psnGPCR

Code	9UJ
Name	(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	TUG-1375
Identifier
Formula	C22 H19 Cl N2 O4 S
Molecular Weight	442.915
SMILES
PubChem	138319694
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	17
Networks	12

This ligand is also present in the following 12 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J22

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

Gi1/Beta1/Gamma2

3.2

2024-01-24

doi.org/10.1038/s41422-023-00914-z

A 2D representation of the interactions of 9UJ in 8J22
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F89	R:R:K65	13.65	2	Yes	Yes	7	7	2	2
R:R:K65	R:R:Y90	4.78	2	Yes	Yes	7	5	2	1
R:R:F87	R:R:G88	4.52	0	Yes	No	6	5	1	2
R:R:F138	R:R:F87	6.43	0	No	Yes	3	6	2	1
R:R:C141	R:R:F87	2.79	0	No	Yes	7	6	2	1
R:R:F87	R:R:T142	2.59	0	Yes	No	6	4	1	2
R:R:F89	R:R:Y90	3.09	2	Yes	Yes	7	5	2	1
R:R:F89	R:R:V259	2.62	2	Yes	Yes	7	5	2	2
R:R:I93	R:R:Y90	2.42	2	Yes	Yes	8	5	2	1
R:R:E166	R:R:Y90	3.37	2	Yes	Yes	5	5	1	1
R:R:Y238	R:R:Y90	9.93	2	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	2.06	2	Yes	Yes	5	5	1	1
R:R:V259	R:R:Y90	8.83	2	Yes	Yes	5	5	2	1
L:L:?1	R:R:Y90	7.55	2	Yes	Yes	0	5	0	1
R:R:I93	R:R:Y238	3.63	2	Yes	Yes	8	7	2	1
R:R:I93	R:R:S262	6.19	2	Yes	No	8	8	2	2
R:R:L183	R:R:Y94	5.86	2	Yes	Yes	5	8	1	2
R:R:L187	R:R:Y94	8.21	2	Yes	Yes	6	8	2	2
R:R:Y238	R:R:Y94	5.96	2	Yes	Yes	7	8	1	2
R:R:N239	R:R:Y94	5.81	2	Yes	Yes	8	8	2	2
R:R:H242	R:R:Y94	3.27	0	Yes	Yes	6	8	2	2
R:R:E182	R:R:H140	9.85	2	No	Yes	4	4	2	2
R:R:H140	R:R:L183	3.86	2	Yes	Yes	4	5	2	1
R:R:H140	R:R:L187	10.29	2	Yes	Yes	4	6	2	2
L:L:?1	R:R:V144	11.73	2	Yes	No	0	5	0	1
R:R:I145	R:R:N160	8.5	0	No	Yes	4	5	1	2
L:L:?1	R:R:I145	4.09	2	Yes	No	0	4	0	1
R:R:N151	R:R:V147	2.96	0	No	No	5	4	2	1
L:L:?1	R:R:V147	5.33	2	Yes	No	0	4	0	1
R:R:N160	R:R:Q148	18.49	2	Yes	Yes	5	5	2	1
R:R:I162	R:R:Q148	9.61	2	Yes	Yes	4	5	2	1
R:R:Q148	R:R:T163	5.67	2	Yes	Yes	5	4	1	1
L:L:?1	R:R:Q148	22.87	2	Yes	Yes	0	5	0	1
R:R:I162	R:R:N160	4.25	2	Yes	Yes	4	5	2	2
R:R:I162	R:R:T163	3.04	2	Yes	Yes	4	4	2	1
R:R:E166	R:R:T163	4.23	2	Yes	Yes	5	4	1	1
R:R:F168	R:R:T163	2.59	2	Yes	Yes	4	4	1	1
L:L:?1	R:R:T163	6.33	2	Yes	Yes	0	4	0	1
R:R:E166	R:R:F168	2.33	2	Yes	Yes	5	4	1	1
R:R:E166	R:R:R255	5.82	2	Yes	Yes	5	5	1	1
L:L:?1	R:R:E166	2.85	2	Yes	Yes	0	5	0	1
R:R:F168	R:R:Q172	10.54	2	Yes	No	4	1	1	1
R:R:F168	R:R:L173	2.44	2	Yes	No	4	1	1	2
L:L:?1	R:R:F168	3.49	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q172	4.76	2	Yes	No	0	1	0	1
L:L:?1	R:R:V175	6.4	2	Yes	No	0	3	0	1
R:R:L177	R:R:V176	2.98	0	No	No	2	4	2	1
R:R:R180	R:R:V176	6.54	2	Yes	No	5	4	1	1
L:L:?1	R:R:V176	8.53	2	Yes	No	0	4	0	1
L:L:?1	R:R:V179	5.33	2	Yes	No	0	4	0	1
R:R:H242	R:R:R180	14.67	0	Yes	Yes	6	5	2	1
R:R:R180	R:R:S251	5.27	2	Yes	No	5	4	1	2
R:R:R180	R:R:R255	14.93	2	Yes	Yes	5	5	1	1
L:L:?1	R:R:R180	7.83	2	Yes	Yes	0	5	0	1
R:R:E182	R:R:L183	2.65	2	No	Yes	4	5	2	1
R:R:L183	R:R:L187	4.15	2	Yes	Yes	5	6	1	2
L:L:?1	R:R:L183	1.98	2	Yes	Yes	0	5	0	1
R:R:N239	R:R:Y238	4.65	2	Yes	Yes	8	7	2	1
R:R:R255	R:R:Y238	5.14	2	Yes	Yes	5	7	1	1
R:R:V259	R:R:Y238	2.52	2	Yes	Yes	5	7	2	1
R:R:S262	R:R:Y238	3.82	2	No	Yes	8	7	2	1
L:L:?1	R:R:Y238	4.2	2	Yes	Yes	0	7	0	1
R:R:H242	R:R:S241	2.79	0	Yes	Yes	6	5	2	2
R:R:P252	R:R:S241	5.34	2	Yes	Yes	1	5	2	2
R:R:R255	R:R:S241	3.95	2	Yes	Yes	5	5	1	2
R:R:P252	R:R:S251	3.56	2	Yes	No	1	4	2	2
R:R:P252	R:R:R255	5.76	2	Yes	Yes	1	5	2	1
L:L:?1	R:R:R255	4.35	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F87	1.74	2	Yes	Yes	0	6	0	1
R:R:I146	R:R:V147	1.54	0	No	No	4	4	2	1

