psnGPCR

Code	DI7
Name	2,6-dimethyl-L-tyrosine
Synonyms
Identifier
Formula	C11 H15 N O3
Molecular Weight	209.242
SMILES
PubChem	40580600
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	1
Total Bonds	30
Total Aromatic Bonds	6
Networks	3

This ligand is also present in the following 3 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4RWA

Peptide

Opioid

DOP

Homo Sapiens

DIPP-NH2

3.28

2015-01-14

doi.org/10.1038/nsmb.2965

A 2D representation of the interactions of DI7 in 4RWA
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	43.1	1	Yes	Yes	0	0	0	1
L:L:?1	L:L:F3	3.76	1	Yes	Yes	0	0	0	1
L:L:?1	R:R:D128	14.66	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y129	11.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M132	17.45	1	Yes	No	0	8	0	1
L:L:?1	R:R:K214	6.53	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V217	5.75	1	Yes	No	0	5	0	1
L:L:?1	R:R:I277	5.51	1	Yes	No	0	5	0	1
L:L:?1	R:R:V281	3.45	1	Yes	No	0	6	0	1
L:L:?1	R:R:I304	5.51	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y308	4.52	1	Yes	Yes	0	7	0	1
L:L:?2	L:L:F3	14.64	1	Yes	Yes	0	0	1	1
L:L:?2	R:R:K214	4.84	1	Yes	Yes	0	5	1	1
L:L:?2	R:R:V281	14.07	1	Yes	No	0	6	1	1
L:L:?2	R:R:W284	7.82	1	Yes	No	0	4	1	2
L:L:?2	R:R:L300	3.57	1	Yes	Yes	0	5	1	2
L:L:?2	R:R:I304	3.68	1	Yes	Yes	0	5	1	1
L:L:F3	R:R:L125	14.61	1	Yes	Yes	0	5	1	2
L:L:F3	R:R:D128	8.36	1	Yes	No	0	5	1	1
R:R:L102	R:R:Y56	11.72	1	No	Yes	7	7	2	2
R:R:Q105	R:R:Y56	3.38	1	No	Yes	5	7	2	2
R:R:Y308	R:R:Y56	4.96	1	Yes	Yes	7	7	1	2
R:R:L102	R:R:Y308	8.21	1	No	Yes	7	7	2	1
R:R:Q105	R:R:Y308	6.76	1	No	Yes	5	7	2	1
R:R:L125	R:R:L200	4.15	0	Yes	No	5	4	2	2
R:R:D128	R:R:Y308	9.2	1	No	Yes	5	7	1	1
R:R:M132	R:R:Y129	3.59	1	No	Yes	8	5	1	1
R:R:I183	R:R:Y129	6.04	0	No	Yes	4	5	2	1
R:R:L200	R:R:Y129	3.52	0	No	Yes	4	5	2	1
R:R:M132	R:R:W274	3.49	1	No	Yes	8	8	1	2
R:R:D210	R:R:K214	4.15	0	No	Yes	4	5	2	1
R:R:K214	R:R:T285	7.51	1	Yes	No	5	4	1	2
R:R:F222	R:R:H278	18.1	0	No	No	8	7	2	1
R:R:I277	R:R:I304	5.89	1	No	Yes	5	5	1	1
R:R:L300	R:R:W284	4.56	1	Yes	No	5	4	2	2
R:R:I304	R:R:L300	4.28	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:H278	2.98	1	Yes	No	0	7	0	1

Statistics	Value
Average Number Of Links	12.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	10.42
Average Nodes In Shell	25.00
Average Hubs In Shell	11.00
Average Links In Shell	37.00
Average Links Mediated by Hubs In Shell	36.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

4RWD

Peptide

Opioid

DOP

Homo Sapiens

DIPP-NH2

2.7

2015-01-14

doi.org/10.1038/nsmb.2965

A 2D representation of the interactions of DI7 in 4RWD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	37.6	1	Yes	Yes	0	0	0	1
L:L:?1	L:L:F3	5.64	1	Yes	Yes	0	0	0	1
L:L:?1	R:R:D128	10.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y129	9.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	16.36	1	Yes	No	0	8	0	1
L:L:?1	R:R:V217	8.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:I277	6.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:H278	5.95	1	Yes	No	0	7	0	1
L:L:?1	R:R:V281	6.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:I304	6.61	1	Yes	No	0	5	0	1
L:L:?2	L:L:F3	12.55	1	Yes	Yes	0	0	1	1
L:L:?2	R:R:V281	15.35	1	Yes	No	0	6	1	1
L:L:?2	R:R:W284	7.82	1	Yes	No	0	4	1	2
L:L:?2	R:R:L300	5.94	1	Yes	No	0	5	1	2
L:L:?2	R:R:I304	3.68	1	Yes	No	0	5	1	1
L:L:F3	R:R:L125	7.31	1	Yes	No	0	5	1	2
L:L:F3	R:R:D128	9.55	1	Yes	No	0	5	1	1
R:R:D128	R:R:Y308	9.2	1	No	Yes	5	7	1	2
R:R:V179	R:R:Y129	3.79	0	No	No	4	5	2	1
R:R:I183	R:R:Y129	20.55	0	No	No	4	5	2	1
R:R:M132	R:R:W274	5.82	0	No	Yes	8	8	1	2
R:R:F222	R:R:H278	6.79	0	No	No	8	7	2	1
R:R:L300	R:R:W284	4.56	1	No	No	5	4	2	2
R:R:F218	R:R:H278	3.39	0	No	No	5	7	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	2.00
Average Interaction Strength	11.41
Average Nodes In Shell	20.00
Average Hubs In Shell	5.00
Average Links In Shell	24.00
Average Links Mediated by Hubs In Shell	19.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

