CodeGOQ
Name8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid
Synonyms
Identifier
FormulaC17 H11 N O7
Molecular Weight341.272
SMILES
PubChem2236
Formal Charge0
Total Atoms36
Total Chiral Atoms0
Total Bonds39
Total Aromatic Bonds16
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQL T2 Sensory Taste2 TAS2R14 Homo Sapiens Cholesterol Aristolochic acid A Gt3/Beta1/Gamma1 2.99 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of GOQ in 8XQL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:C391 A:A:L393 3.17 1 Yes No 5 7 2 1
A:A:C391 R:R:F106 4.19 1 Yes Yes 5 7 2 2
A:A:C391 R:R:Y107 5.38 1 Yes Yes 5 9 2 1
A:A:C391 R:R:I111 6.55 1 Yes Yes 5 9 2 2
A:A:L393 R:R:Y107 12.89 1 No Yes 7 9 1 1
A:A:L393 W:W:?1 7.74 1 No Yes 7 0 1 0
R:R:F106 R:R:V44 5.24 1 Yes No 7 6 2 2
R:R:V44 R:R:Y107 3.79 1 No Yes 6 9 2 1
R:R:R55 R:R:Y272 7.2 1 Yes Yes 9 5 2 2
R:R:H276 R:R:R55 11.28 1 Yes Yes 9 9 1 2
R:R:S194 R:R:T101 3.2 1 No No 8 8 1 2
R:R:L103 R:R:Y107 10.55 0 No Yes 9 9 2 1
R:R:G104 W:W:?1 6.38 0 No Yes 8 0 1 0
R:R:F106 R:R:Y107 4.13 1 Yes Yes 7 9 2 1
R:R:Y107 W:W:?1 14.57 1 Yes Yes 9 0 1 0
R:R:I111 R:R:L201 4.28 1 Yes Yes 9 9 2 1
R:R:I111 W:W:?2 4.44 1 Yes Yes 9 0 2 2
R:R:F191 R:R:F237 7.5 0 No Yes 7 6 2 1
R:R:F237 R:R:S194 5.28 1 Yes No 6 8 1 1
R:R:S194 W:W:?1 4.67 1 No Yes 8 0 1 0
R:R:F237 R:R:L195 10.96 1 Yes No 6 7 1 2
R:R:F198 R:R:I202 10.05 1 Yes No 7 8 1 2
R:R:F198 R:R:V233 7.87 1 Yes No 7 7 1 1
R:R:F198 R:R:I234 6.28 1 Yes No 7 5 1 2
R:R:F198 W:W:?1 20.44 1 Yes Yes 7 0 1 0
R:R:L201 R:R:S204 4.5 1 Yes Yes 9 9 1 2
R:R:L201 W:W:?1 9.46 1 Yes Yes 9 0 1 0
R:R:L201 W:W:?2 5.16 1 Yes Yes 9 0 1 2
R:R:S204 W:W:?2 6.53 1 Yes Yes 9 0 2 2
R:R:V233 W:W:?1 16.67 1 No Yes 7 0 1 0
R:R:F236 R:R:Y272 5.16 1 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 13.58 1 Yes Yes 9 9 2 1
R:R:F237 W:W:?1 5.3 1 Yes Yes 6 0 1 0
R:R:H276 R:R:Y272 16.33 1 Yes Yes 9 5 1 2
R:R:H276 R:R:L280 6.43 1 Yes No 9 9 1 1
R:R:H276 W:W:?1 12.79 1 Yes Yes 9 0 1 0
R:R:L280 W:W:?1 3.44 1 No Yes 9 0 1 0
R:R:G283 W:W:?1 1.06 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.32
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of GOQ in 8XQL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K385 A:A:Y358 9.55 1 Yes Yes 5 4 1 2
A:A:F394 A:A:Y358 8.25 1 Yes Yes 5 4 2 2
A:A:T380 R:R:N113 2.92 1 Yes No 6 8 2 2
A:A:T380 R:R:H208 4.11 1 Yes Yes 6 9 2 1
A:A:T380 R:R:K211 3 1 Yes No 6 5 2 2
A:A:D381 A:A:K385 9.68 1 Yes Yes 7 5 2 1
A:A:D381 R:R:H208 11.35 1 Yes Yes 7 9 2 1
A:A:D381 R:R:M212 12.48 1 Yes Yes 7 9 2 2
A:A:I384 R:R:N113 5.66 1 No No 6 8 1 2
A:A:I384 R:R:H208 6.63 1 No Yes 6 9 1 1
A:A:I384 W:W:?2 9.76 1 No Yes 6 0 1 0
A:A:F394 A:A:K385 6.2 1 Yes Yes 5 5 2 1
A:A:K385 W:W:?2 3.51 1 Yes Yes 5 0 1 0
A:A:F394 A:A:L388 7.31 1 Yes No 5 8 2 1
A:A:L388 R:R:I111 7.14 1 No Yes 8 9 1 1
A:A:L388 W:W:?2 12.04 1 No Yes 8 0 1 0
A:A:C391 R:R:I111 6.55 1 Yes Yes 5 9 2 1
