CodeFME
NameN-Formylmethionine
Synonyms
  • L-N-Formylmethionine
  • N-formyl-L-methionine
  • (2S)-2-(formylamino)-4-(methylthio)butanoic acid
  • N-Formylmethionine
  • Formyl-methionine
Identifier(2S)-2-formamido-4-methylsulfanyl-butanoic acid
FormulaC6 H11 N O3 S
Molecular Weight177.221
SMILESCSCC[C@@H](C(=O)O)NC=O
PubChem439750
Formal Charge0
Total Atoms22
Total Chiral Atoms1
Total Bonds21
Total Aromatic Bonds0
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EUO A Peptide Formylpeptide FPR1-ALX Homo sapiens fMLF - Gi1/Beta1/Gamma2 2.9 2022-05-25 10.1038/s41467-022-32822-y

A 2D representation of the interactions of FME in 7EUO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F74 R:R:V105 7.87 3 Yes Yes 7 6 2 2
R:R:F74 R:R:L109 12.18 3 Yes Yes 7 8 2 1
R:R:L109 R:R:V105 2.98 3 Yes Yes 8 6 1 2
L:L:L2 R:R:V105 2.98 0 No Yes 0 6 1 2
R:R:D106 R:R:F110 7.17 3 Yes Yes 5 7 1 1
R:R:D106 R:R:T157 8.67 3 Yes No 5 7 1 2
R:R:D106 R:R:V160 5.84 3 Yes Yes 5 4 1 2
R:R:D106 R:R:R201 3.57 3 Yes Yes 5 5 1 1
L:L:?1 R:R:D106 13.68 3 Yes Yes 0 5 0 1
R:R:L109 R:R:W254 3.42 3 Yes Yes 8 9 1 1
L:L:?1 R:R:L109 5.07 3 Yes Yes 0 8 0 1
R:R:F110 R:R:F114 6.43 3 Yes No 7 6 1 2
R:R:F110 R:R:L156 6.09 3 Yes No 7 5 1 2
L:L:?1 R:R:F110 18.98 3 Yes Yes 0 7 0 1
R:R:V113 R:R:W254 3.68 0 No Yes 8 9 2 1
R:R:T157 R:R:V160 3.17 3 No Yes 7 4 2 2
R:R:F178 R:R:R201 10.69 0 Yes Yes 4 5 2 1
R:R:L198 R:R:R201 3.64 0 No Yes 4 5 2 1
L:L:F3 R:R:L198 4.87 0 Yes No 0 4 2 2
L:L:?1 R:R:R201 12.25 3 Yes Yes 0 5 0 1
R:R:R205 R:R:Y257 4.12 3 Yes Yes 6 7 1 1
R:R:Q258 R:R:R205 7.01 3 Yes Yes 8 6 2 1
R:R:A261 R:R:R205 4.15 0 No Yes 6 6 2 1
L:L:?1 R:R:R205 11.13 3 Yes Yes 0 6 0 1
L:L:F3 R:R:R205 6.41 0 Yes Yes 0 6 2 1
R:R:F250 R:R:W254 3.01 0 No Yes 9 9 2 1
R:R:W254 R:R:Y257 2.89 3 Yes Yes 9 7 1 1
R:R:Q258 R:R:W254 3.29 3 Yes Yes 8 9 2 1
R:R:A290 R:R:W254 5.19 3 No Yes 8 9 2 1
R:R:N293 R:R:W254 9.04 0 No Yes 9 9 2 1
L:L:?1 R:R:W254 3.13 3 Yes Yes 0 9 0 1
R:R:T286 R:R:Y257 7.49 0 No Yes 7 7 2 1
R:R:A290 R:R:Y257 2.67 3 No Yes 8 7 2 1
L:L:?1 R:R:Y257 4.3 3 Yes Yes 0 7 0 1
L:L:?1 L:L:L2 3.81 3 Yes No 0 0 0 1
L:L:?1 R:R:G209 1.57 3 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.21
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T6T A Peptide Formylpeptide FPR1-ALX Homo sapiens fMLFII - Gi1/Beta1/Gamma2 3.2 2022-03-30 10.1038/s41467-022-28586-0

