psnGPCR

Code	B40
Name	Metamfetamine
Synonyms	Dextromethamphetamine
Identifier
Formula	C10 H15 N
Molecular Weight	149.233
SMILES
PubChem	10836
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8W87

Amine

Trace Amine

TA1

Homo Sapiens

METH

chim(NtGi1L-Gs)/Beta1/Gamma2

2.8

2023-11-22

doi.org/10.1038/s41586-023-06775-1

A 2D representation of the interactions of B40 in 8W87
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	9.95	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:I104	15.7	2	Yes	No	0	4	0	1
L:L:?1	R:R:S107	11.01	2	Yes	No	0	6	0	1
L:L:?1	R:R:F186	4.47	2	Yes	Yes	0	1	0	1
L:L:?1	R:R:T194	4.05	2	Yes	No	0	5	0	1
L:L:?1	R:R:S198	5.5	2	Yes	No	0	6	0	1
L:L:?1	R:R:W264	4.18	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:F267	13.4	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	7.81	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:I290	5.23	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y294	5.37	2	Yes	Yes	0	7	0	1
R:R:H99	R:R:V76	9.69	2	Yes	Yes	5	7	2	2
R:R:D103	R:R:V76	8.76	2	Yes	Yes	6	7	1	2
R:R:V76	R:R:Y294	3.79	2	Yes	Yes	7	7	2	1
R:R:M77	R:R:Y294	9.58	0	Yes	Yes	7	7	2	1
R:R:H99	R:R:S80	4.18	2	Yes	No	5	6	2	2
R:R:S80	R:R:Y294	7.63	0	No	Yes	6	7	2	1
R:R:D103	R:R:H99	3.78	2	Yes	Yes	6	5	1	2
R:R:D103	R:R:Y294	6.9	2	Yes	Yes	6	7	1	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:S107	R:R:W264	4.94	2	No	Yes	6	8	1	1
R:R:S108	R:R:S198	6.52	0	No	No	5	6	2	1
R:R:I111	R:R:W264	10.57	0	No	Yes	8	8	2	1
R:R:F154	R:R:M158	6.22	0	No	No	4	5	2	2
R:R:F154	R:R:T194	5.19	0	No	No	4	5	2	1
R:R:F186	R:R:M158	3.73	2	Yes	No	1	5	1	2
R:R:F186	R:R:V184	5.24	2	Yes	No	1	4	1	2
R:R:F186	R:R:S190	6.61	2	Yes	No	1	6	1	2
R:R:F186	R:R:T194	11.67	2	Yes	No	1	5	1	1
R:R:F195	R:R:F199	5.36	2	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	4.29	2	Yes	Yes	5	7	2	1
R:R:F199	R:R:F260	5.36	2	Yes	Yes	8	9	2	2
R:R:F199	R:R:F268	22.51	2	Yes	Yes	8	7	2	1
R:R:F260	R:R:W264	4.01	0	Yes	Yes	9	8	2	1
R:R:F267	R:R:W264	5.01	2	Yes	Yes	5	8	1	1
R:R:F268	R:R:W264	9.02	2	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	8.44	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	9.04	0	No	Yes	9	8	2	1
R:R:F267	R:R:F268	6.43	2	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	6.49	2	Yes	No	5	5	1	2
R:R:F267	R:R:L289	3.65	2	Yes	No	5	5	1	2
R:R:I290	R:R:W291	5.87	2	No	Yes	5	4	1	2
R:R:I290	R:R:Y294	4.84	2	No	Yes	5	7	1	1
R:R:W291	R:R:Y294	9.65	2	Yes	Yes	4	7	2	1
R:R:F186	R:R:G191	3.01	2	Yes	No	1	4	1	2
R:R:I104	R:R:I159	2.94	0	No	Yes	4	6	1	2

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	7.88
Average Nodes In Shell	33.00
Average Hubs In Shell	15.00
Average Links In Shell	46.00
Average Links Mediated by Hubs In Shell	42.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9JKQ