R:R:I111 R:R:L201 4.28 1 Yes Yes 9 9 1 1
R:R:I111 W:W:?2 4.44 1 Yes Yes 9 0 1 0
R:R:A112 R:R:S204 3.42 0 No Yes 8 9 2 1
R:R:F114 R:R:S204 3.96 1 Yes Yes 8 9 2 1
R:R:L201 R:R:S204 4.5 1 Yes Yes 9 9 1 1
R:R:L201 W:W:?1 9.46 1 Yes Yes 9 0 1 2
R:R:L201 W:W:?2 5.16 1 Yes Yes 9 0 1 0
R:R:S204 W:W:?2 6.53 1 Yes Yes 9 0 1 0
R:R:M205 W:W:?2 19.33 0 No Yes 9 0 1 0
R:R:H208 R:R:K211 5.24 1 Yes No 9 5 1 2
R:R:H208 R:R:M212 9.19 1 Yes Yes 9 9 1 2
R:R:H208 W:W:?2 11.19 1 Yes Yes 9 0 1 0
R:R:H227 R:R:R209 10.16 0 No No 9 6 2 1
R:R:R209 W:W:?2 4.53 0 No Yes 6 0 1 0
R:R:S219 R:R:S223 3.26 0 No No 5 8 2 1
R:R:H227 R:R:S223 6.97 0 No No 9 8 2 1
R:R:S223 W:W:?2 3.73 0 No Yes 8 0 1 0
R:R:A226 W:W:?2 3.92 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.65
Average Nodes In Shell25.00
Average Hubs In Shell14.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQN T2 Sensory Taste2 TAS2R14 Homo Sapiens Cholesterol Aristolochic acid A Gi1/Beta1/Gamma1 3.05 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of GOQ in 8XQN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:L348 A:A:L353 4.15 4 Yes Yes 8 8 2 1
A:A:L348 R:R:I111 5.71 4 Yes Yes 8 9 2 2
A:A:C351 R:R:Y107 5.38 4 No Yes 4 9 2 1
A:A:C351 R:R:I111 4.91 4 No Yes 4 9 2 2
A:A:L353 R:R:Y107 4.69 4 Yes Yes 8 9 1 1
A:A:L353 W:W:?1 7.74 4 Yes Yes 8 0 1 0
R:R:V44 R:R:Y107 3.79 0 No Yes 6 9 2 1
R:R:R55 R:R:Y272 15.43 4 Yes Yes 9 5 2 2
R:R:H276 R:R:R55 13.54 4 Yes Yes 9 9 1 2
R:R:S194 R:R:T101 4.8 0 No No 8 8 1 2
R:R:L103 R:R:Y107 10.55 0 No Yes 9 9 2 1
R:R:L103 R:R:L280 4.15 0 No No 9 9 2 2
R:R:G104 W:W:?1 7.44 0 No Yes 8 0 1 0
R:R:I111 R:R:Y107 3.63 4 Yes Yes 9 9 2 1
R:R:Y107 W:W:?1 13.84 4 Yes Yes 9 0 1 0
R:R:I111 R:R:L201 7.14 4 Yes No 9 9 2 1
R:R:F191 R:R:F237 10.72 0 No No 7 6 2 1
R:R:S194 W:W:?1 7.47 0 No Yes 8 0 1 0
R:R:F237 R:R:L195 10.96 0 No No 6 7 1 2
R:R:F198 R:R:I202 8.79 4 Yes No 7 8 1 2
R:R:F198 R:R:V233 9.18 4 Yes No 7 7 1 1
R:R:F198 R:R:I234 5.02 4 Yes No 7 5 1 2
R:R:F198 W:W:?1 20.44 4 Yes Yes 7 0 1 0
R:R:L201 R:R:M205 5.65 0 No No 9 9 1 2
R:R:L201 W:W:?1 5.16 0 No Yes 9 0 1 0
R:R:S232 R:R:V233 3.23 0 No No 7 7 2 1
R:R:V233 W:W:?1 12.96 4 No Yes 7 0 1 0
R:R:F236 R:R:Y272 4.13 4 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 10.18 4 Yes Yes 9 9 2 1
R:R:F237 W:W:?1 6.06 0 No Yes 6 0 1 0
R:R:H276 R:R:Y272 11.98 4 Yes Yes 9 5 1 2
R:R:H276 R:R:L280 5.14 4 Yes No 9 9 1 2
R:R:H276 W:W:?1 13.59 4 Yes Yes 9 0 1 0
A:A:L348 R:R:A226 1.58 4 Yes No 8 8 2 2
A:A:L353 R:R:A226 1.58 4 Yes No 8 8 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.52
Average Nodes In Shell27.00
Average Hubs In Shell10.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQO T2 Sensory Taste2 TAS2R14 Homo Sapiens Cholesterol Aristolochic acid A Gi1/Beta1/Gamma1 2.77 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of GOQ in 8XQO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:C351 R:R:Y107 5.38 0 No Yes 4 9 2 1