Statistics	Value
Average Number Of Links	17.00
Average Number Of Links With An Hub	10.00
Average Interaction Strength	6.43
Average Nodes In Shell	42.00
Average Hubs In Shell	24.00
Average Links In Shell	70.00
Average Links Mediated by Hubs In Shell	67.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9NS9

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

Compound 187

Gi1/Beta1/Gamma2

3.3

2025-06-25

doi.org/10.1038/s41586-025-09186-6

A 2D representation of the interactions of 9UJ in 9NS9
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S86	4.3	9	Yes	No	0	6	0	1
L:L:?1	R:R:F87	4.36	9	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y90	24.34	9	Yes	No	0	5	0	1
L:L:?1	R:R:C141	5.68	9	Yes	No	0	7	0	1
L:L:?1	R:R:V144	11.73	9	Yes	No	0	5	0	1
L:L:?1	R:R:I145	7.15	9	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	28.58	9	Yes	No	0	5	0	1
L:L:?1	R:R:Y165	9.23	9	Yes	No	0	4	0	1
L:L:?1	R:R:Q172	4.76	9	Yes	Yes	0	1	0	1
L:L:?1	R:R:V176	10.66	9	Yes	No	0	4	0	1
L:L:?1	R:R:V179	4.27	9	Yes	No	0	4	0	1
L:L:?1	R:R:R180	9.57	9	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	3.96	9	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	4.2	9	Yes	Yes	0	7	0	1
L:L:?1	R:R:R255	3.48	9	Yes	Yes	0	5	0	1
R:R:A83	R:R:Y165	4	0	No	No	7	4	2	1
R:R:F87	R:R:G88	4.52	0	Yes	No	6	5	1	2
R:R:F138	R:R:F87	3.22	0	No	Yes	3	6	2	1
R:R:F87	R:R:T142	3.89	0	Yes	No	6	4	1	2
R:R:Y238	R:R:Y90	10.92	9	Yes	No	7	5	1	1
R:R:R255	R:R:Y90	10.29	9	Yes	No	5	5	1	1
R:R:F138	R:R:S91	17.18	0	No	No	3	5	2	2
R:R:C141	R:R:S91	5.16	0	No	No	7	5	1	2
R:R:L183	R:R:Y94	5.86	9	No	Yes	5	8	1	2
R:R:L187	R:R:Y94	10.55	9	Yes	Yes	6	8	2	2
R:R:Y238	R:R:Y94	5.96	9	Yes	Yes	7	8	1	2
R:R:H242	R:R:Y94	3.27	9	Yes	Yes	6	8	2	2
R:R:Q148	R:R:Y165	9.02	9	No	No	5	4	1	1
R:R:Q148	R:R:Q172	3.84	9	No	Yes	5	1	1	1
R:R:F168	R:R:Q172	8.2	0	No	Yes	4	1	2	1
R:R:Q172	R:R:T169	11.34	9	Yes	No	1	4	1	2
R:R:R180	R:R:V176	6.54	9	Yes	No	5	4	1	1
R:R:H242	R:R:R180	13.54	9	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	15.99	9	Yes	Yes	5	5	1	1
R:R:L183	R:R:L187	5.54	9	No	Yes	5	6	1	2
R:R:H242	R:R:Y238	7.62	9	Yes	Yes	6	7	2	1
R:R:R255	R:R:Y238	14.4	9	Yes	Yes	5	7	1	1
R:R:A258	R:R:Y238	4	0	No	Yes	7	7	2	1
L:L:?1	R:R:V147	2.13	9	Yes	No	0	4	0	1
R:R:S86	R:R:T85	1.6	0	No	No	6	5	1	2

