CodeAKG
NameOxogluric acid
Synonyms2-oxoglutaric acid
Identifier
FormulaC5 H6 O5
Molecular Weight146.098
SMILES
PubChem51
Formal Charge0
Total Atoms16
Total Chiral Atoms0
Total Bonds15
Total Aromatic Bonds0
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YYW A Alicarboxylic acid Oxoglutarate Oxoglutarate Homo Sapiens Alpha-ketoglutarate Alpha-ketoglutarate chim(Gi1-CtGq)/Beta1/Gamma2 3.19 2025-04-09 To be published

A 2D representation of the interactions of AKG in 8YYW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D26 R:R:N28 4.04 2 No Yes 4 3 1 2
R:R:D26 R:R:H281 7.56 2 No Yes 4 4 1 1
R:R:D26 W:W:?1 4.48 2 No Yes 4 0 1 0
R:R:H281 R:R:N28 3.83 2 Yes Yes 4 3 1 2
R:R:I285 R:R:N28 2.83 2 Yes Yes 5 3 2 2
R:R:K32 R:R:L36 2.82 2 Yes Yes 3 6 1 2
R:R:K32 R:R:Y93 5.97 2 Yes Yes 3 5 1 2
R:R:E97 R:R:K32 6.75 2 Yes Yes 4 3 1 1
R:R:I285 R:R:K32 5.82 2 Yes Yes 5 3 2 1
R:R:K32 W:W:?1 11.63 2 Yes Yes 3 0 1 0
R:R:L36 R:R:Y93 5.86 2 Yes Yes 6 5 2 2
R:R:I285 R:R:L36 2.85 2 Yes Yes 5 6 2 2
R:R:E97 R:R:Y92 14.59 2 Yes No 4 5 1 1
R:R:W99 R:R:Y92 10.61 2 Yes No 9 5 2 1
R:R:Y92 W:W:?1 8.7 2 No Yes 5 0 1 0
R:R:R110 R:R:Y93 3.09 0 Yes Yes 5 5 1 2
R:R:E97 R:R:R180 6.98 2 Yes No 4 2 1 2
R:R:E97 W:W:?1 13.11 2 Yes Yes 4 0 1 0
R:R:C183 R:R:W99 3.92 2 Yes Yes 9 9 2 2
R:R:C183 R:R:R110 4.18 2 Yes Yes 9 5 2 1
R:R:R110 W:W:?1 3 0 Yes Yes 5 0 1 0
L:L:?1 R:R:R110 10.02 2 Yes Yes 0 5 2 1
R:R:L184 R:R:T173 4.42 0 No No 4 4 1 2
R:R:A182 W:W:?1 3.9 0 No Yes 3 0 1 0
R:R:L184 W:W:?1 5.71 0 No Yes 4 0 1 0
R:R:D185 R:R:T187 2.89 2 Yes Yes 5 4 1 2
R:R:D185 R:R:S188 4.42 2 Yes No 5 5 1 2
R:R:D185 W:W:?1 6.71 2 Yes Yes 5 0 1 0
L:L:?1 R:R:D185 7.83 2 Yes Yes 0 5 2 1
R:R:R264 R:R:T187 5.17 2 Yes Yes 5 4 2 2
L:L:?1 R:R:T187 3.65 2 Yes Yes 0 4 2 2
R:R:H281 R:R:R264 18.05 2 Yes Yes 4 5 1 2
R:R:H281 R:R:I285 6.63 2 Yes Yes 4 5 1 2
R:R:H281 W:W:?1 8.48 2 Yes Yes 4 0 1 0
R:R:L184 R:R:T175 1.47 0 No No 4 3 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.30
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of AKG in 8YYW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F113 R:R:Y82 10.32 2 Yes No 6 7 1 2
R:R:R110 R:R:Y93 3.09 0 Yes Yes 5 5 1 2
R:R:R288 R:R:Y93 4.12 2 No Yes 6 5 1 2
R:R:C183 R:R:R110 4.18 2 Yes Yes 9 5 2 1
R:R:R110 W:W:?1 3 0 Yes Yes 5 0 1 2
L:L:?1 R:R:R110 10.02 2 Yes Yes 0 5 0 1
R:R:F113 R:R:H114 7.92 2 Yes No 6 6 1 1
R:R:F113 R:R:L117 3.65 2 Yes No 6 8 1 2
L:L:?1 R:R:F113 13.05 2 Yes Yes 0 6 0 1
R:R:H114 R:R:M168 14.44 2 No Yes 6 4 1 2
L:L:?1 R:R:H114 12.72 2 Yes No 0 6 0 1
R:R:L117 R:R:Y118 3.52 0 No Yes 8 7 2 2
R:R:H258 R:R:Y118 9.8 2 Yes Yes 8 7 2 2
R:R:R261 R:R:Y118 4.12 2 Yes Yes 5 7 1 2
R:R:L186 R:R:M168 7.07 0 No Yes 3 4 1 2
R:R:D185 R:R:T187 2.89 2 Yes Yes 5 4 1 1
R:R:D185 R:R:S188 4.42 2 Yes No 5 5 1 2
R:R:D185 W:W:?1 6.71 2 Yes Yes 5 0 1 2
L:L:?1 R:R:D185 7.83 2 Yes Yes 0 5 0 1
R:R:I195 R:R:L186 2.85 0 Yes No 4 3 2 1
L:L:?1 R:R:L186 4.56 2 Yes No 0 3 0 1
R:R:R264 R:R:T187 5.17 2 Yes Yes 5 4 2 1
R:R:I265 R:R:T187 6.08 0 No Yes 5 4 2 1
R:R:T187 R:R:Y284 4.99 2 Yes Yes 4 5 1 1
L:L:?1 R:R:T187 3.65 2 Yes Yes 0 4 0 1
R:R:I195 R:R:I265 2.94 0 Yes No 4 5 2 2
R:R:N199 R:R:R261 4.82 0 Yes Yes 6 5 2 1
R:R:I265 R:R:N199 8.5 0 No Yes 5 6 2 2
R:R:F257 R:R:H258 4.53 2 Yes Yes 7 8 1 2
R:R:F257 R:R:R261 8.55 2 Yes Yes 7 5 1 1
R:R:F257 R:R:Y284 9.28 2 Yes Yes 7 5 1 1
R:R:F257 R:R:R288 3.21 2 Yes No 7 6 1 1
L:L:?1 R:R:F257 3.01 2 Yes Yes 0 7 0 1
R:R:H258 R:R:R261 3.39 2 Yes Yes 8 5 2 1
R:R:R261 R:R:Y284 10.29 2 Yes Yes 5 5 1 1
L:L:?1 R:R:R261 9.01 2 Yes Yes 0 5 0 1
R:R:S287 R:R:Y284 5.09 0 No Yes 7 5 2 1
L:L:?1 R:R:Y284 12.57 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R288 16.03 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.24
Average Nodes In Shell25.00
Average Hubs In Shell17.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.75
Average Interaction Strength8.58
Average Nodes In Shell22.50
Average Hubs In Shell13.00
Average Links In Shell31.50
Average Links Mediated by Hubs In Shell29.75

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)