psnGPCR

Code	E5E
Name	Noradrenaline
Synonyms
Identifier	[(2~{R})-2-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-ethyl]azanium
Formula	C8 H12 N O3
Molecular Weight	170.186
SMILES	c1cc(c(cc1[C@H](C[NH3+])O)O)O
PubChem	6921840
Formal Charge	1
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6
Networks	3

This ligand is also present in the following 3 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7BU6

Amine

Adrenergic

Beta1

Homo sapiens

L-Norepinephrine

2.7

2020-12-02

10.1038/s41422-020-00424-2

A 2D representation of the interactions of E5E in 7BU6
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M107	R:R:V111	7.61	1	Yes	Yes	7	7	2	2
R:R:M107	R:R:Y367	3.59	1	Yes	Yes	7	8	2	1
R:R:D138	R:R:V111	7.3	1	No	Yes	7	7	1	2
R:R:V111	R:R:Y367	3.79	1	Yes	Yes	7	8	2	1
R:R:V112	R:R:Y367	5.05	0	No	Yes	7	8	2	1
R:R:D138	R:R:Y367	10.34	1	No	Yes	7	8	1	1
L:L:?1	R:R:D138	17	1	Yes	No	0	7	0	1
R:R:S190	R:R:V139	3.23	5	No	No	7	7	2	1
R:R:V139	R:R:Y224	3.79	0	No	Yes	7	7	1	2
L:L:?1	R:R:V139	17.33	1	Yes	No	0	7	0	1
R:R:V142	R:R:W337	9.81	0	No	Yes	6	8	1	2
L:L:?1	R:R:V142	8	1	Yes	No	0	6	0	1
R:R:S232	R:R:T143	9.59	0	No	Yes	7	7	1	2
R:R:F218	R:R:N344	4.83	1	No	Yes	6	6	1	1
R:R:F218	R:R:F359	3.22	1	No	Yes	6	5	1	2
L:L:?1	R:R:F218	16.35	1	Yes	No	0	6	0	1
R:R:S228	R:R:Y224	11.45	0	No	Yes	6	7	1	2
L:L:?1	R:R:S228	9.4	1	Yes	No	0	6	0	1
R:R:S229	R:R:Y234	3.82	1	Yes	Yes	7	5	2	2
R:R:F341	R:R:S229	5.28	1	Yes	Yes	7	7	1	2
R:R:N344	R:R:S229	4.47	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:S232	8.06	1	Yes	No	0	7	0	1
R:R:F233	R:R:Y234	9.28	1	Yes	Yes	8	5	2	2
R:R:F233	R:R:F341	21.43	1	Yes	Yes	8	7	2	1
R:R:F341	R:R:Y234	3.09	1	Yes	Yes	7	5	1	2
R:R:F340	R:R:W337	5.01	1	Yes	Yes	7	8	1	2
R:R:F341	R:R:W337	10.02	1	Yes	Yes	7	8	1	2
R:R:F340	R:R:F341	11.79	1	Yes	Yes	7	7	1	1
R:R:F340	R:R:N344	8.46	1	Yes	Yes	7	6	1	1
R:R:F340	R:R:F359	7.5	1	Yes	Yes	7	5	1	2
R:R:F340	R:R:N363	15.71	1	Yes	No	7	6	1	1
L:L:?1	R:R:F340	9.81	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F341	7.63	1	Yes	Yes	0	7	0	1
R:R:F359	R:R:N344	3.62	1	Yes	Yes	5	6	2	1
L:L:?1	R:R:N344	4.91	1	Yes	Yes	0	6	0	1
R:R:N363	R:R:Y367	11.63	1	No	Yes	6	8	1	1
L:L:?1	R:R:N363	14.74	1	Yes	No	0	6	0	1
R:R:W364	R:R:Y367	15.43	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y367	3.15	1	Yes	Yes	0	8	0	1

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	10.58
Average Nodes In Shell	24.00
Average Hubs In Shell	15.00
Average Links In Shell	39.00
Average Links Mediated by Hubs In Shell	38.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7EJ0