Statistics	Value
Average Number Of Links	16.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	8.65
Average Nodes In Shell	29.00
Average Hubs In Shell	9.00
Average Links In Shell	40.00
Average Links Mediated by Hubs In Shell	35.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8Y6W

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

4-CMTB

Gi1/Beta1/Gamma2

3.19

2025-04-02

doi.org/10.1038/s41467-025-57983-4

A 2D representation of the interactions of 9UJ in 8Y6W
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S86	R:R:Y165	5.09	0	No	Yes	6	4	2	1
R:R:F87	R:R:S91	7.93	1	Yes	No	6	5	2	2
R:R:C141	R:R:F87	4.19	1	No	Yes	7	6	1	2
R:R:F89	R:R:Y90	3.09	0	Yes	Yes	7	5	2	1
R:R:Y238	R:R:Y90	5.96	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	4.12	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:Y90	14.27	1	Yes	Yes	0	5	0	1
R:R:C141	R:R:S91	5.16	1	No	No	7	5	1	2
R:R:I93	R:R:Y238	3.63	1	No	Yes	8	7	2	1
R:R:I93	R:R:S262	4.64	1	No	No	8	8	2	2
R:R:Y238	R:R:Y94	11.91	1	Yes	Yes	7	8	1	2
R:R:H242	R:R:Y94	4.36	1	Yes	Yes	6	8	2	2
R:R:H140	R:R:L183	5.14	0	No	No	4	5	2	1
L:L:?1	R:R:C141	3.41	1	Yes	No	0	7	0	1
R:R:V144	R:R:V179	3.21	1	No	No	5	4	1	1
L:L:?1	R:R:V144	9.6	1	Yes	No	0	5	0	1
L:L:?1	R:R:V147	3.2	1	Yes	No	0	4	0	1
R:R:Q148	R:R:Y165	10.15	1	No	Yes	5	4	1	1
L:L:?1	R:R:Q148	4.76	1	Yes	No	0	5	0	1
R:R:F168	R:R:Y165	5.16	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:Y165	7.55	1	Yes	Yes	0	4	0	1
R:R:E166	R:R:R255	6.98	0	No	Yes	5	5	2	1
R:R:F168	R:R:Q172	4.68	1	Yes	No	4	1	1	2
R:R:F168	R:R:V176	13.11	1	Yes	Yes	4	4	1	1
R:R:F168	R:R:R180	4.28	1	Yes	Yes	4	5	1	1
L:L:?1	R:R:F168	6.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V175	7.46	1	Yes	No	0	3	0	1
R:R:R180	R:R:V176	7.85	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:V176	12.8	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:V179	3.2	1	Yes	No	0	4	0	1
R:R:H242	R:R:R180	10.16	1	Yes	Yes	6	5	2	1
R:R:R180	R:R:S251	5.27	1	Yes	No	5	4	1	2
R:R:R180	R:R:R255	18.13	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:R180	11.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	3.96	1	Yes	No	0	5	0	1
R:R:H242	R:R:Y238	9.8	1	Yes	Yes	6	7	2	1
R:R:R255	R:R:Y238	3.09	1	Yes	Yes	5	7	1	1
R:R:S262	R:R:Y238	3.82	1	No	Yes	8	7	2	1
L:L:?1	R:R:Y238	5.87	1	Yes	Yes	0	7	0	1
R:R:P252	R:R:S241	3.56	1	Yes	No	1	5	2	2
R:R:R255	R:R:S241	5.27	1	Yes	No	5	5	1	2
R:R:P252	R:R:S251	3.56	1	Yes	No	1	4	2	2
R:R:P252	R:R:R255	5.76	1	Yes	Yes	1	5	2	1
L:L:?1	R:R:R255	5.22	1	Yes	Yes	0	5	0	1
R:R:L177	R:R:V176	2.98	0	No	Yes	2	4	2	1

