psnGPCR

Code	DAR
Name	D-arginine
Synonyms	(2R)-2-amino-5-(carbamimidamido)pentanoic acid
Identifier	[amino-[[(4R)-4-amino-5-hydroxy-5-oxo-pentyl]amino]methylidene]azanium
Formula	C6 H15 N4 O2
Molecular Weight	175.209
SMILES	C(C[C@H](C(=O)O)N)CNC(=[NH2+])N
PubChem	59667378
Formal Charge	1
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	0
Networks	5

This ligand is also present in the following 5 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PT2

Peptide

Opioid

DOP

Homo sapiens

KGCHM07

2.8

2019-12-11

10.1126/sciadv.aax9115

A 2D representation of the interactions of DAR in 6PT2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I304	R:R:Y56	7.25	1	Yes	Yes	5	7	1	2
R:R:D128	R:R:Y308	6.9	1	No	Yes	5	7	2	2
L:L:?1	R:R:D128	10.47	1	Yes	No	0	5	1	2
L:L:?1	R:R:Y129	10.86	1	Yes	No	0	5	1	2
R:R:M132	R:R:V217	3.04	1	Yes	No	8	5	2	2
R:R:M132	R:R:W274	3.49	1	Yes	Yes	8	8	2	2
L:L:?1	R:R:M132	10.91	1	Yes	Yes	0	8	1	2
R:R:D210	R:R:K214	11.06	0	No	Yes	4	5	2	1
R:R:K214	R:R:V281	4.55	1	Yes	Yes	5	6	1	1
R:R:K214	R:R:W284	3.48	1	Yes	No	5	4	1	1
R:R:K214	R:R:T285	4.5	1	Yes	No	5	4	1	2
L:L:?2	R:R:K214	3.38	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V217	8.05	1	Yes	No	0	5	1	2
R:R:H278	R:R:W274	4.23	1	Yes	Yes	7	8	2	2
L:L:?1	R:R:W274	3.52	1	Yes	Yes	0	8	1	2
R:R:I277	R:R:V281	3.07	1	Yes	Yes	5	6	2	1
R:R:I277	R:R:I304	2.94	1	Yes	Yes	5	5	2	1
L:L:?1	R:R:I277	5.51	1	Yes	Yes	0	5	1	2
L:L:?1	R:R:H278	5.95	1	Yes	Yes	0	7	1	2
R:R:F280	R:R:L300	7.31	1	Yes	No	5	5	2	2
L:L:?5	R:R:F280	8.89	1	Yes	Yes	0	5	1	2
L:L:?2	R:R:V281	3.57	1	Yes	Yes	0	6	0	1
L:L:?5	R:R:V281	6.92	1	Yes	Yes	0	6	1	1
L:L:?2	R:R:W284	3.64	1	Yes	No	0	4	0	1
L:L:?5	R:R:W284	49.14	1	Yes	No	0	4	1	1
L:L:?5	R:R:I289	5.68	1	Yes	No	0	1	1	2
L:L:?5	R:R:R291	10.48	1	Yes	No	0	1	1	2
R:R:I304	R:R:L300	5.71	1	Yes	No	5	5	1	2
L:L:?5	R:R:L300	16.54	1	Yes	No	0	5	1	2
L:L:?1	R:R:I304	3.3	1	Yes	Yes	0	5	1	1
L:L:?2	R:R:I304	3.42	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y308	4.52	1	Yes	Yes	0	7	1	2
L:L:?1	L:L:?2	23.05	1	Yes	Yes	0	0	1	0
L:L:?2	L:L:?4	17.2	1	Yes	No	0	0	0	1
L:L:?2	L:L:?5	12.49	1	Yes	Yes	0	0	0	1
L:L:?4	L:L:F3	10.1	1	No	Yes	0	0	1	2
L:L:?4	L:L:?5	15.23	1	No	Yes	0	0	1	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	9.54
Average Nodes In Shell	24.00
Average Hubs In Shell	14.00
Average Links In Shell	37.00
Average Links Mediated by Hubs In Shell	37.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7M3G

