CodeDPR
NameD-Proline
SynonymsD-Proline
Identifier(2R)-pyrrolidine-2-carboxylic acid
FormulaC5 H9 N O2
Molecular Weight115.13
SMILESC1C[C@@H](NC1)C(=O)O
PubChem6971012
Formal Charge0
Total Atoms17
Total Chiral Atoms1
Total Bonds17
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3OE0 A Protein Chemokine CXCR4 Homo sapiens - CVX15 - 2.9 2010-10-27 10.1126/science.1194396

A 2D representation of the interactions of DPR in 3OE0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F189 W:W:Q6 5.86 0 No No 3 0 2 1
R:R:D193 W:W:K7 5.53 8 No No 1 0 2 1
W:W:?8 W:W:Q6 7.84 0 No No 0 0 0 1
W:W:?8 W:W:K7 4.15 0 No No 0 0 0 1
W:W:?8 W:W:P9 14.51 0 No No 0 0 0 1
W:W:P9 W:W:Y10 9.74 0 No No 0 0 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength8.83
Average Nodes In Shell7.00
Average Hubs In Shell0.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DPR in 3OE0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F36 R:R:S285 6.61 2 Yes No 4 5 2 1
R:R:W94 R:R:Y116 3.86 1 Yes Yes 7 6 2 2
R:R:E288 R:R:W94 4.36 1 Yes Yes 5 7 1 2
R:R:E288 R:R:Y116 5.61 1 Yes Yes 5 6 1 2
R:R:F292 R:R:Y116 5.16 1 Yes Yes 7 6 2 2
R:R:D187 W:W:R1 10.72 0 No Yes 3 0 2 1
R:R:I259 R:R:Y255 8.46 1 Yes Yes 5 7 2 2
R:R:E288 R:R:Y255 7.86 1 Yes Yes 5 7 1 2
R:R:G258 R:R:I284 3.53 0 No Yes 4 4 2 1
R:R:I259 R:R:I284 4.42 1 Yes Yes 5 4 2 1
R:R:D262 R:R:H281 5.04 1 Yes Yes 5 4 2 2
R:R:D262 R:R:I284 4.2 1 Yes Yes 5 4 2 1
R:R:H281 W:W:G15 4.77 0 Yes No 4 0 2 1
R:R:I284 W:W:?16 5.61 0 Yes Yes 4 0 1 0
R:R:S285 W:W:?16 5.9 0 No Yes 5 0 1 0
R:R:E288 R:R:F292 5.83 1 Yes Yes 5 7 1 2
R:R:E288 W:W:?16 6.51 1 Yes Yes 5 0 1 0
W:W:C13 W:W:R1 8.36 1 No Yes 0 0 2 1
W:W:?16 W:W:R1 3.58 0 Yes Yes 0 0 0 1
W:W:?16 W:W:G15 10.08 0 Yes No 0 0 0 1
R:R:E32 W:W:R1 2.33 0 No Yes 4 0 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.34
Average Nodes In Shell18.00
Average Hubs In Shell12.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub1.50
Average Interaction Strength7.58
Average Nodes In Shell12.50
Average Hubs In Shell6.00
Average Links In Shell13.50
Average Links Mediated by Hubs In Shell10.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)