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	7.11
Average Nodes In Shell	30.00
Average Hubs In Shell	13.00
Average Links In Shell	45.00
Average Links Mediated by Hubs In Shell	41.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9CLW

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

4-CMTB

chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2

3.19

2025-06-25

doi.org/10.1038/s41586-025-09186-6

A 2D representation of the interactions of 9UJ in 9CLW
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	12.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V144	12.8	1	Yes	No	0	5	0	1
L:L:?1	R:R:I145	7.15	1	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	7.62	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y165	10.07	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q172	6.67	1	Yes	No	0	1	0	1
L:L:?1	R:R:V175	7.46	1	Yes	No	0	3	0	1
L:L:?1	R:R:V176	7.46	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R180	15.65	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	3.96	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	5.87	1	Yes	Yes	0	7	0	1
R:R:F89	R:R:K65	7.44	1	Yes	Yes	7	7	2	2
R:R:K65	R:R:Y90	3.58	1	Yes	Yes	7	5	2	1
R:R:A83	R:R:Y165	5.34	0	No	Yes	7	4	2	1
R:R:S86	R:R:Y90	3.82	0	No	Yes	6	5	2	1
R:R:F89	R:R:Y90	6.19	1	Yes	Yes	7	5	2	1
R:R:F89	R:R:I93	3.77	1	Yes	Yes	7	8	2	2
R:R:F89	R:R:V259	6.55	1	Yes	No	7	5	2	2
R:R:Y238	R:R:Y90	4.96	1	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	4.12	0	Yes	Yes	5	5	2	1
R:R:V259	R:R:Y90	6.31	1	No	Yes	5	5	2	1
R:R:I93	R:R:Y238	3.63	1	Yes	Yes	8	7	2	1
R:R:I93	R:R:S262	7.74	1	Yes	No	8	8	2	2
R:R:L183	R:R:Y94	5.86	0	No	Yes	5	8	1	2
R:R:Y238	R:R:Y94	10.92	1	Yes	Yes	7	8	1	2
R:R:N239	R:R:Y94	12.79	1	Yes	Yes	8	8	2	2
R:R:H242	R:R:Y94	7.62	1	Yes	Yes	6	8	2	2
R:R:H140	R:R:L183	6.43	0	No	No	4	5	2	1
R:R:I145	R:R:Q148	6.86	1	No	Yes	4	5	1	1
R:R:I145	R:R:Y165	4.84	1	No	Yes	4	4	1	1
R:R:Q148	R:R:Y149	4.51	1	Yes	No	5	5	1	2
R:R:Q148	R:R:Y165	6.76	1	Yes	Yes	5	4	1	1
R:R:F168	R:R:L173	3.65	1	No	No	4	1	2	2
R:R:F168	R:R:V176	9.18	1	No	Yes	4	4	2	1
R:R:N171	R:R:Q172	13.2	0	No	No	3	1	2	1
R:R:L173	R:R:V176	4.47	1	No	Yes	1	4	2	1
R:R:R180	R:R:V176	6.54	1	Yes	Yes	5	4	1	1
R:R:H242	R:R:R180	11.28	1	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	15.99	1	Yes	Yes	5	5	1	2
R:R:N239	R:R:Y238	4.65	1	Yes	Yes	8	7	2	1
R:R:H242	R:R:Y238	14.16	1	Yes	Yes	6	7	2	1
R:R:V259	R:R:Y238	5.05	1	No	Yes	5	7	2	1
R:R:S262	R:R:Y238	5.09	1	No	Yes	8	7	2	1
R:R:H242	R:R:N239	5.1	1	Yes	Yes	6	8	2	2
L:L:?1	R:R:V179	3.2	1	Yes	No	0	4	0	1
R:R:C82	R:R:Y165	2.69	0	No	Yes	9	4	2	1
L:L:?1	R:R:V147	2.13	1	Yes	No	0	4	0	1
R:R:I143	R:R:V147	1.54	0	No	No	7	4	2	1
R:R:N151	R:R:V147	1.48	0	No	No	5	4	2	1
R:R:A258	R:R:Y238	1.33	0	No	Yes	7	7	2	1

