Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6DDE | A | Peptide | Opioid | MOP | Mus musculus | Damgo | - | Gi1/Beta1/Gamma2 | 3.5 | 2018-06-13 | 10.1038/s41586-018-0219-7 |
![](/psngpcr/ligands/ETA/ETA_6DDE_L_L_5.png)
A 2D representation of the interactions of ETA in 6DDE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?4 | R:R:Q124 | 9.1 | 0 | Yes | No | 0 | 6 | 1 | 2 | L:L:?4 | R:R:W133 | 3.89 | 0 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:?4 | R:R:I144 | 13.41 | 0 | Yes | Yes | 0 | 5 | 1 | 2 | R:R:W318 | R:R:Y299 | 12.54 | 2 | Yes | No | 5 | 4 | 1 | 2 | R:R:K303 | R:R:W318 | 3.48 | 2 | No | Yes | 4 | 5 | 1 | 1 | L:L:?5 | R:R:K303 | 5.76 | 2 | No | No | 0 | 4 | 0 | 1 | L:L:?2 | R:R:W318 | 9.27 | 2 | Yes | Yes | 0 | 5 | 2 | 1 | L:L:?5 | R:R:W318 | 6.21 | 2 | No | Yes | 0 | 5 | 0 | 1 | L:L:?2 | L:L:G3 | 6.96 | 2 | Yes | No | 0 | 0 | 2 | 2 | L:L:?4 | L:L:G3 | 8.77 | 0 | Yes | No | 0 | 0 | 1 | 2 | L:L:?4 | L:L:?5 | 20.94 | 0 | Yes | No | 0 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 3.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 10.97 | Average Nodes In Shell | 10.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 11.00 | Average Links Mediated by Hubs In Shell | 10.00 |
| ![](/psngpcr/ligands/ETA/ETA_6DDE_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ETA/ETA_6DDE_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6DDF | A | Peptide | Opioid | MOP | Mus musculus | Damgo | - | Gi1/Beta1/Gamma2 | 3.5 | 2018-06-13 | 10.1038/s41586-018-0219-7 |
![](/psngpcr/ligands/ETA/ETA_6DDF_L_L_5.png)
A 2D representation of the interactions of ETA in 6DDF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D147 | R:R:Q124 | 2.61 | 1 | Yes | Yes | 6 | 6 | 2 | 2 | L:L:?4 | R:R:Q124 | 6.82 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:V143 | R:R:W133 | 7.36 | 1 | No | Yes | 5 | 8 | 2 | 2 | R:R:C217 | R:R:W133 | 20.89 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | L:L:?4 | R:R:W133 | 4.86 | 1 | Yes | Yes | 0 | 8 | 1 | 2 | L:L:?4 | R:R:V143 | 3.82 | 1 | Yes | No | 0 | 5 | 1 | 2 | R:R:C217 | R:R:I144 | 3.27 | 1 | Yes | Yes | 9 | 5 | 2 | 2 | L:L:?4 | R:R:I144 | 10.97 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?4 | R:R:D147 | 3.48 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?4 | R:R:C217 | 4.07 | 1 | Yes | Yes | 0 | 9 | 1 | 2 | R:R:C321 | R:R:I296 | 4.91 | 0 | No | Yes | 6 | 6 | 2 | 2 | R:R:I296 | R:R:I322 | 2.94 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | L:L:Y1 | R:R:I296 | 3.63 | 1 | Yes | Yes | 0 | 6 | 2 | 2 | L:L:?2 | R:R:I296 | 2.9 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:K303 | R:R:Y299 | 11.94 | 1 | No | No | 4 | 4 | 1 | 2 | R:R:W318 | R:R:Y299 | 13.5 | 1 | Yes | No | 5 | 4 | 1 | 2 | R:R:K303 | R:R:W318 | 3.48 | 1 | No | Yes | 4 | 5 | 1 | 1 | L:L:?5 | R:R:K303 | 5.76 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:C321 | R:R:W318 | 2.61 | 0 | No | Yes | 6 | 5 | 2 | 1 | L:L:?2 | R:R:W318 | 10.43 | 1 | Yes | Yes | 0 | 5 | 1 | 1 | L:L:?5 | R:R:W318 | 7.76 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?2 | R:R:I322 | 5.81 | 1 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?2 | L:L:Y1 | 11.93 | 1 | Yes | Yes | 0 | 0 | 1 | 2 | L:L:?2 | L:L:G3 | 6.96 | 1 | Yes | No | 0 | 0 | 1 | 2 | L:L:?2 | L:L:?4 | 4.81 | 1 | Yes | Yes | 0 | 0 | 1 | 1 | L:L:?2 | L:L:?5 | 7.67 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | L:L:?4 | L:L:G3 | 5.84 | 1 | Yes | No | 0 | 0 | 1 | 2 | L:L:?4 | L:L:?5 | 20.94 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 4.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 10.53 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/ETA/ETA_6DDF_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ETA/ETA_6DDF_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8EFQ | A | Peptide | Opioid | MOP | Homo sapiens | Damgo | - | Gi1/Beta1/Gamma2 | 3.3 | 2022-11-09 | 10.1016/j.cell.2022.09.041 |
![](/psngpcr/ligands/ETA/ETA_8EFQ_L_L_5.png)
A 2D representation of the interactions of ETA in 8EFQ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | L:L:?2 | L:L:G3 | 6.96 | 2 | Yes | No | 0 | 0 | 2 | 2 | L:L:?2 | L:L:?4 | 2.41 | 2 | Yes | Yes | 0 | 0 | 2 | 1 | L:L:?4 | L:L:G3 | 10.23 | 2 | Yes | No | 0 | 0 | 1 | 2 | L:L:G3 | R:R:Q126 | 3.29 | 2 | No | Yes | 0 | 6 | 2 | 2 | L:L:?4 | R:R:Q126 | 9.1 | 2 | Yes | Yes | 0 | 6 | 1 | 2 | L:L:?4 | R:R:N129 | 3.52 | 2 | Yes | No | 0 | 4 | 1 | 2 | L:L:?4 | R:R:V145 | 3.82 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | L:L:?4 | L:L:?5 | 27.39 | 2 | Yes | No | 0 | 0 | 1 | 0 | R:R:K211 | R:R:T220 | 3 | 24 | No | No | 1 | 4 | 2 | 1 | L:L:?5 | R:R:T220 | 2.01 | 0 | No | No | 0 | 4 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 2.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 14.70 | Average Nodes In Shell | 9.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 10.00 | Average Links Mediated by Hubs In Shell | 8.00 |
| ![](/psngpcr/ligands/ETA/ETA_8EFQ_L_L_5_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/ETA/ETA_8EFQ_L_L_5_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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