CodeDHI
NameD-HISTIDINE
Synonyms
Identifier(2R)-2-amino-3-(1H-imidazol-3-ium-4-yl)propanoic acid
FormulaC6 H10 N3 O2
Molecular Weight156.162
SMILESc1c([nH+]c[nH]1)C[C@H](C(=O)O)N
PubChem5288059
Formal Charge1
Total Atoms21
Total Chiral Atoms1
Total Bonds21
Total Aromatic Bonds5
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 10.1038/s41467-021-25364-2

A 2D representation of the interactions of DHI in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 16.25 0 No Yes 0 0 0 1
L:L:?1 R:R:Y106 10.11 0 No No 0 3 0 1
L:L:?1 R:R:R199 5.24 0 No No 0 3 0 1
L:L:?2 L:L:?3 30.44 3 Yes Yes 0 0 1 2
L:L:?2 L:L:?6 9.62 3 Yes Yes 0 0 1 2
L:L:?2 R:R:D99 5.43 3 Yes No 0 6 1 2
L:L:?2 R:R:L103 8.87 3 Yes No 0 4 1 2
L:L:?2 R:R:Q302 11.72 3 Yes No 0 3 1 2
L:L:?2 R:R:F309 9.75 3 Yes Yes 0 5 1 2
L:L:?6 R:R:D99 4.71 3 Yes No 0 6 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 2 2
R:R:E197 R:R:Y106 8.98 0 No No 4 3 2 1
R:R:E185 R:R:R199 20.93 0 No No 1 3 2 1
R:R:E197 R:R:R199 5.82 0 No No 4 3 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.53
Average Nodes In Shell12.00
Average Hubs In Shell4.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell9.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.53
Average Nodes In Shell12.00
Average Hubs In Shell4.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell9.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)