Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7XK2 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 3.1 | 2023-02-22 | 10.1038/s41467-023-37177-6 |
![](/psngpcr/ligands/FI7/FI7_7XK2_L_L_1.png)
A 2D representation of the interactions of FI7 in 7XK2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E37 | R:R:Y284 | 7.86 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L83 | R:R:Y284 | 5.86 | 5 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 3.69 | 5 | Yes | No | 0 | 6 | 0 | 1 | R:R:W91 | R:R:Y87 | 16.4 | 5 | Yes | No | 4 | 6 | 2 | 2 | R:R:F277 | R:R:Y87 | 4.13 | 5 | Yes | No | 5 | 6 | 1 | 2 | R:R:F277 | R:R:W91 | 4.01 | 5 | Yes | Yes | 5 | 4 | 1 | 2 | L:L:?1 | R:R:L104 | 4.61 | 5 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L107 | 19.35 | 5 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A108 | 5.24 | 5 | Yes | No | 0 | 4 | 0 | 1 | R:R:F193 | R:R:R111 | 4.28 | 0 | No | Yes | 6 | 8 | 2 | 1 | R:R:F244 | R:R:R111 | 4.28 | 5 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:R111 | R:R:T283 | 5.17 | 5 | Yes | No | 8 | 8 | 1 | 2 | L:L:?1 | R:R:R111 | 4.85 | 5 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:Q112 | R:R:T155 | 4.25 | 0 | No | No | 7 | 7 | 1 | 2 | R:R:E196 | R:R:Q112 | 16.57 | 0 | No | No | 5 | 7 | 2 | 1 | L:L:?1 | R:R:Q112 | 6.2 | 5 | Yes | No | 0 | 7 | 0 | 1 | R:R:L158 | R:R:M192 | 4.24 | 5 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:L158 | 3.69 | 5 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L162 | 10.14 | 5 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S179 | 6 | 5 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:R251 | 10.69 | 5 | No | No | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 8.57 | 5 | No | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 14.6 | 5 | Yes | No | 0 | 3 | 0 | 1 | R:R:M192 | R:R:W188 | 9.31 | 5 | No | No | 5 | 5 | 1 | 2 | R:R:E190 | R:R:H189 | 19.69 | 0 | No | No | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 16.26 | 5 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:M192 | 7.53 | 5 | Yes | No | 0 | 5 | 0 | 1 | R:R:E196 | R:R:F193 | 5.83 | 0 | No | No | 5 | 6 | 2 | 2 | R:R:F244 | R:R:T283 | 7.78 | 5 | Yes | No | 8 | 8 | 2 | 2 | R:R:F276 | R:R:R251 | 11.76 | 5 | Yes | No | 4 | 5 | 2 | 2 | R:R:D273 | R:R:F277 | 4.78 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:L280 | 8.53 | 5 | Yes | No | 4 | 5 | 2 | 1 | R:R:F277 | R:R:L280 | 3.65 | 5 | Yes | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:F277 | 4.05 | 5 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L280 | 8.29 | 5 | Yes | No | 0 | 5 | 0 | 1 | R:R:S281 | R:R:Y284 | 3.82 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:T283 | R:R:Y284 | 3.75 | 5 | No | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 4.68 | 5 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 7.95 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/FI7/FI7_7XK2_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_7XK2_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IHF | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 2.97 | 2023-08-30 | 10.1038/s41467-023-41650-7 |
![](/psngpcr/ligands/FI7/FI7_8IHF_L_L_1.png)
A 2D representation of the interactions of FI7 in 8IHF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:E37 | R:R:L34 | 3.98 | 1 | No | No | 7 | 8 | 2 | 2 | R:R:L34 | R:R:Y284 | 5.86 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:Y284 | 6.73 | 1 | No | Yes | 7 | 7 | 2 | 1 | R:R:L80 | R:R:Y284 | 4.69 | 0 | No | Yes | 8 | 7 | 2 | 1 | R:R:L83 | R:R:Y87 | 5.86 | 1 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:L83 | R:R:M103 | 4.24 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:L107 | R:R:L83 | 6.92 | 1 | No | Yes | 6 | 6 | 1 | 1 | L:L:?1 | R:R:L83 | 4.61 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:W91 | 10.17 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:W91 | R:R:Y87 | 