CodeDGV
Name1-benzyl-N-{3-[4-(2,6-dichlorophenyl)piperidin-1-yl]propyl}-D-prolinamide
Synonyms
Identifier(2R)-N-[3-[4-[2,6-bis(chloranyl)phenyl]piperidin-1-yl]propyl]-1-(phenylmethyl)pyrrolidine-2-carboxamide
FormulaC26 H33 Cl2 N3 O
Molecular Weight474.466
SMILESc1ccc(cc1)CN2CCC[C@@H]2C(=O)NCCCN3CCC(CC3)c4c(cccc4Cl)Cl
PubChem25001412
Formal Charge0
Total Atoms65
Total Chiral Atoms1
Total Bonds68
Total Aromatic Bonds12
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5DHG A Peptide Opioid NOP Homo sapiens PubChem 25001412 - - 3 2015-10-21 10.1016/j.str.2015.07.024

A 2D representation of the interactions of DGV in 5DHG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L104 R:R:Y58 3.52 1 Yes Yes 7 7 2 2
R:R:Y309 R:R:Y58 4.96 1 Yes Yes 6 7 1 2
R:R:Q107 R:R:T103 5.67 1 No No 5 6 1 2
R:R:T103 R:R:V126 7.93 0 No No 6 5 2 2
R:R:L104 R:R:Y309 8.21 1 Yes Yes 7 6 2 1
R:R:Q107 R:R:Y309 10.15 1 No Yes 5 6 1 1
L:L:?1201 R:R:Q107 9.63 1 Yes No 0 5 0 1
R:R:D110 R:R:W116 8.93 1 No Yes 4 8 1 1
L:L:?1201 R:R:D110 6.25 1 Yes No 0 4 0 1
R:R:F118 R:R:W116 13.03 1 Yes Yes 6 8 2 1
R:R:C123 R:R:W116 3.92 1 No Yes 9 8 2 1
R:R:V126 R:R:W116 3.68 0 No Yes 5 8 2 1
R:R:C200 R:R:W116 5.22 1 No Yes 9 8 2 1
L:L:?1201 R:R:W116 3.75 1 Yes Yes 0 8 0 1
R:R:C123 R:R:C200 7.28 1 No No 9 9 2 2
R:R:C200 R:R:I127 3.27 1 No No 9 4 2 1
L:L:?1201 R:R:I127 13.14 1 Yes No 0 4 0 1
R:R:D130 R:R:Y309 5.75 1 No Yes 6 6 1 1
L:L:?1201 R:R:D130 24.99 1 Yes No 0 6 0 1
R:R:V185 R:R:Y131 7.57 0 No No 4 4 2 1
L:L:?1201 R:R:Y131 16.19 1 Yes No 0 4 0 1
R:R:M134 R:R:W276 16.29 0 No Yes 7 8 1 2
L:L:?1201 R:R:M134 10.23 1 Yes No 0 7 0 1
R:R:F135 R:R:S223 7.93 0 No Yes 6 6 2 1
R:R:F220 R:R:Q280 4.68 0 No Yes 5 7 2 1
R:R:Q280 R:R:S223 4.33 1 Yes Yes 7 6 1 1
L:L:?1201 R:R:S223 4.94 1 Yes Yes 0 6 0 1
R:R:F224 R:R:Q280 21.08 0 No Yes 8 7 2 1
R:R:W276 R:R:Y309 3.86 1 Yes Yes 8 6 2 1
L:L:?1201 R:R:Q280 11.38 1 Yes Yes 0 7 0 1
R:R:T305 R:R:Y309 4.99 0 No Yes 5 6 2 1
L:L:?1201 R:R:Y309 3.86 1 Yes Yes 0 6 0 1
R:R:I219 R:R:S223 3.1 0 No Yes 4 6 2 1
L:L:?1201 R:R:V283 2.94 1 Yes No 0 5 0 1
R:R:Q286 R:R:V283 2.87 0 No No 4 5 2 1
R:R:G119 R:R:W116 2.81 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.75
Average Nodes In Shell28.00
Average Hubs In Shell9.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.75
Average Nodes In Shell28.00
Average Hubs In Shell9.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell30.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)