CodeA1L
Name[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
FormulaC24 H31 N9 O3
Molecular Weight493.561
SMILES
PubChem44129754
Formal Charge0
Total Atoms67
Total Chiral Atoms1
Total Bonds68
Total Aromatic Bonds12
Networks38
 missing image

This ligand is also present in the following 38 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IEB C Orphan Orphan GPR156 Homo Sapiens A1LYA - - 3.03 2024-02-14 doi.org/10.1038/s41594-024-01224-7

A 2D representation of the interactions of A1L in 8IEB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L124 10.95 2 Yes No 0 5 0 1
L:L:?1 R:R:L127 4.69 2 Yes No 0 9 0 1
L:L:?1 R:R:C128 4.48 2 Yes No 0 9 0 1
L:L:?1 R:R:T131 6.66 2 Yes No 0 8 0 1
L:L:?1 R:R:W183 10.3 2 Yes Yes 0 9 0 1
L:L:?1 R:R:F215 4.13 2 Yes No 0 5 0 1
L:L:?1 R:R:A217 4.45 2 Yes No 0 8 0 1
L:L:?1 R:R:S221 9.33 2 Yes No 0 8 0 1
L:L:?1 R:R:I225 4.03 2 Yes No 0 7 0 1
L:L:?1 R:R:W229 8.37 2 Yes Yes 0 5 0 1
L:L:?1 R:R:K232 9.56 2 Yes Yes 0 9 0 1
L:L:?1 R:R:L267 7.04 2 Yes No 0 7 0 1
L:L:?1 R:R:L274 3.91 2 Yes No 0 6 0 1
L:L:?1 R:R:F275 6.88 2 Yes No 0 4 0 1
L:L:?1 R:R:T278 9.16 2 Yes No 0 8 0 1
L:L:?1 R:R:R279 8.24 2 Yes Yes 0 6 0 1
L:L:?1 R:R:C299 3.59 2 Yes No 0 9 0 1
R:R:L127 R:R:S101 7.51 0 No No 9 9 1 2
R:R:Q121 R:R:W183 3.29 2 No Yes 9 9 2 1
R:R:Q121 R:R:V184 10.03 2 No Yes 9 7 2 2
R:R:I189 R:R:Q121 6.86 2 No No 6 9 2 2
R:R:L124 R:R:W183 3.42 2 No Yes 5 9 1 1
R:R:I296 R:R:L127 7.14 0 No No 9 9 2 1
R:R:C128 R:R:L180 3.17 0 No No 9 9 1 2
R:R:F135 R:R:L236 4.87 2 No Yes 8 9 2 2
R:R:F135 R:R:L267 3.65 2 No No 8 7 2 1
R:R:D176 R:R:K232 8.3 0 No Yes 9 9 2 1
R:R:V184 R:R:W183 3.68 2 Yes Yes 7 9 2 1
R:R:I189 R:R:W183 4.7 2 No Yes 6 9 2 1
R:R:S218 R:R:W183 6.18 0 No Yes 9 9 2 1
R:R:W183 R:R:W224 18.74 2 Yes Yes 9 9 1 2
R:R:F215 R:R:T213 5.19 0 No No 5 5 1 2
R:R:D222 R:R:I225 4.2 0 Yes No 5 7 2 1
R:R:D222 R:R:R279 9.53 0 Yes Yes 5 6 2 1
R:R:F275 R:R:I225 8.79 2 No No 4 7 1 1
R:R:A271 R:R:W229 3.89 0 No Yes 7 5 2 1
R:R:F275 R:R:W229 11.02 2 No Yes 4 5 1 1
R:R:C231 R:R:K232 6.47 0 No Yes 6 9 2 1
R:R:L236 R:R:L267 6.92 2 Yes No 9 7 2 1
R:R:L274 R:R:T292 4.42 0 No No 6 8 1 2
R:R:R279 R:R:Y280 6.17 2 Yes No 6 7 1 2
R:R:R279 S:S:D222 13.1 2 Yes No 6 5 1 2
R:R:Y280 S:S:D222 5.75 2 No No 7 5 2 2
R:R:I228 R:R:K232 2.91 0 No Yes 6 9 2 1
R:R:G272 R:R:W229 2.81 0 No Yes 7 5 2 1
R:R:A270 R:R:C299 1.81 0 No No 5 9 2 1
R:R:G295 R:R:L274 1.71 0 No No 8 6 2 1
R:R:T278 R:R:V277 1.59 0 No Yes 8 8 1 2
R:R:T278 R:R:V288 1.59 0 No No 8 8 1 2
R:R:T292 R:R:V288 1.59 0 No No 8 8 2 2
R:R:G230 R:R:W229 1.41 0 No Yes 6 5 2 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.81
Average Nodes In Shell43.00
Average Hubs In Shell10.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of A1L in 8IEB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:L124 10.95 1 Yes No 0 5 0 1
M:M:?1 S:S:L127 3.91 1 Yes No 0 9 0 1
M:M:?1 S:S:T131 6.66 1 Yes No 0 8 0 1
M:M:?1 S:S:W183 7.72 1 Yes Yes 0 9 0 1
M:M:?1 S:S:I189 4.03 1 Yes Yes 0 6 0 1
M:M:?1 S:S:F215 5.5 1 Yes Yes 0 5 0 1
M:M:?1 S:S:A217 6.23 1 Yes No 0 8 0 1
M:M:?1 S:S:S221 6.79 1 Yes No 0 8 0 1
M:M:?1 S:S:I225 5.64 1 Yes No 0 7 0 1
M:M:?1 S:S:I228 4.03 1 Yes No 0 6 0 1
M:M:?1 S:S:W229 17.37 1 Yes No 0 5 0 1
M:M:?1 S:S:K232 5.58 1 Yes No 0 9 0 1
M:M:?1 S:S:L267 6.26 1 Yes No 0 7 0 1
M:M:?1 S:S:A271 3.56 1 Yes No 0 7 0 1
M:M:?1 S:S:L274 4.69 1 Yes No 0 6 0 1
M:M:?1 S:S:T278 8.33 1 Yes No 0 8 0 1
M:M:?1 S:S:R279 9.61 1 Yes Yes 0 6 0 1
M:M:?1 S:S:H282 4.36 1 Yes No 0 5 0 1
M:M:?1 S:S:C299 3.59 1 Yes No 0 9 0 1
R:R:D222 S:S:R279 14.29 0 Yes Yes 5 6 2 1
S:S:L127 S:S:S101 9.01 0 No No 9 9 1 2
S:S:F105 S:S:L127 3.65 0 No No 9 9 2 1
S:S:F105 S:S:T292 7.78 0 No No 9 8 2 2
S:S:Q121 S:S:W183 9.86 1 No Yes 9 9 2 1
S:S:Q121 S:S:V184 4.3 1 No No 9 7 2 2
S:S:I189 S:S:Q121 8.23 1 Yes No 6 9 1 2
S:S:L124 S:S:W183 4.56 1 No Yes 5 9 1 1
S:S:C128 S:S:K232 3.23 19 No No 9 9 2 1
S:S:K232 S:S:S132 4.59 0 No No 9 9 1 2
S:S:F135 S:S:L267 3.65 0 No No 8 7 2 1
S:S:V184 S:S:W183 3.68 1 No Yes 7 9 2 1
S:S:I189 S:S:W183 7.05 1 Yes Yes 6 9 1 1
S:S:W183 S:S:W224 14.06 1 Yes Yes 9 9 1 2
S:S:I194 S:S:L192 5.71 1 No Yes 8 7 2 2
S:S:F215 S:S:L192 4.87 1 Yes Yes 5 7 1 2
S:S:F215 S:S:I194 3.77 1 Yes No 5 8 1 2
S:S:F215 S:S:T213 3.89 1 Yes No 5 5 1 2
S:S:S218 S:S:S221 3.26 1 No No 9 8 2 1
S:S:S218 S:S:W224 3.71 1 No Yes 9 9 2 2
S:S:D222 S:S:R279 8.34 2 No Yes 5 6 2 1
S:S:I225 S:S:W229 9.4 1 No No 7 5 1 1
S:S:F275 S:S:I225 3.77 0 No No 4 7 2 1
S:S:A271 S:S:W229 3.89 1 No No 7 5 1 1
S:S:L274 S:S:T292 5.9 0 No No 6 8 1 2
S:S:F275 S:S:R279 9.62 0 No Yes 4 6 2 1
S:S:T278 S:S:V288 4.76 0 No No 8 8 1 2
S:S:A271 S:S:G272 1.95 1 No No 7 7 1 2
S:S:A270 S:S:C299 1.81 0 No No 5 9 2 1
S:S:C216 S:S:I189 1.64 1 Yes Yes 9 6 2 1
S:S:C299 S:S:L266 1.59 0 No No 9 8 1 2
StatisticsValue
Average Number Of Links19.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.57
Average Nodes In Shell41.00
Average Hubs In Shell9.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IED C Orphan Orphan GPR156 Homo Sapiens A1LYA - Go/Beta1/Gamma2 3.33 2024-02-14 doi.org/10.1038/s41594-024-01224-7

