CodeEIC
NameLinoleic acid
Synonyms9Z,12Z-octadecadienoic acid
Identifier
FormulaC18 H32 O2
Molecular Weight280.445
SMILES
PubChem5280450
Formal Charge0
Total Atoms52
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ID4 A Lipid Free Fatty Acid FFA4 Homo Sapiens Linoleic acid - Gi1/Beta1/Gamma2 3.1 2023-03-15  10.1126/science.add6220

A 2D representation of the interactions of EIC in 8ID4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F27 4.89 4 Yes Yes 0 5 0 1
L:L:?1 R:R:F88 4.89 4 Yes Yes 0 7 0 1
L:L:?1 R:R:F115 2.94 4 Yes Yes 0 5 0 1
L:L:?1 R:R:M118 6.82 4 Yes Yes 0 7 0 1
L:L:?1 R:R:T119 4.74 4 Yes Yes 0 5 0 1
L:L:?1 R:R:L196 3.34 4 Yes No 0 5 0 1
L:L:?1 R:R:E204 4.26 4 Yes No 0 5 0 1
L:L:?1 R:R:D208 10.9 4 Yes Yes 0 5 0 1
L:L:?1 R:R:F211 4.89 4 Yes Yes 0 5 0 1
L:L:?1 R:R:I280 8.03 4 Yes No 0 6 0 1
L:L:?1 R:R:I284 4.59 4 Yes No 0 5 0 1
L:L:?1 R:R:I287 4.59 4 Yes No 0 5 0 1
R:R:F25 R:R:F27 7.5 4 Yes Yes 5 5 2 1
R:R:F25 R:R:I287 5.02 4 Yes No 5 5 2 1
R:R:F25 R:R:F303 5.36 4 Yes Yes 5 4 2 2
R:R:F115 R:R:F27 8.57 4 Yes Yes 5 5 1 1
R:R:F177 R:R:F27 7.5 4 Yes Yes 5 5 2 1
R:R:F27 R:R:F303 3.22 4 Yes Yes 5 4 1 2
R:R:F115 R:R:F28 5.36 4 Yes Yes 5 8 1 2
R:R:F28 R:R:F303 6.43 4 Yes Yes 8 4 2 2
R:R:F88 R:R:S121 6.61 0 Yes No 7 8 1 2
R:R:F88 R:R:G122 3.01 0 Yes No 7 7 1 2
R:R:F311 R:R:F88 9.65 0 Yes Yes 7 7 2 1
R:R:A91 R:R:M118 3.22 0 No Yes 6 7 2 1
R:R:F115 R:R:L114 3.65 4 Yes No 5 6 1 2
R:R:L114 R:R:M118 4.24 0 No Yes 6 7 2 1
R:R:F115 R:R:F177 7.5 4 Yes Yes 5 5 1 2
R:R:F311 R:R:M118 3.73 0 Yes Yes 7 7 2 1
R:R:A170 R:R:T119 3.36 0 No Yes 7 5 2 1
R:R:L173 R:R:T119 4.42 0 No Yes 5 5 2 1
R:R:F211 R:R:T119 3.89 4 Yes Yes 5 5 1 1
R:R:F177 R:R:L173 3.65 4 Yes No 5 5 2 2
R:R:L173 R:R:W207 7.97 0 No Yes 5 6 2 2
R:R:F177 R:R:L196 12.18 4 Yes No 5 5 2 1
R:R:L196 R:R:W198 17.08 0 No Yes 5 7 1 2
R:R:E204 R:R:W198 31.62 0 No Yes 5 7 1 2
R:R:W198 R:R:W207 11.25 0 Yes Yes 7 6 2 2
R:R:E204 R:R:N291 9.2 0 No No 5 2 1 2
R:R:D208 R:R:W207 7.82 4 Yes Yes 5 6 1 2
R:R:F211 R:R:W207 7.02 4 Yes Yes 5 6 1 2
R:R:D208 R:R:I284 4.2 4 Yes No 5 5 1 1
R:R:D208 R:R:L288 6.79 4 Yes No 5 4 1 2
R:R:F211 R:R:N215 9.67 4 Yes Yes 5 6 1 2
R:R:I280 R:R:I284 4.42 4 No No 6 5 1 1
R:R:I280 R:R:T310 4.56 4 No No 6 8 1 2
R:R:A169 R:R:F211 2.77 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength5.41
Average Nodes In Shell31.00
Average Hubs In Shell16.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell43.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.50
Average Interaction Strength5.63
Average Nodes In Shell29.50
Average Hubs In Shell15.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell39.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)