CodeEPA
NameIcosapent
Synonymscis-5,8,11,14,17-eicosapentaenoic acid
Identifier
FormulaC20 H30 O2
Molecular Weight302.451
SMILES
PubChem446284
Formal Charge0
Total Atoms52
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds0
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ID9 A Lipid Free Fatty Acid FFA4 Homo Sapiens Eicosapentaenoic acid - Gi1/Beta1/Gamma2 3 2023-03-15  10.1126/science.add6220

A 2D representation of the interactions of EPA in 8ID9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F88 5.15 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F115 3.43 2 Yes Yes 0 5 0 1
L:L:?1 R:R:M118 4.98 2 Yes No 0 7 0 1
L:L:?1 R:R:G122 2.41 2 Yes Yes 0 7 0 1
L:L:?1 R:R:L196 6.83 2 Yes No 0 5 0 1
L:L:?1 R:R:W198 3.21 2 Yes Yes 0 7 0 1
L:L:?1 R:R:D208 9.56 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F211 6.87 2 Yes Yes 0 5 0 1
L:L:?1 R:R:W277 2.41 2 Yes Yes 0 9 0 1
L:L:?1 R:R:I280 9.05 2 Yes Yes 0 6 0 1
L:L:?1 R:R:I284 8.05 2 Yes No 0 5 0 1
L:L:?1 R:R:I287 4.02 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L288 2.93 2 Yes Yes 0 4 0 1
L:L:?1 R:R:F303 3.43 2 Yes Yes 0 4 0 1
R:R:F25 R:R:F27 12.86 2 Yes Yes 5 5 2 2
R:R:F25 R:R:I287 6.28 2 Yes Yes 5 5 2 1
R:R:F25 R:R:Q290 3.51 2 Yes No 5 4 2 2
R:R:F25 R:R:F303 5.36 2 Yes Yes 5 4 2 1
R:R:F115 R:R:F27 7.5 0 Yes Yes 5 5 1 2
R:R:F27 R:R:L196 6.09 2 Yes No 5 5 2 1
R:R:F27 R:R:I287 2.51 2 Yes Yes 5 5 2 1
R:R:F27 R:R:F303 8.57 2 Yes Yes 5 4 2 1
R:R:F115 R:R:F28 2.14 0 Yes Yes 5 8 1 2
R:R:F28 R:R:F303 4.29 2 Yes Yes 8 4 2 1
R:R:F28 R:R:V307 9.18 2 Yes No 8 5 2 2
R:R:F88 R:R:S121 10.57 2 Yes No 7 8 1 2
R:R:F88 R:R:G122 3.01 2 Yes Yes 7 7 1 1
R:R:F311 R:R:F88 10.72 0 Yes Yes 7 7 2 1
R:R:F88 R:R:S314 5.28 2 Yes Yes 7 9 1 2
R:R:A91 R:R:M118 3.22 0 No No 6 7 2 1
R:R:F115 R:R:L114 4.87 0 Yes No 5 6 1 2
R:R:F115 R:R:F177 15 0 Yes No 5 5 1 2
R:R:F311 R:R:M118 3.73 0 Yes No 7 7 2 1
R:R:F211 R:R:T119 3.89 0 Yes No 5 5 1 2
R:R:G122 R:R:T125 3.64 2 Yes No 7 9 1 2
R:R:G122 R:R:W277 2.81 2 Yes Yes 7 9 1 1
R:R:T125 R:R:W277 2.43 2 No Yes 9 9 2 1
R:R:F273 R:R:I126 5.02 2 Yes No 9 8 2 2
R:R:I126 R:R:W277 14.09 2 No Yes 8 9 2 1
R:R:P172 R:R:W198 2.7 2 No Yes 8 7 2 1
R:R:P172 R:R:W207 16.21 2 No Yes 8 6 2 2
R:R:L196 R:R:W198 9.11 2 No Yes 5 7 1 1
R:R:E204 R:R:W198 11.99 0 No Yes 5 7 2 1
R:R:W198 R:R:W207 10.31 2 Yes Yes 7 6 1 2
R:R:I205 R:R:L288 4.28 0 No Yes 4 4 2 1
R:R:D208 R:R:W207 4.47 2 Yes Yes 5 6 1 2
R:R:F211 R:R:W207 22.05 0 Yes Yes 5 6 1 2
R:R:D208 R:R:I284 2.8 2 Yes No 5 5 1 1
R:R:D208 R:R:L288 12.21 2 Yes Yes 5 4 1 1
R:R:F211 R:R:N215 7.25 0 Yes Yes 5 6 1 2
R:R:F216 R:R:F273 4.29 2 Yes Yes 8 9 2 2
R:R:F216 R:R:W277 3.01 2 Yes Yes 8 9 2 1
R:R:F216 R:R:I281 12.56 2 Yes No 8 7 2 2
R:R:F273 R:R:W277 6.01 2 Yes Yes 9 9 2 1
R:R:T310 R:R:W277 3.64 0 No Yes 8 9 2 1
R:R:N313 R:R:W277 27.12 0 No Yes 9 9 2 1
R:R:I280 R:R:I281 2.94 0 Yes No 6 7 1 2
R:R:I280 R:R:T283 4.56 0 Yes No 6 5 1 2
R:R:I280 R:R:T310 6.08 0 Yes No 6 8 1 2
R:R:I287 R:R:Q290 2.74 2 Yes No 5 4 1 2
R:R:F303 R:R:I287 3.77 2 Yes Yes 4 5 1 1
R:R:F303 R:R:V307 5.24 2 Yes No 4 5 1 2
R:R:F311 R:R:V307 5.24 0 Yes No 7 5 2 2
R:R:L285 R:R:L288 1.38 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub11.00
Average Interaction Strength5.17
Average Nodes In Shell41.00
Average Hubs In Shell21.00
Average Links In Shell64.00
Average Links Mediated by Hubs In Shell63.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.50
Average Interaction Strength5.99
Average Nodes In Shell32.50
Average Hubs In Shell15.00
Average Links In Shell46.50
Average Links Mediated by Hubs In Shell43.50

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)