A 2D representation of the interactions of A1L in 8IED
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L124 10.95 1 Yes No 0 5 0 1
L:L:?1 R:R:L127 3.91 1 Yes Yes 0 9 0 1
L:L:?1 R:R:C128 2.69 1 Yes Yes 0 9 0 1
L:L:?1 R:R:T131 6.66 1 Yes No 0 8 0 1
L:L:?1 R:R:W183 7.72 1 Yes Yes 0 9 0 1
L:L:?1 R:R:I189 4.03 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F215 5.5 1 Yes Yes 0 5 0 1
L:L:?1 R:R:A217 6.23 1 Yes No 0 8 0 1
L:L:?1 R:R:S221 6.79 1 Yes No 0 8 0 1
L:L:?1 R:R:I225 5.64 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I228 4.03 1 Yes No 0 6 0 1
L:L:?1 R:R:W229 17.37 1 Yes No 0 5 0 1
L:L:?1 R:R:K232 5.58 1 Yes Yes 0 9 0 1
L:L:?1 R:R:L236 2.35 1 Yes Yes 0 9 0 1
L:L:?1 R:R:L267 6.26 1 Yes No 0 7 0 1
L:L:?1 R:R:A271 3.56 1 Yes No 0 7 0 1
L:L:?1 R:R:L274 4.69 1 Yes No 0 6 0 1
L:L:?1 R:R:T278 8.33 1 Yes No 0 8 0 1
L:L:?1 R:R:R279 9.61 1 Yes Yes 0 6 0 1
L:L:?1 R:R:H282 4.36 1 Yes No 0 5 0 1
L:L:?1 R:R:C299 3.59 1 Yes No 0 9 0 1
R:R:L127 R:R:S101 9.01 1 Yes Yes 9 9 1 2
R:R:I296 R:R:S101 3.1 1 Yes Yes 9 9 2 2
R:R:F105 R:R:L127 3.65 1 Yes Yes 9 9 2 1
R:R:F105 R:R:T292 7.78 1 Yes No 9 8 2 2
R:R:F105 R:R:I296 2.51 1 Yes Yes 9 9 2 2
R:R:I120 R:R:L124 2.85 1 Yes No 6 5 2 1
R:R:I120 R:R:I189 2.94 1 Yes Yes 6 6 2 1
R:R:Q121 R:R:W183 9.86 1 No Yes 9 9 2 1
R:R:Q121 R:R:V184 4.3 1 No No 9 7 2 2
R:R:I189 R:R:Q121 8.23 1 Yes No 6 9 1 2
R:R:L124 R:R:W183 4.56 1 No Yes 5 9 1 1
R:R:I296 R:R:L127 2.85 1 Yes Yes 9 9 2 1
R:R:C128 R:R:D176 9.34 1 Yes Yes 9 9 1 2
R:R:C128 R:R:L180 3.17 1 Yes Yes 9 9 1 2
R:R:C128 R:R:K232 3.23 1 Yes Yes 9 9 1 1
R:R:K232 R:R:T131 3 1 Yes No 9 8 1 1
R:R:L267 R:R:T131 2.95 1 No No 7 8 1 1
R:R:D176 R:R:S132 5.89 1 Yes No 9 9 2 2
R:R:K232 R:R:S132 4.59 1 Yes No 9 9 1 2
R:R:F135 R:R:L267 3.65 0 No No 8 7 2 1
R:R:D176 R:R:L180 6.79 1 Yes Yes 9 9 2 2
R:R:L180 R:R:W183 2.28 1 Yes Yes 9 9 2 1
R:R:V184 R:R:W183 3.68 1 No Yes 7 9 2 1
R:R:I189 R:R:W183 7.05 1 Yes Yes 6 9 1 1
R:R:W183 R:R:W224 14.06 1 Yes Yes 9 9 1 2
R:R:I194 R:R:L192 5.71 1 No Yes 8 7 2 2
R:R:F215 R:R:L192 4.87 1 Yes Yes 5 7 1 2
R:R:F215 R:R:I194 3.77 1 Yes No 5 8 1 2
R:R:F215 R:R:T213 3.89 1 Yes No 5 5 1 2
R:R:S218 R:R:S221 3.26 1 No No 9 8 2 1
R:R:S218 R:R:W224 3.71 1 No Yes 9 9 2 2
R:R:D222 R:R:S221 2.94 1 Yes No 5 8 2 1
R:R:D222 R:R:I225 2.8 1 Yes Yes 5 7 2 1
R:R:D222 R:R:F275 2.39 1 Yes Yes 5 4 2 2
R:R:D222 R:R:R279 8.34 1 Yes Yes 5 6 2 1
R:R:I225 R:R:W229 9.4 1 Yes No 7 5 1 1
R:R:F275 R:R:I225 3.77 1 Yes Yes 4 7 2 1
R:R:A271 R:R:W229 3.89 1 No No 7 5 1 1
R:R:G233 R:R:L236 5.13 0 No Yes 8 9 2 1
R:R:L236 R:R:V264 5.96 1 Yes No 9 8 1 2
R:R:L236 R:R:V268 2.98 1 Yes No 9 7 1 2
R:R:L236 S:S:L237 4.15 1 Yes No 9 7 1 2
R:R:V264 S:S:L237 10.43 1 No No 8 7 2 2
R:R:A271 R:R:G272 1.95 1 No No 7 7 1 2
R:R:L274 R:R:T292 5.9 0 No No 6 8 1 2
R:R:F275 R:R:R279 9.62 1 Yes Yes 4 6 2 1
R:R:F275 S:S:D222 2.39 1 Yes Yes 4 5 2 2
R:R:T278 R:R:V288 4.76 0 No No 8 8 1 2
R:R:R279 S:S:D222 14.29 1 Yes Yes 6 5 1 2
R:R:A270 R:R:C299 1.81 0 No No 5 9 2 1
R:R:C216 R:R:I120 1.64 1 Yes Yes 9 6 2 2
R:R:C216 R:R:I189 1.64 1 Yes Yes 9 6 2 1
R:R:C299 R:R:L266 1.59 0 No No 9 8 1 2
StatisticsValue
Average Number Of Links21.00
Average Number Of Links With An Hub9.00
Average Interaction Strength6.18
Average Nodes In Shell50.00
Average Hubs In Shell22.00
Average Links In Shell74.00
Average Links Mediated by Hubs In Shell63.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of A1L in 8IED
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:L124 10.95 1 Yes No 0 5 0 1
M:M:?1 S:S:L127 4.69 1 Yes Yes 0 9 0 1
M:M:?1 S:S:C128 4.48 1 Yes No 0 9 0 1
M:M:?1 S:S:T131 6.66 1 Yes No 0 8 0 1
M:M:?1 S:S:W183 10.3 1 Yes Yes 0 9 0 1
M:M:?1 S:S:I189 2.42 1 Yes Yes 0 6 0 1
M:M:?1 S:S:F215 4.13 1 Yes No 0 5 0 1
M:M:?1 S:S:A217 4.45 1 Yes No 0 8 0 1
M:M:?1 S:S:S218 2.54 1 Yes Yes 0 9 0 1
M:M:?1 S:S:S221 9.33 1 Yes No 0 8 0 1
M:M:?1 S:S:W224 1.93 1 Yes Yes 0 9 0 1
M:M:?1 S:S:I225 4.03 1 Yes No 0 7 0 1
M:M:?1 S:S:W229 8.37 1 Yes Yes 0 5 0 1
M:M:?1 S:S:K232 9.56 1 Yes Yes 0 9 0 1
M:M:?1 S:S:L267 7.04 1 Yes No 0 7 0 1
M:M:?1 S:S:A271 2.67 1 Yes No 0 7 0 1
M:M:?1 S:S:L274 3.91 1 Yes No 0 6 0 1
M:M:?1 S:S:F275 6.88 1 Yes No 0 4 0 1
M:M:?1 S:S:T278 9.16 1 Yes No 0 8 0 1
M:M:?1 S:S:R279 8.24 1 Yes Yes 0 6 0 1
M:M:?1 S:S:C299 3.59 1 Yes No 0 9 0 1
R:R:D222 S:S:R279 13.1 1 Yes Yes 5 6 2 1
R:R:D222 S:S:Y280 5.75 1 Yes No 5 7 2 2
S:S:L127 S:S:T98 2.95 1 Yes No 9 9 1 2
S:S:L127 S:S:S101 7.51 1 Yes No 9 9 1 2
S:S:F105 S:S:L127 2.44 1 Yes Yes 9 9 2 1
S:S:F105 S:S:T292 7.78 1 Yes No 9 8 2 2
S:S:F105 S:S:I296 3.77 1 Yes No 9 9 2 2
S:S:E117 S:S:I189 2.73 0 No Yes 6 6 2 1
S:S:I120 S:S:L124 2.85 0 Yes No 6 5 2 1
S:S:I120 S:S:I189 2.94 0 Yes Yes 6 6 2 1
S:S:Q121 S:S:W183 3.29 1 No Yes 9 9 2 1
S:S:Q121 S:S:V184 10.03 1 No Yes 9 7 2 2
S:S:I189 S:S:Q121 6.86 1 Yes No 6 9 1 2
S:S:L124 S:S:W183 3.42 1 No Yes 5 9 1 1
S:S:I296 S:S:L127 7.14 1 No Yes 9 9 2 1
S:S:C128 S:S:L180 3.17 0 No Yes 9 9 1 2
S:S:F135 S:S:T131 2.59 1 Yes No 8 8 2 1
S:S:K232 S:S:T131 3 1 Yes No 9 8 1 1
S:S:F135 S:S:L236 4.87 1 Yes Yes 8 9 2 2
S:S:F135 S:S:L267 3.65 1 Yes No 8 7 2 1
S:S:D176 S:S:K232 8.3 1 No Yes 9 9 2 1
S:S:L180 S:S:W183 2.28 0 Yes Yes 9 9 2 1
S:S:T182 S:S:T186 3.14 1 No No 5 7 2 2
S:S:T182 S:S:W224 7.28 1 No Yes 5 9 2 1
S:S:V184 S:S:W183 3.68 1 Yes Yes 7 9 2 1
S:S:I189 S:S:W183 4.7 1 Yes Yes 6 9 1 1
S:S:S218 S:S:W183 6.18 1 Yes Yes 9 9 1 1
S:S:W183 S:S:W224 18.74 1 Yes Yes 9 9 1 1
S:S:D187 S:S:T186 4.34 1 Yes No 9 7 2 2
S:S:T186 S:S:W224 4.85 1 No Yes 7 9 2 1
S:S:D187 S:S:S218 2.94 1 Yes Yes 9 9 2 1
S:S:D187 S:S:W224 14.52 1 Yes Yes 9 9 2 1
S:S:I189 S:S:S218 3.1 1 Yes Yes 6 9 1 1
S:S:I194 S:S:T213 3.04 1 Yes No 8 5 2 2
S:S:F215 S:S:I194 2.51 1 No Yes 5 8 1 2
S:S:F215 S:S:T213 5.19 1 No No 5 5 1 2
S:S:S218 S:S:W224 2.47 1 Yes Yes 9 9 1 1
S:S:D222 S:S:S221 2.94 1 Yes No 5 8 2 1
S:S:D222 S:S:I225 4.2 1 Yes No 5 7 2 1
S:S:D222 S:S:R279 9.53 1 Yes Yes 5 6 2 1
S:S:F275 S:S:I225 8.79 1 No No 4 7 1 1
S:S:I228 S:S:K232 2.91 0 No Yes 6 9 2 1
S:S:A271 S:S:W229 3.89 1 No Yes 7 5 1 1
S:S:G272 S:S:W229 2.81 1 No Yes 7 5 2 1
S:S:F275 S:S:W229 11.02 1 No Yes 4 5 1 1
S:S:C231 S:S:K232 6.47 0 No Yes 6 9 2 1
S:S:L236 S:S:L267 6.92 1 Yes No 9 7 2 1
S:S:A271 S:S:G272 1.95 1 No No 7 7 1 2
S:S:L274 S:S:T292 4.42 0 No No 6 8 1 2
S:S:R279 S:S:Y280 6.17 1 Yes No 6 7 1 2
S:S:A270 S:S:C299 1.81 0 No No 5 9 2 1
S:S:G295 S:S:L274 1.71 0 No No 8 6 2 1
S:S:T278 S:S:V277 1.59 0 No Yes 8 8 1 2
S:S:T278 S:S:V288 1.59 0 No No 8 8 1 2
S:S:T292 S:S:V288 1.59 0 No No 8 8 2 2
S:S:G230 S:S:W229 1.41 0 No Yes 6 5 2 1
StatisticsValue
Average Number Of Links21.00
Average Number Of Links With An Hub8.00
Average Interaction Strength5.97
Average Nodes In Shell51.00
Average Hubs In Shell20.00
Average Links In Shell77.00
Average Links Mediated by Hubs In Shell68.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IEI C Orphan Orphan GPR156 Homo Sapiens A1LYA - - 2.62 2024-02-14 doi.org/10.1038/s41594-024-01224-7