Ion

Calcium-sensing

CaS

Homo sapiens

Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4

2.5

2021-06-30

10.1038/s41586-021-03691-0

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E191	R:R:R172	9.3	2	Yes	Yes	3	4	2	2
R:R:R172	S:S:D215	9.53	2	Yes	Yes	4	6	2	2
R:R:R172	W:W:?5	4.86	2	Yes	Yes	4	0	2	1
R:R:R172	W:W:?8	5.83	2	Yes	Yes	4	0	2	2
R:R:D484	R:R:S175	5.89	2	Yes	No	8	8	2	2
R:R:S175	W:W:?6	6	2	No	Yes	8	0	2	1
R:R:N189	W:W:?6	5.49	0	No	Yes	8	0	2	1
R:R:E191	R:R:K225	13.5	2	Yes	Yes	3	3	2	2
R:R:E191	W:W:?6	6.36	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?7	13.48	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?8	10.59	2	Yes	Yes	3	0	2	2
R:R:E191	W:W:?9	3.3	2	Yes	Yes	3	0	2	2
R:R:K225	W:W:?7	10.04	2	Yes	Yes	3	0	2	1
R:R:K225	W:W:?9	10.54	2	Yes	Yes	3	0	2	2
R:R:C482	R:R:D480	3.11	2	Yes	No	7	7	2	2
R:R:D480	R:R:D484	7.98	2	No	Yes	7	8	2	2
R:R:D480	W:W:?6	4.34	2	No	Yes	7	0	2	1
R:R:C482	W:W:?2	11.81	2	Yes	Yes	7	0	2	2
R:R:C482	W:W:?3	3.23	2	Yes	Yes	7	0	2	1
R:R:D484	W:W:?6	6.51	2	Yes	Yes	8	0	2	1
S:S:D215	W:W:?5	5.42	2	Yes	Yes	6	0	2	1
S:S:S244	W:W:?5	4.8	0	No	Yes	4	0	2	1
S:S:E251	S:S:S247	4.31	2	Yes	No	4	2	1	2
S:S:S247	W:W:?5	4.8	2	No	Yes	2	0	2	1
S:S:D248	S:S:E251	14.29	2	No	Yes	3	4	2	1
S:S:D248	W:W:?1	6.11	2	No	Yes	3	0	2	2
S:S:E251	W:W:?1	5.97	2	Yes	Yes	4	0	1	2
S:S:E251	W:W:?4	7.42	2	Yes	Yes	4	0	1	0
S:S:E251	W:W:?5	10.59	2	Yes	Yes	4	0	1	1
S:S:H254	S:S:V258	4.15	0	No	No	3	4	1	2
S:S:H254	W:W:?4	8.22	0	No	Yes	3	0	1	0
W:W:?1	W:W:?2	23.2	2	Yes	Yes	0	0	2	2
W:W:?1	W:W:?3	6.34	2	Yes	Yes	0	0	2	1
W:W:?2	W:W:?3	20.97	2	Yes	Yes	0	0	2	1
W:W:?2	W:W:?6	8.24	2	Yes	Yes	0	0	2	1
W:W:?3	W:W:?4	19.14	2	Yes	Yes	0	0	1	0
W:W:?3	W:W:?5	3.38	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?6	14.64	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?7	2.87	2	Yes	Yes	0	0	1	1
W:W:?4	W:W:?5	14.15	2	Yes	Yes	0	0	0	1
W:W:?4	W:W:?6	6.19	2	Yes	Yes	0	0	0	1
W:W:?4	W:W:?7	7.88	2	Yes	Yes	0	0	0	1
W:W:?5	W:W:?6	15.04	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?7	7.88	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?8	6.19	2	Yes	Yes	0	0	1	2
W:W:?6	W:W:?7	15.76	2	Yes	Yes	0	0	1	1
W:W:?7	W:W:?8	23.64	2	Yes	Yes	0	0	1	2
W:W:?7	W:W:?9	7.02	2	Yes	Yes	0	0	1	2
W:W:?8	W:W:?9	13.79	2	Yes	Yes	0	0	2	2
H:H:?5	S:S:H254	2.29	0	Yes	No	0	3	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	10.50
Average Nodes In Shell	25.00
Average Hubs In Shell	17.00
Average Links In Shell	50.00
Average Links Mediated by Hubs In Shell	49.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L173	R:R:R172	6.07	2	Yes	Yes	5	4	2	1
R:R:E191	R:R:R172	9.3	2	Yes	Yes	3	4	2	1
R:R:P221	R:R:R172	2.88	2	No	Yes	3	4	2	1
R:R:R172	S:S:D215	9.53	2	Yes	Yes	4	6	1	1
R:R:R172	W:W:?5	4.86	2	Yes	Yes	4	0	1	0
R:R:R172	W:W:?8	5.83	2	Yes	Yes	4	0	1	1
R:R:L173	R:R:P221	3.28	2	Yes	No	5	3	2	2
R:R:L173	S:S:R220	8.5	2	Yes	No	5	6	2	2
R:R:D484	R:R:S175	5.89	2	Yes	No	8	8	2	2
R:R:S175	W:W:?6	6	2	No	Yes	8	0	2	1
R:R:N189	W:W:?6	5.49	0	No	Yes	8	0	2	1
R:R:E191	R:R:K225	13.5	2	Yes	Yes	3	3	2	2
R:R:E191	W:W:?6	6.36	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?7	13.48	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?8	10.59	2	Yes	Yes	3	0	2	1
R:R:E191	W:W:?9	3.3	2	Yes	Yes	3	0	2	2
R:R:K225	W:W:?7	10.04	2	Yes	Yes	3	0	2	1
R:R:K225	W:W:?9	10.54	2	Yes	Yes	3	0	2	2
R:R:E228	W:W:?8	21.19	2	No	Yes	3	0	2	1
R:R:E228	W:W:?9	6.6	2	No	Yes	3	0	2	2
R:R:C482	R:R:D480	3.11	2	Yes	No	7	7	2	2
R:R:D480	R:R:D484	7.98	2	No	Yes	7	8	2	2
R:R:D480	W:W:?6	4.34	2	No	Yes	7	0	2	1
R:R:C482	W:W:?2	11.81	2	Yes	Yes	7	0	2	2
R:R:C482	W:W:?3	3.23	2	Yes	Yes	7	0	2	1
R:R:D484	W:W:?6	6.51	2	Yes	Yes	8	0	2	1
S:S:D215	S:S:R220	8.34	2	Yes	No	6	6	1	2
