CodeFI7
Name2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
Synonyms
Identifier2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid
FormulaC19 H22 N4 O5
Molecular Weight386.402
SMILESCC(C)(Cc1nc(no1)c2ccc(cn2)O)C(=O)NC3=C(CCCC3)C(=O)O
PubChem135416394
Formal Charge0
Total Atoms50
Total Chiral Atoms0
Total Bonds52
Total Aromatic Bonds11
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK2 A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 3.1 2023-02-22 10.1038/s41467-023-37177-6

A 2D representation of the interactions of FI7 in 7XK2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E37 R:R:Y284 7.86 0 No Yes 7 7 2 1
R:R:L83 R:R:Y284 5.86 5 No Yes 6 7 1 1
L:L:?1 R:R:L83 3.69 5 Yes No 0 6 0 1
R:R:W91 R:R:Y87 16.4 5 Yes No 4 6 2 2
R:R:F277 R:R:Y87 4.13 5 Yes No 5 6 1 2
R:R:F277 R:R:W91 4.01 5 Yes Yes 5 4 1 2
L:L:?1 R:R:L104 4.61 5 Yes No 0 5 0 1
L:L:?1 R:R:L107 19.35 5 Yes No 0 6 0 1
L:L:?1 R:R:A108 5.24 5 Yes No 0 4 0 1
R:R:F193 R:R:R111 4.28 0 No Yes 6 8 2 1
R:R:F244 R:R:R111 4.28 5 Yes Yes 8 8 2 1
R:R:R111 R:R:T283 5.17 5 Yes No 8 8 1 2
L:L:?1 R:R:R111 4.85 5 Yes Yes 0 8 0 1
R:R:Q112 R:R:T155 4.25 0 No No 7 7 1 2
R:R:E196 R:R:Q112 16.57 0 No No 5 7 2 1
L:L:?1 R:R:Q112 6.2 5 Yes No 0 7 0 1
R:R:L158 R:R:M192 4.24 5 No No 5 5 1 1
L:L:?1 R:R:L158 3.69 5 Yes No 0 5 0 1
L:L:?1 R:R:L162 10.14 5 Yes No 0 4 0 1
L:L:?1 R:R:S179 6 5 Yes No 0 4 0 1
R:R:F180 R:R:R251 10.69 5 No No 3 5 1 2
R:R:F180 R:R:F276 8.57 5 No Yes 3 4 1 2
L:L:?1 R:R:F180 14.6 5 Yes No 0 3 0 1
R:R:M192 R:R:W188 9.31 5 No No 5 5 1 2
R:R:E190 R:R:H189 19.69 0 No No 4 5 2 1
L:L:?1 R:R:H189 16.26 5 Yes No 0 5 0 1
L:L:?1 R:R:M192 7.53 5 Yes No 0 5 0 1
R:R:E196 R:R:F193 5.83 0 No No 5 6 2 2
R:R:F244 R:R:T283 7.78 5 Yes No 8 8 2 2
R:R:F276 R:R:R251 11.76 5 Yes No 4 5 2 2
R:R:D273 R:R:F277 4.78 0 No Yes 4 5 2 1
R:R:F276 R:R:L280 8.53 5 Yes No 4 5 2 1
R:R:F277 R:R:L280 3.65 5 Yes No 5 5 1 1
L:L:?1 R:R:F277 4.05 5 Yes Yes 0 5 0 1
L:L:?1 R:R:L280 8.29 5 Yes No 0 5 0 1
R:R:S281 R:R:Y284 3.82 0 No Yes 6 7 2 1
R:R:T283 R:R:Y284 3.75 5 No Yes 8 7 2 1
L:L:?1 R:R:Y284 4.68 5 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.95
Average Nodes In Shell30.00
Average Hubs In Shell7.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IHF A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 2.97 2023-08-30 10.1038/s41467-023-41650-7

A 2D representation of the interactions of FI7 in 8IHF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E37 R:R:L34 3.98 1 No No 7 8 2 2
