Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5VBL | A | Peptide | Apelin | Apelin | Homo sapiens | Apelin Mimetic Peptide Agonist | - | - | 2.6 | 2017-05-31 | 10.1016/j.str.2017.04.008 |
![](/psngpcr/ligands/ALC/ALC_5VBL_L_L_9.png)
A 2D representation of the interactions of ALC in 5VBL colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?9 | R:R:E20 | 11.33 | 0 | Yes | No | 0 | 5 | 0 | 1 | R:R:D23 | R:R:T176 | 5.78 | 1 | No | No | 5 | 3 | 2 | 2 | L:L:?8 | R:R:D23 | 8.49 | 0 | No | No | 0 | 5 | 1 | 2 | L:L:E10 | R:R:E174 | 13.95 | 1 | Yes | No | 0 | 2 | 1 | 2 | L:L:K13 | R:R:E174 | 5.4 | 1 | Yes | No | 0 | 2 | 2 | 2 | L:L:?8 | R:R:N175 | 10.74 | 0 | No | No | 0 | 2 | 1 | 2 | L:L:E10 | R:R:T176 | 4.23 | 1 | Yes | No | 0 | 3 | 1 | 2 | L:L:?8 | L:L:?9 | 18.52 | 0 | No | Yes | 0 | 0 | 1 | 0 | L:L:?9 | L:L:E10 | 4.53 | 0 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:E10 | L:L:K13 | 21.6 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:P7 | R:R:T22 | 3.5 | 0 | No | No | 0 | 4 | 2 | 1 | L:L:?9 | R:R:T22 | 2.52 | 0 | Yes | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 9.23 | Average Nodes In Shell | 11.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 12.00 | Average Links Mediated by Hubs In Shell | 8.00 |
| ![](/psngpcr/ligands/ALC/ALC_5VBL_L_L_9_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALC/ALC_5VBL_L_L_9_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7Y65 | A | Peptide | Complement peptide | C5A1 | Homo Sapiens | C5a peptide | - | Gi1/Beta1/Gamma2 | 3.2 | 2023-03-01 | 10.1038/s41422-023-00779-2 |
![](/psngpcr/ligands/ALC/ALC_7Y65_L_L_5.png)
A 2D representation of the interactions of ALC in 7Y65 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | L:L:?5 | 25.28 | 2 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?4 | L:L:?6 | 2.06 | 2 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?4 | R:R:L92 | 6.43 | 2 | Yes | No | 0 | 6 | 1 | 1 | L:L:?4 | R:R:P113 | 3.05 | 2 | Yes | No | 0 | 6 | 1 | 2 | L:L:?4 | R:R:R175 | 5.64 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?5 | L:L:?6 | 31.23 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | L:L:?5 | R:R:L92 | 2.37 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?5 | R:R:I116 | 6.1 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?5 | R:R:L117 | 2.37 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?5 | R:R:V286 | 3.82 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?6 | R:R:V190 | 3.57 | 2 | Yes | No | 0 | 5 | 1 | 2 | L:L:?6 | R:R:Y258 | 15.93 | 2 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?6 | R:R:D282 | 10.85 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:?6 | R:R:V286 | 2.38 | 2 | Yes | Yes | 0 | 5 | 1 | 1 | R:R:F44 | R:R:L89 | 7.31 | 2 | Yes | No | 7 | 7 | 2 | 2 | R:R:F44 | R:R:V286 | 2.62 | 2 | Yes | Yes | 7 | 5 | 2 | 1 | R:R:L89 | R:R:L92 | 4.15 | 0 | No | No | 7 | 6 | 2 | 1 | R:R:P113 | R:R:R175 | 8.65 | 2 | No | Yes | 6 | 5 | 2 | 2 | R:R:L117 | R:R:Y121 | 2.34 | 0 | No | No | 4 | 7 | 1 | 2 | R:R:R175 | R:R:V190 | 2.62 | 2 | Yes | No | 5 | 5 | 2 | 2 | R:R:V286 | R:R:Y258 | 5.05 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | R:R:A88 | R:R:I116 | 1.62 | 0 | No | No | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 6.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 11.86 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/ALC/ALC_7Y65_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALC/ALC_7Y65_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8HPT | A | Peptide | Complement peptide | C5a1 | Mus Musculus | C5a anaphylatoxin C-terminal peptide | - | Go/Beta1/Gamma2 | 3.39 | 2023-10-18 | 10.1016/j.cell.2023.09.020 |
![](/psngpcr/ligands/ALC/ALC_8HPT_L_L_5.png)
A 2D representation of the interactions of ALC in 8HPT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L92 | R:R:Y291 | 3.52 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?5 | R:R:L92 | 3.55 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:I110 | R:R:R175 | 3.76 | 0 | No | Yes | 7 | 4 | 2 | 1 | R:R:P113 | R:R:R175 | 8.65 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:I116 | R:R:Y291 | 3.63 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?5 | R:R:I116 | 4.88 | 4 | Yes | No | 0 | 6 | 0 | 1 | R:R:L117 | R:R:Y121 | 8.21 | 0 | No | No | 4 | 7 | 1 | 2 | L:L:?5 | R:R:L117 | 4.74 | 4 | Yes | No | 0 | 4 | 0 | 1 | R:R:R207 | R:R:Y121 | 10.29 | 4 | Yes | No | 5 | 7 | 2 | 2 | L:L:?4 | R:R:R175 | 5.64 | 4 | Yes | Yes | 0 | 4 | 1 | 1 | L:L:?5 | R:R:R175 | 3.12 | 4 | Yes | Yes | 0 | 4 | 0 | 1 | L:L:?4 | R:R:Y178 | 8.71 | 4 | Yes | No | 0 | 1 | 1 | 2 | L:L:?6 | R:R:R207 | 2.91 | 4 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:W256 | R:R:Y259 | 6.75 | 4 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:Q260 | R:R:Y259 | 3.38 | 0 | No | Yes | 8 | 7 | 2 | 1 | L:L:?5 | R:R:Y259 | 4.01 | 4 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?6 | R:R:Y259 | 17.81 | 4 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:?6 | R:R:T262 | 4.71 | 4 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?6 | R:R:G263 | 5.47 | 4 | Yes | No | 0 | 6 | 1 | 2 | L:L:?6 | R:R:N283 | 14.27 | 4 | Yes | No | 0 | 4 | 1 | 2 | L:L:?5 | R:R:V287 | 6.37 | 4 | Yes | No | 0 | 5 | 0 | 1 | L:L:?4 | L:L:P3 | 4.57 | 4 | Yes | No | 0 | 0 | 1 | 2 | L:L:?4 | L:L:?5 | 25.28 | 4 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?5 | L:L:?6 | 28.39 | 4 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:R175 | R:R:S171 | 2.64 | 4 | Yes | No | 4 | 5 | 1 | 2 | L:L:?4 | R:R:N100 | 2.55 | 4 | Yes | No | 0 | 3 | 1 | 2 | R:R:A88 | R:R:I116 | 1.62 | 0 | No | No | 7 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.04 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 27.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/ALC/ALC_8HPT_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ALC/ALC_8HPT_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|