A 2D representation of the interactions of FME in 7T6T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D106 17.41 2 Yes Yes 0 5 0 1
L:L:?1 R:R:L109 5.07 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F110 22.33 2 Yes Yes 0 7 0 1
L:L:?1 R:R:V113 4.1 2 Yes Yes 0 8 0 1
L:L:?1 R:R:R201 13.36 2 Yes Yes 0 5 0 1
L:L:?1 R:R:R205 24.5 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W254 4.18 2 Yes Yes 0 9 0 1
L:L:?1 R:R:Y257 6.45 2 Yes Yes 0 7 0 1
L:L:L2 R:R:V105 4.47 2 Yes Yes 0 6 2 2
L:L:L2 R:R:D106 4.07 2 Yes Yes 0 5 2 1
L:L:L2 R:R:F291 3.65 2 Yes Yes 0 7 2 2
L:L:F3 R:R:R205 8.55 2 Yes Yes 0 6 2 1
L:L:F3 R:R:Y257 5.16 2 Yes Yes 0 7 2 1
L:L:F3 R:R:A261 2.77 2 Yes No 0 6 2 2
R:R:F74 R:R:V105 3.93 2 Yes Yes 7 6 2 2
R:R:F74 R:R:L109 12.18 2 Yes Yes 7 8 2 1
R:R:F291 R:R:F74 16.08 2 Yes Yes 7 7 2 2
R:R:L109 R:R:V105 2.98 2 Yes Yes 8 6 1 2
R:R:D106 R:R:T157 4.34 2 Yes Yes 5 7 1 2
R:R:D106 R:R:V160 4.38 2 Yes Yes 5 4 1 2
R:R:D106 R:R:R201 4.76 2 Yes Yes 5 5 1 1
R:R:L109 R:R:W254 5.69 2 Yes Yes 8 9 1 1
R:R:F291 R:R:L109 7.31 2 Yes Yes 7 8 2 1
R:R:F110 R:R:F114 7.5 0 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 7.31 0 Yes No 7 5 1 2
R:R:F110 R:R:G209 3.01 0 Yes No 7 6 1 2
R:R:P213 R:R:V113 3.53 0 Yes Yes 9 8 2 1
R:R:F250 R:R:V113 3.93 2 Yes Yes 9 8 2 1
R:R:V113 R:R:W254 6.13 2 Yes Yes 8 9 1 1
R:R:F114 R:R:P213 2.89 0 Yes Yes 6 9 2 2
R:R:T157 R:R:V160 3.17 2 Yes Yes 7 4 2 2
R:R:F178 R:R:P159 2.89 2 Yes No 4 8 2 2
R:R:P159 R:R:R201 2.88 2 No Yes 8 5 2 1
R:R:R201 R:R:V160 3.92 2 Yes Yes 5 4 1 2
R:R:F178 R:R:R201 9.62 2 Yes Yes 4 5 2 1
R:R:R201 R:R:R205 3.2 2 Yes Yes 5 6 1 1
R:R:G202 R:R:R205 4.5 0 No Yes 5 6 2 1
R:R:R205 R:R:Y257 8.23 2 Yes Yes 6 7 1 1
R:R:Q258 R:R:R205 9.35 2 Yes Yes 8 6 2 1
R:R:A261 R:R:R205 5.53 2 No Yes 6 6 2 1
R:R:G209 R:R:P213 4.06 0 No Yes 6 9 2 2
R:R:F250 R:R:W254 6.01 2 Yes Yes 9 9 2 1
R:R:F250 R:R:N293 4.83 2 Yes Yes 9 9 2 2
R:R:W254 R:R:Y257 2.89 2 Yes Yes 9 7 1 1
R:R:Q258 R:R:W254 3.29 2 Yes Yes 8 9 2 1
R:R:A290 R:R:W254 7.78 2 No Yes 8 9 2 1
R:R:N293 R:R:W254 9.04 2 Yes Yes 9 9 2 1
R:R:Q258 R:R:Y257 3.38 2 Yes Yes 8 7 2 1
R:R:A261 R:R:Y257 2.67 2 No Yes 6 7 2 1
R:R:T286 R:R:Y257 3.75 0 No Yes 7 7 2 1
R:R:S287 R:R:Y257 3.82 0 No Yes 6 7 2 1
R:R:A290 R:R:Y257 4 2 No Yes 8 7 2 1
R:R:F291 R:R:S287 5.28 2 Yes No 7 6 2 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub8.00
Average Interaction Strength12.18
Average Nodes In Shell30.00