Amine

Adrenergic

Alpha2A

Homo sapiens

L-Norepinephrine

Go/Beta1/Gamma2

3.2

2022-04-13

10.1126/sciadv.abj5347

A 2D representation of the interactions of E5E in 7EJ0
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D128	R:R:V101	8.76	2	No	Yes	8	8	1	2
R:R:V101	R:R:Y431	6.31	2	Yes	Yes	8	8	2	1
R:R:D128	R:R:Y431	5.75	2	No	Yes	8	8	1	1
L:L:?1	R:R:D128	9.71	2	Yes	No	0	8	0	1
R:R:S180	R:R:V129	8.08	0	No	No	8	8	2	1
L:L:?1	R:R:V129	12	2	Yes	No	0	8	0	1
R:R:C132	R:R:W402	3.92	0	No	Yes	7	9	1	2
L:L:?1	R:R:C132	11.36	2	Yes	No	0	7	0	1
R:R:S219	R:R:T133	4.8	0	No	No	8	8	1	2
R:R:I205	R:R:Y409	2.42	0	No	Yes	7	8	2	1
R:R:V212	R:R:Y409	10.09	0	No	Yes	7	8	2	1
L:L:?1	R:R:S215	4.03	2	Yes	No	0	9	0	1
R:R:C216	R:R:F406	8.38	0	Yes	Yes	7	8	2	2
R:R:C216	R:R:Y409	2.69	0	Yes	Yes	7	8	2	1
R:R:F406	R:R:S219	5.28	2	Yes	No	8	8	2	1
L:L:?1	R:R:S219	5.37	2	Yes	No	0	8	0	1
R:R:F406	R:R:W402	8.02	2	Yes	Yes	8	9	2	2
R:R:F405	R:R:F406	2.14	2	Yes	Yes	8	8	1	2
R:R:F405	R:R:Y409	6.19	2	Yes	Yes	8	8	1	1
R:R:F405	R:R:F426	3.22	2	Yes	Yes	8	7	1	2
R:R:F405	R:R:F427	7.5	2	Yes	No	8	7	1	1
L:L:?1	R:R:F405	3.27	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y409	4.2	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:F427	3.27	2	Yes	No	0	7	0	1
L:L:?1	R:R:Y431	4.2	2	Yes	Yes	0	8	0	1
R:R:W428	R:R:Y431	1.93	2	Yes	Yes	7	8	2	1
R:R:A126	R:R:V129	1.7	0	No	No	8	8	2	1
R:R:I179	R:R:S215	1.55	0	No	No	8	9	2	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	6.38
Average Nodes In Shell	22.00
Average Hubs In Shell	10.00
Average Links In Shell	28.00
Average Links Mediated by Hubs In Shell	24.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7YMH

Amine

Adrenergic

Alpha1A

Homo sapiens

Norepinephrine

chim(Gs-CtGq)/Beta1/Gamma2

3.52

2023-07-05

10.1038/s41467-023-39310-x

A 2D representation of the interactions of E5E in 7YMH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L75	R:R:V79	4.47	1	Yes	Yes	8	8	2	2
R:R:C110	R:R:L75	3.17	0	No	Yes	6	8	1	2
R:R:L75	R:R:Y316	7.03	1	Yes	Yes	8	7	2	1
R:R:D106	R:R:V79	7.3	1	No	Yes	7	8	1	2
R:R:V79	R:R:Y316	3.79	1	Yes	Yes	8	7	2	1
R:R:L80	R:R:W313	3.42	1	Yes	Yes	8	6	2	2
R:R:L80	R:R:Y316	11.72	1	Yes	Yes	8	7	2	1
R:R:S83	R:R:W313	4.94	1	No	Yes	7	6	2	2
R:R:S83	R:R:Y316	5.09	1	No	Yes	7	7	2	1
R:R:D106	R:R:Y316	11.49	1	No	Yes	7	7	1	1
L:L:?1	R:R:D106	12.14	1	Yes	No	0	7	0	1
R:R:S158	R:R:V107	3.23	6	Yes	No	8	6	2	1
L:L:?1	R:R:V107	12	1	Yes	No	0	6	0	1
R:R:C110	R:R:W285	7.84	0	No	Yes	6	8	1	2
L:L:?1	R:R:C110	5.68	1	Yes	No	0	6	0	1
R:R:E180	R:R:I178	4.1	0	No	No	5	6	2	1
R:R:F312	R:R:I178	3.77	1	No	No	6	6	1	1
L:L:?1	R:R:I178	5.11	1	Yes	No	0	6	0	1
R:R:E180	R:R:M292	5.41	0	No	Yes	5	7	2	2
R:R:S188	R:R:Y184	2.54	0	No	Yes	7	8	1	2
L:L:?1	R:R:S188	2.69	1	Yes	No	0	7	0	1
R:R:A189	R:R:F289	2.77	0	No	Yes	7	7	2	1
R:R:F193	R:R:W285	3.01	1	Yes	Yes	8	8	2	2
R:R:F193	R:R:F289	18.22	1	Yes	Yes	8	7	2	1
R:R:F289	R:R:W285	4.01	1	Yes	Yes	7	8	1	2
R:R:F288	R:R:F289	7.5	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:M292	7.46	1	Yes	Yes	7	7	1	2
R:R:F288	R:R:V311	2.62	1	Yes	No	7	5	1	2
L:L:?1	R:R:F288	20.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F289	5.45	1	Yes	Yes	0	7	0	1
R:R:F312	R:R:Y316	8.25	1	No	Yes	6	7	1	1
L:L:?1	R:R:F312	10.9	1	Yes	No	0	6	0	1
R:R:W313	R:R:Y316	5.79	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y316	4.2	1	Yes	Yes	0	7	0	1

Statistics	Value
Average Number Of Links	9.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	8.76
Average Nodes In Shell	23.00
Average Hubs In Shell	13.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	32.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	9.67
Average Number Of Links With An Hub	3.33
Average Interaction Strength	8.57
Average Nodes In Shell	23.00
Average Hubs In Shell	12.67
Average Links In Shell	33.67
Average Links Mediated by Hubs In Shell	31.33

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)