CodeEIC
NameLinoleic acid
SynonymsPotassium linolate
Identifier(9Z,12Z)-octadeca-9,12-dienoic acid
FormulaC18 H32 O2
Molecular Weight280.445
SMILESCCCCC\C=C/C\C=C/CCCCCCCC(=O)O
PubChem5280450
Formal Charge0
Total Atoms52
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds0
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ID4 A Lipid Free fatty acid FFA4 (GPR120) Homo sapiens Linoleic acid - Gi1/Beta1/Gamma2 3.1 2023-03-15  10.1126/science.add6220

A 2D representation of the interactions of EIC in 8ID4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F25 R:R:F27 7.5 4 Yes Yes 5 5 2 1
R:R:F25 R:R:I287 5.02 4 Yes No 5 5 2 1
R:R:F25 R:R:F303 5.36 4 Yes Yes 5 4 2 2
R:R:F115 R:R:F27 8.57 4 Yes Yes 5 5 1 1
R:R:F177 R:R:F27 7.5 4 Yes Yes 5 5 2 1
R:R:F27 R:R:L196 4.87 4 Yes No 5 5 1 2
R:R:F27 R:R:F303 3.22 4 Yes Yes 5 4 1 2
L:L:?1 R:R:F27 4.89 4 Yes Yes 0 5 0 1
R:R:F115 R:R:F28 5.36 4 Yes Yes 5 8 1 2
R:R:F28 R:R:F303 6.43 4 Yes Yes 8 4 2 2
R:R:F88 R:R:S121 6.61 0 Yes No 7 8 1 2
R:R:F88 R:R:G122 3.01 0 Yes No 7 7 1 2
R:R:F311 R:R:F88 9.65 0 Yes Yes 7 7 2 1
L:L:?1 R:R:F88 4.89 4 Yes Yes 0 7 0 1
R:R:A91 R:R:M118 3.22 0 No Yes 6 7 2 1
R:R:F115 R:R:L114 3.65 4 Yes Yes 5 6 1 2
R:R:L114 R:R:M118 4.24 0 Yes Yes 6 7 2 1
R:R:F115 R:R:F177 7.5 4 Yes Yes 5 5 1 2
R:R:C194 R:R:F115 4.19 4 No Yes 9 5 2 1
L:L:?1 R:R:F115 2.94 4 Yes Yes 0 5 0 1
R:R:F311 R:R:M118 3.73 0 Yes Yes 7 7 2 1
L:L:?1 R:R:M118 6.82 4 Yes Yes 0 7 0 1
R:R:A170 R:R:T119 3.36 0 No Yes 7 5 2 1
R:R:L173 R:R:T119 4.42 0 No Yes 5 5 2 1
R:R:F211 R:R:T119 3.89 4 Yes Yes 5 5 1 1
L:L:?1 R:R:T119 4.74 4 Yes Yes 0 5 0 1
R:R:F177 R:R:L173 3.65 4 Yes No 5 5 2 2
R:R:L173 R:R:W207 7.97 0 No Yes 5 6 2 2
R:R:F177 R:R:L196 10.96 4 Yes No 5 5 2 2
R:R:L196 R:R:W198 7.97 4 No Yes 5 7 2 2
R:R:E204 R:R:W198 31.62 0 No Yes 5 7 1 2
R:R:W198 R:R:W207 11.25 0 Yes Yes 7 6 2 2
R:R:E204 R:R:N291 9.2 0 No No 5 2 1 2
L:L:?1 R:R:E204 4.26 4 Yes No 0 5 0 1
R:R:D208 R:R:W207 7.82 4 Yes Yes 5 6 1 2
R:R:F211 R:R:W207 7.02 4 Yes Yes 5 6 1 2
R:R:D208 R:R:I284 4.2 4 Yes No 5 5 1 1
R:R:D208 R:R:L288 6.79 4 Yes No 5 4 1 2
L:L:?1 R:R:D208 10.9 4 Yes Yes 0 5 0 1
R:R:F211 R:R:N215 9.67 4 Yes Yes 5 6 1 2
L:L:?1 R:R:F211 4.89 4 Yes Yes 0 5 0 1
R:R:I280 R:R:I284 4.42 4 No No 6 5 1 1
R:R:I280 R:R:T310 4.56 4 No No 6 8 1 2
L:L:?1 R:R:I280 8.03 4 Yes No 0 6 0 1
L:L:?1 R:R:I284 4.59 4 Yes No 0 5 0 1
L:L:?1 R:R:I287 4.59 4 Yes No 0 5 0 1
R:R:A169 R:R:F211 2.77 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength5.59
Average Nodes In Shell32.00
Average Hubs In Shell17.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength5.59
Average Nodes In Shell32.00
Average Hubs In Shell17.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell44.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)