Average Hubs In Shell22.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell53.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7T6V A Peptide Formylpeptide FPR2-ALX Homo sapiens fMLFII - Gi1/Beta1/Gamma2 3.1 2022-03-30 10.1038/s41467-022-28586-0

A 2D representation of the interactions of FME in 7T6V
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F74 R:R:V105 7.87 0 Yes Yes 7 6 2 2
R:R:F74 R:R:L109 10.96 0 Yes No 7 8 2 1
R:R:D106 R:R:V105 4.38 6 Yes Yes 5 6 1 2
L:L:L2 R:R:V105 4.47 6 No Yes 0 6 2 2
R:R:D106 R:R:R201 4.76 6 Yes Yes 5 5 1 1
L:L:?1 R:R:D106 18.66 6 Yes Yes 0 5 0 1
L:L:L2 R:R:D106 5.43 6 No Yes 0 5 2 1
L:L:?1 R:R:L109 6.34 6 Yes No 0 8 0 1
R:R:F110 R:R:F114 6.43 0 No Yes 7 6 1 2
L:L:?1 R:R:F110 23.44 6 Yes No 0 7 0 1
R:R:F178 R:R:R201 9.62 6 Yes Yes 4 5 2 1
R:R:R201 R:R:R205 8.53 6 Yes Yes 5 5 1 1
L:L:?1 R:R:R201 12.25 6 Yes Yes 0 5 0 1
R:R:G202 R:R:R205 6 0 No Yes 4 5 2 1
R:R:Q258 R:R:R205 5.84 0 No Yes 8 5 2 1
L:L:?1 R:R:R205 16.7 6 Yes Yes 0 5 0 1
L:L:F3 R:R:R205 4.28 0 No Yes 0 5 2 1
R:R:F257 R:R:T287 5.19 0 No No 7 7 1 2
L:L:?1 R:R:F257 5.58 6 Yes No 0 7 0 1
R:R:A261 R:R:R205 2.77 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength13.83
Average Nodes In Shell17.00
Average Hubs In Shell8.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VFX A Peptide Formylpeptide FPR1-ALX Homo sapiens fMLF - Gi1/Beta1/Gamma2 2.8 2022-09-21 10.1038/s41467-022-32822-y

A 2D representation of the interactions of FME in 7VFX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F74 R:R:L109 8.53 0 Yes No 7 8 2 1
R:R:D106 R:R:F110 7.17 5 No Yes 5 7 1 1
R:R:D106 R:R:T157 8.67 5 No Yes 5 7 1 2
L:L:?1 R:R:D106 12.44 5 Yes No 0 5 0 1
L:L:?1 R:R:L109 5.07 5 Yes No 0 8 0 1
R:R:F110 R:R:F114 4.29 5 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 10.96 5 Yes No 7 5 1 2
L:L:?1 R:R:F110 12.28 5 Yes Yes 0 7 0 1
R:R:F178 R:R:R201 10.69 5 Yes Yes 4 5 2 1
R:R:R201 R:R:R205 7.46 5 Yes Yes 5 6 1 1
L:L:?1 R:R:R201 12.25 5 Yes Yes 0 5 0 1
R:R:G202 R:R:R205 3 0 No Yes 5 6 2 1
L:L:?1 R:R:R205 17.82 5 Yes Yes 0 6 0 1
L:L:F3 R:R:R205 5.34 0 No Yes 0 6 2 1
R:R:T286 R:R:Y257 7.49 0 No Yes 7 7 2 1
R:R:S287 R:R:Y257 6.36 0 No Yes 6 7 2 1
R:R:A290 R:R:Y257 4 0 No Yes 8 7 2 1
L:L:?1 R:R:Y257 4.3 5 Yes Yes 0 7 0 1
L:L:?1 L:L:I2 3.92 5 Yes No 0 0 0 1
R:R:P159 R:R:R201 1.44 0 No Yes 8 5 2 1
