CodeG6L
NamePramipexole
SynonymsPramipexole hydrochloride
Identifier(6~{S})-~{N}6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
FormulaC10 H17 N3 S
Molecular Weight211.327
SMILESCCCN[C@H]1CCc2c(sc(n2)N)C1
PubChem119570
Formal Charge0
Total Atoms31
Total Chiral Atoms1
Total Bonds32
Total Aromatic Bonds5
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CMU A Amine Dopamine D3 Homo sapiens Pramipexole - Gi1/Beta1/Gamma2 3 2021-03-10 10.1016/j.molcel.2021.01.003

A 2D representation of the interactions of G6L in 7CMU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M83 R:R:V82 4.56 0 Yes No 8 8 2 2
R:R:D110 R:R:V82 7.3 2 No No 8 8 1 2
R:R:M83 R:R:Y373 4.79 0 Yes Yes 8 8 2 1
R:R:D110 R:R:Y373 8.05 2 No Yes 8 8 1 1
L:L:?1 R:R:D110 13.77 2 Yes No 0 8 0 1
R:R:S165 R:R:V111 4.85 0 No No 8 8 2 1
R:R:L168 R:R:V111 4.47 0 Yes No 7 8 2 1
L:L:?1 R:R:V111 15.12 2 Yes No 0 8 0 1
R:R:C114 R:R:W342 6.53 0 No Yes 7 8 1 2
L:L:?1 R:R:C114 8.05 2 Yes No 0 7 0 1
R:R:S196 R:R:T115 6.4 2 No No 8 8 1 2
R:R:F188 R:R:L168 9.74 0 No Yes 7 7 2 2
R:R:F188 R:R:S192 13.21 0 No No 7 8 2 1
R:R:H349 R:R:V189 11.07 0 Yes No 8 7 1 2
L:L:?1 R:R:S192 6.35 2 Yes No 0 8 0 1
R:R:F346 R:R:S193 5.28 2 Yes No 7 8 1 2
R:R:H349 R:R:S193 4.18 0 Yes No 8 8 1 2
R:R:F346 R:R:S196 5.28 2 Yes No 7 8 1 1
L:L:?1 R:R:S196 6.35 2 Yes No 0 8 0 1
R:R:F197 R:R:F346 16.08 2 Yes Yes 9 7 2 1
R:R:F345 R:R:W342 5.01 2 Yes Yes 8 8 1 2
R:R:F346 R:R:W342 8.02 2 Yes Yes 7 8 1 2
R:R:F345 R:R:T368 5.19 2 Yes No 8 6 1 2
R:R:F345 R:R:T369 5.19 2 Yes No 8 6 1 1
L:L:?1 R:R:F345 13.39 2 Yes Yes 0 8 0 1
L:L:?1 R:R:F346 6.18 2 Yes Yes 0 7 0 1
R:R:H349 R:R:Y365 3.27 0 Yes No 8 4 1 2
L:L:?1 R:R:H349 7.61 2 Yes Yes 0 8 0 1
R:R:T369 R:R:Y373 3.75 2 No Yes 6 8 1 1
L:L:?1 R:R:T369 3.74 2 Yes No 0 6 0 1
L:L:?1 R:R:Y373 16.86 2 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.74
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.74
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)