CodeFSY
NameFevipiprant
Synonyms(2-methyl-1-{[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid
Identifier2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]ethanoic acid
FormulaC19 H17 F3 N2 O4 S
Molecular Weight426.409
SMILESCc1c(c2cccnc2n1Cc3ccc(cc3C(F)(F)F)S(=O)(=O)C)CC(=O)O
PubChem23582412
Formal Charge0
Total Atoms46
Total Chiral Atoms0
Total Bonds48
Total Aromatic Bonds16
Networks1
 missing image

This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6D26 A Lipid Prostanoid DP2 Homo sapiens Fevipiprant - - 2.8 2018-10-03 10.1016/j.molcel.2018.08.009

A 2D representation of the interactions of FSY in 6D26
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M17 R:R:M181 4.33 0 No Yes 7 4 2 1
R:R:M17 R:R:W283 9.31 0 No Yes 7 4 2 1
R:R:F87 R:R:H39 7.92 1 No Yes 6 8 1 2
R:R:H39 R:R:L91 3.86 1 Yes Yes 8 5 2 2
R:R:F87 R:R:L91 8.53 1 No Yes 6 5 1 2
L:L:?1 R:R:F87 5.56 1 Yes No 0 6 0 1
R:R:F90 R:R:L91 3.65 1 Yes Yes 5 5 1 2
R:R:F90 R:R:H95 5.66 1 Yes No 5 4 1 2
R:R:F90 R:R:W97 4.01 1 Yes Yes 5 9 1 2
L:L:?1 R:R:F90 8.73 1 Yes Yes 0 5 0 1
R:R:H95 R:R:L91 6.43 1 No Yes 4 5 2 2
R:R:R170 R:R:S108 13.18 1 Yes No 5 5 1 2
R:R:F111 R:R:F112 9.65 1 Yes Yes 6 5 1 1
R:R:F111 R:R:W259 7.02 1 Yes Yes 6 8 1 2
R:R:F111 R:R:Y262 9.28 1 Yes Yes 6 7 1 1
R:R:F111 R:R:F294 10.72 1 Yes No 6 6 1 2
L:L:?1 R:R:F111 10.32 1 Yes Yes 0 6 0 1
R:R:F112 R:R:M115 4.98 1 Yes Yes 5 8 1 2
R:R:F112 R:R:Y166 24.76 1 Yes Yes 5 4 1 2
R:R:F112 R:R:Y184 5.16 1 Yes Yes 5 4 1 1
R:R:F112 R:R:K210 3.72 1 Yes Yes 5 5 1 2
L:L:?1 R:R:F112 7.15 1 Yes Yes 0 5 0 1
R:R:K210 R:R:M115 5.76 1 Yes Yes 5 8 2 2
R:R:M115 R:R:W259 11.63 1 Yes Yes 8 8 2 2
R:R:H263 R:R:M115 3.94 1 Yes Yes 8 8 2 2
R:R:Y166 R:R:Y184 5.96 1 Yes Yes 4 4 2 1
R:R:K210 R:R:Y166 7.17 1 Yes Yes 5 4 2 2
R:R:R170 R:R:Y183 4.12 1 Yes Yes 5 4 1 1
R:R:R170 R:R:Y184 7.2 1 Yes Yes 5 4 1 1
L:L:?1 R:R:R170 7.13 1 Yes Yes 0 5 0 1
R:R:I173 R:R:M181 4.37 0 No Yes 3 4 2 1
R:R:D177 R:R:R175 8.34 1 Yes Yes 3 1 2 1
R:R:R175 R:R:R179 7.46 1 Yes Yes 1 1 1 2
R:R:M181 R:R:R175 16.13 1 Yes Yes 4 1 1 1
L:L:?1 R:R:R175 3.17 1 Yes Yes 0 1 0 1
R:R:D177 R:R:R179 8.34 1 Yes Yes 3 1 2 2
L:L:?1 R:R:M181 7.37 1 Yes Yes 0 4 0 1
R:R:Y183 R:R:Y184 13.9 1 Yes Yes 4 4 1 1
R:R:E269 R:R:Y183 10.1 0 No Yes 5 4 2 1
R:R:W283 R:R:Y183 7.72 1 Yes Yes 4 4 1 1
L:L:?1 R:R:Y183 13.76 1 Yes Yes 0 4 0 1
R:R:Q203 R:R:Y184 7.89 0 No Yes 3 4 2 1
L:L:?1 R:R:Y184 9.93 1 Yes Yes 0 4 0 1
R:R:E269 R:R:Q203 5.1 0 No No 5 3 2 2
R:R:K210 R:R:Y262 11.94 1 Yes Yes 5 7 2 1
R:R:H263 R:R:K210 6.55 1 Yes Yes 8 5 2 2
R:R:K210 R:R:S266 6.12 1 Yes No 5 5 2 2
R:R:H263 R:R:W259 3.17 1 Yes Yes 8 8 2 2
R:R:H263 R:R:Y262 11.98 1 Yes Yes 8 7 2 1
R:R:S266 R:R:Y262 5.09 1 No Yes 5 7 2 1
L:L:?1 R:R:Y262 7.64 1 Yes Yes 0 7 0 1
R:R:L286 R:R:W283 7.97 0 No Yes 5 4 2 1
L:L:?1 R:R:W283 7.42 1 Yes Yes 0 4 0 1
R:R:L286 R:R:P287 3.28 0 No No 5 4 2 1
L:L:?1 R:R:P287 6.42 1 Yes No 0 4 0 1
L:L:?1 R:R:T290 17.3 1 Yes No 0 6 0 1
R:R:F112 R:R:T163 2.59 1 Yes No 5 7 1 2
R:R:K105 R:R:R170 2.48 0 No Yes 7 5 2 1
R:R:M181 R:R:S18 1.53 1 Yes No 4 7 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub10.00
Average Interaction Strength8.61
Average Nodes In Shell36.00
Average Hubs In Shell21.00
Average Links In Shell59.00
Average Links Mediated by Hubs In Shell57.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub10.00
Average Interaction Strength8.61
Average Nodes In Shell36.00
Average Hubs In Shell21.00
Average Links In Shell59.00
Average Links Mediated by Hubs In Shell57.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)