CodeDI7
Name2,6-dimethyl-L-tyrosine
Synonyms
Identifier(2S)-2-azanyl-3-(2,6-dimethyl-4-oxidanyl-phenyl)propanoic acid
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCc1cc(cc(c1C[C@@H](C(=O)O)N)C)O
PubChem124247
Formal Charge0
Total Atoms30
Total Chiral Atoms1
Total Bonds30
Total Aromatic Bonds6
Networks3
 missing image

This ligand is also present in the following 3 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4RWA A Peptide Opioid DOP Homo sapiens DIPP-NH2 - - 3.28 2015-01-14 10.1038/nsmb.2965

A 2D representation of the interactions of DI7 in 4RWA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L102 R:R:Y56 11.72 1 No Yes 7 7 2 2
R:R:Y308 R:R:Y56 4.96 1 Yes Yes 7 7 1 2
R:R:L102 R:R:Y308 8.21 1 No Yes 7 7 2 1
R:R:Q105 R:R:Y308 6.76 0 No Yes 5 7 2 1
R:R:L125 R:R:L200 4.15 0 Yes No 5 4 2 2
L:L:F3 R:R:L125 14.61 1 Yes Yes 0 5 1 2
R:R:D128 R:R:Y308 9.2 1 No Yes 5 7 1 1
L:L:?1 R:R:D128 14.66 1 Yes No 0 5 0 1
L:L:F3 R:R:D128 8.36 1 Yes No 0 5 1 1
R:R:M132 R:R:Y129 3.59 1 No Yes 8 5 1 1
R:R:I183 R:R:Y129 6.04 0 No Yes 4 5 2 1
R:R:L200 R:R:Y129 3.52 0 No Yes 4 5 2 1
L:L:?1 R:R:Y129 11.76 1 Yes Yes 0 5 0 1
R:R:M132 R:R:W274 3.49 1 No Yes 8 8 1 2
L:L:?1 R:R:M132 17.45 1 Yes No 0 8 0 1
L:L:?1 R:R:V217 5.75 1 Yes No 0 5 0 1
R:R:F222 R:R:H278 18.1 0 No No 8 7 2 1
R:R:I277 R:R:I304 5.89 1 No Yes 5 5 1 1
L:L:?1 R:R:I277 5.51 1 Yes No 0 5 0 1
L:L:?1 R:R:V281 3.45 1 Yes No 0 6 0 1
L:L:?2 R:R:V281 14.07 1 Yes No 0 6 1 1
R:R:L300 R:R:W284 4.56 1 Yes No 5 4 2 2
L:L:?2 R:R:W284 7.82 1 Yes No 0 4 1 2
R:R:I304 R:R:L300 4.28 1 Yes Yes 5 5 1 2
L:L:?2 R:R:L300 3.57 1 Yes Yes 0 5 1 2
L:L:?1 R:R:I304 5.51 1 Yes Yes 0 5 0 1
L:L:?2 R:R:I304 3.68 1 Yes Yes 0 5 1 1
L:L:?1 R:R:Y308 4.52 1 Yes Yes 0 7 0 1
L:L:?1 L:L:?2 43.1 1 Yes Yes 0 0 0 1
L:L:?1 L:L:F3 3.76 1 Yes Yes 0 0 0 1
L:L:?2 L:L:F3 14.64 1 Yes Yes 0 0 1 1
L:L:?1 R:R:H278 2.98 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.77
Average Nodes In Shell22.00
Average Hubs In Shell10.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4RWD A Peptide Opioid DOP Homo sapiens DIPP-NH2 Na - 2.7 2015-01-14 10.1038/nsmb.2965

A 2D representation of the interactions of DI7 in 4RWD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F3 R:R:L125 7.31 1 Yes No 0 5 1 2
R:R:D128 R:R:Y308 9.2 1 No Yes 5 7 1 2
L:L:?1 R:R:D128 10.47 1 Yes No 0 5 0 1
L:L:F3 R:R:D128 9.55 1 Yes No 0 5 1 1
R:R:V179 R:R:Y129 3.79 0 No No 4 5 2 1
R:R:I183 R:R:Y129 20.55 0 No No 4 5 2 1
L:L:?1 R:R:Y129 9.95 1 Yes No 0 5 0 1
R:R:M132 R:R:W274 5.82 0 No Yes 8 8 1 2
L:L:?1 R:R:M132 16.36 1 Yes No 0 8 0 1
L:L:?1 R:R:V217 8.05 1 Yes No 0 5 0 1
R:R:F222 R:R:H278 6.79 0 No No 8 7 2 1
L:L:?1 R:R:I277 6.61 1 Yes No 0 5 0 1
L:L:?1 R:R:H278 5.95 1 Yes No 0 7 0 1
L:L:?1 R:R:V281 6.9 1 Yes No 0 6 0 1
L:L:?2 R:R:V281 15.35 1 Yes No 0 6 1 1
R:R:L300 R:R:W284 4.56 1 No No 5 4 2 2
L:L:?2 R:R:W284 7.82 1 Yes No 0 4 1 2
L:L:?2 R:R:L300 5.94 1 Yes No 0 5 1 2
L:L:?1 R:R:I304 6.61 1 Yes No 0 5 0 1
L:L:?1 L:L:?2 37.6 1 Yes Yes 0 0 0 1
L:L:?1 L:L:F3 5.64 1 Yes Yes 0 0 0 1
L:L:?2 L:L:F3 12.55 1 Yes Yes 0 0 1 1
R:R:F218 R:R:H278 3.39 0 No No 5 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength11.41
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6PT2 A Peptide Opioid DOP Homo sapiens KGCHM07 - - 2.8 2019-12-11 10.1126/sciadv.aax9115

