psnGPCR

Code	ALC
Name	3-Cyclohexyl-L-alanine
Synonyms	β-Cyclohexyl-alanine beta-Cyclohexyl-L-alanine 3-Cyclohexyl-L-alanine beta-Cyclohexyl-alanine
Identifier	(2S)-2-amino-3-cyclohexyl-propanoic acid
Formula	C9 H17 N O2
Molecular Weight	171.237
SMILES	C1CCC(CC1)C[C@@H](C(=O)O)N
PubChem	712421
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	29
Total Aromatic Bonds	0
Networks	3

This ligand is also present in the following 3 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

5VBL

Peptide

Apelin

Homo sapiens

Apelin Mimetic Peptide Agonist

2.6

2017-05-31

10.1016/j.str.2017.04.008

A 2D representation of the interactions of ALC in 5VBL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?9	R:R:E20	11.33	0	Yes	No	0	5	0	1
R:R:D23	R:R:T176	5.78	1	No	No	5	3	2	2
L:L:?8	R:R:D23	8.49	0	No	No	0	5	1	2
L:L:E10	R:R:E174	13.95	1	Yes	No	0	2	1	2
L:L:K13	R:R:E174	5.4	1	Yes	No	0	2	2	2
L:L:?8	R:R:N175	10.74	0	No	No	0	2	1	2
L:L:E10	R:R:T176	4.23	1	Yes	No	0	3	1	2
L:L:?8	L:L:?9	18.52	0	No	Yes	0	0	1	0
L:L:?9	L:L:E10	4.53	0	Yes	Yes	0	0	0	1
L:L:E10	L:L:K13	21.6	1	Yes	Yes	0	0	1	2
L:L:P7	R:R:T22	3.5	0	No	No	0	4	2	1
L:L:?9	R:R:T22	2.52	0	Yes	No	0	4	0	1

Statistics	Value
Average Number Of Links	4.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	9.23
Average Nodes In Shell	11.00
Average Hubs In Shell	3.00
Average Links In Shell	12.00
Average Links Mediated by Hubs In Shell	8.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7Y65

Peptide

Complement peptide

C5A1

Homo Sapiens

C5a peptide

Gi1/Beta1/Gamma2

3.2

2023-03-01

10.1038/s41422-023-00779-2

A 2D representation of the interactions of ALC in 7Y65
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?4	L:L:?5	25.28	2	Yes	Yes	0	0	1	0
L:L:?4	L:L:?6	2.06	2	Yes	Yes	0	0	1	1
L:L:?4	R:R:L92	6.43	2	Yes	No	0	6	1	1
L:L:?4	R:R:P113	3.05	2	Yes	No	0	6	1	2
L:L:?4	R:R:R175	5.64	2	Yes	Yes	0	5	1	2
L:L:?5	L:L:?6	31.23	2	Yes	Yes	0	0	0	1
L:L:?5	R:R:L92	2.37	2	Yes	No	0	6	0	1
L:L:?5	R:R:I116	6.1	2	Yes	No	0	6	0	1
L:L:?5	R:R:L117	2.37	2	Yes	No	0	4	0	1
L:L:?5	R:R:V286	3.82	2	Yes	Yes	0	5	0	1
L:L:?6	R:R:V190	3.57	2	Yes	No	0	5	1	2
L:L:?6	R:R:Y258	15.93	2	Yes	Yes	0	7	1	2
L:L:?6	R:R:D282	10.85	2	Yes	No	0	4	1	2
L:L:?6	R:R:V286	2.38	2	Yes	Yes	0	5	1	1
R:R:F44	R:R:L89	7.31	2	Yes	No	7	7	2	2
R:R:F44	R:R:V286	2.62	2	Yes	Yes	7	5	2	1
R:R:L89	R:R:L92	4.15	0	No	No	7	6	2	1
R:R:P113	R:R:R175	8.65	2	No	Yes	6	5	2	2
R:R:L117	R:R:Y121	2.34	0	No	No	4	7	1	2
R:R:R175	R:R:V190	2.62	2	Yes	No	5	5	2	2
R:R:V286	R:R:Y258	5.05	2	Yes	Yes	5	7	1	2
R:R:A88	R:R:I116	1.62	0	No	No	6	6	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	11.86
Average Nodes In Shell	16.00
Average Hubs In Shell	7.00
Average Links In Shell	22.00
Average Links Mediated by Hubs In Shell	19.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8HPT

Peptide

Complement peptide

C5a1

Mus Musculus

C5a anaphylatoxin C-terminal peptide

Go/Beta1/Gamma2

3.39

2023-10-18

10.1016/j.cell.2023.09.020

A 2D representation of the interactions of ALC in 8HPT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L92	R:R:Y291	3.52	0	No	Yes	6	7	1	2
L:L:?5	R:R:L92	3.55	4	Yes	No	0	6	0	1
R:R:I110	R:R:R175	3.76	0	No	Yes	7	4	2	1
R:R:P113	R:R:R175	8.65	0	No	Yes	5	4	2	1
R:R:I116	R:R:Y291	3.63	0	No	Yes	6	7	1	2
L:L:?5	R:R:I116	4.88	4	Yes	No	0	6	0	1
R:R:L117	R:R:Y121	8.21	0	No	No	4	7	1	2
L:L:?5	R:R:L117	4.74	4	Yes	No	0	4	0	1
R:R:R207	R:R:Y121	10.29	4	Yes	No	5	7	2	2
L:L:?4	R:R:R175	5.64	4	Yes	Yes	0	4	1	1
L:L:?5	R:R:R175	3.12	4	Yes	Yes	0	4	0	1
L:L:?4	R:R:Y178	8.71	4	Yes	No	0	1	1	2
L:L:?6	R:R:R207	2.91	4	Yes	Yes	0	5	1	2
R:R:W256	R:R:Y259	6.75	4	Yes	Yes	8	7	2	1
R:R:Q260	R:R:Y259	3.38	0	No	Yes	8	7	2	1
L:L:?5	R:R:Y259	4.01	4	Yes	Yes	0	7	0	1
L:L:?6	R:R:Y259	17.81	4	Yes	Yes	0	7	1	1
L:L:?6	R:R:T262	4.71	4	Yes	Yes	0	5	1	2
L:L:?6	R:R:G263	5.47	4	Yes	No	0	6	1	2
L:L:?6	R:R:N283	14.27	4	Yes	No	0	4	1	2
L:L:?5	R:R:V287	6.37	4	Yes	No	0	5	0	1
L:L:?4	L:L:P3	4.57	4	Yes	No	0	0	1	2
L:L:?4	L:L:?5	25.28	4	Yes	Yes	0	0	1	0
L:L:?5	L:L:?6	28.39	4	Yes	Yes	0	0	0	1
R:R:R175	R:R:S171	2.64	4	Yes	No	4	5	1	2
L:L:?4	R:R:N100	2.55	4	Yes	No	0	3	1	2
R:R:A88	R:R:I116	1.62	0	No	No	7	6	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.04
Average Nodes In Shell	24.00
Average Hubs In Shell	9.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	25.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	2.67
Average Interaction Strength	10.38
Average Nodes In Shell	17.00
Average Hubs In Shell	6.33
Average Links In Shell	20.33
Average Links Mediated by Hubs In Shell	17.33

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)