8.68 | 1 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:S178 | R:R:W91 | 6.18 | 1 | No | Yes | 4 | 4 | 1 | 1 | R:R:F277 | R:R:W91 | 10.02 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | L:L:?1 | R:R:W91 | 3.03 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:C177 | R:R:L104 | 4.76 | 30 | No | No | 9 | 5 | 2 | 1 | L:L:?1 | R:R:L104 | 7.37 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F105 | R:R:M109 | 8.71 | 1 | No | Yes | 6 | 5 | 2 | 2 | R:R:F105 | R:R:T159 | 6.49 | 1 | No | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:L107 | 10.14 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:A108 | R:R:T159 | 3.36 | 1 | No | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:A108 | 7.34 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:M109 | R:R:T159 | 3.01 | 1 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:E196 | R:R:R111 | 3.49 | 1 | No | No | 5 | 8 | 1 | 1 | R:R:R111 | R:R:T283 | 6.47 | 1 | No | No | 8 | 8 | 1 | 2 | L:L:?1 | R:R:R111 | 9.71 | 1 | Yes | No | 0 | 8 | 0 | 1 | R:R:L158 | R:R:Q112 | 5.32 | 1 | Yes | No | 5 | 7 | 1 | 1 | R:R:E196 | R:R:Q112 | 15.29 | 1 | No | No | 5 | 7 | 1 | 1 | L:L:?1 | R:R:Q112 | 8.86 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:L158 | R:R:M192 | 4.24 | 1 | Yes | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:L158 | 3.69 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T159 | 5.89 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:H161 | R:R:L162 | 5.14 | 1 | Yes | No | 7 | 4 | 1 | 1 | R:R:H161 | R:R:W188 | 11.64 | 1 | Yes | No | 7 | 5 | 1 | 2 | R:R:H161 | R:R:H189 | 3.58 | 1 | Yes | Yes | 7 | 5 | 1 | 1 | L:L:?1 | R:R:H161 | 3.42 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:L162 | 8.29 | 1 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S178 | 4 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:H189 | R:R:S179 | 5.58 | 1 | Yes | No | 5 | 4 | 1 | 1 | L:L:?1 | R:R:S179 | 10 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:F193 | 8.57 | 1 | Yes | No | 3 | 6 | 1 | 2 | R:R:F180 | R:R:R251 | 4.28 | 1 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 8.57 | 1 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 21.08 | 1 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 4.95 | 1 | Yes | No | 5 | 2 | 1 | 2 | L:L:?1 | R:R:H189 | 16.26 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:M192 | 10.35 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F193 | R:R:F276 | 4.29 | 1 | No | Yes | 6 | 4 | 2 | 2 | L:L:?1 | R:R:E196 | 4.41 | 1 | Yes | No | 0 | 5 | 0 | 1 | R:R:F276 | R:R:R251 | 14.97 | 1 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:D273 | R:R:F277 | 5.97 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:F277 | 4.29 | 1 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:L280 | 6.09 | 1 | Yes | No | 4 | 5 | 2 | 1 | L:L:?1 | R:R:F277 | 4.05 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L280 | 6.45 | 1 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y284 | 7.02 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:R22 | R:R:W91 | 3 | 1 | Yes | Yes | 3 | 4 | 2 | 1 | R:R:I154 | R:R:L158 | 1.43 | 0 | No | Yes | 5 | 5 | 2 | 1 | R:R:L195 | R:R:M192 | 1.41 | 0 | No | No | 4 | 5 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 20.00 | Average Number Of Links With An Hub | 9.00 | Average Interaction Strength | 7.80 | Average Nodes In Shell | 40.00 | Average Hubs In Shell | 15.00 | Average Links In Shell | 57.00 | Average Links Mediated by Hubs In Shell | 51.00 |
| ![](/psngpcr/ligands/FI7/FI7_8IHF_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8IHF_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IJD | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 3.25 | 2024-01-03 | 10.1038/s41421-023-00610-7 |
![](/psngpcr/ligands/FI7/FI7_8IJD_L_L_1.png)
