psnGPCR

Code	ADP
Name	Adenosine disphosphate
Synonyms	Adenosine disphosphate ADP
Identifier
Formula	C10 H15 N5 O10 P2
Molecular Weight	427.201
SMILES
PubChem	6022
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	5
Total Bonds	44
Total Aromatic Bonds	10
Networks	4

This ligand is also present in the following 4 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8WJX

Nucleotide

P2Y

P2Y1

Homo sapiens

ADP

chim(Gs-CtGq)/Beta1/Gamma2

3.2

2024-10-02

To be published

A 2D representation of the interactions of ADP in 8WJX
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L44	13.71	2	Yes	No	0	2	0	1
L:L:?1	R:R:Q50	8.53	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y110	6.83	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y111	4.78	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:T115	4.29	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:R128	3.54	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:R195	4.25	2	Yes	No	0	1	0	1
L:L:?1	R:R:T201	4.29	2	Yes	No	0	3	0	1
L:L:?1	R:R:D204	3.95	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:T205	4.29	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N283	8.8	2	Yes	No	0	4	0	1
L:L:?1	R:R:R287	10.62	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N299	4.8	2	Yes	No	0	2	0	1
L:L:?1	R:R:Y303	12.29	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:R310	8.49	2	Yes	Yes	0	5	0	1
R:R:C42	R:R:N299	7.87	2	No	No	8	2	2	1
R:R:C42	R:R:D300	3.11	2	No	No	8	2	2	2
R:R:L44	R:R:Y303	11.72	2	No	Yes	2	4	1	1
R:R:Q50	R:R:Y111	5.64	2	Yes	Yes	4	5	1	1
R:R:Q50	R:R:T115	5.67	2	Yes	Yes	4	4	1	1
R:R:Q50	R:R:Y303	13.53	2	Yes	Yes	4	4	1	1
R:R:Q307	R:R:Q50	14.08	2	Yes	Yes	5	4	2	1
R:R:Q50	R:R:R310	4.67	2	Yes	Yes	4	5	1	1
R:R:F51	R:R:T115	7.78	0	Yes	Yes	3	4	2	1
R:R:L54	R:R:Y58	4.69	2	Yes	Yes	6	7	2	2
R:R:L54	R:R:Y111	5.86	2	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	7.99	2	Yes	Yes	6	5	2	2
R:R:L54	R:R:R310	4.86	2	Yes	Yes	6	5	2	1
R:R:L107	R:R:Y58	3.52	2	Yes	Yes	7	7	2	2
R:R:Y111	R:R:Y58	4.96	2	Yes	Yes	5	7	1	2
R:R:L107	R:R:Y111	4.69	2	Yes	Yes	7	5	2	1
R:R:L107	R:R:R128	10.93	2	Yes	Yes	7	5	2	1
R:R:Y110	R:R:Y111	12.91	2	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	7.49	2	Yes	Yes	4	5	1	1
R:R:W117	R:R:Y110	5.79	2	Yes	Yes	8	5	2	1
R:R:R128	R:R:Y110	5.14	2	Yes	Yes	5	5	1	1
R:R:R128	R:R:Y111	4.12	2	Yes	Yes	5	5	1	1
R:R:R310	R:R:Y111	8.23	2	Yes	Yes	5	5	1	1
R:R:C202	R:R:W117	7.84	2	No	Yes	9	8	2	2
R:R:R128	R:R:S190	5.27	2	Yes	No	5	5	1	2
R:R:C202	R:R:R128	8.36	2	No	Yes	9	5	2	1
R:R:D204	R:R:R128	19.06	2	Yes	Yes	6	5	1	1
R:R:D204	R:R:H132	8.82	2	Yes	Yes	6	5	1	2
R:R:R195	R:R:T199	5.17	2	No	No	1	4	1	2
R:R:R195	R:R:T201	6.47	2	No	No	1	3	1	1
R:R:T201	R:R:Y203	9.99	2	No	No	3	4	1	2
R:R:D204	R:R:R310	3.57	2	Yes	Yes	6	5	1	1
R:R:T205	R:R:T206	3.14	2	Yes	Yes	5	5	1	2
R:R:T205	R:R:Y214	11.24	2	Yes	Yes	5	4	1	2
R:R:L284	R:R:T205	5.9	2	No	Yes	4	5	2	1
R:R:R287	R:R:T205	3.88	2	Yes	Yes	5	5	1	1
R:R:T206	R:R:Y214	8.74	2	Yes	Yes	5	4	2	2
R:R:D208	R:R:R287	4.76	0	No	Yes	3	5	2	1
R:R:L211	R:R:R287	7.29	0	No	Yes	4	5	2	1
R:R:L284	R:R:Y214	4.69	2	No	Yes	4	4	2	2
R:R:F276	R:R:Y306	4.13	2	Yes	Yes	7	4	2	2
R:R:F276	R:R:R310	5.34	2	Yes	Yes	7	5	2	1
R:R:N283	R:R:R287	4.82	2	No	Yes	4	5	1	1
R:R:N283	R:R:Y306	10.47	2	No	Yes	4	4	1	2
R:R:D300	R:R:N299	6.73	2	No	No	2	2	2	1
R:R:Q307	R:R:Y303	13.53	2	Yes	Yes	5	4	2	1
R:R:Q307	R:R:Y306	5.64	2	Yes	Yes	5	4	2	2
R:R:R310	R:R:Y306	19.55	2	Yes	Yes	5	4	1	2
R:R:Q307	R:R:R310	8.18	2	Yes	Yes	5	5	2	1
R:R:P55	R:R:Y111	2.78	0	No	Yes	6	5	2	1

