psnGPCR

Code	FI7
Name	2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier
Formula	C19 H22 N4 O5
Molecular Weight	386.402
SMILES
PubChem	135416394
Formal Charge	0
Total Atoms	50
Total Chiral Atoms	0
Total Bonds	52
Total Aromatic Bonds	11
Networks	14

This ligand is also present in the following 14 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XK2

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

3.1

2023-02-22

10.1038/s41467-023-37177-6

A 2D representation of the interactions of FI7 in 7XK2
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	3.53	5	Yes	No	0	6	0	1
L:L:?1	R:R:L104	4.42	5	Yes	No	0	5	0	1
L:L:?1	R:R:L107	18.54	5	Yes	No	0	6	0	1
L:L:?1	R:R:A108	5.03	5	Yes	No	0	4	0	1
L:L:?1	R:R:R111	4.65	5	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q112	5.94	5	Yes	No	0	7	0	1
L:L:?1	R:R:L158	3.53	5	Yes	No	0	5	0	1
L:L:?1	R:R:L162	9.71	5	Yes	No	0	4	0	1
L:L:?1	R:R:S179	5.75	5	Yes	No	0	4	0	1
L:L:?1	R:R:F180	13.99	5	Yes	No	0	3	0	1
L:L:?1	R:R:H189	15.58	5	Yes	No	0	5	0	1
L:L:?1	R:R:M192	7.22	5	Yes	No	0	5	0	1
L:L:?1	R:R:F277	3.89	5	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	7.95	5	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	4.49	5	Yes	Yes	0	7	0	1
R:R:E37	R:R:Y284	8.98	0	Yes	Yes	7	7	2	1
R:R:L83	R:R:Y284	5.86	5	No	Yes	6	7	1	1
R:R:W91	R:R:Y87	16.4	5	Yes	Yes	4	6	2	2
R:R:F277	R:R:Y87	4.13	5	Yes	Yes	5	6	1	2
R:R:F277	R:R:W91	4.01	5	Yes	Yes	5	4	1	2
R:R:F193	R:R:R111	4.28	0	No	Yes	6	8	2	1
R:R:F244	R:R:R111	4.28	5	Yes	Yes	8	8	2	1
R:R:R111	R:R:T283	5.17	5	Yes	No	8	8	1	2
R:R:Q112	R:R:T155	4.25	0	No	No	7	7	1	2
R:R:E196	R:R:Q112	16.57	0	No	No	5	7	2	1
R:R:L158	R:R:M192	4.24	5	No	No	5	5	1	1
R:R:F180	R:R:R251	10.69	5	No	No	3	5	1	2
R:R:F180	R:R:F276	8.57	5	No	Yes	3	4	1	2
R:R:M192	R:R:W188	9.31	5	No	No	5	5	1	2
R:R:E190	R:R:H189	19.69	0	No	No	4	5	2	1
R:R:E196	R:R:F193	5.83	0	No	No	5	6	2	2
R:R:F244	R:R:T283	7.78	5	Yes	No	8	8	2	2
R:R:F276	R:R:R251	11.76	5	Yes	No	4	5	2	2
R:R:D273	R:R:F277	4.78	0	No	Yes	4	5	2	1
R:R:F276	R:R:L280	8.53	5	Yes	No	4	5	2	1
R:R:F277	R:R:L280	3.65	5	Yes	No	5	5	1	1
R:R:S281	R:R:Y284	3.82	0	No	Yes	6	7	2	1
R:R:T283	R:R:Y284	3.75	5	No	Yes	8	7	2	1

Statistics	Value
Average Number Of Links	15.00
Average Number Of Links With An Hub	3.00
Average Interaction Strength	7.61
Average Nodes In Shell	30.00
Average Hubs In Shell	9.00
Average Links In Shell	38.00
Average Links Mediated by Hubs In Shell	31.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IHF