Amine

Trace Amine

TA1

Homo Sapiens

METH

Gs/Beta1/Gamma2

2.66

2024-10-16

doi.org/10.1021/acs.jmedchem.4c01961

A 2D representation of the interactions of B40 in 9JKQ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D103	R:R:V76	7.3	2	Yes	No	6	7	1	2
R:R:I159	R:R:T100	3.04	0	Yes	No	6	4	2	2
R:R:T100	R:R:V184	3.17	0	No	No	4	4	2	1
R:R:D103	R:R:S107	4.42	2	Yes	No	6	6	1	1
R:R:D103	R:R:Y294	10.34	2	Yes	Yes	6	7	1	2
L:L:?1	R:R:D103	15.15	2	Yes	Yes	0	6	0	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:I104	R:R:I159	2.94	0	No	Yes	4	6	1	2
L:L:?1	R:R:I104	15.93	2	Yes	No	0	4	0	1
R:R:S107	R:R:W264	4.94	2	No	Yes	6	8	1	2
L:L:?1	R:R:S107	6.98	2	Yes	No	0	6	0	1
R:R:P151	R:R:S108	3.56	0	No	No	8	5	2	1
R:R:S108	R:R:S198	6.52	2	No	No	5	6	1	1
L:L:?1	R:R:S108	2.79	2	Yes	No	0	5	0	1
R:R:F186	R:R:V184	3.93	2	Yes	No	1	4	1	1
L:L:?1	R:R:V184	2.77	2	Yes	No	0	4	0	1
R:R:F186	R:R:S190	7.93	2	Yes	Yes	1	6	1	2
R:R:F186	R:R:G191	3.01	2	Yes	No	1	4	1	2
R:R:F186	R:R:T194	6.49	2	Yes	No	1	5	1	2
L:L:?1	R:R:F186	3.4	2	Yes	Yes	0	1	0	1
R:R:G191	R:R:S190	3.71	2	No	Yes	4	6	2	2
R:R:F195	R:R:F199	6.43	2	Yes	No	5	8	2	2
R:R:F195	R:R:F268	6.43	2	Yes	Yes	5	7	2	1
R:R:S198	R:R:T197	3.2	2	No	No	6	4	1	2
L:L:?1	R:R:S198	2.79	2	Yes	No	0	6	0	1
R:R:F199	R:R:F268	20.36	2	No	Yes	8	7	2	1
R:R:F268	R:R:W264	5.01	2	Yes	Yes	7	8	1	2
R:R:F267	R:R:F268	6.43	2	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	7.78	2	Yes	No	5	5	1	2
R:R:F267	R:R:L289	3.65	2	Yes	No	5	5	1	2
R:R:F267	R:R:I290	3.77	2	Yes	Yes	5	5	1	1
L:L:?1	R:R:F267	13.59	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	6.8	2	Yes	Yes	0	7	0	1
R:R:I290	R:R:N286	4.25	2	Yes	No	5	4	1	2
R:R:I290	R:R:Y294	6.04	2	Yes	Yes	5	7	1	2
L:L:?1	R:R:I290	3.98	2	Yes	Yes	0	5	0	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.42
Average Nodes In Shell	27.00
Average Hubs In Shell	11.00
Average Links In Shell	36.00
Average Links Mediated by Hubs In Shell	31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9U9V

Amine

Adrenergic

Beta2

Homo Sapiens

METH

Gs/Beta1/Gamma2

2.85

2025-09-03

To be published

A 2D representation of the interactions of B40 in 9U9V
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D113	12.62	2	Yes	No	0	7	0	1
L:L:?1	R:R:V114	4.16	2	Yes	No	0	5	0	1
L:L:?1	R:R:V117	11.09	2	Yes	No	0	6	0	1
L:L:?1	R:R:F193	4.53	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:F289	9.06	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:N293	6.39	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:N312	8.94	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y316	5.45	2	Yes	Yes	0	6	0	1
R:R:M82	R:R:V117	3.04	0	No	No	7	6	2	1
R:R:D113	R:R:V86	11.69	2	No	No	7	7	1	2
R:R:V86	R:R:Y316	3.79	2	No	Yes	7	6	2	1
R:R:F193	R:R:T110	3.89	0	Yes	No	4	4	1	2
R:R:D113	R:R:Y316	9.2	2	No	Yes	7	6	1	1
R:R:S165	R:R:V114	3.23	0	Yes	No	7	5	2	1
R:R:V117	R:R:W286	4.9	0	No	Yes	6	8	1	2
R:R:F193	R:R:Y174	7.22	0	Yes	Yes	4	5	1	2
R:R:F193	R:R:T195	7.78	0	Yes	No	4	3	1	2
R:R:F290	R:R:S204	5.28	2	Yes	No	7	5	2	2
R:R:N293	R:R:S204	7.45	2	Yes	No	5	5	1	2
R:R:F289	R:R:W286	7.02	2	Yes	Yes	6	8	1	2
R:R:F290	R:R:W286	4.01	2	Yes	Yes	7	8	2	2
R:R:F289	R:R:F290	7.5	2	Yes	Yes	6	7	1	2
R:R:F289	R:R:N293	3.62	2	Yes	Yes	6	5	1	1
R:R:F289	R:R:Y308	8.25	2	Yes	Yes	6	5	1	2
R:R:F289	R:R:N312	9.67	2	Yes	No	6	5	1	1
R:R:N293	R:R:Y308	3.49	2	Yes	Yes	5	5	1	2
R:R:N312	R:R:Y316	9.3	2	No	Yes	5	6	1	1
R:R:W313	R:R:Y316	6.75	2	Yes	Yes	5	6	2	1

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	7.78
Average Nodes In Shell	20.00
Average Hubs In Shell	11.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	26.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	9.67
Average Number Of Links With An Hub	5.00
Average Interaction Strength	7.71
Average Nodes In Shell	26.67
Average Hubs In Shell	12.33
Average Links In Shell	36.67
Average Links Mediated by Hubs In Shell	33.17

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)