S:S:D215	S:S:L242	6.79	2	Yes	No	6	4	1	2
S:S:D215	W:W:?5	5.42	2	Yes	Yes	6	0	1	0
S:S:E241	W:W:?8	8.47	0	No	Yes	5	0	2	1
S:S:S244	W:W:?5	4.8	0	No	Yes	4	0	1	0
S:S:E251	S:S:S247	4.31	2	Yes	No	4	2	1	1
S:S:I252	S:S:S247	3.1	2	No	No	4	2	2	1
S:S:S247	W:W:?5	4.8	2	No	Yes	2	0	1	0
S:S:D248	S:S:E251	14.29	2	No	Yes	3	4	2	1
S:S:D248	W:W:?1	6.11	2	No	Yes	3	0	2	2
S:S:E251	W:W:?1	5.97	2	Yes	Yes	4	0	1	2
S:S:E251	W:W:?4	7.42	2	Yes	Yes	4	0	1	1
S:S:E251	W:W:?5	10.59	2	Yes	Yes	4	0	1	0
S:S:H254	W:W:?4	8.22	0	No	Yes	3	0	2	1
W:W:?1	W:W:?2	23.2	2	Yes	Yes	0	0	2	2
W:W:?1	W:W:?3	6.34	2	Yes	Yes	0	0	2	1
W:W:?2	W:W:?3	20.97	2	Yes	Yes	0	0	2	1
W:W:?2	W:W:?6	8.24	2	Yes	Yes	0	0	2	1
W:W:?3	W:W:?4	19.14	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?5	3.38	2	Yes	Yes	0	0	1	0
W:W:?3	W:W:?6	14.64	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?7	2.87	2	Yes	Yes	0	0	1	1
W:W:?4	W:W:?5	14.15	2	Yes	Yes	0	0	1	0
W:W:?4	W:W:?6	6.19	2	Yes	Yes	0	0	1	1
W:W:?4	W:W:?7	7.88	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?6	15.04	2	Yes	Yes	0	0	0	1
W:W:?5	W:W:?7	7.88	2	Yes	Yes	0	0	0	1
W:W:?5	W:W:?8	6.19	2	Yes	Yes	0	0	0	1
W:W:?6	W:W:?7	15.76	2	Yes	Yes	0	0	1	1
W:W:?7	W:W:?8	23.64	2	Yes	Yes	0	0	1	1
W:W:?7	W:W:?9	7.02	2	Yes	Yes	0	0	1	2
W:W:?8	W:W:?9	13.79	2	Yes	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	7.71
Average Nodes In Shell	30.00
Average Hubs In Shell	17.00
Average Links In Shell	58.00
Average Links Mediated by Hubs In Shell	57.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E191	R:R:R172	9.3	2	Yes	Yes	3	4	1	2
R:R:R172	S:S:D215	9.53	2	Yes	Yes	4	6	2	2
R:R:R172	W:W:?5	4.86	2	Yes	Yes	4	0	2	1
R:R:R172	W:W:?8	5.83	2	Yes	Yes	4	0	2	2
R:R:R185	R:R:S175	3.95	2	Yes	No	9	8	2	1
R:R:D484	R:R:S175	5.89	2	Yes	No	8	8	1	1
R:R:S175	W:W:?6	6	2	No	Yes	8	0	1	0
R:R:N189	R:R:R185	4.82	0	No	Yes	8	9	1	2
R:R:D484	R:R:R185	9.53	2	Yes	Yes	8	9	1	2
R:R:N189	W:W:?6	5.49	0	No	Yes	8	0	1	0
R:R:E191	R:R:K225	13.5	2	Yes	Yes	3	3	1	2
R:R:E191	W:W:?6	6.36	2	Yes	Yes	3	0	1	0
R:R:E191	W:W:?7	13.48	2	Yes	Yes	3	0	1	1
R:R:E191	W:W:?8	10.59	2	Yes	Yes	3	0	1	2
R:R:E191	W:W:?9	3.3	2	Yes	Yes	3	0	1	2
R:R:K225	W:W:?7	10.04	2	Yes	Yes	3	0	2	1
R:R:K225	W:W:?9	10.54	2	Yes	Yes	3	0	2	2
R:R:C482	R:R:D480	3.11	2	Yes	No	7	7	2	1
R:R:D480	R:R:D484	7.98	2	No	Yes	7	8	1	1
R:R:D480	W:W:?6	4.34	2	No	Yes	7	0	1	0
R:R:C482	W:W:?2	11.81	2	Yes	Yes	7	0	2	1
R:R:C482	W:W:?3	3.23	2	Yes	Yes	7	0	2	1
R:R:D484	W:W:?6	6.51	2	Yes	Yes	8	0	1	0
S:S:D215	W:W:?5	5.42	2	Yes	Yes	6	0	2	1
S:S:S244	W:W:?5	4.8	0	No	Yes	4	0	2	1
S:S:E251	S:S:S247	4.31	2	Yes	No	4	2	2	2
S:S:S247	W:W:?5	4.8	2	No	Yes	2	0	2	1
S:S:E251	W:W:?1	5.97	2	Yes	Yes	4	0	2	2
S:S:E251	W:W:?4	7.42	2	Yes	Yes	4	0	2	1
S:S:E251	W:W:?5	10.59	2	Yes	Yes	4	0	2	1
S:S:H254	W:W:?4	8.22	0	No	Yes	3	0	2	1
W:W:?1	W:W:?2	23.2	2	Yes	Yes	0	0	2	1
W:W:?1	W:W:?3	6.34	2	Yes	Yes	0	0	2	1
W:W:?2	W:W:?3	20.97	2	Yes	Yes	0	0	1	1
W:W:?2	W:W:?6	8.24	2	Yes	Yes	0	0	1	0
W:W:?3	W:W:?4	19.14	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?5	3.38	2	Yes	Yes	0	0	1	1
W:W:?3	W:W:?6	14.64	2	Yes	Yes	0	0	1	0
W:W:?3	W:W:?7	2.87	2	Yes	Yes	0	0	1	1
W:W:?4	W:W:?5	14.15	2	Yes	Yes	0	0	1	1
W:W:?4	W:W:?6	6.19	2	Yes	Yes	0	0	1	0
W:W:?4	W:W:?7	7.88	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?6	15.04	2	Yes	Yes	0	0	1	0
W:W:?5	W:W:?7	7.88	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?8	6.19	2	Yes	Yes	0	0	1	2
W:W:?6	W:W:?7	15.76	2	Yes	Yes	0	0	0	1
W:W:?7	W:W:?8	23.64	2	Yes	Yes	0	0	1	2
W:W:?7	W:W:?9	7.02	2	Yes	Yes	0	0	1	2
W:W:?8	W:W:?9	13.79	2	Yes	Yes	0	0	2	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.86
Average Nodes In Shell	23.00
Average Hubs In Shell	17.00
Average Links In Shell	49.00