R:R:A261 R:R:R205 1.38 0 No Yes 6 6 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.73
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WVU A Peptide Formylpeptide FPR1-ALX Homo sapiens fMLF - Gi1/Beta1/Gamma2 3.3 2022-04-13 10.1038/s41467-022-29361-x

A 2D representation of the interactions of FME in 7WVU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L2 R:R:F102 6.09 0 No Yes 0 6 1 2
R:R:L109 R:R:V105 2.98 0 No Yes 8 6 1 2
R:R:D106 R:R:F110 9.55 2 No Yes 5 7 1 1
R:R:D106 R:R:T157 13.01 2 No Yes 5 7 1 2
L:L:?1 R:R:D106 8.71 2 Yes No 0 5 0 1
R:R:F291 R:R:L109 6.09 0 Yes No 7 8 2 1
L:L:?1 R:R:L109 10.15 2 Yes No 0 8 0 1
R:R:A153 R:R:F110 2.77 0 No Yes 8 7 2 1
R:R:F110 R:R:L156 6.09 2 Yes No 7 5 1 2
L:L:?1 R:R:F110 17.86 2 Yes Yes 0 7 0 1
R:R:V113 R:R:W254 6.13 0 No Yes 8 9 2 1
R:R:T157 R:R:V160 4.76 0 Yes Yes 7 4 2 2
R:R:F178 R:R:V160 5.24 2 Yes Yes 4 4 2 2
R:R:R201 R:R:V160 3.92 2 Yes Yes 5 4 1 2
R:R:F178 R:R:R201 10.69 2 Yes Yes 4 5 2 1
R:R:R201 R:R:R205 3.2 2 Yes Yes 5 6 1 1
L:L:?1 R:R:R201 8.91 2 Yes Yes 0 5 0 1
R:R:G202 R:R:R205 6 0 No Yes 5 6 2 1
R:R:A261 R:R:R205 2.77 0 No Yes 6 6 2 1
L:L:?1 R:R:R205 16.7 2 Yes Yes 0 6 0 1
L:L:F3 R:R:R205 5.34 0 No Yes 0 6 2 1
R:R:F250 R:R:W254 9.02 0 No Yes 9 9 2 1
R:R:W254 R:R:Y257 2.89 2 Yes Yes 9 7 1 1
R:R:Q258 R:R:W254 3.29 2 Yes Yes 8 9 2 1
R:R:A290 R:R:W254 7.78 2 No Yes 8 9 2 1
R:R:N293 R:R:W254 9.04 0 Yes Yes 9 9 2 1
L:L:?1 R:R:W254 6.26 2 Yes Yes 0 9 0 1
R:R:Q258 R:R:Y257 3.38 2 Yes Yes 8 7 2 1
R:R:T286 R:R:Y257 7.49 0 No Yes 7 7 2 1
R:R:A290 R:R:Y257 4 2 No Yes 8 7 2 1
L:L:?1 R:R:Y257 9.67 2 Yes Yes 0 7 0 1
L:L:?1 L:L:L2 6.34 2 Yes No 0 0 0 1
R:R:F110 R:R:G111 1.51 2 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.58
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WVV A Peptide Formylpeptide FPR2-ALX Homo sapiens fMLFII - Gi2/Beta1/Gamma2 2.9 2022-04-13 10.1038/s41467-022-29361-x

A 2D representation of the interactions of FME in 7WVV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:L2 3.81 4 Yes No 0 0 0 1
L:L:?1 R:R:D106 14.93 4 Yes Yes 0 5 0 1
L:L:?1 R:R:L109 8.88 4 Yes No 0 8 0 1
L:L:?1 R:R:F110 16.75 4 Yes Yes 0 7 0 1
L:L:?1 R:R:R201 11.13 4 Yes Yes 0 5 0 1
L:L:?1 R:R:R205 22.27 4 Yes Yes 0 5 0 1
L:L:?1 R:R:W254 6.26 4 Yes Yes 0 9 0 1
L:L:?1 R:R:F257 6.7 4 Yes Yes 0 7 0 1
L:L:I4 L:L:L2 4.28 0 Yes No 0 0 2 1
L:L:L2 R:R:V105 5.96 0 No Yes 0 6 1 2
L:L:F3 R:R:R205 3.21 4 Yes Yes 0 5 2 1
