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell31.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)