A 2D representation of the interactions of FI7 in 8IJD colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:R22 | R:R:W91 | 4 | 0 | No | Yes | 3 | 4 | 2 | 1 | R:R:E37 | R:R:L34 | 9.28 | 2 | Yes | No | 7 | 8 | 2 | 2 | R:R:L34 | R:R:Y284 | 7.03 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:Y284 | 4.49 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:L83 | R:R:Y87 | 3.52 | 0 | No | Yes | 6 | 6 | 2 | 2 | R:R:L107 | R:R:L83 | 2.77 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:N86 | R:R:W91 | 9.04 | 0 | No | Yes | 5 | 4 | 2 | 1 | R:R:W91 | R:R:Y87 | 4.82 | 2 | Yes | Yes | 4 | 6 | 1 | 2 | R:R:F277 | R:R:Y87 | 3.09 | 2 | No | Yes | 5 | 6 | 2 | 2 | R:R:L176 | R:R:W91 | 3.42 | 2 | Yes | Yes | 4 | 4 | 2 | 1 | R:R:F277 | R:R:W91 | 15.03 | 2 | No | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:W91 | 3.79 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:L104 | R:R:M167 | 5.65 | 2 | No | Yes | 5 | 3 | 1 | 2 | R:R:C177 | R:R:L104 | 3.17 | 2 | Yes | No | 9 | 5 | 2 | 1 | L:L:?1 | R:R:L104 | 5.53 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F105 | R:R:M109 | 3.73 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F105 | R:R:T159 | 6.49 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:L107 | 9.21 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:A108 | R:R:T159 | 3.36 | 2 | No | Yes | 4 | 7 | 1 | 1 | L:L:?1 | R:R:A108 | 8.39 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:M109 | R:R:T155 | 9.03 | 2 | Yes | No | 5 | 7 | 2 | 2 | R:R:M109 | R:R:T159 | 6.02 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:L280 | R:R:R111 | 3.64 | 2 | Yes | Yes | 5 | 8 | 1 | 1 | R:R:R111 | R:R:T283 | 11.64 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:R111 | R:R:Y284 | 4.12 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:R111 | 8.9 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:Q112 | R:R:T155 | 7.09 | 0 | Yes | No | 7 | 7 | 1 | 2 | R:R:L158 | R:R:Q112 | 2.66 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:E196 | R:R:Q112 | 8.92 | 0 | No | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:Q112 | 8.86 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L158 | R:R:M192 | 2.83 | 0 | No | No | 5 | 5 | 2 | 1 | L:L:?1 | R:R:T159 | 6.87 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:H161 | R:R:L162 | 10.29 | 0 | No | No | 7 | 4 | 2 | 1 | R:R:H161 | R:R:H189 | 9.55 | 0 | No | Yes | 7 | 5 | 2 | 1 | L:L:?1 | R:R:L162 | 6.45 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:C177 | R:R:M167 | 6.48 | 2 | Yes | Yes | 9 | 3 | 2 | 2 | L:L:?1 | R:R:S179 | 13.99 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:F193 | 9.65 | 2 | Yes | Yes | 3 | 6 | 1 | 2 | R:R:F180 | R:R:R251 | 7.48 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 11.79 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | R:R:F180 | R:R:L280 | 4.87 | 2 | Yes | Yes | 3 | 5 | 1 | 1 | L:L:?1 | R:R:F180 | 16.22 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 12.36 | 2 | Yes | No | 5 | 2 | 1 | 2 | R:R:E190 | R:R:Q187 | 10.19 | 2 | Yes | No | 4 | 2 | 2 | 2 | R:R:E190 | R:R:H189 | 12.31 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 5.14 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L195 | R:R:M192 | 4.24 | 0 | No | No | 4 | 5 | 2 | 1 | L:L:?1 | R:R:M192 | 4.71 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:E196 | R:R:F193 | 4.66 | 0 | No | Yes | 5 | 6 | 2 | 2 | R:R:F193 | R:R:R251 | 5.34 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F276 | R:R:R251 | 13.9 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:F276 | R:R:L280 | 13.4 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:L280 | 7.37 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:T283 | R:R:Y284 | 4.99 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 8.59 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:G113 | R:R:Q112 | 1.64 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:R111 | R:R:S114 | 1.32 | 2 | Yes | No | 8 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 8.00 | Average Interaction Strength | 8.14 | Average Nodes In Shell | 41.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 58.00 | Average Links Mediated by Hubs In Shell | 53.00 |