A 2D representation of the interactions of A1L in 8IEI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L124 10.17 1 Yes No 0 5 0 1
L:L:?1 R:R:L127 8.6 1 Yes No 0 9 0 1
L:L:?1 R:R:T131 5.83 1 Yes No 0 8 0 1
L:L:?1 R:R:W183 5.15 1 Yes Yes 0 9 0 1
L:L:?1 R:R:I189 4.03 1 Yes No 0 6 0 1
L:L:?1 R:R:F215 4.13 1 Yes No 0 5 0 1
L:L:?1 R:R:S221 5.94 1 Yes No 0 8 0 1
L:L:?1 R:R:I225 4.03 1 Yes No 0 7 0 1
L:L:?1 R:R:I228 4.84 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W229 9.65 1 Yes No 0 5 0 1
L:L:?1 R:R:K232 9.56 1 Yes Yes 0 9 0 1
L:L:?1 R:R:L267 7.82 1 Yes No 0 7 0 1
L:L:?1 R:R:L274 4.69 1 Yes No 0 6 0 1
L:L:?1 R:R:T278 4.16 1 Yes No 0 8 0 1
L:L:?1 R:R:R279 12.35 1 Yes Yes 0 6 0 1
L:L:?1 R:R:C299 4.48 1 Yes No 0 9 0 1
R:R:L127 R:R:S101 7.51 0 No No 9 9 1 2
R:R:I120 R:R:I189 5.89 0 Yes No 6 6 2 1
R:R:Q121 R:R:W183 3.29 1 No Yes 9 9 2 1
R:R:Q121 R:R:V184 7.16 1 No No 9 7 2 2
R:R:I189 R:R:Q121 6.86 0 No No 6 9 1 2
R:R:L124 R:R:W183 3.42 1 No Yes 5 9 1 1
R:R:I296 R:R:L127 4.28 0 No No 9 9 2 1
R:R:C128 R:R:I228 3.27 0 No Yes 9 6 2 1
R:R:C128 R:R:K232 3.23 0 No Yes 9 9 2 1
R:R:D176 R:R:S132 8.83 1 No No 9 9 2 2
R:R:K232 R:R:S132 4.59 1 Yes No 9 9 1 2
R:R:F135 R:R:L236 3.65 1 No Yes 8 9 2 2
R:R:F135 R:R:L267 6.09 1 No No 8 7 2 1
R:R:D176 R:R:K232 9.68 1 No Yes 9 9 2 1
R:R:I228 R:R:L179 4.28 1 Yes No 6 7 1 2
R:R:V184 R:R:W183 3.68 1 No Yes 7 9 2 1
R:R:S218 R:R:W183 4.94 0 No Yes 9 9 2 1
R:R:W183 R:R:W224 17.81 1 Yes Yes 9 9 1 2
R:R:F215 R:R:T213 5.19 0 No No 5 5 1 2
R:R:D222 R:R:R279 10.72 1 Yes Yes 5 6 2 1
R:R:I225 R:R:W229 9.4 1 No No 7 5 1 1
R:R:F275 R:R:I225 3.77 0 No No 4 7 2 1
R:R:I228 R:R:W229 4.7 1 Yes No 6 5 1 1
R:R:L236 R:R:L267 4.15 1 Yes No 9 7 2 1
R:R:L274 R:R:T292 7.37 0 No No 6 8 1 2
R:R:F275 R:R:R279 6.41 0 No Yes 4 6 2 1
R:R:R279 R:R:Y280 6.17 1 Yes Yes 6 7 1 2
R:R:R279 S:S:D222 10.72 1 Yes No 6 5 1 2
R:R:Y280 S:S:D222 6.9 1 Yes No 7 5 2 2
R:R:A217 R:R:F215 2.77 0 No No 8 5 2 1
L:L:?1 R:R:A271 2.67 1 Yes No 0 7 0 1
R:R:A271 R:R:G272 1.95 0 No No 7 7 1 2
R:R:T278 R:R:V288 1.59 0 No No 8 8 1 2
R:R:T292 R:R:V288 1.59 0 No No 8 8 2 2
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.36
Average Nodes In Shell40.00
Average Hubs In Shell10.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of A1L in 8IEI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:T98 3.33 1 Yes No 0 9 0 1
M:M:?1 S:S:L124 12.51 1 Yes No 0 5 0 1
M:M:?1 S:S:L127 5.47 1 Yes Yes 0 9 0 1
M:M:?1 S:S:T131 5.83 1 Yes No 0 8 0 1
M:M:?1 S:S:W183 5.79 1 Yes Yes 0 9 0 1
M:M:?1 S:S:I189 4.03 1 Yes Yes 0 6 0 1
M:M:?1 S:S:A217 3.56 1 Yes No 0 8 0 1
M:M:?1 S:S:S221 5.09 1 Yes No 0 8 0 1
M:M:?1 S:S:I228 4.03 1 Yes No 0 6 0 1
M:M:?1 S:S:W229 9.01 1 Yes No 0 5 0 1
M:M:?1 S:S:K232 7.97 1 Yes Yes 0 9 0 1
M:M:?1 S:S:L267 7.82 1 Yes No 0 7 0 1
M:M:?1 S:S:L274 4.69 1 Yes No 0 6 0 1
M:M:?1 S:S:T278 5 1 Yes No 0 8 0 1
M:M:?1 S:S:R279 8.24 1 Yes Yes 0 6 0 1
R:R:D222 S:S:F275 3.58 1 Yes No 5 4 2 2
R:R:D222 S:S:R279 16.68 1 Yes Yes 5 6 2 1
R:R:D222 S:S:Y280 6.9 1 Yes No 5 7 2 2
S:S:T300 S:S:T98 7.85 0 No No 9 9 2 1
S:S:L127 S:S:S101 7.51 0 Yes No 9 9 1 2
S:S:F105 S:S:L127 3.65 0 No Yes 9 9 2 1
S:S:F105 S:S:T292 7.78 0 No No 9 8 2 2
S:S:I120 S:S:I189 4.42 0 No Yes 6 6 2 1
S:S:Q121 S:S:W183 3.29 1 No Yes 9 9 2 1
S:S:Q121 S:S:V184 5.73 1 No No 9 7 2 2
S:S:I189 S:S:Q121 4.12 1 Yes No 6 9 1 2
S:S:L124 S:S:W183 3.42 1 No Yes 5 9 1 1
S:S:I296 S:S:L127 4.28 0 No Yes 9 9 2 1
S:S:C128 S:S:D176 4.67 1 No Yes 9 9 2 2
S:S:C128 S:S:K232 4.85 1 No Yes 9 9 2 1
S:S:K232 S:S:T131 4.5 1 Yes No 9 8 1 1
S:S:F135 S:S:L267 3.65 0 No No 8 7 2 1
S:S:D176 S:S:K232 6.91 1 Yes Yes 9 9 2 1
S:S:V184 S:S:W183 3.68 1 No Yes 7 9 2 1
S:S:I189 S:S:W183 4.7 1 Yes Yes 6 9 1 1
S:S:S218 S:S:W183 4.94 1 No Yes 9 9 2 1
S:S:W183 S:S:W224 14.06 1 Yes Yes 9 9 1 2
S:S:S218 S:S:W224 3.71 1 No Yes 9 9 2 2
S:S:I225 S:S:S221 3.1 0 No No 7 8 2 1
S:S:D222 S:S:R279 11.91 1 No Yes 5 6 2 1
S:S:I225 S:S:W229 10.57 0 No No 7 5 2 1
S:S:L274 S:S:T292 4.42 0 No No 6 8 1 2
S:S:F275 S:S:R279 9.62 1 No Yes 4 6 2 1
S:S:R279 S:S:Y280 4.12 1 Yes No 6 7 1 2
S:S:A217 S:S:F215 2.77 0 No No 8 5 1 2
M:M:?1 S:S:A271 2.67 1 Yes No 0 7 0 1
S:S:A271 S:S:G272 1.95 0 No No 7 7 1 2
S:S:A270 S:S:C299 1.81 0 No No 5 9 2 1
M:M:?1 S:S:C299 1.79 1 Yes No 0 9 0 1
S:S:G233 S:S:K232 1.74 0 No Yes 8 9 2 1
S:S:T278 S:S:V277 1.59 0 No No 8 8 1 2
S:S:T278 S:S:V288 1.59 0 No No 8 8 1 2
S:S:T292 S:S:V288 1.59 0 No No 8 8 2 2
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.70
Average Nodes In Shell42.00
Average Hubs In Shell9.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IEP C Orphan Orphan GPR156 Homo Sapiens A1LYA - - 2.61 2024-02-14 doi.org/10.1038/s41594-024-01224-7

A 2D representation of the interactions of A1L in 8IEP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L124 11.73 1 Yes No 0 5 0 1
L:L:?1 R:R:L127 7.82 1 Yes No 0 9 0 1
L:L:?1 R:R:T131 6.66 1 Yes No 0 8 0 1
L:L:?1 R:R:W183 5.15 1 Yes Yes 0 9 0 1
L:L:?1 R:R:I189 4.03 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F215 3.44 1 Yes No 0 5 0 1
L:L:?1 R:R:A217 4.45 1 Yes No 0 8 0 1
L:L:?1 R:R:S221 6.79 1 Yes No 0 8 0 1
L:L:?1 R:R:I225 3.23 1 Yes No 0 7 0 1
L:L:?1 R:R:I228 4.03 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W229 7.72 1 Yes Yes 0 5 0 1
L:L:?1 R:R:K232 10.36 1 Yes Yes 0 9 0 1
L:L:?1 R:R:L267 7.04 1 Yes No 0 7 0 1
L:L:?1 R:R:L274 4.69 1 Yes No 0 6 0 1
L:L:?1 R:R:T278 5 1 Yes No 0 8 0 1
L:L:?1 R:R:R279 9.61 1 Yes Yes 0 6 0 1
L:L:?1 R:R:C299 4.48 1 Yes No 0 9 0 1
R:R:L127 R:R:S101 7.51 0 No No 9 9 1 2
R:R:I120 R:R:I189 5.89 9 Yes Yes 6 6 2 1
R:R:Q121 R:R:W183 4.38 1 No Yes 9 9 2 1
R:R:Q121 R:R:V184 10.03 1 No No 9 7 2 2
R:R:I189 R:R:Q121 8.23 0 Yes No 6 9 1 2
R:R:L124 R:R:W183 3.42 1 No Yes 5 9 1 1
R:R:I296 R:R:L127 4.28 0 No No 9 9 2 1
R:R:C128 R:R:D176 4.67 1 Yes No 9 9 2 2
R:R:C128 R:R:I228 3.27 1 Yes Yes 9 6 2 1
R:R:C128 R:R:K232 3.23 1 Yes Yes 9 9 2 1
R:R:K232 R:R:T131 3 1 Yes No 9 8 1 1
R:R:F135 R:R:L267 3.65 0 No No 8 7 2 1
R:R:D176 R:R:K232 9.68 1 No Yes 9 9 2 1
R:R:I228 R:R:L179 4.28 1 Yes No 6 7 1 2
R:R:V184 R:R:W183 3.68 1 No Yes 7 9 2 1
R:R:S218 R:R:W183 4.94 0 No Yes 9 9 2 1
R:R:W183 R:R:W224 14.99 1 Yes Yes 9 9 1 2
R:R:I189 R:R:S218 3.1 0 Yes No 6 9 1 2
R:R:D222 R:R:S221 4.42 1 Yes No 5 8 2 1
R:R:D222 R:R:R279 11.91 1 Yes Yes 5 6 2 1
R:R:I225 R:R:W229 10.57 1 No Yes 7 5 1 1
R:R:F275 R:R:I225 3.77 0 No No 4 7 2 1
R:R:I228 R:R:W229 3.52 1 Yes Yes 6 5 1 1
R:R:L236 R:R:L267 6.92 0 Yes No 9 7 2 1
R:R:L274 R:R:T292 5.9 0 No No 6 8 1 2
R:R:F275 R:R:R279 10.69 0 No Yes 4 6 2 1
R:R:R279 R:R:Y280 8.23 1 Yes Yes 6 7 1 2
R:R:R279 S:S:D222 10.72 1 Yes No 6 5 1 2
R:R:Y280 S:S:D222 6.9 1 Yes No 7 5 2 2
R:R:F215 R:R:T213 2.59 0 No No 5 5 1 2
R:R:A271 R:R:W229 2.59 0 No Yes 7 5 2 1
R:R:T278 R:R:V288 1.59 0 No No 8 8 1 2
R:R:T292 R:R:V288 1.59 0 No No 8 8 2 2
L:L:?1 R:R:A270 0.89 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links18.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.95
Average Nodes In Shell39.00
Average Hubs In Shell13.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of A1L in 8IEP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:T98 3.33 1 Yes No 0 9 0 1
M:M:?1 S:S:L124 12.51 1 Yes No 0 5 0 1
M:M:?1 S:S:L127 4.69 1 Yes Yes 0 9 0 1
M:M:?1 S:S:T131 8.33 1 Yes No 0 8 0 1
M:M:?1 S:S:W183 7.72 1 Yes Yes 0 9 0 1
M:M:?1 S:S:S221 5.09 1 Yes No 0 8 0 1
M:M:?1 S:S:I225 3.23 1 Yes No 0 7 0 1
M:M:?1 S:S:I228 3.23 1 Yes No 0 6 0 1
M:M:?1 S:S:W229 9.65 1 Yes No 0 5 0 1
M:M:?1 S:S:K232 8.76 1 Yes Yes 0 9 0 1
M:M:?1 S:S:L267 7.04 1 Yes No 0 7 0 1
M:M:?1 S:S:L274 4.69 1 Yes No 0 6 0 1
M:M:?1 S:S:T278 5 1 Yes No 0 8 0 1
M:M:?1 S:S:R279 6.86 1 Yes Yes 0 6 0 1
R:R:D222 S:S:R279 11.91 1 Yes Yes 5 6 2 1
R:R:D222 S:S:Y280 8.05 1 Yes No 5 7 2 2
S:S:T300 S:S:T98 4.71 0 No No 9 9 2 1
S:S:L127 S:S:S101 9.01 0 Yes No 9 9 1 2
S:S:F105 S:S:L127 6.09 0 No Yes 9 9 2 1
S:S:F105 S:S:T292 7.78 0 No No 9 8 2 2
S:S:Q121 S:S:W183 4.38 0 No Yes 9 9 2 1
S:S:L124 S:S:W183 3.42 1 No Yes 5 9 1 1
S:S:I296 S:S:L127 4.28 0 No Yes 9 9 2 1
S:S:C128 S:S:D176 4.67 1 No No 9 9 2 2
S:S:C128 S:S:K232 3.23 1 No Yes 9 9 2 1
S:S:K232 S:S:T131 4.5 1 Yes No 9 8 1 1
S:S:D176 S:S:S132 8.83 1 No Yes 9 9 2 2
S:S:K232 S:S:S132 4.59 1 Yes Yes 9 9 1 2
S:S:F135 S:S:L236 4.87 1 Yes No 8 9 2 2
S:S:F135 S:S:L267 3.65 1 Yes No 8 7 2 1
S:S:D176 S:S:K232 8.3 1 No Yes 9 9 2 1
S:S:I189 S:S:W183 3.52 0 No Yes 6 9 2 1
S:S:S218 S:S:W183 3.71 0 No Yes 9 9 2 1
S:S:W183 S:S:W224 14.99 1 Yes Yes 9 9 1 2
S:S:I194 S:S:T213 3.04 1 Yes No 8 5 2 2
S:S:F215 S:S:I194 5.02 1 No Yes 5 8 1 2
S:S:F215 S:S:T213 7.78 1 No No 5 5 1 2
S:S:D222 S:S:R279 10.72 1 No Yes 5 6 2 1
S:S:I225 S:S:W229 10.57 1 No No 7 5 1 1
S:S:L236 S:S:L267 5.54 1 No No 9 7 2 1
S:S:L274 S:S:T292 5.9 0 No No 6 8 1 2
S:S:F275 S:S:R279 7.48 0 No Yes 4 6 2 1
S:S:R279 S:S:Y280 6.17 1 Yes No 6 7 1 2
M:M:?1 S:S:F215 2.75 1 Yes No 0 5 0 1
M:M:?1 S:S:C299 2.69 1 Yes No 0 9 0 1
M:M:?1 S:S:A217 2.67 1 Yes No 0 8 0 1
S:S:A271 S:S:W229 2.59 0 No No 7 5 2 1
S:S:A270 S:S:C299 1.81 0 No No 5 9 2 1
S:S:G233 S:S:K232 1.74 0 No Yes 8 9 2 1
S:S:T278 S:S:V277 1.59 0 No Yes 8 8 1 2
S:S:I228 S:S:L179 1.43 0 No No 6 7 1 2
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.78
Average Nodes In Shell43.00
Average Hubs In Shell11.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8X9U B2 Adhesion Adhesion ADGRD1 Homo Sapiens Metenolone - chim(NtGi1-Gs)/Beta1/Gamma2 2.88 2025-02-12 doi.org/10.1016/j.cell.2025.01.006