Average Links Mediated by Hubs In Shell	49.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L173	R:R:R172	6.07	2	Yes	Yes	5	4	2	1
R:R:E191	R:R:R172	9.3	2	Yes	Yes	3	4	1	1
R:R:P221	R:R:R172	2.88	2	No	Yes	3	4	2	1
R:R:R172	S:S:D215	9.53	2	Yes	Yes	4	6	1	2
R:R:R172	W:W:?5	4.86	2	Yes	Yes	4	0	1	1
R:R:R172	W:W:?8	5.83	2	Yes	Yes	4	0	1	0
R:R:L173	R:R:P221	3.28	2	Yes	No	5	3	2	2
R:R:E191	R:R:K225	13.5	2	Yes	Yes	3	3	1	2
R:R:E191	W:W:?6	6.36	2	Yes	Yes	3	0	1	2
R:R:E191	W:W:?7	13.48	2	Yes	Yes	3	0	1	1
R:R:E191	W:W:?8	10.59	2	Yes	Yes	3	0	1	0
R:R:E191	W:W:?9	3.3	2	Yes	Yes	3	0	1	1
R:R:K225	W:W:?7	10.04	2	Yes	Yes	3	0	2	1
R:R:K225	W:W:?9	10.54	2	Yes	Yes	3	0	2	1
R:R:E228	W:W:?8	21.19	2	No	Yes	3	0	1	0
R:R:E228	W:W:?9	6.6	2	No	Yes	3	0	1	1
S:S:D215	W:W:?5	5.42	2	Yes	Yes	6	0	2	1
S:S:E241	S:S:V255	8.56	0	No	No	5	5	1	2
S:S:E241	S:S:V258	9.98	0	No	No	5	4	1	2
S:S:E241	W:W:?8	8.47	0	No	Yes	5	0	1	0
S:S:S244	W:W:?5	4.8	0	No	Yes	4	0	2	1
S:S:E251	S:S:S247	4.31	2	Yes	No	4	2	2	2
S:S:S247	W:W:?5	4.8	2	No	Yes	2	0	2	1
S:S:E251	W:W:?4	7.42	2	Yes	Yes	4	0	2	2
S:S:E251	W:W:?5	10.59	2	Yes	Yes	4	0	2	1
W:W:?3	W:W:?4	19.14	2	Yes	Yes	0	0	2	2
W:W:?3	W:W:?5	3.38	2	Yes	Yes	0	0	2	1
W:W:?3	W:W:?6	14.64	2	Yes	Yes	0	0	2	2
W:W:?3	W:W:?7	2.87	2	Yes	Yes	0	0	2	1
W:W:?4	W:W:?5	14.15	2	Yes	Yes	0	0	2	1
W:W:?4	W:W:?6	6.19	2	Yes	Yes	0	0	2	2
W:W:?4	W:W:?7	7.88	2	Yes	Yes	0	0	2	1
W:W:?5	W:W:?6	15.04	2	Yes	Yes	0	0	1	2
W:W:?5	W:W:?7	7.88	2	Yes	Yes	0	0	1	1
W:W:?5	W:W:?8	6.19	2	Yes	Yes	0	0	1	0
W:W:?6	W:W:?7	15.76	2	Yes	Yes	0	0	2	1
W:W:?7	W:W:?8	23.64	2	Yes	Yes	0	0	1	0
W:W:?7	W:W:?9	7.02	2	Yes	Yes	0	0	1	1
W:W:?8	W:W:?9	13.79	2	Yes	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	5.00
Average Interaction Strength	12.81
Average Nodes In Shell	20.00
Average Hubs In Shell	13.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	37.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D215	S:S:R172	9.53	1	Yes	Yes	6	4	2	2
R:R:D215	X:X:?5	4.34	1	Yes	Yes	6	0	2	1
R:R:E241	R:R:H254	3.69	1	Yes	No	5	3	2	1
R:R:E241	R:R:V258	9.98	1	Yes	No	5	4	2	2
R:R:E241	X:X:?8	7.42	1	Yes	Yes	5	0	2	1
R:R:S244	R:R:S247	4.89	1	No	Yes	4	2	2	2
R:R:S244	X:X:?5	4.8	1	No	Yes	4	0	2	1
R:R:E251	R:R:S247	4.31	1	Yes	Yes	4	2	1	2
R:R:S247	X:X:?5	7.2	1	Yes	Yes	2	0	2	1
R:R:D248	R:R:E251	16.89	1	No	Yes	3	4	2	1
R:R:D248	X:X:?1	6.11	1	No	Yes	3	0	2	1
R:R:E251	X:X:?1	5.97	1	Yes	Yes	4	0	1	1
R:R:E251	X:X:?4	6.36	1	Yes	Yes	4	0	1	0
R:R:E251	X:X:?5	12.71	1	Yes	Yes	4	0	1	1
R:R:H254	R:R:V258	5.54	1	No	No	3	4	1	2
R:R:H254	X:X:?4	7.19	1	No	Yes	3	0	1	0
S:S:E191	S:S:R172	8.14	1	Yes	Yes	3	4	2	2
S:S:R172	X:X:?5	4.86	1	Yes	Yes	4	0	2	1
S:S:R172	X:X:?6	4.86	1	Yes	Yes	4	0	2	1
S:S:R172	X:X:?8	7.77	1	Yes	Yes	4	0	2	1
S:S:R172	X:X:?9	3.03	1	Yes	Yes	4	0	2	2
S:S:D484	S:S:S175	5.89	1	Yes	No	8	8	2	2
S:S:S175	X:X:?6	6	1	No	Yes	8	0	2	1
S:S:D484	S:S:N189	5.39	1	Yes	No	8	8	2	2
S:S:N189	X:X:?6	9.88	1	No	Yes	8	0	2	1
S:S:E191	S:S:K225	17.55	1	Yes	Yes	3	3	2	2
S:S:E191	X:X:?6	8.47	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?7	9.44	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?8	3.18	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?9	6.6	1	Yes	Yes	3	0	2	2
S:S:E228	S:S:K225	2.7	1	No	Yes	3	3	2	2
S:S:K225	X:X:?7	11.48	1	Yes	Yes	3	0	2	1
S:S:K225	X:X:?9	10.54	1	Yes	Yes	3	0	2	2
S:S:E228	X:X:?8	9.53	1	No	Yes	3	0	2	1
S:S:E228	X:X:?9	3.3	1	No	Yes	3	0	2	2
S:S:D480	S:S:D484	9.31	1	No	Yes	7	8	2	2
S:S:D480	X:X:?6	5.42	1	No	Yes	7	0	2	1
S:S:C482	S:S:D484	4.67	1	Yes	Yes	7	8	2	2
S:S:C482	X:X:?2	11.81	1	Yes	Yes	7	0	2	1
S:S:C482	X:X:?3	4.84	1	Yes	Yes	7	0	2	1
S:S:C482	X:X:?6	3.81	1	Yes	Yes	7	0	2	1
S:S:D484	X:X:?6	6.51	1	Yes	Yes	8	0	2	1
X:X:?1	X:X:?2	27.06	1	Yes	Yes	0	0	1	1
