psnGPCR

Code	EIG
Name	Mitragynine pseudoindoxyl
Synonyms	methyl (2E)-4-[(2S,2'S)-1'-butyl-4-methoxy-3-oxo-1,3-dihydrospiro[indole-2,3'-pyrrolidin]-2'-yl]-2-(methoxymethylidene)butanoate
Identifier
Formula	C23 H30 N2 O5
Molecular Weight	414.495
SMILES
PubChem	44301701
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	4
Total Bonds	63
Total Aromatic Bonds	6
Networks	6

This ligand is also present in the following 6 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7T2G

Peptide

Opioid

MOP

Mus Musculus

Mitragynine Pseudoindoxyl

Gi1/Beta1/Gamma2

2.5

2022-12-07

doi.org/10.1038/s41589-022-01208-y

A 2D representation of the interactions of EIG in 7T2G
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I71	R:R:Y128	20.55	2	No	No	4	5	2	2
R:R:H319	R:R:I71	15.91	2	Yes	No	4	4	1	2
R:R:L121	R:R:Y75	3.52	2	Yes	Yes	7	7	2	1
R:R:H319	R:R:Y75	10.89	2	Yes	Yes	4	7	1	1
R:R:I322	R:R:Y75	9.67	2	Yes	Yes	5	7	1	1
L:L:?1	R:R:Y75	12.45	2	Yes	Yes	0	7	0	1
R:R:D147	R:R:T120	7.23	2	No	No	6	6	1	2
R:R:L121	R:R:Y326	17.58	2	Yes	No	7	7	2	1
R:R:N127	R:R:Q124	3.96	0	No	No	6	6	2	1
L:L:?1	R:R:Q124	24.95	2	Yes	No	0	6	0	1
R:R:H319	R:R:Y128	14.16	2	Yes	No	4	5	1	2
R:R:D147	R:R:Y326	11.49	2	No	No	6	7	1	1
L:L:?1	R:R:D147	24.59	2	Yes	No	0	6	0	1
R:R:I198	R:R:Y148	3.63	0	No	Yes	4	4	2	1
R:R:V202	R:R:Y148	15.14	2	No	Yes	5	4	2	1
R:R:L219	R:R:Y148	3.52	2	No	Yes	5	4	2	1
R:R:L232	R:R:Y148	7.03	0	No	Yes	5	4	2	1
L:L:?1	R:R:Y148	12.45	2	Yes	Yes	0	4	0	1
R:R:F152	R:R:M151	4.98	2	Yes	Yes	7	7	2	1
R:R:M151	R:R:V236	6.09	2	Yes	No	7	5	1	2
R:R:M151	R:R:W293	6.98	2	Yes	Yes	7	8	1	2
L:L:?1	R:R:M151	3.53	2	Yes	Yes	0	7	0	1
R:R:F152	R:R:I198	12.56	2	Yes	No	7	4	2	2
R:R:F152	R:R:V236	3.93	2	Yes	No	7	5	2	2
R:R:L219	R:R:V202	5.96	2	No	No	5	5	2	2
R:R:K233	R:R:V300	4.55	0	Yes	No	4	5	2	1
R:R:F237	R:R:H297	4.53	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	18.1	0	Yes	Yes	8	8	2	1
R:R:H297	R:R:W293	9.52	0	Yes	Yes	8	8	1	2
R:R:I296	R:R:W318	4.7	2	Yes	Yes	6	5	1	2
R:R:C321	R:R:I296	3.27	0	No	Yes	6	6	2	1
R:R:I296	R:R:I322	5.89	2	Yes	Yes	6	5	1	1
L:L:?1	R:R:I296	8.92	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:H297	4.82	2	Yes	Yes	0	8	0	1
R:R:V300	R:R:W318	4.9	0	No	Yes	5	5	1	2
L:L:?1	R:R:V300	3.72	2	Yes	No	0	5	0	1
R:R:H319	R:R:W318	5.29	2	Yes	Yes	4	5	1	2
R:R:I322	R:R:W318	10.57	2	Yes	Yes	5	5	1	2
L:L:?1	R:R:H319	5.62	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:I322	11.6	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y326	16.85	2	Yes	No	0	7	0	1
R:R:H319	R:R:T315	2.74	2	Yes	No	4	4	1	2
R:R:A323	R:R:Y75	2.67	0	No	Yes	4	7	2	1
R:R:S125	R:R:Y75	2.54	0	No	Yes	6	7	2	1

Statistics	Value
Average Number Of Links	11.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	11.77
Average Nodes In Shell	32.00
Average Hubs In Shell	14.00
Average Links In Shell	44.00
Average Links Mediated by Hubs In Shell	39.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9ODJ