6PT2

Peptide

Opioid

DOP

Homo Sapiens

KGCHM07

2.8

2019-12-11

doi.org/10.1126/sciadv.aax9115

A 2D representation of the interactions of DI7 in 6PT2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	L:L:?2	23	1	Yes	Yes	0	0	0	1
L:L:?1	R:R:D128	10.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y129	10.86	1	Yes	No	0	5	0	1
L:L:?1	R:R:M132	10.91	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V217	8.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:W274	3.52	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:I277	5.51	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H278	5.95	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I304	3.3	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y308	4.52	1	Yes	Yes	0	7	0	1
L:L:?2	L:L:?4	17.11	1	Yes	No	0	0	1	2
L:L:?2	L:L:?5	12.45	1	Yes	Yes	0	0	1	2
L:L:?2	R:R:K214	3.37	1	Yes	Yes	0	5	1	2
L:L:?2	R:R:V281	3.56	1	Yes	Yes	0	6	1	2
L:L:?2	R:R:W284	3.63	1	Yes	No	0	4	1	2
L:L:?2	R:R:I304	3.41	1	Yes	Yes	0	5	1	1
L:L:?4	L:L:?5	15.19	1	No	Yes	0	0	2	2
L:L:?5	R:R:V281	6.92	1	Yes	Yes	0	6	2	2
L:L:?5	R:R:W284	49.14	1	Yes	No	0	4	2	2
L:L:?5	R:R:L300	16.54	1	Yes	No	0	5	2	2
R:R:L102	R:R:Y56	3.52	0	Yes	Yes	7	7	2	2
R:R:I304	R:R:Y56	7.25	1	Yes	Yes	5	7	1	2
R:R:L102	R:R:Y308	14.07	0	Yes	Yes	7	7	2	1
R:R:Q105	R:R:Y308	4.51	0	No	Yes	5	7	2	1
R:R:D128	R:R:Y308	6.9	1	No	Yes	5	7	1	1
R:R:I183	R:R:Y129	21.76	1	No	No	4	5	2	1
R:R:L200	R:R:Y129	3.52	1	Yes	No	4	5	2	1
R:R:F133	R:R:M132	3.73	1	Yes	Yes	7	8	2	1
R:R:I136	R:R:M132	2.92	1	Yes	Yes	7	8	2	1
R:R:M132	R:R:V217	3.04	1	Yes	No	8	5	1	1
R:R:M132	R:R:W274	3.49	1	Yes	Yes	8	8	1	1
R:R:F133	R:R:V217	5.24	1	Yes	No	7	5	2	1
R:R:F270	R:R:I136	8.79	1	Yes	Yes	9	7	2	2
R:R:I136	R:R:W274	3.52	1	Yes	Yes	7	8	2	1
R:R:I183	R:R:L200	5.71	1	No	Yes	4	4	2	2
R:R:K214	R:R:V281	4.55	1	Yes	Yes	5	6	2	2
R:R:K214	R:R:W284	3.48	1	Yes	No	5	4	2	2
R:R:F218	R:R:F222	9.65	1	Yes	Yes	5	8	2	2
R:R:F218	R:R:H278	9.05	1	Yes	Yes	5	7	2	1
R:R:F222	R:R:H278	7.92	1	Yes	Yes	8	7	2	1
R:R:F270	R:R:W274	9.02	1	Yes	Yes	9	8	2	1
R:R:F270	R:R:N310	3.62	1	Yes	Yes	9	9	2	2
R:R:H278	R:R:W274	4.23	1	Yes	Yes	7	8	1	1
R:R:G307	R:R:W274	8.44	0	No	Yes	7	8	2	1
R:R:N310	R:R:W274	6.78	1	Yes	Yes	9	8	2	1
R:R:I277	R:R:V281	3.07	1	Yes	Yes	5	6	1	2
R:R:C303	R:R:I277	3.27	0	No	Yes	6	5	2	1
R:R:I277	R:R:I304	2.94	1	Yes	Yes	5	5	1	1
R:R:I304	R:R:L300	5.71	1	Yes	No	5	5	1	2
R:R:A98	R:R:Y308	2.67	0	No	Yes	6	7	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.61
Average Nodes In Shell	31.00
Average Hubs In Shell	20.00
Average Links In Shell	50.00
Average Links Mediated by Hubs In Shell	49.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	10.67
Average Number Of Links With An Hub	5.00
Average Interaction Strength	10.15
Average Nodes In Shell	25.33
Average Hubs In Shell	12.00
Average Links In Shell	37.00
Average Links Mediated by Hubs In Shell	34.67

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)