L:L:F3 R:R:A261 2.77 4 Yes No 0 5 2 2
L:L:I4 R:R:F178 5.02 0 Yes No 0 4 2 2
R:R:F74 R:R:V105 5.24 4 Yes Yes 7 6 2 2
R:R:F74 R:R:L109 8.53 4 Yes No 7 8 2 1
R:R:L109 R:R:V105 2.98 4 No Yes 8 6 1 2
R:R:D106 R:R:F110 8.36 4 Yes Yes 5 7 1 1
R:R:D106 R:R:T157 10.12 4 Yes Yes 5 7 1 2
R:R:D106 R:R:V160 5.84 4 Yes No 5 4 1 2
R:R:D106 R:R:R201 3.57 4 Yes Yes 5 5 1 1
R:R:F110 R:R:F114 3.22 4 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 10.96 4 Yes No 7 5 1 2
R:R:V113 R:R:W254 4.9 0 No Yes 7 9 2 1
R:R:T157 R:R:V160 3.17 4 Yes No 7 4 2 2
R:R:R201 R:R:V160 3.92 4 Yes No 5 4 1 2
R:R:F178 R:R:R201 8.55 0 No Yes 4 5 2 1
R:R:R201 R:R:R205 4.26 4 Yes Yes 5 5 1 1
R:R:G202 R:R:R205 4.5 0 No Yes 4 5 2 1
R:R:Q258 R:R:R205 8.18 4 Yes Yes 8 5 2 1
R:R:A261 R:R:R205 5.53 4 No Yes 5 5 2 1
R:R:F250 R:R:W254 10.02 0 No Yes 9 9 2 1
R:R:F257 R:R:W254 3.01 4 Yes Yes 7 9 1 1
R:R:Q258 R:R:W254 3.29 4 Yes Yes 8 9 2 1
R:R:A291 R:R:W254 7.78 4 No Yes 8 9 2 1
R:R:N294 R:R:W254 6.78 0 No Yes 9 9 2 1
R:R:F257 R:R:T287 9.08 4 Yes No 7 7 1 2
R:R:A291 R:R:F257 5.55 4 No Yes 8 7 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.34
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WVW A Peptide Formylpeptide FPR2-ALX Homo sapiens fMYFINILTL - Gi2/Beta1/Gamma2 3.1 2022-04-13 10.1038/s41467-022-29361-x

A 2D representation of the interactions of FME in 7WVW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D106 7.46 3 Yes No 0 5 0 1
L:L:?1 R:R:L109 6.34 3 Yes No 0 8 0 1
L:L:?1 R:R:F110 16.75 3 Yes Yes 0 7 0 1
L:L:?1 R:R:R201 13.36 3 Yes Yes 0 5 0 1
L:L:?1 R:R:R205 24.5 3 Yes Yes 0 5 0 1
L:L:?1 R:R:W254 5.22 3 Yes Yes 0 9 0 1
L:L:?1 R:R:F257 6.7 3 Yes Yes 0 7 0 1
L:L:?1 R:R:Q258 3.66 3 Yes Yes 0 8 0 1
R:R:F74 R:R:L109 9.74 0 Yes No 7 8 2 1
R:R:D106 R:R:F110 8.36 3 No Yes 5 7 1 1
R:R:D106 R:R:T157 11.56 3 No Yes 5 7 1 2
R:R:F110 R:R:F114 7.5 3 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 4.87 3 Yes No 7 5 1 2
R:R:V113 R:R:W254 3.68 0 No Yes 7 9 2 1
R:R:T157 R:R:V160 4.76 3 Yes No 7 4 2 2
R:R:R201 R:R:V160 3.92 3 Yes No 5 4 1 2
R:R:F178 R:R:R201 4.28 0 Yes Yes 4 5 2 1
R:R:R201 R:R:R205 3.2 3 Yes Yes 5 5 1 1
R:R:Q258 R:R:R205 7.01 3 Yes Yes 8 5 1 1
R:R:A261 R:R:R205 5.53 0 No Yes 5 5 2 1
R:R:F210 R:R:Q258 17.57 0 Yes Yes 9 8 2 1
R:R:F250 R:R:W254 14.03 3 No Yes 9 9 2 1
R:R:F250 R:R:N294 4.83 3 No Yes 9 9 2 2
R:R:C253 R:R:W254 5.22 3 No Yes 8 9 2 1