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	7.89
Average Nodes In Shell	34.00
Average Hubs In Shell	14.00
Average Links In Shell	50.00
Average Links Mediated by Hubs In Shell	45.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9CM3

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

Compound 187

chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2

3.06

2025-06-25

doi.org/10.1038/s41586-025-09186-6

A 2D representation of the interactions of 9UJ in 9CM3
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y90	17.62	6	Yes	Yes	0	5	0	1
L:L:?1	R:R:V144	16	6	Yes	No	0	5	0	1
L:L:?1	R:R:I145	4.09	6	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	19.06	6	Yes	No	0	5	0	1
L:L:?1	R:R:Y165	12.59	6	Yes	Yes	0	4	0	1
L:L:?1	R:R:V175	8.53	6	Yes	No	0	3	0	1
L:L:?1	R:R:V176	11.73	6	Yes	Yes	0	4	0	1
L:L:?1	R:R:V179	5.33	6	Yes	No	0	4	0	1
L:L:?1	R:R:R180	8.7	6	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	4.95	6	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	4.2	6	Yes	Yes	0	7	0	1
L:L:?1	R:R:R255	4.35	6	Yes	Yes	0	5	0	1
R:R:F89	R:R:Y90	6.19	0	Yes	Yes	7	5	2	1
R:R:Y238	R:R:Y90	7.94	6	Yes	Yes	7	5	1	1
R:R:R255	R:R:Y90	5.14	6	Yes	Yes	5	5	1	1
R:R:L187	R:R:Y94	11.72	0	Yes	No	6	8	2	2
R:R:Y238	R:R:Y94	8.94	6	Yes	No	7	8	1	2
R:R:N239	R:R:Y94	6.98	6	Yes	No	8	8	2	2
R:R:Q148	R:R:Y165	7.89	6	No	Yes	5	4	1	1
R:R:F168	R:R:Y165	5.16	0	No	Yes	4	4	2	1
R:R:R180	R:R:V176	7.85	6	Yes	Yes	5	4	1	1
R:R:H242	R:R:R180	15.8	0	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	13.86	6	Yes	Yes	5	5	1	1
R:R:L183	R:R:L187	4.15	0	No	Yes	5	6	1	2
R:R:N239	R:R:Y238	4.65	6	Yes	Yes	8	7	2	1
R:R:H242	R:R:Y238	8.71	0	Yes	Yes	6	7	2	1
R:R:S262	R:R:Y238	5.09	0	No	Yes	8	7	2	1
R:R:H242	R:R:S241	4.18	0	Yes	No	6	5	2	2
R:R:R255	R:R:S241	5.27	6	Yes	No	5	5	1	2
R:R:P252	R:R:R255	5.76	0	No	Yes	1	5	2	1
R:R:R180	R:R:S251	3.95	6	Yes	No	5	4	1	2
R:R:V259	R:R:Y90	3.79	6	No	Yes	5	5	2	1
R:R:V259	R:R:Y238	3.79	6	No	Yes	5	7	2	1
R:R:C141	R:R:S91	3.44	0	No	No	7	5	1	2
L:L:?1	R:R:C141	3.41	6	Yes	No	0	7	0	1
L:L:?1	R:R:V147	3.2	6	Yes	No	0	4	0	1
R:R:L173	R:R:V176	2.98	0	No	Yes	1	4	2	1
R:R:L177	R:R:V176	2.98	0	No	Yes	2	4	2	1
R:R:C141	R:R:F87	2.79	0	No	No	7	6	1	2
R:R:A83	R:R:Y165	2.67	0	No	Yes	7	4	2	1
R:R:S86	R:R:Y165	2.54	0	No	Yes	6	4	2	1
R:R:I143	R:R:V147	1.54	0	No	No	7	4	2	1
R:R:A258	R:R:Y238	1.33	0	No	Yes	7	7	2	1