A 2D representation of the interactions of A1L in 8X9U
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L619 5.47 6 Yes No 0 9 0 1
L:L:?1 R:R:H640 3.63 6 Yes Yes 0 9 0 1
L:L:?1 R:R:W705 13.51 6 Yes Yes 0 9 0 1
L:L:?1 R:R:L706 8.6 6 Yes No 0 9 0 1
L:L:?1 R:R:I713 5.64 6 Yes No 0 8 0 1
L:L:?1 R:R:F716 10.32 6 Yes Yes 0 9 0 1
L:L:?1 R:R:F791 4.82 6 Yes No 0 9 0 1
R:R:F623 R:R:L619 10.96 6 Yes No 6 9 2 1
R:R:L619 R:R:W705 3.42 6 No Yes 9 9 1 1
R:R:S622 R:R:W705 4.94 0 No Yes 8 9 2 1
R:R:F623 R:R:W705 4.01 6 Yes Yes 6 9 2 1
R:R:H640 R:R:L644 9 6 Yes Yes 9 9 1 2
R:R:C687 R:R:H640 5.9 0 No Yes 8 9 2 1
R:R:H640 R:R:Y698 5.44 6 Yes Yes 9 9 1 2
R:R:H640 R:R:L706 10.29 6 Yes No 9 9 1 1
R:R:F716 R:R:H640 5.66 6 Yes Yes 9 9 1 1
R:R:F716 R:R:L644 4.87 6 Yes Yes 9 9 1 2
R:R:F647 R:R:F716 5.36 0 Yes Yes 9 9 2 1
R:R:L706 R:R:Y698 9.38 6 No Yes 9 9 1 2
R:R:N703 R:R:W705 12.43 0 No Yes 7 9 2 1
R:R:F791 R:R:N795 9.67 0 No No 9 9 1 2
R:R:F791 R:R:G776 3.01 0 No No 9 9 1 2
R:R:A715 R:R:H640 2.93 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.43
Average Nodes In Shell18.00
Average Hubs In Shell8.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XOF A Orphan Orphan GPR30 Homo Sapiens Lys05 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.6 2024-04-10 doi.org/10.1038/s41422-024-00963-y

A 2D representation of the interactions of A1L in 8XOF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L137 6.26 0 Yes No 0 6 0 1
L:L:?1 R:R:E275 8.98 0 Yes No 0 6 0 1
L:L:?1 R:R:H282 3.63 0 Yes No 0 4 0 1
L:L:?1 R:R:H300 5.81 0 Yes No 0 4 0 1
R:R:D111 R:R:L137 13.57 0 No No 7 6 2 1
R:R:F278 R:R:H282 7.92 0 No No 5 4 2 1
R:R:H282 R:R:H302 4.78 0 No No 4 4 1 2
R:R:E275 R:R:W272 3.27 0 No Yes 6 9 1 2
R:R:E275 R:R:V309 2.85 0 No Yes 6 7 1 2
R:R:L137 R:R:M133 2.83 0 No No 6 5 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.17
Average Nodes In Shell11.00
Average Hubs In Shell3.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XYI A Protein Chemokine CXCR3 Homo Sapiens VUF10661 - - 3.16 2025-02-26 To be published

A 2D representation of the interactions of A1L in 8XYI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D52 R:R:F51 4.78 1 Yes Yes 5 5 1 2
R:R:F51 R:R:F55 10.72 0 Yes No 5 4 2 2
R:R:D52 R:R:L56 4.07 1 Yes Yes 5 5 1 1
R:R:D52 R:R:S301 5.89 1 Yes No 5 4 1 2
L:L:?1 R:R:D52 3.07 1 Yes Yes 0 5 0 1
R:R:F55 R:R:L56 4.87 0 No Yes 4 5 2 1
R:R:F55 R:R:L59 4.87 0 No No 4 6 2 2
R:R:L56 R:R:Y60 8.21 1 Yes Yes 5 8 1 1
R:R:A113 R:R:L56 4.73 1 No Yes 5 5 1 1
L:L:?1 R:R:L56 3.91 1 Yes Yes 0 5 0 1
R:R:L59 R:R:Y60 5.86 0 No Yes 6 8 2 1
R:R:A110 R:R:Y60 4 0 No Yes 7 8 2 1
L:L:?1 R:R:Y60 5.3 1 Yes Yes 0 8 0 1
R:R:F131 R:R:L102 12.18 1 Yes No 5 6 1 2
R:R:T105 R:R:W109 4.85 1 No Yes 7 5 2 1
R:R:F131 R:R:T105 3.89 1 Yes No 5 7 1 2
R:R:D112 R:R:W109 3.35 1 No Yes 5 5 2 1
R:R:W109 R:R:W117 8.43 1 Yes Yes 5 9 1 2
R:R:A127 R:R:W109 3.89 0 No Yes 5 5 2 1
R:R:F131 R:R:W109 6.01 1 Yes Yes 5 5 1 1
R:R:C203 R:R:W109 5.22 1 Yes Yes 9 5 2 1
L:L:?1 R:R:W109 23.81 1 Yes Yes 0 5 0 1
R:R:D112 R:R:W117 10.05 1 No Yes 5 9 2 2
L:L:?1 R:R:A113 5.34 1 Yes No 0 5 0 1
R:R:C203 R:R:W117 3.92 1 Yes Yes 9 9 2 2
L:L:?1 R:R:G128 2.9 1 Yes No 0 6 0 1
R:R:F131 R:R:Y308 9.28 1 Yes No 5 6 1 1
L:L:?1 R:R:F131 10.32 1 Yes Yes 0 5 0 1
R:R:N132 R:R:Y136 5.81 1 No Yes 4 6 2 2
R:R:D186 R:R:N132 13.46 1 No No 4 4 2 2
R:R:N132 R:R:Y205 3.49 1 No Yes 4 3 2 1
R:R:F135 R:R:Y136 7.22 1 Yes Yes 7 6 1 2
R:R:F135 R:R:Q219 3.51 1 Yes No 7 5 1 1
R:R:F135 R:R:W268 6.01 1 Yes Yes 7 9 1 2
L:L:?1 R:R:F135 8.95 1 Yes Yes 0 7 0 1
R:R:Q219 R:R:Y136 6.76 1 No Yes 5 6 1 2
R:R:D186 R:R:Y205 9.2 1 No Yes 4 3 2 1
R:R:C203 R:R:L190 3.17 1 Yes Yes 9 5 2 2
R:R:L190 R:R:Y205 9.38 1 Yes Yes 5 3 2 1
R:R:F207 R:R:Y205 7.22 1 Yes Yes 4 3 2 1
R:R:L215 R:R:Y205 3.52 1 No Yes 5 3 2 1
L:L:?1 R:R:Y205 5.96 1 Yes Yes 0 3 0 1
R:R:F207 R:R:L215 10.96 1 Yes No 4 5 2 2
R:R:R216 R:R:V275 3.92 0 No No 3 5 1 2
R:R:K300 R:R:R216 3.71 0 No No 5 3 2 1
L:L:?1 R:R:R216 5.49 1 Yes No 0 3 0 1
L:L:?1 R:R:Q219 8.27 1 Yes No 0 5 0 1
R:R:W268 R:R:Y271 2.89 1 Yes Yes 9 6 2 1
R:R:H272 R:R:W268 5.29 1 Yes Yes 8 9 2 2
R:R:H272 R:R:Y271 7.62 1 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 8.83 0 No Yes 5 6 2 1
R:R:T303 R:R:Y271 6.24 0 No Yes 7 6 2 1
L:L:?1 R:R:Y271 13.25 1 Yes Yes 0 6 0 1
R:R:G305 R:R:S304 3.71 0 No No 5 5 2 1
R:R:S304 R:R:Y308 7.63 1 No No 5 6 1 1
L:L:?1 R:R:S304 5.09 1 Yes No 0 5 0 1
L:L:?1 R:R:Y308 6.62 1 Yes No 0 6 0 1
R:R:D297 R:R:D52 2.66 0 No Yes 4 5 2 1
R:R:L56 R:R:P57 1.64 1 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.73
Average Nodes In Shell40.00
Average Hubs In Shell17.00
Average Links In Shell59.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XYK A Protein Chemokine CXCR3 Homo Sapiens VUF10661 - Go1/Beta1/Gamma2 3.03 2025-02-26 To be published

