CodeEPA
NameIcosapent
SynonymsTimnodonic acid
Identifier(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
FormulaC20 H30 O2
Molecular Weight302.451
SMILESCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
PubChem446284
Formal Charge0
Total Atoms52
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds0
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ID9 A Lipid Free fatty acid FFA4 (GPR120) Homo sapiens Eicosapentaenoic acid - Gi1/Beta1/Gamma2 3 2023-03-15  10.1126/science.add6220

A 2D representation of the interactions of EPA in 8ID9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F25 R:R:F27 12.86 3 Yes Yes 5 5 2 2
R:R:F25 R:R:I287 6.28 3 Yes Yes 5 5 2 1
R:R:F25 R:R:Q290 3.51 3 Yes No 5 4 2 2
R:R:F25 R:R:F303 5.36 3 Yes Yes 5 4 2 1
R:R:F115 R:R:F27 7.5 0 Yes Yes 5 5 1 2
R:R:F27 R:R:L196 6.09 3 Yes No 5 5 2 1
R:R:F27 R:R:F303 8.57 3 Yes Yes 5 4 2 1
R:R:F28 R:R:F303 4.29 3 No Yes 8 4 2 1
R:R:F28 R:R:V307 9.18 3 No No 8 5 2 2
R:R:F88 R:R:S121 10.57 0 Yes No 7 8 1 2
R:R:F88 R:R:G122 3.01 0 Yes No 7 7 1 2
R:R:F311 R:R:F88 10.72 0 Yes Yes 7 7 2 1
R:R:F88 R:R:S314 5.28 0 Yes Yes 7 9 1 2
L:L:?1 R:R:F88 5.15 3 Yes Yes 0 7 0 1
R:R:A91 R:R:M118 3.22 0 No No 6 7 2 1
R:R:F115 R:R:L114 4.87 0 Yes No 5 6 1 2
R:R:F115 R:R:F177 15 0 Yes No 5 5 1 2
L:L:?1 R:R:F115 3.43 3 Yes Yes 0 5 0 1
R:R:F311 R:R:M118 3.73 0 Yes No 7 7 2 1
L:L:?1 R:R:M118 4.98 3 Yes No 0 7 0 1
R:R:F211 R:R:T119 3.89 0 Yes No 5 5 1 2
R:R:P172 R:R:W198 2.7 3 No Yes 8 7 2 1
R:R:P172 R:R:W207 16.21 3 No Yes 8 6 2 2
R:R:L196 R:R:W198 15.94 3 No Yes 5 7 1 1
L:L:?1 R:R:L196 3.9 3 Yes No 0 5 0 1
R:R:E204 R:R:W198 8.72 0 No Yes 5 7 2 1
R:R:W198 R:R:W207 10.31 3 Yes Yes 7 6 1 2
L:L:?1 R:R:W198 3.21 3 Yes Yes 0 7 0 1
R:R:E204 R:R:L288 3.98 0 No Yes 5 4 2 1
R:R:I205 R:R:L288 4.28 0 No Yes 4 4 2 1
R:R:D208 R:R:W207 4.47 3 Yes Yes 5 6 1 2
R:R:F211 R:R:W207 22.05 0 Yes Yes 5 6 1 2
R:R:D208 R:R:I284 2.8 3 Yes No 5 5 1 1
R:R:D208 R:R:L288 12.21 3 Yes Yes 5 4 1 1
L:L:?1 R:R:D208 9.56 3 Yes Yes 0 5 0 1
R:R:F211 R:R:N215 7.25 0 Yes Yes 5 6 1 2
L:L:?1 R:R:F211 6.87 3 Yes Yes 0 5 0 1
R:R:I280 R:R:I281 2.94 0 Yes No 6 7 1 2
R:R:I280 R:R:T283 4.56 0 Yes No 6 5 1 2
R:R:I280 R:R:T310 6.08 0 Yes No 6 8 1 2
L:L:?1 R:R:I280 9.05 3 Yes Yes 0 6 0 1
L:L:?1 R:R:I284 8.05 3 Yes No 0 5 0 1
R:R:I287 R:R:Q290 2.74 3 Yes No 5 4 1 2
R:R:F303 R:R:I287 3.77 3 Yes Yes 4 5 1 1
L:L:?1 R:R:I287 4.02 3 Yes Yes 0 5 0 1
L:L:?1 R:R:L288 2.93 3 Yes Yes 0 4 0 1
R:R:F303 R:R:V307 5.24 3 Yes No 4 5 1 2
L:L:?1 R:R:F303 3.43 3 Yes Yes 0 4 0 1
R:R:F311 R:R:V307 5.24 0 Yes No 7 5 2 2
R:R:L285 R:R:L288 1.38 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub9.00
Average Interaction Strength5.38
Average Nodes In Shell35.00
Average Hubs In Shell16.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell48.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub9.00
Average Interaction Strength5.38
Average Nodes In Shell35.00
Average Hubs In Shell16.00
Average Links In Shell50.00
Average Links Mediated by Hubs In Shell48.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)