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.97

2023-08-30

10.1038/s41467-023-41650-7

A 2D representation of the interactions of FI7 in 8IHF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	4.48	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W91	2.95	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L104	7.17	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L107	9.86	1	Yes	No	0	6	0	1
L:L:?1	R:R:A108	7.14	1	Yes	No	0	4	0	1
L:L:?1	R:R:R111	9.44	1	Yes	No	0	8	0	1
L:L:?1	R:R:Q112	8.62	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L158	3.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T159	5.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:H161	3.33	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L162	8.07	1	Yes	No	0	4	0	1
L:L:?1	R:R:S178	3.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:S179	9.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:F180	20.51	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	15.82	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	10.07	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E196	4.29	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F277	3.94	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	6.27	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	6.83	1	Yes	Yes	0	7	0	1
R:R:R22	R:R:W91	3	1	Yes	Yes	3	4	2	1
R:R:E37	R:R:L34	3.98	1	Yes	No	7	8	2	2
R:R:L34	R:R:Y284	5.86	1	No	Yes	8	7	2	1
R:R:E37	R:R:L80	2.65	1	Yes	No	7	8	2	2
R:R:E37	R:R:Y284	6.73	1	Yes	Yes	7	7	2	1
R:R:L80	R:R:Y284	4.69	1	No	Yes	8	7	2	1
R:R:L83	R:R:Y87	5.86	1	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	4.24	1	Yes	Yes	6	5	1	2
R:R:L107	R:R:L83	6.92	1	No	Yes	6	6	1	1
R:R:N86	R:R:W91	10.17	0	No	Yes	5	4	2	1
R:R:W91	R:R:Y87	8.68	1	Yes	Yes	4	6	1	2
R:R:S178	R:R:W91	6.18	1	No	Yes	4	4	1	1
R:R:F277	R:R:W91	10.02	1	Yes	Yes	5	4	1	1
R:R:L104	R:R:M103	2.83	1	Yes	Yes	5	5	1	2
R:R:L107	R:R:M103	2.83	1	No	Yes	6	5	1	2
R:R:L104	R:R:L162	2.77	1	Yes	No	5	4	1	1
R:R:C177	R:R:L104	4.76	1	No	Yes	9	5	2	1
R:R:F105	R:R:M109	8.71	1	No	Yes	6	5	2	2
R:R:F105	R:R:T159	6.49	1	No	Yes	6	7	2	1
R:R:A108	R:R:T159	3.36	1	No	Yes	4	7	1	1
R:R:M109	R:R:T159	3.01	1	Yes	Yes	5	7	2	1
R:R:E196	R:R:R111	3.49	1	Yes	No	5	8	1	1
R:R:R111	R:R:T283	6.47	1	No	No	8	8	1	2
R:R:Q112	R:R:T155	2.83	1	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	5.32	1	Yes	Yes	5	7	1	1
R:R:M192	R:R:Q112	2.72	1	Yes	Yes	5	7	1	1
R:R:E196	R:R:Q112	15.29	1	Yes	Yes	5	7	1	1
R:R:E196	R:R:I115	2.73	1	Yes	No	5	8	1	2
R:R:L158	R:R:M192	4.24	1	Yes	Yes	5	5	1	1
R:R:H161	R:R:L162	5.14	1	Yes	No	7	4	1	1
R:R:H161	R:R:W188	11.64	1	Yes	No	7	5	1	2
R:R:H161	R:R:H189	3.58	1	Yes	Yes	7	5	1	1
R:R:H189	R:R:S179	5.58	1	Yes	No	5	4	1	1
R:R:F180	R:R:F193	8.57	1	Yes	No	3	6	1	2
R:R:F180	R:R:R251	4.28	1	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	8.57	1	Yes	Yes	3	4	1	2
R:R:H189	R:R:Q187	4.95	1	Yes	Yes	5	2	1	2
R:R:F193	R:R:S247	5.28	1	No	Yes	6	6	2	2
R:R:F193	R:R:F276	4.29	1	No	Yes	6	4	2	2
R:R:L280	R:R:S247	3	0	No	Yes	5	6	1	2
R:R:S247	R:R:T283	3.2	0	Yes	No	6	8	2	2
R:R:F276	R:R:R251	14.97	1	Yes	Yes	4	5	2	2
R:R:D273	R:R:F277	5.97	0	No	Yes	4	5	2	1
R:R:F276	R:R:F277	4.29	1	Yes	Yes	4	5	2	1
R:R:F276	R:R:L280	6.09	1	Yes	No	4	5	2	1
R:R:I154	R:R:L158	1.43	0	No	Yes	5	5	2	1
R:R:L195	R:R:M192	1.41	0	No	Yes	4	5	2	1