A 2D representation of the interactions of A1L in 8XYK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D52 R:R:L56 2.71 0 Yes Yes 5 5 2 1
R:R:F55 R:R:L56 4.87 0 No Yes 4 5 2 1
R:R:F55 R:R:L59 7.31 0 No No 4 6 2 2
R:R:L56 R:R:Y60 5.86 2 Yes Yes 5 8 1 1
R:R:A113 R:R:L56 4.73 2 No Yes 5 5 1 1
L:L:?1 R:R:L56 3.13 2 Yes Yes 0 5 0 1
R:R:L59 R:R:Y60 5.86 0 No Yes 6 8 2 1
R:R:A110 R:R:Y60 4 0 No Yes 7 8 2 1
L:L:?1 R:R:Y60 5.96 2 Yes Yes 0 8 0 1
R:R:F131 R:R:L102 12.18 2 Yes No 5 6 1 2
R:R:T105 R:R:W109 4.85 2 No Yes 7 5 2 1
R:R:F131 R:R:T105 3.89 2 Yes No 5 7 1 2
R:R:W109 R:R:W117 6.56 2 Yes Yes 5 9 1 2
R:R:A127 R:R:W109 3.89 0 No Yes 5 5 2 1
R:R:G128 R:R:W109 2.81 0 No Yes 6 5 2 1
R:R:F131 R:R:W109 6.01 2 Yes Yes 5 5 1 1
R:R:C203 R:R:W109 5.22 2 Yes Yes 9 5 2 1
L:L:?1 R:R:W109 27.67 2 Yes Yes 0 5 0 1
L:L:?1 R:R:A113 5.34 2 Yes No 0 5 0 1
R:R:C203 R:R:W117 3.92 2 Yes Yes 9 9 2 2
R:R:F131 R:R:Y308 10.32 2 Yes No 5 6 1 1
L:L:?1 R:R:F131 9.63 2 Yes Yes 0 5 0 1
R:R:N132 R:R:Y136 6.98 2 Yes Yes 4 6 2 2
R:R:D186 R:R:N132 13.46 2 No Yes 4 4 2 2
R:R:N132 R:R:Y205 3.49 2 Yes Yes 4 3 2 1
R:R:N132 R:R:Q219 2.64 2 Yes No 4 5 2 1
R:R:F135 R:R:Y136 7.22 0 No Yes 7 6 1 2
R:R:F135 R:R:W268 6.01 0 No Yes 7 9 1 2
L:L:?1 R:R:F135 8.95 2 Yes No 0 7 0 1
R:R:Q219 R:R:Y136 6.76 2 No Yes 5 6 1 2
R:R:D186 R:R:Y205 11.49 2 No Yes 4 3 2 1
R:R:C203 R:R:L190 4.76 2 Yes Yes 9 5 2 2
R:R:L190 R:R:Y205 9.38 2 Yes Yes 5 3 2 1
R:R:F207 R:R:Y205 7.22 2 Yes Yes 4 3 2 1
R:R:L215 R:R:Y205 3.52 2 No Yes 5 3 2 1
L:L:?1 R:R:Y205 6.62 2 Yes Yes 0 3 0 1
R:R:F207 R:R:L215 10.96 2 Yes No 4 5 2 2
R:R:K300 R:R:R216 3.71 0 No No 5 3 2 1
L:L:?1 R:R:R216 4.12 2 Yes No 0 3 0 1
L:L:?1 R:R:Q219 9.02 2 Yes No 0 5 0 1
R:R:H272 R:R:W268 3.17 4 Yes Yes 8 9 2 2
R:R:H272 R:R:Y271 6.53 4 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 8.83 0 No Yes 5 6 2 1
R:R:T303 R:R:Y271 6.24 0 No Yes 7 6 2 1
L:L:?1 R:R:Y271 13.91 2 Yes Yes 0 6 0 1
R:R:S304 R:R:Y308 7.63 2 No No 5 6 1 1
L:L:?1 R:R:S304 5.09 2 Yes No 0 5 0 1
L:L:?1 R:R:Y308 6.62 2 Yes No 0 6 0 1
R:R:I279 R:R:R216 2.51 0 No No 5 3 2 1
R:R:G305 R:R:S304 1.86 0 No No 5 5 2 1
R:R:L56 R:R:P57 1.64 2 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.84
Average Nodes In Shell37.00
Average Hubs In Shell16.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y0H A Protein Chemokine CXCR3 Homo Sapiens VUF11418 - - 3.53 2025-02-26 To be published

A 2D representation of the interactions of A1L in 8Y0H
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L106 R:R:Y60 2.34 1 Yes Yes 8 8 2 2
R:R:W109 R:R:Y60 4.82 1 Yes Yes 5 8 1 2
R:R:F131 R:R:L102 10.96 1 Yes No 5 6 1 2
R:R:F131 R:R:T105 2.59 1 Yes No 5 7 1 2
R:R:T105 R:R:Y308 3.75 1 No Yes 7 6 2 1
R:R:L106 R:R:Y308 10.55 1 Yes Yes 8 6 2 1
R:R:S304 R:R:W109 8.65 1 No Yes 5 5 1 1
L:L:?1 R:R:W109 5.15 1 Yes Yes 0 5 0 1
R:R:F131 R:R:F135 5.36 1 Yes No 5 7 1 1
R:R:F131 R:R:Y308 6.19 1 Yes Yes 5 6 1 1
L:L:?1 R:R:F131 20.64 1 Yes Yes 0 5 0 1
R:R:F135 R:R:W268 8.02 1 No Yes 7 9 1 1
L:L:?1 R:R:F135 11.01 1 Yes No 0 7 0 1
R:R:A139 R:R:W268 2.59 0 No Yes 8 9 2 1
R:R:F224 R:R:W268 3.01 1 Yes Yes 8 9 2 1
R:R:F224 R:R:H272 21.5 1 Yes No 8 8 2 2
R:R:F264 R:R:W268 20.04 1 Yes Yes 9 9 2 1
R:R:H272 R:R:W268 5.29 1 No Yes 8 9 2 1
R:R:H310 R:R:W268 9.52 0 No Yes 9 9 2 1
L:L:?1 R:R:W268 3.86 1 Yes Yes 0 9 0 1
R:R:H272 R:R:Y271 7.62 1 No Yes 8 6 2 1
R:R:V275 R:R:Y271 5.05 1 No Yes 5 6 2 1
R:R:T303 R:R:Y271 4.99 0 No Yes 7 6 2 1
R:R:S304 R:R:Y271 2.54 1 No Yes 5 6 1 1
L:L:?1 R:R:Y271 15.9 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S304 5.94 1 Yes No 0 5 0 1
L:L:?1 R:R:G307 4.83 1 Yes No 0 8 0 1
L:L:?1 R:R:Y308 3.97 1 Yes Yes 0 6 0 1
R:R:A127 R:R:G128 1.95 0 No No 5 6 2 1
L:L:?1 R:R:G128 1.93 1 Yes No 0 6 0 1
R:R:G307 R:R:L306 1.71 0 No No 8 8 1 2
R:R:G305 R:R:W109 1.41 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.14
Average Nodes In Shell24.00
Average Hubs In Shell10.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y0N A Protein Chemokine CXCR3 Homo Sapiens VUF11418 - Go1/Beta1/Gamma2 3.07 2025-02-26 To be published

A 2D representation of the interactions of A1L in 8Y0N
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F131 R:R:L102 9.74 10 Yes No 5 6 1 2
R:R:L106 R:R:Y308 11.72 10 No No 8 6 2 1
R:R:S304 R:R:W109 8.65 0 No Yes 5 5 1 2
R:R:F131 R:R:F135 4.29 10 Yes No 5 7 1 1
R:R:F131 R:R:Y308 6.19 10 Yes No 5 6 1 1
L:L:?1 R:R:F131 20.64 10 Yes Yes 0 5 0 1
R:R:F135 R:R:W268 8.02 10 No Yes 7 9 1 1
L:L:?1 R:R:F135 6.19 10 Yes No 0 7 0 1
R:R:F224 R:R:W268 3.01 10 Yes Yes 8 9 2 1
R:R:F224 R:R:H272 22.63 10 Yes Yes 8 8 2 2
R:R:F264 R:R:W268 21.05 0 No Yes 9 9 2 1
R:R:H272 R:R:W268 4.23 10 Yes Yes 8 9 2 1
R:R:H310 R:R:W268 9.52 0 No Yes 9 9 2 1
L:L:?1 R:R:W268 4.5 10 Yes Yes 0 9 0 1
R:R:H272 R:R:Y271 7.62 10 Yes Yes 8 6 2 1
R:R:V275 R:R:Y271 5.05 0 No Yes 5 6 2 1
R:R:T303 R:R:Y271 4.99 0 No Yes 7 6 2 1
L:L:?1 R:R:Y271 17.88 10 Yes Yes 0 6 0 1
L:L:?1 R:R:S304 5.94 10 Yes No 0 5 0 1
L:L:?1 R:R:G307 5.8 10 Yes No 0 8 0 1
L:L:?1 R:R:Y308 3.31 10 Yes No 0 6 0 1
R:R:F131 R:R:T105 2.59 10 Yes No 5 7 1 2
R:R:A139 R:R:W268 2.59 0 No Yes 8 9 2 1
R:R:A127 R:R:G128 1.95 0 No No 5 6 2 1
L:L:?1 R:R:G128 1.93 10 Yes No 0 6 0 1
R:R:G307 R:R:L306 1.71 0 No No 8 8 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.27
Average Nodes In Shell22.00
Average Hubs In Shell7.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y45 A Peptide Opioid DOP Homo Sapiens ADL5859 - Gi2/Beta1/Gamma2 3.45 2024-11-27 doi.org/10.1038/s41467-024-52601-1

A 2D representation of the interactions of A1L in 8Y45
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D128 11.5 3 Yes No 0 5 0 1
L:L:?1 R:R:Y129 17.22 3 Yes No 0 5 0 1
L:L:?1 R:R:M132 11.18 3 Yes No 0 8 0 1
L:L:?1 R:R:K214 2.39 3 Yes No 0 5 0 1
L:L:?1 R:R:I277 4.03 3 Yes No 0 5 0 1
L:L:?1 R:R:V281 3.37 3 Yes No 0 6 0 1
L:L:?1 R:R:W284 7.08 3 Yes No 0 4 0 1
L:L:?1 R:R:L300 10.17 3 Yes No 0 5 0 1
L:L:?1 R:R:I304 8.06 3 Yes Yes 0 5 0 1
L:L:?1 R:R:Y308 7.29 3 Yes Yes 0 7 0 1
R:R:D128 R:R:T101 10.12 3 No Yes 5 7 1 2
R:R:T101 R:R:Y308 6.24 3 Yes Yes 7 7 2 1
R:R:L102 R:R:Y308 16.41 3 No Yes 7 7 2 1
R:R:D128 R:R:Y308 10.34 3 No Yes 5 7 1 1
R:R:I183 R:R:Y129 3.63 0 No No 4 5 2 1
R:R:M132 R:R:W274 3.49 0 No Yes 8 8 1 2
R:R:K214 R:R:V281 9.11 3 No No 5 6 1 1
R:R:G307 R:R:I277 1.76 0 No No 7 5 2 1
R:R:R291 R:R:W284 3 0 No No 1 4 2 1
R:R:H301 R:R:L300 2.57 3 Yes No 4 5 2 1
R:R:I304 R:R:L300 7.14 3 Yes No 5 5 1 1
R:R:H301 R:R:I304 2.65 3 Yes Yes 4 5 2 1
R:R:C303 R:R:I277 1.64 0 No No 6 5 2 1
R:R:C303 R:R:I304 1.64 0 No Yes 6 5 2 1
R:R:K214 R:R:T285 1.5 3 No No 5 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.23
Average Nodes In Shell20.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y63 A Peptide Formylpeptide FPR2-ALX Homo Sapiens C20:0 Ceramide - Gi1/Beta1/Gamma2 3.2 2025-02-05 To be published

A 2D representation of the interactions of A1L in 8Y63
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y175 5.3 0 No Yes 0 3 0 1
L:L:?1 R:R:T177 6.66 0 No No 0 3 0 1
L:L:?1 R:R:R205 10.3 0 No Yes 0 5 0 1
R:R:D173 R:R:K90 15.21 18 No No 3 4 2 2
R:R:K90 R:R:Y175 11.94 18 No Yes 4 3 2 1
R:R:T177 R:R:V167 3.17 0 No No 3 1 1 2
R:R:D173 R:R:I169 9.8 18 No Yes 3 1 2 2
R:R:I169 R:R:Y175 3.63 18 Yes Yes 1 3 2 1
R:R:D173 R:R:Y175 21.84 18 No Yes 3 3 2 1
R:R:R201 R:R:R205 7.46 5 Yes Yes 5 5 2 1
R:R:F257 R:R:R205 3.21 5 Yes Yes 7 5 2 1
R:R:Q258 R:R:R205 7.01 5 Yes Yes 8 5 2 1
R:R:A261 R:R:R205 5.53 0 No Yes 5 5 2 1
R:R:F257 R:R:Q258 5.86 5 Yes Yes 7 8 2 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.42
Average Nodes In Shell12.00
Average Hubs In Shell6.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YIC A Lipid Lysophospholipid S1P1 Homo Sapiens SAR247799 - Gi1/Beta1/Gamma2 3.47 2024-12-11 To be published

