CodeG6O
Name(4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol
Synonyms
Identifier(4~{a}~{R},10~{b}~{R})-4-propyl-3,4~{a},5,10~{b}-tetrahydro-2~{H}-chromeno[4,3-b][1,4]oxazin-9-ol
FormulaC14 H19 N O3
Molecular Weight249.306
SMILESCCCN1CCO[C@H]2[C@H]1COc3c2cc(cc3)O
PubChem5311346
Formal Charge0
Total Atoms37
Total Chiral Atoms2
Total Bonds39
Total Aromatic Bonds6
Networks1
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This ligand is also present in the following network:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CMV A Amine Dopamine D3 Homo sapiens PD128907 - Gi1/Beta1/Gamma2 2.7 2021-03-10 10.1016/j.molcel.2021.01.003

A 2D representation of the interactions of G6O in 7CMV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D110 R:R:V82 8.76 4 No No 8 8 1 2
R:R:V82 R:R:Y373 3.79 4 No Yes 8 8 2 1
R:R:M83 R:R:Y373 8.38 0 No Yes 8 8 2 1
R:R:V86 R:R:Y373 3.79 0 No Yes 8 8 2 1
R:R:D110 R:R:Y373 5.75 4 No Yes 8 8 1 1
L:L:?1 R:R:D110 18.01 4 Yes No 0 8 0 1
R:R:S165 R:R:V111 4.85 0 No No 8 8 2 1
R:R:L168 R:R:V111 4.47 0 No No 7 8 2 1
L:L:?1 R:R:V111 14.83 4 Yes No 0 8 0 1
L:L:?1 R:R:C114 11.85 4 Yes No 0 7 0 1
R:R:S196 R:R:T115 9.59 0 No No 8 8 1 2
R:R:I118 R:R:W342 11.74 0 No Yes 9 8 2 1
R:R:F188 R:R:L168 9.74 24 Yes No 7 7 2 2
R:R:F188 R:R:S192 11.89 24 Yes No 7 8 2 1
R:R:H349 R:R:V189 15.22 4 Yes No 8 7 1 2
R:R:T353 R:R:V189 14.28 4 No No 6 7 2 2
L:L:?1 R:R:S192 7.47 4 Yes No 0 8 0 1
R:R:F346 R:R:S193 5.28 4 Yes No 7 8 2 2
R:R:H349 R:R:S193 4.18 4 Yes No 8 8 1 2
L:L:?1 R:R:S196 3.74 4 Yes No 0 8 0 1
R:R:F197 R:R:F338 5.36 4 Yes Yes 9 9 2 2
R:R:F197 R:R:W342 4.01 4 Yes Yes 9 8 2 1
R:R:F197 R:R:F346 15 4 Yes Yes 9 7 2 2
R:R:F338 R:R:W342 8.02 4 Yes Yes 9 8 2 1
R:R:F346 R:R:W342 6.01 4 Yes Yes 7 8 2 1
R:R:N375 R:R:W342 14.69 0 No Yes 9 8 2 1
L:L:?1 R:R:W342 4.72 4 Yes Yes 0 8 0 1
R:R:F345 R:R:F346 8.57 0 Yes Yes 8 7 1 2
R:R:F345 R:R:T368 3.89 0 Yes No 8 6 1 2
L:L:?1 R:R:F345 21.22 4 Yes Yes 0 8 0 1
R:R:H349 R:R:T353 6.85 4 Yes No 8 6 1 2
R:R:H349 R:R:Y365 5.44 4 Yes No 8 4 1 2
L:L:?1 R:R:H349 4.27 4 Yes Yes 0 8 0 1
L:L:?1 R:R:Y373 4.86 4 Yes Yes 0 8 0 1
R:R:F345 R:R:T369 2.59 0 Yes No 8 6 1 2
L:L:?1 R:R:G372 1.42 4 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.24
Average Nodes In Shell29.00
Average Hubs In Shell9.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.24
Average Nodes In Shell29.00
Average Hubs In Shell9.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell31.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)