| ![](/psngpcr/ligands/FI7/FI7_8IJD_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8IJD_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8IYH | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Go/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41467-024-46239-2 |
![](/psngpcr/ligands/FI7/FI7_8IYH_L_L_1.png)
A 2D representation of the interactions of FI7 in 8IYH colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L30 | R:R:L34 | 12.46 | 3 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:L30 | R:R:Y87 | 7.03 | 3 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:L30 | R:R:S281 | 3 | 3 | Yes | No | 5 | 6 | 2 | 2 | R:R:L34 | R:R:Y87 | 3.52 | 3 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:L34 | R:R:Y284 | 2.34 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:S281 | 4.31 | 3 | Yes | No | 7 | 6 | 2 | 2 | R:R:E37 | R:R:Y284 | 4.49 | 3 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:L107 | R:R:L76 | 4.15 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:L80 | R:R:L83 | 4.15 | 3 | No | Yes | 8 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 2.34 | 3 | No | Yes | 8 | 7 | 2 | 1 | R:R:L83 | R:R:N86 | 4.12 | 3 | Yes | No | 6 | 5 | 1 | 2 | R:R:L83 | R:R:Y87 | 17.58 | 3 | Yes | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:M103 | 4.24 | 3 | Yes | No | 6 | 5 | 1 | 2 | R:R:L83 | R:R:Y284 | 3.52 | 3 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 6.45 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:N86 | R:R:W91 | 9.04 | 0 | No | Yes | 5 | 4 | 2 | 2 | R:R:W91 | R:R:Y87 | 4.82 | 0 | Yes | Yes | 4 | 6 | 2 | 1 | L:L:?1 | R:R:Y87 | 2.34 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L104 | R:R:M167 | 2.83 | 0 | No | Yes | 5 | 3 | 1 | 2 | L:L:?1 | R:R:L104 | 1.84 | 3 | Yes | No | 0 | 5 | 0 | 1 | R:R:F105 | R:R:T159 | 7.78 | 3 | Yes | No | 6 | 7 | 2 | 1 | L:L:?1 | R:R:L107 | 7.37 | 3 | Yes | No | 0 | 6 | 0 | 1 | R:R:A108 | R:R:T159 | 3.36 | 3 | No | No | 4 | 7 | 1 | 1 | L:L:?1 | R:R:A108 | 7.34 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:R111 | 2.14 | 3 | Yes | Yes | 3 | 8 | 1 | 1 | R:R:F193 | R:R:R111 | 3.21 | 3 | Yes | Yes | 6 | 8 | 2 | 1 | R:R:F244 | R:R:R111 | 2.14 | 3 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:L280 | R:R:R111 | 3.64 | 3 | Yes | Yes | 5 | 8 | 2 | 1 | R:R:R111 | R:R:T283 | 14.23 | 3 | Yes | Yes | 8 | 8 | 1 | 2 | L:L:?1 | R:R:R111 | 8.9 | 3 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:I116 | R:R:Q112 | 5.49 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:Q112 | R:R:T155 | 9.92 | 3 | Yes | No | 7 | 7 | 1 | 2 | R:R:L158 | R:R:Q112 | 13.31 | 3 | No | Yes | 5 | 7 | 1 | 1 | R:R:E196 | R:R:Q112 | 14.02 | 3 | No | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:Q112 | 7.09 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:E196 | R:R:I115 | 2.73 | 3 | No | Yes | 5 | 8 | 1 | 2 | R:R:F244 | R:R:I115 | 8.79 | 3 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:L158 | R:R:M192 | 8.48 | 3 | No | No | 5 | 5 | 1 | 1 | L:L:?1 | R:R:L158 | 5.53 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T159 | 6.87 | 3 | Yes | No | 0 | 7 | 0 | 1 | R:R:H161 | R:R:H189 | 5.97 | 0 | No | Yes | 7 | 5 | 2 | 1 | R:R:L162 | R:R:S179 | 3 | 3 | No | No | 4 | 4 | 1 | 1 | R:R:H189 | R:R:L162 | 10.29 | 3 | Yes | No | 5 | 4 | 1 | 1 | L:L:?1 | R:R:L162 | 2.76 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:K165 | R:R:M167 | 2.88 | 0 | No | Yes | 4 | 3 | 2 | 2 | R:R:H189 | R:R:K165 | 3.93 | 3 | Yes | No | 5 | 4 | 1 | 2 | R:R:H189 | R:R:S179 | 4.18 | 3 | Yes | No | 5 | 4 | 1 | 1 | L:L:?1 | R:R:S179 | 10 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:F193 | 6.43 | 3 | Yes | Yes | 3 | 6 | 1 | 2 | R:R:F180 | R:R:R251 | 4.28 | 3 