R:R:L34 R:R:Y284 5.86 1 No Yes 8 7 2 1
R:R:E37 R:R:Y284 6.73 1 No Yes 7 7 2 1
R:R:L80 R:R:Y284 4.69 0 No Yes 8 7 2 1
R:R:L83 R:R:Y87 5.86 1 Yes Yes 6 6 1 2
R:R:L83 R:R:M103 4.24 1 Yes No 6 5 1 2
R:R:L107 R:R:L83 6.92 1 No Yes 6 6 1 1
L:L:?1 R:R:L83 4.61 1 Yes Yes 0 6 0 1
R:R:N86 R:R:W91 10.17 0 No Yes 5 4 2 1
R:R:W91 R:R:Y87 8.68 1 Yes Yes 4 6 1 2
R:R:S178 R:R:W91 6.18 1 No Yes 4 4 1 1
R:R:F277 R:R:W91 10.02 1 Yes Yes 5 4 1 1
L:L:?1 R:R:W91 3.03 1 Yes Yes 0 4 0 1
R:R:C177 R:R:L104 4.76 30 No No 9 5 2 1
L:L:?1 R:R:L104 7.37 1 Yes No 0 5 0 1
R:R:F105 R:R:M109 8.71 1 No Yes 6 5 2 2
R:R:F105 R:R:T159 6.49 1 No Yes 6 7 2 1
L:L:?1 R:R:L107 10.14 1 Yes No 0 6 0 1
R:R:A108 R:R:T159 3.36 1 No Yes 4 7 1 1
L:L:?1 R:R:A108 7.34 1 Yes No 0 4 0 1
R:R:M109 R:R:T159 3.01 1 Yes Yes 5 7 2 1
R:R:E196 R:R:R111 3.49 1 No No 5 8 1 1
R:R:R111 R:R:T283 6.47 1 No No 8 8 1 2
L:L:?1 R:R:R111 9.71 1 Yes No 0 8 0 1
R:R:L158 R:R:Q112 5.32 1 Yes No 5 7 1 1
R:R:E196 R:R:Q112 15.29 1 No No 5 7 1 1
L:L:?1 R:R:Q112 8.86 1 Yes No 0 7 0 1
R:R:L158 R:R:M192 4.24 1 Yes No 5 5 1 1
L:L:?1 R:R:L158 3.69 1 Yes Yes 0 5 0 1
L:L:?1 R:R:T159 5.89 1 Yes Yes 0 7 0 1
R:R:H161 R:R:L162 5.14 1 Yes No 7 4 1 1
R:R:H161 R:R:W188 11.64 1 Yes No 7 5 1 2
R:R:H161 R:R:H189 3.58 1 Yes Yes 7 5 1 1
L:L:?1 R:R:H161 3.42 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L162 8.29 1 Yes No 0 4 0 1
L:L:?1 R:R:S178 4 1 Yes No 0 4 0 1
R:R:H189 R:R:S179 5.58 1 Yes No 5 4 1 1
L:L:?1 R:R:S179 10 1 Yes No 0 4 0 1
R:R:F180 R:R:F193 8.57 1 Yes No 3 6 1 2
R:R:F180 R:R:R251 4.28 1 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 8.57 1 Yes Yes 3 4 1 2
L:L:?1 R:R:F180 21.08 1 Yes Yes 0 3 0 1
R:R:H189 R:R:Q187 4.95 1 Yes No 5 2 1 2
L:L:?1 R:R:H189 16.26 1 Yes Yes 0 5 0 1
L:L:?1 R:R:M192 10.35 1 Yes No 0 5 0 1
R:R:F193 R:R:F276 4.29 1 No Yes 6 4 2 2
L:L:?1 R:R:E196 4.41 1 Yes No 0 5 0 1
R:R:F276 R:R:R251 14.97 1 Yes Yes 4 5 2 2
R:R:D273 R:R:F277 5.97 0 No Yes 4 5 2 1
R:R:F276 R:R:F277 4.29 1 Yes Yes 4 5 2 1
R:R:F276 R:R:L280 6.09 1 Yes No 4 5 2 1
L:L:?1 R:R:F277 4.05 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L280 6.45 1 Yes No 0 5 0 1
L:L:?1 R:R:Y284 7.02 1 Yes Yes 0 7 0 1
R:R:R22 R:R:W91 3 1 Yes Yes 3 4 2 1
R:R:I154 R:R:L158 1.43 0 No Yes 5 5 2 1
R:R:L195 R:R:M192 1.41 0 No No 4 5 2 1
StatisticsValue
Average Number Of Links20.00
Average Number Of Links With An Hub9.00
Average Interaction Strength7.80