A 2D representation of the interactions of A1L in 8YIC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:N101 3.88 1 Yes No 0 5 0 1
L:L:?1 R:R:T108 4.16 1 Yes No 0 4 0 1
L:L:?1 R:R:E121 8.98 1 Yes Yes 0 5 0 1
L:L:?1 R:R:M124 6.39 1 Yes No 0 6 0 1
L:L:?1 R:R:F125 24.08 1 Yes No 0 5 0 1
L:L:?1 R:R:L128 10.17 1 Yes No 0 6 0 1
L:L:?1 R:R:S129 2.54 1 Yes Yes 0 6 0 1
L:L:?1 R:R:L195 8.6 1 Yes No 0 3 0 1
L:L:?1 R:R:L272 3.91 1 Yes No 0 6 0 1
L:L:?1 R:R:L297 4.69 1 Yes No 0 5 0 1
R:R:T108 R:R:Y29 3.75 0 No Yes 4 7 1 2
R:R:W117 R:R:Y29 5.79 1 No Yes 9 7 2 2
R:R:M124 R:R:Y98 3.59 1 No Yes 6 6 1 2
R:R:L297 R:R:Y98 5.86 0 No Yes 5 6 1 2
R:R:N101 R:R:R120 3.62 1 No Yes 5 6 1 2
R:R:M124 R:R:N101 4.21 1 No No 6 5 1 1
R:R:R120 R:R:T108 6.47 0 Yes No 6 4 2 1
R:R:E121 R:R:W117 9.81 1 Yes No 5 9 1 2
R:R:E121 R:R:R120 5.82 1 Yes Yes 5 6 1 2
R:R:E121 R:R:L195 3.98 1 Yes No 5 3 1 1
R:R:E121 R:R:Y198 6.73 1 Yes Yes 5 4 1 2
R:R:F125 R:R:Y202 9.28 1 No Yes 5 7 1 2
R:R:C206 R:R:F125 2.79 1 No No 6 5 2 1
R:R:F133 R:R:S129 5.28 1 Yes Yes 5 6 2 1
R:R:S129 R:R:S171 6.52 1 Yes No 6 8 1 2
R:R:L174 R:R:S129 3 1 No Yes 5 6 2 1
R:R:F133 R:R:S171 5.28 1 Yes No 5 8 2 2
R:R:L174 R:R:Y202 7.03 1 No Yes 5 7 2 2
R:R:C206 R:R:L174 4.76 1 No No 6 5 2 2
R:R:L195 R:R:V194 2.98 1 No No 3 4 1 2
R:R:Y198 R:R:Y202 2.98 1 Yes Yes 4 7 2 2
R:R:C206 R:R:Y202 9.41 1 No Yes 6 7 2 2
L:L:?1 R:R:S105 0.85 1 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.11
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YKV A Alicarboxylic acid Succinate Succinate Homo Sapiens PubChem 137553168 - Gi1/Beta1/Gamma2 2.48 2024-05-29 doi.org/10.1038/s41422-024-00984-7

A 2D representation of the interactions of A1L in 8YKV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Y30 3.97 2 Yes Yes 0 8 0 1
L:L:?1 R:R:L79 7.82 2 Yes No 0 6 0 1
L:L:?1 R:R:Y83 7.29 2 Yes No 0 5 0 1
L:L:?1 R:R:W88 7.08 2 Yes Yes 0 8 0 1
L:L:?1 R:R:N98 3.88 2 Yes No 0 4 0 1
L:L:?1 R:R:R99 10.3 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L102 10.17 2 Yes Yes 0 7 0 1
L:L:?1 R:R:H103 8.72 2 Yes Yes 0 5 0 1
L:L:?1 R:R:D174 3.83 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R281 5.49 2 Yes Yes 0 6 0 1
R:R:L26 R:R:Y30 8.21 2 Yes Yes 6 8 2 1
R:R:L26 R:R:Y83 12.89 2 Yes No 6 5 2 1
R:R:I278 R:R:L26 4.28 0 Yes Yes 4 6 2 2
R:R:L26 R:R:P282 3.28 2 Yes Yes 6 5 2 2
R:R:L76 R:R:Y30 5.86 0 No Yes 8 8 2 1
R:R:L79 R:R:Y30 9.38 2 No Yes 6 8 1 1
R:R:I80 R:R:Y30 3.63 0 No Yes 6 8 2 1
R:R:R281 R:R:Y30 4.12 2 Yes Yes 6 8 1 1
R:R:P282 R:R:Y30 8.34 2 Yes Yes 5 8 2 1
R:R:F285 R:R:Y30 7.22 2 Yes Yes 7 8 2 1
R:R:F72 R:R:L102 9.74 0 Yes Yes 7 7 2 1
R:R:F285 R:R:F72 11.79 2 Yes Yes 7 7 2 2
R:R:N98 R:R:T75 8.77 0 No No 4 6 1 2
R:R:L102 R:R:T75 7.37 2 Yes No 7 6 1 2
R:R:M78 R:R:W88 4.65 2 No Yes 7 8 2 1
R:R:M78 R:R:Y90 10.78 2 No Yes 7 7 2 2
R:R:M78 R:R:N98 9.82 2 No No 7 4 2 1
R:R:L79 R:R:Y83 5.86 2 No No 6 5 1 1
R:R:S82 R:R:W88 8.65 0 No Yes 5 8 2 1
R:R:W88 R:R:Y90 11.58 2 Yes Yes 8 7 1 2
R:R:G91 R:R:W88 2.81 0 No Yes 8 8 2 1
R:R:C95 R:R:W88 6.53 0 No Yes 9 8 2 1
R:R:C95 R:R:R99 4.18 0 No Yes 9 6 2 1
R:R:I157 R:R:R99 3.76 2 Yes Yes 4 6 2 1
R:R:H103 R:R:L102 3.86 2 Yes Yes 5 7 1 1
R:R:H103 R:R:I157 3.98 2 Yes Yes 5 4 1 2
R:R:F175 R:R:H103 5.66 2 Yes Yes 4 5 2 1
R:R:F175 R:R:I157 7.54 2 Yes Yes 4 4 2 2
R:R:D174 R:R:S177 10.31 2 Yes No 5 4 1 2
R:R:D174 R:R:R281 3.57 2 Yes Yes 5 6 1 1
R:R:Y248 R:R:Y277 8.94 2 Yes Yes 7 5 2 2
R:R:R281 R:R:Y248 5.14 2 Yes Yes 6 7 1 2
R:R:F285 R:R:Y248 6.19 2 Yes Yes 7 7 2 2
R:R:R281 R:R:Y277 18.52 2 Yes Yes 6 5 1 2
R:R:I278 R:R:R281 3.76 0 Yes Yes 4 6 2 1
R:R:P282 R:R:R281 2.88 2 Yes Yes 5 6 2 1
R:R:F285 R:R:R281 6.41 2 Yes Yes 7 6 2 1
R:R:I96 R:R:R99 2.51 0 No Yes 7 6 2 1
R:R:D174 R:R:S178 1.47 2 Yes No 5 3 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength6.85
Average Nodes In Shell31.00
Average Hubs In Shell18.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN7 A Amine Histamine H3 Homo Sapiens Immethridine - Go1/Beta1/Gamma2 2.77 2024-10-16  10.2210/pdb8YN7/pdb

A 2D representation of the interactions of A1L in 8YN7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D114 6.9 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y115 11.92 1 Yes Yes 0 9 0 1
L:L:?1 R:R:C118 5.38 1 Yes No 0 8 0 1
L:L:?1 R:R:E206 6.74 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y374 13.25 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F398 17.2 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L401 10.17 1 Yes No 0 8 0 1
L:L:?1 R:R:W402 8.37 1 Yes Yes 0 8 0 1
R:R:V83 R:R:W402 3.68 0 Yes Yes 9 8 2 1
R:R:C87 R:R:D114 9.34 0 No Yes 9 9 2 1
R:R:I88 R:R:W402 18.79 1 Yes Yes 9 8 2 1
R:R:W110 R:R:Y91 11.58 0 Yes Yes 6 8 2 2
R:R:E395 R:R:Y91 6.73 1 Yes Yes 6 8 2 2
R:R:F398 R:R:Y91 12.38 1 Yes Yes 7 8 1 2
R:R:W402 R:R:Y91 8.68 1 Yes Yes 8 8 1 2
R:R:D114 R:R:W110 7.82 1 Yes Yes 9 6 1 2
R:R:D114 R:R:W402 11.17 1 Yes Yes 9 8 1 1
R:R:Y115 R:R:Y167 15.89 1 Yes Yes 9 8 1 2
R:R:I171 R:R:Y115 4.84 1 Yes Yes 7 9 2 1
R:R:F192 R:R:Y115 4.13 1 Yes Yes 7 9 2 1
R:R:E206 R:R:T119 14.11 0 Yes No 8 9 1 2
R:R:F192 R:R:Y167 5.16 1 Yes Yes 7 8 2 2
R:R:E206 R:R:Y167 15.71 0 Yes Yes 8 8 1 2
R:R:F192 R:R:I171 3.77 1 Yes Yes 7 7 2 2
R:R:E206 R:R:W371 7.63 0 Yes Yes 8 8 1 2
R:R:L401 R:R:W371 13.67 1 No Yes 8 8 1 2
R:R:M378 R:R:Y374 15.57 1 No Yes 8 9 2 1
R:R:Y374 R:R:Y394 7.94 1 Yes Yes 9 4 1 2
R:R:S397 R:R:Y374 7.63 0 No Yes 7 9 2 1
R:R:F398 R:R:Y374 10.32 1 Yes Yes 7 9 1 1
R:R:L401 R:R:Y374 4.69 1 No Yes 8 9 1 1
R:R:E395 R:R:Y394 6.73 1 Yes Yes 6 4 2 2
R:R:F398 R:R:Y394 6.19 1 Yes Yes 7 4 1 2
R:R:E395 R:R:F398 3.5 1 Yes Yes 6 7 2 1
R:R:E395 R:R:W399 4.36 1 Yes No 6 9 2 2
R:R:F398 R:R:W402 11.02 1 Yes Yes 7 8 1 1
R:R:W399 R:R:W402 7.5 0 No Yes 9 8 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.99
Average Nodes In Shell24.00
Average Hubs In Shell17.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN8 A Amine Histamine H3 Homo Sapiens Proxyfan - Go1/Beta1/Gamma2 2.77 2024-10-16  10.2210/pdb8YN7/pdb

A 2D representation of the interactions of A1L in 8YN8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D114 6.9 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y115 8.61 1 Yes Yes 0 9 0 1
L:L:?1 R:R:C118 7.17 1 Yes No 0 8 0 1
L:L:?1 R:R:Y167 6.62 1 Yes Yes 0 8 0 1
L:L:?1 R:R:E206 9.73 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y374 9.27 1 Yes Yes 0 9 0 1
L:L:?1 R:R:T375 5.83 1 Yes No 0 8 0 1
L:L:?1 R:R:F398 14.45 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L401 10.95 1 Yes No 0 8 0 1
L:L:?1 R:R:W402 7.08 1 Yes Yes 0 8 0 1
R:R:I88 R:R:V83 3.07 1 Yes Yes 9 9 2 2
R:R:V83 R:R:W402 3.68 1 Yes Yes 9 8 2 1
R:R:C87 R:R:D114 6.22 0 No Yes 9 9 2 1
R:R:I88 R:R:W402 17.62 1 Yes Yes 9 8 2 1
R:R:W110 R:R:Y91 10.61 1 Yes Yes 6 8 2 2
R:R:F398 R:R:Y91 12.38 1 Yes Yes 7 8 1 2
R:R:W399 R:R:Y91 4.82 1 Yes Yes 9 8 2 2
R:R:W402 R:R:Y91 8.68 1 Yes Yes 8 8 1 2
R:R:D114 R:R:W110 6.7 1 Yes Yes 9 6 1 2
R:R:W110 R:R:W402 3.75 1 Yes Yes 6 8 2 1
R:R:D114 R:R:W402 11.17 1 Yes Yes 9 8 1 1
R:R:Y115 R:R:Y167 8.94 1 Yes Yes 9 8 1 1
R:R:I171 R:R:Y115 3.63 1 No Yes 7 9 2 1
R:R:F192 R:R:Y115 6.19 1 Yes Yes 7 9 2 1
R:R:E206 R:R:T119 12.7 1 Yes No 8 9 1 2
R:R:L166 R:R:Y167 10.55 0 No Yes 8 8 2 1
R:R:F192 R:R:Y167 5.16 1 Yes Yes 7 8 2 1
R:R:F198 R:R:Y167 4.13 1 Yes Yes 7 8 2 1
R:R:A202 R:R:Y167 4 1 No Yes 9 8 2 1
R:R:E206 R:R:Y167 8.98 1 Yes Yes 8 8 1 1
R:R:F192 R:R:I171 5.02 1 Yes No 7 7 2 2
R:R:F192 R:R:F198 16.08 1 Yes Yes 7 7 2 2
R:R:A202 R:R:F198 4.16 1 No Yes 9 7 2 2
R:R:E206 R:R:W371 7.63 1 Yes Yes 8 8 1 2
R:R:F207 R:R:W371 7.02 1 Yes Yes 9 8 2 2
R:R:F207 R:R:T375 12.97 1 Yes No 9 8 2 1
R:R:L401 R:R:W371 15.94 1 No Yes 8 8 1 2
R:R:M378 R:R:Y374 17.96 1 No Yes 8 9 2 1
R:R:S397 R:R:Y374 6.36 0 No Yes 7 9 2 1
R:R:F398 R:R:Y374 8.25 1 Yes Yes 7 9 1 1
R:R:L401 R:R:Y374 5.86 1 No Yes 8 9 1 1
R:R:F398 R:R:Y394 5.16 1 Yes No 7 4 1 2
R:R:F398 R:R:W402 10.02 1 Yes Yes 7 8 1 1
R:R:W399 R:R:W402 11.25 1 Yes Yes 9 8 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.66
Average Nodes In Shell28.00
Average Hubs In Shell17.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YNA A Amine Histamine H4 Homo Sapiens Immepip - Gi1/Beta1/Gamma 2.63 2024-10-16  10.2210/pdb8YN7/pdb