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 12.86 | 3 | Yes | Yes | 3 | 4 | 1 | 2 | R:R:F180 | R:R:L280 | 3.65 | 3 | Yes | Yes | 3 | 5 | 1 | 2 | L:L:?1 | R:R:F180 | 21.89 | 3 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 6.18 | 3 | Yes | No | 5 | 2 | 1 | 2 | R:R:E190 | R:R:Q187 | 6.37 | 3 | Yes | No | 4 | 2 | 2 | 2 | R:R:E190 | R:R:H189 | 3.69 | 3 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 14.55 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E190 | R:R:R251 | 5.82 | 3 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:L195 | R:R:M192 | 5.65 | 0 | No | No | 4 | 5 | 2 | 1 | L:L:?1 | R:R:M192 | 6.59 | 3 | Yes | No | 0 | 5 | 0 | 1 | R:R:F193 | R:R:R251 | 3.21 | 3 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F193 | R:R:L280 | 2.44 | 3 | Yes | Yes | 6 | 5 | 2 | 2 | L:L:?1 | R:R:E196 | 8.82 | 3 | Yes | No | 0 | 5 | 0 | 1 | R:R:F244 | R:R:T283 | 5.19 | 3 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F276 | R:R:R251 | 10.69 | 3 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:F276 | R:R:L280 | 7.31 | 3 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:L280 | R:R:T283 | 2.95 | 3 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:S281 | R:R:Y284 | 2.54 | 3 | No | Yes | 6 | 7 | 2 | 1 | R:R:T283 | R:R:Y284 | 4.99 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | L:L:?1 | R:R:Y284 | 5.46 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 16.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 7.74 | Average Nodes In Shell | 42.00 | Average Hubs In Shell | 22.00 | Average Links In Shell | 70.00 | Average Links Mediated by Hubs In Shell | 65.00 |
| ![](/psngpcr/ligands/FI7/FI7_8IYH_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8IYH_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8J6I | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 2.92 | 2024-04-03 | 10.1016/j.celrep.2023.113406 |
![](/psngpcr/ligands/FI7/FI7_8J6I_L_L_1.png)
A 2D representation of the interactions of FI7 in 8J6I colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I26 | R:R:L30 | 7.14 | 2 | No | No | 5 | 5 | 2 | 2 | R:R:I26 | R:R:Y87 | 4.84 | 2 | No | Yes | 5 | 6 | 2 | 1 | R:R:L30 | R:R:L34 | 2.77 | 2 | No | Yes | 5 | 8 | 2 | 2 | R:R:L30 | R:R:Y87 | 7.03 | 2 | No | Yes | 5 | 6 | 2 | 1 | R:R:E37 | R:R:L34 | 3.98 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:L34 | R:R:Y284 | 2.34 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:Y284 | 7.86 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:C79 | R:R:M103 | 3.24 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:C79 | R:R:L107 | 3.17 | 2 | Yes | No | 6 | 6 | 2 | 1 | R:R:L83 | R:R:Y87 | 2.34 | 2 | No | Yes | 6 | 6 | 1 | 1 | R:R:L83 | R:R:Y284 | 2.34 | 2 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 11.06 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:W91 | R:R:Y87 | 1.93 | 2 | Yes | Yes | 4 | 6 | 2 | 1 | R:R:F277 | R:R:Y87 | 2.06 | 2 | Yes | Yes | 5 | 6 | 1 | 1 | L:L:?1 | R:R:Y87 | 3.12 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L104 | R:R:M103 | 7.07 | 0 | No | Yes | 5 | 5 | 1 | 2 | L:L:?1 | R:R:L104 | 9.21 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:F105 | R:R:M109 | 6.22 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F105 | R:R:T159 | 10.38 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | L:L:?1 | R:R:L107 | 8.29 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A108 | 6.29 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:M109 | R:R:T155 | 3.01 | 2 | Yes | No | 5 | 7 | 2 | 2 | R:R:M109 | R:R:T159 | 4.52 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F180 | R:R:R111 | 2.14 | 2 | Yes | No | 3 | 8 | 1 | 1 | R:R:F193 | R:R:R111 | 4.28 | 0 | No | No | 6 | 8 | 2 | 1 | L:L:?1 | R:R:R111 | 8.9 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:I116 | R:R:Q112 | 2.74 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:Q112 | R:R:T155 | 8.5 | 2 | Yes | No | 