Average Nodes In Shell40.00
Average Hubs In Shell15.00
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IJD A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 3.25 2024-01-03 10.1038/s41421-023-00610-7

A 2D representation of the interactions of FI7 in 8IJD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R22 R:R:W91 4 0 No Yes 3 4 2 1
R:R:E37 R:R:L34 9.28 2 Yes No 7 8 2 2
R:R:L34 R:R:Y284 7.03 2 No Yes 8 7 2 1
R:R:E37 R:R:Y284 4.49 2 Yes Yes 7 7 2 1
R:R:C79 R:R:L107 3.17 0 No No 6 6 2 1
R:R:L83 R:R:Y87 3.52 0 No Yes 6 6 2 2
R:R:L107 R:R:L83 2.77 0 No No 6 6 1 2
R:R:N86 R:R:W91 9.04 0 No Yes 5 4 2 1
R:R:W91 R:R:Y87 4.82 2 Yes Yes 4 6 1 2
R:R:F277 R:R:Y87 3.09 2 No Yes 5 6 2 2
R:R:L176 R:R:W91 3.42 2 Yes Yes 4 4 2 1
R:R:F277 R:R:W91 15.03 2 No Yes 5 4 2 1
L:L:?1 R:R:W91 3.79 2 Yes Yes 0 4 0 1
R:R:L104 R:R:M167 5.65 2 No Yes 5 3 1 2
R:R:C177 R:R:L104 3.17 2 Yes No 9 5 2 1
L:L:?1 R:R:L104 5.53 2 Yes No 0 5 0 1
R:R:F105 R:R:M109 3.73 2 Yes Yes 6 5 2 2
R:R:F105 R:R:T159 6.49 2 Yes Yes 6 7 2 1
L:L:?1 R:R:L107 9.21 2 Yes No 0 6 0 1
R:R:A108 R:R:T159 3.36 2 No Yes 4 7 1 1
L:L:?1 R:R:A108 8.39 2 Yes No 0 4 0 1
R:R:M109 R:R:T155 9.03 2 Yes No 5 7 2 2
R:R:M109 R:R:T159 6.02 2 Yes Yes 5 7 2 1
R:R:L280 R:R:R111 3.64 2 Yes Yes 5 8 1 1
R:R:R111 R:R:T283 11.64 2 Yes Yes 8 8 1 2
R:R:R111 R:R:Y284 4.12 2 Yes Yes 8 7 1 1
L:L:?1 R:R:R111 8.9 2 Yes Yes 0 8 0 1
R:R:Q112 R:R:T155 7.09 0 Yes No 7 7 1 2
R:R:L158 R:R:Q112 2.66 0 No Yes 5 7 2 1
R:R:E196 R:R:Q112 8.92 0 No Yes 5 7 2 1
L:L:?1 R:R:Q112 8.86 2 Yes Yes 0 7 0 1
R:R:L158 R:R:M192 2.83 0 No No 5 5 2 1
L:L:?1 R:R:T159 6.87 2 Yes Yes 0 7 0 1
R:R:H161 R:R:L162 10.29 0 No No 7 4 2 1
R:R:H161 R:R:H189 9.55 0 No Yes 7 5 2 1
L:L:?1 R:R:L162 6.45 2 Yes No 0 4 0 1
R:R:C177 R:R:M167 6.48 2 Yes Yes 9 3 2 2
L:L:?1 R:R:S179 13.99 2 Yes No 0 4 0 1
R:R:F180 R:R:F193 9.65 2 Yes Yes 3 6 1 2
R:R:F180 R:R:R251 7.48 2 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 11.79 2 Yes Yes 3 4 1 2
R:R:F180 R:R:L280 4.87 2 Yes Yes 3 5 1 1
L:L:?1 R:R:F180 16.22 2 Yes Yes 0 3 0 1
R:R:H189 R:R:Q187 12.36 2 Yes No 5 2 1 2
R:R:E190 R:R:Q187 10.19 2 Yes No 4 2 2 2
R:R:E190 R:R:H189 12.31 2 Yes Yes 4 5 2 1
L:L:?1 R:R:H189 5.14 2 Yes Yes 0 5 0 1
R:R:L195 R:R:M192 4.24 0 No No 4 5 2 1
L:L:?1 R:R:M192 4.71 2 Yes No 0 5 0 1
R:R:E196 R:R:F193 4.66 0 No Yes 5 6 2 2
R:R:F193 R:R:R251 5.34 2 Yes Yes 6 5 2 2
R:R:F276 R:R:R251 13.9 2 Yes Yes 4 5 2 2
R:R:F276 R:R:L280 13.4 2 Yes Yes 4 5 2 1