X:X:?1	X:X:?3	6.34	1	Yes	Yes	0	0	1	1
X:X:?1	X:X:?4	6.64	1	Yes	Yes	0	0	1	0
X:X:?2	X:X:?3	20.97	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?4	5.15	1	Yes	Yes	0	0	1	0
X:X:?2	X:X:?5	5.15	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?6	5.15	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?4	16.89	1	Yes	Yes	0	0	1	0
X:X:?3	X:X:?6	16.89	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?7	2.87	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?5	15.92	1	Yes	Yes	0	0	0	1
X:X:?4	X:X:?6	6.19	1	Yes	Yes	0	0	0	1
X:X:?4	X:X:?7	5.63	1	Yes	Yes	0	0	0	1
X:X:?4	X:X:?8	4.42	1	Yes	Yes	0	0	0	1
X:X:?5	X:X:?6	15.92	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?7	7.88	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?8	8.85	1	Yes	Yes	0	0	1	1
X:X:?6	X:X:?7	19.14	1	Yes	Yes	0	0	1	1
X:X:?6	X:X:?8	4.42	1	Yes	Yes	0	0	1	1
X:X:?7	X:X:?8	20.26	1	Yes	Yes	0	0	1	1
X:X:?7	X:X:?9	7.02	1	Yes	Yes	0	0	1	2
X:X:?8	X:X:?9	13.79	1	Yes	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	8.27
Average Nodes In Shell	26.00
Average Hubs In Shell	18.00
Average Links In Shell	64.00
Average Links Mediated by Hubs In Shell	63.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D215	R:R:R220	9.53	1	Yes	No	6	6	1	2
R:R:D215	R:R:L242	10.86	1	Yes	No	6	4	1	2
R:R:D215	S:S:R172	9.53	1	Yes	Yes	6	4	1	1
R:R:D215	X:X:?5	4.34	1	Yes	Yes	6	0	1	0
R:R:R220	S:S:L173	6.07	0	No	Yes	6	5	2	2
R:R:E241	R:R:H254	3.69	1	Yes	No	5	3	2	2
R:R:E241	X:X:?8	7.42	1	Yes	Yes	5	0	2	1
R:R:S244	R:R:S247	4.89	1	No	Yes	4	2	1	1
R:R:S244	X:X:?5	4.8	1	No	Yes	4	0	1	0
R:R:E251	R:R:S247	4.31	1	Yes	Yes	4	2	1	1
R:R:I252	R:R:S247	3.1	0	No	Yes	4	2	2	1
R:R:S247	X:X:?5	7.2	1	Yes	Yes	2	0	1	0
R:R:D248	R:R:E251	16.89	1	No	Yes	3	4	2	1
R:R:D248	X:X:?1	6.11	1	No	Yes	3	0	2	2
R:R:E251	X:X:?1	5.97	1	Yes	Yes	4	0	1	2
R:R:E251	X:X:?4	6.36	1	Yes	Yes	4	0	1	1
R:R:E251	X:X:?5	12.71	1	Yes	Yes	4	0	1	0
R:R:H254	X:X:?4	7.19	1	No	Yes	3	0	2	1
S:S:L173	S:S:R172	7.29	1	Yes	Yes	5	4	2	1
S:S:E191	S:S:R172	8.14	1	Yes	Yes	3	4	2	1
S:S:P221	S:S:R172	2.88	1	No	Yes	3	4	2	1
S:S:R172	X:X:?5	4.86	1	Yes	Yes	4	0	1	0
S:S:R172	X:X:?6	4.86	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?8	7.77	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?9	3.03	1	Yes	Yes	4	0	1	2
S:S:L173	S:S:P221	3.28	1	Yes	No	5	3	2	2
S:S:D484	S:S:S175	5.89	1	Yes	No	8	8	2	2
S:S:S175	X:X:?6	6	1	No	Yes	8	0	2	1
S:S:D484	S:S:N189	5.39	1	Yes	No	8	8	2	2
S:S:N189	X:X:?6	9.88	1	No	Yes	8	0	2	1
S:S:E191	S:S:K225	17.55	1	Yes	Yes	3	3	2	2
S:S:E191	X:X:?6	8.47	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?7	9.44	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?8	3.18	1	Yes	Yes	3	0	2	1
S:S:E191	X:X:?9	6.6	1	Yes	Yes	3	0	2	2
S:S:E228	S:S:K225	2.7	1	No	Yes	3	3	2	2
S:S:K225	X:X:?7	11.48	1	Yes	Yes	3	0	2	1
S:S:K225	X:X:?9	10.54	1	Yes	Yes	3	0	2	2
S:S:E228	X:X:?8	9.53	1	No	Yes	3	0	2	1
S:S:E228	X:X:?9	3.3	1	No	Yes	3	0	2	2
S:S:D480	S:S:D484	9.31	1	No	Yes	7	8	2	2
S:S:D480	X:X:?6	5.42	1	No	Yes	7	0	2	1
S:S:C482	S:S:D484	4.67	1	Yes	Yes	7	8	2	2
S:S:C482	X:X:?2	11.81	1	Yes	Yes	7	0	2	1
S:S:C482	X:X:?3	4.84	1	Yes	Yes	7	0	2	2
S:S:C482	X:X:?6	3.81	1	Yes	Yes	7	0	2	1
S:S:D484	X:X:?6	6.51	1	Yes	Yes	8	0	2	1
X:X:?1	X:X:?2	27.06	1	Yes	Yes	0	0	2	1
X:X:?1	X:X:?3	6.34	1	Yes	Yes	0	0	2	2
X:X:?1	X:X:?4	6.64	1	Yes	Yes	0	0	2	1
X:X:?2	X:X:?3	20.97	1	Yes	Yes	0	0	1	2
X:X:?2	X:X:?4	5.15	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?5	5.15	1	Yes	Yes	0	0	1	0
X:X:?2	X:X:?6	5.15	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?4	16.89	1	Yes	Yes	0	0	2	1
X:X:?3	X:X:?6	16.89	1	Yes	Yes	0	0	2	1
X:X:?3	X:X:?7	2.87	1	Yes	Yes	0	0	2	1
X:X:?4	X:X:?5	15.92	1	Yes	Yes	0	0	1	0
