CodeDTH
NameD-THREONINE
Synonyms
Identifier(2R,3S)-2-amino-3-hydroxy-butanoic acid
FormulaC4 H9 N O3
Molecular Weight119.119
SMILESC[C@@H]([C@H](C(=O)O)N)O
PubChem6995277
Formal Charge0
Total Atoms17
Total Chiral Atoms2
Total Bonds16
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FEG A Peptide Opioid KOP Homo Sapiens PRD_002517 - Gi1/Beta1/Gamma2 2.54 2023-12-06 10.1038/s41467-023-43718-w

A 2D representation of the interactions of DTH in 8FEG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E209 R:R:K200 6.75 1 Yes No 3 2 1 2
R:R:E209 R:R:R202 13.96 1 Yes Yes 3 2 1 1
L:L:?4 R:R:R202 4.86 1 Yes Yes 0 2 1 1
L:L:?5 R:R:R202 3.38 1 Yes Yes 0 2 0 1
R:R:E209 R:R:S211 4.31 1 Yes No 3 4 1 2
L:L:?5 R:R:E209 3.69 1 Yes Yes 0 3 0 1
L:L:T6 R:R:E209 5.64 1 No Yes 0 3 1 1
L:L:?4 R:R:T302 8.26 1 Yes No 0 1 1 2
L:L:Y2 R:R:S305 7.63 1 Yes No 0 3 2 2
L:L:?4 R:R:S305 6.01 1 Yes No 0 3 1 2
L:L:?1 R:R:L309 14.54 1 Yes No 0 4 1 2
L:L:Y2 R:R:L309 7.03 1 Yes No 0 4 2 2
L:L:?1 R:R:Y312 12.32 1 Yes Yes 0 4 1 2
L:L:?1 L:L:Y2 12.32 1 Yes Yes 0 0 1 2
L:L:?1 L:L:?5 5.78 1 Yes Yes 0 0 1 0
L:L:?1 L:L:C7 11.91 1 Yes No 0 0 1 1
L:L:A3 L:L:Y2 8.01 1 No Yes 0 0 2 2
L:L:?4 L:L:Y2 14.08 1 Yes Yes 0 0 1 2
L:L:?4 L:L:A3 10.09 1 Yes No 0 0 1 2
L:L:?4 L:L:?5 23.66 1 Yes Yes 0 0 1 0
L:L:?5 L:L:T6 10.94 1 Yes No 0 0 0 1
L:L:?5 L:L:C7 8.84 1 Yes No 0 0 0 1
R:R:R202 R:R:V207 2.62 1 Yes No 2 3 1 2
L:L:?5 R:R:N122 1.27 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.22
Average Nodes In Shell17.00
Average Hubs In Shell7.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.22
Average Nodes In Shell17.00
Average Hubs In Shell7.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell24.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)