L:L:?1 R:R:L280 7.37 2 Yes Yes 0 5 0 1
R:R:T283 R:R:Y284 4.99 2 Yes Yes 8 7 2 1
L:L:?1 R:R:Y284 8.59 2 Yes Yes 0 7 0 1
R:R:G113 R:R:Q112 1.64 0 No Yes 7 7 2 1
R:R:R111 R:R:S114 1.32 2 Yes No 8 9 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength8.14
Average Nodes In Shell41.00
Average Hubs In Shell21.00
Average Links In Shell58.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IYH A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Go/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41467-024-46239-2

A 2D representation of the interactions of FI7 in 8IYH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L30 R:R:L34 12.46 3 Yes Yes 5 8 2 2
R:R:L30 R:R:Y87 7.03 3 Yes Yes 5 6 2 1
R:R:L30 R:R:S281 3 3 Yes No 5 6 2 2
R:R:L34 R:R:Y87 3.52 3 Yes Yes 8 6 2 1
R:R:L34 R:R:Y284 2.34 3 Yes Yes 8 7 2 1
R:R:E37 R:R:S281 4.31 3 Yes No 7 6 2 2
R:R:E37 R:R:Y284 4.49 3 Yes Yes 7 7 2 1
R:R:L107 R:R:L76 4.15 0 No No 6 7 1 2
R:R:L80 R:R:L83 4.15 3 No Yes 8 6 2 1
R:R:L80 R:R:Y284 2.34 3 No Yes 8 7 2 1
R:R:L83 R:R:N86 4.12 3 Yes No 6 5 1 2
R:R:L83 R:R:Y87 17.58 3 Yes Yes 6 6 1 1
R:R:L83 R:R:M103 4.24 3 Yes No 6 5 1 2
R:R:L83 R:R:Y284 3.52 3 Yes Yes 6 7 1 1
L:L:?1 R:R:L83 6.45 3 Yes Yes 0 6 0 1
R:R:N86 R:R:W91 9.04 0 No Yes 5 4 2 2
R:R:W91 R:R:Y87 4.82 0 Yes Yes 4 6 2 1
L:L:?1 R:R:Y87 2.34 3 Yes Yes 0 6 0 1
R:R:L104 R:R:M167 2.83 0 No Yes 5 3 1 2
L:L:?1 R:R:L104 1.84 3 Yes No 0 5 0 1
R:R:F105 R:R:T159 7.78 3 Yes No 6 7 2 1
L:L:?1 R:R:L107 7.37 3 Yes No 0 6 0 1
R:R:A108 R:R:T159 3.36 3 No No 4 7 1 1
L:L:?1 R:R:A108 7.34 3 Yes No 0 4 0 1
R:R:F180 R:R:R111 2.14 3 Yes Yes 3 8 1 1
R:R:F193 R:R:R111 3.21 3 Yes Yes 6 8 2 1
R:R:F244 R:R:R111 2.14 3 Yes Yes 8 8 2 1
R:R:L280 R:R:R111 3.64 3 Yes Yes 5 8 2 1
R:R:R111 R:R:T283 14.23 3 Yes Yes 8 8 1 2
L:L:?1 R:R:R111 8.9 3 Yes Yes 0 8 0 1
R:R:I116 R:R:Q112 5.49 0 No Yes 5 7 2 1
R:R:Q112 R:R:T155 9.92 3 Yes No 7 7 1 2
R:R:L158 R:R:Q112 13.31 3 No Yes 5 7 1 1
R:R:E196 R:R:Q112 14.02 3 No Yes 5 7 1 1
L:L:?1 R:R:Q112 7.09 3 Yes Yes 0 7 0 1
R:R:E196 R:R:I115 2.73 3 No Yes 5 8 1 2
R:R:F244 R:R:I115 8.79 3 Yes Yes 8 8 2 2
R:R:L158 R:R:M192 8.48 3 No No 5 5 1 1
L:L:?1 R:R:L158 5.53 3 Yes No 0 5 0 1
L:L:?1 R:R:T159 6.87 3 Yes No 0 7 0 1
R:R:H161 R:R:H189 5.97 0 No Yes 7 5 2 1
R:R:L162 R:R:S179 3 3 No No 4 4 1 1
R:R:H189 R:R:L162 10.29 3 Yes No 5 4 1 1
L:L:?1 R:R:L162 2.76 3 Yes No 0 4 0 1
R:R:K165 R:R:M167 2.88 0 No Yes 4 3 2 2
R:R:H189 R:R:K165 3.93 3 Yes No 5 4 1 2