A 2D representation of the interactions of DI7 in 6PT2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L102 R:R:Y56 3.52 0 Yes Yes 7 7 2 2
R:R:I304 R:R:Y56 7.25 1 Yes Yes 5 7 1 2
R:R:L102 R:R:Y308 14.07 0 Yes Yes 7 7 2 1
R:R:Q105 R:R:Y308 4.51 0 No Yes 5 7 2 1
R:R:D128 R:R:Y308 6.9 1 No Yes 5 7 1 1
L:L:?1 R:R:D128 10.47 1 Yes No 0 5 0 1
R:R:I183 R:R:Y129 21.76 1 No No 4 5 2 1
R:R:L200 R:R:Y129 3.52 1 Yes No 4 5 2 1
L:L:?1 R:R:Y129 10.86 1 Yes No 0 5 0 1
R:R:F133 R:R:M132 3.73 1 Yes Yes 7 8 2 1
R:R:I136 R:R:M132 2.92 1 Yes Yes 7 8 2 1
R:R:M132 R:R:V217 3.04 1 Yes No 8 5 1 1
R:R:M132 R:R:W274 3.49 1 Yes Yes 8 8 1 1
L:L:?1 R:R:M132 10.91 1 Yes Yes 0 8 0 1
R:R:F133 R:R:V217 5.24 1 Yes No 7 5 2 1
R:R:F270 R:R:I136 8.79 1 Yes Yes 9 7 2 2
R:R:I136 R:R:W274 3.52 1 Yes Yes 7 8 2 1
R:R:I183 R:R:L200 5.71 1 No Yes 4 4 2 2
R:R:K214 R:R:V281 4.55 1 Yes Yes 5 6 2 2
R:R:K214 R:R:W284 3.48 1 Yes No 5 4 2 2
L:L:?2 R:R:K214 3.38 1 Yes Yes 0 5 1 2
L:L:?1 R:R:V217 8.05 1 Yes No 0 5 0 1
R:R:F218 R:R:F222 9.65 1 Yes Yes 5 8 2 2
R:R:F218 R:R:H278 9.05 1 Yes Yes 5 7 2 1
R:R:F222 R:R:H278 7.92 1 Yes Yes 8 7 2 1
R:R:F270 R:R:W274 9.02 1 Yes Yes 9 8 2 1
R:R:F270 R:R:N310 3.62 1 Yes Yes 9 9 2 2
R:R:H278 R:R:W274 4.23 1 Yes Yes 7 8 1 1
R:R:G307 R:R:W274 8.44 0 No Yes 7 8 2 1
R:R:N310 R:R:W274 6.78 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W274 3.52 1 Yes Yes 0 8 0 1
R:R:I277 R:R:V281 3.07 1 Yes Yes 5 6 1 2
R:R:C303 R:R:I277 3.27 0 No Yes 6 5 2 1
R:R:I277 R:R:I304 2.94 1 Yes Yes 5 5 1 1
L:L:?1 R:R:I277 5.51 1 Yes Yes 0 5 0 1
L:L:?1 R:R:H278 5.95 1 Yes Yes 0 7 0 1
L:L:?2 R:R:V281 3.57 1 Yes Yes 0 6 1 2
L:L:?5 R:R:V281 6.92 1 Yes Yes 0 6 2 2
L:L:?2 R:R:W284 3.64 1 Yes No 0 4 1 2
L:L:?5 R:R:W284 49.14 1 Yes No 0 4 2 2
R:R:I304 R:R:L300 5.71 1 Yes No 5 5 1 2
L:L:?5 R:R:L300 16.54 1 Yes No 0 5 2 2
L:L:?1 R:R:I304 3.3 1 Yes Yes 0 5 0 1
L:L:?2 R:R:I304 3.42 1 Yes Yes 0 5 1 1
L:L:?1 R:R:Y308 4.52 1 Yes Yes 0 7 0 1
L:L:?1 L:L:?2 23.05 1 Yes Yes 0 0 0 1
L:L:?2 L:L:?4 17.2 1 Yes No 0 0 1 2
L:L:?2 L:L:?5 12.49 1 Yes Yes 0 0 1 2
L:L:?4 L:L:?5 15.23 1 No Yes 0 0 2 2
R:R:A98 R:R:Y308 2.67 0 No Yes 6 7 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.61
Average Nodes In Shell31.00
Average Hubs In Shell20.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.33
Average Number Of Links With An Hub4.67
Average Interaction Strength10.27
Average Nodes In Shell24.33
Average Hubs In Shell11.67
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell32.67

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)