A 2D representation of the interactions of A1L in 8YNA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D94 6.13 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y95 15.23 1 Yes Yes 0 8 0 1
L:L:?1 R:R:C98 3.59 1 Yes No 0 8 0 1
L:L:?1 R:R:E182 5.99 1 Yes Yes 0 8 0 1
L:L:?1 R:R:W316 5.79 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y319 4.64 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F344 14.45 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q347 14.29 1 Yes No 0 8 0 1
L:L:?1 R:R:W348 8.37 1 Yes Yes 0 8 0 1
R:R:I69 R:R:V64 3.07 1 Yes Yes 8 8 2 2
R:R:V64 R:R:W348 3.68 1 Yes Yes 8 8 2 1
R:R:D94 R:R:S68 8.83 1 Yes No 8 8 1 2
R:R:S68 R:R:W348 3.71 1 No Yes 8 8 2 1
R:R:I69 R:R:W345 3.52 1 Yes Yes 8 8 2 2
R:R:I69 R:R:W348 8.22 1 Yes Yes 8 8 2 1
R:R:F344 R:R:Y72 9.28 1 Yes Yes 6 7 1 2
R:R:W345 R:R:Y72 5.79 1 Yes Yes 8 7 2 2
R:R:W348 R:R:Y72 9.65 1 Yes Yes 8 7 1 2
R:R:C98 R:R:D94 3.11 1 No Yes 8 8 1 1
R:R:D94 R:R:W348 11.17 1 Yes Yes 8 8 1 1
R:R:N147 R:R:Y95 12.79 1 Yes Yes 8 8 2 1
R:R:I151 R:R:Y95 7.25 0 No Yes 7 8 2 1
R:R:P166 R:R:Y95 11.13 1 Yes Yes 7 8 2 1
R:R:N147 R:R:T99 5.85 1 Yes Yes 8 8 2 2
R:R:E182 R:R:T99 5.64 1 Yes Yes 8 8 1 2
R:R:F312 R:R:V102 9.18 1 No No 9 8 2 2
R:R:V102 R:R:W316 8.58 1 No Yes 8 9 2 1
R:R:E182 R:R:N147 7.89 1 Yes Yes 8 8 1 2
R:R:E182 R:R:W316 9.81 1 Yes Yes 8 9 1 1
R:R:F183 R:R:W316 6.01 0 Yes Yes 9 9 2 1
R:R:F312 R:R:W316 7.02 1 No Yes 9 9 2 1
R:R:Q347 R:R:W316 27.38 1 No Yes 8 9 1 1
R:R:T323 R:R:Y319 8.74 1 No Yes 7 7 2 1
R:R:Y319 R:R:Y340 10.92 1 Yes Yes 7 5 1 2
R:R:F344 R:R:Y319 9.28 1 Yes Yes 6 7 1 1
R:R:Q347 R:R:Y319 6.76 1 No Yes 8 7 1 1
R:R:T323 R:R:Y340 3.75 1 No Yes 7 5 2 2
R:R:F344 R:R:W348 10.02 1 Yes Yes 6 8 1 1
R:R:W345 R:R:W348 9.37 1 Yes Yes 8 8 2 1
R:R:A343 R:R:Y319 2.67 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.72
Average Nodes In Shell25.00
Average Hubs In Shell17.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YRG A Orphan Orphan MRGPRX4 Homo Sapiens Fospropofol - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.14 2024-05-22  10.1126/scitranslmed.adk8198

A 2D representation of the interactions of A1L in 8YRG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R82 8.24 4 Yes Yes 0 4 0 1
L:L:?1 R:R:R86 8.24 4 Yes Yes 0 3 0 1
L:L:?1 R:R:H92 4.36 4 Yes No 0 6 0 1
L:L:?1 R:R:R95 7.55 4 Yes Yes 0 7 0 1
L:L:?1 R:R:K96 15.93 4 Yes No 0 5 0 1
L:L:?1 R:R:V99 2.53 4 Yes Yes 0 5 0 1
L:L:?1 R:R:Y250 22.52 4 Yes No 0 3 0 1
L:L:?1 R:R:Y254 5.3 4 Yes Yes 0 3 0 1
R:R:R86 R:R:T27 16.82 4 Yes No 3 2 1 2
R:R:R86 R:R:T31 2.59 4 Yes No 3 4 1 2
R:R:Q79 R:R:R82 5.84 4 Yes Yes 6 4 2 1
R:R:M102 R:R:Q79 4.08 4 Yes Yes 4 6 2 2
R:R:M258 R:R:Q79 13.59 4 Yes Yes 4 6 2 2
R:R:L98 R:R:R82 14.58 4 No Yes 4 4 2 1
R:R:R82 R:R:V99 5.23 4 Yes Yes 4 5 1 1
R:R:M102 R:R:R82 8.69 4 Yes Yes 4 4 2 1
R:R:I90 R:R:L85 14.27 4 No No 3 4 2 2
R:R:L85 R:R:R95 3.64 4 No Yes 4 7 2 1
R:R:R86 R:R:Y250 7.2 4 Yes No 3 3 1 1
R:R:I90 R:R:R95 6.26 4 No Yes 3 7 2 1
R:R:H92 R:R:R95 2.26 4 No Yes 6 7 1 1
R:R:V99 R:R:W158 6.13 4 Yes Yes 5 3 1 2
R:R:V99 R:R:Y254 2.52 4 Yes Yes 5 3 1 1
R:R:M102 R:R:M258 2.89 4 Yes Yes 4 4 2 2
R:R:L235 R:R:W158 6.83 4 Yes Yes 3 3 2 2
R:R:W158 R:R:Y254 4.82 4 Yes Yes 3 3 2 1
R:R:L235 R:R:Y254 3.52 4 Yes Yes 3 3 2 1
R:R:M258 R:R:Y254 5.99 4 Yes Yes 4 3 2 1
R:R:C251 R:R:Y250 1.34 0 No No 2 3 2 1
R:R:N89 R:R:R95 1.21 0 No Yes 3 7 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.33
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YUV A Amine Histamine H3 Homo Sapiens Immepip - Gi1/Beta1/Gamma2 3  2024-06-05  10.1002/advs.202310120

A 2D representation of the interactions of A1L in 8YUV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I88 R:R:V83 3.07 2 Yes Yes 9 9 2 2
R:R:V83 R:R:W402 6.13 2 Yes Yes 9 8 2 1
R:R:C87 R:R:D114 6.22 2 No Yes 9 9 2 1
R:R:C87 R:R:W402 3.92 2 No Yes 9 8 2 1
R:R:I88 R:R:W399 3.52 2 Yes Yes 9 9 2 2
R:R:I88 R:R:W402 9.4 2 Yes Yes 9 8 2 1
R:R:W110 R:R:Y91 10.61 0 Yes Yes 6 8 2 2
R:R:F398 R:R:Y91 10.32 2 Yes Yes 7 8 1 2
R:R:W399 R:R:Y91 5.79 2 Yes Yes 9 8 2 2
R:R:W402 R:R:Y91 7.72 2 Yes Yes 8 8 1 2
R:R:L111 R:R:W110 4.56 2 Yes Yes 7 6 2 2
R:R:D114 R:R:W110 7.82 2 Yes Yes 9 6 1 2
R:R:L111 R:R:Y115 3.52 2 Yes Yes 7 9 2 1
R:R:I171 R:R:L111 2.85 2 Yes Yes 7 7 2 2
R:R:D114 R:R:Y115 3.45 2 Yes Yes 9 9 1 1
R:R:C118 R:R:D114 3.11 2 No Yes 8 9 1 1
R:R:D114 R:R:W402 10.05 2 Yes Yes 9 8 1 1
L:L:?1 R:R:D114 6.9 2 Yes Yes 0 9 0 1
R:R:Y115 R:R:Y167 6.95 2 Yes Yes 9 8 1 2
R:R:I171 R:R:Y115 3.63 2 Yes Yes 7 9 2 1
R:R:F193 R:R:Y115 9.28 2 Yes Yes 5 9 2 1
L:L:?1 R:R:Y115 13.25 2 Yes Yes 0 9 0 1
R:R:C118 R:R:W402 2.61 2 No Yes 8 8 1 1
L:L:?1 R:R:C118 5.38 2 Yes No 0 8 0 1
R:R:E206 R:R:T119 14.11 2 Yes No 8 9 1 2
R:R:L166 R:R:Y167 9.38 2 No Yes 8 8 2 2
R:R:E206 R:R:L166 2.65 2 Yes No 8 8 1 2
R:R:E206 R:R:Y167 11.22 2 Yes Yes 8 8 1 2
R:R:F193 R:R:M378 11.2 2 Yes Yes 5 8 2 2
R:R:E206 R:R:W371 7.63 2 Yes Yes 8 8 1 2
L:L:?1 R:R:E206 8.24 2 Yes Yes 0 8 0 1
R:R:L401 R:R:W371 7.97 2 No Yes 8 8 1 2
R:R:M378 R:R:Y374 9.58 2 Yes Yes 8 9 2 1
R:R:Y374 R:R:Y394 10.92 2 Yes No 9 4 1 2
R:R:S397 R:R:Y374 2.54 0 No Yes 7 9 2 1
R:R:F398 R:R:Y374 5.16 2 Yes Yes 7 9 1 1
R:R:L401 R:R:Y374 9.38 2 No Yes 8 9 1 1
L:L:?1 R:R:Y374 7.95 2 Yes Yes 0 9 0 1
R:R:M378 R:R:Y394 3.59 2 Yes No 8 4 2 2
R:R:F398 R:R:W399 4.01 2 Yes Yes 7 9 1 2
R:R:F398 R:R:W402 14.03 2 Yes Yes 7 8 1 1
L:L:?1 R:R:F398 14.45 2 Yes Yes 0 7 0 1
R:R:W399 R:R:W402 11.25 2 Yes Yes 9 8 2 1
L:L:?1 R:R:L401 9.38 2 Yes No 0 8 0 1
L:L:?1 R:R:W402 5.15 2 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.84
Average Nodes In Shell25.00
Average Hubs In Shell18.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZMF A Amine 5-Hydroxytryptamine 5-HT2C Homo Sapiens A1L10 - - 3.6 2024-08-28  10.1021/acs.jmedchem.4c01244