R:R:H189 R:R:S179 4.18 3 Yes No 5 4 1 1
L:L:?1 R:R:S179 10 3 Yes No 0 4 0 1
R:R:F180 R:R:F193 6.43 3 Yes Yes 3 6 1 2
R:R:F180 R:R:R251 4.28 3 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 12.86 3 Yes Yes 3 4 1 2
R:R:F180 R:R:L280 3.65 3 Yes Yes 3 5 1 2
L:L:?1 R:R:F180 21.89 3 Yes Yes 0 3 0 1
R:R:H189 R:R:Q187 6.18 3 Yes No 5 2 1 2
R:R:E190 R:R:Q187 6.37 3 Yes No 4 2 2 2
R:R:E190 R:R:H189 3.69 3 Yes Yes 4 5 2 1
L:L:?1 R:R:H189 14.55 3 Yes Yes 0 5 0 1
R:R:E190 R:R:R251 5.82 3 Yes Yes 4 5 2 2
R:R:L195 R:R:M192 5.65 0 No No 4 5 2 1
L:L:?1 R:R:M192 6.59 3 Yes No 0 5 0 1
R:R:F193 R:R:R251 3.21 3 Yes Yes 6 5 2 2
R:R:F193 R:R:L280 2.44 3 Yes Yes 6 5 2 2
L:L:?1 R:R:E196 8.82 3 Yes No 0 5 0 1
R:R:F244 R:R:T283 5.19 3 Yes Yes 8 8 2 2
R:R:F276 R:R:R251 10.69 3 Yes Yes 4 5 2 2
R:R:F276 R:R:L280 7.31 3 Yes Yes 4 5 2 2
R:R:L280 R:R:T283 2.95 3 Yes Yes 5 8 2 2
R:R:S281 R:R:Y284 2.54 3 No Yes 6 7 2 1
R:R:T283 R:R:Y284 4.99 3 Yes Yes 8 7 2 1
L:L:?1 R:R:Y284 5.46 3 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.74
Average Nodes In Shell42.00
Average Hubs In Shell22.00
Average Links In Shell70.00
Average Links Mediated by Hubs In Shell65.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J6I A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 2.92 2024-04-03 10.1016/j.celrep.2023.113406

A 2D representation of the interactions of FI7 in 8J6I
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I26 R:R:L30 7.14 2 No No 5 5 2 2
R:R:I26 R:R:Y87 4.84 2 No Yes 5 6 2 1
R:R:L30 R:R:L34 2.77 2 No Yes 5 8 2 2
R:R:L30 R:R:Y87 7.03 2 No Yes 5 6 2 1
R:R:E37 R:R:L34 3.98 2 Yes Yes 7 8 2 2
R:R:L34 R:R:Y284 2.34 2 Yes Yes 8 7 2 1
R:R:E37 R:R:Y284 7.86 2 Yes Yes 7 7 2 1
R:R:C79 R:R:M103 3.24 2 Yes Yes 6 5 2 2
R:R:C79 R:R:L107 3.17 2 Yes No 6 6 2 1
R:R:L83 R:R:Y87 2.34 2 No Yes 6 6 1 1
R:R:L83 R:R:Y284 2.34 2 No Yes 6 7 1 1
L:L:?1 R:R:L83 11.06 2 Yes No 0 6 0 1
R:R:W91 R:R:Y87 1.93 2 Yes Yes 4 6 2 1
R:R:F277 R:R:Y87 2.06 2 Yes Yes 5 6 1 1
L:L:?1 R:R:Y87 3.12 2 Yes Yes 0 6 0 1
R:R:L104 R:R:M103 7.07 0 No Yes 5 5 1 2
L:L:?1 R:R:L104 9.21 2 Yes No 0 5 0 1
R:R:F105 R:R:M109 6.22 2 Yes Yes 6 5 2 2
R:R:F105 R:R:T159 10.38 2 Yes Yes 6 7 2 1
L:L:?1 R:R:L107 8.29 2 Yes No 0 6 0 1
L:L:?1 R:R:A108 6.29 2 Yes No 0 4 0 1
R:R:M109 R:R:T155 3.01 2 Yes No 5 7 2 2
R:R:M109 R:R:T159 4.52 2 Yes Yes 5 7 2 1
R:R:F180 R:R:R111 2.14 2 Yes No 3 8 1 1
R:R:F193 R:R:R111 4.28 0 No No 6 8 2 1
L:L:?1 R:R:R111 8.9 2 Yes No 0 8 0 1