X:X:?4	X:X:?6	6.19	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?7	5.63	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?8	4.42	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?6	15.92	1	Yes	Yes	0	0	0	1
X:X:?5	X:X:?7	7.88	1	Yes	Yes	0	0	0	1
X:X:?5	X:X:?8	8.85	1	Yes	Yes	0	0	0	1
X:X:?6	X:X:?7	19.14	1	Yes	Yes	0	0	1	1
X:X:?6	X:X:?8	4.42	1	Yes	Yes	0	0	1	1
X:X:?7	X:X:?8	20.26	1	Yes	Yes	0	0	1	1
X:X:?7	X:X:?9	7.02	1	Yes	Yes	0	0	1	2
X:X:?8	X:X:?9	13.79	1	Yes	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	9.00
Average Interaction Strength	8.76
Average Nodes In Shell	30.00
Average Hubs In Shell	19.00
Average Links In Shell	69.00
Average Links Mediated by Hubs In Shell	69.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D215	S:S:R172	9.53	1	Yes	Yes	6	4	2	1
R:R:D215	X:X:?5	4.34	1	Yes	Yes	6	0	2	1
R:R:E241	R:R:H254	3.69	1	Yes	No	5	3	2	2
R:R:E241	X:X:?8	7.42	1	Yes	Yes	5	0	2	1
R:R:S244	R:R:S247	4.89	1	No	Yes	4	2	2	2
R:R:S244	X:X:?5	4.8	1	No	Yes	4	0	2	1
R:R:E251	R:R:S247	4.31	1	Yes	Yes	4	2	2	2
R:R:S247	X:X:?5	7.2	1	Yes	Yes	2	0	2	1
R:R:E251	X:X:?1	5.97	1	Yes	Yes	4	0	2	2
R:R:E251	X:X:?4	6.36	1	Yes	Yes	4	0	2	1
R:R:E251	X:X:?5	12.71	1	Yes	Yes	4	0	2	1
R:R:H254	X:X:?4	7.19	1	No	Yes	3	0	2	1
S:S:L173	S:S:R172	7.29	1	Yes	Yes	5	4	2	1
S:S:E191	S:S:R172	8.14	1	Yes	Yes	3	4	1	1
S:S:P221	S:S:R172	2.88	1	No	Yes	3	4	2	1
S:S:R172	X:X:?5	4.86	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?6	4.86	1	Yes	Yes	4	0	1	0
S:S:R172	X:X:?8	7.77	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?9	3.03	1	Yes	Yes	4	0	1	2
S:S:L173	S:S:P221	3.28	1	Yes	No	5	3	2	2
S:S:R185	S:S:S175	5.27	1	Yes	No	9	8	2	1
S:S:D484	S:S:S175	5.89	1	Yes	No	8	8	1	1
S:S:S175	X:X:?6	6	1	No	Yes	8	0	1	0
S:S:N189	S:S:R185	6.03	1	No	Yes	8	9	1	2
S:S:D484	S:S:R185	9.53	1	Yes	Yes	8	9	1	2
S:S:D484	S:S:N189	5.39	1	Yes	No	8	8	1	1
S:S:N189	X:X:?6	9.88	1	No	Yes	8	0	1	0
S:S:E191	S:S:K225	17.55	1	Yes	Yes	3	3	1	2
S:S:E191	X:X:?6	8.47	1	Yes	Yes	3	0	1	0
S:S:E191	X:X:?7	9.44	1	Yes	Yes	3	0	1	1
S:S:E191	X:X:?8	3.18	1	Yes	Yes	3	0	1	1
S:S:E191	X:X:?9	6.6	1	Yes	Yes	3	0	1	2
S:S:E228	S:S:K225	2.7	1	No	Yes	3	3	2	2
S:S:K225	X:X:?7	11.48	1	Yes	Yes	3	0	2	1
S:S:K225	X:X:?9	10.54	1	Yes	Yes	3	0	2	2
S:S:E228	X:X:?8	9.53	1	No	Yes	3	0	2	1
S:S:E228	X:X:?9	3.3	1	No	Yes	3	0	2	2
S:S:D480	S:S:E481	6.5	1	No	No	7	4	1	2
S:S:D480	S:S:D484	9.31	1	No	Yes	7	8	1	1
S:S:D480	X:X:?6	5.42	1	No	Yes	7	0	1	0
S:S:C482	S:S:E481	3.04	1	Yes	No	7	4	1	2
S:S:C482	S:S:D484	4.67	1	Yes	Yes	7	8	1	1
S:S:C482	X:X:?2	11.81	1	Yes	Yes	7	0	1	1
S:S:C482	X:X:?3	4.84	1	Yes	Yes	7	0	1	1
S:S:C482	X:X:?6	3.81	1	Yes	Yes	7	0	1	0
S:S:D484	X:X:?6	6.51	1	Yes	Yes	8	0	1	0
X:X:?1	X:X:?2	27.06	1	Yes	Yes	0	0	2	1
X:X:?1	X:X:?3	6.34	1	Yes	Yes	0	0	2	1
X:X:?1	X:X:?4	6.64	1	Yes	Yes	0	0	2	1
X:X:?2	X:X:?3	20.97	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?4	5.15	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?5	5.15	1	Yes	Yes	0	0	1	1
X:X:?2	X:X:?6	5.15	1	Yes	Yes	0	0	1	0
X:X:?3	X:X:?4	16.89	1	Yes	Yes	0	0	1	1
X:X:?3	X:X:?6	16.89	1	Yes	Yes	0	0	1	0
X:X:?3	X:X:?7	2.87	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?5	15.92	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?6	6.19	1	Yes	Yes	0	0	1	0
X:X:?4	X:X:?7	5.63	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?8	4.42	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?6	15.92	1	Yes	Yes	0	0	1	0
X:X:?5	X:X:?7	7.88	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?8	8.85	1	Yes	Yes	0	0	1	1
X:X:?6	X:X:?7	19.14	1	Yes	Yes	0	0	0	1
X:X:?6	X:X:?8	4.42	1	Yes	Yes	0	0	0	1
X:X:?7	X:X:?8	20.26	1	Yes	Yes	0	0	1	1
X:X:?7	X:X:?9	7.02	1	Yes	Yes	0	0	1	2
X:X:?8	X:X:?9	13.79	1	Yes	Yes	0	0	1	2