A 2D representation of the interactions of A1L in 8ZMF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V106 R:R:W130 3.68 1 No Yes 7 5 2 2
R:R:D134 R:R:V106 7.3 1 Yes No 8 7 1 2
R:R:V106 R:R:Y358 6.31 1 No Yes 7 8 2 1
R:R:M107 R:R:W355 8.14 1 Yes Yes 8 7 2 2
R:R:M107 R:R:Y358 4.79 1 Yes Yes 8 8 2 1
R:R:W130 R:R:Y358 3.86 1 Yes Yes 5 8 2 1
R:R:D134 R:R:S138 4.42 1 Yes No 8 6 1 1
R:R:D134 R:R:Y358 10.34 1 Yes Yes 8 8 1 1
L:L:?1 R:R:D134 15.34 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V135 5.89 1 Yes No 0 6 0 1
L:L:?1 R:R:S138 9.33 1 Yes No 0 6 0 1
R:R:F223 R:R:I142 5.02 0 Yes Yes 8 8 2 1
R:R:I142 R:R:P226 8.47 0 Yes Yes 8 9 1 2
R:R:F320 R:R:I142 8.79 1 Yes Yes 9 8 2 1
L:L:?1 R:R:I142 4.03 1 Yes Yes 0 8 0 1
L:L:?1 R:R:I189 5.64 1 Yes No 0 6 0 1
R:R:L209 R:R:V215 4.47 0 No No 5 6 1 2
L:L:?1 R:R:L209 3.91 1 Yes No 0 5 0 1
L:L:?1 R:R:G218 7.73 1 Yes No 0 7 0 1
R:R:F328 R:R:S219 5.28 1 Yes No 7 7 1 2
R:R:F223 R:R:F328 35.37 0 Yes Yes 8 7 2 1
R:R:F320 R:R:W324 11.02 1 Yes Yes 9 8 2 1
R:R:F320 R:R:N360 13.29 1 Yes No 9 9 2 2
R:R:F327 R:R:W324 7.02 1 Yes Yes 7 8 1 1
R:R:F328 R:R:W324 4.01 1 Yes Yes 7 8 1 1
R:R:G357 R:R:W324 12.67 0 No Yes 7 8 2 1
R:R:N360 R:R:W324 6.78 1 No Yes 9 8 2 1
L:L:?1 R:R:W324 10.94 1 Yes Yes 0 8 0 1
R:R:F327 R:R:F328 5.36 1 Yes Yes 7 7 1 1
L:L:?1 R:R:F327 8.95 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F328 12.39 1 Yes Yes 0 7 0 1
R:R:V354 R:R:Y358 6.31 0 No Yes 7 8 2 1
R:R:W355 R:R:Y358 9.65 1 Yes Yes 7 8 2 1
L:L:?1 R:R:Y358 3.97 1 Yes Yes 0 8 0 1
R:R:F327 R:R:L350 3.65 1 Yes No 7 4 1 2
R:R:I189 R:R:P190 3.39 0 No No 6 7 1 2
L:L:?1 R:R:V185 3.37 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.62
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZMG A Amine 5-Hydroxytryptamine 5-HT2A Homo Sapiens Pimavanserin - - 3.4 2024-08-28  10.1021/acs.jmedchem.4c01244

A 2D representation of the interactions of A1L in 8ZMG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D155 16.1 1 Yes No 0 8 0 1
L:L:?1 R:R:V156 8.42 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S159 10.18 1 Yes No 0 7 0 1
L:L:?1 R:R:I210 11.29 1 Yes No 0 6 0 1
L:L:?1 R:R:F234 4.82 1 Yes Yes 0 7 0 1
L:L:?1 R:R:G238 7.73 1 Yes No 0 6 0 1
L:L:?1 R:R:S242 3.39 1 Yes No 0 6 0 1
L:L:?1 R:R:W336 10.3 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F339 3.44 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 8.95 1 Yes Yes 0 7 0 1
R:R:D155 R:R:V127 7.3 1 No Yes 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 Yes Yes 8 7 2 2
R:R:D155 R:R:Y370 4.6 1 No Yes 8 7 1 2
R:R:T160 R:R:V156 3.17 1 Yes Yes 7 6 2 1
R:R:S207 R:R:V156 6.46 0 No Yes 7 6 2 1
R:R:I210 R:R:V156 4.61 1 No Yes 6 6 1 1
R:R:S159 R:R:W336 4.94 1 No Yes 7 8 1 1
R:R:I206 R:R:T160 4.56 1 No Yes 6 7 2 2
R:R:S242 R:R:T160 4.8 1 No Yes 6 7 1 2
R:R:I206 R:R:S242 3.1 1 No No 6 6 2 1
R:R:I210 R:R:P211 5.08 1 No No 6 5 1 2
R:R:F213 R:R:K220 6.2 1 No Yes 4 3 2 2
R:R:F213 R:R:F234 8.57 1 No Yes 4 7 2 1
R:R:D231 R:R:K220 4.15 1 No Yes 5 3 2 2
R:R:F234 R:R:K220 9.93 1 Yes Yes 7 3 1 2
R:R:D231 R:R:F234 9.55 1 No Yes 5 7 2 1
R:R:G238 R:R:I237 3.53 0 No No 6 4 1 2
R:R:F340 R:R:S239 7.93 1 Yes No 7 6 1 2
R:R:F243 R:R:W336 4.01 1 Yes Yes 8 8 2 1
R:R:F243 R:R:F340 17.15 1 Yes Yes 8 7 2 1
R:R:F332 R:R:W336 10.02 0 Yes Yes 9 8 2 1
R:R:F339 R:R:W336 6.01 1 Yes Yes 7 8 1 1
R:R:F340 R:R:W336 6.01 1 Yes Yes 7 8 1 1
R:R:G369 R:R:W336 5.63 0 No Yes 7 8 2 1
R:R:F339 R:R:F365 3.22 1 Yes Yes 7 5 1 2
R:R:F339 R:R:V366 3.93 1 Yes No 7 6 1 2
R:R:V366 R:R:Y370 7.57 0 No Yes 6 7 2 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.46
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IYA A Lipid GPR55 GPR55 Homo Sapiens ONO-9710531 - - 3.04  2025-01-01  10.1038/s41422-024-01046-8

A 2D representation of the interactions of A1L in 9IYA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C94 R:R:H170 4.42 0 No Yes 9 5 2 1
R:R:H170 R:R:T95 5.48 2 Yes No 5 7 1 2
R:R:E98 R:R:F102 3.5 2 No No 6 5 1 1
R:R:E98 R:R:H170 7.39 2 No Yes 6 5 1 1
L:L:?1 R:R:E98 10.48 2 Yes No 0 6 0 1
R:R:C99 R:R:I156 8.18 0 No No 5 4 2 1
L:L:?1 R:R:F102 26.84 2 Yes No 0 5 0 1
R:R:H243 R:R:Y106 7.62 1 Yes No 8 8 2 1
L:L:?1 R:R:Y106 13.25 2 Yes No 0 8 0 1
R:R:I156 R:R:Y157 9.67 0 No No 4 4 1 2
L:L:?1 R:R:I156 16.13 2 Yes No 0 4 0 1
R:R:S158 R:R:T176 6.4 0 No No 3 2 2 1
R:R:F159 R:R:M172 6.22 0 No Yes 4 4 2 1
R:R:H170 R:R:K165 6.55 2 Yes No 5 2 1 2
R:R:K165 R:R:M172 4.32 0 No Yes 2 4 2 1
L:L:?1 R:R:H170 12.35 2 Yes Yes 0 5 0 1
R:R:N171 R:R:W177 5.65 2 Yes Yes 4 3 2 1
R:R:N171 R:R:Q249 6.6 2 Yes No 4 5 2 2
R:R:N171 R:R:R253 10.85 2 Yes No 4 4 2 2
R:R:M172 R:R:T176 9.03 2 Yes No 4 2 1 1
L:L:?1 R:R:M172 9.58 2 Yes Yes 0 4 0 1
L:L:?1 R:R:T176 5.83 2 Yes No 0 2 0 1
R:R:Q249 R:R:W177 6.57 2 No Yes 5 3 2 1
R:R:R253 R:R:W177 12 2 No Yes 4 3 2 1
L:L:?1 R:R:W177 12.23 2 Yes Yes 0 3 0 1
L:L:?1 R:R:L185 14.86 2 Yes No 0 5 0 1
R:R:H243 R:R:V242 4.15 1 Yes Yes 8 7 2 2
R:R:F246 R:R:V242 3.93 0 No Yes 6 7 1 2
R:R:F246 R:R:M274 3.73 0 No No 6 6 1 2
L:L:?1 R:R:F246 4.82 2 Yes No 0 6 0 1
R:R:I154 R:R:P155 3.39 0 No No 4 7 2 1
L:L:?1 R:R:P155 2.78 2 Yes No 0 7 0 1
R:R:G152 R:R:P155 2.03 0 No No 4 7 2 1
R:R:L185 R:R:P184 1.64 0 No No 5 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength11.74
Average Nodes In Shell28.00
Average Hubs In Shell7.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9J5V A Lipid Lysophospholipid LPA1 Homo Sapiens CpY - Gi1/Beta1/Gamma2 2.86 2024-11-27  10.1038/s42003-024-07152-y

A 2D representation of the interactions of A1L in 9J5V
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Q125 5.26 2 Yes Yes 0 4 0 1
L:L:?1 R:R:I128 5.64 2 Yes Yes 0 6 0 1
L:L:?1 R:R:D129 9.97 2 Yes Yes 0 5 0 1
L:L:?1 R:R:M198 5.59 2 Yes Yes 0 3 0 1
L:L:?1 R:R:W210 8.37 2 Yes Yes 0 6 0 1
L:L:?1 R:R:L278 10.95 2 Yes No 0 6 0 1
L:L:?1 R:R:E293 4.49 2 Yes Yes 0 4 0 1
L:L:?1 R:R:L297 8.6 2 Yes No 0 6 0 1
R:R:K39 R:R:L290 5.64 2 No No 8 3 2 2
R:R:E293 R:R:K39 9.45 2 Yes No 4 8 1 2
R:R:A101 R:R:I128 3.25 0 No Yes 5 6 2 1
R:R:L297 R:R:Y102 10.55 0 No Yes 6 7 1 2
R:R:L105 R:R:R124 12.15 0 No Yes 6 6 2 2
R:R:I128 R:R:L105 5.71 0 Yes No 6 6 1 2
R:R:R124 R:R:W121 10 2 Yes Yes 6 9 2 2
R:R:Q125 R:R:W121 26.29 2 Yes Yes 4 9 1 2
R:R:W121 R:R:Y202 3.86 2 Yes Yes 9 4 2 2
R:R:Q125 R:R:R124 8.18 2 Yes Yes 4 6 1 2
R:R:Q125 R:R:Y202 7.89 2 Yes Yes 4 4 1 2
R:R:D129 R:R:G126 5.03 2 Yes No 5 6 1 2
R:R:I128 R:R:L132 2.85 0 Yes Yes 6 7 1 2
R:R:D129 R:R:Y202 9.2 2 Yes Yes 5 4 1 2
R:R:D129 R:R:Y206 9.2 2 Yes Yes 5 7 1 2
R:R:L132 R:R:W210 4.56 2 Yes Yes 7 6 2 1
R:R:L132 R:R:W271 5.69 2 Yes Yes 7 8 2 2
R:R:M178 R:R:T133 7.53 2 Yes No 5 6 2 2
R:R:T133 R:R:W210 7.28 2 No Yes 6 6 2 1
R:R:M178 R:R:Y206 5.99 2 Yes Yes 5 7 2 2
R:R:M178 R:R:W210 3.49 2 Yes Yes 5 6 2 1
R:R:L277 R:R:M198 2.83 0 No Yes 4 3 2 1
R:R:D281 R:R:M198 5.54 0 No Yes 4 3 2 1
R:R:L290 R:R:M198 2.83 2 No Yes 3 3 2 1
R:R:E293 R:R:M198 18.95 2 Yes Yes 4 3 1 1
R:R:Y202 R:R:Y206 11.91 2 Yes Yes 4 7 2 2
R:R:W210 R:R:W271 3.75 2 Yes Yes 6 8 1 2
R:R:E293 R:R:L290 3.98 2 Yes No 4 3 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.36
Average Nodes In Shell25.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.81
Average Number Of Links With An Hub4.93
Average Interaction Strength7.64
Average Nodes In Shell30.26
Average Hubs In Shell12.30
Average Links In Shell41.44
Average Links Mediated by Hubs In Shell35.89

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)