R:R:I116 R:R:Q112 2.74 0 No Yes 5 7 2 1
R:R:Q112 R:R:T155 8.5 2 Yes No 7 7 1 2
R:R:E196 R:R:Q112 17.84 2 Yes Yes 5 7 1 1
L:L:?1 R:R:Q112 7.98 2 Yes Yes 0 7 0 1
R:R:I154 R:R:L158 5.71 0 No Yes 5 5 2 1
R:R:T155 R:R:T159 3.14 2 No Yes 7 7 2 1
R:R:L158 R:R:W188 2.28 2 Yes Yes 5 5 1 2
R:R:L158 R:R:M192 8.48 2 Yes Yes 5 5 1 1
L:L:?1 R:R:L158 3.69 2 Yes Yes 0 5 0 1
L:L:?1 R:R:T159 2.94 2 Yes Yes 0 7 0 1
R:R:H161 R:R:L162 9 2 Yes No 7 4 1 1
R:R:H161 R:R:W188 12.7 2 Yes Yes 7 5 1 2
R:R:H161 R:R:H189 2.39 2 Yes Yes 7 5 1 1
L:L:?1 R:R:H161 4.28 2 Yes Yes 0 7 0 1
L:L:?1 R:R:L162 7.37 2 Yes No 0 4 0 1
L:L:?1 R:R:S178 2 2 Yes No 0 4 0 1
L:L:?1 R:R:S179 4 2 Yes No 0 4 0 1
R:R:F180 R:R:H189 4.53 2 Yes Yes 3 5 1 1
R:R:F180 R:R:R251 2.14 2 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 7.5 2 Yes Yes 3 4 1 2
L:L:?1 R:R:F180 17.84 2 Yes Yes 0 3 0 1
R:R:H189 R:R:Q187 9.89 2 Yes Yes 5 2 1 2
R:R:E190 R:R:Q187 5.1 2 Yes Yes 4 2 2 2
R:R:H189 R:R:W188 2.12 2 Yes Yes 5 5 1 2
R:R:M192 R:R:W188 3.49 2 Yes Yes 5 5 1 2
R:R:E190 R:R:H189 12.31 2 Yes Yes 4 5 2 1
L:L:?1 R:R:H189 12.84 2 Yes Yes 0 5 0 1
R:R:E190 R:R:R251 9.3 2 Yes Yes 4 5 2 2
R:R:E196 R:R:M192 6.77 2 Yes Yes 5 5 1 1
L:L:?1 R:R:M192 6.59 2 Yes Yes 0 5 0 1
R:R:E196 R:R:F193 4.66 2 Yes No 5 6 1 2
R:R:F193 R:R:S247 2.64 0 No No 6 6 2 2
L:L:?1 R:R:E196 6.18 2 Yes Yes 0 5 0 1
R:R:F276 R:R:S247 3.96 2 Yes No 4 6 2 2
R:R:L280 R:R:S247 3 2 Yes No 5 6 1 2
R:R:F276 R:R:R251 14.97 2 Yes Yes 4 5 2 2
R:R:D273 R:R:F277 9.55 0 No Yes 4 5 2 1
R:R:F276 R:R:F277 4.29 2 Yes Yes 4 5 2 1
R:R:F276 R:R:L280 4.87 2 Yes Yes 4 5 2 1
L:L:?1 R:R:F277 4.05 2 Yes Yes 0 5 0 1
R:R:L280 R:R:Y284 2.34 2 Yes Yes 5 7 1 1
L:L:?1 R:R:L280 5.53 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y284 5.46 2 Yes Yes 0 7 0 1
R:R:E196 R:R:L195 1.33 2 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links20.00
Average Number Of Links With An Hub12.00
Average Interaction Strength6.88
Average Nodes In Shell42.00
Average Hubs In Shell25.00
Average Links In Shell70.00
Average Links Mediated by Hubs In Shell67.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8J6R A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 2.76 2023-12-06 10.1038/s41467-023-43537-z

A 2D representation of the interactions of FI7 in 8J6R
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I26 R:R:L30 7.14 3 Yes Yes 5 5 2 2
R:R:I26 R:R:Y87 3.63 3 Yes Yes 5 6 2 1
R:R:F277 R:R:I26 3.77 3 Yes Yes 5 5 2 2
