| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7BU6 | A | Amine | Adrenergic | Beta1 | Homo Sapiens | L-Norepinephrine | - | - | 2.7 | 2020-12-02 | 10.1038/s41422-020-00424-2 |
|
A 2D representation of the interactions of E5E in 7BU6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D138 | 17.31 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V139 | 17.65 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V142 | 8.15 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F218 | 16.65 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S228 | 9.58 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:S232 | 8.21 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F340 | 9.99 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F341 | 7.77 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N344 | 5.01 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:N363 | 15.02 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:Y367 | 3.2 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:M107 | R:R:V111 | 7.61 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | | R:R:M107 | R:R:Y367 | 3.59 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:D138 | R:R:V111 | 7.3 | 1 | No | Yes | 7 | 7 | 1 | 2 | | R:R:V111 | R:R:Y367 | 3.79 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:V112 | R:R:Y367 | 5.05 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:D138 | R:R:Y367 | 10.34 | 1 | No | Yes | 7 | 8 | 1 | 1 | | R:R:S190 | R:R:V139 | 3.23 | 5 | No | No | 7 | 7 | 2 | 1 | | R:R:V139 | R:R:Y224 | 3.79 | 0 | No | Yes | 7 | 7 | 1 | 2 | | R:R:V142 | R:R:W337 | 9.81 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:S232 | R:R:T143 | 9.59 | 0 | No | Yes | 7 | 7 | 1 | 2 | | R:R:F218 | R:R:N344 | 4.83 | 1 | No | Yes | 6 | 6 | 1 | 1 | | R:R:F218 | R:R:F359 | 3.22 | 1 | No | Yes | 6 | 5 | 1 | 2 | | R:R:S228 | R:R:Y224 | 11.45 | 0 | No | Yes | 6 | 7 | 1 | 2 | | R:R:S229 | R:R:Y234 | 3.82 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F341 | R:R:S229 | 5.28 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:N344 | R:R:S229 | 4.47 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | | R:R:F233 | R:R:Y234 | 9.28 | 1 | Yes | Yes | 8 | 5 | 2 | 2 | | R:R:F233 | R:R:F341 | 21.43 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F341 | R:R:Y234 | 3.09 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | | R:R:F340 | R:R:W337 | 5.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F341 | R:R:W337 | 10.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F340 | R:R:F341 | 11.79 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:F340 | R:R:N344 | 8.46 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | | R:R:F340 | R:R:F359 | 7.5 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | | R:R:F340 | R:R:N363 | 15.71 | 1 | Yes | No | 7 | 6 | 1 | 1 | | R:R:F359 | R:R:N344 | 3.62 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | | R:R:N363 | R:R:Y367 | 11.63 | 1 | No | Yes | 6 | 8 | 1 | 1 | | R:R:W364 | R:R:Y367 | 15.43 | 1 | Yes | Yes | 7 | 8 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 10.78 | | Average Nodes In Shell | 24.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 39.00 | | Average Links Mediated by Hubs In Shell | 38.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7EJ0 | A | Amine | Adrenergic | Alpha2A | Homo Sapiens | L-Norepinephrine | - | Go/Beta1/Gamma2 | 3.2 | 2022-04-13 | 10.1126/sciadv.abj5347 |
|
A 2D representation of the interactions of E5E in 7EJ0
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D128 | R:R:V101 | 8.76 | 2 | No | Yes | 8 | 8 | 1 | 2 | | R:R:V101 | R:R:Y431 | 6.31 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:D128 | R:R:Y431 | 5.75 | 2 | No | Yes | 8 | 8 | 1 | 1 | | L:L:?1 | R:R:D128 | 9.89 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:S180 | R:R:V129 | 8.08 | 0 | No | No | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:V129 | 12.22 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:C132 | R:R:W402 | 3.92 | 0 | No | Yes | 7 | 9 | 1 | 2 | | L:L:?1 | R:R:C132 | 11.57 | 2 | Yes | No | 0 | 7 | 0 | 1 | | R:R:S219 | R:R:T133 | 4.8 | 0 | No | No | 8 | 8 | 1 | 2 | | R:R:I205 | R:R:Y409 | 2.42 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:V212 | R:R:Y409 | 10.09 | 0 | No | Yes | 7 | 8 | 2 | 1 | | L:L:?1 | R:R:S215 | 4.1 | 2 | Yes | No | 0 | 9 | 0 | 1 | | R:R:C216 | R:R:F406 | 8.38 | 0 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:C216 | R:R:Y409 | 2.69 | 0 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:F406 | R:R:S219 | 5.28 | 2 | Yes | No | 8 | 8 | 2 | 1 | | L:L:?1 | R:R:S219 | 5.47 | 2 | Yes | No | 0 | 8 | 0 | 1 | | R:R:F406 | R:R:W402 | 8.02 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:F405 | R:R:F406 | 2.14 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | | R:R:F405 | R:R:Y409 | 6.19 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | | R:R:F405 | R:R:F426 | 3.22 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:F405 | R:R:F427 | 7.5 | 2 | Yes | No | 8 | 7 | 1 | 1 | | L:L:?1 | R:R:F405 | 3.33 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:Y409 | 4.27 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:F427 | 3.33 | 2 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:Y431 | 4.27 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | R:R:W428 | R:R:Y431 | 1.93 | 2 | Yes | Yes | 7 | 8 | 2 | 1 | | R:R:A126 | R:R:V129 | 1.7 | 0 | No | No | 8 | 8 | 2 | 1 | | R:R:I179 | R:R:S215 | 1.55 | 0 | No | No | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 6.49 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 10.00 | | Average Links In Shell | 28.