Statistics	Value
Average Number Of Links	20.00
Average Number Of Links With An Hub	13.00
Average Interaction Strength	7.59
Average Nodes In Shell	43.00
Average Hubs In Shell	23.00
Average Links In Shell	67.00
Average Links Mediated by Hubs In Shell	66.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IJD

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

3.25

2024-01-03

10.1038/s41421-023-00610-7

A 2D representation of the interactions of FI7 in 8IJD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	10.76	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:W91	3.69	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:L104	5.38	2	Yes	No	0	5	0	1
L:L:?1	R:R:L107	8.96	2	Yes	No	0	6	0	1
L:L:?1	R:R:A108	8.16	2	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.65	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q112	8.62	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:T159	6.68	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:L162	6.27	2	Yes	No	0	4	0	1
L:L:?1	R:R:S179	13.61	2	Yes	No	0	4	0	1
L:L:?1	R:R:F180	15.77	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	5	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	6.41	2	Yes	No	0	5	0	1
L:L:?1	R:R:L280	7.17	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y284	8.35	2	Yes	Yes	0	7	0	1
R:R:R22	R:R:W91	3	0	No	Yes	3	4	2	1
R:R:E37	R:R:Y284	3.37	0	Yes	Yes	7	7	2	1
R:R:C79	R:R:L107	3.17	0	No	No	6	6	2	1
R:R:L83	R:R:N86	5.49	2	Yes	No	6	5	1	2
R:R:L83	R:R:M103	8.48	2	Yes	No	6	5	1	2
R:R:L107	R:R:L83	5.54	2	No	Yes	6	6	1	1
R:R:N86	R:R:W91	9.04	0	No	Yes	5	4	2	1
R:R:W91	R:R:Y87	4.82	2	Yes	Yes	4	6	1	2
R:R:F277	R:R:Y87	3.09	2	No	Yes	5	6	2	2
R:R:L176	R:R:W91	3.42	2	Yes	Yes	4	4	2	1
R:R:F277	R:R:W91	15.03	2	No	Yes	5	4	2	1
R:R:L104	R:R:M167	4.24	2	No	Yes	5	3	1	2
R:R:C177	R:R:L104	3.17	2	Yes	No	9	5	2	1
R:R:F105	R:R:M109	3.73	2	Yes	Yes	6	5	2	2
R:R:F105	R:R:T159	6.49	2	Yes	Yes	6	7	2	1
R:R:A108	R:R:T159	3.36	2	No	Yes	4	7	1	1
R:R:M109	R:R:T155	9.03	2	Yes	No	5	7	2	2
R:R:M109	R:R:T159	6.02	2	Yes	Yes	5	7	2	1
R:R:L280	R:R:R111	3.64	2	Yes	Yes	5	8	1	1
R:R:R111	R:R:T283	11.64	2	Yes	Yes	8	8	1	2
R:R:R111	R:R:Y284	4.12	2	Yes	Yes	8	7	1	1
R:R:Q112	R:R:T155	7.09	0	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	2.66	0	No	Yes	5	7	2	1
R:R:E196	R:R:Q112	8.92	0	No	Yes	5	7	2	1
R:R:L158	R:R:M192	2.83	0	No	No	5	5	2	1
R:R:H161	R:R:L162	10.29	0	No	No	7	4	2	1
R:R:H161	R:R:H189	9.55	0	No	Yes	7	5	2	1
R:R:L162	R:R:M167	4.24	0	No	Yes	4	3	1	2
R:R:C177	R:R:M167	3.24	2	Yes	Yes	9	3	2	2
R:R:F180	R:R:F193	9.65	2	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	7.48	2	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	11.79	2	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	4.87	2	Yes	Yes	3	5	1	1
R:R:H189	R:R:Q187	12.36	2	Yes	Yes	5	2	1	2
R:R:E190	R:R:Q187	10.19	2	Yes	Yes	4	2	2	2
R:R:E190	R:R:H189	12.31	2	Yes	Yes	4	5	2	1
R:R:L195	R:R:M192	5.65	0	No	No	4	5	2	1
R:R:E196	R:R:F193	4.66	0	No	Yes	5	6	2	2
R:R:F193	R:R:R251	5.34	2	Yes	Yes	6	5	2	2
R:R:F276	R:R:R251	13.9	2	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	13.4	2	Yes	Yes	4	5	2	1
R:R:T283	R:R:Y284	4.99	2	Yes	Yes	8	7	2	1
R:R:G113	R:R:Q112	1.64	0	No	Yes	7	7	2	1
R:R:R111	R:R:S114	1.32	2	Yes	No	8	9	1	2