7 | 7 | 1 | 2 | R:R:E196 | R:R:Q112 | 17.84 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:Q112 | 7.98 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I154 | R:R:L158 | 5.71 | 0 | No | Yes | 5 | 5 | 2 | 1 | R:R:T155 | R:R:T159 | 3.14 | 2 | No | Yes | 7 | 7 | 2 | 1 | R:R:L158 | R:R:W188 | 2.28 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:L158 | R:R:M192 | 8.48 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?1 | R:R:L158 | 3.69 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:T159 | 2.94 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:H161 | R:R:L162 | 9 | 2 | Yes | No | 7 | 4 | 1 | 1 | R:R:H161 | R:R:W188 | 12.7 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:H161 | R:R:H189 | 2.39 | 2 | Yes | Yes | 7 | 5 | 1 | 1 | L:L:?1 | R:R:H161 | 4.28 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:L162 | 7.37 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S178 | 2 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S179 | 4 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:H189 | 4.53 | 2 | Yes | Yes | 3 | 5 | 1 | 1 | R:R:F180 | R:R:R251 | 2.14 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 7.5 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 17.84 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 9.89 | 2 | Yes | Yes | 5 | 2 | 1 | 2 | R:R:E190 | R:R:Q187 | 5.1 | 2 | Yes | Yes | 4 | 2 | 2 | 2 | R:R:H189 | R:R:W188 | 2.12 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:M192 | R:R:W188 | 3.49 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | R:R:E190 | R:R:H189 | 12.31 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 12.84 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E190 | R:R:R251 | 9.3 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:E196 | R:R:M192 | 6.77 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?1 | R:R:M192 | 6.59 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E196 | R:R:F193 | 4.66 | 2 | Yes | No | 5 | 6 | 1 | 2 | R:R:F193 | R:R:S247 | 2.64 | 0 | No | No | 6 | 6 | 2 | 2 | L:L:?1 | R:R:E196 | 6.18 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F276 | R:R:S247 | 3.96 | 2 | Yes | No | 4 | 6 | 2 | 2 | R:R:L280 | R:R:S247 | 3 | 2 | Yes | No | 5 | 6 | 1 | 2 | R:R:F276 | R:R:R251 | 14.97 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:D273 | R:R:F277 | 9.55 | 0 | No | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:F277 | 4.29 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:F276 | R:R:L280 | 4.87 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:F277 | 4.05 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:L280 | R:R:Y284 | 2.34 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:L280 | 5.53 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y284 | 5.46 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:E196 | R:R:L195 | 1.33 | 2 | Yes | No | 5 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 20.00 | Average Number Of Links With An Hub | 12.00 | Average Interaction Strength | 6.88 | Average Nodes In Shell | 42.00 | Average Hubs In Shell | 25.00 | Average Links In Shell | 70.00 | Average Links Mediated by Hubs In Shell | 67.00 |
| ![](/psngpcr/ligands/FI7/FI7_8J6I_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8J6I_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8J6R | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 2.76 | 2023-12-06 | 10.1038/s41467-023-43537-z |
![](/psngpcr/ligands/FI7/FI7_8J6R_L_L_1.png)