R:R:C253 R:R:N294 11.02 3 No Yes 8 9 2 2
R:R:Q258 R:R:W254 5.48 3 Yes Yes 8 9 1 1
R:R:A291 R:R:W254 5.19 0 No Yes 8 9 2 1
R:R:N294 R:R:W254 7.91 3 Yes Yes 9 9 2 1
R:R:F257 R:R:T287 9.08 0 Yes No 7 7 1 2
R:R:F257 R:R:S288 5.28 0 Yes No 7 6 1 2
L:L:F3 R:R:F257 2.14 0 No Yes 0 7 2 1
R:R:F110 R:R:G111 1.51 3 Yes No 7 7 1 2
R:R:F114 R:R:G111 1.51 3 Yes No 6 7 2 2
R:R:A153 R:R:F110 1.39 3 No Yes 8 7 2 1
R:R:A153 R:R:F114 1.39 3 No Yes 8 6 2 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.50
Average Nodes In Shell27.00
Average Hubs In Shell13.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WVX A Peptide Formylpeptide FPR2-ALX Homo sapiens Humanin - Gi2/Beta1/Gamma2 2.8 2022-04-13 10.1038/s41467-022-29361-x

A 2D representation of the interactions of FME in 7WVX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D106 9.95 4 Yes Yes 0 5 0 1
L:L:?1 R:R:L109 6.34 4 Yes No 0 8 0 1
L:L:?1 R:R:F110 20.09 4 Yes Yes 0 7 0 1
L:L:?1 R:R:R201 14.48 4 Yes No 0 5 0 1
L:L:?1 R:R:R205 25.61 4 Yes Yes 0 5 0 1
L:L:?1 R:R:W254 6.26 4 Yes Yes 0 9 0 1
L:L:?1 R:R:F257 4.47 4 Yes Yes 0 7 0 1
L:L:?1 R:R:Q258 3.66 4 Yes Yes 0 8 0 1
L:L:P3 R:R:F257 8.67 0 No Yes 0 7 2 1
R:R:D106 R:R:F110 8.36 4 Yes Yes 5 7 1 1
R:R:D106 R:R:T157 11.56 4 Yes Yes 5 7 1 2
R:R:D106 R:R:V160 5.84 4 Yes No 5 4 1 2
R:R:F110 R:R:F114 8.57 4 Yes Yes 7 6 1 2
R:R:F110 R:R:L156 9.74 4 Yes No 7 5 1 2
R:R:T157 R:R:V160 4.76 4 Yes No 7 4 2 2
R:R:F178 R:R:R201 8.55 0 No No 4 5 2 1
R:R:R201 R:R:R205 5.33 4 No Yes 5 5 1 1
R:R:Q258 R:R:R205 8.18 4 Yes Yes 8 5 1 1
R:R:A261 R:R:R205 5.53 0 No Yes 5 5 2 1
R:R:F210 R:R:Q258 18.74 0 Yes Yes 9 8 2 1
R:R:F250 R:R:W254 11.02 0 No Yes 9 9 2 1
R:R:Q258 R:R:W254 5.48 4 Yes Yes 8 9 1 1
R:R:A291 R:R:W254 7.78 0 No Yes 8 9 2 1
R:R:N294 R:R:W254 7.91 0 Yes Yes 9 9 2 1
R:R:F257 R:R:T287 7.78 0 Yes No 7 7 1 2
R:R:A291 R:R:F257 4.16 0 No Yes 8 7 2 1
L:L:?1 L:L:A2 2.89 4 Yes No 0 0 0 1
R:R:F110 R:R:G111 1.51 4 Yes No 7 7 1 2
R:R:F114 R:R:G111 1.51 4 Yes No 6 7 2 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.42
Average Nodes In Shell23.00
Average Hubs In Shell11.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.88
Average Number Of Links With An Hub5.62
Average Interaction Strength10.85
Average Nodes In Shell24.50
Average Hubs In Shell13.12
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell32.75

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)