CodeDTH
NameD-THREONINE
Synonyms
Identifier
FormulaC4 H9 N O3
Molecular Weight119.119
SMILES
PubChem6995277
Formal Charge0
Total Atoms17
Total Chiral Atoms2
Total Bonds16
Total Aromatic Bonds0
Networks4
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This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FEG A Peptide Opioid KOP Homo Sapiens (DNCP)-Beta-Naloxamine - Gi1/Beta1/Gamma2 2.54 2023-12-06 doi.org/10.1038/s41467-023-43718-w

A 2D representation of the interactions of DTH in 8FEG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:Y2 12.29 3 Yes Yes 0 0 1 2
L:L:?1 L:L:?5 5.74 3 Yes Yes 0 0 1 0
L:L:?1 L:L:C7 11.88 3 Yes Yes 0 0 1 1
L:L:?1 R:R:L309 14.51 3 Yes No 0 4 1 2
L:L:?1 R:R:Y312 12.29 3 Yes Yes 0 4 1 2
L:L:A3 L:L:Y2 8.01 3 No Yes 0 0 2 2
L:L:?4 L:L:Y2 14.06 3 Yes Yes 0 0 1 2
L:L:Y2 R:R:S305 7.63 3 Yes No 0 3 2 2
L:L:Y2 R:R:L309 5.86 3 Yes No 0 4 2 2
L:L:?4 L:L:A3 10.08 3 Yes No 0 0 1 2
L:L:?4 L:L:?5 23.5 3 Yes Yes 0 0 1 0
L:L:?4 R:R:R202 21.37 3 Yes No 0 2 1 1
L:L:?4 R:R:T302 8.25 3 Yes No 0 1 1 2
L:L:?4 R:R:S305 6 3 Yes No 0 3 1 2
L:L:?5 L:L:T6 10.89 3 Yes No 0 0 0 1
L:L:?5 L:L:C7 8.79 3 Yes Yes 0 0 0 1
L:L:?5 R:R:R202 15.7 3 Yes No 0 2 0 1
L:L:?5 R:R:E209 4.89 3 Yes Yes 0 3 0 1
L:L:T6 R:R:E209 7.06 3 No Yes 0 3 1 1
L:L:?9 L:L:C7 2.69 3 Yes Yes 0 0 2 1
L:L:C7 R:R:Y312 5.38 3 Yes Yes 0 4 1 2
R:R:E209 R:R:K200 6.75 3 Yes No 3 2 1 2
R:R:R202 R:R:V207 3.92 3 No No 2 3 1 2
R:R:E209 R:R:S211 7.19 3 Yes No 3 4 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.59
Average Nodes In Shell17.00
Average Hubs In Shell8.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XGO A Peptide Kisspeptin Kiss1 Homo Sapiens TAK448 - chim(NtGi1-Gq)/Beta1/Gamma2 2.68 2024-10-30 doi.org/10.1126/sciadv.adn7771

A 2D representation of the interactions of DTH in 8XGO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F49 R:R:V45 3.93 3 Yes Yes 7 5 2 2
R:R:V45 R:R:Y103 12.62 3 Yes Yes 5 5 2 1
R:R:F49 R:R:Y103 4.13 3 Yes Yes 7 5 2 1
L:L:N4 R:R:L102 6.87 3 Yes No 0 5 1 1
L:L:?5 R:R:L102 5.11 3 Yes No 0 5 0 1
L:L:?7 R:R:L102 5.35 0 No No 0 5 2 1
R:R:Y103 R:R:Y302 7.94 3 Yes Yes 5 5 1 2
R:R:T306 R:R:Y103 4.99 3 No Yes 4 5 2 1
L:L:?5 R:R:Y103 8.66 3 Yes Yes 0 5 0 1
L:L:N4 R:R:G107 5.09 3 Yes No 0 5 1 2
L:L:?3 R:R:Y190 8.05 3 Yes Yes 0 4 1 2
L:L:N4 R:R:Y190 4.65 3 Yes Yes 0 4 1 2
R:R:F282 R:R:K305 12.41 0 No No 5 4 2 1
L:L:F6 R:R:F282 4.29 3 Yes No 0 5 1 2
L:L:F6 R:R:R297 17.1 3 Yes No 0 2 1 2
R:R:T306 R:R:Y302 6.24 3 No Yes 4 5 2 2
L:L:Y2 R:R:Y302 3.97 0 No Yes 0 5 2 2
R:R:H309 R:R:K305 11.79 6 Yes No 6 4 2 1
L:L:?5 R:R:K305 9.11 3 Yes No 0 4 0 1
L:L:?3 L:L:Y2 11.07 3 Yes No 0 0 1 2
L:L:?3 L:L:N4 8.25 3 Yes Yes 0 0 1 1
L:L:?3 L:L:?5 15.36 3 Yes Yes 0 0 1 0
L:L:?3 L:L:F6 4.18 3 Yes Yes 0 0 1 1
L:L:?5 L:L:N4 8.87 3 Yes Yes 0 0 0 1
L:L:?5 L:L:F6 15.74 3 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.47
Average Nodes In Shell18.00
Average Hubs In Shell10.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.75
Average Interaction Strength11.03
Average Nodes In Shell17.25
Average Hubs In Shell8.50
Average Links In Shell24.25
Average Links Mediated by Hubs In Shell22.75

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)