R:R:L30 R:R:Y87 7.03 3 Yes Yes 5 6 2 1
R:R:P31 R:R:Y87 2.78 0 No Yes 6 6 2 1
R:R:E37 R:R:Y284 4.49 3 Yes No 7 7 2 1
R:R:L107 R:R:L76 2.77 3 Yes No 6 7 1 2
R:R:C79 R:R:L107 3.17 0 No Yes 6 6 2 1
R:R:L83 R:R:Y87 4.69 3 Yes Yes 6 6 2 1
R:R:L83 R:R:M103 2.83 3 Yes Yes 6 5 2 2
R:R:L107 R:R:L83 4.15 3 Yes Yes 6 6 1 2
R:R:L83 R:R:Y284 5.86 3 Yes No 6 7 2 1
R:R:N86 R:R:W91 6.78 3 No Yes 5 4 2 1
R:R:W91 R:R:Y87 4.82 3 Yes Yes 4 6 1 1
R:R:F277 R:R:Y87 3.09 3 Yes Yes 5 6 2 1
L:L:?1 R:R:Y87 4.68 3 Yes Yes 0 6 0 1
R:R:S178 R:R:W91 6.18 3 No Yes 4 4 1 1
R:R:F277 R:R:W91 16.04 3 Yes Yes 5 4 2 1
L:L:?1 R:R:W91 3.03 3 Yes Yes 0 4 0 1
R:R:L104 R:R:M103 2.83 0 No Yes 5 5 1 2
R:R:L107 R:R:M103 2.83 3 Yes Yes 6 5 1 2
L:L:?1 R:R:L104 10.14 3 Yes No 0 5 0 1
L:L:?1 R:R:L107 8.29 3 Yes Yes 0 6 0 1
L:L:?1 R:R:A108 6.29 3 Yes No 0 4 0 1
R:R:F244 R:R:R111 3.21 3 Yes No 8 8 2 1
R:R:R111 R:R:T283 6.47 3 No No 8 8 1 2
L:L:?1 R:R:R111 8.9 3 Yes No 0 8 0 1
R:R:Q112 R:R:T155 2.83 3 Yes Yes 7 7 1 2
R:R:L158 R:R:Q112 5.32 3 No Yes 5 7 1 1
R:R:M192 R:R:Q112 2.72 3 Yes Yes 5 7 1 1
R:R:E196 R:R:Q112 5.1 0 No Yes 5 7 2 1
L:L:?1 R:R:Q112 8.86 3 Yes Yes 0 7 0 1
R:R:L158 R:R:M192 4.24 3 No Yes 5 5 1 1
L:L:?1 R:R:L158 5.53 3 Yes No 0 5 0 1
R:R:H161 R:R:L162 5.14 3 Yes No 7 4 1 1
R:R:H161 R:R:W188 11.64 3 Yes No 7 5 1 2
R:R:H161 R:R:H189 7.17 3 Yes No 7 5 1 1
L:L:?1 R:R:H161 9.42 3 Yes Yes 0 7 0 1
L:L:?1 R:R:L162 9.21 3 Yes No 0 4 0 1
L:L:?1 R:R:S178 8 3 Yes No 0 4 0 1
L:L:?1 R:R:S179 10 3 Yes No 0 4 0 1
R:R:F180 R:R:R251 5.34 3 No Yes 3 5 1 2
R:R:F180 R:R:F276 17.15 3 No Yes 3 4 1 2
L:L:?1 R:R:F180 13.78 3 Yes No 0 3 0 1
R:R:H189 R:R:Q187 11.13 3 No No 5 2 1 2
R:R:M192 R:R:W188 4.65 3 Yes No 5 5 1 2
L:L:?1 R:R:H189 12.84 3 Yes No 0 5 0 1
L:L:?1 R:R:M192 6.59 3 Yes Yes 0 5 0 1
R:R:F244 R:R:T283 7.78 3 Yes No 8 8 2 2
R:R:F276 R:R:R251 12.83 3 Yes Yes 4 5 2 2
R:R:F276 R:R:L280 6.09 3 Yes No 4 5 2 1
R:R:L280 R:R:T283 2.95 0 No No 5 8 1 2
L:L:?1 R:R:L280 7.37 3 Yes No 0 5 0 1
L:L:?1 R:R:Y284 7.8 3 Yes No 0 7 0 1
R:R:R22 R:R:W91 2 0 Yes Yes 3 4 2 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.28
Average Nodes In Shell37.00
Average Hubs In Shell18.00
Average Links In Shell55.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JZ7 A Alicarboxylic acid Hydroxycarboxylic acid HCA2 Homo Sapiens MK6892 - Gi1/Beta1/Gamma2 2.6 2023-10-04 10.1038/s41392-023-01625-y

A 2D representation of the interactions of FI7 in 8JZ7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L34 R:R:L80 2.77 2 Yes No 8 8 2 2