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YMH | A | Amine | Adrenergic | Alpha1A | Homo Sapiens | Norepinephrine | - | chim(Gs-CtGq) | 3.52 | 2023-07-05 | 10.1038/s41467-023-39310-x |
|
A 2D representation of the interactions of E5E in 7YMH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D106 | 12.59 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V107 | 12.44 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:C110 | 5.89 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:I178 | 5.3 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F288 | 21.47 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F289 | 5.65 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:F312 | 11.3 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:Y316 | 4.35 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | R:R:L75 | R:R:V79 | 4.47 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:C110 | R:R:L75 | 3.17 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:L75 | R:R:Y316 | 7.03 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D106 | R:R:V79 | 7.3 | 1 | No | Yes | 7 | 8 | 1 | 2 | | R:R:V79 | R:R:Y316 | 3.79 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:L80 | R:R:W313 | 3.42 | 1 | Yes | Yes | 8 | 6 | 2 | 2 | | R:R:L80 | R:R:Y316 | 11.72 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:S83 | R:R:W313 | 4.94 | 1 | No | Yes | 7 | 6 | 2 | 2 | | R:R:S83 | R:R:Y316 | 5.09 | 1 | No | Yes | 7 | 7 | 2 | 1 | | R:R:D106 | R:R:Y316 | 11.49 | 1 | No | Yes | 7 | 7 | 1 | 1 | | R:R:S158 | R:R:V107 | 3.23 | 0 | Yes | No | 8 | 6 | 2 | 1 | | R:R:C110 | R:R:W285 | 7.84 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:E180 | R:R:I178 | 4.1 | 0 | No | No | 5 | 6 | 2 | 1 | | R:R:F312 | R:R:I178 | 3.77 | 1 | No | No | 6 | 6 | 1 | 1 | | R:R:E180 | R:R:M292 | 5.41 | 0 | No | Yes | 5 | 7 | 2 | 2 | | R:R:F193 | R:R:F289 | 18.22 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F289 | R:R:W285 | 4.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F288 | R:R:F289 | 7.5 | 1 | No | Yes | 7 | 7 | 1 | 1 | | R:R:F288 | R:R:M292 | 7.46 | 1 | No | Yes | 7 | 7 | 1 | 2 | | R:R:F312 | R:R:Y316 | 8.25 | 1 | No | Yes | 6 | 7 | 1 | 1 | | R:R:W313 | R:R:Y316 | 5.79 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | | L:L:?1 | R:R:S188 | 2.79 | 1 | Yes | No | 0 | 7 | 0 | 1 | | R:R:A189 | R:R:F289 | 2.77 | 0 | No | Yes | 7 | 7 | 2 | 1 | | R:R:S188 | R:R:Y184 | 2.54 | 0 | No | Yes | 7 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 9.09 | | Average Nodes In Shell | 22.00 | | Average Hubs In Shell | 12.00 | | Average Links In Shell | 32.00 | | Average Links Mediated by Hubs In Shell | 30.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9CHU | A | Amine | Adrenergic | Beta2 | Homo Sapiens | Noradrenaline | - | - | 3.49 | 2024-11-13 | 10.1073/pnas.2414544121 |
|
A 2D representation of the interactions of E5E in 9CHU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:D113 | 13.85 | 1 | Yes | No | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:V114 | 4.15 | 1 | Yes | No | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:V117 | 8.29 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F289 | 7.91 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:F290 | 9.04 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:N312 | 15.29 | 1 | Yes | No | 0 | 5 | 0 | 1 | | R:R:D113 | R:R:V86 | 4.38 | 1 | No | No | 7 | 7 | 1 | 2 | | R:R:V86 | R:R:Y316 | 5.05 | 1 | No | No | 7 | 6 | 2 | 2 | | R:R:D113 | R:R:Y316 | 11.49 | 1 | No | No | 7 | 6 | 1 | 2 | | R:R:S165 | R:R:V114 | 6.46 | 0 | No | No | 7 | 5 | 2 | 1 | | R:R:V117 | R:R:W286 | 3.68 | 0 | No | Yes | 6 | 8 | 1 | 2 | | R:R:F290 | R:R:S204 | 5.28 | 1 | Yes | No | 7 | 5 | 1 | 2 | | R:R:F208 | R:R:W286 | 3.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:F208 | R:R:F290 | 17.15 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:F289 | R:R:W286 | 5.01 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:F290 | R:R:W286 | 3.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | | R:R:F289 | R:R:F290 | 5.36 | 1 | Yes | Yes | 6 | 7 | 1 | 1 | | R:R:F289 | R:R:Y308 | 15.47 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | R:R:F289 | R:R:N312 | 16.92 | 1 | Yes | No | 6 | 5 | 1 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 9.76 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 19.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