A:A:C351 R:R:I111 4.91 0 No No 4 9 2 2
A:A:L353 R:R:Y107 5.86 2 No Yes 8 9 1 1
A:A:L353 W:W:?1 6.25 2 No Yes 8 0 1 0
R:R:V44 R:R:Y107 3.79 0 No Yes 6 9 2 1
R:R:R55 R:R:Y272 10.29 2 Yes Yes 9 5 2 2
R:R:H276 R:R:R55 12.41 2 Yes Yes 9 9 1 2
R:R:L103 R:R:Y107 11.72 0 No Yes 9 9 2 1
R:R:G104 W:W:?1 5.8 0 No Yes 8 0 1 0
R:R:Y107 W:W:?1 11.92 2 Yes Yes 9 0 1 0
R:R:I111 R:R:L201 5.71 0 No No 9 9 2 1
R:R:F191 R:R:F237 8.57 0 No Yes 7 6 2 1
R:R:F237 R:R:S194 5.28 2 Yes No 6 8 1 1
R:R:S194 W:W:?1 5.09 2 No Yes 8 0 1 0
R:R:F237 R:R:L195 13.4 2 Yes No 6 7 1 2
R:R:F198 R:R:I202 10.05 2 Yes No 7 8 1 2
R:R:F198 R:R:V233 7.87 2 Yes No 7 7 1 1
R:R:F198 R:R:I234 3.77 2 Yes No 7 5 1 2
R:R:F198 W:W:?1 15.82 2 Yes Yes 7 0 1 0
R:R:L201 W:W:?1 6.25 0 No Yes 9 0 1 0
R:R:V233 R:R:V279 3.21 2 No No 7 7 1 2
R:R:V233 W:W:?1 15.14 2 No Yes 7 0 1 0
R:R:F236 R:R:Y272 4.13 2 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 10.18 2 Yes Yes 9 9 2 1
R:R:F236 R:R:V279 5.24 2 Yes No 9 7 2 2
R:R:F237 W:W:?1 5.5 2 Yes Yes 6 0 1 0
R:R:H276 R:R:Y272 15.24 2 Yes Yes 9 5 1 2
R:R:H276 W:W:?1 12.34 2 Yes Yes 9 0 1 0
R:R:L201 R:R:S204 3 0 No Yes 9 9 1 2
R:R:G229 R:R:G283 2.11 0 No No 9 7 2 1
R:R:G283 W:W:?1 1.93 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.60
Average Nodes In Shell25.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQP T2 Sensory Taste2 TAS2R14 Homo Sapiens Cholesterol Aristolochic acid A Gt3/Beta1/Gamma1 3.29 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of GOQ in 8XQP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:C351 R:R:Y107 5.38 0 No Yes 5 9 2 1
A:A:L353 R:R:Y107 14.07 0 No Yes 7 9 2 1
R:R:V44 R:R:Y107 3.79 0 No Yes 6 9 2 1
R:R:L51 R:R:R55 17.01 0 No Yes 9 9 2 2
R:R:A100 R:R:L51 3.15 0 No No 8 9 1 2
R:R:R55 R:R:Y272 5.14 12 Yes Yes 9 5 2 1
R:R:H276 R:R:R55 12.41 12 Yes Yes 9 9 1 2
R:R:A100 W:W:?1 2.94 0 No Yes 8 0 1 0
R:R:S194 R:R:T101 6.4 0 No No 8 8 1 2
R:R:L103 R:R:Y107 3.52 0 No Yes 9 9 2 1
R:R:Y107 W:W:?1 4.37 0 Yes Yes 9 0 1 0
R:R:S194 W:W:?1 5.6 0 No Yes 8 0 1 0
R:R:F198 R:R:I202 8.79 0 No No 7 8 1 2
R:R:F198 W:W:?1 17.41 0 No Yes 7 0 1 0
R:R:F236 R:R:H276 4.53 12 Yes Yes 9 9 2 1
R:R:F236 R:R:V279 3.93 12 Yes No 9 7 2 2
R:R:F237 R:R:Y272 6.19 12 No Yes 6 5 1 1
R:R:F237 W:W:?1 15.14 12 No Yes 6 0 1 0
R:R:H276 R:R:Y272 32.67 12 Yes Yes 9 5 1 1
R:R:Y272 W:W:?1 9.47 12 Yes Yes 5 0 1 0
R:R:H276 R:R:V279 11.07 12 Yes No 9 7 1 2
R:R:H276 W:W:?1 8.79 12 Yes Yes 9 0 1 0
R:R:F191 R:R:F237 1.07 0 No No 7 6 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.10
Average Nodes In Shell19.00
Average Hubs In Shell6.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.60
Average Number Of Links With An Hub4.20
Average Interaction Strength9.04
Average Nodes In Shell24.60
Average Hubs In Shell10.60
Average Links In Shell32.40
Average Links Mediated by Hubs In Shell28.60

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)