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	10.00
Average Interaction Strength	8.67
Average Nodes In Shell	28.00
Average Hubs In Shell	20.00
Average Links In Shell	68.00
Average Links Mediated by Hubs In Shell	67.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAR in 7M3G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D215	S:S:R172	9.53	1	Yes	Yes	6	4	2	1
R:R:D215	X:X:?5	4.34	1	Yes	Yes	6	0	2	1
R:R:E241	R:R:H254	3.69	1	Yes	No	5	3	1	2
R:R:E241	R:R:V255	4.28	1	Yes	Yes	5	5	1	2
R:R:E241	R:R:V258	9.98	1	Yes	No	5	4	1	2
R:R:E241	X:X:?8	7.42	1	Yes	Yes	5	0	1	0
R:R:S244	R:R:S247	4.89	1	No	Yes	4	2	2	2
R:R:S244	X:X:?5	4.8	1	No	Yes	4	0	2	1
R:R:E251	R:R:S247	4.31	1	Yes	Yes	4	2	2	2
R:R:S247	X:X:?5	7.2	1	Yes	Yes	2	0	2	1
R:R:E251	X:X:?1	5.97	1	Yes	Yes	4	0	2	2
R:R:E251	X:X:?4	6.36	1	Yes	Yes	4	0	2	1
R:R:E251	X:X:?5	12.71	1	Yes	Yes	4	0	2	1
R:R:H254	R:R:V258	5.54	1	No	No	3	4	2	2
R:R:H254	X:X:?4	7.19	1	No	Yes	3	0	2	1
S:S:L173	S:S:R172	7.29	1	Yes	Yes	5	4	2	1
S:S:E191	S:S:R172	8.14	1	Yes	Yes	3	4	1	1
S:S:P221	S:S:R172	2.88	1	No	Yes	3	4	2	1
S:S:R172	X:X:?5	4.86	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?6	4.86	1	Yes	Yes	4	0	1	1
S:S:R172	X:X:?8	7.77	1	Yes	Yes	4	0	1	0
S:S:R172	X:X:?9	3.03	1	Yes	Yes	4	0	1	1
S:S:L173	S:S:P221	3.28	1	Yes	No	5	3	2	2
S:S:D484	S:S:S175	5.89	1	Yes	No	8	8	2	2
S:S:S175	X:X:?6	6	1	No	Yes	8	0	2	1
S:S:D484	S:S:N189	5.39	1	Yes	No	8	8	2	2
S:S:N189	X:X:?6	9.88	1	No	Yes	8	0	2	1
S:S:E191	S:S:K225	17.55	1	Yes	Yes	3	3	1	2
S:S:E191	X:X:?6	8.47	1	Yes	Yes	3	0	1	1
S:S:E191	X:X:?7	9.44	1	Yes	Yes	3	0	1	1
S:S:E191	X:X:?8	3.18	1	Yes	Yes	3	0	1	0
S:S:E191	X:X:?9	6.6	1	Yes	Yes	3	0	1	1
S:S:E228	S:S:K225	2.7	1	No	Yes	3	3	1	2
S:S:K225	X:X:?7	11.48	1	Yes	Yes	3	0	2	1
S:S:K225	X:X:?9	10.54	1	Yes	Yes	3	0	2	1
S:S:E228	X:X:?8	9.53	1	No	Yes	3	0	1	0
S:S:E228	X:X:?9	3.3	1	No	Yes	3	0	1	1
S:S:D480	S:S:D484	9.31	1	No	Yes	7	8	2	2
S:S:D480	X:X:?6	5.42	1	No	Yes	7	0	2	1
S:S:C482	S:S:D484	4.67	1	Yes	Yes	7	8	2	2
S:S:C482	X:X:?2	11.81	1	Yes	Yes	7	0	2	2
S:S:C482	X:X:?3	4.84	1	Yes	Yes	7	0	2	2
S:S:C482	X:X:?6	3.81	1	Yes	Yes	7	0	2	1
S:S:D484	X:X:?6	6.51	1	Yes	Yes	8	0	2	1
X:X:?1	X:X:?2	27.06	1	Yes	Yes	0	0	2	2
X:X:?1	X:X:?3	6.34	1	Yes	Yes	0	0	2	2
X:X:?1	X:X:?4	6.64	1	Yes	Yes	0	0	2	1
X:X:?2	X:X:?3	20.97	1	Yes	Yes	0	0	2	2
X:X:?2	X:X:?4	5.15	1	Yes	Yes	0	0	2	1
X:X:?2	X:X:?5	5.15	1	Yes	Yes	0	0	2	1
X:X:?2	X:X:?6	5.15	1	Yes	Yes	0	0	2	1
X:X:?3	X:X:?4	16.89	1	Yes	Yes	0	0	2	1
X:X:?3	X:X:?6	16.89	1	Yes	Yes	0	0	2	1
X:X:?3	X:X:?7	2.87	1	Yes	Yes	0	0	2	1
X:X:?4	X:X:?5	15.92	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?6	6.19	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?7	5.63	1	Yes	Yes	0	0	1	1
X:X:?4	X:X:?8	4.42	1	Yes	Yes	0	0	1	0
X:X:?5	X:X:?6	15.92	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?7	7.88	1	Yes	Yes	0	0	1	1
X:X:?5	X:X:?8	8.85	1	Yes	Yes	0	0	1	0
X:X:?6	X:X:?7	19.14	1	Yes	Yes	0	0	1	1
X:X:?6	X:X:?8	4.42	1	Yes	Yes	0	0	1	0
X:X:?7	X:X:?8	20.26	1	Yes	Yes	0	0	1	0
X:X:?7	X:X:?9	7.02	1	Yes	Yes	0	0	1	1
X:X:?8	X:X:?9	13.79	1	Yes	Yes	0	0	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	8.00
Average Interaction Strength	8.85
Average Nodes In Shell	28.00
Average Hubs In Shell	20.00
Average Links In Shell	66.00
Average Links Mediated by Hubs In Shell	65.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7Y65