Peptide

Opioid

MOP

Mus Musculus

Mitragynine Pseudoindoxyl

GTP; Mg

Gi1/Beta1/Gamma2

2026-01-07

10.1038/s41586-025-10056-4

A 2D representation of the interactions of EIG in 9ODJ
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y75	8.06	21	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q124	8.32	21	Yes	No	0	6	0	1
L:L:?1	R:R:D147	16.96	21	Yes	No	0	6	0	1
L:L:?1	R:R:Y148	12.45	21	Yes	No	0	4	0	1
L:L:?1	R:R:M151	3.53	21	Yes	Yes	0	7	0	1
L:L:?1	R:R:I296	6.24	21	Yes	No	0	6	0	1
L:L:?1	R:R:H297	4.02	21	Yes	Yes	0	8	0	1
L:L:?1	R:R:I322	7.14	21	Yes	No	0	5	0	1
L:L:?1	R:R:Y326	12.45	21	Yes	No	0	7	0	1
R:R:S125	R:R:Y75	5.09	0	No	Yes	6	7	2	1
R:R:H319	R:R:Y75	15.24	34	Yes	Yes	4	7	2	1
R:R:L121	R:R:Y326	8.21	0	Yes	No	7	7	2	1
R:R:N127	R:R:Q124	6.6	0	No	No	6	6	2	1
R:R:D147	R:R:Y326	5.75	21	No	No	6	7	1	1
R:R:V202	R:R:Y148	2.52	0	No	No	5	4	2	1
R:R:F152	R:R:M151	3.73	0	No	Yes	7	7	2	1
R:R:M151	R:R:W293	3.49	0	Yes	Yes	7	8	1	2
R:R:K233	R:R:V300	4.55	0	No	No	4	5	2	1
R:R:F237	R:R:H297	3.39	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	5.66	0	No	Yes	8	8	2	1
R:R:H297	R:R:W293	4.23	21	Yes	Yes	8	8	1	2
R:R:H297	R:R:I296	2.65	21	Yes	No	8	6	1	1
R:R:I322	R:R:W318	9.4	0	No	No	5	5	1	2
R:R:L232	R:R:Y148	2.34	0	No	No	5	4	2	1
L:L:?1	R:R:V300	1.86	21	Yes	No	0	5	0	1
R:R:M151	R:R:V236	1.52	0	Yes	No	7	5	1	2
R:R:L74	R:R:Y75	1.17	0	No	Yes	5	7	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	8.10
Average Nodes In Shell	25.00
Average Hubs In Shell	7.00
Average Links In Shell	27.00
Average Links Mediated by Hubs In Shell	21.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

9ODL

Peptide

Opioid

MOP

Mus Musculus

Mitragynine Pseudoindoxyl

GTP; Mg

Gi1/Beta1/Gamma2

3.6

2026-01-07

10.1038/s41586-025-10056-4

A 2D representation of the interactions of EIG in 9ODL
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y75	3.66	7	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q124	14.97	7	Yes	No	0	6	0	1
L:L:?1	R:R:D147	7.63	7	Yes	No	0	6	0	1
L:L:?1	R:R:Y148	6.59	7	Yes	Yes	0	4	0	1
L:L:?1	R:R:M151	10.6	7	Yes	No	0	7	0	1
L:L:?1	R:R:I296	11.6	7	Yes	Yes	0	6	0	1
L:L:?1	R:R:H297	4.02	7	Yes	Yes	0	8	0	1
L:L:?1	R:R:V300	5.59	7	Yes	No	0	5	0	1
L:L:?1	R:R:H319	4.82	7	Yes	No	0	4	0	1
L:L:?1	R:R:I322	18.73	7	Yes	No	0	5	0	1
R:R:I71	R:R:Y75	4.84	0	No	Yes	4	7	2	1
R:R:L121	R:R:Y75	5.86	0	No	Yes	7	7	2	1
R:R:S125	R:R:Y75	7.63	0	No	Yes	6	7	2	1
R:R:L121	R:R:Y326	8.21	0	No	Yes	7	7	2	2
R:R:Q124	R:R:Y326	3.38	0	No	Yes	6	7	1	2
R:R:H319	R:R:Y128	3.27	0	No	No	4	5	1	2
R:R:D147	R:R:Y326	9.2	0	No	Yes	6	7	1	2
R:R:V202	R:R:Y148	11.36	7	No	Yes	5	4	2	1
R:R:L219	R:R:Y148	3.52	7	Yes	Yes	5	4	2	1
R:R:L232	R:R:Y148	4.69	0	No	Yes	5	4	2	1
R:R:M151	R:R:W293	5.82	0	No	Yes	7	8	1	2
R:R:L219	R:R:V202	4.47	7	Yes	No	5	5	2	2
R:R:F237	R:R:H297	6.79	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	21.5	0	No	Yes	8	8	2	1
R:R:H297	R:R:I296	3.98	7	Yes	Yes	8	6	1	1
R:R:C321	R:R:I296	6.55	0	No	Yes	6	6	2	1
R:R:I296	R:R:I322	5.89	7	Yes	No	6	5	1	1
R:R:V300	R:R:Y299	7.57	7	No	No	5	4	1	2
R:R:W318	R:R:Y299	25.08	7	No	No	5	4	2	2
R:R:V300	R:R:W318	2.45	7	No	No	5	5	1	2
R:R:H319	R:R:T315	2.74	0	No	No	4	4	1	2
R:R:L74	R:R:Y75	2.34	0	No	Yes	5	7	2	1
R:R:M151	R:R:V236	1.52	0	No	No	7	5	1	2
R:R:A240	R:R:H297	1.46	0	No	Yes	6	8	2	1

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	8.82
Average Nodes In Shell	29.00
Average Hubs In Shell	8.00
Average Links In Shell	34.00
Average Links Mediated by Hubs In Shell	28.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	10.00
Average Number Of Links With An Hub	4.17
Average Interaction Strength	9.87
Average Nodes In Shell	27.50
Average Hubs In Shell	8.50
Average Links In Shell	32.83
Average Links Mediated by Hubs In Shell	26.83

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)