Statistics	Value
Average Number Of Links	15.00
Average Number Of Links With An Hub	9.00
Average Interaction Strength	8.23
Average Nodes In Shell	41.00
Average Hubs In Shell	23.00
Average Links In Shell	59.00
Average Links Mediated by Hubs In Shell	55.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8IYH

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Go/Beta1/Gamma2

3.3

2024-03-06

10.1038/s41467-024-46239-2

A 2D representation of the interactions of FI7 in 8IYH
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	6.18	4	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y87	2.24	4	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	7.06	4	Yes	No	0	6	0	1
L:L:?1	R:R:A108	7.04	4	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.53	4	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q112	6.79	4	Yes	Yes	0	7	0	1
L:L:?1	R:R:T159	6.58	4	Yes	No	0	7	0	1
L:L:?1	R:R:S179	9.58	4	Yes	No	0	4	0	1
L:L:?1	R:R:F180	20.98	4	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	13.94	4	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	6.31	4	Yes	No	0	5	0	1
L:L:?1	R:R:E196	10.99	4	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	5.24	4	Yes	Yes	0	7	0	1
R:R:I26	R:R:L30	5.71	4	Yes	Yes	5	5	2	2
R:R:I26	R:R:Y87	4.84	4	Yes	Yes	5	6	2	1
R:R:I26	R:R:W91	2.35	4	Yes	Yes	5	4	2	2
R:R:L30	R:R:L34	12.46	4	Yes	Yes	5	8	2	2
R:R:L30	R:R:Y87	7.03	4	Yes	Yes	5	6	2	1
R:R:L30	R:R:S281	3	4	Yes	No	5	6	2	2
R:R:L34	R:R:Y87	4.69	4	Yes	Yes	8	6	2	1
R:R:L34	R:R:Y284	2.34	4	Yes	Yes	8	7	2	1
R:R:L107	R:R:L76	4.15	0	No	No	6	7	1	2
R:R:L80	R:R:L83	4.15	4	No	Yes	8	6	2	1
R:R:L80	R:R:Y284	2.34	4	No	Yes	8	7	2	1
R:R:L83	R:R:N86	4.12	4	Yes	No	6	5	1	2
R:R:L83	R:R:Y87	17.58	4	Yes	Yes	6	6	1	1
R:R:L83	R:R:M103	4.24	4	Yes	No	6	5	1	2
R:R:L83	R:R:Y284	3.52	4	Yes	Yes	6	7	1	1
R:R:N86	R:R:W91	9.04	0	No	Yes	5	4	2	2
R:R:W91	R:R:Y87	4.82	4	Yes	Yes	4	6	2	1
R:R:F105	R:R:T159	7.78	4	Yes	No	6	7	2	1
R:R:A108	R:R:T159	3.36	4	No	No	4	7	1	1
R:R:F180	R:R:R111	2.14	4	Yes	Yes	3	8	1	1
R:R:F193	R:R:R111	3.21	4	Yes	Yes	6	8	2	1
R:R:F244	R:R:R111	2.14	4	Yes	Yes	8	8	2	1
R:R:L280	R:R:R111	3.64	4	Yes	Yes	5	8	2	1
R:R:R111	R:R:T283	14.23	4	Yes	Yes	8	8	1	2
R:R:I116	R:R:Q112	5.49	0	No	Yes	5	7	2	1
R:R:Q112	R:R:T155	9.92	4	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	11.98	0	No	Yes	5	7	2	1
R:R:E196	R:R:Q112	6.37	4	No	Yes	5	7	1	1
R:R:H161	R:R:H189	5.97	0	No	Yes	7	5	2	1
R:R:H189	R:R:L162	7.71	4	Yes	No	5	4	1	2
R:R:H189	R:R:S179	4.18	4	Yes	No	5	4	1	1
R:R:F180	R:R:F193	6.43	4	Yes	Yes	3	6	1	2
R:R:F180	R:R:R251	4.28	4	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	12.86	4	Yes	Yes	3	4	1	2
R:R:F180	R:R:L280	3.65	4	Yes	Yes	3	5	1	2
R:R:H189	R:R:Q187	16.07	4	Yes	No	5	2	1	2
R:R:E190	R:R:Q187	2.55	4	Yes	No	4	2	2	2
R:R:M192	R:R:W188	2.33	0	No	No	5	5	1	2
R:R:E190	R:R:H189	3.69	4	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	6.98	4	Yes	Yes	4	5	2	2
R:R:L195	R:R:M192	5.65	0	No	No	4	5	2	1
R:R:F193	R:R:R251	3.21	4	Yes	Yes	6	5	2	2
R:R:F193	R:R:L280	2.44	4	Yes	Yes	6	5	2	2
R:R:F244	R:R:T283	5.19	4	Yes	Yes	8	8	2	2
R:R:F276	R:R:R251	10.69	4	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	7.31	4	Yes	Yes	4	5	2	2
R:R:L280	R:R:T283	2.95	4	Yes	Yes	5	8	2	2
R:R:S281	R:R:Y284	2.54	0	No	Yes	6	7	2	1
R:R:T283	R:R:Y284	4.99	4	Yes	Yes	8	7	2	1

