CodeGGL
NameGlutamic acid
SynonymsGlutamic acid
Identifier
FormulaC5 H9 N O4
Molecular Weight147.129
SMILES
PubChem44272391
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0
Networks12
 missing image

This ligand is also present in the following 12 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FIN B1 Peptide Glucagon GIP Homo Sapiens Peptide-20; GGL - Gs/Beta1/Gamma2 3.1 2022-02-23 doi.org/10.1038/s41467-022-28683-0

A 2D representation of the interactions of GGL in 7FIN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K10 R:R:L134 2.82 5 Yes No 0 5 1 2
L:L:?31 R:R:E135 16.62 5 No No 0 3 0 1
R:R:Q138 R:R:Y141 7.89 5 Yes Yes 5 7 1 2
R:R:D191 R:R:Q138 7.83 0 No Yes 7 5 2 1
L:L:K10 R:R:Q138 9.49 5 Yes Yes 0 5 1 1
L:L:?31 R:R:Q138 14.31 5 No Yes 0 5 0 1
L:L:K10 L:L:L14 4.23 5 Yes No 0 0 1 2
L:L:?31 L:L:K10 11.37 5 No Yes 0 0 0 1
R:R:E135 R:R:V139 1.43 0 No No 3 3 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength14.10
Average Nodes In Shell9.00
Average Hubs In Shell3.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BP3 B1 Peptide Calcitonin CT (AMY1) Homo Sapiens Cagrilintide - Gs/Beta1/Gamma2; RAMP1 2.2 2025-04-23 To be published

A 2D representation of the interactions of GGL in 9BP3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:I123 R:R:Y299 3.63 0 No Yes 9 7 2 1
L:L:?0 L:L:K1 5.05 0 No No 0 0 0 1
L:L:?0 L:L:?101 36.11 0 No No 0 0 0 1
L:L:?0 R:R:Y299 3.15 0 No Yes 0 7 0 1
L:L:K1 R:R:E294 10.8 0 No No 0 3 1 2
L:L:K1 R:R:H296 5.24 0 No No 0 2 1 2
L:L:T4 R:R:Y299 3.75 7 No Yes 0 7 2 1
L:L:?101 R:R:W361 7.37 0 No No 0 4 1 2
R:R:W361 R:R:Y299 3.86 0 No Yes 4 7 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength14.77
Average Nodes In Shell9.00
Average Hubs In Shell1.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BQ3 B1 Peptide Calcitonin CT (AMY2) Homo Sapiens Cagrilintide - Gs/Beta1/Gamma2; RAMP2 2.8 2025-04-23 To be published

A 2D representation of the interactions of GGL in 9BQ3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:D140 R:R:H296 6.3 0 No No 9 2 2 1
L:L:?0 L:L:K1 2.53 33 Yes No 0 0 0 1
L:L:?0 L:L:?101 40.12 33 Yes No 0 0 0 1
L:L:?0 R:R:H296 3.46 33 Yes No 0 2 0 1
L:L:?0 R:R:Y299 9.45 33 Yes No 0 7 0 1
L:L:?0 R:R:W361 3.06 33 Yes No 0 4 0 1
L:L:K1 R:R:F94 7.44 0 No No 0 3 1 2
L:L:K1 R:R:E294 8.1 0 No Yes 0 3 1 2
L:L:N3 R:R:W361 19.21 2 No No 0 4 2 1
L:L:?101 R:R:H296 12.48 33 No No 0 2 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub0.00
Average Interaction Strength11.72
Average Nodes In Shell10.00
Average Hubs In Shell2.00
Average Links In Shell10.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BUB B1 Peptide Calcitonin CT Homo Sapiens Cagrilintide - Gs/Beta1/Gamma2 2.3 2025-04-23 doi.org/10.1038/s41467-025-58680-y

A 2D representation of the interactions of GGL in 9BUB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?0 L:L:K1 3.79 0 No No 0 0 0 1
L:L:?0 L:L:?101 46.14 0 No No 0 0 0 1
L:L:?0 R:R:H296 10.37 0 No No 0 2 0 1
L:L:K1 L:L:N3 9.79 0 No No 0 0 1 2
L:L:K1 R:R:E294 12.15 0 No No 0 3 1 2
L:L:?101 R:R:Y299 28.45 0 No No 0 7 1 2
R:R:H296 R:R:L297 6.43 0 No Yes 2 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.00
Average Interaction Strength20.10
Average Nodes In Shell8.00
Average Hubs In Shell1.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell1.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BUC B1 Peptide Calcitonin CT Homo Sapiens Cagrilintide - Gs/Beta1/Gamma2 3.4 2025-04-23 To be published

A 2D representation of the interactions of GGL in 9BUC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 10.11 14 No Yes 0 0 0 1
L:L:?1 L:L:?102 36.11 14 No No 0 0 0 1
L:L:?1 R:R:H296 3.46 14 No No 0 2 0 1
L:L:K2 L:L:N4 5.6 14 Yes No 0 0 1 2
L:L:E15 L:L:K2 4.05 14 Yes Yes 0 0 2 1
L:L:K2 R:R:E294 13.5 14 Yes No 0 3 1 2
L:L:E15 R:R:E294 3.81 14 Yes No 0 3 2 2
L:L:?102 R:R:H296 12.48 14 No No 0 2 1 1
R:R:H296 R:R:Y299 2.18 14 No No 2 7 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength16.56
Average Nodes In Shell8.00
Average Hubs In Shell2.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BUD B1 Peptide Calcitonin CT Homo Sapiens Cagrilintide - Gs/Beta1/Gamma2 2.5 2025-04-23 To be published

A 2D representation of the interactions of GGL in 9BUD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 2.53 0 No No 0 0 0 1
L:L:?1 L:L:?102 30.09 0 No No 0 0 0 1
L:L:K2 L:L:N4 8.39 0 No No 0 0 1 2
L:L:K2 R:R:E294 4.05 0 No No 0 3 1 2
L:L:?102 R:R:H296 4.16 0 No No 0 2 1 2
L:L:?102 R:R:Y299 18.97 0 No No 0 7 1 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength16.31
Average Nodes In Shell7.00
Average Hubs In Shell0.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub0.67
Average Interaction Strength13.22
Average Nodes In Shell8.00
Average Hubs In Shell1.33
Average Links In Shell7.83
Average Links Mediated by Hubs In Shell3.33

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)