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	8.84
Average Nodes In Shell	34.00
Average Hubs In Shell	11.00
Average Links In Shell	43.00
Average Links Mediated by Hubs In Shell	40.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9CM7

Lipid

Free Fatty Acid

FFA2

Homo Sapiens

TUG-1375

AZ-1729

Gi1/Beta1/Gamma2

3.29

2025-06-25

doi.org/10.1038/s41586-025-09186-6

A 2D representation of the interactions of 9UJ in 9CM7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F87	3.49	8	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y90	24.34	8	Yes	No	0	5	0	1
L:L:?1	R:R:C141	4.54	8	Yes	No	0	7	0	1
L:L:?1	R:R:V144	11.73	8	Yes	No	0	5	0	1
L:L:?1	R:R:I145	4.09	8	Yes	No	0	4	0	1
L:L:?1	R:R:Q148	12.39	8	Yes	No	0	5	0	1
L:L:?1	R:R:Y165	15.94	8	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q172	3.81	8	Yes	No	0	1	0	1
L:L:?1	R:R:V175	4.27	8	Yes	No	0	3	0	1
L:L:?1	R:R:V176	11.73	8	Yes	No	0	4	0	1
L:L:?1	R:R:V179	8.53	8	Yes	No	0	4	0	1
L:L:?1	R:R:R180	6.09	8	Yes	Yes	0	5	0	1
L:L:?1	R:R:L183	2.97	8	Yes	No	0	5	0	1
L:L:?1	R:R:Y238	4.2	8	Yes	Yes	0	7	0	1
L:L:?1	R:R:R255	3.48	8	Yes	Yes	0	5	0	1
R:R:A83	R:R:Y165	4	0	No	Yes	7	4	2	1
R:R:F87	R:R:G88	6.02	0	Yes	No	6	5	1	2
R:R:F138	R:R:F87	4.29	0	No	Yes	3	6	2	1
R:R:F87	R:R:T142	3.89	0	Yes	No	6	4	1	2
R:R:G88	R:R:S91	3.71	0	No	No	5	5	2	2
R:R:Y238	R:R:Y90	11.91	8	Yes	No	7	5	1	1
R:R:F138	R:R:S91	15.85	0	No	No	3	5	2	2
R:R:C141	R:R:S91	3.44	0	No	No	7	5	1	2
R:R:L183	R:R:Y94	10.55	0	No	Yes	5	8	1	2
R:R:Y238	R:R:Y94	2.98	8	Yes	Yes	7	8	1	2
R:R:H242	R:R:Y94	4.36	8	Yes	Yes	6	8	2	2
R:R:V144	R:R:V179	3.21	8	No	No	5	4	1	1
R:R:Q148	R:R:Y149	9.02	8	No	No	5	5	1	2
R:R:Q148	R:R:Y165	11.27	8	No	Yes	5	4	1	1
R:R:F168	R:R:Y165	6.19	0	No	Yes	4	4	2	1
R:R:F168	R:R:Q172	8.2	0	No	No	4	1	2	1
R:R:Q172	R:R:T169	8.5	0	No	No	1	4	1	2
R:R:R180	R:R:V176	7.85	8	Yes	No	5	4	1	1
R:R:H242	R:R:R180	19.18	8	Yes	Yes	6	5	2	1
R:R:R180	R:R:R255	15.99	8	Yes	Yes	5	5	1	1
R:R:E182	R:R:L183	3.98	0	No	No	4	5	2	1
R:R:H242	R:R:Y238	6.53	8	Yes	Yes	6	7	2	1
R:R:R255	R:R:Y238	8.23	8	Yes	Yes	5	7	1	1
R:R:A258	R:R:Y238	4	0	No	Yes	7	7	2	1
R:R:P252	R:R:R255	8.65	0	Yes	Yes	1	5	2	1
R:R:S86	R:R:Y90	2.54	0	No	No	6	5	2	1
L:L:?1	R:R:V147	1.07	8	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	16.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.67
Average Nodes In Shell	31.00
Average Hubs In Shell	9.00
Average Links In Shell	42.00
Average Links Mediated by Hubs In Shell	33.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	14.83
Average Number Of Links With An Hub	6.08
Average Interaction Strength	7.82
Average Nodes In Shell	33.17
Average Hubs In Shell	12.33
Average Links In Shell	47.08
Average Links Mediated by Hubs In Shell	41.67

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)