Statistics	Value
Average Number Of Links	13.00
Average Number Of Links With An Hub	7.00
Average Interaction Strength	8.57
Average Nodes In Shell	39.00
Average Hubs In Shell	20.00
Average Links In Shell	62.00
Average Links Mediated by Hubs In Shell	58.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J6I

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.92

2024-04-03

10.1016/j.celrep.2023.113406

A 2D representation of the interactions of FI7 in 8J6I
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	10.6	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y87	2.99	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:L104	8.83	2	Yes	No	0	5	0	1
L:L:?1	R:R:L107	7.95	2	Yes	No	0	6	0	1
L:L:?1	R:R:A108	6.03	2	Yes	No	0	4	0	1
L:L:?1	R:R:R111	8.53	2	Yes	No	0	8	0	1
L:L:?1	R:R:Q112	7.64	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:L158	3.53	2	Yes	No	0	5	0	1
L:L:?1	R:R:T159	2.82	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:H161	4.1	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:L162	7.06	2	Yes	No	0	4	0	1
L:L:?1	R:R:S178	1.92	2	Yes	No	0	4	0	1
L:L:?1	R:R:S179	3.83	2	Yes	No	0	4	0	1
L:L:?1	R:R:F180	17.09	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	12.3	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	2.71	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:E196	5.92	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:F277	3.89	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:L280	5.3	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y284	5.24	2	Yes	Yes	0	7	0	1
R:R:I26	R:R:L30	7.14	2	No	No	5	5	2	2
R:R:I26	R:R:Y87	4.84	2	No	Yes	5	6	2	1
R:R:L30	R:R:L34	2.77	2	No	Yes	5	8	2	2
R:R:L30	R:R:Y87	7.03	2	No	Yes	5	6	2	1
R:R:E37	R:R:L34	3.98	2	Yes	Yes	7	8	2	2
R:R:L34	R:R:Y284	2.34	2	Yes	Yes	8	7	2	1