Statistics	Value
Average Number Of Links	15.00
Average Number Of Links With An Hub	10.00
Average Interaction Strength	6.90
Average Nodes In Shell	37.00
Average Hubs In Shell	22.00
Average Links In Shell	65.00
Average Links Mediated by Hubs In Shell	59.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9JCL

Nucleotide

P2Y

P2Y1

Homo Sapiens

ADP

chim(Gs-CtGq)/Beta1/Gamma2

2.76

2025-09-10

To be published

A 2D representation of the interactions of ADP in 9JCL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L44	12.9	3	Yes	No	0	2	0	1
L:L:?1	R:R:Q50	17.83	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y110	9.56	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y111	5.46	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:R128	4.95	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:R195	6.37	3	Yes	Yes	0	1	0	1
L:L:?1	R:R:T201	4.29	3	Yes	No	0	3	0	1
L:L:?1	R:R:Y203	4.78	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:N283	8.8	3	Yes	No	0	4	0	1
L:L:?1	R:R:R287	14.15	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:N299	8.8	3	Yes	No	0	2	0	1
L:L:?1	R:R:Y303	11.61	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:R310	14.86	3	Yes	Yes	0	5	0	1
R:R:C42	R:R:N299	7.87	27	No	No	8	2	2	1
R:R:L44	R:R:Y303	9.38	3	No	Yes	2	4	1	1
R:R:T47	R:R:Y303	6.24	0	No	Yes	2	4	2	1
R:R:Q50	R:R:Y111	6.76	3	Yes	Yes	4	5	1	1
R:R:Q50	R:R:T115	7.09	3	Yes	No	4	4	1	2
R:R:Q50	R:R:Y303	11.27	3	Yes	Yes	4	4	1	1
R:R:Q307	R:R:Q50	11.52	3	Yes	Yes	5	4	2	1
R:R:Q50	R:R:R310	4.67	3	Yes	Yes	4	5	1	1
R:R:L54	R:R:Y58	9.38	3	Yes	Yes	6	7	2	2
R:R:L54	R:R:Y111	7.03	3	Yes	Yes	6	5	2	1
R:R:L54	R:R:Q307	6.65	3	Yes	Yes	6	5	2	2
R:R:L54	R:R:R310	4.86	3	Yes	Yes	6	5	2	1
R:R:Y111	R:R:Y58	6.95	3	Yes	Yes	5	7	1	2
R:R:L107	R:R:Y111	4.69	3	No	Yes	7	5	2	1
R:R:L107	R:R:R128	7.29	3	No	Yes	7	5	2	1
R:R:Y110	R:R:Y111	15.89	3	Yes	Yes	5	5	1	1
R:R:T115	R:R:Y110	7.49	0	No	Yes	4	5	2	1
R:R:W117	R:R:Y110	5.79	3	Yes	Yes	8	5	2	1
R:R:R128	R:R:Y110	5.14	3	Yes	Yes	5	5	1	1
R:R:R128	R:R:Y111	4.12	3	Yes	Yes	5	5	1	1
R:R:R310	R:R:Y111	10.29	3	Yes	Yes	5	5	1	1
R:R:C202	R:R:W117	14.37	3	No	Yes	9	8	2	2
R:R:R128	R:R:S190	5.27	3	Yes	No	5	5	1	2
R:R:C202	R:R:R128	5.57	3	No	Yes	9	5	2	1
R:R:D204	R:R:R128	21.44	0	No	Yes	6	5	2	1
R:R:R195	R:R:T201	3.88	3	Yes	No	1	3	1	1
R:R:R195	R:R:Y203	5.14	3	Yes	Yes	1	4	1	1
R:R:T201	R:R:Y203	9.99	3	No	Yes	3	4	1	1
R:R:S207	R:R:Y203	3.82	0	No	Yes	5	4	2	1
R:R:R287	R:R:T205	5.17	0	Yes	No	5	5	1	2
R:R:L211	R:R:R287	6.07	0	No	Yes	4	5	2	1
R:R:N283	R:R:Y306	17.44	0	No	Yes	4	4	1	2
R:R:Q307	R:R:Y303	11.27	3	Yes	Yes	5	4	2	1
R:R:Q307	R:R:Y306	5.64	3	Yes	Yes	5	4	2	2
R:R:R310	R:R:Y306	23.66	3	Yes	Yes	5	4	1	2
R:R:Q307	R:R:R310	11.68	3	Yes	Yes	5	5	2	1
R:R:N197	R:R:R195	3.62	0	No	Yes	4	1	2	1
R:R:D208	R:R:R287	3.57	0	No	Yes	3	5	2	1
L:L:?1	R:R:Q291	3.1	3	Yes	No	0	2	0	1
R:R:G193	R:R:Y203	2.9	0	No	Yes	2	4	2	1
R:R:P55	R:R:Y111	2.78	0	No	Yes	6	5	2	1

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	9.00
Average Interaction Strength	9.10
Average Nodes In Shell	34.00
Average Hubs In Shell	15.00
Average Links In Shell	54.00
Average Links Mediated by Hubs In Shell	53.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	8.50
Average Interaction Strength	8.47
Average Nodes In Shell	32.25
Average Hubs In Shell	16.50
Average Links In Shell	53.00
Average Links Mediated by Hubs In Shell	50.50

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)