Peptide

Complement peptide

C5A1

Homo Sapiens

C5a peptide

Gi1/Beta1/Gamma2

3.2

2023-03-01

10.1038/s41422-023-00779-2

A 2D representation of the interactions of DAR in 7Y65
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?4	L:L:?5	25.28	2	Yes	Yes	0	0	1	1
L:L:?4	L:L:?6	2.06	2	Yes	Yes	0	0	1	0
L:L:?4	R:R:L92	6.43	2	Yes	No	0	6	1	2
L:L:?4	R:R:P113	3.05	2	Yes	No	0	6	1	2
L:L:?4	R:R:R175	5.64	2	Yes	Yes	0	5	1	2
L:L:?5	L:L:?6	31.23	2	Yes	Yes	0	0	1	0
L:L:?5	R:R:L92	2.37	2	Yes	No	0	6	1	2
L:L:?5	R:R:I116	6.1	2	Yes	No	0	6	1	2
L:L:?5	R:R:L117	2.37	2	Yes	No	0	4	1	2
L:L:?5	R:R:V286	3.82	2	Yes	Yes	0	5	1	1
L:L:?6	R:R:V190	3.57	2	Yes	No	0	5	0	1
L:L:?6	R:R:Y258	15.93	2	Yes	Yes	0	7	0	1
L:L:?6	R:R:D282	10.85	2	Yes	No	0	4	0	1
L:L:?6	R:R:V286	2.38	2	Yes	Yes	0	5	0	1
R:R:F44	R:R:V286	2.62	2	Yes	Yes	7	5	2	1
R:R:P113	R:R:R175	8.65	2	No	Yes	6	5	2	2
R:R:R175	R:R:V190	2.62	2	Yes	No	5	5	2	1
R:R:V190	R:R:Y192	7.57	0	No	Yes	5	5	1	2
R:R:W255	R:R:Y258	2.89	2	Yes	Yes	9	7	2	1
R:R:Q259	R:R:W255	5.48	2	No	Yes	8	9	2	2
R:R:A289	R:R:W255	3.89	2	No	Yes	8	9	2	2
R:R:Q259	R:R:Y258	7.89	2	No	Yes	8	7	2	1
R:R:V286	R:R:Y258	5.05	2	Yes	Yes	5	7	1	1
R:R:A289	R:R:Y258	5.34	2	No	Yes	8	7	2	1
R:R:D282	R:R:K279	9.68	0	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	11.00
Average Nodes In Shell	18.00
Average Hubs In Shell	9.00
Average Links In Shell	25.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7Y67

Peptide

Complement peptide

C5A1

Homo Sapiens

C089 peptide

Gi1/Beta1/Gamma2

2.8

2023-03-01

10.1038/s41422-023-00779-2

A 2D representation of the interactions of DAR in 7Y67
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F44	R:R:V286	2.62	0	No	Yes	7	5	2	1
R:R:W255	R:R:Y258	7.72	28	Yes	No	9	7	2	1
R:R:Q259	R:R:Y258	5.64	0	No	No	8	7	2	1
L:L:?6	R:R:Y258	14.06	9	Yes	No	0	7	0	1
R:R:G262	R:R:T261	3.64	9	No	Yes	5	4	1	1
R:R:C285	R:R:T261	8.45	0	No	Yes	6	4	2	1
L:L:?6	R:R:T261	3.54	9	Yes	Yes	0	4	0	1
L:L:?6	R:R:G262	4.1	9	Yes	No	0	5	0	1
R:R:D282	R:R:M265	6.93	9	Yes	No	4	4	1	2
R:R:D282	R:R:V286	4.38	9	Yes	Yes	4	5	1	1
L:L:W5	R:R:D282	5.58	9	Yes	Yes	0	4	1	1
L:L:?6	R:R:D282	8.68	9	Yes	Yes	0	4	0	1
L:L:W5	R:R:V286	22.07	9	Yes	Yes	0	5	1	1
L:L:?6	R:R:V286	5.95	9	Yes	Yes	0	5	0	1
L:L:?4	L:L:W5	4.23	0	Yes	Yes	0	0	2	1
L:L:?6	L:L:W5	9.1	9	Yes	Yes	0	0	0	1
R:R:T261	R:R:V260	1.59	9	Yes	No	4	6	1	2

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	7.57
Average Nodes In Shell	14.00
Average Hubs In Shell	7.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	16.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8HPT

Peptide

Complement peptide

C5a1

Mus Musculus

C5a anaphylatoxin C-terminal peptide

Go/Beta1/Gamma2

3.39

2023-10-18

10.1016/j.cell.2023.09.020

A 2D representation of the interactions of DAR in 8HPT
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?5	R:R:L92	3.55	4	Yes	No	0	6	1	2
L:L:?5	R:R:I116	4.88	4	Yes	No	0	6	1	2
R:R:L117	R:R:Y121	8.21	0	No	No	4	7	2	2
L:L:?5	R:R:L117	4.74	4	Yes	No	0	4	1	2
R:R:R207	R:R:Y121	10.29	4	Yes	No	5	7	1	2
R:R:P170	R:R:R207	4.32	0	No	Yes	7	5	2	1
L:L:?4	R:R:R175	5.64	4	Yes	Yes	0	4	2	2
L:L:?5	R:R:R175	3.12	4	Yes	Yes	0	4	1	2
L:L:?6	R:R:R207	2.91	4	Yes	Yes	0	5	0	1
R:R:W256	R:R:Y259	6.75	4	Yes	Yes	8	7	2	1
R:R:Q260	R:R:Y259	3.38	0	No	Yes	8	7	2	1
L:L:?5	R:R:Y259	4.01	4	Yes	Yes	0	7	1	1
L:L:?6	R:R:Y259	17.81	4	Yes	Yes	0	7	0	1
R:R:T262	R:R:V279	3.17	0	Yes	No	5	4	1	2
R:R:C286	R:R:T262	6.76	0	No	Yes	7	5	2	1
L:L:?6	R:R:T262	4.71	4	Yes	Yes	0	5	0	1
L:L:?6	R:R:G263	5.47	4	Yes	No	0	6	0	1
L:L:?6	R:R:N283	14.27	4	Yes	No	0	4	0	1
L:L:?5	R:R:V287	6.37	4	Yes	No	0	5	1	2
L:L:?4	L:L:?5	25.28	4	Yes	Yes	0	0	2	1
L:L:?5	L:L:?6	28.39	4	Yes	Yes	0	0	1	0
R:R:T262	R:R:V261	1.59	0	Yes	No	5	6	1	2
R:R:L167	R:R:L206	1.38	4	No	No	5	3	2	2
R:R:L167	R:R:R207	1.21	4	No	Yes	5	5	2	1
R:R:L206	R:R:R207	1.21	4	No	Yes	3	5	2	1

Statistics	Value
Average Number Of Links	6.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	12.26
Average Nodes In Shell	22.00
Average Hubs In Shell	8.00
Average Links In Shell	25.00
Average Links Mediated by Hubs In Shell	23.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	8.25
Average Number Of Links With An Hub	6.42
Average Interaction Strength	9.57
Average Nodes In Shell	24.00
Average Hubs In Shell	14.92
Average Links In Shell	47.25
Average Links Mediated by Hubs In Shell	46.33

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)