R:R:E37	R:R:Y284	7.86	2	Yes	Yes	7	7	2	1
R:R:C79	R:R:M103	3.24	2	Yes	Yes	6	5	2	2
R:R:C79	R:R:L107	3.17	2	Yes	No	6	6	2	1
R:R:L83	R:R:Y87	2.34	2	No	Yes	6	6	1	1
R:R:L83	R:R:Y284	2.34	2	No	Yes	6	7	1	1
R:R:W91	R:R:Y87	1.93	2	Yes	Yes	4	6	2	1
R:R:F277	R:R:Y87	2.06	2	Yes	Yes	5	6	1	1
R:R:L104	R:R:M103	7.07	0	No	Yes	5	5	1	2
R:R:F105	R:R:M109	6.22	2	Yes	Yes	6	5	2	2
R:R:F105	R:R:T159	10.38	2	Yes	Yes	6	7	2	1
R:R:M109	R:R:T155	3.01	2	Yes	No	5	7	2	2
R:R:M109	R:R:T159	4.52	2	Yes	Yes	5	7	2	1
R:R:F180	R:R:R111	2.14	2	Yes	No	3	8	1	1
R:R:F193	R:R:R111	4.28	0	No	No	6	8	2	1
R:R:I116	R:R:Q112	2.74	0	No	Yes	5	7	2	1
R:R:Q112	R:R:T155	8.5	2	Yes	No	7	7	1	2
R:R:M192	R:R:Q112	2.72	2	Yes	Yes	5	7	1	1
R:R:E196	R:R:Q112	17.84	2	Yes	Yes	5	7	1	1
R:R:I154	R:R:L158	5.71	0	No	No	5	5	2	1
R:R:T155	R:R:T159	3.14	2	No	Yes	7	7	2	1
R:R:L158	R:R:W188	2.28	0	No	No	5	5	1	2
R:R:H161	R:R:L162	9	2	Yes	No	7	4	1	1
R:R:H161	R:R:W188	12.7	2	Yes	No	7	5	1	2
R:R:H161	R:R:H189	2.39	2	Yes	Yes	7	5	1	1
R:R:F180	R:R:H189	4.53	2	Yes	Yes	3	5	1	1
R:R:F180	R:R:R251	2.14	2	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	7.5	2	Yes	Yes	3	4	1	2
R:R:H189	R:R:Q187	9.89	2	Yes	Yes	5	2	1	2
R:R:E190	R:R:Q187	5.1	2	Yes	Yes	4	2	2	2
R:R:H189	R:R:W188	2.12	2	Yes	No	5	5	1	2
R:R:E190	R:R:H189	12.31	2	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	9.3	2	Yes	Yes	4	5	2	2
R:R:L195	R:R:M192	4.24	0	No	Yes	4	5	2	1
R:R:E196	R:R:M192	10.83	2	Yes	Yes	5	5	1	1
R:R:E196	R:R:F193	4.66	2	Yes	No	5	6	1	2
R:R:F193	R:R:S247	2.64	0	No	No	6	6	2	2
R:R:F276	R:R:S247	3.96	2	Yes	No	4	6	2	2
R:R:L280	R:R:S247	3	2	Yes	No	5	6	1	2
R:R:F276	R:R:R251	14.97	2	Yes	Yes	4	5	2	2
R:R:D273	R:R:F277	9.55	0	No	Yes	4	5	2	1
R:R:F276	R:R:F277	4.29	2	Yes	Yes	4	5	2	1
R:R:F276	R:R:L280	4.87	2	Yes	Yes	4	5	2	1
R:R:L280	R:R:Y284	2.34	2	Yes	Yes	5	7	1	1