A 2D representation of the interactions of FI7 in 8J6R colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:I26 | R:R:L30 | 7.14 | 3 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:I26 | R:R:Y87 | 3.63 | 3 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:F277 | R:R:I26 | 3.77 | 3 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:L30 | R:R:Y87 | 7.03 | 3 | Yes | Yes | 5 | 6 | 2 | 1 | R:R:P31 | R:R:Y87 | 2.78 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:E37 | R:R:Y284 | 4.49 | 3 | Yes | No | 7 | 7 | 2 | 1 | R:R:L107 | R:R:L76 | 2.77 | 3 | Yes | No | 6 | 7 | 1 | 2 | R:R:C79 | R:R:L107 | 3.17 | 0 | No | Yes | 6 | 6 | 2 | 1 | R:R:L83 | R:R:Y87 | 4.69 | 3 | Yes | Yes | 6 | 6 | 2 | 1 | R:R:L83 | R:R:M103 | 2.83 | 3 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:L107 | R:R:L83 | 4.15 | 3 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:L83 | R:R:Y284 | 5.86 | 3 | Yes | No | 6 | 7 | 2 | 1 | R:R:N86 | R:R:W91 | 6.78 | 3 | No | Yes | 5 | 4 | 2 | 1 | R:R:W91 | R:R:Y87 | 4.82 | 3 | Yes | Yes | 4 | 6 | 1 | 1 | R:R:F277 | R:R:Y87 | 3.09 | 3 | Yes | Yes | 5 | 6 | 2 | 1 | L:L:?1 | R:R:Y87 | 4.68 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:S178 | R:R:W91 | 6.18 | 3 | No | Yes | 4 | 4 | 1 | 1 | R:R:F277 | R:R:W91 | 16.04 | 3 | Yes | Yes | 5 | 4 | 2 | 1 | L:L:?1 | R:R:W91 | 3.03 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | R:R:L104 | R:R:M103 | 2.83 | 0 | No | Yes | 5 | 5 | 1 | 2 | R:R:L107 | R:R:M103 | 2.83 | 3 | Yes | Yes | 6 | 5 | 1 | 2 | L:L:?1 | R:R:L104 | 10.14 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:L107 | 8.29 | 3 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A108 | 6.29 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:F244 | R:R:R111 | 3.21 | 3 | Yes | No | 8 | 8 | 2 | 1 | R:R:R111 | R:R:T283 | 6.47 | 3 | No | No | 8 | 8 | 1 | 2 | L:L:?1 | R:R:R111 | 8.9 | 3 | Yes | No | 0 | 8 | 0 | 1 | R:R:Q112 | R:R:T155 | 2.83 | 3 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:L158 | R:R:Q112 | 5.32 | 3 | No | Yes | 5 | 7 | 1 | 1 | R:R:M192 | R:R:Q112 | 2.72 | 3 | Yes | Yes | 5 | 7 | 1 | 1 | R:R:E196 | R:R:Q112 | 5.1 | 0 | No | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:Q112 | 8.86 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:L158 | R:R:M192 | 4.24 | 3 | No | Yes | 5 | 5 | 1 | 1 | L:L:?1 | R:R:L158 | 5.53 | 3 | Yes | No | 0 | 5 | 0 | 1 | R:R:H161 | R:R:L162 | 5.14 | 3 | Yes | No | 7 | 4 | 1 | 1 | R:R:H161 | R:R:W188 | 11.64 | 3 | Yes | No | 7 | 5 | 1 | 2 | R:R:H161 | R:R:H189 | 7.17 | 3 | Yes | No | 7 | 5 | 1 | 1 | L:L:?1 | R:R:H161 | 9.42 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:L162 | 9.21 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S178 | 8 | 3 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S179 | 10 | 3 | Yes | No | 0 | 4 | 0 | 1 | R:R:F180 | R:R:R251 | 5.34 | 3 | No | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 17.15 | 3 | No | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 13.78 | 3 | Yes | No | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 11.13 | 3 | No | No | 5 | 2 | 1 | 2 | R:R:M192 | R:R:W188 | 4.65 | 3 | Yes | No | 5 | 5 | 1 | 2 | L:L:?1 | R:R:H189 | 12.84 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:M192 | 6.59 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:F244 | R:R:T283 | 7.78 | 3 | Yes | No | 8 | 8 | 2 | 2 | R:R:F276 | R:R:R251 | 12.83 | 3 | Yes | Yes | 4 | 5 | 2 | 2 | R:R:F276 | R:R:L280 | 6.09 | 3 | Yes | No | 4 | 5 | 2 | 1 | R:R:L280 | R:R:T283 | 2.95 | 0 | No | No | 5 | 8 | 1 | 2 | L:L:?1 | R:R:L280 | 7.37 | 3 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y284 | 7.8 | 3 | Yes | No | 0 | 7 | 0 | 1 | R:R:R22 | R:R:W91 | 2 | 0 | Yes | Yes | 3 | 4 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 17.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 8.28 | Average Nodes In Shell | 37.00 | Average Hubs In Shell | 18.00 | Average Links In Shell | 55.00 | Average Links Mediated by Hubs In Shell | 52.00 |
| ![](/psngpcr/ligands/FI7/FI7_8J6R_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8J6R_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JZ7 | A | Alicarboxylic acid | Hydroxycarboxylic acid | HCA2 | Homo Sapiens | MK6892 | - | Gi1/Beta1/Gamma2 | 2.6 | 2023-10-04 | 10.1038/s41392-023-01625-y |
![](/psngpcr/ligands/FI7/FI7_8JZ7_L_L_1.png)