R:R:L34 R:R:L83 2.77 2 Yes Yes 8 6 2 1
R:R:L34 R:R:Y284 5.86 2 Yes Yes 8 7 2 1
R:R:E37 R:R:Y284 4.49 0 No Yes 7 7 2 1
R:R:L107 R:R:L76 2.77 0 No No 6 7 1 2
R:R:C79 R:R:M103 4.86 0 No Yes 6 5 2 2
R:R:C79 R:R:L107 6.35 0 No No 6 6 2 1
R:R:L80 R:R:Y284 2.34 2 No Yes 8 7 2 1
R:R:L83 R:R:N86 2.75 2 Yes No 6 5 1 2
R:R:L83 R:R:Y87 9.38 2 Yes Yes 6 6 1 2
R:R:L83 R:R:M103 2.83 2 Yes Yes 6 5 1 2
R:R:L83 R:R:Y284 3.52 2 Yes Yes 6 7 1 1
L:L:?1 R:R:L83 2.76 2 Yes Yes 0 6 0 1
R:R:F105 R:R:M109 6.22 2 Yes Yes 6 5 2 2
R:R:F105 R:R:T159 6.49 2 Yes No 6 7 2 1
L:L:?1 R:R:L107 10.14 2 Yes No 0 6 0 1
L:L:?1 R:R:A108 6.29 2 Yes No 0 4 0 1
R:R:M109 R:R:T155 4.52 2 Yes No 5 7 2 2
R:R:M109 R:R:T159 7.53 2 Yes No 5 7 2 1
R:R:L280 R:R:R111 2.43 2 No Yes 5 8 1 1
R:R:R111 R:R:T283 7.76 2 Yes No 8 8 1 2
R:R:R111 R:R:Y284 5.14 2 Yes Yes 8 7 1 1
L:L:?1 R:R:R111 7.28 2 Yes Yes 0 8 0 1
R:R:Q112 R:R:T155 2.83 0 Yes No 7 7 1 2
R:R:L158 R:R:Q112 2.66 0 No Yes 5 7 2 1
R:R:E196 R:R:Q112 5.1 0 No Yes 5 7 2 1
L:L:?1 R:R:Q112 7.09 2 Yes Yes 0 7 0 1
L:L:?1 R:R:T159 2.94 2 Yes No 0 7 0 1
R:R:H161 R:R:L162 6.43 0 No No 7 4 2 1
R:R:H161 R:R:W188 8.46 0 No No 7 5 2 2
L:L:?1 R:R:L162 5.53 2 Yes No 0 4 0 1
L:L:?1 R:R:S178 5 2 Yes No 0 4 0 1
R:R:H189 R:R:S179 5.58 2 Yes No 5 4 1 1
L:L:?1 R:R:S179 6 2 Yes No 0 4 0 1
R:R:E190 R:R:F180 7 2 Yes Yes 4 3 2 1
R:R:F180 R:R:F193 3.22 2 Yes No 3 6 1 2
R:R:F180 R:R:R251 5.34 2 Yes Yes 3 5 1 2
R:R:F180 R:R:F276 4.29 2 Yes No 3 4 1 2
L:L:?1 R:R:F180 19.46 2 Yes Yes 0 3 0 1
R:R:H189 R:R:Q187 9.89 2 Yes No 5 2 1 2
R:R:M192 R:R:W188 4.65 0 No No 5 5 1 2
R:R:E190 R:R:H189 2.46 2 Yes Yes 4 5 2 1
L:L:?1 R:R:H189 17.12 2 Yes Yes 0 5 0 1
R:R:E190 R:R:R251 11.63 2 Yes Yes 4 5 2 2
L:L:?1 R:R:M192 5.65 2 Yes No 0 5 0 1
R:R:E196 R:R:F193 5.83 0 No No 5 6 2 2
R:R:F276 R:R:R251 21.38 2 No Yes 4 5 2 2
R:R:L280 R:R:Y284 2.34 2 No Yes 5 7 1 1
L:L:?1 R:R:L280 4.61 2 Yes No 0 5 0 1
L:L:?1 R:R:Y284 6.24 2 Yes Yes 0 7 0 1
R:R:S178 R:R:S181 1.63 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.58
Average Nodes In Shell37.00
Average Hubs In Shell14.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links16.57
Average Number Of Links With An Hub7.29
Average Interaction Strength7.77
Average Nodes In Shell38.43
Average Hubs In Shell17.43
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell51.86

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)