Statistics	Value
Average Number Of Links	20.00
Average Number Of Links With An Hub	11.00
Average Interaction Strength	6.41
Average Nodes In Shell	42.00
Average Hubs In Shell	23.00
Average Links In Shell	69.00
Average Links Mediated by Hubs In Shell	64.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8J6R

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.76

2023-12-06

10.1038/s41467-023-43537-z

A 2D representation of the interactions of FI7 in 8J6R
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:I26	R:R:L30	7.14	3	Yes	Yes	5	5	2	2
R:R:I26	R:R:Y87	3.63	3	Yes	Yes	5	6	2	1
R:R:F277	R:R:I26	3.77	3	Yes	Yes	5	5	2	2
R:R:L30	R:R:Y87	7.03	3	Yes	Yes	5	6	2	1
R:R:P31	R:R:Y87	2.78	0	No	Yes	6	6	2	1
R:R:E37	R:R:Y284	4.49	3	Yes	No	7	7	2	1
R:R:L107	R:R:L76	2.77	3	Yes	No	6	7	1	2
R:R:C79	R:R:L107	3.17	0	No	Yes	6	6	2	1
R:R:L83	R:R:Y87	4.69	3	Yes	Yes	6	6	2	1
R:R:L83	R:R:M103	2.83	3	Yes	Yes	6	5	2	2
R:R:L107	R:R:L83	4.15	3	Yes	Yes	6	6	1	2
R:R:L83	R:R:Y284	5.86	3	Yes	No	6	7	2	1
R:R:N86	R:R:W91	6.78	3	No	Yes	5	4	2	1
R:R:W91	R:R:Y87	4.82	3	Yes	Yes	4	6	1	1
R:R:F277	R:R:Y87	3.09	3	Yes	Yes	5	6	2	1
L:L:?1	R:R:Y87	4.55	3	Yes	Yes	0	6	0	1
R:R:S178	R:R:W91	6.18	3	No	Yes	4	4	1	1
R:R:F277	R:R:W91	16.04	3	Yes	Yes	5	4	2	1
L:L:?1	R:R:W91	2.95	3	Yes	Yes	0	4	0	1
R:R:L104	R:R:M103	2.83	0	No	Yes	5	5	1	2
R:R:L107	R:R:M103	2.83	3	Yes	Yes	6	5	1	2
L:L:?1	R:R:L104	9.86	3	Yes	No	0	5	0	1
L:L:?1	R:R:L107	8.07	3	Yes	Yes	0	6	0	1
L:L:?1	R:R:A108	6.12	3	Yes	No	0	4	0	1
R:R:F244	R:R:R111	3.21	3	Yes	No	8	8	2	1
R:R:R111	R:R:T283	6.47	3	No	No	8	8	1	2
L:L:?1	R:R:R111	8.65	3	Yes	No	0	8	0	1
R:R:Q112	R:R:T155	2.83	3	Yes	Yes	7	7	1	2
R:R:L158	R:R:Q112	5.32	3	No	Yes	5	7	1	1
R:R:M192	R:R:Q112	2.72	3	Yes	Yes	5	7	1	1
R:R:E196	R:R:Q112	5.1	0	No	Yes	5	7	2	1
L:L:?1	R:R:Q112	8.62	3	Yes	Yes	0	7	0	1
R:R:L158	R:R:M192	4.24	3	No	Yes	5	5	1	1
L:L:?1	R:R:L158	5.38	3	Yes	No	0	5	0	1
R:R:H161	R:R:L162	5.14	3	Yes	No	7	4	1	1
R:R:H161	R:R:W188	11.64	3	Yes	No	7	5	1	2
R:R:H161	R:R:H189	7.17	3	Yes	No	7	5	1	1
L:L:?1	R:R:H161	9.16	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:L162	8.96	3	Yes	No	0	4	0	1
L:L:?1	R:R:S178	7.78	3	Yes	No	0	4	0	1
L:L:?1	R:R:S179	9.72	3	Yes	No	0	4	0	1
R:R:F180	R:R:R251	5.34	3	No	Yes	3	5	1	2
R:R:F180	R:R:F276	17.15	3	No	Yes	3	4	1	2
L:L:?1	R:R:F180	13.41	3	Yes	No	0	3	0	1
R:R:H189	R:R:Q187	11.13	3	No	No	5	2	1	2
R:R:M192	R:R:W188	4.65	3	Yes	No	5	5	1	2
L:L:?1	R:R:H189	12.49	3	Yes	No	0	5	0	1
L:L:?1	R:R:M192	6.41	3	Yes	Yes	0	5	0	1
R:R:F244	R:R:T283	7.78	3	Yes	No	8	8	2	2
R:R:F276	R:R:R251	12.83	3	Yes	Yes	4	5	2	2
R:R:F276	R:R:L280	6.09	3	Yes	No	4	5	2	1
R:R:L280	R:R:T283	2.95	0	No	No	5	8	1	2
L:L:?1	R:R:L280	7.17	3	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	7.59	3	Yes	No	0	7	0	1
R:R:R22	R:R:W91	2	0	Yes	Yes	3	4	2	1

Statistics	Value
Average Number Of Links	17.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	8.05
Average Nodes In Shell	37.00
Average Hubs In Shell	18.00
Average Links In Shell	55.00
Average Links Mediated by Hubs In Shell	52.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