A 2D representation of the interactions of FI7 in 8JZ7 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:L34 | R:R:L80 | 2.77 | 2 | Yes | No | 8 | 8 | 2 | 2 | R:R:L34 | R:R:L83 | 2.77 | 2 | Yes | Yes | 8 | 6 | 2 | 1 | R:R:L34 | R:R:Y284 | 5.86 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:E37 | R:R:Y284 | 4.49 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:L107 | R:R:L76 | 2.77 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:C79 | R:R:M103 | 4.86 | 0 | No | Yes | 6 | 5 | 2 | 2 | R:R:C79 | R:R:L107 | 6.35 | 0 | No | No | 6 | 6 | 2 | 1 | R:R:L80 | R:R:Y284 | 2.34 | 2 | No | Yes | 8 | 7 | 2 | 1 | R:R:L83 | R:R:N86 | 2.75 | 2 | Yes | No | 6 | 5 | 1 | 2 | R:R:L83 | R:R:Y87 | 9.38 | 2 | Yes | Yes | 6 | 6 | 1 | 2 | R:R:L83 | R:R:M103 | 2.83 | 2 | Yes | Yes | 6 | 5 | 1 | 2 | R:R:L83 | R:R:Y284 | 3.52 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:L83 | 2.76 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F105 | R:R:M109 | 6.22 | 2 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:F105 | R:R:T159 | 6.49 | 2 | Yes | No | 6 | 7 | 2 | 1 | L:L:?1 | R:R:L107 | 10.14 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:A108 | 6.29 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:M109 | R:R:T155 | 4.52 | 2 | Yes | No | 5 | 7 | 2 | 2 | R:R:M109 | R:R:T159 | 7.53 | 2 | Yes | No | 5 | 7 | 2 | 1 | R:R:L280 | R:R:R111 | 2.43 | 2 | No | Yes | 5 | 8 | 1 | 1 | R:R:R111 | R:R:T283 | 7.76 | 2 | Yes | No | 8 | 8 | 1 | 2 | R:R:R111 | R:R:Y284 | 5.14 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:R111 | 7.28 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:Q112 | R:R:T155 | 2.83 | 0 | Yes | No | 7 | 7 | 1 | 2 | R:R:L158 | R:R:Q112 | 2.66 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:E196 | R:R:Q112 | 5.1 | 0 | No | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:Q112 | 7.09 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:T159 | 2.94 | 2 | Yes | No | 0 | 7 | 0 | 1 | R:R:H161 | R:R:L162 | 6.43 | 0 | No | No | 7 | 4 | 2 | 1 | R:R:H161 | R:R:W188 | 8.46 | 0 | No | No | 7 | 5 | 2 | 2 | L:L:?1 | R:R:L162 | 5.53 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:S178 | 5 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:H189 | R:R:S179 | 5.58 | 2 | Yes | No | 5 | 4 | 1 | 1 | L:L:?1 | R:R:S179 | 6 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:E190 | R:R:F180 | 7 | 2 | Yes | Yes | 4 | 3 | 2 | 1 | R:R:F180 | R:R:F193 | 3.22 | 2 | Yes | No | 3 | 6 | 1 | 2 | R:R:F180 | R:R:R251 | 5.34 | 2 | Yes | Yes | 3 | 5 | 1 | 2 | R:R:F180 | R:R:F276 | 4.29 | 2 | Yes | No | 3 | 4 | 1 | 2 | L:L:?1 | R:R:F180 | 19.46 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:H189 | R:R:Q187 | 9.89 | 2 | Yes | No | 5 | 2 | 1 | 2 | R:R:M192 | R:R:W188 | 4.65 | 0 | No | No | 5 | 5 | 1 | 2 | R:R:E190 | R:R:H189 | 2.46 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:H189 | 17.12 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:E190 | R:R:R251 | 11.63 | 2 | Yes | Yes | 4 | 5 | 2 | 2 | L:L:?1 | R:R:M192 | 5.65 | 2 | Yes | No | 0 | 5 | 0 | 1 | R:R:E196 | R:R:F193 | 5.83 | 0 | No | No | 5 | 6 | 2 | 2 | R:R:F276 | R:R:R251 | 21.38 | 2 | No | Yes | 4 | 5 | 2 | 2 | R:R:L280 | R:R:Y284 | 2.34 | 2 | No | Yes | 5 | 7 | 1 | 1 | L:L:?1 | R:R:L280 | 4.61 | 2 | Yes | No | 0 | 5 | 0 | 1 | L:L:?1 | R:R:Y284 | 6.24 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:S178 | R:R:S181 | 1.63 | 0 | No | No | 4 | 4 | 1 | 2 | |
Statistics | Value |
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Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 7.58 | Average Nodes In Shell | 37.00 | Average Hubs In Shell | 14.00 | Average Links In Shell | 51.00 | Average Links Mediated by Hubs In Shell | 44.00 |
| ![](/psngpcr/ligands/FI7/FI7_8JZ7_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/FI7/FI7_8JZ7_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
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