8JZ7

Alicarboxylic acid

Hydroxycarboxylic Acid

HCA2

Homo Sapiens

MK6892

Gi1/Beta1/Gamma2

2.6

2023-10-04

10.1038/s41392-023-01625-y

A 2D representation of the interactions of FI7 in 8JZ7
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L83	2.65	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:L107	9.71	2	Yes	No	0	6	0	1
L:L:?1	R:R:A108	6.03	2	Yes	No	0	4	0	1
L:L:?1	R:R:R111	6.98	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Q112	6.79	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:T159	2.82	2	Yes	No	0	7	0	1
L:L:?1	R:R:L162	5.3	2	Yes	No	0	4	0	1
L:L:?1	R:R:S178	4.79	2	Yes	No	0	4	0	1
L:L:?1	R:R:S179	5.75	2	Yes	No	0	4	0	1
L:L:?1	R:R:F180	18.65	2	Yes	Yes	0	3	0	1
L:L:?1	R:R:H189	16.4	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:M192	5.41	2	Yes	No	0	5	0	1
L:L:?1	R:R:L280	4.42	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	5.98	2	Yes	Yes	0	7	0	1
R:R:L34	R:R:L80	2.77	2	Yes	No	8	8	2	2
R:R:L34	R:R:L83	2.77	2	Yes	Yes	8	6	2	1
R:R:L34	R:R:Y284	5.86	2	Yes	Yes	8	7	2	1
R:R:E37	R:R:Y284	4.49	0	No	Yes	7	7	2	1
R:R:L107	R:R:L76	2.77	0	No	No	6	7	1	2
R:R:C79	R:R:M103	4.86	0	No	Yes	6	5	2	2
R:R:C79	R:R:L107	6.35	0	No	No	6	6	2	1
R:R:L80	R:R:Y284	2.34	2	No	Yes	8	7	2	1
R:R:L83	R:R:N86	2.75	2	Yes	No	6	5	1	2
R:R:L83	R:R:Y87	9.38	2	Yes	Yes	6	6	1	2
R:R:L83	R:R:M103	2.83	2	Yes	Yes	6	5	1	2
R:R:L83	R:R:Y284	3.52	2	Yes	Yes	6	7	1	1
R:R:F105	R:R:M109	6.22	2	Yes	Yes	6	5	2	2
R:R:F105	R:R:T159	6.49	2	Yes	No	6	7	2	1
R:R:M109	R:R:T155	4.52	2	Yes	No	5	7	2	2
R:R:M109	R:R:T159	7.53	2	Yes	No	5	7	2	1
R:R:L280	R:R:R111	2.43	2	No	Yes	5	8	1	1
R:R:R111	R:R:T283	7.76	2	Yes	No	8	8	1	2
R:R:R111	R:R:Y284	5.14	2	Yes	Yes	8	7	1	1
R:R:Q112	R:R:T155	2.83	0	Yes	No	7	7	1	2
R:R:L158	R:R:Q112	2.66	0	No	Yes	5	7	2	1
R:R:E196	R:R:Q112	5.1	0	No	Yes	5	7	2	1
R:R:H161	R:R:L162	6.43	0	No	No	7	4	2	1
R:R:H161	R:R:W188	8.46	0	No	No	7	5	2	2
R:R:H189	R:R:S179	5.58	2	Yes	No	5	4	1	1
R:R:E190	R:R:F180	7	2	Yes	Yes	4	3	2	1
R:R:F180	R:R:F193	3.22	2	Yes	No	3	6	1	2
R:R:F180	R:R:R251	5.34	2	Yes	Yes	3	5	1	2
R:R:F180	R:R:F276	4.29	2	Yes	No	3	4	1	2
R:R:H189	R:R:Q187	9.89	2	Yes	No	5	2	1	2
R:R:M192	R:R:W188	4.65	0	No	No	5	5	1	2
R:R:E190	R:R:H189	2.46	2	Yes	Yes	4	5	2	1
R:R:E190	R:R:R251	11.63	2	Yes	Yes	4	5	2	2
R:R:E196	R:R:F193	5.83	0	No	No	5	6	2	2
R:R:F276	R:R:R251	21.38	2	No	Yes	4	5	2	2
R:R:L280	R:R:Y284	2.34	2	No	Yes	5	7	1	1
R:R:S178	R:R:S181	1.63	0	No	No	4	4	1	2

Statistics	Value
Average Number Of Links	14.00
Average Number Of Links With An Hub	6.00
Average Interaction Strength	7.26
Average Nodes In Shell	37.00
Average Hubs In Shell	14.00
Average Links In Shell	51.00
Average Links Mediated by Hubs In Shell	44.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	15.86
Average Number Of Links With An Hub	6.07
Average Interaction Strength	7.83
Average Nodes In Shell	36.29
Average Hubs In Shell	15.14
Average Links In Shell	51.21
Average Links Mediated by Hubs In Shell	45.43

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)